Sampling device and detection system for fentanyl compounds

Abstract

The utility model discloses a sampling device and a detection system for fentanyl compounds. The sampling device comprises a box body, a sampling piece, a sample extraction container, a detection container and a coagulant container, the containing space is at least divided into a first storage chamber used for containing the sampling piece, a second storage chamber used for containing the sample extraction container, a third storage chamber used for containing the detection container and a fourth storage chamber used for containing the coagulant container through the partition pieces, and the sampling piece is at least used for collecting a target object on an object; the sample extraction container is provided with an inner cavity for packaging an extracting solution, the inner cavity at least can be used for accommodating a sampling piece for partially enriching a target object, a surface-enhanced Raman reagent is packaged in the detection container, and a coagulant is packaged in the coagulant container. The kit is convenient to carry, simple and convenient to operate in the detection process, high in sensitivity and suitable for on-site drug enforcement screening work of public security and customs departments.

Description

Technical Field

[0001] The utility model relates to a sampling device and a detection system for fentanyl compounds, belonging to the technical field of sample detection equipment. Background Art

[0002] Since fentanyl compounds are highly toxic, easy to synthesize, change quickly, and difficult to inspect, criminals use parcels, luggage, and cargo to covertly traffic them, making on-site inspections difficult to carry out. The traditional detection method is to first open the package to take samples, and then directly test them through colorimetry, immunoassay, infrared spectroscopy, Raman spectroscopy, ion mobility spectroscopy, atmospheric pressure mass spectrometry, etc. This consumes a lot of time and cost, is difficult to adapt to the needs of rapid testing, and cannot ensure that every package must be inspected. Considering that criminals may contaminate fentanyl residues on the box seal, tape, or even the surface when packaging fentanyl compounds, there is an urgent need for a collection and detection kit that can collect and detect residual fentanyl compounds on the outer packaging of the package without unpacking the package. Utility Model Content

[0003] In view of the deficiencies in the prior art, the purpose of the utility model is to provide a sampling device and a detection system for fentanyl compounds.

[0004] In order to achieve the above-mentioned utility model purpose, the technical solution adopted by the utility model includes:

[0005] The utility model provides a sampling device for fentanyl compounds, comprising a box, a sampling piece, a sample extraction container, a detection container and a coagulant container. A accommodating space is arranged inside the box, and the accommodating space is divided by a partition to form at least a first storage chamber for accommodating the sampling piece, a second storage chamber for accommodating the sample extraction container, a third storage chamber for accommodating the detection container and a fourth storage chamber for accommodating the coagulant container. The sampling piece is at least used to collect a target object on an article, the sample extraction container is provided with an inner cavity for encapsulating an extracting liquid, and the inner cavity can at least be used to accommodate the sampling piece for partially enriching the target object, the detection container is encapsulated with a surface enhanced Raman reagent, and the coagulant container is encapsulated with a coagulant.

[0006] Furthermore, the sampling member includes a gripping portion and a sampling portion which are connected in sequence, and the sampling portion is at least used to collect the target object.

[0007] Furthermore, a fold is provided at one end of the holding portion close to the sampling portion, and the holding portion and the sampling portion are separated by applying an external force to the fold.

[0008] Furthermore, the fold is a continuous linear groove structure, and the fold is arranged around the circumference of the gripping portion.

[0009] Furthermore, the fold includes a plurality of V-shaped grooves, and the plurality of V-shaped grooves are evenly spaced along the circumference of the gripping portion.

[0010] Furthermore, the sampling portion is a double-layer polyester knitted structure.

[0011] Furthermore, the sampling portion is a flat sheet structure.

[0012] Furthermore, the sample extraction container includes a bottle body and a bottle cap, the bottle body is provided with the inner cavity, the bottle cap is detachably connected to the bottle body, the bottle cap is provided with a dropper opening and a tube cap at one end opposite to the bottle body, the dropper opening is communicated with the inner cavity, and the tube cap can be sleeved on the dropper opening to close the dropper opening.

[0013] Furthermore, the sample extraction container also includes a connecting piece, one end of which is connected to the bottle body, and the other end of which is connected to the bottle cap.

[0014] Furthermore, a filter is provided at one end of the bottle cap close to the bottle body, and the aperture of the filter is smaller than the width of the sampling member.

[0015] Furthermore, the bottle body is a soft structure.

