Cold insulation device

Abstract

The utility model discloses a cold insulation device which is used for cooling a cell plate and comprises a cover plate assembly, an auxiliary heat conduction assembly, a base and a heat medium, and the cover plate assembly comprises a cover plate body and a main heat conduction pipe; the auxiliary heat conduction assembly comprises a bottom plate and an auxiliary heat conduction pipe. A containing cavity used for containing a heat medium is formed among the combined rear cover plate body, the base and the auxiliary heat conduction assembly, and the main heat conduction pipe extends into the containing cavity. During use, a preset amount of heat medium is arranged in the accommodating cavity, the cover plate body covers the base and seals the base, the cell plate is arranged at the top of the cover plate body, and the main heat guide pipe extends into the accommodating cavity, so that the main heat guide pipe can quickly and uniformly transfer heat of the cell plate to the heat medium; the auxiliary heat conduction assembly can rapidly transfer heat to the middle of the containing cavity, the heat transfer efficiency is improved through combination of the two, and efficient cold insulation is achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of cell culture plate cooling devices, in particular to a cold insulation device. Background Art

[0002] Molecular biology and cell biology experiments have strict requirements for temperature. In experiments, various enzyme reactions need to be carried out with liquid addition operations in a low-temperature environment. Usually, an operating environment of about 4°C needs to be maintained. Some commercially available small or simple automated workstations only have a pipetting function and do not have a temperature control function module. If there is a temperature control requirement in the experiment, the original instrument is not applicable, and a temperature control module needs to be added or a large automated workstation needs to be purchased, which is relatively expensive. Currently, the corresponding experimental devices on the market can be mainly divided into two categories: the first category uses a self-made ice box; the second category uses a special metal block.

[0003] Self-made ice box: Use a foam box, pipette tip box or other box-shaped items of appropriate size, place wet ice or ice packs in the box and stack them flat, and place the cell plate on the ice for experiments. The wet ice or ice packs in the cold insulation device will melt as the temperature rises, resulting in a change in the temperature of the contact surface of the well plate, affecting the experimental results and reliability. Moreover, since the wet ice in the box melts, the height of the well plate on the ice also changes, so it is not applicable to automated workstations.

[0004] Metal block: Place the metal block in a 4°C refrigerator for refrigeration and place it in the plate position of the automated workstation. The metal block will linearly rise continuously with the indoor temperature due to heat absorption, resulting in a change in the temperature of the contact surface of the well plate, affecting the experimental results and reliability. If its cold insulation time is to be extended and it is placed in a lower temperature environment of -20°C or -80°C, when taking it out, the metal block will freeze the reagents in the well plate, resulting in the inability to conduct the experiment.

[0005] Therefore, how to achieve high-efficiency cold insulation is a technical problem that needs to be solved by those skilled in the art at present. Content of the Utility Model

[0006] In view of this, the purpose of the utility model is to provide a cold insulation device to achieve high-efficiency cold insulation;

[0007] To achieve the above purpose, the utility model provides the following technical solutions:

[0008] A cold insulation device for cooling a cell plate, comprising a cover plate assembly, a heat medium and a base, wherein:

[0009] The cover plate assembly includes a cover plate body and a main heat pipe;

[0010] The cover plate body is used to carry the cell plate and seal the base;

[0011] When the cover plate body seals the base, the heat medium is in contact with the main heat pipe;

[0012] A receiving cavity for accommodating a heat medium is formed between the cover body and the base;

[0013] The main heat pipe is arranged close to the base direction and fixed to the cover body;

[0014] The main heat pipe extends into the interior of the receiving cavity.

[0015] Optionally, in the above-mentioned cold insulation device, the cold insulation device further includes an auxiliary heat conduction component, which is arranged at the bottom of the base. When the cover body closes the base, the main heat pipe, the auxiliary heat conduction component and the heat medium form a heat transfer loop.

[0016] Optionally, in the above-mentioned cold insulation device, the number of main heat pipes is multiple and they are joined together to form a heat conduction area.

[0017] Optionally, in the above-mentioned cold insulation device, the auxiliary heat conduction component includes a bottom plate and a tutoring heat pipe, where:

[0018] The bottom plate is matched with the bottom of the base;

[0019] The tutoring heat pipe is arranged close to the cover component direction and fixed to the bottom plate.

[0020] Optionally, in the above-mentioned cold insulation device, the main heat pipe is C-shaped and / or L-shaped.

[0021] Optionally, in the above-mentioned cold insulation device, the bottom plate is made of a heat-conducting material.

[0022] Optionally, in the above-mentioned cold insulation device, a heat insulation layer is arranged on the inner wall of the base.

[0023] Optionally, in the above-mentioned cold insulation device, the number of receiving cavities is one or more.

