Heating type reaction kettle for synthesizing medical intermediates

Abstract

The utility model discloses a heating type reaction kettle for synthesis of medical intermediates, which relates to the field of medicine production and aims to solve the problems that the reaction efficiency of the existing medicine production is low and the cost is higher when a kettle body in the prior art is used, the technical scheme is as follows: the heating type reaction kettle comprises a kettle body, and a bracket is fixed outside the kettle body through screws; a rotating shaft is rotationally connected inside the kettle body, a motor fixed on the kettle body through a screw is arranged at the end, far away from the kettle body, of the rotating shaft, a discharging pipe is fixed at the end, far away from the motor, of the kettle body, an electromagnetic valve is fixed outside the discharging pipe, a feeding pipe communicated with the kettle body is arranged on one side of the motor, and a telescopic stirring assembly is fixed outside the rotating shaft. The telescopic stirring assembly comprises a movably arranged top feeler lever, a plurality of convex blocks are fixed on the inner wall of the kettle body, and the top feeler lever intermittently abuts against the convex blocks after rotating, so that the technical effects of reducing the external structure, reducing the production cost and improving the reaction efficiency are achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of drug production, in particular to a heating reaction kettle for synthesizing pharmaceutical intermediates. Background Art

[0002] With the development of modern medicine, there are more and more types of medicines. In the production process of general medicines, chemical raw materials or chemical products are required to facilitate the synthesis of medicines, and Western medicines are usually obtained by organic synthesis. These organic synthesis processes are often carried out in reactors, but traditional reactors are generally in a fixed state, with a long reaction time, which is time-consuming and labor-intensive. For example, a pharmaceutical reactor specially used for pharmaceuticals is disclosed in Chinese patent CN206315797U. The device opens the feed valves in the two feed chambers above the reaction ball, and then puts the pharmaceutical intermediates to be reacted into the two feed chambers above the reaction ball. The pharmaceutical intermediates fall onto the partition of the reaction ball, and the rotating motor starts to work. The rotating motor drives the two rotating shafts to rotate on the two support rings, and the two rotating shafts drive the reaction ball to rotate evenly. The rotation of the reaction ball drives the pharmaceutical intermediate to flow in and out of the through hole of the partition plate and turn evenly, so that the components of the pharmaceutical intermediate can fully contact each other and react completely. After the pharmaceutical intermediate reacts fully, the rotating motor stops working, and the two blocking mechanisms start working, driving the fixed block to move through the hydraulic cylinder, and the fixed block drives the blocking block to extend to block the shielding rod, so that the reaction ball can stop quickly. At this time, the discharge valve on the discharge pipe below the reaction ball is in an open state. After the reaction is completed, the pharmaceutical intermediate flows into the collection box through the discharge pipe for collection. Although the device can speed up the reaction time, when the reaction ball stops rotating, it cannot always ensure that the blocking block just blocks the shielding rod, and the volume of the reactor is large, the accessories required for the rotation of the entire reaction ball are high, and the required cost is also high. Utility Model Content

[0003] The utility model aims to provide a heating reaction kettle for synthesizing pharmaceutical intermediates which has low use cost, simple structure and high reaction efficiency.

[0004] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0005] A heating reactor for synthesizing pharmaceutical intermediates comprises a reactor body, which is spherical, a bracket is fixed with screws on the outside of the reactor body, a rotating shaft is rotatably connected inside the reactor body, a motor fixed to the reactor body with screws is provided at the end of the rotating shaft away from the reactor body, a discharge pipe is fixed at the end of the reactor body away from the motor, a solenoid valve is fixed on the outside of the discharge pipe, a feed pipe connected to the reactor body is provided on one side of the motor, a telescopic stirring assembly is fixed on the outside of the rotating shaft, the telescopic stirring assembly comprises a movably arranged top contact rod, a raised block is fixed on the inner wall of the reactor body, a plurality of raised blocks are provided, and the top contact rod intermittently contacts the raised blocks after rotation.

[0006] Furthermore, the telescopic stirring assembly also includes fixed tubes fixed on both sides of the rotating shaft, and the fixed tubes are provided with a plurality of fixed tubes along the axial direction of the rotating shaft. The fixed tubes are spirally slidably connected to the top contact rod inside, and a plurality of stirring rods are provided on the side of the top contact rod, and the top contact rod is in an arc shape away from the end of the fixed tube.

