Exosome extractor flexible to operate

Abstract

The exosome extractor flexible to operate comprises a base, a working plate and an extracting assembly, the upper side surface of the base is sunken downwards to form a containing groove, and two guide rods are symmetrically installed on the edge of the front side of the upper side surface of the base. According to the exosome extraction device, the working plate is arranged, so that a user can easily adjust the position of the working plate up and down, the height of the extraction assembly is accurately adjusted, different experiment requirements are met, and great convenience and higher precision are provided for exosome extraction; according to the exosome extraction device, an extracted reagent bottle can be effectively fixed, so that the operation stability and accuracy are improved, a reliable guarantee is provided for the extraction process, the superiority and convenience of the exosome extraction device in practical application are fully embodied, and a better effect is brought to exosome extraction.

Description

Technical Field

[0001] The utility model belongs to the field of extraction equipment, and in particular relates to an exosome extractor with flexible operation. Background Art

[0002] Mesenchymal stem cell exosome extractor is a device specially used to extract exosomes secreted by mesenchymal stem cells. However, the current exosome extractor has the problem of inflexible operation in actual use. If the operation is inflexible, the operation steps of the exosome extractor are cumbersome, and a lot of time and energy are required to adjust and set up, which seriously affects the work efficiency. This is because there is a lack of flexible operation parts. The lack of flexible operation parts will not only lead to the above problems, but also the extractor is difficult to adapt quickly when processing positions at different heights, and frequent manual adjustments are required, which not only increases the workload of the operator, but also may lead to the generation of operational errors. Therefore, it is necessary to propose a new structure to solve the above technical problems. Utility Model Content

[0003] In view of the deficiencies in the prior art, the purpose of the present invention is to provide an exosome extractor with flexible operation to solve the problems raised in the above-mentioned background technology.

[0004] The utility model is realized through the following technical scheme: an exosome extractor with flexible operation, comprising: a base, a working plate and an extraction component, the upper surface of the base is recessed downward to form a receiving groove, two guide rods are symmetrically installed on the front edge of the upper surface of the base, two screw slides are symmetrically installed on the rear surface of the base, a working plate is installed above the base through the guide rods and the screw slides, a test tube rack and a control console are installed on the upper surface of the working plate, four extraction components are installed on the upper surface of the working plate, the extraction component comprises: a centrifugal pump, an extraction tube 1, an extraction tube 2, a gripping component and an extraction head, an extraction tube 1 is installed on the upper surface of the centrifugal pump, an extraction tube 2 is installed on the lower surface of the centrifugal pump passing through the working plate, and an extraction head and a gripping component are installed on the end of the extraction tube 2 away from the working plate.

[0005] As a preferred embodiment, a universal wheel with a self-locking structure is installed at each of the four corners of the lower surface of the base, a baffle is installed at the center position of the accommodating groove of the base, and the two guide rods pass through the left edge of the upper surface of the working plate.

[0006] As a preferred embodiment, the rear surface of the working plate is slidably connected to the screw slide rail, the length and width of the working plate are the same as the length and width of the base, a test tube rack is installed at the center position of the rear edge of the upper surface of the working plate, and a control console is installed at the center position of the front edge of the upper surface of the working plate. When in use, the working plate is slidably connected to the screw slide rail on the rear surface of the base, ensuring that the working plate can move up and down smoothly during use. At the same time, the two guide rods passing through the left edge of the upper surface of the working plate further ensure the stability and accuracy of the movement of the working plate, so that the user can easily adjust the position of the working plate up and down, thereby accurately adjusting the height of the extraction component to adapt to different experimental needs, providing great convenience and higher precision for exosome extraction.

[0007] As a preferred embodiment, two centrifugal pumps are symmetrically installed on the left edge and the right edge of the upper surface of the working plate, and an extraction pipe 1 is installed at the outlet of the centrifugal pump. The extraction pipe 1 is a U-shaped structure with an opening downward, and an extraction pipe 2 is installed at the outlet of the centrifugal pump through the working plate.

[0008] As a preferred embodiment, the gripping assembly includes: a hinge and a gripper, an extraction head is provided at one end of the extraction tube 2 away from the working plate, three hinges are evenly installed on the outer surface of the end of the extraction tube 2 away from the working plate, and three grippers are hingedly connected to the outer surface of the extraction tube 2 through three hinge damping. When in use, when mesenchymal stem cells are extracted, the extracted reagent bottle can be effectively fixed, which not only improves the stability and accuracy of the operation, but also provides reliable protection for the extraction process, fully reflects its superiority and convenience in practical applications, and brings better results for exosome extraction.

[0009] As a preferred embodiment, the three grippers are in a J-shaped structure, and the central axis of the second extraction tube is located inside the receiving groove.

