Cell material transportation device with temperature exceeding threshold value visible

Abstract

The utility model discloses a cell material transportation device with a visible temperature exceeding a threshold value. The cell material transportation device comprises an outer box body, a heat preservation box, an inner partition plate, a temperature adjusting device and a cell culture container loaded with an irreversible thermochromic material. The outer layer of the outer box body is covered with an outer packaging layer, and the heat preservation box is arranged in the outer box body in a sleeved mode. An inner partition plate is arranged in the heat preservation box in a sleeved mode, a concave container containing groove is formed in the inner partition plate, the container containing groove is used for containing the cell culture container, and the size of the container containing groove is matched with that of the cell culture container; the temperature adjusting device is arranged below the container containing groove. According to the cell material transportation device, the temperature range of the cell material in the transportation process is indicated through the color change of the irreversible thermochromic material, so that an operator can intuitively know whether cells are in an extreme temperature environment for the cells in the transportation process without observation under a microscope before the cells are transferred into a sterile room.

Description

Technical Field

[0001] The utility model belongs to the technical field of biological sample logistics, and relates to a cell material transportation device with visible temperature exceeding a threshold value. Background Art

[0002] Cell materials are important research tools in the field of life medicine. The National Model and Characteristic Experimental Cell Resource Bank provides experimental cell materials free of charge to major universities, hospitals, and research institutes across the country. The optimal culture temperature for most cells is 37°C, and the non-injury temperature range is 10°C-40°C. my country has a vast geographical area and distinct four seasons. If no insulation measures are taken, cells will "die of heat" in summer and "freeze to death" in winter during transportation. Adding heating devices such as self-heating bags to cell material transportation devices in winter can help cells cope with cold weather, but the heating bags may release heat unevenly, and high temperatures may occur instantly or for a short time, causing irreversible damage to cells and making it difficult to observe in time. When the temperature exceeds 35°C in summer, if the cell materials are exposed to the sun for a long time during transportation, the cell materials may be exposed to extreme temperatures above 45°C, causing irreversible damage to the cells. Therefore, adding cool water bags or ice bags to the cell material transportation devices can effectively adjust the temperature in the transportation devices. However, the temperature may be too low. Some cells do not change their morphology after being exposed to too high or too low temperatures, but their growth rate is extremely slow after one passage, which leads to a waste of time and energy for researchers. Previously, there was an existing technology that installed an electronic temperature control device in the cell transport device and connected it to an APP to detect the temperature during cell transport in real time. However, the device is expensive and is not practical to implement.

[0003] Therefore, a transportation device is needed that is simple, convenient, low-cost, and can intuitively understand whether the cells have exceeded the temperature threshold due to the transportation environment without the need for microscopic observation or cultivation for a period of time. This will facilitate users to provide timely feedback on the cell status, and the shipper can provide users with after-sales processing and compensation as soon as possible, thereby improving user satisfaction. Utility Model Content

[0004] In order to solve the deficiencies of the prior art, the purpose of the utility model is to provide a cell material transportation device with visible temperature over-threshold value. When the cell material is at a temperature threshold that is too high or too low, the color of the coating, label or ink changes irreversibly and becomes fixed, indicating that the cell material is in a poor state or has died due to extreme temperatures during transportation. The utility model can effectively detect and record the excessively high or low ambient temperature during cell transportation, ensuring that the cell material in good growth state is always within the optimal temperature range during transportation, reducing the time, energy and material resources wasted by the recipient on damaged cell materials.

[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0006] A cell material transport device with visible temperature exceeding threshold value, the transport device comprising an outer box, an insulated box, an inner partition, a temperature regulating device, and a cell culture container;

[0007] The outer layer of the outer box is covered with a waterproof and wear-resistant outer packaging layer, and the thermal insulation box is placed inside; an inner partition is arranged inside the thermal insulation box, and a concave container placement groove is arranged on the inner partition, and the container placement groove is used to place the cell culture container, and the size of the container placement groove matches the cell culture container; the temperature control device is arranged below the container placement groove.

[0008] The shape of the outer box is an n1 prism, n1≥4; the length of the bottom side of the outer box is in the range of 14-100 cm, and the height is in the range of 10-70 cm; preferably, when n1=4, the bottom side is 27 cm long, 16 cm wide and 19 cm high; when n1=5, the bottom side is 15 cm long and 20 cm high; when n1=6, the bottom side is 12 cm long and 20 cm high.

