Laboratory mouse tail suspension device

Abstract

The utility model provides a laboratory mouse tail suspension device. The laboratory mouse tail suspension device comprises a body, a top cover and a suspension structure, wherein an accommodating chamber is formed in the body and is used for placing a laboratory mouse; the top cover is arranged at the top of the body, and a plurality of through holes are formed in the top cover and used for ventilation of laboratory mice; one end of the hanging structure is fixedly connected below the top cover, and the other end of the hanging structure is used for hanging the tail part of a laboratory mouse. The experimental mouse tail suspension device not only can be used for experimental mouse weightlessness model experiments, but also is small in occupied area, changes of the experimental mouse in the modeling process can be observed at any time, and meanwhile the survival rate of the experimental mouse is high. In addition, the device is simple in structure and easy to operate.

Description

Technical Field

[0001] The utility model relates to a tail suspension device for experimental mice. Background Art

[0002] During the space flight, astronauts will be affected by various factors, such as weightlessness and overweight, which will cause a series of pathological or physiological changes in the human body, which is not conducive to the health of astronauts. At present, the model of tail-suspended mice or rats is an internationally recognized ground-based simulated weightlessness model. By simulating the weightless environment and gravity loading, observing the changes in physiological and biochemical indicators, and studying the mechanism of gravity's influence on organisms, including the adaptability and tolerance of gravity to organisms, it has important scientific significance and application value for studying gravity biology, space physiology, clinical medicine and other fields. Therefore, it is necessary to provide an experimental device for suspending the tail of experimental mice.

[0003] CN211583623U discloses an experimental device for suspending the tail of an experimental mouse, which includes a mouse cage and a suspension device, wherein the suspension device includes a suspension device support body and a suspension structure with adjustable height, wherein the suspension device support body is fixed on the mouse cage and provides support for the suspension structure, wherein the suspension structure is placed directly above the mouse cage through the suspension device support body, and a suspension rope suspended into the mouse cage is arranged on the suspension structure. Although the experimental device for suspending the tail of an experimental mouse provided in the document can adjust the suspension height of the experimental mouse after the mouse tail is fixed at the beginning of the experiment, its suspension structure includes a longitudinal adjustment column and a transverse suspension frame, wherein the longitudinal adjustment column and the transverse suspension frame are vertically connected, and the adjustment column and the suspension frame are respectively connected to the suspension device support body, and the adjustment structure is relatively complicated.

[0004] CN219230235U discloses a rat tail suspension restraint device, including a fixture, a cage, a bracket, a suspension rope and a muscle patch for fixing the rat; the bracket is formed by vertically fixing a vertical rod and a horizontal rod, and is installed above the top cage net of the cage, one end of the suspension rope is fixed on the bracket, and the other end is connected to the fixture. When in use, the fixture is connected to the muscle patch to suspend the rat tail to reduce the damage caused to the rat tail. The device requires a specific bracket to suspend the rat. Although it can reduce the damage to the rat tail to a certain extent, multiple muscle patches are required to restrain the rat during the experiment. On the whole, the structure of the device is relatively complicated. Utility Model Content

[0005] In view of this, the purpose of the utility model is to provide a laboratory mouse tail suspension device, which can not only be used for laboratory mouse weightlessness model experiments, but also occupies a small area, can observe the changes of the laboratory mouse modeling process at any time, and has a high survival rate of the laboratory mouse. The utility model adopts the following technical solutions to achieve the above technical objectives.

[0006] The utility model provides a laboratory mouse tail suspension device, comprising: a body, a top cover and a suspension structure; wherein:

[0007] The body is formed with a receiving chamber for placing the experimental mouse;

[0008] The top cover is arranged on the top of the body, and is provided with a plurality of through holes for ventilation of the experimental mice;

[0009] One end of the hanging structure is fixedly connected to the bottom of the top cover, and the other end is used to hang the tail of the experimental mouse.

[0010] According to the experimental mouse tail suspension device of the utility model, preferably, the main body is configured as a cylindrical structure with an opening on the top, and it is a transparent structure; the top cover is configured as a circular structure, which matches the top opening of the main body.

