Isolated organ storage container and perfusion system

Abstract

The utility model discloses an isolated organ storage container and a perfusion system, and the isolated organ storage container comprises a container main body which is used for accommodating an isolated organ; the sealing cover assembly is arranged at the top of the container main body and is used for sealing the container main body; the air bag assembly penetrates through the bottom of the container main body and is used for extruding the isolated organ in a reciprocating manner; wherein the air bag assembly comprises an air bag body and an air bag support capable of adjusting the height of the air bag, and the air bag body is fixedly connected to the air bag support. The height of the air bag assembly is adjustable, so that the device can adapt to isolated organs of different sizes, an excellent extrusion effect is achieved, and diaphragm movement is better simulated.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical instruments, and in particular relates to an isolated organ storage container and a perfusion system containing the isolated organ storage container. Background Art

[0002] Organ transplantation refers to the technology of introducing an organ from an individual into a part of the individual or another individual through surgery or other methods to replace the original part that has lost its function. Since organ transplantation requires the transplantation of living organs, it is a prerequisite for the success of transplantation that the organ for transplantation maintains its complete anatomical structure and activity from the time it is removed from the donor's body until its main blood vessels are connected to the recipient's blood vessels. Therefore, the preservation of ex vivo organs is a key link in organ transplantation.

[0003] Currently, common methods for preserving isolated organs include low-temperature static freezing and low-temperature perfusion. Among them, low-temperature perfusion preservation is to place the isolated organ in a certain storage container, connect the corresponding perfusion equipment, and continuously perfuse the isolated organ. However, long-term fixation of organs in storage containers can easily cause organ ischemia. At present, by setting a breathing airbag under the isolated organ storage container, it is possible to simulate the periodic squeezing of the liver by the diaphragm during respiration, and prevent ischemia of the static part of the organ caused by long-term fixation. However, due to the differences in the sizes of isolated organs, the existing breathing airbags cannot be adjusted accordingly according to the differences in the isolated organs, resulting in poor squeezing effect. Utility Model Content

[0004] In view of this, it is necessary for the utility model to provide an isolated organ storage container, the height of the airbag assembly of the isolated organ storage container is adjustable, so that the height of the airbag assembly can be adjusted according to the size of the isolated organ, thereby ensuring the squeezing effect on the isolated organ.

[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0006] The utility model provides an in vitro organ storage container, comprising:

[0007] A container body, which is used to contain the isolated organ;

[0008] A sealing cover assembly, which is arranged on the top of the container body and is used to seal the container body;

[0009] and an air bag assembly, which passes through the bottom of the container body and is used for reciprocatingly squeezing the isolated organ;

[0010] The airbag assembly comprises an airbag body and an airbag bracket with adjustable airbag height, and the airbag body is fixedly connected to the airbag bracket.

[0011] In a further solution, the bottom of the container body is an eccentric funnel structure, a liquid outflow hole is provided at the lowest point of the bottom surface of the container body, and a plurality of annular protrusions are provided inside the liquid outflow hole.

[0012] In a further solution, an airbag hole is provided on the bottom surface of the container body, and the airbag body can pass through the airbag hole.

[0013] In a further embodiment, the isolated organ storage container further comprises an organ pad for supporting the isolated organ, wherein the organ pad comprises a middle portion and ears arranged around the middle portion and protruding, and the ears are provided with fixing holes;

[0014] A fixing pin is provided on the top surface of the container body, and the fixing pin is matched with the fixing hole so that the organ pad is suspended inside the container body.

[0015] In a further embodiment, a first finger-shaped portion is provided in the middle of the organ pad, and the first finger-shaped portion is located between adjacent ears of the organ pad.

[0016] In a further embodiment, a second finger-shaped portion is provided in the middle of the organ pad, and the second finger-shaped portion extends from the middle of the organ pad toward the ear; a small hole is provided at an end of the second finger-shaped portion away from the middle of the organ pad.

[0017] In a further embodiment, the sealing cover assembly includes a base, the inner side surface of the base is provided with a guide groove, and a cover plate is slidably connected in the guide groove;

[0018] The base is provided with a pipeline clamp and a tie hole. The pipeline clamp is a structure with a small upper end and a large lower end, and the upper end of the pipeline clamp is connected to the outside.

[0019] In a further embodiment, a fixing plate for fixing the airbag assembly is provided at the bottom of the container body;

[0020] The airbag bracket includes a bottom plate, and side plates are vertically extended upward on opposite sides of the bottom plate, and the side plates are provided with vertical strip holes; the airbag bracket also includes an ear plate, and the ear plate is fixedly connected to the bottom plate through the vertical strip holes;

[0021] The ear plate is fixedly connected to the fixing plate.