[0016] Furthermore, the box body includes a box body and a box cover hinged at one end of the box body, the accommodating space is provided inside the box body, and the box body and the box cover are both light-shielding structures.

[0017] Furthermore, the separator is an elastic and flexible structure.

[0018] Furthermore, the detection container includes a glass bottle body and a sealing cover, and the glass bottle body and the sealing cover are detachably connected to open or close the opening of the glass bottle body. The surface enhanced Raman reagent is accommodated inside the glass bottle body, and the inner wall surface of the glass bottle is a passive structure.

[0019] Furthermore, the surface enhanced Raman reagent includes uniformly distributed nano-gold particles.

[0020] Furthermore, the particle size of the nano-gold particles is 35-80 nm.

[0021] Furthermore, the coagulant container is a dropper bottle structure.

[0022] The utility model also provides a detection system for fentanyl compounds, comprising a portable Raman spectrometer and any one of the above-mentioned detection devices for fentanyl compounds.

[0023] Furthermore, the accommodating space is separated into a fifth storage chamber by the partition, and the fifth storage chamber is used to accommodate the portable Raman spectrometer.

[0024] Compared with the prior art, the advantages of the utility model include:

[0025] (1) The sampling device and detection system for fentanyl compounds provided by the utility model are easy to carry, simple to operate during the detection process, and highly sensitive, and are suitable for on-site drug screening work by public security and customs departments.

[0026] (2) The sampling piece provided in the embodiment of the utility model adopts a large flat head, an easy-folding head, and a double-layer polyester knitted material, which has good adsorption and elution properties. The easy-folding head design allows multiple swabs to be immersed in the eluent, thereby achieving full coverage of sampling and concentration enrichment.

[0027] (3) The sample extraction container provided in the embodiment of the utility model is sealed with an extraction liquid and has a replaceable dripper design, which is convenient for directly installing the dripper after eluting the fentanyl compound. This design makes the operation simpler and faster, and is convenient for non-technical personnel on site to operate.

[0028] (4) The detection container provided in the embodiment of the utility model is a glass bottle with a passive inner wall structure, which can be directly loaded with nano-gold particle sol, eliminating the process of users taking samples by themselves, saving manpower and time.

[0029] (5) The coagulant container provided in the embodiment of the utility model is a dropper bottle structure. When using it, only a few drops need to be added according to the instructions, which saves the process of using a pipette to transfer the reagent, thus simplifying the operation.

[0030] (6) The portable Raman spectrometer combined with surface enhanced Raman scattering technology in the utility model has the advantages of high sensitivity, high accuracy, and suitability for aqueous phase systems compared to other detection methods such as colorimetry, ion mobility spectrometry, mass spectrometry, and immunoassay, and provides fingerprint spectral information of fentanyl compounds, which is particularly suitable for on-site trace analysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0032] Figure 1 It is a schematic structural diagram of a sampling device for fentanyl compounds in one embodiment of the utility model;

[0033] Figure 2 This is a schematic diagram of the structure of a sampling member in one embodiment of the utility model;

[0034] Figure 3 It is a structural schematic diagram of a sample extraction container in one embodiment of the utility model.

[0035] Description of reference numerals:

[0036] 100. Box body; 110. Accommodating space; 111. First storage chamber; 112. Second storage chamber; 113. Third storage chamber; 114. Fourth storage chamber; 115. Fifth storage chamber; 120. Partition; 130. Box body; 140. Box cover; 200. Sampling piece; 210. Grip; 220. Sampling part; 230. Fold; 300. Sample extraction container; 310. Inner cavity; 320. Bottle body; 330. Bottle cover; 331. Dropper mouth; 332. Tube cap; 340. Connector; 350. Filter; 400. Detection container; 500. Coagulant container; 600. Portable Raman spectrometer. DETAILED DESCRIPTION

[0037] In view of the deficiencies in the prior art, the inventor of this case has proposed the technical solution of the utility model after long-term research and extensive practice. The technical solution, its implementation process and principle will be further explained as follows.

[0038] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the protection scope of the present invention is not limited to the specific embodiments disclosed below.

[0039] In addition, in the description of the present invention, it should be understood that the terms "upper", "lower", "inside", "outside", "horizontal", "vertical", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0040] In the description of this specification, the description with reference to the terms "one embodiment", "an embodiment", "the embodiment", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0041] The technical solution, its implementation process and principle will be further explained below in conjunction with the accompanying drawings.