[0009] The incubator is placed inside the outer box, and the shape of the incubator matches that of the outer box, which is an n2 prism, where n2≥4; the length of the bottom side of the incubator is in the range of 12-80cm, and the height is in the range of 8-50cm; preferably, when n2=4, the bottom length of the incubator is 25cm, the width is 15cm, and the height is 18cm; when n2=5, the bottom length of the incubator is 14cm, and the height is 18cm; when n2=6, the bottom length of the incubator is 11cm, and the height is 18cm. The outer wall of the incubator fits with the inner wall of the outer box; in a specific embodiment, the shape of the incubator is the same as that of the outer box, and the size is slightly reduced, so that the incubator can be placed inside the outer box, and at the same time, the incubator is prevented from shaking due to external instability when it is placed inside the outer box.

[0010] The inner partition is placed inside the incubator to separate the cell culture container and the temperature regulating device from the fixed cell culture container; the inner partition includes a horizontal partition, which is supported by a vertical partition below; the outer sides of the horizontal partition and the vertical partition are in contact with the inner wall of the incubator; the horizontal partition and the vertical partition are combined to form a partition cavity, which is located below the horizontal partition; the inner partition is 10-70 cm long and 10-70 cm wide. The range is 6-40cm, and the range of height is 7-50cm; preferably, the shape of the horizontal partition matches the shape of the insulation box, which is an n3 prism shape, n3≥4; when n3=4, the length of the horizontal partition is 23cm, the width is 12cm, and the inner partition height is 14cm; when n3=5, the side length of the horizontal partition is 13cm, and the inner partition height is 16cm; when n3=6, the bottom side length of the horizontal partition is 10cm, and the inner partition height is 16cm.

[0011] One or more concave container placement grooves are arranged above the horizontal partition.

[0012] The size of the concave container placement groove is formulated according to the T25-T75 cell culture container, so that the cell culture container can be matched and placed in the container placement groove without the cell culture container body shaking.

[0013] The temperature regulating device is arranged in the partition cavity, the volume of the temperature regulating device is smaller than the volume of the partition cavity, and the surface area of ​​the temperature regulating device is greater than or equal to the area of ​​the container placement groove;

[0014] The temperature regulating device includes a temperature increasing device and / or a temperature decreasing device; the temperature increasing device includes: one or more of a self-heating heating pack, a heat preservation bag, and a hot water bag; the temperature decreasing device includes: one or both of an ice bag and an ice tray.

[0015] The surface area of ​​the temperature regulating device is greater than or equal to 75 cm 2 , less than or equal to 150cm 2 , the recommended surface area is 100cm 2 .

[0016] The outer surface of the cell culture container is provided with an irreversible thermochromic material, and the irreversible thermochromic material includes an ultra-high temperature irreversible thermochromic material and an ultra-low temperature irreversible thermochromic material, which can change color when exceeding or falling below a color change threshold; specifically, when the temperature exceeds the high temperature color change threshold, the color of the ultra-high temperature irreversible thermochromic material changes, and when the temperature is lower than the low temperature color change threshold, the color of the ultra-low temperature irreversible thermochromic material changes; the irreversible thermochromic material includes a protective layer, a color change layer, a printing layer, and an adhesive layer from the outside to the inside; the adhesive layer is used to adhere the irreversible thermochromic material to the outside of the cell culture container, the printing layer is used to print the color change coating, ink, etc. to form a color change layer, and the protective layer covers the color change layer to protect the color change layer from being worn due to movement, friction, etc.;

[0017] In a specific embodiment, the irreversible thermochromic material is rectangular, with a length ranging from 1-5 cm and a width ranging from 0.5-2 cm; preferably, the thermochromic material is 2 cm long and 1 cm wide; according to actual needs, the irreversible thermochromic material can also be made into other regular or irregular shapes.

[0018] A temperature colorimetric card is also arranged outside the cell culture container, and the temperature colorimetric card is used to calibrate the color of the irreversible thermochromic material at different temperatures.

[0019] In a specific embodiment, a high-temperature irreversible thermochromic material, a low-temperature irreversible thermochromic material, and a temperature colorimetric card are arranged on the outside of the cell culture container; the high-temperature irreversible thermochromic material, the low-temperature irreversible thermochromic material, and the temperature colorimetric card are arranged in a straight line along the axial direction of the outside of the cell culture container.

