Production device of 5-aminolevulinic acid hydrochloride crystal

Abstract

The utility model discloses a production device of 5-aminolevulinic acid hydrochloride crystals, and relates to the technical field of crystallization, an outlet of a 5-aminolevulinic acid hydrochloride purified liquid tank is communicated with a first crystallizing tank, an inlet of the first crystallizing tank is respectively communicated with a seed crystal tank and a first ethanol tank, and an outlet of a concentration crystallizing tank is communicated with a finished product tank; a temperature sensor is arranged in the first crystallizing tank, a jacket of the first crystallizing tank is communicated with a cold water inlet pipeline and a cold water outlet pipeline, a first regulating valve is arranged on the cold water inlet pipeline, and the temperature sensor and the first regulating valve are interlocked to a control system. Through gradient cooling, the possibility of crystal explosion is greatly reduced, the obtained 5-aminolevulinic acid hydrochloride is more uniform in crystal form, and the crystallization yield and quality of the product are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of crystallization, in particular to a production device for 5-aminolevulinic acid hydrochloride crystals. Background Art

[0002] 5-aminolevulinic acid hydrochloride is often used as a supplement for culturing Escherichia coli cells for the biosynthesis of heme. 5-aminolevulinic acid hydrochloride has a high solubility in water, with a solubility of more than 150g / 100g water at 20°C. The yield of direct cooling crystallization is low, and crystal explosion is prone to occur during the crystallization process, resulting in small and uneven 5-aminolevulinic acid hydrochloride crystals with many impurities, which greatly affects the quality of the product. Summary of the invention

[0003] The technical problem to be solved by the utility model is: in view of the deficiencies in the prior art, a production device for 5-aminolevulinic acid hydrochloride crystals is provided, and the prepared 5-aminolevulinic acid hydrochloride crystals have good uniformity and high product quality.

[0004] In order to solve the above technical problems, the technical solution of the utility model is:

[0005] A production device for 5-aminolevulinic acid hydrochloride crystals, comprising a 5-aminolevulinic acid hydrochloride purification liquid tank, wherein the outlet of the 5-aminolevulinic acid hydrochloride purification liquid tank is connected to a first crystallization tank via a pipeline, the inlet of the first crystallization tank is connected to a seed tank and a first ethanol tank via pipelines, respectively, and the outlet of the first crystallization tank is connected to a finished product tank via a pipeline;

[0006] A temperature sensor is arranged in the first crystallization tank, the jacket of the first crystallization tank is connected with a cold water inlet pipe and a cold water outlet pipe, a first regulating valve is arranged on the cold water inlet pipe, and the temperature sensor and the first regulating valve are interlocked to a control system.

[0007] As an improved technical solution, the outlet of the first ethanol tank is provided with a second regulating valve and a flow sensor, and the second regulating valve, the temperature sensor and the flow sensor are interlocked to a control system.

[0008] As an improved technical solution, the outlet of the 5-aminolevulinic acid hydrochloride purification liquid tank is connected to a second crystallization tank through a pipeline, the inlet of the second crystallization tank is connected to a second ethanol tank through a pipeline, the outlet of the second crystallization tank is connected to an intermediate tank through a pipeline, the inlet of the intermediate tank is connected to a concentrated hydrochloric acid tank through a pipeline, and the outlet of the intermediate tank is connected to the first crystallization tank through a pipeline.

[0009] As an improved technical solution, the outlet of the intermediate tank is connected to a temporary storage tank through a pipeline, and the outlet of the temporary storage tank is connected to the first crystallization tank through a pipeline.

[0010] As a preferred technical solution, the outlet of the first crystallization tank is connected to a filter through a pipeline, and the outlet of the filter is connected to the finished product tank through a pipeline.

[0011] As a preferred technical solution, the outlet of the filter is connected to a dryer through a pipeline, and the outlet of the dryer is connected to the finished product tank through a pipeline.