[0042] See also Figure 1-Figure 3 A sampling device for fentanyl compounds includes a housing 100, a sampling piece 200, a sample extraction container 300, a detection container 400 and a coagulant container 500. The housing 100 is provided with a accommodating space 110, and the accommodating space 110 is divided by a partition 120 to form at least a first storage chamber 111 for accommodating the sampling piece 200, a second storage chamber 112 for accommodating the sample extraction container 300, a third storage chamber 113 for accommodating the detection container 400 and a fourth storage chamber 114 for accommodating the coagulant container 500. The sampling piece 200 is at least used to collect target objects on an article, the sample extraction container 300 is provided with an inner cavity 310 for encapsulating an extract, and the inner cavity 310 can be used to at least accommodate the sampling piece 200 that partially enriches the target object, the detection container 400 is encapsulated with a surface enhanced Raman reagent, and the coagulant container 500 is encapsulated with a coagulant.

[0043] In this embodiment, if Figure 1 As shown, the box body 100 is a rectangular parallelepiped structure, the box body 100 is a hollow structure and an opening is provided on the top of the box body 100, the opening and the hollow structure form a storage space 110, the partition 120 is customized according to the components to be accommodated, the partition 120 is installed in the storage space 110, and the partition 120 divides the storage space 110 into a first storage chamber 111, a second storage chamber 112, a third storage chamber 113 and a fourth storage chamber 114 according to its own structure, wherein the unused sampling component 200 is placed in the first storage chamber 111, the sample extraction container 300 is placed in the second storage chamber 112, the detection container 400 is placed in the third storage chamber 113, and the coagulant container 500 is placed in the fourth storage chamber 114. When in use, the sampling piece 200 can be used to adsorb and collect target objects suspected of fentanyl compounds contaminated on the surface of the object, and then the part of the sampling piece 200 that collects the target object is placed in the sample extraction container 300. The extracting liquid in the sample extraction container 300 can elute the target object from the sampling piece 200, so that the target object and the extracting liquid are mixed to obtain a sample solution, and then a certain amount of coagulant in the coagulant container 500 is dripped into the detection container 400 and mixed with the surface enhanced Raman reagent, and finally a certain amount of sample solution is dripped into the detection container 400 and mixed to obtain the sample to be detected.

[0044] In the specific structure of the sampling member 200, the sampling member 200 includes a gripping portion 210 and a sampling portion 220 connected in sequence, and the sampling portion 220 is at least used to collect the target object. A fold 230 is provided at one end of the gripping portion 210 close to the sampling portion 220, and an external force is applied to the fold 230 to separate the gripping portion 210 and the sampling portion 220. The sampling portion 220 is a double-layer polyester knitted structure, and the sampling portion 220 is a flat sheet structure.

[0045] Among them, Figure 2 As shown, when the user is sampling, he can hold the gripping portion 210 of the sampling piece 200 and sample the target object through the sampling portion 220, which is convenient for the user to sample and effectively avoids the user from contacting the collected target object. In addition, a fold 230 is also provided on the gripping portion 210. After collecting the target object, the gripping portion 210 can be broken at the fold 230 by external force, so that the sampling portion 220 and the gripping portion 210 are separated, so that the sampling portion 220 can be placed in the sample extraction container 300 alone. First, the volume of the sampling piece 200 placed in the sample extraction container 300 can be reduced; second, the gripping portion 210 that the user directly contacts can be effectively prevented from entering the sample extraction container 300, which is prone to impurities and thus affects the extraction effect. Among them, the sampling part 220 can be a double-layer polyester knitted structure, so that when collecting, it is easy to fill and absorb the target object into the fiber. The knitted structure can intercept pollutants in the knitted structure during the sampling process, collect chemical substances to the maximum extent and release them into the extract to provide an excellent recovery rate. The use of polyester fiber can have good adsorption properties and easy elution. In addition to polyester fiber, the sampling part 220 can also be knitted with nylon, glass fiber and other materials. The structure of the sampling part 220 is a flat sheet structure, which can effectively increase the collection area and improve the collection efficiency. In addition, the gripping part 210 can be made of PP material, which has the characteristics of light weight, good toughness and good chemical resistance.

[0046] The fold 230 may be a continuous linear groove structure, and the fold 230 is disposed around the circumference of the grip portion 210. Alternatively, the fold 230 includes a plurality of V-shaped grooves, and the plurality of V-shaped grooves are evenly spaced along the circumference of the grip portion 210.