[0024] Optionally, in the above-mentioned cold insulation device, an annular clamping groove is formed at the top of the base, and the clamping groove is used to clamp the cover body.

[0025] Optionally, in the above-mentioned cold insulation device, the heat medium is an ice-water mixture or ice crystal powder.

[0026] When the cold insulation device provided by the present utility model is in use, a preset amount of heat medium is arranged inside the receiving cavity, the cover body covers the base and closes the base, and the cell plate is arranged on the top of the cover body. Because the main heat pipe extends into the interior of the receiving cavity, the main heat pipe can quickly and evenly transfer the heat of the cell plate to the heat medium, thereby improving the heat transfer efficiency and achieving high-efficiency cold insulation. Description of the Drawings

[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0028] Figure 1 Structural schematic diagram of the cover plate assembly disclosed in the embodiment of the present invention;

[0029] Figure 2 Bottom view of the cover plate assembly disclosed in the embodiment of the present invention;

[0030] Figure 3 Structural schematic diagram of the main heat pipe disclosed in the embodiment of the present invention;

[0031] Figure 4 Structural schematic diagram of the base disclosed in the embodiment of the present invention;

[0032] Figure 5 Structural schematic diagram of the auxiliary heat conduction assembly disclosed in the embodiment of the present invention;

[0033] Figure 6 Installation schematic diagram of the cold insulation device disclosed in the embodiment of the present invention;

[0034] Figure 7 Another angle installation schematic diagram of the cold insulation device disclosed in the embodiment of the present invention;

[0035] Wherein:

[0036] Cover plate assembly 100, cover plate body 101, main heat pipe 102, base 200, auxiliary heat conduction assembly 300, bottom plate 301, auxiliary heat pipe 302. Detailed implementation manners

[0037] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0038] In the description of the present utility model, it should be understood that the orientation or positional relationship indicated by terms such as "upper", "lower", "top surface", "bottom surface", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the indicated position or element must have a specific orientation, be constituted and operated in a specific orientation. Therefore, it should not be construed as a limitation of the present utility model. In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0039] As Figures 1 - 7 shown, the cold insulation device disclosed by the present utility model is used for cooling a cell plate and includes a cover plate assembly 100, a heat medium, and a base 200. Among them, the cover plate assembly 100 includes a cover plate body 101 and a main heat pipe 102. The cover plate body 101 is used to carry the cell plate and close the base 200. When the cover plate body 101 closes the base 200, the heat medium is in contact with the main heat pipe 102. An accommodation cavity for accommodating the heat medium is formed between the cover plate body 101 and the base 200. The main heat pipe 102 is arranged in the direction close to the base 200 and is fixed to the cover plate body 101. The main heat pipe 102 extends into the interior of the accommodation cavity. Specifically, the upper surface of the cover plate body 101 is closely fitted with the bottom of the cell plate to ensure the cooling effect on the cell plate. Specifically, the present utility model preferably selects the base 200 to be made of nylon material and is turned by a numerical control machine tool.

[0040] When the cold insulation device provided by the present utility model is in use, a preset amount of heat medium is arranged inside the accommodation cavity. The cover plate body 101 is placed on the base 200 and closes the base 200. The cell plate is arranged on the top of the cover plate body 101. Because the main heat pipe 102 extends into the interior of the accommodation cavity, the main heat pipe 102 can quickly and evenly transfer the heat of the cell plate to the heat medium. At the same time, the auxiliary heat conduction assembly can quickly transfer the heat to the middle of the accommodation cavity. The combination of the two improves the heat transfer efficiency and realizes high-efficiency cold insulation.

[0041] To optimize the above technical solution, the cold insulation device further includes an auxiliary heat conduction component 300, which is arranged at the bottom of the accommodation cavity of the base 200. When the cover body 101 closes the base 200, the main heat pipe 102, the auxiliary heat conduction component 300 and the heat medium form a heat transfer loop. Specifically, the auxiliary heat conduction component 300 is used to improve the heat conduction uniformity of the cold insulation device, and it can be integrally formed with the base 200 or can be detachably connected. In use, the cover body 101 is arranged on the top of the base 200, and both the main heat pipe 102 and the auxiliary heat conduction component 300 are arranged in the heat medium. The heat of the cell plate is guided to the auxiliary heat conduction component 300 through the main heat pipe 102, and the auxiliary heat conduction component 300 transfers the heat to the heat medium to realize the cooling of the cell plate. By changing the contact area between the auxiliary heat conduction component 300 and the heat medium, the heat conduction efficiency of the heat transfer loop can be adjusted.

[0042] By arranging the auxiliary heat conduction component 300, the heat transfer efficiency between the main heat pipe 102 and the heat medium can be improved, thereby realizing the high-efficiency cold insulation of the cell plate by the cold insulation device.

