Sampling detection device based on Raman spectrum principle

Abstract

The utility model discloses a sampling detection device based on a Raman spectrum principle. The sampling detection device comprises a sampling head, a reagent cavity and a solution release mechanism, the sampling head is arranged on one side of the reagent cavity, the other side of the reagent cavity is connected with the solution release mechanism, and an isolating layer is arranged between the sampling head and the reagent cavity; the sampling detection device based on the Raman spectrum principle is small, light and convenient to carry and operate; the operation is simple, and sampling and detection can be completed without complicated professional skills; through double guarantee of the two mechanisms, the device can be effectively prevented from being damaged when being carried, so that a solution enters the sampling head; a sample can be quickly obtained and subjected to Raman spectrum analysis, and a real-time detection result is provided.

Description

Technical Field

[0001] The utility model relates to the technical field of medical detection, in particular to a sampling detection device based on the principle of Raman spectroscopy. Background Technique

[0002] Surface-enhanced Raman spectroscopy technology is widely used in medical detection. By analyzing the Raman scattering spectrum of a sample, the structure and composition of various molecules in the sample can be detected. However, the existing sampling is generally carried out by using a cotton swab to sample, then immersing the sample in a solvent for dissolution and adding an enhancement substrate, and finally putting it into a Raman spectroscopy detector for detection. However, if sampling needs to be carried out outdoors, the enhancement substrate solvent is not convenient to carry and is also prone to splashing during operation. Therefore, there is a need for a sampling device that is convenient to carry and operate to meet the requirements. Content of the Utility Model

[0003] The technical problem to be solved by the utility model is: to solve the problem that the sampling device in the prior art is not easy to carry and the operation is cumbersome. The utility model provides a sampling detection device based on the principle of Raman spectroscopy.

[0004] The technical solution adopted by the utility model to solve its technical problem is: a sampling detection device based on the principle of Raman spectroscopy, including a sampling head, a reagent chamber and a solution release mechanism; the sampling head is arranged on one side of the reagent chamber, and the other side of the reagent chamber is connected to the solution release mechanism, and an isolation layer is arranged between the sampling head and the reagent chamber.

[0005] Further, a two-way valve structure is arranged in the middle of the isolation layer. The two-way valve structure includes a valve body, a one-way flow-through membrane arranged in the valve body and a pressure trigger mechanism. When the reagent is stored in the reagent chamber, the two-way valve structure can prevent the reagent from flowing out to the sampling head, and at the same time, when the solution needs to be released, the solution can wet the sampling head.

[0006] Further, the valve body is made of a material with a certain elasticity and can undergo elastic deformation under an external force.

[0007] Further, the valve body adopts a medical-grade silicone material or a thermoplastic elastomer material.

[0008] Further, the one-way flow-through membrane is made of a hydrophobic material and has a microporous structure.

[0009] Further, the pressure trigger mechanism includes an elastic element and a pressure plate. The elastic element is disposed on the side of the one-way flow membrane close to the reagent chamber, and the pressure plate is disposed on the side of the elastic element away from the one-way flow membrane. In the normal state, the one-way flow membrane is in a closed state, preventing the solution from entering the sampling head from the middle cavity. When it is necessary to release the solution, an external pressure is applied, and the pressure trigger mechanism is activated, causing the one-way flow membrane to open, and the solution flows into the sampling head to wet the sample.

[0010] Further, the reagent chamber is a hollow cylinder.

[0011] Further, the sampling head is made of cotton.

[0012] Further, the sampling head adopts a composite multi-layer structure, and the composite multi-layer structure includes β-cyclodextrin, chitosan, carboxymethyl cellulose and cotton. The adoption of the composite multi-layer structure is beneficial to the separation and adsorption of different substances after sampling.

[0013] Further, the solution release mechanism is a tube body connected to the reagent chamber, and an easy break is provided at the connection between the solution release mechanism and the reagent chamber to facilitate the separation of the solution release mechanism from the reagent chamber. When the solution release mechanism is connected to the reagent chamber, the reagent chamber is in a negative pressure state, which can ensure that the reagent will not flow downward. After breaking the connection between the solution release mechanism and the reagent chamber through the easy break, the pressure in the reagent chamber becomes normal, and then the one-way membrane is opened through the two-way valve structure to make the solution flow to the sampling head.