[0022] In a further solution, the ear plate is threadedly fastened to the base plate.

[0023] The utility model further provides an isolated organ perfusion system, which comprises the above-mentioned isolated organ storage container.

[0024] Beneficial effects of the utility model:

[0025] The in vitro organ storage container of the utility model has an adjustable height of the airbag component, so that it can adapt to in vitro organs of different sizes, achieve an excellent squeezing effect, and thus better simulate the movement of the diaphragm. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a schematic diagram of the structure of an in vitro organ storage container in a preferred embodiment of the utility model;

[0027] Figure 2 for Figure 1 Schematic diagram of the exploded structure of the isolated organ storage container;

[0028] Figure 3 for Figure 2 A schematic structural diagram of the middle sealing cover assembly 1;

[0029] Figure 4 for Figure 3 A schematic structural diagram of the middle base 11;

[0030] Figure 5 for Figure 2 A schematic diagram of the structure of the middle organ pad 2;

[0031] Figure 6 for Figure 2 A schematic diagram of the structure of the container body 3;

[0032] Figure 7 for Figure 6 A schematic cross-sectional structure diagram of the container body 3;

[0033] Figure 8 for Figure 2 A schematic structural diagram of the middle airbag assembly 4.

[0034] In the figure: 1-sealing cover assembly, 11-base, 111-guide groove, 112-pipeline bayonet, 113-tie hole, 114-groove; 12-cover plate, 121-protrusion; 2-organ pad, 21-middle part, 22-ear part, 221-fixing hole, 23-first finger-shaped part, 24-second finger-shaped part, 241-small hole; 3-container body, 31-liquid outflow hole, 311-annular protrusion, 32-airbag hole, 33-fixing plate, 34-fixing pin; 4-airbag assembly, 41-airbag body, 42-airbag bracket, 421-bottom plate, 422-side plate, 423-vertical strip hole, 424-ear plate. DETAILED DESCRIPTION

[0035] The in vitro organ storage container provided by the present invention will be further described in detail below in conjunction with the accompanying drawings of the specification.

[0036] It should be noted that when a component is referred to as being "fixed to", "disposed on", or "installed on" another component, it can be directly on the other component or indirectly on the other component. However, when an element is referred to as being "connected to" or "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element. In addition, connection generally refers to the use for fixing, and the fixing here can be any conventional fixing method in the art, such as "threaded connection", "riveting", "welding", etc.

[0037] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings of the specification, and are only for the convenience of describing the embodiments of the utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed or operate in a specific orientation, and therefore cannot be understood as a limitation on the utility model.

[0038] This embodiment discloses an in vitro organ storage container, the structure of which is as follows: Figure 1 and Figure 2 As shown in the figure, the in vitro organ storage container includes a sealing cover assembly 1, an organ pad 2, a container body 3 and an airbag assembly 4. In actual use, a sterile film (not shown in the figure) needs to be laid between the organ pad 2 and the container body 3. The container body 3 is used to accommodate the in vitro organ, the organ pad 2 is suspended inside the container body 3, and the in vitro organ is placed on the organ pad 2; the sealing cover assembly 1 is used to seal the container body 3, and the airbag assembly 4 is arranged at the lower part of the container body 3, and is used to reciprocately squeeze the in vitro organ in the container body 3.

[0039] The sealing cover assembly 1 is disposed on the top of the container body 3 and is used to seal the container body 3. In this embodiment, the sealing cover assembly 1 includes a base 11 and a cover plate 12. Figure 3 and Figure 4The base 11 includes a flange that is tightly fitted with the container body 3 and extends vertically upward along the inner side edge of the flange. A guide groove 111 that forms a closed loop is provided on the inner side surface of the extended portion of the flange, and one side of the guide groove 111 is connected to the outside; the cover plate 12 is slidably connected in the guide groove 111, and a protrusion 121 is provided on one side of the cover plate 12, and the protrusion 121 passes through the side of the guide groove 111 that is connected to the outside, and the protrusion 121 is used to push and pull the cover plate 12; in this embodiment, the cover plate 12 is made of a transparent acrylic sheet, which is convenient for observing the situation inside the container body 3; the cover plate 12 is pushed and pulled by the protrusion 121, and the cover plate 12 slides in the guide groove 111 of the base 11 until it is sealed, thereby reducing the heat evaporation and water evaporation of the isolated organ. Furthermore, a plurality of pipeline bayonet 112 are provided on the flange extension portion of the base 11, such as Figure 4 As shown, the pipeline bayonet 112 is a structure with a large lower end and a small upper end, and the upper end is connected to the outside; a corresponding tie hole 113 is provided corresponding to the pipeline bayonet 112, and the tie hole 113 is provided on the flange of the base 11. The pipeline bayonet 112 is used to place the pipeline, so that the operator can adjust the direction of the pipeline according to the actual size of the isolated organ; the tie hole 113 is used to fix the corresponding pipeline. Specifically, the design of the pipeline bayonet 112 is convenient for adapting to fix different pipelines and flexibly adjusting the direction of the pipeline; for example, when the pipeline needs to be lifted, the pipeline can be directly clamped at the upper end of the pipeline bayonet 112, and when the pipeline needs to be moved down, the pipeline can be placed at the lower end of the pipeline bayonet 112 and fixed with the tie through the tie hole 113. Further, a groove 114 is provided on the lower surface of the flange of the base 11, and the groove 114 is used to reserve space for the organ pad 2, so that when the sealing cover assembly 1 and the container body 3 are sealed, the sealing cover assembly 1 and the container body 3 fit smoothly.

