Integrated magnetic biological detection instrument for detecting pathogenic bacteria

Abstract

The utility model provides an integrated magnetic biological detection instrument for detecting pathogenic bacteria, and relates to the technical field of magnetic biological detection instruments. A sample detection assembly of the detection instrument is arranged in a first cavity, the sample detection assembly comprises a solenoid and a sample rod, a sample can be placed on the part, sleeving the solenoid, of the sample rod, and the sample rod can detect pathogenic bacteria in the sample under the condition that the solenoid provides a stable magnetic field; the signal processing assembly is arranged in the second cavity, a signal acquisition board of the signal processing assembly can acquire and process detection signals of the sample rod on the pathogenic bacteria in the sample, and the signal acquisition board can transmit the processed detection signals to the main board for processing. The signal acquisition board, the mainboard, the sample rod and the solenoid are integrally arranged in the box body, so that the manual steps and the operation difficulty are reduced, the weight and the size of the detection instrument are reduced, and the convenience of the detection instrument is further improved to meet the rapid, simple and convenient on-site detection requirements.

Description

Technical Field

[0001] The present specification relates to the technical field of magnetic biological detection instruments, and in particular, to an integrated magnetic biological detection instrument for detecting pathogenic bacteria. Background Art

[0002] The magnetic biological detection method uses immunomagnetic bead technology to magnetically label pathogens to convert biological information into magnetic information, and then uses antigen-antibody immunotechnology to bind the magnetically labeled pathogens to the chip surface modified with pathogen antibodies, and through a magnetic sensor based on the giant magnetoresistance effect (GMR), the magnetic information is converted into electrical information to achieve the detection of pathogens. This method determines whether the sample contains pathogens by the presence or absence of chip signals, determines the type of pathogens by the type of specific antibodies modified on the chip, and quantifies the concentration of pathogens by signal intensity.

[0003] However, the above-mentioned magnetic biological detection method still needs to use a variety of equipment (such as magnetic field generators, high-precision digital source meters, etc.) to complete the high-sensitivity detection of pathogens. However, the equipment used has the disadvantages of being bulky and cumbersome to operate, which is not convenient to carry and deploy, and cannot meet the needs of fast and simple detection on site. Utility Model Content

[0004] The purpose of this specification is to provide an integrated magnetic biological detection instrument for pathogenic bacteria detection, which can overcome the above defects of existing magnetic biological detection equipment.

[0005] The embodiments of this specification are implemented as follows:

[0006] An integrated magnetic biological detection instrument for pathogenic bacteria detection, mainly comprising a box, a signal processing component and a sample detection component;

[0007] The box body is independently provided with a first chamber and a second chamber;

[0008] The sample detection assembly is disposed in the first chamber, and the sample detection assembly includes a solenoid and a sample rod, the sample rod is sleeved in the solenoid, the portion of the sample rod sleeved in the solenoid can be used to place a sample, and the portion of the sample rod sleeved in the solenoid can detect pathogenic bacteria in the sample under the condition that the solenoid provides a stable magnetic field;

[0009] The signal processing component is arranged in the second chamber, and the signal processing component includes a signal acquisition board and a main board, and the signal acquisition board is connected to the main board; the signal acquisition board is connected to one end of the sample rod sleeved on the solenoid, and the signal acquisition board can collect and process the detection signal of the sample rod on the pathogenic bacteria in the sample, and the signal acquisition board can transmit the processed detection signal to the main board for signal processing.

[0010] In some embodiments of the present specification, the portion of the sample rod sleeve disposed in the solenoid includes at least a connector, a detection circuit board provided with a magnetic biosensor, and two chip carriers; the detection circuit board is disposed between the two chip carriers, the detection circuit board is connected to the connector disposed at one end of the chip carrier, the connector is connected to the female port in the solenoid, and the detection circuit board can transmit the detection signal to the signal acquisition board through the connector; one of the chip carriers is provided with a through hole, the channel position of the through hole corresponds to the position of the magnetic biosensor on the detection circuit board, and the through hole cooperates with one side of the detection circuit board to form a sample groove, and the sample groove is used to place the sample.

[0011] In some embodiments of the present specification, the sample rod also includes a guide column, which is connected to an end of the chip carrier away from the connector, and the guide column has a plurality of guide protrusions. The inner wall of the solenoid is provided with guide grooves adapted to the plurality of guide protrusions, and the guide column is connected to the solenoid through the cooperation of the guide protrusions and the guide grooves.

