Dissolution device for nano preparation analysis

Abstract

The utility model belongs to the technical field of preparation dissolution, and discloses a dissolution device for nano preparation analysis, the dissolution device comprises a heating box, the inner wall of the top end of the heating box is slidably sleeved with a limiting box plate, four corners of the bottom of the heating box are fixedly provided with supporting legs, and inner cavities of two sides of the limiting box plate are provided with round holes in a penetrating manner; the two sides of the limiting box plate are slidably sleeved with dissolution cups through round holes in a penetrating manner; by means of the arranged heating box, main body bearing can be conducted on the structure on the heating box, the limiting box plate and the heating base are used for achieving the limiting bearing and heating effects on a dissolution cup used for the nano-drug preparation, and by means of the arranged screw rod, the I-shaped rotating rod, the tooth groove ring, the gear, the rotating shaft and the motor, after a round of preparation dissolution is completed, the dissolution cup can be heated, and the dissolution cup can be conveniently separated. The vertical position of the limiting box plate is adjusted, so that the dissolution cup is convenient to take, and the extraction of a dissolved preparation and the dissolution work of a subsequent preparation are convenient.

Description

Technical Field

[0001] The present application relates to the technical field of preparation dissolution, and more specifically, to a dissolution device for nano preparation analysis. Background Art

[0002] Nanopreparations refer to nanoscale particles made from raw materials using nano-preparation technology, or nanoscale particles formed by combining raw materials with appropriate carrier materials, and the final drug preparations. Currently, when analyzing the drugs presented in nanopreparations, it is necessary to perform a dissolution process on the preparations.

[0003] After searching the publication number: CN215180107U, a dissolution device is disclosed, including a heating box, a dissolution cup, a lifting bracket, a support plate, a driving motor, a rotating shaft, a stirring paddle, a cover plate, a filter pressure plate, a through hole, a rotating bearing and an adsorption magnet, etc.; this application is aimed at some poorly soluble drugs, whose main components are ultra-finely ground and poorly soluble in water. After the tablets disintegrate, the main components will float on the liquid surface, which will affect the dissolution effect.

[0004] However, during use of this application, since the dissolution cup is placed in a storage type inside the heating box, it is inconvenient to take out the dissolution cup after the dissolution of the preparation inside the dissolution cup is completed, which makes it inconvenient to extract the preparation after dissolution and the subsequent dissolution of the preparation.

[0005] In order to solve the above problems, the present application provides a dissolution device for nanoformulation analysis. Utility Model Content

[0006] The present application provides a dissolution device for nanoformulation analysis using the following technical solution:

[0007] A dissolution device for analyzing nano-preparations, comprising a heating box, wherein the inner wall at the top of the heating box is slidably sleeved with a limit box plate, and legs are fixedly installed at the four corners of the bottom of the heating box, the inner cavities on both sides of the limit box plate are penetrated with round holes, and dissolution cups are penetrated and slidably sleeved with the two sides of the limit box plate through the round holes, the outer wall of the bottom end of each dissolution cup contacts a heating base, and the heating base is arranged on the inner wall of the bottom end of the heating box, the central inner cavity of the limit box plate is penetrated with a screw, the screw is located between two dissolution cups, and the bottom of the screw is fixedly connected with an I-shaped rotating rod, the I-shaped rotating rod is penetrated and slidably sleeved at the center position of the bottom end of the heating box, and the outer wall of the top end of the I-shaped rotating rod is circumferentially opened with a toothed groove ring, one side end of the toothed groove ring is meshed with a gear, the bottom of the gear is fixedly connected with a rotating shaft, the rotating shaft is penetrated and movably sleeved on the bottom end of the heating box, and the bottom of the rotating shaft is connected with a motor, and the motor is fixedly installed at the bottom of the heating box.

[0008] Through the above technical solution, the I-shaped rotating rod realizes the limited sliding receiving function of the screw rod.

[0009] Furthermore, each of the heating bases comprises a metal seat fixedly mounted on the inner wall of the bottom end of the heating box, and an electric heating wire is arranged inside the metal seat.

[0010] Through the above technical solution, the heating base facilitates the support and heating of the dissolution cup.

[0011] Furthermore, a limiting plate is fixedly installed on the top of the screw rod, the limiting plate is located on the top of the limiting box plate, and the limiting plate and the limiting box plate are not connected.

[0012] Through the above technical solution, the limiting plate realizes the limiting effect on the upper movable position of the limiting box plate.

[0013] Furthermore, the outer walls on one side of the two dissolution cups facing away from each other at the top ends are fixedly connected with cup ear blocks, and the two cup ear blocks are in contact with the top position of the limiting box plate.

[0014] Through the above technical solution, the cup ear block facilitates the extraction operation of the dissolution cup.

[0015] Furthermore, mounting blocks are fixedly connected to the middle of the outer walls on both sides of the bottom end of the heating box, and multi-section electric push rods are fixedly installed on the tops of the two mounting blocks. The driving ends of the tops of the two multi-section electric push rods are jointly provided with auxiliary components.