[0012] Due to the adoption of the above technical solution, the beneficial effects of the utility model are:

[0013] The utility model discloses a production device for 5-aminolevulinic acid hydrochloride crystals, comprising a 5-aminolevulinic acid hydrochloride purification liquid tank, wherein the outlet of the 5-aminolevulinic acid hydrochloride purification liquid tank is connected with a first crystallization tank through a pipeline, the inlet of the first crystallization tank is respectively connected with a seed tank and a first ethanol tank through pipelines, and the outlet of the first crystallization tank is connected with a finished product tank through a pipeline; a temperature sensor is arranged in the first crystallization tank, a jacket of the first crystallization tank is connected with a cold water inlet pipeline and a cold water outlet pipeline, a first regulating valve is arranged on the cold water inlet pipeline, and the temperature sensor and the first regulating valve are interlocked to a control system. After the purified 5-aminolevulinic acid hydrochloride solution is put into the first crystallization tank, it is first vacuum concentrated, then seed crystals are added, and part of ethanol is added, and the temperature of the material in the first crystallization tank is cooled at a certain rate, and 5-aminolevulinic acid hydrochloride gradually begins to crystallize. The control system adjusts the opening of the first regulating valve according to the value of the temperature sensor, so that the cooling rate of the material in the first crystallization tank is maintained within a certain range. Through gradient cooling, the possibility of crystal explosion is greatly reduced, the obtained 5-aminolevulinic acid hydrochloride crystal form is more uniform, and the crystallization yield and quality of the product are improved.

[0014] The outlet of the first ethanol tank of the utility model is provided with a second regulating valve, the temperature sensor and the flow sensor, and the second regulating valve and the flow sensor are interlocked to a control system. The control system adjusts the opening and closing of the second regulating valve according to the value of the temperature sensor, adds the remaining ethanol in sections, and cooperates with gradient cooling, thereby further reducing the possibility of crystal explosion and improving the quality of the product.

[0015] The outlet of the 5-aminolevulinic acid hydrochloride purification liquid tank is connected to the second crystallizer through a pipeline, the inlet of the second crystallizer is connected to the second ethanol tank through a pipeline, the outlet of the second crystallizer is connected to the intermediate tank through a pipeline, the inlet of the intermediate tank is connected to the concentrated hydrochloric acid tank through a pipeline, and the outlet of the intermediate tank is connected to the first crystallizer through a pipeline. First, ethanol is added to the second crystallizer, and the product is precipitated by cooling and crystallizing to obtain a crude 5-aminolevulinic acid hydrochloride, and then the crude 5-aminolevulinic acid hydrochloride enters the intermediate tank, is dissolved by concentrated hydrochloric acid under heating conditions, and then enters the first crystallizer again for secondary crystallization under the action of ethanol, thereby greatly improving the purity of the product.

[0016] The outlet of the intermediate tank is connected to a temporary storage tank through a pipeline, and the outlet of the temporary storage tank is connected to the first crystallization tank through a pipeline. The 5-aminolevulinic acid hydrochloride crude product in the intermediate tank is temporarily stored and kept warm by the temporary storage tank, and is stirred more evenly, so that the crystallization effect is better after entering the first crystallization tank.

[0017] The outlet of the first crystallization tank is connected to a filter through a pipeline, the outlet of the filter is connected to the finished product tank through a pipeline, the outlet of the filter is connected to a dryer through a pipeline, and the outlet of the dryer is connected to the finished product tank through a pipeline. The solid and liquid are separated by the filter, which is convenient for subsequent material drying, saves energy and production costs, and further reduces the moisture content of the material, thereby improving the quality of the product.

[0018] The outlet of the first crystallization tank is provided with a material transfer pump, and the outlet of the material transfer pump is connected to the filter and the first crystallization tank through pipelines. The material in the first crystallization tank is externally circulated by the material transfer pump, so that the crystallization effect is better and the crystallization cycle is shortened.

[0019] The outlet of the filter is connected to the inlet of the material transfer pump through a pipeline, and the filtrate is pumped back into the first crystallization tank for recycling, thereby improving the crystallization yield. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The utility model is further described below in conjunction with the accompanying drawings and embodiments.