[0012] In some embodiments of the present specification, the guide protrusion is shaped like a prism, the length direction of the guide protrusion is the same as the length direction of the guide column, at least one of the guide protrusions is provided with a slide groove along its length direction, the solenoid is provided with a locking protrusion, and the slide groove is slidably connected to the locking protrusion.

[0013] In some embodiments of the present specification, a U-shaped handle is provided at one end of the guide column away from the chip carrier, and a mounting hole is provided on the box body corresponding to the position of the sample rod, and an end of the guide column close to the U-shaped handle can extend to the outside of the box body through the mounting hole.

[0014] In some embodiments of the present specification, the signal processing component also includes a programmable current source, which is connected to the signal acquisition board and the solenoid. The signal acquisition board controls the current of the programmable current source through the connection, and the programmable current source can provide the solenoid with the required working current.

[0015] In some embodiments of the present specification, a third chamber and a heat dissipation component disposed in the third chamber are further provided in the casing, the first chamber and the third chamber are disposed on opposite sides of the second chamber, the first chamber is disposed on one side of the casing, and the third chamber is disposed on the other side of the casing away from the first chamber, and the heat dissipation component can dissipate the heat generated by the signal processing component and the sample detection component out of the casing.

[0016] In some embodiments of the present specification, a plurality of partition plates are arranged in parallel in the second chamber, the plurality of partition plates are respectively installed with the programmable current source, the signal acquisition board and the main board, and the gap between two adjacent partition plates is respectively connected to the first chamber and the third chamber.

[0017] In some embodiments of the present specification, an AC / DC power supply is also provided in the box body, and the AC / DC power supply is arranged on the side wall of the second chamber close to the box body along the height direction of the box body, and the AC / DC power supply can convert the external power supply of the box body into the DC power required by the signal processing component.

[0018] In some embodiments of the present specification, a channel switching switch is also embedded in the outer wall of the box, and the channel switching switch is connected to the signal acquisition board. The channel switching switch can control the signal acquisition board to collect detection signals of different pathogens.

[0019] The embodiments of this specification have at least the following advantages or beneficial effects:

[0020] This specification proposes an integrated magnetic biological detection instrument for pathogenic bacteria detection, which integrates the signal acquisition board, main board, sample rod and solenoid in the box, thereby reducing manual steps and operating difficulties, improving the detection speed, thereby reducing the knowledge requirements for professional medical personnel, facilitating non-professionals to perform detection, and at the same time, reducing the weight and volume of the detection instrument. The above two aspects improve the convenience of the above-mentioned detection instrument to meet the needs of fast and simple detection on site. Moreover, arranging the solenoid and the signal acquisition board in separate chambers can effectively prevent the weak signal collected by the signal acquisition board from being interfered with by the electromagnetic field, so as to further improve the accuracy of signal processing. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of this specification, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present specification and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 A schematic diagram of the structure of an integrated magnetic biological detection instrument for pathogenic bacteria detection provided in this specification;

[0023] Figure 2 A schematic diagram of the structure of an integrated magnetic biological detection instrument for pathogenic bacteria detection provided in this specification;

[0024] Figure 3 The figure shows the schematic diagram of the structure of the sample rod provided in this manual;

[0025] Figure 4 Shown is a schematic diagram of the structure of the solenoid provided in this specification;

[0026] Figure 5 Shown is a schematic diagram of the setting position of the locking protrusion provided in this manual.

[0027] Icons: 1-box, 2-handle, 3-display, 4-channel switch, 5-serial port, 6-handle reserved interface, 7-fan, 8-programmable current source, 9-mainboard, 10-AC / DC power supply, 11-sample rod, 12-solenoid, 13-chassis partition, 14-signal acquisition board, 15-connector, 16-detection circuit board, 17-chip carrier, 18-slide, 19-U-shaped handle, 20-guide column, 21-locking protrusion. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solutions and advantages of the embodiments of this specification more clear, the technical solutions in the embodiments of this specification will be clearly and completely described below in conjunction with the drawings in the embodiments of this specification. Obviously, the described embodiments are part of the embodiments of this specification, not all of the embodiments. The components of the embodiments of this specification described and shown in the drawings here can be arranged and designed in various different configurations.

[0029] Therefore, the following detailed description of the embodiments of the present specification provided in the accompanying drawings is not intended to limit the scope of the present specification to be protected, but merely represents selected embodiments of the present specification. Based on the embodiments in the present specification, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present specification.