[0020] In a specific embodiment, a cell culture container carrying an irreversible thermochromic material is arranged on an inner partition; the temperature regulating device is arranged under the inner partition; the inner partition, the temperature regulating device, and the cell culture container carrying the irreversible thermochromic material are all firmly arranged in an incubator; the incubator is arranged in an outer box, and the outer wall of the incubator is in contact with the inner wall of the outer box; the outer box is arranged in an outer packaging layer;

[0021] The temperature regulating device includes a heating device and a cooling device; the heating device is selected from one or more of a self-heating bag, a heat preservation bag, a hot water bag, etc.; the cooling device is selected from one or two of an ice bag, an ice tray, etc.;

[0022] The cell culture container is selected from one or more of a cell culture bottle, a cell culture well plate, a cell culture dish, a centrifuge tube, etc.;

[0023] An irreversible thermochromic material (including one ultra-high temperature irreversible thermochromic material A and one ultra-low temperature irreversible thermochromic material B) and a temperature colorimetric card are carried on the outer wall of the cell culture container on one side of the container close to the temperature regulating device;

[0024] The irreversible thermochromic material is selected from one or more of an irreversible thermochromic coating, an irreversible thermochromic label, an irreversible thermochromic ink, and the like.

[0025] The utility model provides a cell material transport device with visible temperature exceeding threshold value, which has the following beneficial effects:

[0026] The structure and material of the outer box of the temperature-overthreshold visible cell material transport device of the utility model make it foldable, strong, well cushioned and not easily damaged, convenient for long-distance transport and low in transport cost.

[0027] The outer box of the temperature-exceeding-threshold-visible cell material transport device of the utility model is made of recyclable materials, and the interior is made of thermal insulation materials and buffer materials. It has good environmental protection and energy-saving performance and meets the requirements of modern society for environmental protection and energy saving.

[0028] The overall structure and material selection of the temperature-overthreshold visible cell material transport device of the utility model enable it to have heat preservation, heat insulation, buffering and waterproof capabilities, and can effectively solve the impact of temperature changes, severe shocks and changes in the culture system on cell vitality and status during long-distance transportation.

[0029] The installation position and material selection of the irreversible thermochromic material of the temperature exceeding threshold value visible cell material transportation device of the utility model enable it to accurately reflect the highest and lowest temperatures experienced by the cells in the cell culture container, which can effectively reduce the time, energy and material resources wasted by the receiving user on damaged cell materials.

[0030] The temperature exceeding threshold value visible cell material transport device of the utility model has simple structure, strong versatility and low cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For those skilled in the art, other drawings can be obtained based on these drawings without paying creative work.

[0032] Figure 1 This is a schematic diagram of the appearance of the cell material transport device with visible temperature exceeding a threshold value according to the present invention.

[0033] Figure 2 It is a schematic diagram of the outer box structure of the cell material transport device with visible temperature exceeding threshold value described in the utility model.

[0034] Figure 3 It is a structural schematic diagram of an incubator box of a cell material transport device with visible temperature exceeding a threshold value according to the utility model.

[0035] Figure 4 It is a schematic structural diagram of an inner partition of a cell material transport device with visible temperature exceeding a threshold value according to the utility model.

[0036] Figure 5 The utility model is a schematic diagram of the combination of an incubator, an inner partition, a temperature regulating device, and a cell culture container carrying an irreversible thermochromic material of the cell material transport device with visible temperature exceeding a threshold value.

[0037] Figure 6 It is a schematic diagram of a cell culture container carrying an irreversible thermochromic material of the cell material transport device with visible temperature exceeding a threshold value described in the utility model.

[0038] Figure 7 It is a schematic diagram of the structure of the irreversible thermochromic material of the cell material transport device with visible temperature exceeding a threshold value described in the utility model.

[0039] Figure 8 This is a schematic diagram of the disassembly of the cell material transport device with visible temperature exceeding a threshold value according to the utility model.

[0040] Figure 1-Figure 8 In the figure, 1-outer packaging layer, 2-outer box body, 3-insulation box, 4-inner partition, 5-temperature regulating device, 6-cell culture container. DETAILED DESCRIPTION

[0041] The utility model is further described in detail with reference to the following specific embodiments and drawings. The process, conditions, experimental methods, etc. for implementing the utility model, except for the contents specifically mentioned below, are all common knowledge and common common sense in the field, and the utility model has no special restrictions.

