A new type of medical bionic bone screw

Abstract

The utility model provides a novel medical bionic bone screw, comprising a bionic bone screw body, wherein the bionic bone screw body comprises a base layer, a first functional layer and a second functional layer, wherein the first functional layer comprises a hydroxyapatite coating and a bioactive glass coating, and the second functional layer comprises a polypeptide self-assembled monolayer coating and a silver nanoparticle coating. By setting the first functional layer comprising the hydroxyapatite coating and the bioactive glass coating, wherein the hydroxyapatite coating is a mineral naturally existing in human bones and teeth, and is applied as a coating on the bone screw, the chemical and crystal structure of natural bones can be imitated, thereby improving the biocompatibility with human bones. The coating can promote the adhesion and proliferation of bone cells, accelerate the growth of bone tissue and the natural repair process of bones, and the bioactive glass coating can form a strong chemical bond with bone tissue to promote the growth of bone tissue.

Description

Technical Field

[0001] The utility model relates to a bionic bone screw, in particular to a novel medical bionic bone screw, belonging to the technical field of biomedical engineering. Background Art

[0002] In the field of biomedical engineering, bionic bone screws are an innovative technology that mimics the mechanisms of nature to design and manufacture medical implants for fracture treatment. These screws are usually made of highly biocompatible materials that can integrate well with human bone tissue. Their surface structure and chemical properties are optimized to promote bone cell growth and bone reconstruction, thereby accelerating the patient's recovery process and reducing surgical complications.

[0003] Authorization announcement number (CN205458999U) discloses a bone screw, which relates to a surgical instrument device, and in particular to a bone screw, including a nut and a screw rod fixedly connected thereto, the screw rod being provided with an external thread, characterized in that a plurality of grooves are provided on the outer edge of the thread. The bone screw of the present invention, by providing grooves on the outer edge of the thread, does not reduce the height of the thread itself, but reduces the contact area between the thread and the bone, reduces friction, and does not damage the main body of the screw column itself, thereby ensuring the height of the screw itself.

[0004] However, the material biocompatibility of the above-mentioned bone screws may not be high, so they cannot provide a good cell adhesion and proliferation environment, and it is difficult to induce bone cells to deposit new bone on their surface. After implantation, they may not integrate well with the body's own bones, resulting in poor stability after implantation, which may increase the risk of secondary displacement at the fracture site and prolong the patient's recovery time. In addition, if the biocompatibility of the screws is insufficient, it may induce local inflammatory reactions or even rejection reactions, which will not only affect the healing process of the affected area, but may also require additional surgical intervention to replace the implant or perform other treatment measures, which will bring greater physical and economic burdens to patients;

[0005] Therefore, a new type of medical bionic bone screw is proposed. Utility Model Content

[0006] In view of this, the utility model provides a novel medical bionic bone screw to solve or alleviate the technical problems existing in the prior art and at least provide a beneficial choice.

[0007] The technical solution of the utility model is implemented as follows: it includes a bionic bone screw body, the bionic bone screw body includes a base layer, a first functional layer and a second functional layer, the first functional layer includes a hydroxyapatite coating and a bioactive glass coating, and the second functional layer includes a polypeptide self-assembled monolayer coating and a silver nanoparticle coating.

[0008] Further preferably, the first functional layer is arranged on the outside of the base layer, and the second functional layer is arranged on the outside of the first functional layer.

[0009] Further preferably, the hydroxyapatite coating is disposed on the outside of the substrate layer, and the bioactive glass coating is disposed on the outside of the hydroxyapatite coating.

[0010] Further preferably, the polypeptide self-assembled monolayer coating is disposed on the outside of the bioactive glass coating, and the silver nanoparticle coating is disposed on the outside of the polypeptide self-assembled monolayer coating.

[0011] Further preferably, the thickness of the hydroxyapatite coating and the bioactive glass coating are consistent, and are both 1 μm-2 μm.

[0012] Further preferably, the thickness of the polypeptide self-assembled monolayer coating and the silver nanoparticle coating are consistent, and are both 1 μm-3 μm.

[0013] The embodiment of the utility model has the following advantages due to the adoption of the above technical solution:

[0014] The utility model provides a first functional layer including a hydroxyapatite coating and a bioactive glass coating, wherein the hydroxyapatite coating is a mineral naturally present in human bones and teeth. When applied as a coating on bone screws, it can imitate the chemical and crystal structure of natural bones, thereby improving the biocompatibility with human bones. This coating can promote the adhesion and proliferation of bone cells, accelerate the growth of bone tissue and the natural repair process of bones, and the bioactive glass coating can form a strong chemical bond with bone tissue to promote the growth of bone tissue. The ions (such as silicon, calcium, and phosphorus) released by this material can stimulate bone formation and healing processes, increase the speed of new bone formation, and it also has antibacterial properties. , which can reduce the risk of infection after surgery, and set a second functional layer including a polypeptide self-assembled monolayer coating and a silver nanoparticle coating. The polypeptide self-assembled monolayer coating is a nanostructured coating formed by a self-assembly process of short-chain peptide molecules. These short-chain peptide molecules can be designed to mimic naturally occurring signal peptides in the human body, thereby promoting cell attachment and proliferation and accelerating bone repair. In addition, this coating has extremely high biocompatibility, can reduce foreign body reactions and inflammation, and accelerate the bone integration process. Silver nanoparticle coatings have been widely studied for their excellent antibacterial properties. They can not only effectively resist infections from a variety of bacteria, but also reduce the risk of postoperative infection, creating a safer environment for bone healing.

