Micro-fluidic chip pressing device and micro-fluidic biological analyzer

Abstract

The utility model discloses a micro-fluidic chip pressing device and a micro-fluidic biological analyzer, and relates to the technical field of microfluidics, the micro-fluidic chip pressing device comprises a conveying tray 1, a tray connecting plate 3 and a chip tray 7 used for containing a micro-fluidic chip 2; the conveying tray 1 and the tray connecting plate 3 are connected through the guide shaft 4 to form a fixed frame; the chip tray 7 is provided with a guide bearing 5 and is sleeved on the guide shaft 4 through the guide bearing 5, so that the chip tray 7 can slide up and down along the guide shaft 4; a spring piece 6 is installed at the bottom of the chip tray 7, the chip tray 7 is driven to downwards compress the spring piece 6 in the process that the micro-fluidic chip 2 is pressed downwards, and after the micro-fluidic chip 2 is loosened, the spring piece 6 enables the micro-fluidic chip 2 to be reset to the original height position under the action of resilience force, and the micro-fluidic chip 2 is not in contact with a gas circuit board. By adopting the micro-fluidic chip pressing device, the automation degree of use of the micro-fluidic chip is improved, and the use efficiency of the micro-fluidic chip is further improved.

Description

Technical Field

[0001] The present application relates to the field of microfluidic technology, and in particular to a microfluidic chip pressing device and a microfluidic bioanalyzer. Background Art

[0002] Microfluidics chip technology integrates the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis process onto a micrometer-scale chip to automatically complete the entire analysis process. Microfluidics chips are currently a hot area in the development of micro-total analysis systems.

[0003] Microfluidic chip analysis uses the chip as the operating platform, is based on analytical chemistry, relies on micro-electromechanical processing technology, has a micro-channel network as the structural feature, and is currently mainly applied to life sciences. It is the focus of the current development of the micro-total analysis system. Its goal is to integrate the functions of the entire laboratory, including sampling, dilution, reagent addition, reaction, separation, detection, etc., on a microchip, and it can be used multiple times. In the process of producing microfluidic chips, it is necessary to pre-embed a variety of reagents in the chip, such as lysate, washing solution, eluent, etc.

[0004] In practical applications, the microfluidic chip needs to be placed on top of the gas path plate and pressed tightly, and then the corresponding operation is performed. After the operation is completed, the microfluidic chip is released and taken out.

[0005] Currently, microfluidic chips are usually placed manually and pressed manually, with a low degree of automation, resulting in low efficiency. Utility Model Content

[0006] The embodiments of the present application provide a microfluidic chip pressing device and a microfluidic bioanalyzer to solve the problem of low utilization efficiency of microfluidic chips in the prior art.

[0007] The present application embodiment provides a microfluidic chip pressing device for a microfluidic bioanalyzer, comprising:

[0008] A conveying tray 1, a tray connecting plate 3 and a chip tray 7 for holding a microfluidic chip 2;

[0009] The conveying tray 1 and the tray connecting plate 3 are connected to form a fixed frame via a guide shaft 4;

[0010] The chip tray 7 is installed with a guide bearing 5, and the guide bearing 5 is sleeved on the guide shaft 4, so that the chip tray 7 can slide up and down along the guide shaft 4;

[0011] A spring sheet 6 is installed at the bottom of the chip tray 7. When the microfluidic chip 2 is pressed downward, the chip tray 7 is driven to compress the spring sheet 6 downward. After the microfluidic chip 2 is released, the spring sheet 6 restores the microfluidic chip 2 to its original height position under the action of the rebound force, and breaks contact with the gas circuit board.

[0012] Furthermore, the conveying tray 1 is connected to the conveying mechanism of the microfluidic bioanalyzer, and the conveying tray 1 is used to place the microfluidic chip 2 above the gas path plate and move the microfluidic chip 2 from above the gas path plate to other positions under the drive of the conveying mechanism.