[0007] By adopting the above technical solution, the contact end of the top contact rod and the raised block is in arc contact, which effectively reduces rotational friction and reduces energy consumption.

[0008] Furthermore, a threaded through groove is provided on the side surface of the fixed tube, and a guide block is fixed to the end of the top contact rod facing the fixed tube, and the guide block slides along the inside of the threaded through groove.

[0009] By adopting the above technical solution, when the top-touch rod is resisted, the guide block can slide along the inside of the threaded groove, thereby realizing the rotation of the top-touch rod, thereby causing the stirring rod to rotate, stirring the medicine inside the kettle body in two planes, fully improving the stirring efficiency, and then improving the reaction efficiency, and this can be achieved without rotating the kettle body, thereby reducing the external structure and reducing production costs.

[0010] Furthermore, the top-touch rod is rotatably connected to a spring base toward the fixed tube end, and a spring is fixed between the spring base and the fixed tube.

[0011] By adopting the above technical solution, after the top contact rod is impacted by the raised block, the spring can be compressed, and then when the top contact rod does not contact the raised block, the spring can be reset to drive the top contact rod to continue rotating, thereby keeping the top contact rod rotating along the rotating axis.

[0012] Furthermore, the protruding blocks are fixed on the inner wall of the kettle body, and the protruding blocks are equidistantly arranged along the upper and lower and circumferential directions of the kettle body. At the upper and lower positions, each layer of protruding blocks corresponds to one of the top contact rods.

[0013] Furthermore, the length of the top contact rod gradually increases toward the center of the kettle body.

[0014] By adopting the above technical solution, since the distance between the protruding block and the top contact rod near the center of the kettle body increases, providing a top contact rod with a corresponding length can ensure that the top contact rod can rotate itself during the rotation process.

[0015] Furthermore, a heating plate is fixed outside the kettle body, and the heating plate screws are installed on the side of the kettle body. There are several heating plates, and each heating plate is placed between two layers of raised blocks at upper and lower positions.

[0016] By adopting the above technical solution, the heating plate is located between the protruding blocks, and the drug liquid inside the kettle body is squeezed by the protruding blocks and flows to the position between the protruding blocks. Therefore, the drug liquid between the protruding blocks is continuously replaced and contacts the heating plate, which can improve the reaction efficiency.

[0017] In summary, the beneficial technical effects of the utility model are:

[0018] 1. The motor drives the rotating shaft to rotate and the top contact rod and the fixed tube structure with a threaded through groove are adopted. After the motor is turned on, the top contact rod can rotate in both the vertical plane and the horizontal plane, thereby achieving the effect of improving the reaction efficiency without rotating the kettle body, thereby reducing the external structure and reducing the production cost;

[0019] 2. A top-touch rod is used and a spring base is connected when the top-touch rod rotates toward the fixed pipe end. After the top-touch rod is hit by the raised block, the spring can be compressed. When the top-touch rod does not contact the raised block, the spring can be reset to drive the top-touch rod to continue rotating. The top-touch rod can be kept rotating along the rotating shaft to achieve long-term multi-directional stirring.

[0020] 3. A heating plate is used, and the drug liquid inside the kettle body is squeezed by the protruding blocks and flows to the position between the protruding blocks. Therefore, the drug liquid between the protruding blocks is constantly replaced and contacts the heating plate, which can improve the reaction efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification, but do not constitute a limitation of the present invention. In the accompanying drawings:

[0022] Figure 1 This is a schematic structural diagram of a heating reactor for synthesizing pharmaceutical intermediates in this embodiment;

[0023] Figure 2 This is a schematic diagram of the internal structure of a heating reactor for synthesizing pharmaceutical intermediates in this embodiment;

[0024] Figure 3 This is a heating reactor for synthesizing a pharmaceutical intermediate in this embodiment. Figure 2 Schematic diagram of the top view;

[0025] Figure 4 This is a heating reactor for synthesizing a pharmaceutical intermediate in this embodiment. Figure 3 Schematic diagram of the cross-sectional structure along the AA line;

[0026] Figure 5 This is a heating reactor for synthesizing a pharmaceutical intermediate in this embodiment. Figure 4 Enlarged schematic diagram at point A in the middle.

[0027] In the figure, 1, kettle body; 2, bracket; 3, rotating shaft; 4, motor; 5, discharge pipe; 6, solenoid valve; 7, feed pipe; 8, top contact rod; 9, raised block; 10, fixed tube; 11, stirring rod; 12, threaded groove; 13, guide block; 14, spring base; 15, spring; 16, heating plate. DETAILED DESCRIPTION

[0028] The utility model is further described in detail below in conjunction with the accompanying drawings.

