Medium-and-large-sized novel closed circulating spray drying system

Abstract

The utility model relates to the technical field of drying equipment, and discloses a medium-large size novel closed circulation spray drying system which comprises a raw material medicine drying device. The raw material medicine drying device comprises a drying main tower, a vaporific raw material medicine supply assembly communicated with the drying main tower, a hot air supply assembly communicated with the drying main tower and a raw material medicine solid collecting assembly communicated with the drying main tower. The gas-liquid distribution device comprises a separation assembly communicated with the raw material medicine solid collection assembly and a liquid collection assembly communicated with the separation assembly, the separation assembly is communicated with the hot air supply assembly, and the liquid collection assembly is communicated with the vaporific raw material medicine supply assembly. The method has the effects of reducing the harm of the organic solvent for dissolving the raw material medicine to the environment and improving the cyclic utilization rate of the organic solvent.

Description

Technical Field

[0001] The present application relates to the technical field of drying equipment, and in particular to a medium-to-large-sized novel closed-cycle spray drying system. Background Art

[0002] APIs refer to the raw materials used to produce various preparations. They are the active ingredients in the preparations and are various powders, crystals, extracts, etc. prepared by chemical synthesis, plant extraction or biotechnology for use as medicines, but are substances that cannot be taken directly by patients.

[0003] When using raw materials, some of them are difficult to dissolve in water and generally require organic solvents as dilution media. Common organic solvents include acetone and dichloromethane.

[0004] At present, when drying APIs soluble in organic solvents, the drying process is generally carried out through a spray drying system. After the hot air flow dries the APIs soluble in organic solvents, organic solvents such as acetone and dichloromethane are directly discharged into the atmosphere along with the air flow, which can easily cause harm to the environment. Utility Model Content

[0005] In order to reduce the harm of organic solvents used to dissolve raw materials to the environment and improve the recycling rate of organic solvents, the present application provides a medium-to-large-scale new closed-loop spray drying system.

[0006] A medium-to-large-scale new closed-cycle spray drying system provided in this application adopts the following technical solution:

[0007] A medium-to-large-scale new closed-loop spray drying system, which is used for drying raw materials dissolved in organic solvents, comprising:

[0008] A bulk drug drying device, the bulk drug drying device comprising a drying main tower, a mist bulk drug supply assembly connected to the drying main tower, a hot air supply assembly connected to the drying main tower, and a bulk drug solid collection assembly connected to the drying main tower;

[0009] A gas-liquid splitter device, the gas-liquid splitter device comprising a separation component connected to the API solid collection component and a liquid collection component connected to the separation component, the separation component is connected to the hot air supply component, and the liquid collection component is connected to the mist API supply component;

[0010] The mist API supply component passes the mist API into the interior of the main drying tower, and the hot air supply component passes the hot air flow into the interior of the main drying tower simultaneously, the mist API is dried by the hot air flow, and the API solid collection component is used to filter and collect the API solids in the air flow, and then, the organic solvent in the air flow is condensed and separated by the separation component, the separated gas is passed into the hot air supply component again for recycling, and the liquid collection component is used to collect the organic solvent after condensation and separation, and the organic solvent in the liquid collection component is passed into the mist API supply component to dissolve the API again.

[0011] Optionally, a CIP online cleaning system is also included, and the CIP online cleaning system is connected to the liquid collection component.

[0012] Optionally, the mist API supply assembly includes a stirring tank and an atomizer located inside the main drying tower, and the stirring tank and the atomizer are connected via a feed pump.

[0013] Optionally, the hot air supply assembly includes an induced draft fan connected to the main drying tower and an explosion-proof heater for heating the airflow passing through the induced draft fan.

[0014] Optionally, the separation component is connected to a first separation component and a second separation component in the direction of gas flow, the first separation component is connected to the raw material solid collection component, and the second separation component is connected to the liquid collection component.

[0015] Optionally, the first separation component includes a primary condenser connected to the API solid collection component and a primary gas-liquid separator connected to the primary condenser, and the primary gas-liquid separator is connected to the liquid collection component.

[0016] Optionally, the liquid collection component includes a cache tank and a storage tank distributed according to the liquid flow direction, the cache tank is connected to the separation component, the cache tank is connected to the storage tank through a delivery pump, and the storage tank is connected to the mist API supply component through a metering pump.

[0017] Optionally, the API solid collection component includes a cyclone separator connected to the main drying tower and a dust removal cylinder connected to the cyclone separator, a collection cylinder is connected below the cyclone separator, and the dust removal cylinder is connected to the separation component.