[0042] The utility model provides a cell material transport device with visible temperature over-threshold value, which comprises an outer box 2, an incubator 3, an inner partition 4, a temperature regulating device 5, and a cell culture container 6 carrying an irreversible thermochromic material. The cell material transport device indicates the temperature range of the cell material during the transportation process by the color change of the irreversible thermochromic material, so that the operator can intuitively understand whether the cell is in an extreme temperature environment for it during the transportation process before transferring the cell into the sterile room without observing under a microscope.

[0043] See also Figure 1-8 The temperature-exceeding-threshold-visible cell material transport device of the utility model comprises an outer box 2, an incubator 3, an inner partition 4, a temperature regulating device 5, and a cell culture container 6 carrying an irreversible thermochromic material.

[0044] Specifically, the outer packaging layer 1 is arranged to cover the outer box body 2, and the outer packaging layer 1 has waterproof and wear-resistant functions, and is selected from one or more of polyethylene low-foaming waterproof barrier film, composite film, plastic film, oil paper, kraft paper, polypropylene, and polylactic acid;

[0045] Specifically, the outer box 2 is arranged outside the heat preservation box 3, and the outer box 2 has a supporting function and is selected from one or more of a carton, a corrugated box, and a calcium plastic box;

[0046] Specifically, the heat preservation box 3 is arranged in the outer box body 2, and the outer wall of the heat preservation box is in contact with the inner wall of the outer box body, and has the function of heat preservation and pressure resistance. The heat preservation box is selected from one or more of heat-insulating pearl cotton, heat-insulating glass wool, polyurethane foam plastic, aluminum silicate wool, high-pressure polyethylene, and polystyrene foam plastic;

[0047] Specifically, the inner partition 4, the temperature regulating device 5, and the cell culture container 6 carrying the irreversible thermochromic material are all arranged in the incubator 3, and the front, back, left and rear four sides of the inner partition 4 are in contact with the incubator 3; a container placement groove is provided above the inner partition 4, and the shape of the container placement groove matches the cell culture container 6; a partition cavity is formed below the inner partition 4, and the volume of the partition cavity is larger than the volume of the temperature regulating device 5;

[0048] The inner partition 4 is firmly placed in the incubator 3 and has the functions of separating the cell culture container and the temperature regulating device and fixing the cell culture container. The inner partition 4 is selected from one or more of polyurethane foam plastics, high-pressure polyethylene, polystyrene foam plastics and the like.

[0049] Specifically, the temperature regulating device 5 is arranged under the inner partition 4, and has a temperature control function, including a heating device and / or a cooling device; the heating device is characterized in that it heats up the temperature inside the box by self-heating, and is selected from one or more of a self-heating bag, a heat preservation bag, a hot water bag, etc. The cooling device is characterized in that it lowers the temperature inside the box, and is selected from one or two of an ice bag, an ice tray, etc.;

[0050] Specifically, the cell culture container 6 is selected from one or more of a cell culture bottle, a cell culture plate, a cell culture dish, a centrifuge tube, etc. The outer surface of the cell culture container 6 near the temperature control device 5 carries two irreversible thermochromic materials A and B, which are selected from one or more of an irreversible thermochromic label, an irreversible thermochromic coating, an irreversible thermochromic ink, etc. The irreversible thermochromic material A is an ultra-high temperature irreversible thermochromic material, and the irreversible thermochromic material B is an ultra-low temperature irreversible thermochromic material; a temperature colorimetric card is also provided near the irreversible thermochromic material; the ultra-high temperature irreversible thermochromic material and the ultra-low temperature irreversible thermochromic material have different colors after color change.

[0051] In some embodiments, the outer box 2 and the incubator 3 can be boxes of various shapes or sizes, which can be selected according to actual needs. The shape of the outer box 2 is an n-prism type, n≥4, and a rectangular or cube type is more preferably recommended. The incubator 3 is placed inside the outer box 2 to ensure that the walls of the incubator 3 and the outer box 2 fit together. The inner partition 4 is placed inside the incubator 3 to ensure that the walls of the inner partition and the incubator fit together. A container placement groove is provided above the inner partition 4, and the container placement groove fits with the cell culture container 6 to avoid shaking during transportation, which is beneficial to the maintenance of cell line activity.

