Medicine crystallization device

Abstract

The utility model discloses a medicine crystallization device, which relates to the field of pharmaceutical devices, and comprises a crystallization kettle body, a feed port and a discharge port, the crystallization kettle body comprises a supporting part and a movable part connected with the supporting part, the movable part is arranged at the lower end of the supporting part, and the supporting part and the movable part are communicated to jointly form a containing cavity. The discharge port is formed in the movable part, and a discharge valve is arranged on the discharge port; a supporting mechanism is connected to the supporting part and is used for supporting the crystallization kettle body; wherein the supporting part is made of rigid materials, the movable part is made of flexible materials, a motor is connected to the flexible part, and when the motor operates, the flexible part can shake. According to the utility model, the crystallization kettle body is arranged to be a combination of the rigid supporting part and the flexible movable part, and vibration is applied to the flexible part, so that the aims of dredging the discharge hole and accelerating discharge are fulfilled.

Description

Technical Field

[0001] The utility model relates to the field of pharmaceutical devices, in particular to a drug crystallization device. Background Art

[0002] A drug crystallizer is a device used to produce drug crystals. In the pharmaceutical industry, drugs are usually present in the form of crystals because crystals have higher purity and stability, which is crucial for the efficacy and safety of drugs. The drug crystallizer controls parameters such as temperature, pressure, concentration of solvents and solutes to gradually form crystals from drug molecules in the drug solution. These crystals can be further purified and used in the next step of the pharmaceutical process, such as preparing tablets, capsules or injections.

[0003] In order to facilitate the discharge of crystals, the discharge port of the drug crystallization device is generally set at the bottom of the device. During the drug crystallization process, crystals will be deposited near the discharge port, forming a blockage. At the same time, these small crystals may fuse with each other during the accumulation process and gradually accumulate into crystals with larger particles, increasing the discharge rate of drug crystals. Some drugs may have high viscosity or adhesion, which makes it easy for the crystalline material to adhere to and clog the discharge port.

[0004] In view of this, this application is hereby filed. Utility Model Content

[0005] The utility model aims to provide a drug crystallization device, which solves the problem that the discharge port of the drug crystallization device in the prior art is easily blocked by configuring the crystallization kettle body to be a combination of a rigid supporting part and a flexible movable part, applying vibration to the flexible part, so that the crystals vibrate and interact with each other.

[0006] The embodiment of the utility model is realized by the following technical scheme: a drug crystallization device comprises a crystallization kettle body and a feed port and a discharge port arranged on the crystallization kettle body, the crystallization kettle body comprises a support part and a movable part connected to the support part, the movable part is arranged at the lower end of the support part, the support part and the movable part are connected to form a accommodating chamber, the discharge port is arranged on the movable part, and a discharge valve is arranged on the discharge port; a support mechanism is connected to the support part, and the support mechanism is used to support the crystallization kettle body;

[0007] The supporting part is made of a rigid material, the movable part is made of a flexible material, and a motor is connected to the flexible part. When the motor is running, the flexible part can vibrate.

[0008] Preferably, the cross section of the movable part is "V"-shaped, and the discharge port is arranged at the lowest point of the movable part.

[0009] Preferably, the movable part is a downwardly convex arc surface structure, and the discharge port is arranged at the lowest point of the movable part.

[0010] Preferably, a plurality of crystal support plate mechanisms are arranged in the accommodating chamber, the crystal support plate mechanisms include elastic rods and panels, one end of the elastic rods is connected to the cavity wall of the accommodating chamber, and the other end is connected to the panel, and the panel is arranged to be tilted downward.

[0011] Preferably, there are more than two crystal support plate mechanisms, and at least two crystal support plate mechanisms are arranged up and down, and the crystal on the upper crystal support plate mechanism can fall onto the panel of the lower crystal support plate mechanism.

[0012] Preferably, a water outlet is provided on the crystallization kettle body, and a water outlet valve is provided on the water outlet.

[0013] Preferably, the crystallization kettle body is an upper open structure, an end cover is movably provided at the end of the support portion, a vent is provided on the end cover, and a vent valve is provided on the vent.

[0014] Preferably, a pressure detection device is also provided on the end cover.

