Negative pressure suction filtration device and chemical synthesis workstation

Abstract

The utility model discloses a negative pressure suction filtration device and a chemical synthesis workstation, and relates to the technical field of chemical synthesis, the chemical synthesis workstation comprises a base, the base is provided with a negative pressure suction filtration device, a moving assembly, a pipetting head, a liquid storage assembly and a reaction zone, the moving assembly is provided with a pipetting assembly, and the movement of the pipetting assembly is controlled by the moving assembly. The pipetting assembly is used for pipetting, negative pressure suction filtration is carried out through the negative pressure suction filtration device after pipetting is finished, the suction filtration device comprises a suction filtration module, the suction filtration module comprises a negative pressure assembly, a receiving plate and a filtration module are arranged in the negative pressure assembly, and the filtration module is located above the receiving plate. According to the technical scheme, the moving assembly can drive the pipetting assembly to move, the working steps of pipetting, mixing, suction filtration and the like are completed in a full-automatic mode, efficiency is greatly improved, and meanwhile manpower is saved.

Description

Technical Field

[0001] The utility model relates to the technical field of chemical synthesis, in particular to a negative pressure filtration device and a chemical synthesis workstation. Background Art

[0002] High-throughput chemical synthesis is a method for efficient, rapid, and high-yield chemical synthesis. It uses automated laboratories and high-throughput laboratories to process thousands of different reaction species at the same time, greatly improving the yield and rate of compounds. This method has been widely used in many fields such as medicine, materials science, chemical biology, and organic chemistry, accelerating the research and development process of new materials or new drugs. Compared with traditional manual synthesis methods, high-throughput synthesis has the characteristics of higher automation, standardization, and no need for multiple people to operate, reducing the cost and risk of chemical experiments.

[0003] A Chinese invention patent with application publication number CN114410427A discloses a large-volume fully automatic nucleic acid extraction method and device, which adopts an optimized division of labor method and structural layout combining a pipetting workstation and a magnetic rod sleeve, and can complete fully automatic high-throughput large-volume nucleic acid extraction. This process has a high degree of automation, large throughput, and high efficiency, and less nucleic acid loss for mixed testing of multiple samples, ensuring detection sensitivity. A closed independent mode is adopted, and each independent space is provided with a bottom side suction filter device, so that a high negative pressure is formed at the bottom of the space. Compared with the existing top filtration method, combined with gravity, the aerosol generated by the nucleic acid extraction of the bottom device of the space can be effectively and quickly removed. Although the prior art can independently filter, it does not disclose how to collect the solution after the filtration, and setting up multiple independent spaces is not convenient for collection, so if the subsequent collection steps are not handled properly, it is easy to cause cross contamination. Utility Model Content

[0004] In view of the above technical problems, the utility model discloses a negative pressure filtration device, including a filtration module, the filtration module including a negative pressure component, a receiving plate and a filter module installed in the negative pressure component, and the filter module is located on the upper side of the receiving plate. Through the above technical solution, the moving component can drive the liquid transfer component to move, and the working steps such as liquid transfer, mixing, and filtration are completed automatically, which greatly improves efficiency and saves manpower.

[0005] Furthermore, the filtration module includes a filter seat, in which a plurality of filter tubes are arranged, each filter tube is provided with a capillary tube at the bottom, and a filter filler is arranged between the capillary tube and the filter tube. Through the above technical solution, different reaction solutions can be packaged to ensure that they will not contaminate each other, and at the same time, the filter filler can be used for filtering, so that the precipitation that may be produced by the reaction or the added solid residue will not be drawn downward, thereby ensuring the quality of the filtered solution.

[0006] Furthermore, the receiving plate includes a receiving seat, on which a plurality of receiving tubes are arranged, and the upper end surface of the receiving seat is provided with a first label and a second label, and the directions of the first label and the second label are perpendicular to each other, and are used to mark the position of each receiving tube. Through the above technical solution, each different receiving tube can be accurately named and marked, which is convenient for description and placement.

[0007] Furthermore, the negative pressure assembly comprises a lower assembly block, a receiving seat is installed in the lower assembly block, an upper assembly block is installed on the upper side of the lower assembly block, and a cover plate is installed on the upper side of the upper assembly block.

[0008] Furthermore, a first positioning ring is provided on the lower side of the cover plate, and a second inclined surface is provided on the upper end of the upper assembly block, and the second inclined surface cooperates with the first positioning ring to determine the positions of the cover plate and the upper assembly block.