[0052] In some embodiments, the temperature regulating device 5 is placed below the container placement groove of the inner partition 4, and the volume of the temperature regulating device 5 is less than the volume of the partition cavity, but the surface area of ​​the temperature regulating device 5 is greater than or equal to the area of ​​the container placement groove of the inner partition 4, so as to ensure that the cell culture container 6 is evenly heated, which is beneficial to maintain the activity of the cell line.

[0053] In some embodiments, the outer surface of the cell culture container 6 on one side of the container close to the temperature control device 5 carries two irreversible thermochromic materials A and B, which are selected from one of an irreversible thermochromic label, an irreversible thermochromic coating, and an irreversible thermochromic ink. The irreversible thermochromic material A is an ultra-high temperature irreversible thermochromic material, which changes color when the ambient temperature is higher than the maximum color change threshold temperature of the thermochromic material. The irreversible thermochromic material B is an ultra-low temperature irreversible thermochromic material, which changes color when the thermochromic coating drops below the minimum color change threshold temperature of the thermochromic material when the ambient temperature drops. Specifically, the minimum threshold is 10°C and the maximum threshold is 40°C, that is, the cell-harmless temperature range is 10°C-40°C.

[0054] Please refer to 6. When the ambient temperature exceeds 40°C, the temperature-sensitive coating of the irreversible thermochromic material A (ultra-high temperature irreversible thermochromic material) will change color, and when the temperature is below 10°C, the irreversible thermochromic material B (ultra-low temperature irreversible thermochromic material) will also change color. Among them, the colors of the irreversible thermochromic material A and the irreversible thermochromic material B after color change are different, but the initial states of the irreversible thermochromic material A and the irreversible thermochromic material B are both white or transparent. In addition, the temperature colorimetric card is set after the irreversible thermochromic material A and the irreversible thermochromic material B, and its color does not change with temperature. It is the original color of the irreversible thermochromic material. When the colors of the irreversible thermochromic material A and the irreversible thermochromic material B change, they can be compared with the temperature colorimetric card, thereby making an obvious comparison to avoid being unable to be recognized by the naked eye. Through the effect of the temperature colorimetric card, the irreversible thermochromic material A and the irreversible thermochromic material B after color change can be visually directly compared with the colors in the normal temperature range. Therefore, the thermochromic label can be observed from both low and high temperature directions to determine whether the ambient temperature meets the requirements, which is highly intuitive.

[0055] Among them, the irreversible thermochromic material A and the irreversible thermochromic material B are both composed of 4 layers of materials, which are a protective layer, a color-changing layer, a printing layer, and an adhesive layer from the outside of the container to the container wall; the material of the protective layer is PET or BOPP film, and BOPP film is recommended to cover the upper surface of the color-changing layer; the color-changing layer will change color when the ambient temperature changes beyond its threshold; for the printing layer, it is recommended to select coated paper, which has better adhesion effect during printing and printing ink; the adhesive layer is common oil glue, and it is recommended to be processed by gluing to achieve the effect of making the label stickier and more firmly.

[0056] By monitoring the cell material transport device with visible temperature over-threshold, it is confirmed that the transport device can effectively detect and record the excessively high or low ambient temperature during cell transportation, ensuring that the cell materials in good growth state are always within the optimal temperature range during transportation, so as to accurately understand the state and vitality of the cells, thereby reducing the time, energy and material resources wasted by the recipients on damaged cell materials. Better improve the technical service capabilities and quality of the national model and characteristic experimental cell resource library.

[0057] In the description of the present invention, it should be noted that if the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0058] In the present application, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0059] The disclosure below provides many different embodiments or examples to realize the different structures of the present application. In order to simplify the disclosure of the present application, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present application. In addition, the present application can repeat reference numbers and / or reference letters in different examples, and this repetition is for the purpose of simplification and clarity, which itself does not indicate the relationship between the various embodiments and / or settings discussed. In addition, the various specific processes and material examples provided by the present application, but those of ordinary skill in the art can appreciate the application of other processes and / or the use of other materials.

