Synthesis kettle for preparing indazole ring of boritinib intermediate

Abstract

The utility model relates to the technical field of medicine preparation, in particular to a synthesis kettle for preparing a boritinib intermediate indazole ring, which not only accelerates the cooling of a solution after reaction and improves the working efficiency, but also facilitates the filtration of the cooled solution and omits the frequent transfer of the solution by workers. Comprising a synthesis kettle; the device further comprises a stirring mechanism, a heating mechanism, a water conveying mechanism and a filtering mechanism, the stirring mechanism is installed on the synthesis kettle and used for stirring raw materials, the heating mechanism is installed on the synthesis kettle and used for heating water, and the water conveying mechanism is installed on the heating mechanism and used for recycling water. And the filtering mechanism is arranged on the synthesis kettle and is used for filtering the reacted solution.

Description

Technical Field

[0001] The utility model relates to the technical field of drug preparation, in particular to a synthesis kettle for preparing a Berretinib intermediate indazole ring. Background Art

[0002] Berretinib is an important drug molecule, and its synthesis process involves a variety of complex chemical reactions and steps. In the preparation of Berretinib, the indazole ring is a key intermediate, and its synthesis plays a vital role in the preparation of the entire drug.

[0003] An existing synthesis reactor, for example, a cyclohexanecarbonyl chloride synthesis reactor disclosed in the utility model patent with application number 202220334116.9, has a main structure comprising a base, a support seat is welded and installed on the top of the base, a slide groove is provided on the top of the support seat, a motor cavity is provided at the bottom of the slide groove, a first motor is welded and installed on the inner bottom of the motor cavity, a synthesis reactor is slidably installed inside the slide groove, the output shaft of the first motor is welded and installed on the bottom of the synthesis reactor, a discharge port is provided on the front side wall of the synthesis reactor, and a groove is provided on the front side wall of the support; when in use, the first stirring rod and the second stirring rod are driven to rotate by the synthesis reactor to fully stir and react the solution inside the synthesis reactor, the first stirring rod stirs the solution deposited at the bottom of the inner side of the synthesis reactor, the rotating shaft is driven to rotate by the second motor, and the rotating shaft drives the third stirring rod to stir the solution in the synthesis reactor, and the rotation direction of the third stirring rod is opposite to that of the synthesis reactor, and the third stirring rod and the second stirring rod rotate alternately to speed up the production rate.

[0004] However, the existing synthesis kettle needs to be cooled to room temperature after the reaction is completed to obtain the product, and natural cooling wastes a lot of time. In addition, the liquid needs to be filtered after the indazole ring is successfully prepared. Most of the existing synthesis kettles still need to transfer the solution and then filter it, which is very troublesome. Utility Model Content

[0005] In order to solve the above technical problems, the utility model provides a synthesis kettle for preparing the indazole ring of the intermediate of berretinib, which not only accelerates the cooling of the solution after the reaction and improves the work efficiency, but also facilitates the filtration of the cooled solution and eliminates the need for staff to frequently transport the solution.

[0006] The utility model discloses a synthesis kettle for preparing an indazole ring of a berritinib intermediate, comprising a synthesis kettle; a stirring mechanism, a heating mechanism, a water supply mechanism and a filtering mechanism, wherein the stirring mechanism is installed on the synthesis kettle and stirs the raw materials, the heating mechanism is installed on the synthesis kettle and heats water, the water supply mechanism is installed on the heating mechanism and recycles the water, and the filtering mechanism is installed on the synthesis kettle and filters the solution after the reaction; a worker adds the raw materials into the synthesis kettle, starts the stirring mechanism to stir the raw materials, and the heating mechanism heats the water at the same time, and the water supply mechanism transports the hot water into the synthesis kettle to heat the raw materials; when the raw materials react, the heating mechanism discharges the hot water in the synthesis kettle, and the water supply mechanism transports cold water into the synthesis kettle to accelerate the cooling of the finished product; when the solution is cooled and crystallized into a solid, the solution is discharged into the filtering mechanism to filter the solution, so as to facilitate the collection of the finished product; and then the water supply mechanism rinses the synthesis kettle with cold water for cooling, so as to facilitate subsequent use.