[0040] For further information, see Figure 5In this embodiment, the material of the organ pad 2 is medical grade silicone, and its structure includes a middle part 21 and ear parts 22. The ear parts 22 are arranged around the middle part 21 and protrude from the middle part 21. In this embodiment, there are four ear parts 22, which are respectively arranged on the four sides of the middle part 21. A plurality of fixing holes 221 are provided on the ear parts 22. The fixing holes 221 hook the organ pad 2 on the container body 3, so that the organ pad 2 is suspended inside the container body 3. By selecting different fixing holes 221, the height of the organ pad 2 in the container body 3 can be adjusted. Specifically, the fixing holes 221 close to the inner side are selected for the isolated organs with smaller sizes, and the fixing holes 221 close to the outer side are selected for the isolated organs with larger sizes. Furthermore, a first finger-shaped portion 23 is provided in the middle of the organ pad 2. Specifically, a concave arc is formed between adjacent ears 22. The first finger-shaped portion 23 extends from the middle portion 21 to the concave arc, and the end away from the middle portion 21 is located at the concave arc. The first finger-shaped portion 23 is not connected to the ears 22, so that the ex vivo organ can be placed at the center of the organ pad 2 without deviation, and the partial area of ​​the organ pad 2 is prevented from twisting during the bending process, causing damage to the ex vivo organ. Furthermore, a second finger-shaped portion 24 is also provided in the middle portion 21 of the organ pad 2. The second finger-shaped portion 24 extends from the middle portion 21 near the center to the ears 22, as shown in FIG. Figure 5 As shown in , the end of the second finger-shaped portion 24 away from the middle portion 21 and the side adjacent to the end are not connected to the organ pad 2, so that when the isolated organ is placed at the center of the organ pad 2, the second finger-shaped portion 24 can play a role in diversion, that is, the perfusion fluid and ascites flowing out of the container body 3 naturally flow down from the organ pad 2. Further, two small holes 241 are provided at the end of the second finger-shaped portion 24 away from the middle portion 21. The small holes 241 are used to bind surgical sutures, so that the second finger-shaped portion 24 can be freely adjusted to bend upward to a certain extent, so as to ensure that the perfusion fluid flows down smoothly and play a certain supporting role on the edge of the isolated organ, thereby ensuring the stability of the isolated organ.

[0041] The structure of the container body 3 in this embodiment is as follows Figure 6 and Figure 7As shown in , the container body 3 is also provided with a flange, which corresponds to the flange of the base 11. A plurality of fixing pins 34 are provided on the flange of the container body 3, and the fixing pins 34 are adapted to the fixing holes 221 on the organ pad 2, and are used to hook the organ pad 2. The main body of the container body 3 is an eccentric funnel-shaped structure, wherein a liquid outflow hole 31 is provided at the lowest point of the bottom surface of the container body 3, so that the liquid flowing down from the organ pad 2 can flow out from the liquid outflow hole 31. In this embodiment, a plurality of annular protrusions 311 are provided on the inner wall of the liquid outflow hole 31 to facilitate the pipeline, the sterile membrane and the liquid outflow hole 31 to be more tightly sealed. Further, an airbag hole 32 is provided on the bottom surface of the container body 3, and the airbag assembly 4 passes through the airbag hole 32 to achieve the extrusion of the in vitro organ on the organ pad 2. In addition, in this embodiment, a fixing plate 33 is provided on the outside of the main body bottom of the container body 3, and the fixing plate 33 is used to fix the airbag assembly 4.

[0042] The structure of the airbag assembly 4 in this embodiment is as follows Figure 8 As shown in , it includes an airbag body 41 and an airbag bracket 42. The airbag body 41 is a cylindrical airbag in this embodiment, and the airbag bracket 42 includes a bottom plate 421, on which the airbag body 41 is fixed; side plates 422 are vertically extended upward on opposite sides of the bottom plate 421, and vertical strip holes 423 are provided on the side plates 422; the airbag bracket 42 also includes two ear plates 424, and the ear plates 424 are fixedly connected to the side plates 422 through the vertical strip holes 423. In this embodiment, the ear plates 424 and the side plates 422 are fastened by threads, and the ear plates 424 can adjust the height through the vertical strip holes 423, thereby realizing the height adjustment of the airbag body 41.

