Stirring device for preparing dextran

Abstract

The utility model relates to the technical field of pharmaceutical devices, and provides a stirring device for preparing dextran, which comprises a reaction box, a feeding pipe and a discharging pipe, the feeding pipe and the discharging pipe are fixedly communicated on the reaction box, and stirring blades are arranged in the reaction box. The local concentration gradient caused by non-uniform mixing of solutions in the reaction box can be effectively reduced through the mixing assembly, the stirring uniformity of the solutions can be improved by adding a small amount of raw materials for multiple times through the feeding mechanism during stirring, and then it can be ensured that the raw materials added every time are fully dissolved and mixed; the problem of non-uniform mixing possibly caused by adding all the raw materials at one time is avoided; according to the utility model, the stirring-expanding assembly is designed, and when the stirring blades move downwards and rotate to the bottom of the reaction box, the stirring-expanding assembly can enable the stirring-expanding blades to expand the stirring range, so that sediments at the bottom of the reaction box are mixed with a solution at the upper part, and the concentration difference is reduced, thereby improving the uniformity of the whole reaction system.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical devices, and in particular to a stirring device for preparing dextran. Background Art

[0002] After searching, the patent with publication number CN207507457U discloses a stirring device for the production of iron dextran injection. When the existing device is used, the raw materials required for the production of iron dextran injection enter the reaction box through the first feed pipe and the second feed pipe respectively. Through the switch on the surface of the control panel, the heating plate starts to heat to the heat required for the complete reaction of the raw materials. The pH value in the reaction box is measured by the pH tester and the monitoring display shows the pH value. The switch is used to control the solenoid valves corresponding to the first feed pipe and the second feed pipe to make the pH value in the reaction box reach the corresponding environment. The switch is used to control the motor to drive the stirring shaft and the stirring blade to rotate, thereby driving the solution in the reaction box to be stirred evenly until the reaction is complete.

[0003] The rotation of the stirring blade in the above device can drive the solution in the reaction box to stir. However, due to the limited stirring range, the solution in some areas may be unevenly mixed, resulting in a local concentration gradient, affecting the reaction rate and product purity. In addition, the raw materials required for the production of iron dextran injection are added into the reaction box at one time through the first feed pipe and the second feed pipe respectively, and the stirring within the limited rotation range of the stirring blade will aggravate the problem of uneven stirring. Therefore, a stirring device for preparing dextran is needed. Utility Model Content

[0004] In view of the shortcomings of the prior art, the utility model provides a stirring device for preparing dextran, which solves the problem in the prior art that the stirring range of the stirring blade is limited, resulting in uneven mixing of solutions in some areas.

[0005] The technical scheme of the utility model is as follows: a stirring device for preparing dextran, comprising a reaction box and a feed pipe and a discharge pipe fixedly connected to the reaction box, a stirring blade is arranged inside the reaction box, a mixing component for driving the stirring blade to vertically reciprocate and stir the solution in the reaction box is arranged on the top of the reaction box, and a feeding mechanism for adding a small amount of raw materials required for production multiple times under the synchronous driving of the mixing component;

[0006] The mixing assembly includes a cylinder arranged on the top of the reaction box, the telescopic end of the cylinder is rotatably connected to a circular plate, the bottom of the circular plate is rotatably connected to a rotary rod, the outer wall of the rotary rod is threadedly connected to a driving block fixedly connected to the inner wall of the reaction box, the outer wall of the rotary rod is fixedly connected to a columnar barrel, and the stirring blade is fixed to the outer wall of the columnar barrel.

[0007] Preferably, the feeding mechanism comprises a connecting plate fixed on the circumferential surface of the circular plate, one end of the connecting plate away from the circular plate is fixedly connected to a linkage rod, and two ends of the linkage rod are symmetrically fixedly connected to two pressure plates.