[0007] Preferably, the synthesis reactor comprises a support, a thermal insulation layer, a heat conducting layer, a feed pipe, a delivery pipe and a valve 1, the bottom end of the support is connected to the ground, the bottom end of the thermal insulation layer is connected to the top end of the support, a cavity is arranged inside the thermal insulation layer, the heat conducting layer is installed in the cavity of the thermal insulation layer, a chamber is arranged inside the thermal conductivity layer, the bottom end of the feed pipe is connected to the top end of the thermal insulation layer and communicates with the inside of the chamber of the thermal conductivity layer, the top end of the delivery pipe is connected to the bottom end of the thermal insulation layer and communicates with the inside of the chamber of the thermal conductivity layer, and the valve 1 is installed on the delivery pipe; the raw material is added into the chamber of the thermal conductivity layer through the feed pipe, the water delivery mechanism adds hot water into the cavity of the thermal insulation layer, a constant reaction temperature is maintained inside the thermal conductivity layer through water bath heating, so that the raw material is heated more evenly, after the reaction is completed, cold water is delivered to the cavity of the thermal insulation layer through the water delivery mechanism to accelerate the cooling of the product, and after the product is cooled, the valve 1 is opened, and the product is delivered to the filtering mechanism through the delivery pipe.

[0008] Preferably, the stirring mechanism includes a motor, a reducer, a transmission shaft and a stirring rod, the bottom end of the motor is connected to the top of the insulation layer, the bottom end of the reducer is connected to the top of the insulation layer, the transmission shaft is rotatably installed in the cavity of the heat conductive layer and longitudinally connected to the reducer, and the stirring rod is installed on the transmission shaft; start the motor, the motor drives the transmission shaft to rotate through the reducer, and the transmission shaft drives the stirring rod to rotate to stir the raw materials, thereby accelerating the reaction rate of the raw materials.

[0009] Preferably, the heating mechanism comprises a heating box, an inlet pipe, a second valve, a drain pipe, a third valve, a return pipe and a fourth valve. The bottom end of the heating box is connected to the top end of the insulation layer. The inlet pipe is installed on the heating box and communicated with the interior of the heating box. The second valve is installed on the inlet pipe. The drain pipe is installed on the bottom end of the insulation layer and communicated with the interior of the cavity of the insulation layer. The third valve is installed on the drain pipe. The return pipe is installed on the heating box and communicated with the interior of the heating box and the drain pipe respectively. The fourth valve is installed on the return pipe. Close the drain pipe and the third valve, open the second valve, Connect the water inlet pipe to the external water source, and transport water to the heating box through the water inlet pipe for heating. After the reaction is completed, close valve four and the heating switch of the heating box, open valve two and valve three, and the hot water in the cavity of the insulation layer is discharged through the drain pipe. At the same time, the water inlet pipe transports cold water to the water delivery mechanism to accelerate product cooling. After the product is discharged, close valve two, valve three and the heating switch of the heating box, open valve four, and the cold water in the cavity of the insulation layer flows back to the heating box through the return pipe, which is convenient for the water delivery mechanism to clean the device.

[0010] Preferably, the water delivery mechanism includes a water pump, a water pumping pipe, a water delivery pipe 1, a valve 5, a water delivery pipe 2, a valve 6 and a nozzle. The bottom end of the water pump is connected to the top end of the thermal insulation layer and is connected to the reducer transmission. The water pumping pipe is installed on the water pump and communicated with the interior of the heating box. The water delivery pipe 1 is installed on the water pump and communicated with the interior of the cavity of the thermal insulation layer. The valve 5 is installed on the water delivery pipe 1. The water delivery pipe 2 is installed on the valve 5 and communicated with the interior of the cavity of the thermal conductive layer. The valve 6 is installed on the water delivery pipe 2. The nozzle is installed in the cavity of the thermal conductive layer and connected to the interior of the water delivery pipe 2. The reducer drives the water pump to pump water, and the water pump pumps out the hot water in the heating box through the pumping pipe, closes valve six and opens valve five, and the water pump transports the hot water through the water pipe one to the cavity of the thermal insulation layer to heat the thermal conductive layer. After the reaction is completed, cold water is transported to the cavity of the thermal insulation layer to accelerate the cooling of the product. After the product is discharged from the cavity of the thermal conductive layer, close valve five and open valve six, and the water pump transports the cold water to the nozzle through the water pipe two, and sprays the nozzle into the cavity of the thermal conductive layer for cleaning, which is convenient for subsequent use.