[0030] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0031] In the description of the embodiments of this specification, it should be noted that if the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the drawings, or the orientation or position relationship in which the product of the application is usually placed when in use. It is only for the convenience of describing this specification and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as a limitation on this specification. In addition, if the terms "first", "second", "third", etc. appear, they are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0032] In addition, the terms "horizontal", "vertical", "overhanging" and the like do not mean that the components must be absolutely horizontal or overhanging, but can be slightly tilted. For example, "horizontal" only means that its direction is more horizontal than "vertical", and does not mean that the structure must be completely horizontal, but can be slightly tilted.

[0033] In the description of the embodiments of this specification, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal connection of two components. For ordinary technicians in this field, the specific meanings of the above terms in this specification can be understood according to specific circumstances.

[0034] Example 1

[0035] Please refer to Figure 1 , This embodiment proposes an integrated magnetic biological detection instrument for pathogenic bacteria detection, which mainly includes a box 1, a signal processing component and a sample detection component;

[0036] The box body 1 is independently provided with a first chamber and a second chamber;

[0037] The sample detection assembly is disposed in the first chamber, and the sample detection assembly includes a solenoid 12 and a sample rod 11, wherein the sample rod 11 is sleeved in the solenoid 12, and the portion of the sample rod 11 sleeved in the solenoid 12 can be used to place a sample, and the portion of the sample rod 11 sleeved in the solenoid 12 can detect pathogenic bacteria in the sample under the condition that the solenoid 12 provides a stable magnetic field;

[0038] The signal processing component is arranged in the second chamber, and the signal processing component includes a signal acquisition board 14 and a main board 9, and the signal acquisition board 14 is connected to the main board 9; the signal acquisition board 14 is connected to the sample rod 11 which is sleeved on one end of the solenoid 12, and the signal acquisition board 14 can collect and process the detection signal of the sample rod 11 on the pathogenic bacteria in the sample, and the signal acquisition board 14 can transmit the processed detection signal to the main board 9 for signal processing.

[0039] In this embodiment, a display hole and a display element 3 are provided on the front side wall of the box body 1. The display element 3 can be installed in the display hole through a screen installation plate and screws, and the display side of the display element 3 faces the outside of the box body 1 from the display hole, so that the user can understand the detection status of the above-mentioned detection instrument and the sample detection result through the display element 3. The above-mentioned display element 3 is connected to the main board 9.

[0040] In this embodiment, a handle 2 is provided on the outer side of the box body 1, and the handle 2 can be provided on the left and right sides of the box body 1 (in order to Figure 1 The front, rear, left and right directions shown are the corresponding directions proposed in this embodiment), and the handle 2 is arranged on the outside of the box body 1 from the rear to the front, so as to facilitate carrying and adjusting the position of the box body 1. The handle 2 is fixed to the outside of the box body 1 by three cross recessed countersunk screws, and the height of the handle 2 is consistent with the height of the box body 1, and the edge of the handle 2 is arc-shaped.

[0041] In this embodiment, a handle reserved interface 6 is further provided on the outside of the box body 1 , and can be preferably provided on the outside of the top wall of the box body 1 .

[0042] In this embodiment, a group of connection serial ports 5 are also provided on the front side wall of the box body 1, and the group of connection serial ports 5 include at least several USB interfaces, several RS23 interfaces, a power indicator light and an alarm light (the indicator colors of the power indicator light and the alarm light may be the same or different), and the above-mentioned connection serial ports 5 are connected to the mainboard 9.

[0043] In this embodiment, the signal acquisition board 14 can collect the detection signal of pathogenic bacteria from the detection circuit board 16 provided with a magnetic biosensor, amplify and reduce the noise of the detection signal, and transmit the amplified and reduced noise detection signal to the main board 9.

[0044] In this embodiment, the first chamber and the second chamber are separated by a chassis partition 13, and there is only a frame separation, not a closed separation, which can keep the air unobstructed.

[0045] In this embodiment, the size of the box 1 can be 342mm×120mm×210mm (length×width×height). It can be seen that the instrument can effectively reduce the weight and volume of the detection instrument by integrating the signal acquisition board 14, the main board 9, the sample rod 11 and the solenoid 12 in the box 1, thereby improving the convenience of the above-mentioned detection instrument to meet the needs of fast and simple detection on site.