[0047] In the specific structure of the sample extraction container 300, the sample extraction container 300 includes a bottle body 320 and a bottle cap 330, the bottle body 320 is provided with an inner cavity 310, the bottle cap 330 is detachably connected to the bottle body 320, and the bottle cap 330 is provided with a dropper mouth 331 and a tube cap 332 at one end opposite to the bottle body 320, the dropper mouth 331 is connected to the inner cavity 310, and the tube cap 332 can be sleeved on the dropper mouth 331 to close the dropper mouth 331. The sample extraction container 300 also includes a connecting piece 340, one end of the connecting piece 340 is connected to the bottle body 320, and the other end is connected to the bottle cap 330. The bottle body 320 is a soft structure.

[0048] In this embodiment, if Figure 3 As shown, the sample extraction container 300 includes a bottle body 320 and a bottle cap 330. The inner cavity 310 in the bottle body 320 is filled with an extracting solution. After the collected sampling part 220 is placed in the inner cavity 310, the bottle cap 330 is connected to the bottle body 320. One end of the bottle cap 330 is provided with a dropper mouth 331 connected to the inner cavity 310. After the target object of the sampling part 220 is eluted and mixed with the extracting solution to form a sample solution, the sample solution can be dripped into the detection container 400 through the dropper mouth 331, so that the operation is simple and convenient, and the dosage of dripping can be easily controlled. After a certain amount of sample solution is dripped, the dropper mouth 331 is closed through the pipe cap 332. In addition, the bottle cap 330 with a dropper mouth 331 of different sizes can be replaced to control the speed and measurement of dripping. In addition, the bottle cap 330 and the bottle body 320 are connected by a connector 340 to avoid the situation where the bottle cap 330 is easily lost. The bottle body 320 is a soft structure, and the sampling part 220 and the extracting solution can be fully contacted by squeezing the bottle body 320, thereby improving the elution efficiency of the target. The bottle body 320 can be made of polyethylene material, which has excellent biological safety and chemical resistance. Exemplarily, the sample extraction container 300 can be a 5ml polyethylene dropper, which contains 2ml of extracting solution, and the extracting solution is a mixed solution of water and ethanol, wherein the volume ratio of water to ethanol is V 水 :V 乙醇 =9∶1.

[0049] In addition, a filter 350 is provided at one end of the bottle cap 330 close to the bottle body 320, and the aperture of the filter 350 is smaller than the width of the sampling member 200. The filter 350 is detachably installed in the bottle cap 330, and when the sample solution is dripped into the detection container 400, the filter 350 can effectively block the sampling part 220, so as to prevent the sampling part 220 from blocking the dropper port 331, thereby causing problems such as difficulty in discharging the liquid.

[0050] In the specific structure of the box 100, the box 100 includes a box body 130 and a box cover 140 hinged at one end of the box body 130. The box body 130 is provided with a storage space 110 inside. The box body 130 and the box cover 140 are both light-shielding structures. The box cover 140 is also hinged at one end of the top of the box 100, so as to facilitate carrying and storage. The box body 130 and the box cover 140 can be a black light-shielding structure, which is more convenient for storage. In addition, the separator 120 is a flexible structure with elasticity. When carrying and transporting the device, the internal components can be buffered and protected. The separator 120 can be made of materials such as sponge, polyurethane foam or silicone.

[0051] In the specific structure of the detection container 400, the detection container 400 includes a glass bottle body and a sealing cover, the glass bottle body and the sealing cover are detachably connected to open or close the opening of the glass bottle body, the surface enhanced Raman reagent is contained inside the glass bottle body, and the inner wall surface of the glass bottle is a passive structure. The surface enhanced Raman reagent includes uniformly distributed nano-gold particles. The particle size of the nano-gold particles is 35-80nm.

[0052] In this embodiment, the detection container 400 includes a glass bottle body, in which a surface enhanced Raman reagent is encapsulated, and the surface enhanced Raman reagent includes nano-gold particles, wherein the inner wall of the glass bottle body can be passivated by silanization, which can effectively prevent the nano-gold particles from adhering to the inner wall, so that the nano-gold particles can be stored for at least half a year, thereby improving the shelf life. Exemplarily, the detection container 400 can be a 4 ml silanized glass bottle, which contains 300 microliters of sol-like nano-gold particles, wherein the particle size of the nano-gold particles is 35-80 nm, and the nano-gold particles can be purchased commercially.