[0015] Preferably, the supporting mechanism comprises a first supporting foot and a second supporting foot which are symmetrically arranged, and the first supporting foot and the second supporting foot are respectively connected to the supporting part.

[0016] Preferably, the first supporting foot comprises a trapezoidal foot and a supporting rod, the supporting rod comprises a radial portion and an axial portion connected to each other, the trapezoidal foot is arranged at the end of the axial portion, and the radial portion is connected to the supporting portion.

[0017] Compared with the prior art, the embodiments of the present invention have the following advantages and beneficial effects:

[0018] 1. A pharmaceutical crystallization device provided by an embodiment of the utility model, wherein a crystallization kettle body is configured as a combination of a support portion and a movable portion, the support portion and the movable portion together form a accommodating chamber, and the accommodating chamber is used to crystallize the liquid, the movable portion is configured to be made of a flexible material and is arranged at the lower end of the support portion, and the discharge port is arranged on the movable portion, that is, when the crystallization is completed, the crystal will be discharged from the lower end of the crystallization kettle body. Since the movable portion is made of a flexible material, when the flexible portion vibrates, the crystal has peristalsis in the accommodating chamber of the flexible section, which can serve the purpose of unblocking the discharge port or improving the discharge efficiency.

[0019] The supporting part is made of rigid material, and the movable part can be connected to the engine. When the discharge port is blocked, the movable part can be shaken within the supporting range of the supporting part to improve the discharge efficiency. Since a supporting mechanism is provided on the supporting part, the supporting mechanism is used to support the entire device. When the movable part shakes, it can ensure that other components such as the supporting part remain balanced and stable, thereby ensuring the stability of the entire device.

[0020] 2. The embodiment of the utility model provides two kinds of movable part structures, namely a structure with a "V"-shaped cross-section and an arc surface structure that is convex downward as a whole. Both structures have a lowest point. The crystalline medicine of this structure will be guided to the discharge port by the "V"-shaped slope when flowing. At the same time, the pressure of the medicine crystal on the movable part will be decomposed by the "V"-shaped slope into a pressure perpendicular to the slope, which reduces the interaction force between the crystals in the discharge direction, helps to ensure the fluffiness of the medicine crystals, and reduces the probability of clogging of the discharge port.

[0021] 3. Setting up several crystal support plate mechanisms can share part of the crystal support and improve the fluffiness of the crystals in the containing chamber. Since the panel is tilted, the drug crystals will slowly fall on the panel, causing a slow accumulation process of the drug crystals at the bottom of the containing chamber. Even if they fall in batches, they will be scattered due to the impact of the height difference. The elastic rod will expand the shaking amplitude of the panel to ensure that all the drug crystals on the panel are finally discharged.

[0022] In general, the pharmaceutical crystallization device provided by the embodiment of the utility model configures the crystallization kettle body into a combination of a rigid support portion and a flexible movable portion, and applies vibration to the flexible portion to achieve the purpose of unblocking the discharge port and accelerating the discharge. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the utility model and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 A schematic diagram of the structure of a drug crystallization device provided in Example 1 of the utility model;

[0025] Figure 2 This is a schematic diagram of the structure of the drug crystallization device provided in Example 2 of the utility model.

[0026] Marks and corresponding parts names in the attached drawings:

[0027] 1-feed port, 2-discharge port, 3-support portion, 4-movable portion, 6-crystal support plate mechanism, 7-elastic rod, 8-panel, 9-water outlet, 10-end cover, 11-vent, 12-pressure detection device, 13-first supporting foot, 14-second supporting foot, 15-trapezoidal foot, 16-support rod, 17-radial portion, 18-axial portion. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. The components of the embodiment of the utility model described and shown in the drawings here can be arranged and designed in various different configurations.