[0008] Preferably, the bottoms of the two pressure plates are fixedly connected to two drug suction bags fixedly connected to the top of the reaction box, the circumferential surfaces of the top ends of the two drug suction bags are fixedly connected to one-way drug suction tubes, and the bottom ends of the two drug suction bags are fixedly connected to one-way drug discharge tubes connected to the inner cavity of the reaction box.

[0009] Preferably, an expansion stirring blade is slidably sleeved on one end of the stirring blade away from the cylindrical tube, and an expansion stirring assembly is provided inside the cylindrical tube for allowing the expansion stirring blade to cyclically contract according to the moving path of the stirring blade.

[0010] Preferably, the expansion and stirring assembly includes a communicating hole groove opened on the inner wall of the cylindrical tube, the internal sliding sleeve of the communicating hole groove is provided with a gravity plate, and the bottom of the gravity plate is fixedly connected with a buoyancy bag.

[0011] Preferably, the end surface of the expanding stirring blade is fixedly connected to a sliding plate slidably sleeved inside the stirring blade, and the outer wall of the expanding stirring blade close to one end of the stirring blade is sleeved with a spring, and the two ends of the spring are respectively fixedly connected to the sliding plate and the stirring blade.

[0012] Preferably, the interior of the communicating hole groove is filled with gas, the communicating hole groove is connected with the interior of the stirring blade, and the gas is sandwiched between the gravity plate and the sliding plate.

[0013] Preferably, the top of the reaction box is fixedly connected to a support sleeve fixedly connected to the bottom of the cylinder, and a rectangular groove for the connecting plate to slide up and down is vertically opened on the circumference of the support sleeve.

[0014] Compared with the prior art, the beneficial effects of the present invention are:

[0015] 1. The utility model designs a mixing component in conjunction with a feeding mechanism. The mixing component can effectively reduce the local concentration gradient caused by uneven mixing of solutions in the reaction box, which is helpful to improve the uniformity and stability of the reaction. While stirring, the raw materials are added in small quantities and multiple times through the feeding mechanism, and the stirring blades are moved up and down and forward and reversed, which can improve the stirring uniformity of the solution, thereby ensuring that the raw materials added each time are fully dissolved and mixed, avoiding the problem of uneven mixing that may be caused by adding all the raw materials at one time.

[0016] 2. The utility model is designed with an expansion and stirring component. When the stirring blade moves down and rotates to the bottom of the reaction box, the expansion and stirring component enables the expansion and stirring blade to expand the stirring range, mix the sediment at the bottom of the reaction box with the upper solution, reduce the concentration difference, and thus improve the uniformity of the entire reaction system. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The utility model is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0018] Figure 1 It is a schematic diagram of the three-dimensional structure proposed by the utility model;

[0019] Figure 2 It is a cross-sectional structural schematic diagram proposed by the utility model;

[0020] Figure 3 This is a schematic diagram of the cylinder structure proposed by the utility model;

[0021] Figure 4 This is a schematic diagram of the stirring blade structure proposed by the utility model;

[0022] Figure 5 This is a schematic diagram of a partial cross-sectional structure of the utility model.

[0023] In the figure: 1. reaction box; 11. feed pipe; 12. discharge pipe; 2. stirring blade; 3. mixing assembly; 31. cylinder; 32. round plate; 33. rotary rod; 34. driving block; 35. columnar tube; 4. feeding mechanism; 41. connecting plate; 42. linkage rod; 43. pressure plate; 44. drug suction bag; 45. one-way drug suction tube; 46. one-way drug discharge tube; 5. expansion stirring blade; 6. expansion stirring assembly; 61. connecting hole groove; 62. buoyancy bag; 63. gravity plate; 64. gas; 65. sliding plate; 66. spring; 7. support sleeve. DETAILED DESCRIPTION

[0024] The following will be combined with the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0025] The production of dextran is usually carried out through chemical reactions. Especially in the production of dextran iron injection, the reactants need to be mixed evenly to promote the reaction. The stirring device of dextran can ensure that the reactants are fully mixed in the reactor and improve the efficiency and rate of the reaction.