[0060] Example 1

[0061] This embodiment provides a cell material transport device with visible temperature exceeding threshold value, the cell material transport device comprises an outer box 2, an incubator 3, an inner partition 4, a temperature regulating device 5, and a cell culture container 6;

[0062] The outer box body 2 is a cardboard box, the outer layer of which is covered with a waterproof and wear-resistant outer packaging layer 1 made of oil paper, and the inner part is covered with the thermal insulation box 3 made of insulating glass wool; the inner part of the thermal insulation box 3 is covered with an inner partition 4 made of high-pressure polyethylene, and the inner partition 4 is provided with a concave container placement groove, and the container placement groove is used to place the cell culture container 6, and the size of the container placement groove matches the cell culture container; the temperature control device 5 is arranged below the container placement groove.

[0063] In this embodiment, the outer box 2 and the heat preservation box 3 are both in the shape of a quadrangular prism, that is, a rectangular parallelepiped; the outer wall of the heat preservation box 3 is in contact with the inner wall of the outer box 2; the outer box 2 is 27 cm long, 16 cm wide, and 19 cm high; the heat preservation box 3 is 25 cm long, 15 cm wide, and 18 cm high;

[0064] The inner partition 4 is placed inside the heat preservation box 3, and the side wall of the inner partition 4 is in contact with the inner wall of the heat preservation box 3; the inner partition 4 is 23 cm long, 12 cm wide, and 14 cm high;

[0065] The inner partition 4 includes a horizontal partition, and the horizontal partition is supported by a vertical partition below; the outer sides of the horizontal partition and the vertical partition are in contact with the inner wall of the thermal insulation box 3; the horizontal partition and the vertical partition form a partition cavity, and the partition cavity is located below the horizontal partition;

[0066] A concave container placement groove is arranged above the horizontal partition plate for placing the cell culture container 6 .

[0067] The temperature regulating device 5 is arranged in the partition cavity, the volume of the temperature regulating device 5 is smaller than the volume of the partition cavity, and the surface area of ​​the temperature regulating device 5 is greater than or equal to the area of ​​the container placement groove;

[0068] In this embodiment, the temperature regulating device is a heating device; the heating device is a self-heating heating pack; the surface area of ​​the temperature regulating device is 90cm 2 .

[0069] The outer surface of the cell culture container 6 is provided with an irreversible thermochromic material, and the irreversible thermochromic material includes an ultra-high temperature irreversible thermochromic material and an ultra-low temperature irreversible thermochromic material; the irreversible thermochromic material includes a protective layer, a color changing layer, a printing layer, and an adhesive layer from top to bottom;

[0070] A temperature colorimetric card is also provided on the outside of the cell culture container 6, and the temperature colorimetric card is used to calibrate the color of the irreversible thermochromic material at different temperatures;

[0071] In this embodiment, the temperature in the cell material transport device is higher than 40° C., the irreversible thermochromic material A changes from transparent or milky white to red, and the irreversible thermochromic material B does not change color.

[0072] Example 2

[0073] This embodiment provides a cell material transport device with visible temperature exceeding threshold value, the cell material transport device comprises an outer box 2, an incubator 3, an inner partition 4, a temperature regulating device 5, and a cell culture container 6;

[0074] The outer box body 2 is a corrugated box, the outer layer of which is covered with a waterproof and wear-resistant outer packaging layer 1 made of plastic film material, and the inner part is provided with the thermal insulation box 3 made of polyurethane foam plastic material; the thermal insulation box 3 is provided with an inner partition 4 made of polyurethane foam plastic material, and the inner partition 4 is provided with a concave container placement groove, and the container placement groove is used to place the cell culture container 6, and the size of the container placement groove matches the cell culture container; the temperature control device 5 is arranged below the container placement groove.

[0075] In this embodiment, the outer box 2 and the heat preservation box 3 are both pentagonal prisms; the outer wall of the heat preservation box 3 is in contact with the inner wall of the outer box 2; the side length of the outer box 2 is 15 cm and the height is 20 cm; the side length of the heat preservation box 3 is 14 cm and the height is 18 cm;

[0076] The inner partition 4 is placed inside the heat preservation box 3, and the side wall of the inner partition 4 is in contact with the inner wall of the heat preservation box 3; the side length of the inner partition 4 is 13 cm and the height is 16 cm;

[0077] The inner partition 4 includes a horizontal partition, and the horizontal partition is supported by a vertical partition below; the outer sides of the horizontal partition and the vertical partition are in contact with the inner wall of the thermal insulation box 3; the horizontal partition and the vertical partition form a partition cavity, and the partition cavity is located below the horizontal partition;

[0078] Two concave container placement grooves are arranged above the horizontal partition for placing the cell culture container 6 .

