Solid water soluble propolis composition and preparation method thereof

Abstract

The invention relates to a solid soluble propolis compound and relative preparation, wherein said invention is formed by packing anhydrous alcohol with beta- cyclodextrin (cyclodextrin or cyclodextrinderivant) to be extracted into propolis; it uses pastern bath to heat and remove wax, and uses anhydrous alcohol to extract the effective component of propolis, to be filtered, deposited, and vaporized into part alcohol dissolvent; then packing the cyclodextrin or cyclodextrin derivant, to be dried, broken and screened, to obtain the solid soluble propolis compound. The invention can effectivelykeep effect components of propolis, and the cyclodextrin can increase the solubility of effect components. The invention can be made into powder, sheet, drop, capsule and pastern, etc.

Description

Technical field

[0001] The invention belongs to the field of health food, and specifically relates to a preparation method of solid water-soluble propolis Background technique:

[0002] There are many invention patents on the preparation of water-soluble propolis. For example, the Chinese patent (CN94118328.9 Preparation Method of Water-soluble Propolis) uses glycerin soaking to obtain water-soluble propolis. Chinese patent (CN95117897.0 propolis powder and its preparation process), the powder includes purified propolis and ultrafine silica. Chinese patent (CN00137060.X A process method for purifying propolis) uses ethanol to extract, dry, and crush propolis. Chinese patent (CN03141394.3 water-soluble propolis and its preparation method), it consists of propolis, polyethylene glycol and distilled water. Chinese patent (CN200380104801.2 quaternary composition containing propolis as an active substance), using propolis active substance, hydrophilic carrier and one is amino acid, ...

Examples

Embodiment 1

[0022] 100g of wax-removing propolis raw material (hair glue), heated in a water bath to remove beeswax, dissolve it with 200ml of absolute ethanol of its weight, filter, take the supernatant, and then extract the supernatant with approximately 50ml of absolute ethanol of 1 times the volume of the propolis precipitate , Combine the supernatants, discard the residue, evaporate and recover about 100ml of ethanol solvent to obtain about 200g of purified propolis ethanol jelly, folded into a dry weight of about 60 grams.

[0023] The purified propolis is converted into a dry powder and β-cyclodextrin, and the weight ratio is 1:15 to fully mix, that is, 200g of propolis ethanol jelly (about 60 grams of propolis) and 940 grams of β-ring The solid water-soluble propolis composition of the present invention can be obtained by vigorously stirring or rolling inclusion of dextrin, hot-air drying, crushing, and sieving (mesh number of 70-100).

[0024] The solid water-soluble propolis composit...

Embodiment 2

[0026] 100g of wax-removed propolis raw material (hair glue), dissolve it with 400g of its weight in absolute ethanol, filter, take the supernatant, and then extract the supernatant with 1 time the volume of the propolis precipitate in absolute ethanol, combine the supernatants, and discard Remove the residue, evaporate and recover part of the ethanol solvent to obtain about 200g of purified propolis ethanol jelly, which is folded into a dry weight of about 60 grams.

[0027] The purified propolis is used to synthesize dry powder and hydroxypropyl β-cyclodextrin (cyclodextrin derivative), and mix it thoroughly at a weight ratio of 2:17, that is, 510 grams of hydroxypropyl β-cyclodextrin. Strong agitation or rolling clathrate, hot air drying, crushing, sieving (mesh 70-100), the solid water-soluble propolis composition of the present invention contains 11% wax-removed and purified propolis and 89% Hydroxypropyl β-cyclodextrin.

Embodiment 3

[0029] 100g of wax-removed propolis raw material (hair glue), dissolve with 300g of absolute ethanol, filter, take the supernatant, and then extract the supernatant with 1 times the volume of the propolis precipitate with absolute ethanol, combine the supernatants, and discard the residue. Evaporate and recover part of the ethanol solvent to obtain a purified ethanol jelly of about 200 g of propolis, which is folded into a dry weight of about 60 grams.