[0026] Example 1

[0027] In the existing device, the rotation of the stirring blade can drive the solution in the reaction box to stir evenly. However, due to the limited stirring range, the solution in some areas will be unevenly mixed, resulting in local concentration gradients, affecting the reaction rate and product purity. In addition, the raw materials required for the production of iron dextran injection are added into the reaction box through the first feeding pipe and the second feeding pipe at one time. Coupled with the stirring of the limited rotation range of the stirring blade, the problem of uneven stirring will be aggravated. Figure 1-Figure 5 The embodiment provides a stirring device for preparing dextran, including a reaction box 1 and a feed pipe 11 and a discharge pipe 12 fixedly connected to the reaction box 1, a stirring blade 2 is arranged inside the reaction box 1, a mixing component 3 is arranged on the top of the reaction box 1 for driving the stirring blade 2 to vertically reciprocate and stir the solution in the reaction box 1, and a feeding mechanism 4 is synchronously driven by the mixing component 3 to add small amounts of raw materials required for production multiple times.

[0028] refer to Figure 2-Figure 4 As shown, the limited stirring range will lead to uneven mixing of solutions in some areas of the reaction box 1, causing local concentration gradients, affecting the reaction rate and product purity. In order to prevent the above phenomenon from occurring, the following arrangement is made: the mixing assembly 3 includes a cylinder 31 disposed on the top of the reaction box 1, the telescopic end of the cylinder 31 is rotatably connected to a circular plate 32, the bottom of the circular plate 32 is rotatably connected to a rotary rod 33, the outer wall of the rotary rod 33 is provided with threads, the threads are threads of a specific angle, and the spacing between the threads is large. The outer wall of the rotary rod 33 is threadedly connected with a driving block 34 fixedly connected to the inner wall of the reaction box 1, and the outer wall of the rotary rod 33 is fixedly connected with a columnar tube 35, and the stirring blade 2 is fixed on the outer wall of the columnar tube 35. The cylinder 31 is started to make the telescopic end push the circular plate 32 downward, and the circular plate 32 moves downward to make the rotary rod 33 threadably connected with the driving block 34, causing the rotary rod 33 to move downward and drive the stirring blade 2 to rotate forward to uniformly stir the solution in the reaction box 1. When the cylinder 31 makes the telescopic end pull the circular plate 32 upward, the rotary rod 33 is threadably connected with the driving block 34, causing the rotary rod 33 to move upward and drive the stirring blade 2 to rotate in the opposite direction to uniformly stir the solution in the reaction box 1. Stirring the solution in the reaction box 1 by moving the stirring blade 2 up and down and rotating it forward and reversely can help reduce the local concentration gradient, and help prevent the occurrence of uneven mixing of the solution, and can generate more uniform turbulence and shear force in the reaction box 1, thereby promoting mixing and diffusion of various parts in the solution and reducing the formation of local concentration gradients.