[0011] Preferably, the filtering mechanism includes a filter box, a discharge pipe, a valve seven, a filter drawer and a pull ring. The filter box is installed on a bracket and is connected to the interior of the feed pipe. The top end of the discharge pipe is connected to the bottom end of the filter box. The valve seven is installed on the discharge pipe. The filter drawer is slidably installed on the filter box, and the pull ring is installed on the filter drawer. The product is transported to the filter box and filtered by the filter drawer. The crystals in the product solution remain on the filter drawer. The valve seven is opened and the solution is discharged through the discharge pipe. When all filtering is completed, the staff pulls out the filter drawer through the pull ring to collect the crystal product.

[0012] Compared with the prior art, the utility model has the following beneficial effects: a worker adds raw materials into a synthesis kettle, starts a stirring mechanism to stir the raw materials, and at the same time a heating mechanism heats water, and a water delivery mechanism delivers hot water into the synthesis kettle to heat the raw materials; after the reaction of the raw materials is completed, the heating mechanism discharges the hot water in the synthesis kettle, and the water delivery mechanism delivers cold water into the synthesis kettle to accelerate the cooling of the finished product; after the solution is cooled and crystallized into a solid, the solution is discharged into a filtering mechanism to filter the solution, which is convenient for collecting the finished product; and then the water delivery mechanism uses the cold water for cooling to rinse the synthesis kettle, which is convenient for subsequent use. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a schematic diagram of the axonometric structure of the utility model;

[0014] Figure 2 It is a schematic diagram of the cross-section axonometric structure of the synthesis kettle, stirring mechanism and water delivery mechanism of the utility model;

[0015] Figure 3 It is a partially enlarged isometric structural diagram of the heating mechanism of the utility model;

[0016] Figure 4 It is a partially enlarged axonometric structural diagram of the water delivery mechanism of the utility model;

[0017] Figure 5 It is a partially enlarged axonometric structural schematic diagram of the filtering mechanism of the utility model.

[0018] Markings in the attached drawings: 01, synthesis kettle; 11, bracket; 12, insulation layer; 13, heat conductive layer; 14, feed pipe; 15, delivery pipe; 16, valve one; 02, stirring mechanism; 21, motor; 22, reducer; 23, transmission shaft; 24, stirring rod; 03, heating mechanism; 31, heating box; 32, water inlet pipe; 33, valve two; 34, drain pipe; 35, valve three; 36, return pipe; 37, valve four; 04, water delivery mechanism; 41, water pump; 42, water suction pipe; 43, water delivery pipe one; 44, valve five; 45, water delivery pipe two; 46, valve six; 47, nozzle; 05, filtering mechanism; 51, filter box; 52, discharge pipe; 53, valve seven; 54, filter drawer; 55, pull ring. DETAILED DESCRIPTION

[0019] In order to facilitate the understanding of the utility model, the utility model will be described more comprehensively below with reference to the relevant drawings. The utility model can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the utility model more thorough and comprehensive.