[0029] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the present invention to be protected, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0031] In the description of the present invention, it should be noted that the terms "first", "second", "third", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0032] Example

[0033] Example 1: Figure 1As shown, an embodiment of the utility model provides a drug crystallization device, including a crystallization kettle body and a feed port 1 and a discharge port 2 arranged on the crystallization kettle body, the crystallization kettle body provides a crystallization reaction space, the feed port 1 is used to transport the liquid to be crystallized into the crystallization kettle body, and the discharge port 2 is used to discharge the crystals in the crystallization kettle body, wherein the feed port 1 can be directly arranged on the crystallization kettle body, and can also be indirectly arranged on the crystallization kettle body, for example, an end cover 10 can be arranged on the crystallization kettle body, and the feed port 1 is arranged on the end cover 10, and the end cover 10 is movably connected to the crystallization kettle body, so that during the crystallization reaction, the end cover 10 can form a closed space with the crystallization kettle body to prevent the drug from reacting with external substances and causing the drug to fail, and the movably connected end cover 10 can facilitate subsequent cleaning. The crystallization kettle body includes a support part 3 and a movable part 4 connected to the support part 3, the movable part 4 is arranged at the lower end of the support part 3, the support part 3 and the movable part 4 are connected to form a accommodating chamber, that is, the crystallization kettle body of the utility model is spliced ​​together by the support part 3 and the movable part 4, the support part 3 and the movable part 4 are sealed to ensure the airtightness of the accommodating chamber, the discharge port 2 is arranged on the movable part 4, and a discharge valve is arranged on the discharge port 2, the discharge valve is used to control the closure of the discharge port 2, so that it maintains airtightness during the crystallization reaction, and the crystal can be discharged smoothly after the crystallization reaction; a supporting mechanism is connected to the support part 3, the supporting mechanism is used to support the crystallization kettle body, the supporting mechanism is connected to the support part 3, so that the supporting mechanism stably supports the entire device, the connection between the supporting mechanism and the support part 3 can be an integrated setting, welding, bonding, etc., there is no restriction here, as long as sufficient support stability can be achieved.

[0034] Among them, the support part 3 is made of a rigid material, which can be stainless steel or other materials, which is not limited here. The movable part 4 is made of a flexible material, which can be rubber or other materials, which is not limited here. A motor is connected to the flexible part, and when the motor is running, the flexible part can shake. Specifically, the support part 3 supports the flexible part so that the flexible part can shake within the range of the support part 3. During the shaking of the flexible part, the support part 3 can maintain relative stability under the support of the support mechanism. When the motor is running, it drives the flexible part to shake, which can loosen the drug crystals in the accommodating cavity, dredge the discharge port 2, and improve the discharge efficiency. It should be noted that the shaking direction here is mainly up and down shaking, and can also include left and right shaking, as long as it can achieve the purpose of promoting the dredging of the discharge port.

[0035] In order to further improve the discharge efficiency, the cross-section of the movable part 4 can be made into a "V" shape, and then the discharge port 2 can be set at the lowest point of the movable part 4. Specifically, the crystalline drug will be guided to the discharge port 2 by the "V"-shaped slope when flowing, and at the same time, the pressure of the drug crystals on the movable part 4 will be decomposed by the "V"-shaped slope into a layer perpendicular to the slope, thereby reducing the interaction force between the crystals in the discharge direction, helping to ensure the fluffiness of the drug crystals and reducing the probability of blockage of the discharge port 2.

[0036] Furthermore, a plurality of crystal support plate mechanisms 6 are arranged in the accommodating chamber, and the crystal support plate mechanisms 6 include an elastic rod 7 and a panel 8, one end of the elastic rod 7 is connected to the cavity wall of the accommodating chamber, and the other end is connected to the panel 8, and the panel 8 is arranged to be tilted downward. The tilted crystal support plate mechanism 6 can share the support for part of the drug crystals, effectively preventing the crystals from being deposited too much at the bottom of the accommodating chamber, and reducing the risk of blockage of the discharge port 2. At the same time, the tilted panel 8 can effectively guide the crystallized material to flow toward the discharge port 2, further reducing the possibility of the crystallized material accumulating inside the accommodating chamber. It is important that since the panel 8 is tilted, the drug crystals will slowly fall on the panel 8, so that the drug crystals at the bottom of the accommodating chamber have a slow accumulation process. Even if they fall in batches, they will be scattered due to the impact of the height difference. The elastic rod 7 will expand the shaking amplitude of the panel 8 to ensure that all the drug crystals on the panel 8 are finally discharged. Exemplarily, the elastic rod 7 can also be connected to a motor. When the crystals near the discharge port 2 are almost discharged, the motor can shake the elastic rod 7, so that the drug crystals on the corresponding panel 8 fall to the discharge port 2 and continue to discharge. This gradual discharge structure can reduce the possibility of blockage of the discharge port 2.