[0010] After adopting the above technical scheme, the beneficial effects of the utility model are as follows: by setting a working plate, four extraction components are installed on the upper surface of the working plate, the rear surface of the working plate is slidably connected to the screw slide rail on the rear surface of the base, and two guide rods are penetrated through the left edge of the upper surface of the working plate. When in use, the working plate is slidably connected to the screw slide rail on the rear surface of the base, ensuring that the working plate can move up and down smoothly during use. At the same time, the two guide rods penetrating the left edge of the upper surface of the working plate further ensure the stability and accuracy of the movement of the working plate, so that the user can easily adjust the position of the working plate up and down, thereby accurately adjusting the height of the extraction component to adapt to different experimental needs, providing great convenience and higher precision for exosome extraction.

[0011] By setting a gripping assembly, the gripping assembly includes: a hinge and a claw, and three hinges are evenly installed on the outer surface of the end of the extraction tube 2 away from the working plate. The outer surface of the extraction tube 2 is hinged with three claws through three hinge damping. When in use, when mesenchymal stem cells are extracted, the extracted reagent bottle can be effectively fixed, which not only improves the stability and accuracy of the operation, but also provides reliable protection for the extraction process, fully reflects its superiority and convenience in practical applications, and brings better results for exosome extraction. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0013] Figure 1 This is a schematic diagram of the overall structure of an exosome extractor with flexible operation according to the utility model.

[0014] Figure 2 This is a schematic diagram of a gripping component of a flexible exosome extractor of the utility model.

[0015] In the figure, 100 is a base, 110 is a universal wheel, 120 is a baffle, 130 is a guide rod, and 140 is a screw guide rail;

[0016] 200 - working plate, 210 - test tube rack, 220 - centrifugal pump, 221 - extraction tube 1, 222 - extraction tube 2, 223 - extraction head, 224 - hinge, 225 - gripper, 230 - control console. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0018] See also Figure 1 to Figure 2The utility model provides a technical solution: an exosome extractor with flexible operation, comprising: a base 100, a working plate 200 and an extraction component, the upper surface of the base 100 is concave downward to form a receiving groove, two guide rods 130 are symmetrically installed on the front edge of the upper surface of the base 100, and two screw rod slide rails 140 are symmetrically installed on the rear surface of the base 100, and the working plate 200 is installed above the base 100 through the guide rods 130 and the screw rod slide rails 140, and the upper side of the working plate 200 A test tube rack 210 and a control console 230 are installed on the surface, and four extraction components are installed on the upper surface of the working plate 200, which include: a centrifugal pump 220, an extraction tube 1 221, an extraction tube 222, a gripping component and an extraction head 223. The extraction tube 1 221 is installed on the upper surface of the centrifugal pump 220, and the extraction tube 222 is installed on the lower surface of the centrifugal pump 220, which passes through the working plate 200, and the extraction head 223 and the gripping component are installed on the end of the extraction tube 222 away from the working plate 200.

[0019] See also Figure 1 , Figure 2 As the first embodiment of the utility model: a universal wheel 110 with a self-locking structure is installed at each of the four corners of the lower surface of the base 100, a baffle 120 is installed at the center of the receiving groove of the base 100, and two guide rods 130 pass through the left edge of the upper surface of the working plate 200;

[0020] The rear surface of the working plate 200 is slidably connected to the screw guide rail 140. The length and width of the working plate 200 are the same as those of the base 100. A test tube rack 210 is installed at the center of the rear edge of the upper surface of the working plate 200. A control console 230 is installed at the center of the front edge of the upper surface of the working plate 200. The test tube rack 210 on the upper surface of the working plate 200 can neatly and orderly place the test tubes required for extraction, which is convenient for operation while ensuring the safety and stability of the test tubes and improving work efficiency. The universal wheel 110 allows the extraction device to be easily moved between different positions, which increases the mobility and flexibility of the device, makes the operation more convenient, and adapts to the needs of various experimental environments.

[0021] Two centrifugal pumps 220 are symmetrically installed on the left edge and the right edge of the upper surface of the working plate 200, and an extraction pipe 1 221 is installed at the outlet of the centrifugal pump 220. The extraction pipe 1 221 is in a downward-opening U-shaped structure. The outlet of the centrifugal pump 220 penetrates the working plate 200 and is installed with an extraction pipe 222;

[0022] During use, when it is necessary to extract mesenchymal stem cells, the user first prepares a reagent bottle filled with mesenchymal stem cells, and then places the reagent bottle inside the receiving tank so that the bottle mouth of the reagent bottle is aligned with the extraction head 223. Then, the user can control the lead screw slide through the console 230 to rotate the lead screw of the lead screw slide 140 through the motor, thereby driving the working plate 200 slidably connected to the lead screw slide 140 to move up and down until the extraction head 223 under the working plate 200 is inserted into the reagent bottle. It should be noted that the diameter of the bottle mouth of the reagent bottle must be larger than the diameter of the extraction head 223. After the extraction head 223 is inserted into the interior of the reagent bottle, the user starts the centrifugal pump 220 to make the centrifugal pump 220 work (the centrifugal pump 220 is a prior art, and its working steps and working principles for extracting the mesenchymal stem cells inside the reagent bottle are not repeated here). The centrifugal pump 220 extracts the mesenchymal stem cells inside the reagent bottle. The stem cells are extracted into the extraction tube 222, and then the mesenchymal stem cells are extracted into the extraction tube 1 221 through the centrifugal pump 220. Then a reagent tube is set at the end of the extraction tube 1 221 away from the centrifugal pump 220. Then, the centrifugal pump 220 will extract the mesenchymal stem cells into the reagent tube. The four extraction components can extract four mesenchymal stem cells at the same time, which speeds up the extraction efficiency. The working plate 200 is slidably connected to the screw guide rail 140 on the rear surface of the base 100, which ensures that the working plate 200 can move up and down smoothly during use. At the same time, the two guide rods 130 passing through the left edge of the upper surface of the working plate 200 further ensure the stability and accuracy of the movement of the working plate 200, so that the user can easily adjust the position of the working plate 200 up and down, thereby accurately adjusting the height of the extraction component to meet different experimental needs, providing great convenience and higher precision for exosome extraction.