[0020] Example 1

[0021] The utility model discloses a synthesis kettle for preparing an indazole ring of a berretinib intermediate, comprising a synthesis kettle 01; further comprising a stirring mechanism 02, a heating mechanism 03, a water supply mechanism 04 and a filtering mechanism 05, wherein the stirring mechanism 02 is installed on the synthesis kettle 01 and stirs the raw materials, the heating mechanism 03 is installed on the synthesis kettle 01 and heats the water, the water supply mechanism 04 is installed on the heating mechanism 03 and recycles the water, and the filtering mechanism 05 is installed on the synthesis kettle 01 and filters the solution after the reaction; the synthesis kettle 01 comprises a bracket 11, a heat-insulating layer 12, a heat-conducting layer 13, a feed pipe 14, a feed pipe 15 and a valve 16, the bottom end of the bracket 11 is connected to the ground, the bottom end of the heat-insulating layer 12 is connected to the bracket 11, and the bottom end of the heat-insulating layer 12 is connected to the bracket 11. The top of the frame 11 is connected, the interior of the thermal insulation layer 12 is provided with a cavity, the heat-conducting layer 13 is installed in the cavity of the thermal insulation layer 12, the interior of the heat-conducting layer 13 is provided with a chamber, the bottom end of the feed pipe 14 is connected to the top of the thermal insulation layer 12 and communicates with the interior of the chamber of the heat-conducting layer 13, the top of the delivery pipe 15 is connected to the bottom of the thermal insulation layer 12 and communicates with the interior of the chamber of the heat-conducting layer 13, and a valve 16 is installed on the delivery pipe 15; the stirring mechanism 02 includes a motor 21, a reducer 22, a transmission shaft 23 and a stirring rod 24, the bottom end of the motor 21 is connected to the top of the thermal insulation layer 12, the bottom end of the reducer 22 is connected to the top of the thermal insulation layer 12, the transmission shaft 23 is rotatably installed in the chamber of the heat-conducting layer 13 and It is longitudinally connected to the reducer 22, and the stirring rod 24 is installed on the transmission shaft 23; the heating mechanism 03 includes a heating box 31, an inlet pipe 32, a valve two 33, a drain pipe 34, a valve three 35, a return pipe 36 and a valve four 37. The bottom end of the heating box 31 is connected to the top of the insulation layer 12, the inlet pipe 32 is installed on the heating box 31 and communicates with the inside of the heating box 31, the valve two 33 is installed on the inlet pipe 32, the drain pipe 34 is installed at the bottom of the insulation layer 12 and communicates with the cavity inside the insulation layer 12, the valve three 35 is installed on the drain pipe 34, the return pipe 36 is installed on the heating box 31 and communicates with the inside of the heating box 31 and the drain pipe 34 respectively, and the valve four 37 is installed on the return pipe 3 6; the water delivery mechanism 04 includes a water pump 41, a water extraction pipe 42, a water delivery pipe 1 43, a valve 5 44, a water delivery pipe 2 45, a valve 6 46 and a nozzle 47, the bottom end of the water pump 41 is connected to the top of the thermal insulation layer 12, and is in transmission connection with the reducer 22, the water extraction pipe 42 is installed on the water pump 41 and communicated with the interior of the heating box 31, the water delivery pipe 1 43 is installed on the water pump 41 and communicated with the interior of the cavity of the thermal insulation layer 12, the valve 5 44 is installed on the water delivery pipe 1 43, the water delivery pipe 2 45 is installed on the valve 5 44 and communicated with the interior of the chamber of the thermal conductive layer 13, the valve 6 46 is installed on the water delivery pipe 2 45, and the nozzle 47 is installed in the chamber of the thermal conductive layer 13 and communicated with the interior of the water delivery pipe 2 45;When it is working, firstly, the raw materials are added into the chamber of the heat-conducting layer 13 through the feed pipe 14, the motor 21 is started, the motor 21 drives the transmission shaft 23 to rotate through the reducer 22, the transmission shaft 23 drives the stirring rod 24 to rotate to stir the raw materials, and accelerate the reaction rate of the raw materials. At the same time, the drain pipe 34 and the valve three 35 are closed, the valve two 33 is opened, the water inlet pipe 32 is connected to the external water source, and the water is transported to the heating box 31 through the water inlet pipe 32 for heating. The reducer 22 drives the water pump 41 to pump water, and the water pump 41 pumps the hot water in the heating box 31 through the pumping pipe 42, the valve six 46 is closed and the valve five 44 is opened, and the water pump 41 transports the hot water through the water pipe one 43 to the cavity of the thermal insulation layer 12 to heat the heat-conducting layer 13. After the reaction is completed, close valve 4 37 and the heating switch of the heating box 31, open valve 2 33 and valve 3 35, the hot water in the cavity of the insulation layer 12 is discharged through the drain pipe 34, and the cold water is transported to the cavity of the insulation layer 12 to accelerate the cooling of the product. After the product is cooled, open valve 16, and the product is transported to the filter mechanism 05 through the feed pipe 15, then close valve 2 33, valve 3 35 and the heating switch of the heating box 31, open valve 4 37, the cold water in the cavity of the insulation layer 12 flows back to the heating box 31 through the return pipe 36, close valve 5 44 and open valve 6 46, the water pump 41 transports the cold water to the nozzle 47 through the water pipe 2 45, and the nozzle 47 is sprayed into the cavity of the heat-conducting layer 13 for cleaning, which is convenient for subsequent use. ;