[0014] Advantages of the present utility model:

[0015] The sampling and detection device based on the Raman spectroscopy principle of the present utility model is small, light and portable, convenient for carrying and operation; the operation is simple, and sampling and detection can be completed without complex professional skills; through the double guarantee of two mechanisms, it can effectively prevent the device from being damaged during carrying and causing the solution to enter the sampling head; and it can quickly obtain samples and perform Raman spectroscopy analysis to provide immediate detection results. Description of the Drawings

[0016] The present utility model will be further described below in conjunction with the drawings and embodiments.

[0017] Figure 1 It is a schematic diagram of the sampling and detection device based on the Raman spectroscopy principle described in Embodiment 1 of the present utility model;

[0018] Figure 2 It is a schematic diagram of the two-way valve structure described in Embodiment 1 of the present utility model;

[0019] In the figure, 1 is a sampling head, 2 is a reagent chamber, 3 is a solution releasing mechanism, 4 is an isolation layer, 5 is a two-way valve structure, 51 is a valve body, 52 is a one-way flow membrane, 53 is a pressure triggering mechanism, 531 is an elastic element, 532 is a pressure plate, and 6 is a frangible point. Detailed implementation mode

[0020] The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the drawings, where the same or similar reference numerals represent the same or similar elements or elements with the same or similar functions from beginning to end. The embodiments described below by referring to the drawings are exemplary and are only used to explain the present invention and should not be construed as a limitation to the present invention.

[0021] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "horizontal", "top", "inner", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention.

[0022] In the description of the present invention, it should be noted that unless otherwise clearly specified and limited, the term "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0023] Embodiment 1

[0024] As Figure 1-2 shown, a sampling and detection device based on the Raman spectroscopy principle includes a sampling head 1, a reagent chamber 2, and a solution releasing mechanism 3; the sampling head 1 is arranged on one side of the reagent chamber 2, the other side of the reagent chamber 2 is connected to the solution releasing mechanism 3, and an isolation layer 4 is provided between the sampling head 1 and the reagent chamber 2.

[0025] A two-way valve structure 5 is provided in the middle of the isolation layer 4. The two-way valve structure 5 includes a valve body 51, a one-way flow membrane 52 arranged in the valve body 51, and a pressure triggering mechanism 53. When the two-way valve structure 5 stores the reagent in the reagent chamber 2, it can prevent the reagent from flowing out onto the sampling head 1, and at the same time, it can make the solution wet the sampling head 1 when the solution needs to be released.

[0026] The valve body 51 is made of a material with a certain elasticity and can undergo elastic deformation under an external force. The valve body 51 is made of a medical-grade silicone material or a thermoplastic elastomer material. The one-way flow membrane 52 is made of a hydrophobic material and has a microporous structure.

[0027] The pressure trigger mechanism 53 includes an elastic element 531 and a pressure plate 532. The elastic element 531 is arranged on the side of the one-way flow membrane 52 close to the reagent chamber 2, and the pressure plate 532 is arranged on the side of the elastic element 531 away from the one-way flow membrane 52; in the normal state, the one-way flow membrane is in a closed state, preventing the solution from entering the sampling head 1 from the hollow cavity. When it is necessary to release the solution, an external pressure is applied, and the pressure trigger mechanism is activated, causing the one-way flow membrane to open, and the solution flows into the sampling head 1 to wet the sample.

[0028] The reagent chamber 2 is a hollow cylinder. The sampling head 1 is made of cotton; the solution release mechanism 3 is a tube body connected to the reagent chamber 2, and an easy break 6 is provided at the connection between the solution release mechanism 3 and the reagent chamber 2 to facilitate separating the solution release mechanism 3 from the reagent chamber 2; when the solution release mechanism 3 is connected to the reagent chamber 2, the reagent chamber 2 is in a negative pressure state, which can ensure that the reagent will not flow downward. After breaking the connection between the solution release mechanism 3 and the reagent chamber 2 through the easy break 6, the pressure in the reagent chamber 2 becomes normal, and then the one-way membrane is opened through the two-way valve structure 5 to make the solution flow to the sampling head 1.