[0029] refer to Figure 2As shown, after all the raw materials required for the production of iron dextran injection are added to the reaction box 1 at one time, the solution will be unevenly mixed due to insufficient or uneven stirring, especially for powdered raw materials, there may be lumps or agglomeration, resulting in insufficient solution mixing in some areas. In order to prevent the above phenomenon from occurring, the following settings are made. The feeding mechanism 4 includes a connecting plate 41 fixed on the circumference of the circular plate 32, and the top of the reaction box 1 is fixedly connected with a support sleeve 7 fixedly connected to the bottom of the cylinder 31. The circumference of the support sleeve 7 is vertically provided with a rectangular groove for the connecting plate 41 to slide up and down. The opening of the rectangular groove can play a role in limiting the connection plate 41. The end of the connecting plate 41 away from the circular plate 32 is fixedly connected with a linkage rod 42, and the two ends of the linkage rod 42 are symmetrically fixedly connected with two pressing plates 43. When the circular plate 32 moves down, the connecting plate 41 is driven to move down with the linkage rod 42, causing the two pressing plates 43 to move down to squeeze the bottom drug suction bag 44, and when the circular plate 32 moves up, the two pressing plates 43 drive the bottom drug suction bag 44 to reset. The bottom of the two pressing plates 43 is fixedly connected with two drug suction bags 44 fixedly connected with the top of the reaction box 1, and the circumference of the top of the two drug suction bags 44 is fixedly connected with a one-way drug suction tube 45, and the bottom of the two drug suction bags 44 is fixedly connected with a one-way drug discharge tube 46 connected with the inner cavity of the reaction box 1, and the one-way drug suction tube 45 and the one-way drug discharge tube 46 are installed with a one-way valve inside. The drug storage tanks of the raw materials required for the production of dextran iron injection are respectively connected to the two one-way drug suction tubes 45. When the pressing plate 43 is pressed against the drug suction bag at the bottom When 44 is extruded, the drug suction bag 44 discharges the raw materials sucked through the one-way drug suction tube 45 into the reaction box 1 through the one-way drug discharge tube 46. When the pressure plate 43 drives the drug suction bag 44 at the bottom to reset, the drug suction bag 44 that has emptied the raw materials will again suck the raw materials in the drug storage tank through the one-way drug suction tube 45. The above cycle can achieve small and multiple additions. Combined with the small and multiple additions of raw materials and the up and down movement and forward and reverse rotation of the stirring blade 2, the stirring uniformity of the solution can be effectively improved, which is beneficial to ensuring the stability of the reaction process and the quality of the product.

[0030] Example 2

[0031] Based on Example 1, Figure 5When the solution at the bottom of the reaction box 1 is mixed with the raw materials, it will be deposited and form a large bottom mixture layer, resulting in an obvious concentration difference between the solution in the bottom area and the upper solution, thereby affecting the uniformity of the solution. In order to prevent the above phenomenon from occurring, the following arrangement is made: an expansion stirring blade 5 is slidably sleeved on the end of the stirring blade 2 away from the columnar barrel 35, and an expansion stirring component 6 is arranged inside the columnar barrel 35 for allowing the expansion stirring blade 5 to cyclically contract according to the moving path of the stirring blade 2. The expansion stirring component 6 includes a connecting hole groove 61 opened on the inner wall of the columnar barrel 35, and a gravity plate 63 is slidably sleeved inside the connecting hole groove 61. A limit groove for limiting the vertical movement of the gravity plate 63 is opened on the inner wall of the connecting hole groove 61, and the gravity plate 63 is slidably sleeved inside the limit groove. The bottom of the gravity plate 63 is fixedly connected to the buoyancy bag 62, the end surface of the expansion stirring blade 5 is fixedly connected to the sliding plate 65 slidably sleeved inside the stirring blade 2, the circumference of the sliding plate 65 is fixedly connected to the sliding block, and the inner wall of the stirring blade 2 is provided with a sliding groove for the sliding block to slide horizontally. The outer wall of the expansion stirring blade 5 near one end of the stirring blade 2 is sleeved with a spring 66, and the two ends of the spring 66 are fixedly connected to the sliding plate 65 and the stirring blade 2 respectively. The interior of the connecting hole groove 61 is filled with gas 64, and the connecting hole groove 61 is connected to the interior of the stirring blade 2. The gas 64 is sandwiched between the gravity plate 63 and the sliding plate 65. When the stirring blade 2 gradually moves downward in the solution, the buoyancy of the buoyancy bag 62 in the columnar tube 35 will increase. As the buoyancy increases, the buoyancy bag 62 will push the gravity plate 63 to move upward in the connecting hole groove 61 to squeeze the gas 64. The gas 64 is squeezed and pushes the sliding plate 65 to gradually widen the stirring range of the expansion stirring blade 5, which can effectively mix the bottom sediment with the upper solution. When the stirring blade 2 gradually moves upward in the solution, the buoyancy of the buoyancy bag 62 gradually decreases, and the expansion stirring blade 5 pushes the gas 64 back to its original position through the elastic force of the spring 66. The above cycle can further reduce the concentration difference, thereby improving the uniformity of the entire reaction system.