[0046] Moreover, the shell of the box 1 is all made of aluminum alloy for closed design, and the ventilation holes are made of honeycomb metal holes, which have the ability to shield external electromagnetics. The solenoid 12 and the signal acquisition board 14 are arranged in separate chambers, which can effectively prevent the weak signal collected by the signal acquisition board 14 from being interfered by the electromagnetic field, so as to further improve the accuracy of signal processing.

[0047] In this embodiment, the portion of the sample rod 11 sleeved in the solenoid 12 at least includes a connector 15, a detection circuit board 16 provided with a magnetic biosensor, and two chip carriers 17;

[0048] The detection circuit board 16 is disposed between the two chip carriers 17, the detection circuit board 16 is connected to the connector 15 disposed at one end of the chip carrier 17, the connector 15 is connected to the mounting female port in the solenoid 12, and the detection circuit board 16 can transmit the detection signal to the signal acquisition board 14 through the connector 15;

[0049] One of the chip carriers 17 is provided with a through hole, the channel position of the through hole corresponds to the position of the magnetic biosensor on the detection circuit board 16, and the through hole cooperates with one side of the detection circuit board 16 to form a sample groove for placing a sample.

[0050] In this embodiment, the sample is preferably a magnetically labeled pathogenic bacteria solution sample.

[0051] In this embodiment, the chip carrier 17 has a first semicircular portion, a carrier portion and a second semicircular portion connected in sequence. The first semicircular portion and the second semicircular portion are axially symmetrically arranged at both ends of the carrier portion along the length direction of the carrier portion. The first semicircular portion, the carrier portion and the second semicircular portion cooperate to form a "concave" shaped structure.

[0052] In this embodiment, the first semicircular portions of the two chip carriers 17 cooperate to form a circular mounting seat, the connector 15 is arranged on the side of the circular mounting seat away from the carrier portion, and a mounting female port is provided in the solenoid 12, which is adapted to the connector 15, that is, one end of the sample rod 11 provided with the connector 15 is fixedly connected to the solenoid 12 through the mounting female port.

[0053] In this embodiment, the two chip carriers 17 are symmetrically arranged in the plane where the carrier part is located, and a detection circuit board 16 is arranged between the two chip carriers 17, so that the detection circuit board 16 can not only detect the sample under the stable magnetic field provided by the solenoid 12, but also further protect and fix the detection circuit board 16.

[0054] In this embodiment, a through hole is provided on the carrier portion of the chip carrier 17 facing the top side of the box body 1, and the setting position of the through hole corresponds to the position of the magnetic biosensor on the detection circuit board 16, that is, the magnetic biosensor serves as the bottom wall of the sample groove, and cooperates with the through hole of the chip carrier 17 to form a sample groove, and the sample groove can be used to place a liquid sample.

[0055] In this embodiment, the sample rod 11 further includes a guide post 20, which is connected to the end of the chip carrier 17 away from the connector 15, and has a plurality of guide protrusions. The inner wall of the solenoid 12 is provided with guide grooves adapted to the plurality of guide protrusions, and the guide post 20 is connected to the solenoid 12 through the cooperation of the guide protrusions and the guide grooves. The provision of the guide post 20 can avoid the phenomenon of positional deviation when the sample rod 11 is inserted into the solenoid 12, reduce the difficulty of operation, and make it more convenient.

[0056] In this embodiment, the guide protrusion is shaped like a prism, and the length direction of the guide protrusion is the same as the length direction of the guide column 20. One of the guide protrusions is provided with a slide groove 18 along its length direction, and the solenoid 12 is provided with a locking protrusion 21, and the slide groove 18 is slidably connected to the locking protrusion 21.

[0057] It should be noted here that since the solenoid 12 is installed in the box body 1, a corresponding installation entrance is opened at the position of the box body 1 corresponding to the entrance of the solenoid 12. The installation entrance is compatible with the guide column 20, and a locking protrusion 21 is provided at the corresponding position of the installation entrance. That is, the locking protrusion 21 can be intermittently set at the position of the installation entrance and the entrance of the solenoid 12, and can also be continuously set at the position of the installation entrance and the entrance of the solenoid 12.

[0058] Alternatively, the locking protrusion 21 is only provided at the position of the installation entrance.

[0059] By providing a slide groove 18 on the guide protrusion, the placement direction of the sample rod 11 in the solenoid 12 can be fixed, that is, the chip carrier 17 provided with the sample groove can always be in an upward state, so as to successfully detect the pathogens in the sample (including the presence, type and concentration of pathogens).

