High-throughput diaphragm holder

Abstract

The utility model provides a high-flux membrane holder, which is characterized in that a filter is arranged on an extraction disc base, an extraction membrane is arranged on the filter, a sealing compression ring is arranged on the outer side of the top of the extraction membrane, and a sealing ring is arranged between the outer side of the top surface of the sealing compression ring and the extraction disc base. An inner ring and an outer ring which are integrally connected are arranged on the lower portion of the open type diaphragm pressing cup, the outer ring of the diaphragm pressing cup is fixedly connected with the outer side of the extraction disc base, and the bottom side of the inner ring of the diaphragm pressing cup is tightly pressed on the top face of the sealing ring and the top face of the sealing pressing ring to form sealing. Due to the fact that the extraction disc base and the sealing pressing ring only need to fix a very small outermost annular area of the extraction membrane, the remaining areas of the extraction membrane are all effective extraction areas, and under the condition that the size of the extraction membrane is fixed, the extraction disc can adapt to large-size and high-flux extraction to a greater extent.

Description

Technical Field

[0001] The utility model relates to a high-throughput membrane holder, in particular to a high-throughput membrane holder for solid phase extraction. Background Art

[0002] Solid phase extraction is a common pretreatment method for trace analysis of pollutants in liquid samples, and membrane extraction is particularly suitable for processing large-volume liquid samples.

[0003] At present, the holders available for membrane extraction on the market mainly include glass sand core extraction devices, disposable filter head holders, and membrane holders with replaceable membranes. However, all of the above have various problems:

[0004] Glass sand cores are large in size, inconvenient to operate, the glass material is fragile, and not easy to clean;

[0005] The disposable filter head holder has a diaphragm sealed in a small chamber. The liquid inlet and outlet are in the form of Luer heads with small diameters. The liquid inlet and outlet speeds are limited, thus limiting the speed at which the sample passes through the membrane. The liquid outlet is in the middle of the diaphragm. When negative pressure acts on the liquid outlet, the vacuum formed under the diaphragm is different. The closer to the liquid outlet, the greater the vacuum. The sample tends to pass through the middle of the membrane, resulting in uneven sample permeability on the membrane. The structure of the liquid inlet and outlet means that this holder can only transmit samples through pipelines, which can easily cause pipeline blockage when handling dirty samples. In addition, the disposable filter head holder cannot replace the membrane and cannot be reused, resulting in high cost of use.

[0006] Although some replaceable membrane holders have solved the problem of replaceable membranes and reusable holders, their structure is still similar to that of disposable filter holders, and there are still problems such as uneven sample flow and dirty samples clogging the pipeline, and strict sealing cannot be achieved. The entry of air leads to a decrease in the extraction rate during the extraction process and the consistency of the recovery rate. Utility Model Content

[0007] In order to solve the above disadvantages of common membrane holders, the utility model provides a high-throughput membrane holder, making it more suitable for extraction.

[0008] The technical solution adopted by the utility model is:

[0009] A high-throughput membrane clamp, characterized in that a filter is placed on the base of an extraction disk, an extraction membrane is placed on the filter, a sealing pressure ring is placed on the outer side of the top of the extraction membrane, a sealing ring is provided between the outer side of the top surface of the sealing pressure ring and the base of the extraction disk, an inner ring and an outer ring connected as one piece are provided at the lower part of an open-type membrane pressure cup, the outer ring of the membrane pressure cup is fixedly connected to the outer side of the base of the extraction disk, and the bottom side of the inner ring of the membrane pressure cup is pressed against the sealing ring and the top surface of the sealing pressure ring to form a seal.

[0010] In the high-flux membrane holder, a groove is provided between the outer side of the top surface of the sealing pressure ring and the base of the extraction disk, and the sealing ring is embedded in the groove.

[0011] In the high-throughput membrane holder, the outer ring of the membrane pressure cup is connected to the outer side of the extraction plate base by threads.

[0012] The high-throughput membrane holder, wherein the extraction disk base is cylindrical, and a radial support frame is formed inside for placing the filter disk, and the support frame has grooves to form multiple vacuum diversion chambers, and the grooves are connected to the conical joint at the bottom of the extraction disk base.

[0013] The high-throughput membrane holder, wherein the bottom surface of the groove is an inclined surface.

[0014] In the high-throughput membrane holder, the outer peripheral side of the bottom of the extraction disk base is provided with straight knurling.