[0032] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A stirring device for preparing dextran, comprising a reaction box (1) and a feed pipe (11) and a discharge pipe (12) fixedly connected to the reaction box (1), characterized in that: A stirring blade (2) is arranged inside the reaction box (1), and a mixing component (3) is arranged on the top of the reaction box (1) for driving the stirring blade (2) to vertically reciprocate and stir the solution in the reaction box (1), and a feeding mechanism (4) is arranged for adding small amounts of raw materials required for production multiple times under the synchronous driving of the mixing component (3); The mixing assembly (3) comprises a cylinder (31) arranged on the top of the reaction box (1); the telescopic end of the cylinder (31) is rotatably connected to a circular plate (32); the bottom of the circular plate (32) is rotatably connected to a rotary rod (33); the outer wall of the rotary rod (33) is threadedly connected to a driving block (34) fixedly connected to the inner wall of the reaction box (1); the outer wall of the rotary rod (33) is fixedly connected to a columnar barrel (35); and the stirring blade (2) is fixed to the outer wall of the columnar barrel (35).

2. A stirring device for preparing dextran according to claim 1, characterized in that, The feeding mechanism (4) comprises a connecting plate (41) fixed on the circumferential surface of the circular plate (32), one end of the connecting plate (41) away from the circular plate (32) is fixedly connected to a linkage rod (42), and two ends of the linkage rod (42) are symmetrically fixedly connected to two pressure plates (43).

3. A stirring device for preparing dextran according to claim 2, characterized in that, The bottoms of the two pressing plates (43) are fixedly connected to two drug suction bags (44) which are fixedly connected to the top of the reaction box (1); the circumferential surfaces of the top ends of the two drug suction bags (44) are fixedly connected to a one-way drug suction tube (45); and the bottom ends of the two drug suction bags (44) are fixedly connected to a one-way drug discharge tube (46) which is connected to the inner cavity of the reaction box (1).

4. A stirring device for preparing dextran according to claim 1, characterized in that: An expanding stirring blade (5) is slidably sleeved on one end of the stirring blade (2) away from the columnar tube (35), and an expanding stirring assembly (6) is provided inside the columnar tube (35) for allowing the expanding stirring blade (5) to cyclically contract according to the moving path of the stirring blade (2).

5. A stirring device for preparing dextran according to claim 4, characterized in that: The expansion and stirring assembly (6) comprises a communication hole groove (61) provided on the inner wall of the columnar tube (35), the internal sliding sleeve of the communication hole groove (61) is provided with a gravity plate (63), and the bottom of the gravity plate (63) is fixedly connected with a buoyancy bag (62).

6. A stirring device for preparing dextran according to claim 4, characterized in that: The end surface of the expanding stirring blade (5) is fixedly connected to a sliding plate (65) which is slidably sleeved inside the stirring blade (2); the outer wall of the expanding stirring blade (5) close to one end of the stirring blade (2) is sleeved with a spring (66); the two ends of the spring (66) are respectively fixedly connected to the sliding plate (65) and the stirring blade (2).

7. A stirring device for preparing dextran according to claim 5, characterized in that: The communicating hole groove (61) is filled with gas (64), the communicating hole groove (61) is connected with the inside of the stirring blade (2), and the gas (64) is sandwiched between the gravity plate (63) and the sliding plate (65).

8. A stirring device for preparing dextran according to claim 1, characterized in that: The top of the reaction box (1) is fixedly connected to a support sleeve (7) which is fixedly connected to the bottom of the cylinder (31), and a rectangular groove for the connecting plate (41) to slide up and down is vertically opened on the peripheral surface of the support sleeve (7).

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