[0060] In this embodiment, the sample rod 11 is a detection device for carrying pathogenic bacteria-magnetic label samples, wherein the magnetic label is an experimental drug, the main type of which is ferroferric oxide magnetic beads, and the pathogenic bacteria-magnetic label sample (or magnetically labeled pathogenic bacteria) is a sample in which magnetic beads are attached to pathogenic bacteria through antigen-antibody immunoassay technology.

[0061] In this embodiment, a U-shaped handle 19 is provided at one end of the guide column 20 away from the chip carrier 17, and a mounting hole is provided at a position of the box body 1 corresponding to the sample rod 11. The end of the guide column 20 close to the U-shaped handle 19 can extend to the outside of the box body 1 through the mounting hole, so as to facilitate taking the sample rod 11.

[0062] In this embodiment, the signal processing component also includes a programmable current source 8, which is connected to the signal acquisition board and the solenoid. The signal acquisition board 14 controls the current of the programmable current source 8 through the connection. The programmable current source 8 can provide the solenoid 12 with the required working current. For example, the output current of the programmable current source 8 can be 0A-4A, and the maximum allowable error is ±5mA.

[0063] In this embodiment, a third chamber and a heat dissipation component arranged in the third chamber are further provided in the box body 1, the first chamber and the third chamber are arranged on opposite sides of the second chamber, the first chamber is arranged on one side of the box body 1, and the third chamber is arranged on the other side of the box body 1 away from the first chamber, and the heat dissipation component can dissipate the heat generated by the signal processing component and the sample detection component to the outside of the box body 1.

[0064] By arranging the heat dissipation component and the sample detection component on both sides of the signal processing component, the space in the box body 1 can be rationally arranged, the space utilization rate can be improved, and the demand for miniaturization can be met.

[0065] In this embodiment, the above-mentioned heat dissipation component includes a fan 7 and a rotating shaft. The fan 7 can rotate about the rotating shaft, and the length direction of the rotating shaft is the same as the direction from the second chamber to the third chamber. The fan 7 adopts an outward wind design. When the fan is in working state, the air flow direction in the box body 1 is from the first chamber to the second chamber and then to the third chamber, so as to enhance the heat dissipation effect of the heat dissipation component.

[0066] In this embodiment, a plurality of partition plates are arranged in parallel in the second chamber, and the plurality of partition plates are respectively installed with the programmable current source 8, the signal acquisition board 14 and the main board 9, and the gap between two adjacent partition plates is respectively connected to the first chamber and the third chamber.

[0067] In this embodiment, the programmable current source 8 includes a stacked programmable current source 8 circuit board and a fixed carrier; the main board 9 includes a stacked circuit board, a fixed carrier and a display driver board, the model of the circuit board is M219SE3.5-J1900, the maximum memory capacity is 2GB, the display interface is HDMI+VGA, and the model of the display driver board is EDP LC-2A1b-3A. The programmable current source 8, the main board 9 and the signal acquisition board 14 can adopt a plug-in card design to facilitate their installation with the partition board.

[0068] In this embodiment, by arranging a plurality of partition plates in parallel with the wind direction of the fan 7 , the heat dissipation effect of the second chamber can be effectively improved.

[0069] In this embodiment, an AC / DC power supply 10 is further provided in the box 1. The AC / DC power supply 10 is provided on the side wall of the second chamber close to the box 1 along the height direction of the box 1, and the AC / DC power supply 10 can convert the external power supply of the box 1 into the DC power required by the signal processing component. The AC / DC power supply 10 can convert the external 220V AC power into 12V / 5V DC power.

[0070] In this embodiment, a channel switching switch 4 is also embedded in the outer wall of the box body 1, and the channel switching switch 4 is connected to the signal acquisition board 14. The channel switching switch 4 can control the signal acquisition board 14 to collect detection signals of different types of pathogens.

[0071] In this embodiment, the channel switching switch 4 is a self-resetting circular button switch with a thread, and the model is KAN51-1B1-RF3.3.

[0072] It should be noted that a plurality of channels are provided on the signal acquisition board 14 , and the channel switching switch 4 can control the opening state of the above channels.

[0073] In this embodiment, the solenoid 12 can generate a stable and uniform magnetic field with a magnetic field strength of 0Oe-158Oe, providing an excitation magnetic field for the magnetic biosensor chip, and the model may preferably be CHL10-150.

