Immunohistochemical pen

Abstract

The utility model relates to an immunohistochemical pen which comprises a pen point part and a pen head part, a cylindrical plug, a confining liquid guide pipe and a replaceable edge sealing liquid bag are arranged through the pen point part, the replaceable edge sealing liquid bag is movably connected with the cylindrical plug in a clamped mode, the confining liquid guide pipe enters the replaceable edge sealing liquid bag, and therefore confining liquid replacement and repeated use of the immunohistochemical pen are achieved. The blocking connecting column is attached to the inner wall of the replaceable edge sealing liquid bag in a sliding mode, the cylindrical blocking block is movably connected with the clamping groove in a clamped mode, and the situation that connection between the replaceable edge sealing liquid bag and the pen point part is not stable can be prevented. The replaceable edge sealing liquid bag is made of a flexible material, and the squeezing part is arranged on the side wall of the pen holder part, so that the liquid outlet speed and the liquid outlet capacity can be controlled during use.

Description

Technical Field

[0001] The utility model relates to the field of immune combination experimental tools, in particular to an immunohistochemistry pen. Background Art

[0002] The immunohistochemical pen is also called PapPen, and the immunohistochemical PAP pen is used in experiments such as immunohistochemical staining, immunofluorescence staining, in situ hybridization, and special staining. It is suitable for various immunohistochemical staining experiments of glass slices, such as PAP method, ABC method, immunofluorescence method, frozen section and in situ hybridization technology, which can reduce the amount of antibodies and reagents and avoid the flow and diffusion of liquid during staining. The existing immunohistochemical pen structure is a sealed pen barrel, and the pen head design adopts a foam pen head. Therefore, the internal sealing liquid cannot be replaced, and the consumption is high. And during use, the liquid in the pen on the foam pen head will often evaporate due to the long interval of use. The liquid in the pen can only flow to the foam pen head by pressing the pen head hard to make the air in the pen barrel discharge. When the force is not appropriate, the liquid in the pen will flow out in large quantities, causing the loss of sealing liquid and contamination of the slice. Summary of the invention

[0003] The utility model aims to provide a novel immunohistochemistry pen which can replace the sealing liquid, can be reused, and can control the liquid discharge speed and liquid discharge volume.

[0004] In order to achieve the purpose of the utility model, the solution to the technology is as follows:

[0005] An immunohistochemistry pen comprises a pen tip and a pen head, wherein: the pen tip comprises a cylindrical body and a truncated cone body with openings at both ends, the end face of the truncated cone body with a larger diameter is fixedly connected to the bottom end of the cylindrical body through a circular ring support sheet; inside the cylindrical body, a cylindrical block is fixedly connected to the upper surface of the circular ring support sheet, and the inside of the cylindrical block is hollow; a sealing liquid guide tube is fixedly connected to both ends of the cylindrical block, and each sealing liquid guide tube is connected to the inside of the cylindrical block; the pen head can be inserted and removed from the end face of the truncated cone body with a smaller diameter, and contacts the sealing liquid guide tube located at the bottom end of the cylindrical block.

[0006] Furthermore, the immunohistochemistry pen also includes a replaceable sealing liquid capsule, which is filled with sealing liquid for sealing. A snap-in groove is opened at one end of the replaceable sealing liquid capsule, and the snap-in groove is movably snap-connected with the top end of the cylindrical blockage. The sealing liquid guide tube located at the top end of the cylindrical blockage extends into the replaceable sealing liquid capsule.

[0007] Furthermore, inside the cylindrical body, a blocking connecting column is fixedly connected to the upper surface of the annular support sheet, and the blocking connecting column is hollow and sleeved outside the cylindrical blocker.

[0008] Furthermore, the diameter of the blocking connecting column is larger than the diameter of the replaceable edge-sealing liquid capsule and the cylindrical blocking diameter, and the height of the blocking connecting column is larger than the cylindrical blocking height.

[0009] Furthermore, a groove is provided at the top of the pen head, and the groove is sleeved on the bottom end of the sealing liquid guide tube located at the bottom end of the cylindrical blocking body.

[0010] Furthermore, the central axes of the closed liquid guide tube, the cylindrical block, the blocking connecting column and the cylindrical body, the frustum body and the annular support sheet are located in the same straight line.

[0011] Furthermore, the immunohistochemistry pen also includes a pen shaft with a cavity inside, the top of the pen shaft is closed, the bottom end is open and connected to the internal cavity; the top of the outer wall of the cylindrical body is provided with a thread, and the bottom of the inner wall of the pen shaft cavity is provided with a thread that matches the thread on the cylindrical body.

[0012] Furthermore, the replaceable edge-sealing liquid capsule is made of flexible plastic; an extrusion portion is also provided on the side wall of the pen body, located in the cavity, and the extrusion portion is made of flexible plastic.