[0015] The above summary is for the purpose of description only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments and features described above, further aspects, embodiments and features of the utility model will be readily apparent by reference to the accompanying drawings and the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 This is a front view of the main structure of the utility model;

[0018] Figure 2 This is a structural diagram of the bionic bone screw body in the utility model;

[0019] Figure 3 This is the structural diagram of the first functional layer in the utility model;

[0020] Figure 4 This is a structural diagram of the second functional layer in the utility model.

[0021] Reference numerals: 1, bionic bone screw body; 2, connecting rod; 3, pneumatic actuator; 101, base layer; 102, first functional layer; 1021, hydroxyapatite coating; 1022, bioactive glass coating; 103, second functional layer; 1031, polypeptide self-assembled monolayer coating; 1032, silver nanoparticle coating; DETAILED DESCRIPTION

[0022] In the following, only some exemplary embodiments are briefly described. As those skilled in the art will appreciate, the described embodiments may be modified in various ways without departing from the spirit or scope of the present invention. Therefore, the drawings and descriptions are considered to be exemplary and non-restrictive in nature.

[0023] The embodiments of the present utility model are described in detail below with reference to the accompanying drawings.

[0024] Example 1

[0025] like Figure 1-4As shown, the embodiment of the utility model provides a bionic bone screw body 1, the bionic bone screw body 1 includes a base layer 101, a first functional layer 102 and a second functional layer 103, the first functional layer 102 includes a hydroxyapatite coating 1021 and a bioactive glass coating 1022, the second functional layer 103 includes a polypeptide self-assembled monolayer coating 1031 and a silver nanoparticle coating 1032, the first functional layer 102 is arranged on the outside of the base layer 101, the second functional layer 103 is arranged on the outside of the first functional layer 102, the hydroxyapatite coating 1021 The bioactive glass coating 1022 is arranged on the outside of the hydroxyapatite coating 1021, the polypeptide self-assembled monolayer coating 1031 is arranged on the outside of the bioactive glass coating 1022, and the silver nanoparticle coating 1032 is arranged on the outside of the polypeptide self-assembled monolayer coating 1031. The thickness of the hydroxyapatite coating 1021 and the bioactive glass coating 1022 is consistent, and both are 1μm-2μm. The thickness of the polypeptide self-assembled monolayer coating 1031 and the silver nanoparticle coating 1032 is consistent, and both are 1μm-2μm.

[0026] When the utility model is working: by setting a first functional layer 102 including a hydroxyapatite coating 1021 and a bioactive glass coating 1022, wherein the hydroxyapatite coating 1021 is a mineral naturally present in human bones and teeth, and is applied as a coating on bone screws, it can imitate the chemical and crystal structure of natural bones, thereby improving the biocompatibility with human bones. This coating can promote the adhesion and proliferation of bone cells, accelerate the growth of bone tissue and the natural repair process of bones, and the bioactive glass coating 1022 can form a strong chemical bond with bone tissue to promote the growth of bone tissue. The ions released by this material (such as silicon, calcium, and phosphorus) can stimulate bone formation and healing processes, increase the speed of new bone formation, and it also has anti- The invention has antibacterial properties and can reduce the risk of infection after surgery. A second functional layer 103 is provided, which includes a polypeptide self-assembled monolayer coating 1031 and a silver nanoparticle coating 1032. The polypeptide self-assembled monolayer coating 1031 is a nanostructured coating formed by a self-assembly process of short-chain peptide molecules. These short-chain peptide molecules can be designed to mimic naturally occurring signal peptides in the human body, thereby promoting cell attachment and proliferation and accelerating bone repair. In addition, this coating has extremely high biocompatibility, can reduce foreign body reactions and inflammation, and accelerate the bone integration process. The silver nanoparticle coating 1032 has been widely studied for its excellent antibacterial properties. It can not only effectively resist infection from a variety of bacteria, but also reduce the risk of postoperative infection, creating a safer environment for bone healing.

[0027] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited thereto. Any technician familiar with the technical field can easily think of various changes or substitutions within the technical scope disclosed by the utility model, which should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope of the claims.

Claims

1. A novel medical bionic bone screw, characterized in that: The bionic bone screw body (1) comprises a base layer (101), a first functional layer (102) and a second functional layer (103), wherein the first functional layer (102) comprises a hydroxyapatite coating (1021) and a bioactive glass coating (1022), and the second functional layer (103) comprises a polypeptide self-assembled monolayer coating (1031) and a silver nanoparticle coating (1032).

2. A novel medical bionic bone screw according to claim 1, characterized in that: The first functional layer (102) is arranged on the outside of the base layer (101), and the second functional layer (103) is arranged on the outside of the first functional layer (102).

3. The novel medical bionic bone screw according to claim 1, characterized in that: The hydroxyapatite coating (1021) is arranged on the outside of the base layer (101), and the bioactive glass coating (1022) is arranged on the outside of the hydroxyapatite coating (1021).

4. The novel medical bionic bone screw according to claim 1, characterized in that: The polypeptide self-assembled monolayer coating (1031) is disposed on the outside of the bioactive glass coating (1022), and the silver nanoparticle coating (1032) is disposed on the outside of the polypeptide self-assembled monolayer coating (1031).

5. The novel medical bionic bone screw according to claim 1, characterized in that: The thickness of the hydroxyapatite coating (1021) and the bioactive glass coating (1022) are consistent, and are both 1 μm-2 μm.

6. The novel medical bionic bone screw according to claim 1, characterized in that: The thickness of the polypeptide self-assembled monolayer coating (1031) and the silver nanoparticle coating (1032) are consistent, and are both 1 μm-2 μm.

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