[0023] See also Figure 1 , Figure 2 As the second embodiment of the utility model: the gripping assembly includes: a hinge 224 and a gripper 225, an extraction head 223 is provided at one end of the extraction tube 222 away from the working plate 200, three hinges 224 are evenly installed on the outer surface of the end of the extraction tube 222 away from the working plate 200, and three grippers 225 are hingedly connected to the outer surface of the extraction tube 222 through three hinges 224;

[0024] The three grippers 225 are in a J-shaped structure, and the central axis of the second extraction tube 222 is located inside the receiving groove;

[0025] During use, after the height position of the extraction component is adjusted, the reagent bottle is placed inside the receiving groove inside the base 100 (the extraction head 223 is inserted into the reagent bottle). At this time, the user can abut the end of the damping hinged claw 225 away from the hinge 224 against the outer surface of the reagent bottle. At this time, the three claws 225 can fix the reagent bottle to the lower end of the extraction tube 222 and the bottom of the receiving groove. When mesenchymal stem cells are extracted, the extracted reagent bottle can be effectively fixed, which not only improves the stability and accuracy of the operation, but also provides reliable protection for the extraction process, fully reflects its superiority and convenience in practical applications, and brings better results for exosome extraction.

[0026] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A flexible exosome extractor, comprising: Base (100), working plate (200) and extraction assembly, characterized in that a receiving groove is formed by downward depression on the upper side surface of the base (100), two guide rods (130) are symmetrically installed at the front side edge of the upper side surface of the base (100), and two screw rod slides (140) are symmetrically installed on the rear side surface of the base (100); The working plate (200) is installed above the base (100) through the guide rods (130) and the screw rod slides (140). A test tube rack (210) and a control console (230) are installed on the upper side surface of the working plate (200). Four extraction assemblies are installed on the upper side surface of the working plate (200). The extraction assembly includes: a centrifugal pump (220), a first extraction tube (221), a second extraction tube (222), a grasping assembly and an extraction head (223); The first extraction tube (221) is installed on the upper side surface of the centrifugal pump (220), and the second extraction tube (222) is installed through the working plate (200) on the lower side surface of the centrifugal pump (220). An extraction head (223) and a grasping assembly are installed at one end of the second extraction tube (222) away from the working plate (200).

2. The exosome extractor with flexible operation as claimed in claim 1, characterized in that: A universal wheel (110) with a self-locking structure is installed at each of the four corners of the lower side surface of the base (100). A baffle (120) is installed at the center position inside the receiving groove of the base (100). The two guide rods (130) penetrate through the left side edge of the upper side surface of the working plate (200).

3. The exosome extractor with flexible operation as claimed in claim 2, characterized in that: The rear side surface of the working plate (200) is slidably connected to the screw rod slide (140). The length and width of the working plate (200) are the same as the length and width of the base (100). A test tube rack (210) is installed at the center position of the rear side edge of the upper side surface of the working plate (200), and a control console (230) is installed at the center position of the front side edge of the upper side surface of the working plate (200).

4. The exosome extractor with flexible operation as claimed in claim 3, characterized in that: Two centrifugal pumps (220) are symmetrically installed on the left side edge and the right side edge of the upper side surface of the working plate (200). The first extraction tube (221) is installed at the outlet of the centrifugal pump (220). The first extraction tube (221) has a U-shaped structure with an opening downward. The second extraction tube (222) is installed through the working plate (200) at the outlet of the centrifugal pump (220).

5. The exosome extractor with flexible operation as claimed in claim 4, characterized in that: The grasping assembly includes: a hinge member (224) and a claw (225). An extraction head (223) is provided at one end of the second extraction tube (222) away from the working plate (200). Three hinge members (224) are evenly installed on the outer surface of the second extraction tube (222) away from the working plate (200). Three claws (225) are damped and hinged to the outer surface of the second extraction tube (222) through the three hinge members (224).

6. The exosome extractor with flexible operation as claimed in claim 5, characterized in that: The three claws (225) have a J-shaped structure, and the central axis of the second extraction tube (222) is inside the receiving groove.

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