[0011] According to the experimental mouse tail suspension device of the utility model, preferably, a scale area is provided along the circumference of the body.

[0012] According to the experimental mouse tail suspension device of the utility model, preferably, a plurality of angle marks are arranged at intervals along the circumference of the body.

[0013] According to the laboratory mouse tail suspension device of the utility model, preferably, the suspension structure includes a suspension part, a connecting part and a fixing part; the suspension part is configured as a hook-shaped structure, which is fixedly connected to the bottom of the top cover; one end of the connecting part is connected to the suspension part, and the other end fixes the laboratory mouse through the fixing part.

[0014] According to the experimental mouse tail suspension device of the utility model, preferably, the connecting part includes a first connecting part, a second connecting part and a movable locking piece; the first connecting part is configured as a closed annular structure, and the second connecting part is a linear structure, and the two are connected by a movable locking piece.

[0015] According to the experimental mouse tail suspension device of the utility model, preferably, the circumference of the first connecting portion and the length of the second connecting portion change in inverse proportion with the movement of the movable locking member.

[0016] According to the experimental mouse tail suspension device of the present invention, preferably, the first connecting portion and the second connecting portion are an integrally formed structure and scales are provided on both the first connecting portion and the second connecting portion.

[0017] According to the experimental mouse tail suspension device of the utility model, preferably, it also includes a reserved hole; the reserved hole is arranged below the side of the body and is used to provide drinking water to the experimental mouse.

[0018] According to the experimental mouse tail suspension device of the utility model, preferably, it also includes a drinking device; the drinking device is fixed on the main body and close to the reserved hole.

[0019] The experimental mouse tail suspension device of the utility model can not only be used for experimental mouse weightlessness model experiments, but also occupies a small area, and can observe the changes of experimental mouse modeling at any time. At the same time, the survival rate of experimental mice is high, and the rate of ulceration and necrosis of the experimental mouse tail is low. The device has a simple structure and is easy to operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The utility model is a schematic diagram of the structure of the experimental mouse tail suspension device.

[0021] Figure 2 This is a schematic diagram of the structure of the experimental mouse tail suspension device of Example 1 after the experimental mouse is suspended.

[0022] Figure 3 It is a structural schematic diagram of the connecting part of the utility model.

[0023] Figure 4 This is a schematic diagram of the structure of the experimental mouse tail suspension device of Example 3 after the experimental mouse is suspended.

[0024] Description of reference numerals:

[0025] 1-Ontology;

[0026] 2-top cover, 21-through hole;

[0027] 3-suspension structure, 31-suspension part; 32-connection part, 321-first connection part, 322-second connection part, 323-movable locking member;

[0028] 4- Reserved holes;

[0029] 5- Drinking water device;

[0030] Among them, I represents the scale area; II represents the angle mark. DETAILED DESCRIPTION

[0031] The present invention is described in more detail below, but the present invention is not limited thereto.

[0032] The utility model discloses a laboratory mouse tail suspension device, which comprises a main body, a top cover, a suspension structure, a reserved hole and a drinking water device, and is described in detail below.

[0033] Ontology

[0034] The utility model has a housing chamber formed in the body for placing experimental mice and conducting weightlessness model experiments.

[0035] In the utility model, the shape of the main body is preferably set to a cylindrical structure with an open top. The cylindrical structure has no sharp angles, which can prevent the experimental mice from being stuck or injured by the corners of the main body during the experiment.

[0036] In the present invention, the body is set as a transparent structure, so that the changes in the experimental mouse modeling process can be observed at any time. It is preferably made of acrylic material. This can reduce costs compared to stainless steel.

[0037] In the utility model, the height of the body can be 20 to 35 cm, preferably 25 to 30 cm, and more preferably 25 to 28 cm. The caliber of the body can be 13 to 22 cm, preferably 15 to 20 cm, and more preferably 16 to 18 cm. A body of such size occupies a small area, and can realize a laboratory mouse in a single body. At the same time, it can be freely combined according to the actual experimental space, saving the experimental space.