[0053] Further, the coagulant container 500 is a dropper bottle structure. Exemplarily, the coagulant container 500 can be a dropper bottle made of polytetrafluoroethylene, which is corrosion-resistant and has no precipitation, and contains a coagulant inside. The coagulant can be a mixed solution of potassium iodide and magnesium sulfate, wherein C 碘化钾 =0.05mol / L, n 碘化钾 ∶n 硫酸镁 =1∶2.

[0054] The utility model also provides a detection system for fentanyl compounds, including a portable Raman spectrometer 600 and a device for detecting fentanyl compounds. The storage space 110 is separated by a partition 120 into a fifth storage chamber 115, and the fifth storage chamber 115 is used to accommodate the portable Raman spectrometer 600. The portable Raman spectrometer 600 detects the sample to be detected obtained above, and preferably, the portable Raman spectrometer 600 can select a 785nm laser.

[0055] Example

[0056] The unused sampling member 200 is placed in the first storage chamber 111 , the sample extraction container 300 is placed in the second storage chamber 112 , the detection container 400 is placed in the third storage chamber 113 , and the coagulant container 500 is placed in the fourth storage chamber 114 .

[0057] Among them, the sampling piece 200 is specially used to adsorb fentanyl-like substances contaminated on the surface of objects (parcels, luggage, cargo, etc.). When selecting the sampling piece 200 for trace chemicals, this embodiment uses a sampling piece 200 with a sampling portion 220 made of a double-layer polyester knitted material, which has good adsorption properties and is easy to elute. When eluted with pure water or an organic solvent, the chemical substances can be effectively eluted from the sampling piece 200. The cleverness of the knitted design lies in the fact that pollutants are trapped in the knitted structure during the sampling process, and the chemical substances are collected to the maximum extent and released into the extractant to provide an excellent recovery rate. Secondly, the sampling portion 220 selects a certified low TOC level (<50ug / L, <50ppb) to ensure the consistency of the background contribution of the wipe sampling portion 220. In addition, the sampling portion 220 is a large flat head, which can contact the contaminated material with a larger area, and the holding portion 210 made of PP material with a fold 230 can be broken off at the top and placed in the sample extraction container 300, so that multiple sampling portions 220 can be placed in the extraction bottle for multiple samplings and fully eluted together.

[0058] The sample extraction container 300 is a sealed 5 mL disposable extraction tube. The bottle body 320 is made of polyethylene (PE) material. PE has excellent biological safety and chemical resistance. 2 mL of extraction solution is filled inside and sealed. The composition of the extraction solution is a mixed solution of water and ethanol (V 水 :V 乙醇 =9:1). When in use, tear off the sealing cover first, then break off the used sampling piece 200, put the sampling part 220 into the sample extraction container 300, immerse it in the extracting solution, cover the bottle cap 330, and repeatedly squeeze the sample extraction container 300 for 3 times for standby use, so that the collected target object is fully eluted into the extracting solution and mixed with the extracting solution to form a sample solution.

[0059] The detection container 400 is a 4mL silanized glass bottle, which contains 300 microliters of sol-like nano-gold particles. The inner surface of the glass bottle is passivated (silanized), which is very important for maintaining the nano-gold particles stored in the glass container, preventing the nano-gold particles from adhering to the surface of the container, so that they can be stored for at least half a year. The nano-gold sol selects commercial nano-gold particles, and the particle size varies from 35 to 80nm.

[0060] The coagulant container 500 is a polytetrafluoroethylene dropper bottle. This material is corrosion-resistant and has no precipitation, and is suitable for containing the coagulant used based on surface enhanced Raman scattering technology. Under the action of the coagulant, the nano-gold particles and the target molecules, especially the fentanyl compounds, effectively aggregate to achieve the Raman signal enhancement of the fentanyl compounds. The coagulant is a mixed solution of potassium iodide and magnesium sulfate (C 碘化钾 =0.05mol / L, n 碘化钾 ∶n 硫酸镁 =1:2). When in use, the amount of solution required by the operating manual is dripped into the detection container 400, and then the sample solution is dripped into the container, mixed and then placed in the portable Raman spectrometer 600 for detection.