[0009] Furthermore, a first sealing strip is provided in the upper assembly block, a first inclined surface is provided in the cover plate, and the lower end of the filter seat contacts the first sealing strip for sealing. Through the above technical solution, the cover plate and the filter module can be placed in the corresponding position more accurately, and at the same time, a better sealing effect can be achieved, and the pressure difference between the upper and lower parts of the first sealing strip can be larger, so that the negative pressure filtration efficiency is higher.

[0010] Furthermore, a third inclined surface is provided in the lower assembly block, the receiving seat contacts the lower assembly block through the third inclined surface, a ventilation groove is provided in the lower assembly block, a ventilation hole is provided on the receiving seat, and the receiving seat is placed on the receiving seat.

[0011] Furthermore, a positioning seat is fixedly mounted on the lower side of the receiving seat, and four positioning blocks are arranged on the upper end of the receiving seat, which are located at the four corners of the receiving seat, and the positioning seat is clamped in the positioning blocks.

[0012] Furthermore, a second magnet is disposed on the upper side of the lower assembly block, and a first magnet is disposed on the lower end of the upper assembly block, and the two are fixed to each other by magnetic force.

[0013] Furthermore, the utility model discloses a chemical synthesis workstation, including a base, the filtration module is installed on the base through a cushion seat, the base is equipped with a moving component, a pipetting head, a liquid storage component, and a reaction area, and the moving component is equipped with a pipetting component.

[0014] The beneficial effects of the utility model compared with the prior art are:

[0015] (1) Through the technical solution of the utility model, the mobile component can drive the pipetting component to move, and the pipetting, mixing, filtration and other working steps are completed fully automatically, which greatly improves the efficiency and saves manpower.

[0016] (2) Through the technical solution of the utility model, different reaction solutions can be packaged to ensure that they will not contaminate each other. At the same time, they can be filtered through filter fillers so that the precipitation that may be produced by the reaction or the added solid residue will not be drawn downward, thereby ensuring the quality of the filtered solution.

[0017] (3) Through the technical solution of the utility model, each different receiving tube can be accurately named and labeled, which is convenient for description and placement.

[0018] (4) Through the technical solution of the utility model, the cover plate and the filter module can be placed in the corresponding position more accurately, and at the same time, a better sealing effect can be achieved, and the pressure difference between the upper and lower parts of the first sealing strip can be larger, so that the negative pressure filtration efficiency is higher. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application.

[0020] Figure 2 This is a schematic diagram of a filtration module according to an embodiment of the present application.

[0021] Figure 3 Schematic diagram of a negative pressure assembly according to an embodiment of the present application.

[0022] Figure 4 The negative pressure assembly of the embodiment of the present application explodes Figure 1 .

[0023] Figure 5 The negative pressure assembly of the embodiment of the present application explodes Figure 2 .

[0024] Figure 6 This is a schematic diagram of the internal structure of the negative pressure component of an embodiment of the present application.

[0025] Figure 7 This is a schematic diagram of the receiving board structure of an embodiment of the present application.

[0026] Figure 8 It is a side view of the filter module according to an embodiment of the present application.

[0027] Fig. 9 for Figure 8 Cross-sectional view at AA in the middle.

[0028] Figure numbers: 1- filtration module; 2- base; 3- moving component; 4- pipetting component; 5- pipetting head; 6- liquid storage component; 7- reaction zone; 8- ventilation pipe; 101- receiving plate; 102- filtration module; 103- negative pressure component; 1011- receiving seat; 1012- positioning seat; 1013- receiving tube; 1014- first number; 1015- second number; 1021- filter seat; 1022- filter tube; 1023- filter filler; 1024- capillary; 1031- cover plate; 1032- first Inclined surface; 1033-first positioning ring; 1034-upper assembly block; 1035-second inclined surface; 1036-first sealing strip; 1037-second positioning ring; 1038-second sealing strip; 1039-first magnet; 1040-positioning block; 1041-receiving seat; 1042-air vent; 1043-lower assembly block; 1044-air vent groove; 1045-third inclined surface; 1046-second magnet; 1047-negative pressure port; 1048-semicircular hole; 1049-through hole; 1050-threaded hole. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0030] like Figure 1-Figure 9 A negative pressure filtration device and a chemical synthesis workstation are shown, wherein the chemical synthesis workstation comprises a base 2, on which are mounted a negative pressure filtration device, a moving component 3, a pipetting head 5, a liquid storage component 6, and a reaction area 7; the moving component 3 is mounted with a pipetting component 4, the movement of the pipetting component 4 is controlled by the moving component 3, the pipetting component 4 performs pipetting, and after the pipetting is completed, negative pressure filtration is performed by the negative pressure filtration device.