[0021] Figure 1 It is a structural schematic diagram of an embodiment of the utility model;

[0022] Wherein: 1. 5-aminolevulinic acid hydrochloride purification liquid tank; 2. first crystallization tank; 3. seed tank; 4. first ethanol tank; 5. finished product tank; 6. temperature sensor; 7. cold water inlet pipe; 8. cold water outlet pipe; 9. first regulating valve; 10. second regulating valve; 11. flow sensor; 12. second crystallization tank; 13. second ethanol tank; 14. intermediate tank; 15. concentrated hydrochloric acid tank; 16. temporary storage tank; 17. filter; 18. dryer; 19. transfer pump. DETAILED DESCRIPTION

[0023] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0024] like Figure 1 As shown, a production device for 5-aminolevulinic acid hydrochloride crystals comprises a 5-aminolevulinic acid hydrochloride purified liquid tank 1, the outlet of the 5-aminolevulinic acid hydrochloride purified liquid tank 1 is connected to a first crystallization tank 2 through a pipeline, the inlet of the first crystallization tank 2 is connected to a seed tank 3 and a first ethanol tank 4 through pipelines, respectively, and the outlet of the first crystallization tank 2 is connected to a finished product tank 5 through a pipeline; a temperature sensor 6 is provided in the first crystallization tank 2, a jacket of the first crystallization tank 2 is connected to a cold water inlet pipeline 7 and a cold water outlet pipeline 8, a first regulating valve 9 is provided on the cold water inlet pipeline 7, and the temperature sensor 6 and the first regulating valve 9 are interlocked to a control system. After the purified 5-aminolevulinic acid hydrochloride solution is put into the first crystallizer 2, it is first vacuum concentrated, then seed crystals are added, and part of ethanol is added, and the temperature of the material in the first crystallizer 2 is cooled at a certain rate, and 5-aminolevulinic acid hydrochloride gradually begins to crystallize. The control system adjusts the opening of the first regulating valve 9 according to the value of the temperature sensor 6, so that the cooling rate of the material in the first crystallizer 2 is maintained within a certain range. Through gradient cooling, the possibility of crystal explosion is greatly reduced, the obtained 5-aminolevulinic acid hydrochloride crystal form is more uniform, and the crystallization yield and quality of the product are improved.

[0025] The outlet of the first ethanol tank 4 is provided with a second regulating valve 10 and a flow sensor 11. The second regulating valve 10, the temperature sensor 6 and the flow sensor 11 are interlocked with a control system. The control system adjusts the opening and closing of the second regulating valve 10 according to the value of the temperature sensor 6, and adds the remaining ethanol in stages, and cooperates with gradient cooling, which further reduces the possibility of crystal explosion and improves the quality of the product.

[0026] The outlet of the 5-aminolevulinic acid hydrochloride purification liquid tank 1 is connected to the second crystallizer 12 through a pipeline, the inlet of the second crystallizer 12 is connected to the second ethanol tank 13 through a pipeline, the outlet of the second crystallizer 12 is connected to the intermediate tank 14 through a pipeline, the inlet of the intermediate tank 14 is connected to the concentrated hydrochloric acid tank 15 through a pipeline, and the outlet of the intermediate tank 14 is connected to the first crystallizer 2 through a pipeline. First, ethanol is added to the second crystallizer 12, and the product is precipitated by cooling and crystallization to obtain a crude 5-aminolevulinic acid hydrochloride, and then the crude 5-aminolevulinic acid hydrochloride enters the intermediate tank 14, is dissolved by concentrated hydrochloric acid under heating conditions, and then enters the first crystallizer 2 again for secondary crystallization under the action of ethanol, which greatly improves the purity of the product.

[0027] The outlet of the intermediate tank 14 is connected to a temporary storage tank 16 through a pipeline, and the outlet of the temporary storage tank 16 is connected to the first crystallization tank 2 through a pipeline. The temporary storage tank 16 temporarily stores and keeps warm the crude 5-aminolevulinic acid hydrochloride in the intermediate tank 14, and stirs it more evenly, so that the crystallization effect is better after entering the first crystallization tank 2.