[0013] Compared with the prior art, the utility model has the following significant advantages:

[0014] 1. The pen tip is provided with a cylindrical block, a sealing liquid guide tube, and a replaceable edge sealing liquid capsule. The replaceable edge sealing liquid capsule is movably connected with the cylindrical block, and the sealing liquid guide tube enters the replaceable edge sealing liquid capsule to replace the sealing liquid and reuse the tissue pen;

[0015] 2. By blocking the connection column from sliding against the inner wall of the replaceable edge-sealing liquid capsule, the cylindrical blocker is movably connected with the snap-in groove, which can prevent the replaceable edge-sealing liquid capsule from being unstable in connection with the pen tip;

[0016] 3. The setting of the blocking connecting column can prevent the operator from overflowing the edge sealing liquid from the replaceable edge sealing liquid capsule during the use of the composition pen;

[0017] 4. The replaceable edge sealing liquid capsule is made of flexible material, and the extrusion part is arranged on the side wall of the pen body. When in use, the liquid discharge speed and liquid discharge capacity can be controlled. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a cross-sectional view of the pen tip and the pen head of the utility model.

[0019] Figure 2 It is a schematic diagram of the structure of the replacement edge sealing liquid capsule of the utility model.

[0020] Figure 3 It is a schematic diagram of the overall structure of the utility model.

[0021] In the figure, 1 is a cylindrical body, 2 is a truncated cone body, 3 is a pen head, 4 is a replaceable edge sealing liquid capsule, 5 is a pen shaft, 11 is a circular ring support sheet, 12 is a blocking connecting column, 13 is a cylindrical blockage, 14 is a sealing liquid guide tube, 31 is a groove, 41 is a snap-on groove, and 51 is an extrusion portion. DETAILED DESCRIPTION

[0022] The following is combined with Figure 1-3 , describe the implementation mode of the utility model in detail.

[0023] An immunohistochemistry pen includes a pen tip and a pen head 3. The pen tip has two parts, a cylindrical body 1 and a truncated cone body 2, which are open at both ends. The end surface of the truncated cone body 2 with a larger diameter is fixedly connected to the bottom end of the cylindrical body 1 through a circular support sheet 11. Inside the cylindrical body 1, a cylindrical blockage 13 is fixedly connected to the upper surface of the circular support sheet 11, and the cylindrical blockage 13 is hollow inside; a sealing liquid guide tube 14 is fixedly connected to both ends of the cylindrical blockage 13, and each sealing liquid guide tube 14 is connected to the inside of the cylindrical blockage 13. Figure 1 As shown, one end of the sealing liquid guide tube 14 is located inside the truncated cone cylinder 2.

[0024] In the cylindrical body 2, a blocking connecting column 12 is fixedly connected to the upper surface of the annular support sheet. The blocking connecting column 12 is hollow and sleeved outside the cylindrical block 13. The height of the blocking connecting column is greater than the height of the cylindrical block. The central axis of the sealing liquid guide tube 14, the cylindrical block 13, the blocking connecting column 12, the cylindrical body 1, the truncated cone body 2, and the annular support sheet 11 are located in the same straight line.

[0025] The pen head 3 can be plugged in and out, and a foam cotton pen head is inserted into the inside of the truncated cone body 2 from the end face with a small diameter of the truncated cone body 2, and contacts the sealing liquid guide tube 14 located at the bottom end of the cylindrical obstruction 13. Further, a groove 31 is provided at the top of the pen head 3, and the groove 31 is sleeved on the bottom end of the sealing liquid guide tube 14 located at the bottom end of the cylindrical obstruction 13. The groove 31 can increase the contact area between the pen head and the sealing liquid, thereby facilitating the outflow of the sealing liquid.

[0026] like Figure 2As shown, the immunohistochemistry pen also includes a replaceable edge-sealing liquid capsule 4, which contains an edge-sealing liquid for edge sealing, preferably a low-melting-point high-purity liquid paraffin. The diameter of the blocking connecting column 12 is larger than the diameter of the replaceable edge-sealing liquid capsule 4. The replaceable edge-sealing liquid capsule 4 is slidably engaged with the inner wall of the blocking connecting column 12. A snap-in groove 41 is provided at the top of the replaceable edge-sealing liquid capsule 4, and the snap-in groove 41 is movably engaged with the top of the cylindrical blocking 13. In order to allow the sealing liquid guide tube 14 to pierce the concave surface of the snap-in groove 41, the edge-sealing liquid enters the sealing liquid guide tube 14 and then flows to the pen head 3, and the concave wall of the snap-in groove 41 is thin. Further, a through surface can be provided at the center of the concave axis of the snap-in groove 41, and the wall on the through surface is thin, so as to achieve the purpose of piercing the sealing liquid guide tube 14. When in use, the replaceable edge-sealing liquid capsule 4 is snapped on the cylindrical blocking 13, and the sealing liquid guide tube 14 located at the top of the cylindrical blocking 13 extends into the replaceable edge-sealing liquid capsule 4.