[0015] The high-throughput membrane holder is provided with a first annular groove and a second annular groove inside the extraction disk base, for embedding and fixing the filter sheet and the extraction membrane respectively.

[0016] The high-throughput membrane holder includes a filter aid layer added above the extraction membrane, and a stainless steel filter mesh placed above the filter aid layer.

[0017] Since the extraction disk base and the sealing pressure ring only need to fix a very small outer annular area of ​​the extraction membrane, the remaining area of ​​the extraction membrane is the effective extraction area. Under the condition of a certain size of the extraction membrane, the utility model can adapt to large-volume and high-throughput extraction to a greater extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a sectional view of the overall structure of the utility model.

[0019] Figure 2 It is a schematic diagram of the three-dimensional structure of the extraction disk base.

[0020] Figure 3 It is a schematic diagram of the utility model used in conjunction with a stainless steel filter screen and a filter aid layer.

[0021] Explanation of the reference numerals: 1-extraction disc base, 101-support frame, 102-groove, 103-external thread, 104-straight knurling, 105-first annular groove, 106-second annular groove, 107-tapered joint, 2-filter plate, 3-extraction membrane, 4-sealing pressure ring, 401-groove, 5-diaphragm pressure cup, 6-O-ring, 7-stainless steel filter screen, 8-filter aid layer. DETAILED DESCRIPTION

[0022] like Figure 1 , Figure 2 As shown, the utility model provides a high-throughput membrane clamp, wherein a filter plate 2 is placed on an extraction disk base 1, an extraction membrane 3 is placed on the filter plate 2, a sealing pressure ring 4 is placed on the outer side of the top of the extraction membrane 3, a groove 401 is provided between the outer side of the top surface of the sealing pressure ring 4 and the extraction disk base 1, and an O-ring 6 is embedded in the groove 401; a coarse thread external thread 103 is provided on the outer side of the extraction disk base 1, and an inner ring and an outer ring connected as one body are provided at the lower part of an open-type membrane pressure cup 5, and the outer ring is provided with a coarse thread internal thread, so as to be threadedly connected to the outer side of the extraction disk base 1, and the bottom side of the inner ring of the membrane pressure cup 5 is pressed tightly against the O-ring 6 and the top surface of the sealing pressure ring 4 to form a seal.

[0023] like Figure 1 , Figure 2 As shown, the extraction disk base 1 is cylindrical as a whole, and a radial support frame 101 is formed inside to facilitate the placement of the filter plate 2. A groove 102 is formed inside the support frame 101, and the bottom surface of the groove 102 is an inclined surface, which is conducive to the downward discharge of the sample and is connected to the conical joint 107 at the bottom; a straight knurling 104 is provided on the outer peripheral side of the bottom of the extraction disk base 1, which is convenient for people to hold and rotate and apply force; a first annular groove 105 and a second annular groove 106 are also provided inside the extraction disk base 1, for the filter plate 2 and the extraction membrane 3 to be embedded and fixed respectively;

[0024] The bottom surface of the groove 102 is an inclined surface, which is conducive to the downward discharge of the sample, reduces sample residues, and improves the recovery rate.

[0025] The support frame 101 and the groove 102 form a plurality of vacuum diversion chambers, which can disperse the effective area of ​​the negative pressure on the extraction membrane and ensure that the sample can pass through the extraction membrane evenly.

[0026] The O-ring 6 is installed between the sealing pressure ring 4 and the extraction disk base 1 to ensure the smooth formation of negative pressure below the extraction membrane and prevent the extraction efficiency from being reduced due to sealing problems.

[0027] The groove 401 provided on the sealing pressure ring 4 can facilitate the use of tools to take out the sealing pressure ring 4 when replacing the extraction membrane 3 .

[0028] The extraction disk base 1 and the sealing pressure ring 4 only need to fix a very small outer annular area of ​​the extraction membrane 3, and the remaining area of ​​the extraction membrane 3 is the effective extraction area. When the size of the extraction membrane 3 is constant, the utility model can adapt to large-volume and high-throughput extraction to a greater extent.

[0029] After sealing, the dye is poured into the membrane pressing cup 5, and the dye is allowed to flow through the extraction membrane 3 under the action of negative pressure. After completion, the extraction membrane 3 is removed, and the dye only remains on the effective extraction area and does not diffuse into the annular area.