[0022] Example 2

[0023] like Figures 1 to 5As shown, a synthesis reactor for preparing the indazole ring of a berritinib intermediate of the utility model is based on Example 1; the filtering mechanism 05 includes a filter box 51, a discharge pipe 52, a valve 53, a filter drawer 54 and a pull ring 55, the filter box 51 is installed on the bracket 11 and is connected to the inside of the feed pipe 15, the top of the discharge pipe 52 is connected to the bottom of the filter box 51, the valve 53 is installed on the discharge pipe 52, the filter drawer 54 is slidably installed on the filter box 51, and the pull ring 55 is installed on the filter drawer 54; when it is working, the raw material is first fed through the feed pipe 14 Add it into the chamber of the heat conductive layer 13, start the motor 21, the motor 21 drives the transmission shaft 23 to rotate through the reducer 22, the transmission shaft 23 drives the stirring rod 24 to rotate to stir the raw materials, accelerate the reaction rate of the raw materials, and at the same time close the drain pipe 34 and the valve three 35, open the valve two 33, connect the water inlet pipe 32 with the external water source, and transport water to the heating box 31 through the water inlet pipe 32 for heating. The reducer 22 drives the water pump 41 to pump water, and the water pump 41 pumps the hot water in the heating box 31 through the pumping pipe 42, close the valve six 46, open the valve five 44, and the water pump 41 conveys hot water to the cavity of the thermal insulation layer 12 through the water delivery pipe 1 43 to heat the thermal conductive layer 13. After the reaction is completed, close the valve 4 37 and the heating switch of the heating box 31, open the valve 2 33 and the valve 3 35, and the hot water in the cavity of the thermal insulation layer 12 is discharged through the drain pipe 34. 4 conveys cold water to the cavity of the thermal insulation layer 12 to accelerate the cooling of the product. After the product is cooled, open the valve 16, and the product is conveyed to the filter box 51 through the feed pipe 15 and filtered by the filter drawer 54. The crystals in the product solution remain on the filter drawer 54. , open valve seven 53, the solution is discharged through the discharge pipe 52. When all the filtration is completed, the staff pulls out the filter drawer 54 through the pull ring 55 to collect the crystal product, and then closes valve two 33, valve three 35 and the heating switch of the heating box 31, opens valve four 37, and the cold water in the cavity of the insulation layer 12 flows back to the heating box 31 through the return pipe 36, closes valve five 44 and opens valve six 46, and the water pump 41 transports the cold water to the nozzle 47 through the water pipe two 45, and sprays the nozzle 47 into the chamber of the heat conductive layer 13 for cleaning, which is convenient for subsequent use.

[0024] The motor 21, the reducer 22 and the water pump 41 of the utility model are purchased on the market, and the technicians in the industry only need to install and operate them according to the accompanying instruction manuals, without the need for the technicians in the field to make creative efforts.

[0025] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principle of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A synthesis reactor for preparing the indazole ring of a Berretinib intermediate, comprising a synthesis reactor (01); characterized in that: The invention also comprises a stirring mechanism (02), a heating mechanism (03), a water supply mechanism (04) and a filtering mechanism (05). The stirring mechanism (02) is installed on the synthesis kettle (01) and stirs the raw materials. The heating mechanism (03) is installed on the synthesis kettle (01) and heats the water. The water supply mechanism (04) is installed on the heating mechanism (03) and recycles the water. The filtering mechanism (05) is installed on the synthesis kettle (01) and filters the solution after the reaction.