[0037] It should be noted that the number of crystal support plate mechanisms 6 is not limited here. Generally speaking, the larger the number, the more fluffy the drug crystals in the accommodating chamber are, and the better the anti-blocking effect is. As a preferred embodiment of the utility model, there are more than two crystal support plate mechanisms 6, and at least two crystal support plate mechanisms 6 are arranged up and down, and the crystals on the upper crystal support plate mechanism 6 can fall onto the panel 8 of the lower crystal support plate mechanism 6. The crystals on the upper crystal support plate mechanism 6 can fall freely onto the panel 8 of the lower crystal support plate mechanism 6, which helps to maintain the continuous flow of crystals and reduces the possibility of accumulation of crystalline materials inside the device. Through this multi-stage support and continuous discharge design, the stability of the crystallization process can be effectively maintained, and the risk of deposition of crystalline materials near the discharge port 2 is reduced. For example, as Figure 1 As shown, four crystal support plate mechanisms 6 can be provided, such as Figure 2As shown, three crystal support plate mechanisms 6 can also be provided, and the relative position between each crystal support plate mechanism 6 can be set according to the actual situation, and there is no restriction here, as long as it can achieve the purpose of at least meeting the vertical arrangement between the crystal support plate mechanisms 6, and the crystal on the upper crystal support plate mechanism 6 can fall onto the panel 8 of the lower crystal support plate mechanism 6. Preferably, each crystal support plate mechanism 6 is provided on the support part 3. Of course, part of the crystal support plate mechanism 6 can also be provided on the movable part 4, and there is no restriction here. Specifically, Figure 1-2 shown.

[0038] In an embodiment of the utility model, a water outlet 9 is provided on the crystallization kettle body, and a water outlet valve is provided on the water outlet 9. The water outlet valve can control the opening and closing of the water outlet 9, and discharge the excess liquid in the accommodating chamber at an appropriate time. The concentration of the solution during the crystallization process can be controlled, which helps to promote or inhibit the formation of crystals, thereby regulating the rate and quality of crystallization. Preferably, the crystallization kettle body is an upper end opening structure, and an end cap 10 is movably provided at the end of the support portion 3, and a vent 11 is provided on the end cap 10, and a vent valve is provided on the vent 11. Specifically, the crystallization kettle body adopts an upper end opening structure, which is convenient for cleaning and maintaining the crystallization kettle. The provision of the end cap 10 helps to close the crystallization kettle to prevent the solution or crystallized material from overflowing, and can also keep the temperature and pressure inside the crystallization kettle stable. The end cap 10 is provided with a vent 11 and a vent valve, which allows the release of generated gas or the adjustment of the air pressure inside the crystallization kettle during the crystallization process. The air pressure difference can be used for feeding and draining. The vent 11 and the vent valve can effectively prevent the internal pressure of the crystallization kettle from being too high or gas accumulation, thereby ensuring the safety and stability of the crystallization process. In order to more accurately control the pressure in the accommodating chamber, a pressure detection device 12 can be provided on the end cap 10. The pressure detection device 12 can be a pressure sensor or a pressure gauge and other equipment for real-time monitoring of the pressure changes inside the crystallization kettle. When the pressure reaches the set threshold, the operator can adjust the operating parameters of the crystallization device in time, such as temperature, pressure or solution flow rate, to ensure the safety and stability of the crystallization process.

[0039] In order to improve the stability of the entire crystallization device, the support mechanism is configured to include a symmetrically arranged first support leg 13 and a second support leg 14, and the first support leg 13 and the second support leg 14 are respectively connected to the support portion 3. Through the symmetrically arranged first support leg 13 and the second support leg 14, the weight and force distribution of the crystallization device can be balanced, so that the crystallization device is more firmly supported on the ground or other supporting platforms, which helps to reduce the shaking and vibration of the crystallization device during the crystallization process, thereby improving the stability and reliability of the crystallization process. Exemplarily, the first support leg 13 includes a trapezoidal foot 15 and a support rod 16, and the support rod 16 includes a radial portion 17 and an axial portion 18 connected to each other. The trapezoidal foot 15 is arranged at the end of the axial portion 18, and the connection between the radial portion 17 and the support portion 3 can be an integral arrangement or can be connected by bonding, clamping, etc. The radial portion 17 and the axial portion 18 are connected to each other and together constitute the whole of the support rod 16. The trapezoidal foot 15 is arranged at the end of the axial portion 18, which is the lower support part of the support mechanism, and is used to stabilize the crystallization device and disperse the weight and force generated during the crystallization of the drug. At the same time, the trapezoidal structure can increase the support area and improve the support stability.