[0038] In some embodiments, a scale area may be provided along the circumference of the body. The size of the body may be set according to actual needs. The sizes of the experimental mice are basically the same. Corresponding tests may be performed according to the height of the body and the size of the experimental mice. The angle between the body of the experimental mouse and the ground is controlled within a suitable angle. There will be a height range corresponding to the height of the base of the tail of the experimental mouse, i.e., the scale area. When used later, if the height of the base of the tail of the experimental mouse falls within this scale area, it means that the angle between the body of the experimental mouse and the ground is appropriate, which is easy to judge and further reduces errors.

[0039] In other embodiments, a plurality of angle marks are arranged at intervals along the circumference of the body. The length of the angle mark can be 3 to 5 cm, preferably 4 to 5 cm. The interval between adjacent angle marks can be 3 to 5 cm, preferably 4 to 5 cm. This makes it easy to determine the angle between the body of the experimental mouse and the ground from various angles.

[0040] Top cover

[0041] The top cover of the utility model is arranged on the top of the body and matches with the top opening of the body.

[0042] In the utility model, the top cover can be a circular structure. A plurality of through holes are provided on the top cover for ventilation of the experimental mice. The number of through holes can be adjusted according to the reagent requirements.

[0043] In the present invention, the top cover is configured as a transparent structure, and the material may be acrylic.

[0044] Suspension structure

[0045] One end of the suspension structure of the utility model is fixedly connected to the bottom of the top cover, and the other end is used to suspend the tail of the experimental mouse. The suspension structure is mainly used to suspend the tail of the experimental mouse, which can not only perform a weightlessness model experiment on the experimental mouse but also ensure the survival rate of the experimental mouse.

[0046] In the utility model, the hanging structure includes a hanging part, a connecting part and a fixing part. The hanging part is set as a hook-shaped structure, which is fixed under the top cover; one end of the connecting part is connected to the hanging part, and the other end fixes the experimental mouse through the fixing part.

[0047] In the utility model, the connection part includes a first connection part, a second connection part and a movable locking part. The first connection part is set as a closed annular structure, and the second connection part is a linear structure. The two are connected by a movable locking part, thus forming a structure similar to a "q" shape. The first connection part and the second connection part are an integrally formed structure, and the circumference of the first connection part and the length of the second connection part change in inverse proportion with the movement of the movable locking part. When the movable locking part moves upward, that is, the circumference of the first connection part becomes shorter and the length of the second connection part becomes longer, the experimental mouse will move downward; when the movable locking part moves downward, that is, the circumference of the first connection part becomes longer and the length of the second connection part becomes shorter, the experimental mouse will move upward. In this way, the distance between the experimental mouse and the bottom of the body and the angle between the body of the experimental mouse and the ground can be adjusted.

[0048] In the present invention, scales can also be set on both the first connection part and the second connection part. There is a correlation between the height of the hanging part from the bottom of the body, the positions of the first connection part, the second connection part and the fixed part, and the correlation can be calculated and fitted, and the angle between the body of the experimental mouse and the ground can be adjusted more accurately in combination with the scales on the first connection part and the second connection part.

[0049] In the present invention, the angle between the body of the experimental mouse and the ground can be 25° to 45°, preferably 28° to 40°, and more preferably 30° to 35°.

[0050] In the utility model, the hanging part is provided as a hook made of stainless steel metal material, so that the strength can be ensured.

[0051] Reserved hole

[0052] The reserved hole of the utility model is arranged below the side of the main body and is used for providing drinking water to the experimental mice.

[0053] In the present invention, there are no special requirements for the shape of the reserved hole, as long as it has a certain height and width. The reserved hole can be set to be circular, square or polygonal; preferably square, such as rectangular. The height of the reserved hole can be 2 to 5 cm, preferably 3 to 4 cm; the width can be 0.5 to 0.8 cm, preferably 0.55 to 0.65 cm. According to a specific embodiment of the present invention, the height of the reserved hole is 3 cm and the width is 0.6 cm. The distance between the bottom of the reserved hole and the bottom of the body can be 3 to 6 cm, preferably 3.5 to 4.5 cm. This makes it convenient for experimental mice to drink water.