[0013] Furthermore, the conveying tray 1 is C-shaped, and the groove area of ​​the C-shaped conveying tray 1 is used to place the tray connecting plate 3, the chip tray 7 and the microfluidic chip 2.

[0014] Furthermore, the chip tray 7 is C-shaped, and the groove area of ​​the C-shaped chip tray 7 is used to place the microfluidic chip 2.

[0015] Furthermore, the chip tray 7 is in an E-shape, and two groove areas of the E-shaped chip tray 7 are used to place one of the microfluidic chips 2 respectively.

[0016] Furthermore, the spring sheet 6 is located at the bottom side of the chip tray 7 .

[0017] The present application also provides a microfluidic bioanalyzer, comprising:

[0018] Any of the microfluidic chip pressing devices described above.

[0019] Furthermore, it also includes:

[0020] The conveying mechanism is used to be connected to the conveying tray 1, drive the conveying tray 1 to place the microfluidic chip 2 above the gas path plate, and move the microfluidic chip 2 from above the gas path plate to other positions.

[0021] Furthermore, it also includes:

[0022] The pressing mechanism is used to drive the microfluidic chip 2 to move downward and press the microfluidic chip 2 onto the gas path plate.

[0023] The beneficial effects of this application include:

[0024] The microfluidic chip clamping device provided in the embodiment of the present application is characterized in that it is used for a microfluidic bioanalyzer, and includes: a conveying tray 1, a tray connecting plate 3 and a chip tray 7 for holding a microfluidic chip 2. The conveying tray 1 and the tray connecting plate 3 are connected to form a fixed frame through a guide shaft. The chip tray 7 is equipped with a guide bearing 5, and is sleeved on the guide shaft 4 through the guide bearing 5, so that the chip tray 7 can slide up and down along the guide shaft 4. A spring sheet 6 is installed at the bottom of the chip tray 7. When the microfluidic chip 2 is pressed downward, it drives the chip tray 7 to compress the spring sheet 6 downward. After the microfluidic chip 2 is released, the spring sheet 6 resets the microfluidic chip 2 to its original height position under the action of the rebound force, and breaks contact with the gas circuit plate. By adopting the microfluidic chip clamping device, the microfluidic chip can be automatically placed on the gas path plate and automatically clamped during use. After the microfluidic chip is released, it can automatically return to its original position under the action of the rebound force of the spring sheet, thereby improving the automation degree of the use of the microfluidic chip and further improving the use efficiency of the microfluidic chip.

[0025] Other features and advantages of the present application will be described in the following description, and partly become apparent from the description, or be understood by practicing the present application. The purpose and other advantages of the present application can be realized and obtained by the structures specifically pointed out in the written description, claims, and drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings are used to provide a further understanding of the present application and constitute a part of the specification. Together with the embodiments of the present application, they are used to explain the present application and do not constitute a limitation of the present application. In the accompanying drawings:

[0027] Figure 1 A schematic diagram of the three-dimensional structure of a microfluidic chip clamping device provided in an embodiment of the present application;

[0028] Figure 2 A schematic diagram of the front structure of the microfluidic chip clamping device provided in the application embodiment;

[0029] Figure 3 A schematic diagram of the cross-sectional structure of the microfluidic chip clamping device at position A provided in the application embodiment;

[0030] Figure 4 A schematic diagram of the rear view structure of the microfluidic chip clamping device provided in the application embodiment;

[0031] Figure 5 A schematic diagram of the top view of the microfluidic chip clamping device provided in the application embodiment;

[0032] Figure 6 A bottom-up structural schematic diagram of the microfluidic chip clamping device provided in the application embodiment. DETAILED DESCRIPTION

[0033] In order to provide an implementation scheme for improving the efficiency of the use of microfluidic chips, the embodiments of the present application provide a microfluidic chip clamping device and a microfluidic bioanalyzer. The preferred embodiments of the present application are described below in conjunction with the drawings of the specification. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present application, and are not used to limit the present application. In addition, the embodiments in the present application and the features in the embodiments can be combined with each other if there is no conflict.