[0074] In this embodiment, the side wall and the partition plate of the box body 1 are made of aluminum 5052, the surface treatment of the box body 1 is overall sandblasting black anodizing, and the surface treatment of the partition plate is overall primary color anodizing.

[0075] The above are only preferred embodiments of this specification and are not intended to limit this specification. For those skilled in the art, this specification may have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this specification shall be included in the protection scope of this specification.

Claims

1. An integrated magnetic biological detection instrument for pathogenic bacteria detection, characterized in that: It includes a box, a signal processing component and a sample detection component; The box body is independently provided with a first chamber and a second chamber; The sample detection assembly is disposed in the first chamber, and the sample detection assembly includes a solenoid and a sample rod, a portion of the sample rod is sleeved in the solenoid, a portion of the sample rod sleeved in the solenoid can hold a sample, and the sample rod can detect pathogenic bacteria in the sample under the condition that the solenoid provides a stable magnetic field; The signal processing component is arranged in the second chamber, and the signal processing component includes a signal acquisition board and a main board, and the signal acquisition board is connected to the main board; the signal acquisition board is connected to one end of the sample rod sleeved on the solenoid, and the signal acquisition board can collect and process the detection signal of the sample rod on the pathogenic bacteria in the sample, and the signal acquisition board can transmit the processed detection signal to the main board for signal processing.

2. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 1, characterized in that: The portion of the sample rod sleeved in the solenoid at least includes a connector, a detection circuit board provided with a magnetic biosensor, and two chip carriers; The detection circuit board is arranged between the two chip carriers, the detection circuit board is connected to the connector arranged at one end of the chip carrier, the connector is connected to the female port in the solenoid, and the detection circuit board can transmit the detection signal to the signal acquisition board through the connector; One of the chip carriers is provided with a through hole, the channel position of the through hole corresponds to the position of the magnetic biosensor on the detection circuit board, and the through hole cooperates with one side of the detection circuit board to form a sample groove, and the sample groove is used to place the sample.

3. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 2, characterized in that: The sample rod also includes a guide column, which is connected to one end of the chip carrier away from the connector. The guide column has a plurality of guide protrusions. The inner wall of the solenoid is provided with guide grooves that are compatible with the plurality of guide protrusions. The guide column is connected to the solenoid through the cooperation of the guide protrusions and the guide grooves.

4. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 3, characterized in that: The guide protrusion is shaped like a prism, and the length direction of the guide protrusion is the same as the length direction of the guide column. One of the guide protrusions is provided with a slide groove along its length direction, and the solenoid is provided with a locking protrusion, and the slide groove is slidably connected to the locking protrusion.

5. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 3 or 4, characterized in that: A U-shaped handle is provided at one end of the guide column away from the chip carrier, and a mounting hole is provided at a position of the box body corresponding to the sample rod, and an end of the guide column close to the U-shaped handle can extend to the outside of the box body through the mounting hole.

6. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 1, characterized in that: The signal processing component also includes a programmable current source, which is connected to the signal acquisition board and the solenoid. The signal acquisition board controls the current of the programmable current source through the connection, and the programmable current source can provide the solenoid with the required working current.

7. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 6, characterized in that: The box body is also provided with a third chamber and a heat dissipation component arranged in the third chamber. The first chamber and the third chamber are arranged on opposite sides of the second chamber. The first chamber is arranged on one side of the box body, and the third chamber is arranged on the other side of the box body away from the first chamber. The heat dissipation component can dissipate the heat generated by the signal processing component and the sample detection component out of the box body.

8. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 7, characterized in that: A plurality of partition plates are arranged in parallel in the second chamber, and the plurality of partition plates are respectively installed with the programmable current source, the signal acquisition board and the main board, and the gap between two adjacent partition plates is respectively connected to the first chamber and the third chamber.

9. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 1 or 7, characterized in that: An AC / DC power supply is also provided in the box body. The AC / DC power supply is arranged on the side wall of the second chamber close to the box body along the height direction of the box body, and the AC / DC power supply can convert the external power supply of the box body into the DC power required by the signal processing component.

10. The integrated magnetic biological detection instrument for pathogenic bacteria detection according to claim 2, characterized in that: A channel switching switch is also embedded in the outer wall of the box body, and the channel switching switch is connected to the signal acquisition board. The channel switching switch can control the signal acquisition board to collect detection signals of different types of pathogens.

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