[0027] The immunohistochemistry pen also includes a pen shaft 5 with a cavity inside, the top of the pen shaft is closed, the bottom is open, and communicates with the internal cavity. A thread is provided on the bottom of the inner wall of the cavity of the pen shaft 5. Correspondingly, the diameter of the cylindrical body 1 is slightly smaller than the diameter of the bottom end of the pen shaft, and a thread is provided on the top of the outer wall of the cylindrical body 1, which is adapted to the thread on the cavity wall of the pen shaft 5. The pen shaft cavity accommodates a replaceable edge-sealing liquid capsule 4.

[0028] The replaceable edge sealing liquid capsule 4 is made of flexible plastic for easy squeezing. Two squeezing parts 51 are also provided on the side wall of the pen shaft 5 at the cavity, and the squeezing parts 51 are made of flexible plastic. When in use, the squeezing parts 51 are squeezed on the replaceable edge sealing liquid capsule 4, and the internal edge sealing liquid flows into the sealing liquid guide tube 14, and flows into the pen head 3 along the sealing liquid guide tube 14.

[0029] By making the blocking connecting column 12 slide and fit with the inner wall of the replaceable edge-sealing liquid capsule 4, and the cylindrical blocking 13 and the engaging groove 41 movably engage with each other, it is possible to prevent the replaceable edge-sealing liquid capsule 4 from being unstable in connection with the pen tip. In addition, the setting of the blocking connecting column 12 can prevent the operator from overflowing the edge-sealing liquid from the replaceable edge-sealing liquid capsule 4 during the use of the composition pen. If the edge-sealing liquid overflows and flows into the entire cylindrical body 1, it will not only waste consumables, but the viscosity of the edge-sealing liquid will also cause the matching threads to stick together and cannot be opened.

[0030] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. An immunohistochemistry pen, comprising a pen tip and a pen head (3), characterized in that: The pen tip portion comprises a cylindrical body (1) with openings at both ends and a truncated cone body (2), wherein the end surface of the truncated cone body (2) with a larger diameter is fixedly connected to the bottom end of the cylindrical body (1) via a circular ring support sheet (11); a cylindrical block (13) is fixedly connected to the upper surface of the circular ring support sheet in the cylindrical body (1), and the cylindrical block (13) is hollow inside; a sealing liquid guide tube (14) is fixedly connected to both ends of the cylindrical block (13), and each sealing liquid guide tube (14) is communicated with the inside of the cylindrical block (13); The pen head (3) can be inserted and removed from the end surface of the truncated cone body (2) with a small diameter and is inserted into the interior of the truncated cone body (2) and is in contact with a sealing liquid guide tube (14) located at the bottom end of the cylindrical block (13).

2. The immunohistochemistry pen according to claim 1, characterized in that: The immunohistochemistry pen also includes a replaceable edge-sealing liquid capsule (4), which contains edge-sealing liquid for edge sealing. A snap-in groove (41) is provided at one end of the replaceable edge-sealing liquid capsule (4), and the snap-in groove (41) is movably snap-connected with the top end of the cylindrical blocker (13). A sealing liquid guide tube (14) located at the top end of the cylindrical blocker (13) extends into the replaceable edge-sealing liquid capsule (4).

3. The immunohistochemistry pen according to claim 2, characterized in that: Inside the cylindrical body (1), a blocking connection column (12) is fixedly connected to the upper surface of the annular support sheet. The blocking connection column (12) is hollow and sleeved outside the cylindrical blocker (13).

4. The immunohistochemistry pen according to claim 3, characterized in that: The diameter of the blocking connection column (12) is larger than the diameter of the replaceable edge sealing liquid capsule (4) and the cylindrical blockage (13), and the height of the blocking connection column is larger than the height of the cylindrical blockage (13).

5. The immunohistochemistry pen according to claim 2, characterized in that: A groove (31) is provided at the top of the pen head (3), and the groove (31) is sleeved on the bottom end of a sealing liquid guide tube (14) located at the bottom end of the cylindrical blocker (13).

6. The immunohistochemistry pen according to claim 1, characterized in that: The central axes of the sealing liquid guide tube (14), the cylindrical blocking (13), the blocking connecting column (12), the cylindrical body (1), the frustum body (2), and the annular support sheet (11) are located in the same straight line.

7. The immunohistochemistry pen according to claim 2, characterized in that: The immunohistochemistry pen also includes a pen shaft (5) with an internal cavity, wherein the pen shaft (5) is closed at the top and open at the bottom and communicates with the internal cavity; a thread is provided at the top of the outer wall of the cylindrical body (1), and a thread matching the thread on the cylindrical body (1) is provided at the bottom of the inner wall of the pen shaft (5) cavity.

8. The immunohistochemistry pen according to claim 7, characterized in that: The replaceable edge-sealing liquid capsule (4) is made of flexible plastic; an extrusion portion (51) is also provided on the side wall of the pen holder (5) at the cavity, and the extrusion portion (51) is made of flexible plastic.

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