[0029] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0030] See also Figure 1-5 The utility model provides a technical solution: a heating reactor for synthesizing pharmaceutical intermediates, comprising a reactor body 1, the reactor body 1 is spherical, a bracket 2 is screwed to the outside of the reactor body 1, a rotating shaft 3 is rotatably connected to the inside of the reactor body 1, a motor 4 fixed to the reactor body 1 by screws is provided at the end of the rotating shaft 3 away from the reactor body 1, a discharge pipe 5 is fixed to the end of the reactor body 1 away from the motor 4, a solenoid valve 6 is fixed to the outside of the discharge pipe 5, a feed pipe 7 connected to the reactor body 1 is provided on one side of the motor 4, a telescopic stirring assembly is fixed to the outside of the rotating shaft 3, the telescopic stirring assembly comprises a movably arranged top contact rod 8, a raised block 9 is fixed to the inner wall of the reactor body 1, and a plurality of raised blocks 9 are provided, and the top contact rod 8 intermittently contacts the raised block 9 after rotating.

[0031] In this embodiment, the drug reactants inside the kettle body 1 are stirred by a telescopic stirring assembly, and the intermittent contact between the top contact rod 8 and the protruding block 9 is utilized to achieve stirring on the vertical plane and the horizontal plane, thereby achieving sufficient stirring.

[0032] Specifically, the telescopic stirring assembly includes a top touch rod 8 and a fixed tube 10 fixed on both sides of the rotating shaft 3. The fixed tube 10 is provided with a plurality of top touch rods 8 along the axial direction of the rotating shaft 3. The fixed tube 10 is spirally slidably connected to the top touch rod 8 inside. A plurality of stirring rods 11 are provided on the side of the top touch rod 8. The top touch rod 8 is in an arc shape away from the end of the fixed tube 10.

[0033] A threaded through groove 12 is provided on the side of the fixing tube 10 , and a guide block 13 is fixed to the end of the top contact rod 8 facing the fixing tube 10 , and the guide block 13 slides along the inside of the threaded through groove 12 .

[0034] The top contact rod 8 is rotated toward the end of the fixed tube 10 and is connected to the spring 15 base 14 , and a spring 15 is fixed between the spring 15 base 14 and the fixed tube 10 .

[0035] Then, when the top-touch rod 8 contacts the raised block 9, the top-touch rod 8 moves toward the inside of the fixed tube 10, so that under the guiding action of the guide block 13, the guide block 13 moves along the inside of the threaded through groove 12, and the top-touch rod 8 starts to rotate while moving toward the inside of the fixed tube 10, thereby driving the stirring rod 11 to rotate, thereby achieving stirring on the horizontal plane. At the same time, under the drive of the motor 4, the motor 4 drives the rotating shaft 3 to rotate, and the driving shaft can drive the fixed tube 10 and the top-touch rod 8 to rotate in the vertical plane.

[0036] The raised blocks 9 are fixed on the inner wall of the kettle body 1 , and the raised blocks 9 are equidistantly arranged along the upper and lower and circumferential directions of the kettle body 1 . At the upper and lower positions, each layer of the raised blocks 9 corresponds to one of the top contact rods 8 .

[0037] The top contact rod 8 provided at the same time gradually extends in length toward the center of the kettle body 1 .

[0038] Furthermore, the raised block 9 is intermittently arranged, so when the rotating shaft 3 drives the fixed tube 10 to rotate, the top contact rod 8 contacts the raised block 9 and moves toward the inside of the fixed tube 10 while rotating, and the spring 15 is in a compressed state at this time. After rotating past the raised block 9, the spring 15 is reset, driving the top contact rod 8 to move away from the end of the fixed tube 10, and the top contact rod 8 keeps rotating at this time.

[0039] At the same time, since the protruding block 9 located near the center of the kettle body 1 is far away from the top-touch rod 8, the length of the top-touch rod 8 located near the center of the kettle body 1 is longer.

[0040] A heating plate 16 is further fixed to the outside of the kettle body 1 , and the heating plate 16 is screwed to the side of the kettle body 1 . There are a plurality of heating plates 16 , and each heating plate 16 is placed between two layers of raised blocks 9 at upper and lower positions.