[0031] In this embodiment, a negative pressure filtration device is also disclosed, which includes a filtration module 1, which is installed on a base 2 through a pad. The filtration module 1 includes a negative pressure component 103, and a ventilation pipe 8 is arranged on the lower side of the negative pressure component 103. The ventilation pipe 8 is used for exhausting air. The negative pressure component 103 is equipped with a filter module 102 and a receiving plate 101. The liquid after the reaction is completed is moved to the filter module 102 using the pipetting component 4, and the liquid in the filter module 102 is pumped into the receiving plate 101 through the negative pressure component 103.

[0032] like Figure 4-Figure 5As shown, the negative pressure assembly 103 includes a lower assembly block 1043, a third inclined surface 1045 and a ventilation groove 1044 are arranged on the inner side of the lower assembly block 1043, the ventilation groove 1044 is arranged at two ends located on the inner side of the lower assembly block 1043, two second magnets 1046 are fixedly arranged on the upper end of the lower assembly block 1043, a negative pressure port 1047 is arranged at the bottom end of the lower assembly block 1043, and a ventilation pipe 8 is detachably mounted on the negative pressure port 1047, which is connected by threads in this embodiment.

[0033] A receiving seat 1041 is placed in the lower assembly block 1043. Air holes 1042 are provided at both ends of the receiving seat 1041, and their positions correspond to the air grooves 1044, so that the upper and lower spaces of the receiving seat 1041 can be connected. The lower end of the air hole 1042 is clamped in the lower assembly block 1043 through the third inclined surface 1045, which facilitates positioning and ensures the stability of the connection. Positioning blocks 1040 are provided at the four corners of the upper end of the receiving seat 1041.

[0034] The upper end of the lower assembly block 1043 is connected to the upper assembly block 1034, and the lower end of the upper assembly block 1034 is provided with two first magnets 1039. The positions of the first magnets 1039 and the second magnets 1046 correspond to each other, so that the upper assembly block 1034 and the lower assembly block 1043 can be fixed together by magnetic force. The lower end of the upper assembly block 1034 is provided with a second positioning ring 1037 and a second sealing strip 1038. The second sealing strip 1038 fits with the lower assembly block 1043 for sealing, and the second positioning ring 1037 cooperates with the third inclined surface 1045 for positioning; the upper end of the upper assembly block 1034 is provided with a second inclined surface 1035, and the upper assembly block 1034 is fixed with the first sealing strip 1036.

[0035] The upper end of the upper assembly block 1034 is connected to a cover plate 1031, and a plurality of threaded holes 1050 are provided on the cover plate 1031. A plurality of through holes 1049 are provided on the upper assembly block 1034. The fixing screws pass through the through holes 1049 and are screwed into the threaded holes 1050 to fix the cover plate 1031 and the upper assembly block 1034 together. A first inclined surface 1032 is provided on the inner side of the upper cover plate 1031, and a first positioning ring 1033 is fixedly mounted on the lower side of the cover plate 1031. The first positioning ring 1033 cooperates with the second inclined surface 1035 for positioning, and a semicircular hole 1048 is provided on the inner side of the cover plate.

[0036] like Figure 6 , Figure 7As shown, the receiving plate 101 includes a receiving seat 1011, and a plurality of receiving tubes 1013 are arranged in the receiving seat 1011. In the present embodiment, eight rows of receiving tubes 1013 are arranged, and twelve are arranged in each row. The upper end surface of the receiving seat 1011 is provided with a first label 1014 and a second label 1015, and each row and each column is marked for the convenience of positioning and identification. A positioning seat 1012 is provided at the lower end of the receiving seat 1011. The receiving plate 101 is placed on the receiving seat 1041, and is positioned and fixed by the positioning seat 1012 and the positioning block 1040.

[0037] like Figure 8 , Fig. 9 As shown, the filter module 102 includes a filter seat 1021, on which a plurality of filter tubes 1022 are arranged, the number and position of the filter tubes 1022 correspond one-to-one with the receiving tube 1013, a plurality of capillary tubes 1024 are arranged on the lower side of the filter seat 1021, the position and number of the capillary tubes 1024 correspond one-to-one with the filter tubes 1022, and the capillary tubes 1024 are connected, and a filter filler 1023 is installed between the filter tubes 1022 and the capillary tubes 1024.