[0034] The present application embodiment provides a microfluidic chip pressing device for a microfluidic bioanalyzer, such as Figure 1-6 As shown, including:

[0035] For use in microfluidic bioanalyzers, including:

[0036] A conveying tray 1, a tray connecting plate 3 and a chip tray 7 for holding a microfluidic chip 2;

[0037] The conveying tray 1 and the tray connecting plate 3 are connected to form a fixed frame via a guide shaft 4;

[0038] The chip tray 7 is installed with a guide bearing 5, and is sleeved on the guide shaft 4 through the guide bearing 5, so that the chip tray 7 can slide up and down along the guide shaft 4;

[0039] A spring sheet 6 is installed at the bottom of the chip tray 7. When the microfluidic chip 2 is pressed downward, the chip tray 7 is driven to compress the spring sheet 6 downward. After the microfluidic chip 2 is released, the spring sheet 6 restores the microfluidic chip 2 to its original height position under the action of the rebound force, and breaks contact with the gas circuit board.

[0040] By using the above-mentioned microfluidic chip clamping device provided in the embodiment of the present application, it is possible to automatically place the microfluidic chip on the gas path plate and automatically clamp it during the use of the microfluidic chip. After the microfluidic chip is released, it can automatically return to its original position under the action of the rebound force of the spring sheet, thereby improving the degree of automation in the use of the microfluidic chip and further improving the use efficiency of the microfluidic chip.

[0041] In one embodiment of the present application, the conveying tray 1 can be connected to the conveying mechanism of the microfluidic bioanalyzer, and the conveying tray 1 is used to place the microfluidic chip 2 above the gas path plate and move the microfluidic chip 2 from above the gas path plate to other positions under the drive of the conveying mechanism.

[0042] Furthermore, the microfluidic chip 2 can be driven by the pressing mechanism of the microfluidic bioanalyzer to move downward and be pressed against the gas path plate, thereby further improving the degree of automation and efficiency.

[0043] In one embodiment of the present application, Figure 1-6 As shown, the conveying tray 1 may be C-shaped, and the groove area of ​​the C-shaped conveying tray 1 is used to place the tray connecting plate 3 , the chip tray 7 and the microfluidic chip 2 .

[0044] Furthermore, the chip tray 7 may be C-shaped, and the groove area of ​​the C-shaped chip tray 7 is used to place the microfluidic chip 2 .

[0045] In one embodiment of the present application, Figure 1-6 As shown, the chip tray 7 may also be in an E-shape, and the two groove areas of the E-shaped chip tray 7 are used to place a microfluidic chip 2 respectively, that is, one chip tray 7 can place two microfluidic chips 2 at the same time, so that two microfluidic chips 2 can be targeted at the same time.

[0046] In one embodiment of the present application, Figure 1-6 As shown, the spring piece 6 can be located at the bottom side of the chip tray 7.

[0047] For example, when the chip tray 7 is in an E-shape, spring sheets 6 may be provided on both sides of the bottom of the chip tray 7 .

[0048] Accordingly, the present application also provides a microfluidic bioanalyzer, comprising:

[0049] Any of the above microfluidic chip clamping devices.

[0050] Furthermore, the microfluidic bioanalyzer may also include:

[0051] The conveying mechanism is used to be connected to the conveying tray 1, and drive the conveying tray 1 to place the microfluidic chip 2 above the gas path plate, and to move the microfluidic chip 2 from above the gas path plate to other positions.

[0052] Furthermore, the microfluidic bioanalyzer may also include:

[0053] The pressing mechanism is used to drive the microfluidic chip 2 to move downward and press the microfluidic chip 2 onto the gas path plate.

[0054] In the embodiments of the present application, the microfluidic bioanalyzer may be any known instrument for performing bioanalysis on a microfluidic chip, for example, a nucleic acid amplification fluorescence detection analyzer.