2. A synthesis reactor for preparing the indazole ring of a berretinib intermediate according to claim 1, characterized in that: The synthesis reactor (01) comprises a support (11), a thermal insulation layer (12), a heat-conducting layer (13), a feed pipe (14), a delivery pipe (15) and a valve (16). The bottom end of the support (11) is connected to the ground, the bottom end of the thermal insulation layer (12) is connected to the top end of the support (11), a cavity is arranged inside the thermal insulation layer (12), the heat-conducting layer (13) is installed in the cavity of the thermal insulation layer (12), a chamber is arranged inside the heat-conducting layer (13), the bottom end of the feed pipe (14) is connected to the top end of the thermal insulation layer (12) and communicates with the inside of the chamber of the heat-conducting layer (13), the top end of the delivery pipe (15) is connected to the bottom end of the thermal insulation layer (12) and communicates with the inside of the chamber of the heat-conducting layer (13), and the valve (16) is installed on the delivery pipe (15).

3. A synthesis reactor for preparing the indazole ring of a berretinib intermediate as claimed in claim 2, characterized in that: The stirring mechanism (02) comprises a motor (21), a reducer (22), a transmission shaft (23) and a stirring rod (24); the bottom end of the motor (21) is connected to the top end of the thermal insulation layer (12); the bottom end of the reducer (22) is connected to the top end of the thermal insulation layer (12); the transmission shaft (23) is rotatably mounted in the chamber of the heat-conducting layer (13) and longitudinally connected to the reducer (22); and the stirring rod (24) is mounted on the transmission shaft (23).

4. A synthesis reactor for preparing the indazole ring of a berretinib intermediate as claimed in claim 2, characterized in that: The heating mechanism (03) comprises a heating box (31), a water inlet pipe (32), a second valve (33), a drainage pipe (34), a third valve (35), a return pipe (36) and a fourth valve (37). The bottom end of the heating box (31) is connected to the top end of the thermal insulation layer (12). The water inlet pipe (32) is mounted on the heating box (31) and communicates with the interior of the heating box (31). The second valve (33) is mounted on the water inlet pipe (32). The drainage pipe (34) is mounted on the bottom end of the thermal insulation layer (12) and communicates with the interior of the cavity of the thermal insulation layer (12). The third valve (35) is mounted on the drainage pipe (34). The return pipe (36) is mounted on the heating box (31) and communicates with the interior of the heating box (31) and the drainage pipe (34) respectively. The fourth valve (37) is mounted on the return pipe (36).

5. A synthesis reactor for preparing the indazole ring of a berretinib intermediate as claimed in claim 4, characterized in that: The water delivery mechanism (04) comprises a water pump (41), a water extraction pipe (42), a water delivery pipe 1 (43), a valve 5 (44), a water delivery pipe 2 (45), a valve 6 (46) and a nozzle (47). The bottom end of the water pump (41) is connected to the top end of the thermal insulation layer (12) and is transmission-connected to the reducer (22). The water extraction pipe (42) is mounted on the water pump (41) and is in communication with the interior of the heating box (31). The water delivery pipe 1 (43) is mounted on the water pump (41) and is in communication with the interior of the cavity of the thermal insulation layer (12). The valve 5 (44) is mounted on the water delivery pipe 1 (43). The water delivery pipe 2 (45) is mounted on the valve 5 (44) and is in communication with the interior of the cavity of the thermal conductive layer (13). The valve 6 (46) is mounted on the water delivery pipe 2 (45). The nozzle (47) is mounted in the cavity of the thermal conductive layer (13) and is in communication with the interior of the water delivery pipe 2 (45).

6. A synthesis reactor for preparing the indazole ring of a berretinib intermediate as claimed in claim 2, characterized in that: The filtering mechanism (05) comprises a filtering box (51), a discharge pipe (52), a valve (53), a filtering drawer (54) and a pull ring (55); the filtering box (51) is mounted on a bracket (11) and is connected to the interior of a feeding pipe (15); the top end of the discharge pipe (52) is connected to the interior of a bottom end of the filtering box (51); the valve (53) is mounted on the discharge pipe (52); the filtering drawer (54) is slidably mounted on the filtering box (51); and the pull ring (55) is mounted on the filtering drawer (54).

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