[0061] The best choice for the portable Raman spectrometer 600 is the 785nm laser. The spectrometer with this excitation wavelength can be combined with surface enhanced Raman scattering technology to adjust the surface plasma resonance by controlling the size of the nanogold particles, so that the Raman signal reaches the strongest at this excitation wavelength. Through a large number of experimental verifications, the optimal size is 35nm commercial nanogold particles. After that, the long-wavelength 1064nm laser was compared. Its energy is low, the measurement time is long, the Raman signal is weak, the heat dissipation and spectral resolution are poor, and its energy cannot excite the SPR between the nanogold particles and the target molecules. Therefore, it is impossible to use surface enhanced Raman scattering technology to detect trace fentanyl compounds. In addition, the portable Raman spectrometer 600 has an automatic spectrum analysis function, which can provide accurate detection results for the operator's reference.

[0062] Taking the detection of fentanyl compounds on the surface of a mailing parcel as an example, the use of this practical detection kit includes the following steps:

[0063] Step 1: Take three sampling pieces 200 to wipe the suspected fentanyl compounds on the surface of the mailing package. The first piece is used to wipe the tape at one end of the seal, the second piece is used to wipe the tape at the other end of the seal, and the third piece is used to wipe other places on the surface of the box 100.

[0064] Step 2: Break off three sampling pieces 200, put the sampling parts 220 of the three sampling pieces 200 into the sample extraction container 300, and squeeze them repeatedly for 3 times. The extracting liquid in the sample extraction container 300 will elute the fentanyl compounds and mix with the extracting liquid to form a sample solution. Install the bottle cap 330 with a dropper port 331 for use.

[0065] Step 3: Add 2 drops of coagulant in the coagulant container 500 to the detection container 400 and mix well.

[0066] Step 4: Add one drop of the sample solution in step 2 into the detection container 400, mix well to form a sample to be detected, and wait for detection.

[0067] Step 4: Place the sample to be tested into the test chamber of the portable Raman spectrometer 600 and obtain the test result with one-button operation.

[0068] The working principle of a sampling device and detection system for fentanyl compounds provided in the embodiment of the utility model includes:

[0069] The device is mainly based on Raman spectroscopy to qualitatively screen trace fentanyl compounds on the surface of objects. Conventional Raman spectroscopy can only detect pollutants with a content of more than 1%. For residual fentanyl compounds that are contaminated and cannot be seen by the naked eye, conventional Raman cannot be used to detect them. Therefore, it is impossible to solve the above problem on site with a portable Raman spectrometer 600, and it is necessary to achieve trace detection through early sample collection and processing and surface enhanced Raman scattering technology, so that the portable Raman spectrometer 600 can give accurate and effective detection results. Therefore, this device integrates sample collection, extraction, surface enhanced Raman scattering technology, and Raman spectrometer into a box 100, which is convenient for staff to achieve rapid screening on site. The key technologies are the selection of collection devices, the configuration of extraction reagents, the formulation of reagents in surface enhanced Raman scattering technology, and a suitable Raman spectrometer.

[0070] First, the target fentanyl compound is adsorbed on the surface of the sampling piece 200. Based on physical adsorption, it is necessary to select a sampling piece 200 with strong adsorption, large adsorption area and easy head folding. The target object collected by multiple sampling pieces 200 is dissolved in the extract to achieve an enrichment effect.

[0071] Since surface enhanced Raman scattering technology is based on water phase operation, the extraction solution should be an organic solvent / water solution, such as methanol / water, ethanol / water, acetone / water, rather than a pure organic solvent. For human health and safety considerations, an ethanol / water mixed solution is the best choice.

[0072] The formulation of reagents in surface enhanced Raman scattering technology is very critical. The design of Raman spectroscopy detection system and parameters is very specific to the target compound being measured. The first is the selection of the type and concentration of the coagulant, and the second is the order and volume ratio of the coagulant, extract, and nano-gold particles. Through a large number of optimization experiments, it was determined that the optimal coagulant is a mixed solution of potassium iodide and magnesium sulfate (C 碘化钾 =0.05mol / L, n 碘化钾 ∶n 硫酸镁 =1:2); first add the coagulant to the nano-gold particles, then add the extract, and the order cannot be changed. The volume ratio is V 纳米金粒子 :V 凝聚剂 :V 提取液 =10∶1∶1.