[0079] The temperature regulating device 5 is arranged in the partition cavity, the volume of the temperature regulating device 5 is smaller than the volume of the partition cavity, and the surface area of ​​the temperature regulating device 5 is greater than or equal to the area of ​​the container placement groove;

[0080] In this embodiment, the temperature regulating device is a heating device; the heating device is a heat preservation bag; the surface area of ​​the temperature regulating device is 100cm 2 .

[0081] The outer surface of the cell culture container 6 is provided with an irreversible thermochromic material, and the irreversible thermochromic material includes an ultra-high temperature irreversible thermochromic material and an ultra-low temperature irreversible thermochromic material; the irreversible thermochromic material includes a protective layer, a color changing layer, a printing layer, and an adhesive layer from top to bottom;

[0082] A temperature colorimetric card is also provided on the outside of the cell culture container 6, and the temperature colorimetric card is used to calibrate the color of the irreversible thermochromic material at different temperatures.

[0083] In this embodiment, the temperature in the cell material transport device is 25° C., and the irreversible thermochromic materials A and B do not change color.

[0084] Example 3

[0085] This embodiment provides a cell material transport device with visible temperature exceeding threshold value, the cell material transport device comprises an outer box 2, an incubator 3, an inner partition 4, a temperature regulating device 5, and a cell culture container 6;

[0086] The outer box body 2 is a calcium plastic box, the outer layer of which is covered with a waterproof and wear-resistant outer packaging layer 1 made of kraft paper, and the inner part is provided with the heat-insulating pearl cotton material. The heat-insulating box 3 is placed inside; the inner partition 4 made of polystyrene foam plastic is placed inside the heat-insulating box 3, and the inner partition 4 is provided with a concave container placement groove, and the container placement groove is used to place the cell culture container 6, and the size of the container placement groove matches the cell culture container; the temperature control device 5 is arranged below the container placement groove.

[0087] In this embodiment, the outer box 2 and the heat preservation box 3 are both hexagonal prisms; the outer wall of the heat preservation box 3 fits the inner wall of the outer box 2; the side length of the outer box 2 is 12 cm and the height is 20 cm; the side length of the heat preservation box 3 is 11 cm and the height is 18 cm;

[0088] The inner partition 4 is placed inside the heat preservation box 3, and the side wall of the inner partition 4 is in contact with the inner wall of the heat preservation box 3; the side length of the inner partition 4 is 10 cm and the height is 16 cm;

[0089] The inner partition 4 includes a horizontal partition, and the horizontal partition is supported by a vertical partition below; the outer sides of the horizontal partition and the vertical partition are in contact with the inner wall of the thermal insulation box 3; the horizontal partition and the vertical partition form a partition cavity, and the partition cavity is located below the horizontal partition;

[0090] Three concave container placement grooves are arranged above the horizontal partition plate for placing the cell culture containers 6 .

[0091] The temperature regulating device 5 is arranged in the partition cavity, the volume of the temperature regulating device 5 is smaller than the volume of the partition cavity, and the surface area of ​​the temperature regulating device 5 is greater than or equal to the area of ​​the container placement groove;

[0092] In this embodiment, the temperature regulating device is a cooling device; the cooling device is an ice bag; the surface area of ​​the temperature regulating device is 100cm 2 .

[0093] The outer surface of the cell culture container 6 is provided with an irreversible thermochromic material, and the irreversible thermochromic material includes an ultra-high temperature irreversible thermochromic material and an ultra-low temperature irreversible thermochromic material; the irreversible thermochromic material includes a protective layer, a color changing layer, a printing layer, and an adhesive layer from top to bottom;

[0094] A temperature colorimetric card is also provided on the outside of the cell culture container 6, and the temperature colorimetric card is used to calibrate the color of the irreversible thermochromic material at different temperatures;

[0095] In this embodiment, the temperature in the cell material transport device is lower than 10° C., the irreversible thermochromic material A does not change color, and the irreversible thermochromic material B changes from transparent or milky white to black.

[0096] The protection content of the present invention is not limited to the above embodiments. Without departing from the spirit and scope of the utility model concept, changes and advantages that can be thought of by those skilled in the art are included in the present invention and are protected by the attached claims.