[0030] When the sample to be extracted is contained in the membrane pressing cup 5, the device can ensure that the sample passes through the extraction membrane 3 smoothly to complete the extraction process and flows into the next collection structure through the conical joint 107. The inner bottom side of the membrane pressing cup 5 has an inclined surface, which can prevent sample residue and reduce the generation of dead volume.

[0031] Before pouring the sample, first place the filter 2 in the first annular groove 105 on the extraction disk base 1, then place the extraction membrane 3 in the second annular groove 106, then put the sealing pressure ring 4 into the extraction disk base 1, and place the O-ring 6 in the groove 401 formed by the sealing pressure ring 4 and the extraction disk base 1, and finally screw the membrane pressure cup 5 onto the extraction disk base 1 until the O-ring 6 is compressed to play a sealing role.

[0032] When negative pressure is applied at the conical joint 7, a vacuum is formed in the vacuum chamber. A certain solvent is selected to activate the extraction membrane 3, and then the sample is allowed to pass through the extraction membrane 3 evenly. The substance of interest is retained on the extraction membrane 3, and other components become waste liquid and enter the waste liquid bucket. After the sample loading is completed, a suitable eluent is selected to elute the substances retained on the extraction membrane 3 and collect them in a container.

[0033] When the extraction membrane 3 needs to be replaced, first unscrew the diaphragm pressure cup 5, then use a tool to take out the sealing pressure ring 4 and the O-ring 6 along the groove 401 of the sealing pressure ring 4, replace the new extraction membrane 3, then reinstall the sealing pressure ring 4 and the O-ring 6, and tighten the diaphragm pressure cup 5.

[0034] like Figure 3 As shown, when the sample is a dirty sample, in order to improve the use efficiency of the extraction membrane 3, a filter aid layer 8 (including but not limited to diatomaceous earth, quartz sand, etc.) can be added above the extraction membrane 3, and a stainless steel filter mesh 7 can be placed above the filter aid layer 8 to prevent the filter aid layer 8 from splashing during the sample landing process, and it can also play a role in preliminary filtering of large particle impurities in the sample.

[0035] The advantages of the utility model include:

[0036] 1. Reusable and economical;

[0037] 2. Simple structure and easy disassembly;

[0038] 3. The vacuum diversion chamber disperses the vacuum, making the suction force more uniform;

[0039] 4. Double-layer sealing of sealing ring and sealing ring prevents air from entering the diaphragm and improves the consistency of experimental results;

[0040] 5. The open design can directly extract dirty water samples. For samples with high particle content, a certain amount of filter aid can be loaded on the membrane to help the water sample pass smoothly.

Claims

1. A high-throughput membrane holder, characterized in that: A filter is placed on the base of the extraction disk, an extraction membrane is placed on the filter, a sealing pressure ring is placed on the outer side of the top of the extraction membrane, a sealing ring is provided between the outer side of the top surface of the sealing pressure ring and the base of the extraction disk, an inner ring and an outer ring connected as one piece are provided at the lower part of the open diaphragm pressure cup, the outer ring of the diaphragm pressure cup is fixedly connected to the outer side of the base of the extraction disk, and the bottom side of the inner ring of the diaphragm pressure cup is pressed against the sealing ring and the top surface of the sealing pressure ring to form a seal.

2. The high-throughput membrane holder according to claim 1, characterized in that: A groove is provided between the outer side of the top surface of the sealing pressure ring and the base of the extraction disk, and the sealing ring is embedded in the groove.

3. The high-throughput membrane holder according to claim 1, characterized in that: The outer ring of the diaphragm pressure cup is connected to the outer side of the extraction plate base by threads.

4. The high-throughput membrane holder according to claim 1, characterized in that: The extraction disc base is cylindrical, with a radial support frame formed inside for placing the filter disc. The support frame has grooves to form a plurality of vacuum diversion chambers, and the grooves are connected to the conical joint at the bottom of the extraction disc base.

5. The high-throughput membrane holder according to claim 4, characterized in that: The bottom surface of the groove is an inclined surface.

6. The high-throughput membrane holder according to claim 1, characterized in that: The outer peripheral side of the bottom of the extraction plate base is provided with straight knurling.

7. The high-throughput membrane holder according to claim 1, characterized in that: A first annular groove and a second annular groove are arranged inside the extraction disc base, for respectively embedding and fixing the filter sheet and the extraction membrane.

8. The high-throughput membrane holder according to claim 1, characterized in that: A filter aid layer is added above the extraction membrane, and a stainless steel filter mesh is placed above the filter aid layer.

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