[0029] During use, the reagent is injected into the reagent chamber 2, and the solution release mechanism 3 is connected to the end of the reagent chamber 2 away from the sampling head 1; when sampling, the sampling head 1 is gently wiped on the part to be detected, such as the skin or the inner wall of the mouth; after sampling, the connection between the solution release mechanism 3 and the reagent chamber 2 is broken through the easy break 6, so that the solution flows downward. At the same time, pressure is applied outside the pressure trigger mechanism 53, and the pressure is transmitted to the pressure plate 532, compressing the elastic element 531 to open the one-way flow membrane. At this time, the solution continues to flow downward until it flows to the sampling head 1 to wet the sample; through the double guarantee of the two mechanisms, it can effectively prevent the device from being damaged during carrying and causing the solution to enter the sampling head 1; then the device can be placed under a Raman spectrometer for Raman spectroscopy analysis to obtain the detection result.

[0030] Embodiment 2

[0031] On the basis of Embodiment 1, this embodiment also provides a sampling detection device based on the Raman spectroscopy principle, and its structure is substantially the same as that of the sampling detection device based on the Raman spectroscopy principle disclosed in Embodiment 1. The difference is that the sampling head adopts a composite multi-layer structure, and the composite multi-layer structure includes β-cyclodextrin, chitosan, carboxymethyl cellulose and cotton; adopting the composite multi-layer structure is beneficial to the separation and adsorption of different substances after sampling.

[0032] In this specification, the schematic descriptions of the terms do not necessarily refer to the same embodiments. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments in a suitable manner.

[0033] Based on the above inspiration from the ideal embodiments of the present utility model, through the above description, relevant staff can completely make various changes and modifications without departing from the technical idea of the present utility model. The technical scope of the present utility model is not limited to the content in the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. A sampling and detection device based on the principle of Raman spectroscopy, characterized in that: The invention comprises a sampling head (1), a reagent chamber (2) and a solution releasing mechanism (3); the sampling head (1) is arranged on one side of the reagent chamber (2), the other side of the reagent chamber (2) is connected to the solution releasing mechanism (3), and an isolation layer (4) is arranged between the sampling head (1) and the reagent chamber (2).

2. The sampling and detection device based on the Raman spectroscopy principle according to claim 1 is characterized in that: A two-way valve structure (5) is provided in the middle of the isolation layer (4), and the two-way valve structure (5) comprises a valve body (51), a one-way flow membrane (52) arranged in the valve body (51), and a pressure trigger mechanism (53).

3. The sampling and detection device based on the Raman spectroscopy principle according to claim 2 is characterized in that: The valve body (51) is made of a material with a certain elasticity and can undergo elastic deformation under the action of external force.

4. The sampling and detection device based on the Raman spectroscopy principle according to claim 3 is characterized in that: The valve body (51) is made of medical grade silicone material or thermoplastic elastomer material.

5. The sampling and detection device based on the Raman spectroscopy principle according to claim 2 is characterized in that: The one-way flow membrane (52) is made of a hydrophobic material and has a microporous structure.

6. The sampling and detection device based on the Raman spectroscopy principle according to claim 2 is characterized in that: The pressure trigger mechanism (53) comprises an elastic element (531) and a pressure plate (532), wherein the elastic element (531) is arranged on a side of the one-way flow membrane (52) close to the reagent chamber (2), and the pressure plate (532) is arranged on a side of the elastic element (531) away from the one-way flow membrane (52).

7. The sampling and detection device based on the Raman spectroscopy principle according to claim 1 is characterized in that: The reagent chamber (2) is a hollow cylinder.

8. The sampling and detection device based on the Raman spectroscopy principle according to claim 1 is characterized in that: The sampling head (1) is made of cotton.

9. The sampling and detection device based on the Raman spectroscopy principle according to claim 1 is characterized in that: The sampling head (1) is a composite multilayer structure, which comprises beta-cyclodextrin, chitosan, carboxymethyl cellulose and cotton.

10. The sampling and detection device based on the Raman spectroscopy principle according to claim 1, characterized in that: The solution release mechanism (3) is a tube body connected to the reagent chamber (2), and a breakable opening (6) is provided at the connection between the solution release mechanism (3) and the reagent chamber (2) for facilitating separation of the solution release mechanism (3) and the reagent chamber (2).

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