[0018] In summary, the present application includes at least one of the following beneficial technical effects:

[0019] 1. When drying the API dissolved in the organic solvent, the mist API supply component sprays the atomized API into the main drying tower, and the hot air supply component blows the hot air flow into the main drying tower to dry the atomized API, and the API solid collection component collects the dried API. When the airflow passes through the separation component, the organic solvent in the airflow is separated by the separation component, and the airflow after separation of the organic solvent is again introduced into the hot air supply component for drying cycle, the liquid collection component collects the separated organic solvent, and according to the needs of the mist API supply component, it is introduced into the mist API supply component for API dissolution cycle, thereby reducing the possibility of organic solvents being discharged into the atmosphere and causing harm to the air, and at the same time, it also improves the utilization rate of organic solvents and saves the cost of organic solvents;

[0020] 2. Since the liquid collection component is also connected to the CIP online cleaning system, the collected organic solvent can also enter the CIP online cleaning system as a cleaning solvent, further improving the utilization rate of the organic solvent and saving the cost of the organic solvent;

[0021] 3. When the airflow containing APIs enters the API collection assembly, the APIs in the airflow are separated by a cyclone separator, and large particles of APIs are collected by a collection cylinder. At the same time, fine APIs are further filtered by a dust removal cylinder. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall process of an embodiment of the present application.

[0023] Description of reference numerals:

[0024] 1. induced draft fan; 2. air intake valve; 3. explosion-proof heater; 4. hot air filter; 5. atomizer; 6. feed pump; 7. stirring tank; 8. main drying tower; 9. cyclone separator; 10. dust removal cylinder; 11. dust filter; 12. primary condenser; 13. primary gas-liquid separator; 14. secondary condenser; 15. secondary gas-liquid separator; 16. buffer tank; 17. delivery pump; 18. storage tank; 19. metering pump; 20. CIP online cleaning system; 21. explosion-proof preheater; 22. oxygen analysis system; 23. impurity filter; 24. activated carbon. DETAILED DESCRIPTION

[0025] The following combination Figure 1 This application is described in further detail.

[0026] The embodiment of the present application discloses a medium-to-large-sized novel closed-cycle spray drying system.

[0027] A medium-to-large-scale new closed-loop spray drying system includes a bulk drug drying device, a gas-liquid flow separation device, and a CIP online cleaning system 20. The bulk drug drying device, the gas-liquid flow separation device, and the CIP online cleaning system 20 are interconnected.

[0028] After the API drying device dries the API, the airflow containing the organic solvent enters the gas-liquid diversion device, and the organic solvent in the airflow is separated by the gas-liquid diversion device, so that the airflow after the organic solvent is separated flows back to the API drying device to dry the API, and the separated organic solvent flows back to the API drying device to dissolve the API, thereby improving the utilization rate of the organic solvent, saving the cost of the organic solvent, and at the same time, reducing the possibility of the organic solvent being discharged into the atmosphere and affecting the environment. Since the CIP online cleaning system 20 is connected to the gas-liquid diversion device, the separated organic solvent can also enter the CIP online cleaning system 20 as a cleaning solvent, thereby improving the utilization rate of the organic solvent.

[0029] The drug drying device comprises a drying main tower 8, a mist drug supply assembly, a hot air supply assembly and a drug solid collection assembly. The mist drug supply assembly, the hot air supply assembly and the drug solid collection assembly are all connected to the drying main tower 8.

[0030] The atomized API supply assembly includes a stirring tank 7 and an atomizer 5. The stirring tank 7 is used to mix the API and the organic solvent to facilitate the API to dissolve in the organic solvent. The atomizer 5 is installed inside the drying main tower 8. The atomizer 5 is used to spray the API dissolved in the organic solvent into the drying main tower 8 in an atomized manner to increase the contact area between the API and the airflow. The stirring tank 7 and the atomizer 5 are connected through a feed pump 6.

[0031] The hot air supply assembly includes an induced draft fan 1 and an explosion-proof heater 3. The induced draft fan 1 is connected to the main drying tower 8, and the explosion-proof heater 3 is fixedly installed near the induced draft fan 1. The explosion-proof heater 3 is used to heat the airflow passing through the induced draft fan 1. The heated airflow enters the main drying tower 8 under the action of the induced draft fan 1 to dry the atomized API.

[0032] The API drying assembly includes a cyclone separator 9 and a dust removal cylinder 10. The cyclone separator 9 is connected to the main drying tower 8, and a collecting cylinder is connected below the cyclone separator 9. The dust removal cylinder 10 is connected to the cyclone separator 9. The dried API enters the cyclone separator 9 with the airflow, and the cyclone separator 9 separates the dried API in the airflow, and makes the large particles of the dried API fall into the collecting cylinder, and the large particles of the dried API are collected by the collecting cylinder. After the airflow enters the dust removal cylinder 10, the dust removal cylinder further filters and collects the API with smaller particles in the airflow, so as to further reduce the content of the dried API in the airflow.