[0054] Drinking water device

[0055] The drinking water device of the utility model is fixed on the main body and arranged close to the reserved hole, and is used for feeding experimental mice with drinking water.

[0056] In the utility model, the drinking water device comprises a bottle body and a bottle mouth. The bottle body is fixed on the main body and close to the reserved hole. The bottle mouth extends into the reserved hole, and the drinking water is fed to the experimental mice through the reserved hole.

[0057] Example 1

[0058] Figure 1 The utility model is a schematic diagram of the structure of the experimental mouse tail suspension device. Figure 2 The utility model is a schematic structural diagram of the experimental mouse tail suspension device after the experimental mouse is suspended. Figure 3 It is a structural schematic diagram of the connecting part of the utility model.

[0059] like Figures 1 to 3 As shown, the experimental mouse tail suspension device of this embodiment includes a main body 1, a top cover 2, a suspension structure 3, a reserved hole 4 and a drinking water device 5.

[0060] like Figure 1 and Figure 2 As shown, a housing chamber is formed in the body 1 for placing the experimental mouse. The body 1 is configured as a cylindrical structure with an open top, and the material is acrylic. The cylindrical structure has no sharp angles to prevent the experimental mouse from being stuck or injured by the corners of the body 1 during the experiment. The acrylic material is a transparent material, so that the changes in the experimental mouse modeling process can be observed at any time. In this embodiment, a scale area I is provided on the circumference of the body 1, and the height of the body 1 is 25 cm and the diameter is 16 cm.

[0061] The top cover 2 is arranged on the top of the body 1, and is provided with a plurality of through holes 21 for ventilation of the experimental mice. The material of the top cover 2 is also acrylic.

[0062] like Figure 2 and Figure 3As shown, the hanging structure 3 includes a hanging part 31, a connecting part 32 and a fixing part (not shown). The hanging part 31 is fixedly connected to the bottom of the top cover 2 and is used to hang the experimental mouse; one end of the connecting part 32 is connected to the hanging part 31, and the other end fixes the experimental mouse through the fixing part, thereby hanging the experimental mouse. The connecting part 32 is fixed to the tail of the experimental mouse by the fixing part, and the position of the fixing part fixing the tail of the experimental mouse can be changed frequently, which can prevent the tail of the experimental mouse from festering or necrosis. The connecting part 32 includes a first connecting part 321, a second connecting part 322 and a movable locking member 323. The first connecting part 321 is set as a closed annular structure, and the second connecting part 322 is a linear structure. The two are an integral structure and are connected by the movable locking member 323, thus forming a structure similar to a "q" shape. The circumference of the first connecting part 321 and the length of the second connecting part 322 change in inverse proportion with the movement of the movable locking member 323. When the movable locking member 323 moves upward, that is, the circumference of the first connection part 321 becomes shorter, the length of the second connection part 322 becomes longer, and the experimental mouse will move downward; when the movable locking member 323 moves downward, that is, the circumference of the first connection part 321 becomes longer, the length of the second connection part 322 becomes shorter, and the experimental mouse will move upward. In this way, the distance between the experimental mouse and the bottom of the body 1 and the angle between the experimental mouse body and the bottom of the body 1 can be adjusted. In this embodiment, the hanging part 31 is set as a hook made of stainless steel metal; the experimental mouse keeps its two front limbs on the ground and the hind limbs suspended in the air, and the angle between the experimental mouse body and the ground is 30°. The fixing part can be a medical tape.

[0063] The reserved hole 4 is arranged at the lower side of the body 1 for providing drinking water to the experimental mice. The reserved hole 4 is arranged in a rectangular shape, with a height of 3 cm and a width of 0.6 cm.

[0064] The drinking water device 5 comprises a bottle body and a bottle mouth. The bottle body is fixed on the main body 1 and close to the reserved hole 4, and the bottle mouth extends into the reserved hole 4, and the drinking water is fed to the experimental mice through the reserved hole 4.