[0055] In the embodiment of the present application, the conveying mechanism of the microfluidic bioanalyzer can be a motor, and is meshed and connected with the rack of the conveying tray 1 of the clamping device through a gear, so as to drive the movement of the conveying tray 1, so as to realize the conveying of the microfluidic chip 2 placed on the conveying tray 1 to the bottom of the clamping station of the microfluidic bioanalyzer, and also to the top of the gas circuit board. Next, the clamping mechanism of the microfluidic bioanalyzer automatically presses the microfluidic chip 2 downward on the gas circuit board. After all corresponding operations are performed on the microfluidic chip 2, the clamping mechanism releases the microfluidic chip 2. The microfluidic chip 2 is reset to its original height position under the action of the rebound force of the spring sheet 6 and is out of contact with the gas circuit board. The conveying mechanism of the microfluidic bioanalyzer realizes the conveying of the microfluidic chip 2 to other positions by driving the movement of the conveying tray 1, so as to facilitate the removal of the microfluidic chip 2 and enter the operation for the next group of microfluidic biochips 2.

[0056] Compared with the prior art, the degree of automation in the use of microfluidic chips is improved, thereby improving the efficiency of the use of microfluidic chips; moreover, the pressing device provided in the embodiment of the present application is more adaptable to the needs of various automated detection instruments, and solves the problems of complex manual pressing operation of chips, low efficiency, and easy contamination of samples.

[0057] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0058] Obviously, those skilled in the art can make various changes and modifications to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application is also intended to include these modifications and variations.

Claims

1. A microfluidic chip pressing device, characterized in that: For use in microfluidic bioanalyzers, including: A conveying tray (1), a tray connecting plate (3) and a chip tray (7) for holding a microfluidic chip (2); The conveying tray (1) and the tray connecting plate (3) are connected to form a fixed frame via a guide shaft (4); The chip tray (7) is equipped with a guide bearing (5), and the guide bearing (5) is sleeved on the guide shaft (4), so that the chip tray (7) can slide up and down along the guide shaft (4); A spring sheet (6) is installed at the bottom of the chip tray (7). When the microfluidic chip (2) is pressed downward, the chip tray (7) is driven to compress the spring sheet (6) downward. After the microfluidic chip (2) is released, the spring sheet (6) resets the microfluidic chip (2) to its original height position under the action of the rebound force, and the microfluidic chip (2) is separated from the gas circuit board.

2. The pressing device according to claim 1, characterized in that: The conveying tray (1) is connected to a conveying mechanism of the microfluidic bioanalyzer, and the conveying tray (1) is used to place the microfluidic chip (2) above the gas path plate and to move the microfluidic chip (2) from above the gas path plate to other positions under the drive of the conveying mechanism.

3. The pressing device according to claim 1, characterized in that: The conveying tray (1) is C-shaped, and the groove area of ​​the C-shaped conveying tray (1) is used to place the tray connecting plate (3), the chip tray (7) and the microfluidic chip (2).

4. The pressing device according to claim 1, characterized in that: The chip tray (7) is C-shaped, and the groove area of ​​the C-shaped chip tray (7) is used to place the microfluidic chip (2).

5. The pressing device according to claim 1, characterized in that: The chip tray (7) is in an E-shape, and the two groove areas of the E-shaped chip tray (7) are used to place one of the microfluidic chips (2) respectively.

6. The pressing device according to claim 1, characterized in that: The spring sheet (6) is located on the bottom side of the chip tray (7).

7. A microfluidic bioanalyzer, characterized in that: include: The microfluidic chip pressing device according to any one of claims 1 to 6.

8. The microfluidic bioanalyzer according to claim 7, characterized in that: Also includes: A conveying mechanism is used to be connected to the conveying tray (1) to drive the conveying tray (1) to place the microfluidic chip (2) above the gas path plate, and to move the microfluidic chip (2) from above the gas path plate to other positions.

9. The microfluidic bioanalyzer according to claim 7, characterized in that: Also includes: The pressing mechanism is used to drive the microfluidic chip (2) to move downward and to press the microfluidic chip (2) onto the gas path plate.

Images