[0033] The gas-liquid flow dividing device includes a separation component and a liquid collecting component. There are several separation components, which are distributed according to the gas flow direction. In the embodiment of the present application, there are two separation components. The two separation components are respectively a primary separation component and a secondary separation component.

[0034] The first separation assembly is close to the dust removal cylinder 10, and includes a primary condenser 12 and a primary gas-liquid separator 13. The primary condenser 12 is connected to the dust removal cylinder 10, and the primary gas-liquid separator 13 is connected to the primary condenser 12. In order to reduce the entry of impurities into the primary condenser 12, a dust filter 11 is also installed between the primary condenser 12 and the dust removal cylinder 10, so as to facilitate further interception of fine powder.

[0035] The secondary separation component includes a secondary condenser 14 and a secondary gas-liquid separator 15. The secondary condenser 14 is connected to the primary gas-liquid separator 13, the secondary gas-liquid separator 15 is connected to the secondary condenser 14, the secondary gas-liquid separator 15 is connected to the induced draft fan 1, and the primary gas-liquid separator 13 and the secondary gas-liquid separator 15 are both connected to the liquid collection component.

[0036] The gas containing the organic solvent passes through the primary condenser 12 , the primary gas-liquid separator 13 , the secondary condenser 14 and the secondary gas-liquid separator 15 in this order.

[0037] The primary condenser 12 and the secondary condenser 14 condense the organic solvent in the airflow, and allow the condensed organic solvent to flow into the liquid collecting assembly. At the same time, the airflow without organic solvent is heated again by the explosion-proof heater 3 under the action of the induced draft fan 1 and enters the interior of the drying main tower 8 to dry the atomized API. At the same time, in order to enhance the heating effect of the condensed airflow, an explosion-proof pre-heater 21 is also connected between the induced draft fan 1 and the secondary gas-liquid separator 15 to pre-heat the condensed airflow.

[0038] An air intake valve 2 is also connected between the induced draft fan 1 and the explosion-proof heater 3, and an oxygen analysis system 21 is connected between the explosion-proof preheater 21 and the induced draft fan 1. An organic solvent adsorption component is also connected between the oxygen analysis system 21 and the induced draft fan 1, and the organic solvent adsorption component includes an exhaust valve 25, an impurity filter 23 and activated carbon 24 distributed according to the gas flow direction.

[0039] When the inert gas enters the circulating spray drying system, the inlet valve 2 and the exhaust valve 25 are opened, and the inert gas enters from the exhaust valve 2, and the tail gas is discharged from the exhaust valve 25, so that the circulating spray drying system is filled with inert gas. Before the tail gas is discharged from the exhaust valve 25, the impurities in the tail gas are filtered by the impurity filter 23, and the organic solvent mixed in the air flow is adsorbed by the activated carbon 24.

[0040] The liquid collection assembly includes a buffer tank 16 and a storage tank 18. The primary gas-liquid separator 13 and the secondary gas-liquid separator 15 are both connected to the buffer tank 16, and the organic solvent condensed in the primary gas-liquid separator 13 and the secondary gas-liquid separator 15 flows into the buffer tank 16 for temporary storage.

[0041] The buffer tank 16 and the storage tank 18 are connected by a delivery pump 17, and the delivery pump 17 pumps the organic solvent in the buffer tank 16 into the storage tank 18 for storage. A metering pump 19 is installed between the storage tank 18 and the stirring tank 7, and the metering pump 19 pumps the organic solvent in the storage tank 18 into the stirring tank 7 to participate in the dissolution of the raw materials in the stirring tank 7 again, so as to facilitate the recycling of the organic solvent and reduce the possibility of the organic solvent being discharged into the atmosphere.

[0042] The CIP online cleaning system 20 is also connected to the storage tank 18 via the metering pump 19, so that the organic solvent can enter the CIP online cleaning system 20 to be used as a cleaning solvent for cleaning.