[0038] Working principle: Before using the filtration module 1, first place the receiving seat 1041 in the lower assembly block 1043, and then place the receiving plate 101 on the receiving seat 1041. The positioning block 1040 on the receiving seat 1041 clamps the positioning seat 1012 for positioning and fixing. The four corners of the filter seat 102 are clamped in the semicircular hole 1048, and the upper assembly block 1034 is placed on the lower assembly block 1043 and fixed by the magnetic force of the second magnet 1046 and the first magnet 1039. The third inclined surface 1045 and the second positioning ring 1037 are positioned and matched, and the second sealing strip 1038 can be sealed. The cover plate 1031 is placed on the upper assembly block 1034 and positioned by the first positioning ring 1033 and the second inclined surface 1035. The filter seat 1021 is placed on the first sealing strip 1036 and positioned by the first inclined surface 1032. The ventilation pipe 8 is fixed in the negative pressure port 1047 by threads.

[0039] Start the moving component 3 to drive the pipetting component 4 to move in the X, Y, and Z axes. The pipetting component 4 reaches the pipetting head 5 to pick up the gun tip, and then absorbs the reaction liquid from the liquid storage component 6 to the reaction area 7 for reaction. Then, the gun tip is replaced to absorb different reaction liquids from the liquid storage component 6 and add them to the reaction area 7 for reaction. After the reaction is completed, the solution is moved to the filter tube 1022 through the pipetting component 4, and air is pumped through the ventilation tube 8 to generate negative pressure in the lower combination block 1043. The solution in the filter tube 1022 is filtered by the filter filler 1023 and flows through the capillary 1024 into the receiving tube 1013. The remaining residue or precipitation remains in the filter tube 1022.

Claims

1. A negative pressure filtration device, characterized in that: The invention comprises a suction filtration module (1), wherein the suction filtration module (1) comprises a negative pressure component (103), wherein a receiving plate (101) and a filter module (102) are installed in the negative pressure component (103), and the filter module (102) is located above the receiving plate (101).

2. A negative pressure filtration device according to claim 1, characterized in that: The filter module (102) comprises a filter seat (1021), a plurality of filter tubes (1022) are arranged in the filter seat (1021), a capillary tube (1024) is arranged on the lower side of each filter tube (1022), and a filter filler (1023) is installed between the capillary tube (1024) and the filter tube (1022).

3. A negative pressure filtration device according to claim 1, characterized in that: The receiving plate (101) comprises a receiving seat (1011), on which a plurality of receiving tubes (1013) are arranged, and an upper end surface of the receiving seat (1011) is provided with a first label (1014) and a second label (1015), and the position of each receiving tube (1013) is marked by the first label (1014) and the second label (1015).

4. A negative pressure filtration device according to claim 3, characterized in that: The negative pressure assembly (103) comprises a lower assembly block (1043), a receiving seat (1041) is installed in the lower assembly block (1043), the receiving plate (101) is located on the receiving seat (1041), an upper assembly block (1034) is installed on the upper side of the lower assembly block (1043), and a cover plate (1031) is installed on the upper side of the upper assembly block (1034).

5. A negative pressure filtration device according to claim 4, characterized in that: A first positioning ring (1033) is provided on the lower side of the cover plate (1031), and a second inclined surface (1035) is provided on the upper end of the upper assembly block (1034); the second inclined surface (1035) cooperates with the first positioning ring (1033) to determine the positions of the cover plate (1031) and the upper assembly block (1034).

6. A negative pressure filtration device according to claim 5, characterized in that: A first sealing strip (1036) is provided in the upper assembly block (1034), a first inclined surface (1032) is provided in the cover plate (1031), and the lower end of the filter module (102) contacts the first sealing strip (1036) for sealing.

7. A negative pressure filtration device according to claim 6, characterized in that: The lower assembly block (1043) is provided with a third inclined surface (1045), the receiving seat (1041) contacts the lower assembly block (1043) through the third inclined surface (1045), a venting groove (1044) is provided in the lower assembly block (1043), a venting hole (1042) is provided on the receiving seat (1041), and the receiving seat (1011) is placed on the receiving seat (1041).

8. A negative pressure filtration device according to claim 4, characterized in that: Four positioning blocks (1040) are arranged at the upper end of the receiving seat (1041), which are located at the four corners of the receiving seat (1041), and the filter module (102) is stuck in the positioning blocks (1040).

9. A negative pressure filtration device according to claim 7, characterized in that: A second magnet (1046) is disposed on the upper side of the lower assembly block (1043), and a first magnet (1039) is disposed on the lower end of the upper assembly block (1034), and the two are fixed to each other by magnetic force.

10. A chemical synthesis workstation, comprising the negative pressure filtration device according to any one of claims 1 to 9, characterized in that: The invention comprises a base (2), wherein the filtration module (1) is mounted on the base (2) via a cushion seat, wherein a moving component (3), a liquid transfer head (5), a liquid storage component (6), and a reaction area (7) are mounted on the base (2), and a liquid transfer component (4) is mounted on the moving component (3).

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