[0016] Through the above technical solution, the mounting block realizes the installation support function for the multi-section electric push rod.

[0017] Furthermore, the arc-shaped positions of the outer walls at the bottom ends of the two dissolution cups are in circular uniform contact with four contact balls, the outer wall of each contact ball is provided with a silicone pad layer, and the bottom end of each contact ball is fixedly connected to a fixing rod, each of the fixing rods is located on the outside of the heating base, and each fixing rod is fixedly installed on the inner wall of the bottom end of the heating box.

[0018] Through the above technical solution, the contact ball and the fixing rod achieve the auxiliary support effect of the dissolution cup.

[0019] In summary, this application includes the following beneficial technical effects:

[0020] The heating box provided can mainly support the upper structure thereof, and the limiting box plate and the heating base provided can realize the limiting support and heating of the dissolution cup used for the nano drug preparation, and the screw, I-shaped rotating rod, toothed ring, gear, rotating shaft and motor provided can realize the vertical position adjustment of the limiting box plate after a round of preparation dissolution is completed, so as to facilitate the taking of the dissolution cup, thereby facilitating the extraction of the preparation after dissolution and the subsequent dissolution of the preparation. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a schematic diagram of the overall structure of this application;

[0022] Figure 2 It is an overall side sectional view of the present application;

[0023] Figure 3 For this application Figure 2 A magnified view of the structure at center;

[0024] Figure 4 This is a schematic diagram of the local structure of this application.

[0025] Description of the numbers in the figure:

[0026] 1. Heating box; 2. Limit box plate; 3. Dissolution cup; 4. Heating base; 5. Screw; 6. I-shaped rotating rod; 7. Tooth ring; 8. Gear; 9. Rotating shaft; 10. Motor; 11. Limit plate; 12. Cup ear block; 13. Mounting block; 14. Multi-section electric push rod; 15. Contact ball; 16. Fixed rod. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application; obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments, and all other embodiments obtained by ordinary technicians in this field based on the embodiments in the present application without making creative work are within the scope of protection of the present application.

[0028] In the description of the present application, it should be noted that the terms "upper", "lower", "inner", "outer", "top / bottom" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as limiting the present application. In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0029] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "provided with", "set / connected", "connected", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0030] Example:

[0031] The present application discloses a dissolution device for analyzing nanoformulations. Figure 1 , Figure 2 and Figure 3 , including a heating box 1, the inner wall of the top of the heating box 1 is slidably sleeved with a limit box plate 2, and the four corners of the bottom of the heating box 1 are fixedly installed with legs, the inner cavities on both sides of the limit box plate 2 are penetrated with round holes, and the two sides of the limit box plate 2 are penetrated and slidably sleeved with dissolution cups 3 through the round holes, the outer wall of the bottom end of each dissolution cup 3 contacts a heating base 4, the heating base 4 is arranged on the inner wall of the bottom end of the heating box 1, the central inner cavity of the limit box plate 2 is penetrated and screwed with a screw 5, and the screw 5 is The bottom of the screw 5 is fixedly connected with an I-shaped rotating rod 6, which is slidably sleeved in the center of the bottom of the heating box 1, and the outer wall of the top of the I-shaped rotating rod 6 is circumferentially provided with a toothed ring 7, and a gear 8 is meshed at one side of the toothed ring 7, and a rotating shaft 9 is fixedly connected to the bottom of the gear 8, and the rotating shaft 9 is movably sleeved in the bottom of the heating box 1, and a motor 10 is connected to the bottom of the rotating shaft 9, and the motor 10 is fixedly installed at the bottom of the heating box 1;

[0032] Each heating base 4 includes a metal seat fixedly mounted on the inner wall of the bottom end of the heating box 1, and an electric heating wire is arranged inside the metal seat. A limit plate 11 is fixedly mounted on the top of the screw 5, and the limit plate 11 is located at the top of the limit box plate 2, and the limit plate 11 is not connected to the limit box plate 2. The outer walls of the two dissolution cups 3 on the side opposite to each other at the top are fixedly connected with cup ear blocks 12, and the two cup ear blocks 12 are in contact with the top position of the limit box plate 2.

[0033] See also Figure 1 , Figure 2 and Figure 4, the middle of the outer walls on both sides of the bottom of the heating box 1 are fixedly connected with mounting blocks 13, the tops of the two mounting blocks 13 are fixedly installed with multi-section electric push rods 14, and the driving ends of the tops of the two multi-section electric push rods 14 are jointly provided with auxiliary components, and the arc positions of the outer walls of the bottom ends of the two dissolution cups 3 are uniformly contacted with four contact balls 15 in a circumferential manner, and the outer wall of each contact ball 15 is provided with a silicone pad layer, and the bottom end of each contact ball 15 is fixedly connected with a fixing rod 16, each fixing rod 16 is located on the outside of the heating base 4, and each fixing rod 16 is fixedly installed on the inner wall of the bottom end of the heating box 1, wherein the multiple contact balls 15 and the fixing rods 16 are provided, while realizing the effective limiting auxiliary support for the placement position of the dissolution cup 3, it can also realize the limiting effect on the movable position of the lower side of the limiting box plate 2, and the silicone pad layer (this is the existing medium and high temperature resistant silicone material) provided on the outer wall of each contact ball 15 can effectively ensure the anti-slip and flexible contact effect between the contact ball 15 and the outer wall of the dissolution cup 3.