[0043] The implementation principle of a medium-to-large-scale novel closed-loop spray drying system in an embodiment of the present application is as follows: first, the circulating spray drying system is filled with inert gas through the air inlet valve 2 and the exhaust valve 25, and then, the raw material medicine is dissolved in the organic solvent of the stirring tank 7 inside the stirring tank 7, and the raw material medicine dissolved in the organic solvent is pumped into the atomizer 5 through the feed pump 6, and the atomizer 5 sprays the atomized raw material medicine solution into the drying main tower 8 in the form of atomization. At the same time, the induced draft fan 1 flows the airflow heated by the explosion-proof heater 3 into the drying main tower 8, and the hot air flow dries the atomized raw material medicine. The dried raw material medicine enters the cyclone separator 9 with the airflow, and the raw material medicine with larger particles falls into the collection tube at the bottom of the cyclone separator 9, and the raw material medicine with smaller particles enters the dust removal tube 10 with the airflow, and the small particles of raw material medicine are filtered and collected again by the dust removal tube 10, so as to further reduce the raw material medicine content in the hot airflow. Subsequently, the hot air flow enters the primary condenser 12 and the secondary condenser 14, and the condensed organic solvent and gas are separated by the primary gas-liquid separator 13 and the secondary gas-liquid separator 15. The separated gas enters the drying main tower 8 again under the action of the induced draft fan 1, and the atomized API is dried again. The condensed organic solvent flows from the primary gas-liquid separator 13 and the secondary gas-liquid separator 15 into the buffer tank 16, and the organic solvent in the buffer tank 16 is pumped into the storage tank 18 by the delivery pump 17. The metering pump 19 pumps the organic solvent in the storage tank 18 into the stirring tank 7, so that the organic solvent participates in the dissolution of the API again, and the organic solvent is recycled. At the same time, since the CIP online cleaning system 20 is also connected to the metering pump 19, it is also convenient for the metering pump 19 to pump the organic solvent in the storage tank 18 into the CIP online cleaning system 20, and use the organic solvent as a cleaning solvent.

[0044] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A medium-to-large-scale new closed-loop spray drying system, which is used to dry raw materials dissolved in organic solvents, characterized in that: include; A bulk drug drying device, the bulk drug drying device comprising a main drying tower (8), a mist bulk drug supply component connected to the main drying tower (8), a hot air supply component connected to the main drying tower (8), and a bulk drug solid collection component connected to the main drying tower (8); A gas-liquid splitter device, the gas-liquid splitter device comprising a separation component connected to the API solid collection component and a liquid collection component connected to the separation component, the separation component is connected to the hot air supply component, and the liquid collection component is connected to the mist API supply component; The mist API supply component passes the mist API into the interior of the drying main tower (8), and the hot air supply component simultaneously passes the hot air flow into the interior of the drying main tower (8), the mist API is dried by the hot air flow, and the API solid collection component is used to filter and collect the API solids in the air flow, and then the organic solvent in the air flow is condensed and separated by the separation component, the separated gas is passed into the hot air supply component again for recycling, and the liquid collection component is used to collect the organic solvent after condensation and separation, and the organic solvent in the liquid collection component is passed into the mist API supply component to dissolve the API again.

2. A medium-to-large-sized novel closed-cycle spray drying system according to claim 1, characterized in that: It also includes a CIP online cleaning system (20), and the CIP online cleaning system (20) is connected to the liquid collection component.

3. A medium-to-large-sized novel closed-cycle spray drying system according to claim 1, characterized in that: The mist API supply assembly comprises a stirring tank (7) and an atomizer (5) located inside the main drying tower (8), and the stirring tank (7) and the atomizer (5) are connected via a feed pump (6).

4. A medium-to-large-sized novel closed-cycle spray drying system according to claim 1, characterized in that: The hot air supply assembly comprises an induced draft fan (1) connected to the main drying tower (8) and an explosion-proof heater (3) for heating the airflow passing through the induced draft fan (1).

5. A medium-to-large-sized novel closed-cycle spray drying system according to claim 1, characterized in that: The separation component is connected with a first separation component and a second separation component in the direction of gas flow. The first separation component is connected with the raw material solid collection component, and the second separation component is connected with the liquid collection component.

6. A medium-to-large-sized novel closed-cycle spray drying system according to claim 5, characterized in that: The first separation component comprises a primary condenser (12) connected to the API solid collection component and a primary gas-liquid separator (13) connected to the primary condenser (12), and the primary gas-liquid separator (13) is connected to the liquid collection component.

7. A medium-to-large-sized novel closed-cycle spray drying system according to claim 1, characterized in that: The liquid collection component includes a buffer tank (16) and a storage tank (18) distributed according to the liquid flow direction, the buffer tank (16) is connected to the separation component, the buffer tank (16) is connected to the storage tank (18) through a delivery pump (17), and the storage tank (18) is connected to the mist API supply component through a metering pump (19).

8. A medium-to-large-sized novel closed-cycle spray drying system according to claim 1, characterized in that: The raw material drug solid collection component comprises a cyclone separator (9) connected to the main drying tower (8) and a dust removal cylinder (10) connected to the cyclone separator (9); a collection cylinder is connected below the cyclone separator (9); and the dust removal cylinder (10) is connected to the separation component.

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