[0073] Finally, the test liquid treated by surface enhanced Raman scattering technology is placed in a suitable portable Raman spectrometer 600 for testing. The built-in software of the portable Raman spectrometer is a boon to the police officers on the scene. People without chemical background can make judgments based on the intuitive results given by the instrument. If it is a fentanyl compound, the name of the substance will be given, such as fentanyl, carfentanil, remifentanil, etc.

[0074] The present invention provides a collection and detection kit for trace amounts of fentanyl compounds on the surface of objects. The kit is simple to prepare, easy to carry, and convenient for sampling. Frontline police officers with non-chemical backgrounds can also quickly and accurately perform on-site operations according to the instructions, especially for rapid extraction and on-site detection of trace amounts of fentanyl compounds that may be contaminated on the surfaces of objects such as parcels, luggage, and goods. It should be understood that the above embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with this technology to understand the content of the present invention and implement it accordingly, and cannot be used to limit the scope of protection of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be covered within the scope of protection of the present invention.

Claims

1. A sampling device for fentanyl compounds, characterized in that: include: A box body, a sampling piece, a sample extraction container, a detection container and a coagulant container, wherein a storage space is provided inside the box body, and the storage space is divided by a partition to form at least a first storage chamber for accommodating the sampling piece, a second storage chamber for accommodating the sample extraction container, a third storage chamber for accommodating the detection container and a fourth storage chamber for accommodating the coagulant container, wherein the sampling piece is at least used to collect target objects on articles, the sample extraction container is provided with an inner cavity for encapsulating an extracting liquid, and the inner cavity can be used to at least partially accommodate the sampling piece for enriching the target objects, the detection container encapsulates a surface enhanced Raman reagent, and the coagulant container encapsulates a coagulant.

2. The sampling device for fentanyl compounds according to claim 1, characterized in that: The sampling member comprises a gripping portion and a sampling portion connected in sequence, and the sampling portion is at least used to collect the target object; And / or, a fold is provided at one end of the holding portion close to the sampling portion, and an external force is applied to the fold to separate the holding portion and the sampling portion; And / or, the fold is a continuous linear groove structure, and the fold is arranged around the circumference of the gripping portion; And / or, the fold includes a plurality of V-shaped grooves, and the plurality of V-shaped grooves are evenly spaced along the circumference of the gripping portion.

3. The sampling device for fentanyl compounds according to claim 2, characterized in that: The sampling part is a double-layer polyester knitted structure; And / or, the sampling portion is a flat sheet structure.

4. The sampling device for fentanyl compounds according to claim 1, characterized in that: The sample extraction container comprises a bottle body and a bottle cap, wherein the bottle body is provided with the inner cavity, the bottle cap is detachably connected to the bottle body, and the bottle cap is provided with a dropper opening and a tube cap at one end opposite to the bottle body, the dropper opening is communicated with the inner cavity, and the tube cap can be sleeved on the dropper opening to close the dropper opening; And / or, the sample extraction container further comprises a connecting piece, one end of which is connected to the bottle body, and the other end of which is connected to the bottle cap; And / or, a filter screen is provided at one end of the bottle cap close to the bottle body, and the aperture of the filter screen is smaller than the width of the sampling member.

5. The sampling device for fentanyl compounds according to claim 4, characterized in that: The bottle body is a soft structure.

6. The sampling device for fentanyl compounds according to claim 5, characterized in that: The box body comprises a box body and a box cover hinged at one end of the box body, the box body is provided with the accommodation space inside, and both the box body and the box cover are light-shielding structures; And / or, the separator is a flexible structure with elasticity.

7. The sampling device for fentanyl compounds according to claim 1, characterized in that: The detection container comprises a glass bottle body and a sealing cover, wherein the glass bottle body and the sealing cover are detachably connected to open or close the opening of the glass bottle body, the surface enhanced Raman reagent is contained inside the glass bottle body, and the inner wall surface of the glass bottle is a passive structure; And / or, the surface enhanced Raman reagent comprises uniformly distributed nano-gold particles; And / or, the particle size of the nano-gold particles is 35-80 nm.

8. The sampling device for fentanyl compounds according to claim 1, characterized in that: The coagulant container is a dropper bottle structure.

9. A detection system for fentanyl compounds, characterized in that: The invention comprises a portable Raman spectrometer and a device for using fentanyl compounds as claimed in any one of claims 1 to 8.

10. The detection system for fentanyl compounds according to claim 9, characterized in that: The storage space is separated into a fifth storage chamber by the partition, and the fifth storage chamber is used to store the portable Raman spectrometer.

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