[0041] The heating plate 16 is a conventional resistance heating plate 16 in the prior art. The heating plate 16 is located between the protrusions 9. The drug liquid inside the kettle body 1 is squeezed by the protrusions 9 and flows to the position between the protrusions 9. Therefore, the drug liquid between the protrusions 9 is continuously replaced and contacts the heating plate 16, which can improve the reaction efficiency.

[0042] Working principle: Add the reaction drug into the kettle body 1 through the feed pipe 7, close the feed pipe 7 after adding, turn on the motor 4, and the motor 4 drives the rotating shaft 3 to rotate. During the rotation of the rotating shaft 3, the top contact rod 8 and the protruding block 9 are intermittently in contact, thereby driving the top contact rod 8 and the stirring rod 11 to rotate, thereby realizing stirring in the horizontal and vertical planes and improving the stirring efficiency. At the same time, the heating plate 16 is used to heat the drug solution at the position of the two layers of protruding blocks 9, thereby increasing the heating efficiency while improving the stirring efficiency, thereby effectively improving the reaction efficiency. After the reaction is completed, the solenoid valve 6 is opened, and the reaction product flows out along the discharge pipe 5.

[0043] In particular, the sealing structure of the feed pipe can adopt existing technologies such as valves and cover plates.

[0044] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0045] Finally, it should be noted that the above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Although the utility model is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions recorded in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A heating reactor for synthesis of pharmaceutical intermediates, characterized in that: The heating reactor for synthesizing pharmaceutical intermediates comprises a reactor body (1), wherein the reactor body (1) is spherical, a bracket (2) is fixed to the outside of the reactor body (1) by screws, a rotating shaft (3) is rotatably connected to the inside of the reactor body (1), a motor (4) fixed to the reactor body (1) by screws is provided at the end of the rotating shaft (3) away from the reactor body (1), a discharge pipe (5) is fixed to the end of the reactor body (1) away from the motor (4), a solenoid valve (6) is fixed to the outside of the discharge pipe (5), a feed pipe (7) connected to the reactor body (1) is provided on one side of the motor (4), a telescopic stirring assembly is fixed to the outside of the rotating shaft (3), the telescopic stirring assembly comprises a movably arranged top contact rod (8), a protruding block (9) is fixed to the inner wall of the reactor body (1), a plurality of the protruding blocks (9) are provided, and the top contact rod (8) intermittently contacts the protruding block (9) after rotating.

2. A heating reactor for synthesis of pharmaceutical intermediates according to claim 1, characterized in that: The telescopic stirring assembly also includes a fixed tube (10) fixed on both sides of the rotating shaft (3), the fixed tube (10) is provided with a plurality of rods along the axial direction of the rotating shaft (3), the fixed tube (10) is spirally slidably connected to the top contact rod (8) inside, a plurality of stirring rods (11) are provided on the side of the top contact rod (8), and the end of the top contact rod (8) away from the fixed tube (10) is in an arc shape.

3. A heating reactor for synthesis of pharmaceutical intermediates according to claim 2, characterized in that: A threaded through groove (12) is provided on the side of the fixing tube (10), and a guide block (13) is fixed to the end of the top contact rod (8) facing the fixing tube (10), and the guide block (13) slides inside the threaded through groove (12).

4. A heating reactor for synthesizing pharmaceutical intermediates according to claim 2, characterized in that: The top contact rod (8) is rotatably connected to the end of the fixed tube (10) and is provided with a spring (15) base (14); a spring (15) is fixed between the spring (15) base (14) and the fixed tube (10).

5. A heating reactor for synthesis of pharmaceutical intermediates according to claim 1, characterized in that: The protruding blocks (9) are fixed on the inner wall of the kettle body (1), and the protruding blocks (9) are arranged equidistantly along the upper and lower and circumferential directions of the kettle body (1). At the upper and lower positions, each layer of protruding blocks (9) corresponds to one of the top contact rods (8).

6. A heating reactor for synthesis of pharmaceutical intermediates according to claim 1, characterized in that: The length of the top contact rod (8) gradually increases towards the center of the kettle body (1).

7. A heating reactor for synthesis of pharmaceutical intermediates according to claim 5, characterized in that: A heating plate (16) is also fixed to the outside of the kettle body (1), and the heating plate (16) is screwed onto the side of the kettle body (1). A plurality of heating plates (16) are provided, and each heating plate (16) is placed between two layers of raised blocks (9) at upper and lower positions.

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