[0065] The following describes the working process:

[0066] like Figure 2As shown, the tail of the experimental mouse is fixed to one end of the connecting part 32 by the fixing part, and then the other end of the connecting part 32 is connected to the hanging part 31 set on the top cover 2. Then the top cover 2 is covered on the main body 1, and the experimental mouse also enters the main body 1 due to the tail suspension. The distance between the experimental mouse and the bottom and the angle between the experimental mouse body and the ground can be adjusted by adjusting the length of the connecting part 32. The experimental mouse keeps the two forelimbs on the ground, the hind limbs hanging in the air, and the angle between the body and the ground is 30°. The bottle body of the drinking water device 5 is fixed on the outside of the main body 1 and close to the reserved hole 4, and the bottle mouth is inserted into the reserved hole 4. The reserved hole 4 is rectangular, and the height of the drinking water device 5 can be moved up and down to meet the drinking needs of the experimental mouse. Then a subsequent weightlessness simulation experiment of the experimental mouse is carried out. An appropriate group of experimental mice was selected for the experiment, and the survival rate of the experimental mice reached 95.5%, and the ulceration and necrosis rate of the tail of the experimental mice was 0%.

[0067] Example 2

[0068] The difference from the first embodiment is that no scale area I is provided in the circumferential direction of the main body 1 , and scales are provided on both the first connecting portion 321 and the second connecting portion 322 .

[0069] Example 3

[0070] like Figure 4 As shown, the difference between this embodiment and embodiment 1 is that: no scale area I is provided on the circumference of the body 1, and a plurality of angle marks II are provided at intervals along the circumference of the body 1. The length of the angle mark II is 5 cm; the interval between adjacent angle marks II is 5 cm; this makes it easy to judge the angle between the body of the experimental mouse and the ground from various angles.

[0071] The present invention is not limited to the above-mentioned embodiments. Without departing from the essential content of the present invention, any deformation, improvement, and substitution that can be thought of by those skilled in the art shall fall within the scope of the present invention.

Claims

1. A tail suspension device for experimental mice, characterized in that: include: body, top cover and suspension structure; wherein, The body is formed with a receiving chamber for placing the experimental mouse; The top cover is arranged on the top of the body, and is provided with a plurality of through holes for ventilation of the experimental mice; The hanging structure includes a hanging part, a connecting part and a fixing part; the hanging part is set as a hook-shaped structure, which is fixed under the top cover; one end of the connecting part is connected to the hanging part, and the other end fixes the experimental mouse through the fixing part.

2. The tail suspension device for experimental mice according to claim 1, characterized in that: The main body is configured as a cylindrical structure with an opening at the top, and the structure is transparent; the top cover is configured as a circular structure, which matches the top opening of the main body.

3. The tail suspension device for experimental mice according to claim 2, characterized in that: A scale area is arranged along the circumference of the body.

4. The tail suspension device for experimental mice according to claim 2, characterized in that: A plurality of angle marks are arranged at intervals along the circumference of the body.

5. The tail suspension device for experimental mice according to claim 1, characterized in that: The connecting part includes a first connecting part, a second connecting part and a movable locking member; the first connecting part is configured as a closed annular structure, and the second connecting part is a linear structure, and the two are connected by a movable locking member.

6. The tail suspension device for experimental mice according to claim 5, characterized in that: The circumference of the first connection portion and the length of the second connection portion change in inverse proportion to the movement of the movable locking member.

7. The tail suspension device for experimental mice according to claim 6, characterized in that: The first connection portion and the second connection portion are an integrally formed structure and scales are provided on both the first connection portion and the second connection portion.

8. The tail suspension device for experimental mice according to claim 1, characterized in that: It also includes a reserved hole; the reserved hole is arranged below the side of the main body and is used to provide drinking water to the experimental mice.

9. The tail suspension device for experimental mice according to claim 8, characterized in that: It also includes a drinking water device; the drinking water device is fixed on the main body and close to the reserved hole.

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