[0030] The purified propolis is converted into dry powder and α-cyclodextrin or γ-cyclodextrin, and the weight ratio is 2:15 to fully mix, that is, 450 grams of α-cyclodextrin or γ-cyclodextrin, vigorously stir or crush Pressing, hot-air drying, crushing and sieving (70-100 mesh) can obtain the solid water-soluble propolis composition of the present invention containing 12% wax-removed and purified propolis and 88% α-cyclopaste Gamma or γ-cyclodextrin.

Technical field

[0001] The invention belongs to the field of health food, and specifically relates to a preparation method of solid water-soluble propolis Background technique:

[0002] There are many invention patents on the preparation of water-soluble propolis. For example, the Chinese patent (CN94118328.9 Preparation Method of Water-soluble Propolis) uses glycerin soaking to obtain water-soluble propolis. Chinese patent (CN95117897.0 propolis powder and its preparation process), the powder includes purified propolis and ultrafine silica. Chinese patent (CN00137060.X A process method for purifying propolis) uses ethanol to extract, dry, and crush propolis. Chinese patent (CN03141394.3 water-soluble propolis and its preparation method), it consists of propolis, polyethylene glycol and distilled water. Chinese patent (CN200380104801.2 quaternary composition containing propolis as an active substance), using propolis active substance, hydrophilic carrier and one is amino acid, ...

Examples

Embodiment 1

[0022] 100g of wax-removing propolis raw material (hair glue), heated in a water bath to remove beeswax, dissolve it with 200ml of absolute ethanol of its weight, filter, take the supernatant, and then extract the supernatant with approximately 50ml of absolute ethanol of 1 times the volume of the propolis precipitate , Combine the supernatants, discard the residue, evaporate and recover about 100ml of ethanol solvent to obtain about 200g of purified propolis ethanol jelly, folded into a dry weight of about 60 grams.

[0023] The purified propolis is converted into a dry powder and β-cyclodextrin, and the weight ratio is 1:15 to fully mix, that is, 200g of propolis ethanol jelly (about 60 grams of propolis) and 940 grams of β-ring The solid water-soluble propolis composition of the present invention can be obtained by vigorously stirring or rolling inclusion of dextrin, hot-air drying, crushing, and sieving (mesh number of 70-100).

[0024] The solid water-soluble propolis composit...

Embodiment 2

[0026] 100g of wax-removed propolis raw material (hair glue), dissolve it with 400g of its weight in absolute ethanol, filter, take the supernatant, and then extract the supernatant with 1 time the volume of the propolis precipitate in absolute ethanol, combine the supernatants, and discard Remove the residue, evaporate and recover part of the ethanol solvent to obtain about 200g of purified propolis ethanol jelly, which is folded into a dry weight of about 60 grams.

[0027] The purified propolis is used to synthesize dry powder and hydroxypropyl β-cyclodextrin (cyclodextrin derivative), and mix it thoroughly at a weight ratio of 2:17, that is, 510 grams of hydroxypropyl β-cyclodextrin. Strong agitation or rolling clathrate, hot air drying, crushing, sieving (mesh 70-100), the solid water-soluble propolis composition of the present invention contains 11% wax-removed and purified propolis and 89% Hydroxypropyl β-cyclodextrin.

Embodiment 3

[0029] 100g of wax-removed propolis raw material (hair glue), dissolve with 300g of absolute ethanol, filter, take the supernatant, and then extract the supernatant with 1 times the volume of the propolis precipitate with absolute ethanol, combine the supernatants, and discard the residue. Evaporate and recover part of the ethanol solvent to obtain a purified ethanol jelly of about 200 g of propolis, which is folded into a dry weight of about 60 grams.

[0030] The purified propolis is converted into dry powder and α-cyclodextrin or γ-cyclodextrin, and the weight ratio is 2:15 to fully mix, that is, 450 grams of α-cyclodextrin or γ-cyclodextrin, vigorously stir or crush Pressing, hot-air drying, crushing and sieving (70-100 mesh) can obtain the solid water-soluble propolis composition of the present invention containing 12% wax-removed and purified propolis and 88% α-cyclopaste Gamma or γ-cyclodextrin.