[0028] The outlet of the first crystallization tank 2 is connected to a filter 17 through a pipeline, the outlet of the filter 17 is connected to the finished product tank 5 through a pipeline, the outlet of the filter 17 is connected to a dryer 18 through a pipeline, and the outlet of the dryer 18 is connected to the finished product tank 5 through a pipeline. The solid and liquid are separated by the filter 17, which is convenient for subsequent material drying, saves energy and production costs, and further reduces the moisture content of the material, thereby improving the quality of the product.

[0029] The outlet of the first crystallization tank 2 is provided with a material transfer pump 19, and the outlet of the material transfer pump 19 is respectively connected to the filter 17 and the first crystallization tank 2 through a pipeline. The material in the first crystallization tank 2 is externally circulated by the material transfer pump 19, the crystallization effect is better, and the crystallization cycle is shortened.

[0030] The outlet of the filter 17 is connected to the inlet of the transfer pump 19 through a pipeline, and the filtrate is pumped back into the first crystallization tank 2 for recycling, thereby improving the crystallization yield.

[0031] It should be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the claims attached to this application.

Claims

1. A production device for 5-aminolevulinic acid hydrochloride crystals, comprising a 5-aminolevulinic acid hydrochloride purification liquid tank, characterized in that: The outlet of the 5-aminolevulinic acid hydrochloride purified liquid tank is connected to the first crystallization tank through a pipeline, the inlet of the first crystallization tank is connected to the seed tank and the first ethanol tank through pipelines, and the outlet of the first crystallization tank is connected to the finished product tank through a pipeline; A temperature sensor is arranged in the first crystallization tank, the jacket of the first crystallization tank is connected with a cold water inlet pipe and a cold water outlet pipe, a first regulating valve is arranged on the cold water inlet pipe, and the temperature sensor and the first regulating valve are interlocked to a control system.

2. A production device for 5-aminolevulinic acid hydrochloride crystals as claimed in claim 1, characterized in that: The outlet of the first ethanol tank is provided with a second regulating valve and a flow sensor, and the second regulating valve, the temperature sensor and the flow sensor are interlocked to a control system.

3. A production device for 5-aminolevulinic acid hydrochloride crystals according to claim 1, characterized in that: The outlet of the 5-aminolevulinic acid hydrochloride purification liquid tank is connected to the second crystallization tank through a pipeline, the inlet of the second crystallization tank is connected to the second ethanol tank through a pipeline, the outlet of the second crystallization tank is connected to the intermediate tank through a pipeline, the inlet of the intermediate tank is connected to the concentrated hydrochloric acid tank through a pipeline, and the outlet of the intermediate tank is connected to the first crystallization tank through a pipeline.

4. A production device for 5-aminolevulinic acid hydrochloride crystals as claimed in claim 3, characterized in that: The outlet of the intermediate tank is connected to a temporary storage tank through a pipeline, and the outlet of the temporary storage tank is connected to the first crystallization tank through a pipeline.

5. The production device of 5-aminolevulinic acid hydrochloride crystals according to claim 1, characterized in that: The outlet of the first crystallization tank is connected to a filter through a pipeline, and the outlet of the filter is connected to the finished product tank through a pipeline.

6. A production device for 5-aminolevulinic acid hydrochloride crystals as claimed in claim 5, characterized in that: The outlet of the filter is connected to a dryer through a pipeline, and the outlet of the dryer is connected to the finished product tank through a pipeline.

7. The production device of 5-aminolevulinic acid hydrochloride crystals according to claim 5, characterized in that: A material transfer pump is provided at the outlet of the first crystallization tank, and the outlet of the material transfer pump is connected to the filter and the first crystallization tank through pipelines respectively.

8. The production device of 5-aminolevulinic acid hydrochloride crystals according to claim 7, characterized in that: The outlet of the filter is connected to the inlet of the material transfer pump through a pipeline.

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