Claims

1. A cell material transport device with visible temperature exceeding threshold, characterized in that: The cell material transport device comprises an outer box (2), an insulated box (3), an inner partition (4), a temperature regulating device (5), and a cell culture container (6); The outer layer of the outer box body (2) is covered with a waterproof and wear-resistant outer packaging layer (1), and the heat preservation box (3) is placed inside; the heat preservation box (3) is provided with an inner partition (4), and the inner partition (4) is provided with a concave container placement groove, the container placement groove is used to place the cell culture container (6), and the size of the container placement groove matches the cell culture container; the temperature control device (5) is arranged below the container placement groove; An irreversible thermochromic material is arranged on the outer surface of the cell culture container (6), and the irreversible thermochromic material can change color when the temperature exceeds or falls below a preset color change threshold.

2. The cell material transport device according to claim 1, characterized in that: The shape of the outer box (2) is an n1 prism, where n1≥4; the height of the outer box (2) is 10-70 cm.

3. The cell material transport device according to claim 2, characterized in that: When n1=4, the bottom side length of the outer box body (2) is 27 cm, the width is 16 cm, and the height is 19 cm; when n1=5, the bottom side length of the outer box body (2) is 15 cm, and the height is 20 cm; when n1=6, the bottom side length of the outer box body (2) is 12 cm, and the height is 20 cm.

4. The cell material transport device according to claim 1, characterized in that: The thermal insulation box (3) is placed inside the outer box body (2); the shape of the thermal insulation box (3) matches the shape of the outer box body (2) and is an n2 prism shape, where n2≥4; the outer wall of the thermal insulation box (3) fits the inner wall of the outer box body (2); the height of the thermal insulation box (3) is 8-50 cm.

5. The cell material transport device according to claim 4, characterized in that: When n2=4, the bottom length of the thermal insulation box (3) is 25 cm, the width is 15 cm, and the height is 18 cm; when n2=5, the bottom side length of the thermal insulation box (3) is 14 cm, and the height is 18 cm; when n2=6, the bottom side length of the thermal insulation box (3) is 11 cm, and the height is 18 cm.

6. The cell material transport device according to claim 1, characterized in that: The inner partition (4) is placed inside the thermal insulation box (3), and the side wall of the inner partition (4) is in contact with the inner wall of the thermal insulation box (3); the height of the inner partition (4) is 7-50 cm.

7. The cell material transport device according to claim 1, characterized in that: The inner partition (4) comprises a horizontal partition, and the horizontal partition is supported by a vertical partition below; the outer sides of the horizontal partition and the vertical partition are in contact with the inner wall of the thermal insulation box (3); the horizontal partition is combined with the vertical partition to form a partition cavity below the horizontal partition; One or more concave container placement grooves are arranged above the horizontal partition.

8. The cell material transport device according to claim 7, characterized in that: The shape of the horizontal partition matches the shape of the thermal insulation box (3), which is an n3 prism shape, n3≥4; when n3=4, the length of the horizontal partition is 23 cm, the width is 12 cm, and the height of the inner partition (4) is 14 cm; when n3=5, the side length of the horizontal partition is 13 cm, and the height of the inner partition (4) is 16 cm; when n3=6, the bottom side length of the horizontal partition is 10 cm, and the height of the inner partition (4) is 16 cm.

9. The cell material transport device according to claim 7, characterized in that: The temperature regulating device (5) is arranged in the partition cavity, the volume of the temperature regulating device (5) is smaller than the volume of the partition cavity, and the surface area of ​​the temperature regulating device (5) is greater than or equal to the area of ​​the container placement groove; the surface area of ​​the temperature regulating device (5) is greater than or equal to 75 cm 2 , less than or equal to 150cm 2 ; The temperature regulating device includes a temperature increasing device and / or a temperature decreasing device; The temperature increasing device includes: one or more of a self-heating heating pack, a heat preservation bag, and a hot water bag; the temperature decreasing device includes: one or both of an ice bag and an ice tray.

10. The cell material transport device according to claim 1, characterized in that: The irreversible thermochromic material includes a protective layer, a color-changing layer, a printing layer, and an adhesive layer in order from the outside to the inside; and / or, A temperature colorimetric card is arranged outside the cell culture container (6), and the temperature colorimetric card is used to calibrate the color of the irreversible thermochromic material at different temperatures.

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