[0034] The implementation principle of this embodiment is: when in use, while adding the dissolving liquid and nano drug preparation into the two dissolution cups 3 respectively, the auxiliary components outside the heating box 1 (not shown in the drawings) are used in conjunction with the heating base 4 at the bottom of the two dissolution cups 3 to achieve effective dissolution of the preparation in the dissolution cups 3. The auxiliary components provided are summarized as the prior art with the same structure and principle as the reference document publication number: CN215180107U, and include "support plate, drive motor, rotating shaft, stirring paddle, cover plate, filter pressure plate, through hole, rotating bearing, adsorption magnet, spring, scraper rod". The specific working process of cooperating with the two multi-section electric push rods 14 can refer to the content in the reference document, and no further elaboration is made here.

[0035] When a round of dissolution is completed, the motor 10 can be started to drive the rotating shaft 9 and the gear 8 to rotate. At the same time, the meshing action of the gear 8 and the tooth groove ring 7 on the outer wall of the top end of the I-shaped rotating rod 6 is used to indirectly make the I-shaped rotating rod 6 drive the screw 5 to rotate. At this time, the threaded connection state between the limit box plate 2 and the screw 5, and the sliding sleeve state between the limit box plate 2 and the inner wall of the heating box 1 are used to make the limit box plate 2 move vertically downward, and the cup bodies of the two dissolution cups 3 are passively exposed. At the same time, two multi-section electric push rods 14 are required to make the auxiliary components away from the upper side of the dissolution cup 3. After that, the cup ear block 12 can be used to take down the dissolution cup 3, so as to realize the extraction of the dissolved preparation and facilitate the dissolution of the subsequent preparation.

[0036] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A dissolution device for analyzing nanoformulations, comprising a heating box (1), characterized in that: The inner wall of the top end of the heating box (1) is slidably sleeved with a limit box plate (2), and legs are fixedly installed at the four corners of the bottom of the heating box (1), the inner cavities on both sides of the limit box plate (2) are penetrated with round holes, and the two sides of the limit box plate (2) are slidably sleeved with dissolution cups (3) through the round holes, the outer wall of the bottom end of each dissolution cup (3) contacts a heating base (4), and the heating base (4) is arranged on the inner wall of the bottom end of the heating box (1), and the central inner cavity of the limit box plate (2) is penetrated with a screw (5), and the screw (5) is located between the two dissolution cups ( 3), and the bottom of the screw rod (5) is fixedly connected to an I-shaped rotating rod (6), the I-shaped rotating rod (6) is slidably sleeved through the center position of the bottom end of the heating box (1), and the outer wall of the top end of the I-shaped rotating rod (6) is circumferentially provided with a toothed groove ring (7), one side end of the toothed groove ring (7) is meshed with a gear (8), the bottom of the gear (8) is fixedly connected to a rotating shaft (9), the rotating shaft (9) is movably sleeved through the bottom end of the heating box (1), and the bottom of the rotating shaft (9) is connected to a motor (10), and the motor (10) is fixedly installed at the bottom of the heating box (1).

2. A dissolution device for nanoformulation analysis according to claim 1, characterized in that: Each of the heating bases (4) comprises a metal seat fixedly mounted on the inner wall of the bottom end of the heating box (1), and an electric heating wire is arranged inside the metal seat.

3. A dissolution device for nanoformulation analysis according to claim 1, characterized in that: A limiting plate (11) is fixedly mounted on the top of the screw rod (5); the limiting plate (11) is located on the top of the limiting box plate (2), and the limiting plate (11) is not connected to the limiting box plate (2).

4. A dissolution device for nanoformulation analysis according to claim 1, characterized in that: The outer walls of the two dissolution cups (3) on the sides facing away from each other are fixedly connected with cup ear blocks (12), and the two cup ear blocks (12) are in contact with the top position of the limiting box plate (2).

5. A dissolution device for nanoformulation analysis according to claim 1, characterized in that: The middle parts of the outer walls on both sides of the bottom end of the heating box (1) are fixedly connected with mounting blocks (13), the tops of the two mounting blocks (13) are fixedly mounted with multi-section electric push rods (14), and the driving ends of the tops of the two multi-section electric push rods (14) are jointly provided with auxiliary components.

6. A dissolution device for nanoformulation analysis according to claim 1, characterized in that: The arc-shaped positions of the outer walls at the bottom ends of the two dissolution cups (3) are in circular uniform contact with four contact balls (15), the outer wall of each contact ball (15) is provided with a silicone cushion layer, and the bottom end of each contact ball (15) is fixedly connected to a fixing rod (16), each fixing rod (16) is located on the outside of the heating base (4), and each fixing rod (16) is fixedly installed on the inner wall of the bottom end of the heating box (1).

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