[0040] Example 2: Figure 2 As shown, the difference from Example 1 is that the active part 4 of the crystallization device is a downwardly convex arc surface structure, and the discharge port 2 is arranged at the lowest point of the active part 4. The arc surface structure also has a guiding effect and a pressure dispersing effect on the drug crystals, and can also make the crystallized material flow more smoothly in the crystallization device.

[0041] The above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. For those skilled in the art, the utility model can have various modifications and changes. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the utility model should be included in the protection scope of the utility model. It should be noted that the structures or components illustrated in the drawings are not necessarily drawn to scale, and the utility model omits the description of known components and processing technologies and processes to avoid unnecessary limitations on the utility model.

Claims

1. A drug crystallization device, comprising a crystallization kettle body and a feed inlet (1) and a discharge outlet (2) arranged on the crystallization kettle body, characterized in that: The crystallization kettle body comprises a support portion (3) and a movable portion (4) connected to the support portion (3), the movable portion (4) being arranged at the lower end of the support portion (3), the support portion (3) and the movable portion (4) being connected to form a containing chamber, the discharge port (2) being arranged on the movable portion (4), and a discharge valve being arranged on the discharge port (2); a support mechanism being connected to the support portion (3), and the support mechanism being used to support the crystallization kettle body; The support portion (3) is made of a rigid material, the movable portion (4) is made of a flexible material, a motor is connected to the movable portion (4), and when the motor is in operation, the movable portion (4) can vibrate; A plurality of crystal support plate mechanisms (6) are arranged in the accommodating chamber, and the crystal support plate mechanisms (6) comprise elastic rods (7) and a panel (8), one end of the elastic rods (7) is connected to the cavity wall of the accommodating chamber, and the other end is connected to the panel (8), and the panel (8) is arranged to be tilted downward.

2. A drug crystallization device according to claim 1, characterized in that: The cross section of the movable part (4) is V-shaped, and the discharge port (2) is arranged at the lowest point of the movable part (4).

3. A drug crystallization device according to claim 1, characterized in that: The movable portion (4) is a downwardly convex curved surface structure, and the discharge port (2) is arranged at the lowest point of the movable portion (4).

4. A drug crystallization device according to claim 1, characterized in that: The crystal support plate mechanisms (6) are provided with more than two, and at least two crystal support plate mechanisms (6) are arranged up and down, and the crystal on the upper crystal support plate mechanism (6) can fall onto the panel (8) of the lower crystal support plate mechanism (6).

5. A drug crystallization device according to claim 1, characterized in that: The crystallization kettle body is provided with a water outlet (9), and the water outlet (9) is provided with a water outlet valve.

6. A drug crystallization device according to claim 1, characterized in that: The crystallization kettle body is an open structure at the top, an end cover (10) is movably provided at the end of the support portion (3), a vent (11) is provided on the end cover (10), and a vent valve is provided on the vent (11).

7. A drug crystallization device according to claim 6, characterized in that: The end cover (10) is also provided with a pressure detection device (12).

8. A drug crystallization device according to claim 1, characterized in that: The support mechanism comprises a first support foot (13) and a second support foot (14) which are symmetrically arranged, and the first support foot (13) and the second support foot (14) are respectively connected to the support portion (3).

9. A drug crystallization device according to claim 8, characterized in that: The first supporting foot (13) comprises a trapezoidal foot (15) and a supporting rod (16), the supporting rod (16) comprising a radial portion (17) and an axial portion (18) which are connected to each other, the trapezoidal foot (15) being arranged at the end of the axial portion (18), and the radial portion (17) being connected to the supporting portion (3).

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