[0043] In the specific operation, taking the liver as an example, after laying the sterile film in the container body 3, select the appropriate suspension height of the organ pad 2 according to the size of the liver; close the sealing cover assembly 1 and the container body 3. Pull out the cover plate 12 through the protrusion 121, place the liver in the middle of the organ pad 2, and tie the surgical suture through the small hole 241 on the second finger-shaped part 24, adjust the curvature of the second finger-shaped part 24 to ensure the support of the liver and facilitate the smooth flow of liquid; fix the relevant pipelines through the pipeline bayonet 112 and the tie hole 113; and then push the cover plate 12 through the protrusion 121 to seal the container body 3. In addition, the airbag body 41 passes through the airbag hole 32 at the bottom of the container body 3, and adjusts the height of the airbag body 41 through the airbag bracket 42 according to the size of the liver, so that the airbag body 41 reciprocates and squeezes the lower surface of the liver through the sterile film and the organ pad 2 to simulate the movement of the diaphragm.

[0044] Furthermore, this embodiment also discloses an isolated organ perfusion system, which includes the isolated storage container described in this embodiment, and the isolated organ perfusion system also includes a perfusion device, and the perfusion device can be any instrument or device in the art that can achieve perfusion of an isolated organ. The perfusion device is connected to the isolated storage container through a corresponding pipeline.

[0045] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0046] The above-mentioned embodiments only express several implementation methods of the utility model, and the description is relatively specific and detailed, but it cannot be understood as limiting the scope of the utility model patent. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the utility model, which all belong to the protection scope of the utility model. Therefore, the protection scope of the utility model patent shall be based on the attached claims.

Claims

1. An in vitro organ storage container, characterized in that: include: A container body, which is used to contain the isolated organ; A sealing cover assembly, which is arranged on the top of the container body and is used to seal the container body; and an air bag assembly, which passes through the bottom of the container body and is used for reciprocatingly squeezing the isolated organ; The airbag assembly comprises an airbag body and an airbag bracket with adjustable airbag height, and the airbag body is fixedly connected to the airbag bracket.

2. The isolated organ storage container according to claim 1, characterized in that: The bottom of the container body is an eccentric funnel structure. A liquid outflow hole is provided at the lowest point of the bottom surface of the container body. A plurality of annular protrusions are provided inside the liquid outflow hole.

3. The isolated organ storage container according to claim 1, characterized in that: The bottom surface of the container body is provided with an airbag hole, and the airbag body can pass through the airbag hole.

4. The isolated organ storage container according to claim 1, wherein: The in vitro organ storage container further comprises an organ pad for supporting the in vitro organ, wherein the organ pad comprises a middle portion and ears arranged around the middle portion and protruding, and the ears are provided with fixing holes; A fixing pin is provided on the top surface of the container body, and the fixing pin is matched with the fixing hole so that the organ pad is suspended inside the container body.

5. The isolated organ storage container according to claim 4, characterized in that: A first finger-shaped portion is provided in the middle of the organ pad, and the first finger-shaped portion is located between adjacent ears of the organ pad.

6. The isolated organ storage container according to claim 4, characterized in that: A second finger-shaped portion is provided in the middle of the organ pad. The second finger-shaped portion extends from the middle of the organ pad toward the ear, and a small hole is provided at an end of the second finger-shaped portion away from the middle of the organ pad.

7. The isolated organ storage container according to claim 1, characterized in that: The sealing cover assembly comprises a base, the inner side surface of the base is provided with a guide groove, and a cover plate is slidably connected in the guide groove; The base is provided with a pipeline clamp and a tie hole. The pipeline clamp is a structure with a small upper end and a large lower end, and the upper end of the pipeline clamp is connected to the outside.

8. The isolated organ storage container according to claim 1, characterized in that: The airbag bracket includes a bottom plate, and side plates are vertically extended upward on opposite sides of the bottom plate, and the side plates are provided with vertical strip holes; the airbag bracket also includes an ear plate, and the ear plate is fixedly connected to the bottom plate through the vertical strip holes; A fixing plate is provided at the bottom of the container body, and the fixing plate is fixedly connected to the ear plate.

9. The isolated organ storage container according to claim 8, characterized in that: The ear plate is threadedly fastened to the base plate.

10. An isolated organ perfusion system, characterized in that: It comprises the isolated organ storage container according to any one of claims 1 to 9.

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