[0043] To optimize the above technical solution, the number of the main heat pipes 102 is multiple, and they are assembled to form a heat conduction area. Specifically, the operator can adjust the number and arrangement position of the main heat pipes 102 according to the usage needs, so as to form heat conduction areas of different sizes and positions, thereby improving the usage flexibility of the cold insulation device. Specifically, the multiple main heat pipes 102 can be freely assembled into various shapes, as long as one end of them can be inserted into the interior of the accommodation cavity to achieve heat conduction.

[0044] To optimize the above technical solution, the main heat pipe 102 is C-shaped and / or L-shaped. Specifically, when the main heat pipe 102 is C-shaped, the middle part of the main heat pipe 102 is connected to the cover body 101, and both ends of it are inserted into the interior of the accommodation cavity to realize heat exchange with the heat medium. At this time, the middle part of the cover body 101 can realize uniform heat exchange with the cell plate, thereby realizing the high-efficiency cold insulation of the cell plate by the cold insulation device. Specifically, when the main heat pipe 102 is L-shaped, by changing the arrangement positions of the multiple main heat pipes 102, the main heat pipes 102 that can be inserted into the accommodation cavity can be arranged on all four sides of the cover body 101, thereby further improving the cold insulation efficiency of the cold insulation device.

[0045] It should be noted that the main heat pipe 102 can be made of any heat-conducting material with arbitrary bending. The operator can change the shape of the main heat pipe 102 according to the usage needs on the premise that one end of it can be inserted into the heat medium, which will not be elaborated here.

[0046] To optimize the above technical solution, the auxiliary heat conduction component 300 includes a bottom plate 301 and a guiding heat pipe 302. Among them, the bottom plate 301 is matched with the bottom of the base 200, and the guiding heat pipe 302 is arranged in the direction close to the cover plate assembly 100 and fixed to the bottom plate 301.

[0047] Specifically, when the auxiliary heat conduction component 300 and the base 200 are integrally designed, the bottom plate 301 is the bottom plate material of the base 200, and the guiding heat pipe 302 is fixed to the bottom of the base 200. When a heat medium is arranged inside the accommodation cavity, the guiding heat pipe 302 can be in contact with the heat medium. Such an arrangement can simplify the installation steps of the cold insulation device, thereby improving its working efficiency.

[0048] Specifically, when the auxiliary heat conduction component 300 and the base 200 are separately designed, in the first embodiment, the base 200 is a through design, that is, a groove for clamping the bottom plate 301 is provided at the bottom of the base 200. The operator arranges the bottom plate 301 in the groove to achieve a tight fit between the bottom plate 301 and the base 200. Subsequently, a heat medium is arranged inside the accommodation cavity, and a heat transfer loop of the main heat pipe 102, the bottom plate 301, the guiding heat pipe 302, and the heat medium can be formed.

[0049] Specifically, when the auxiliary heat conduction component 300 and the base 200 are separately designed, in the second embodiment, the base 200 is integrally designed as a groove type, and a shallow groove for tightly fitting the bottom plate 301 is opened at the bottom of the groove. When the bottom plate 301 is matched with the shallow groove, the bottom plate 301 cannot move in the shallow groove, and the space above the bottom plate 301 and below the cover plate body 101 can be used to accommodate the heat medium.

[0050] By changing the connection method between the base 200 and the bottom plate 301, the flexible use of the cold insulation device can be realized, so that it can be adapted to various models of automated workstations.

[0051] Furthermore, the material and shape of the guiding heat pipe 302 can be the same as those of the main heat pipe 102, but the guiding heat pipe 302 needs to maintain the maximum contact area with the heat medium to achieve rapid heat conduction.

[0052] The present utility model preferably arranges two staggered C-shaped guiding heat pipes 302 on the bottom plate 301, and its side is connected to the bottom plate 301. During use, the end of the main heat pipe 102 transfers the heat of the cell plate to the bottom plate 301. Under the action of the two C-shaped guiding heat pipes 302, the heat is conducted to the middle of the bottom plate 301, so that the temperature change inside the accommodation cavity is more uniform, thereby achieving rapid heat conduction and improving the cold insulation efficiency of the cold insulation device.

[0053] To optimize the above technical solution, the bottom plate 301 is made of a heat-conducting material. Specifically, the bottom plate 301 includes, but is not limited to, metals with good heat-conducting performance and easy processing, such as aluminum, and non-metals with good heat-conducting performance and easy processing, such as graphene patches. Operators can replace the bottom plate 301 according to installation and heat-conducting needs to meet various cold insulation requirements and improve the practicality of the cold insulation device. Further, the external shape of the bottom surface of the base 200 is consistent with the cell plate specifications and can be directly clamped on the platform of the automated workstation to improve its practicality.

[0054] To optimize the above technical solution, a heat-insulating layer is arranged on the inner wall of the base 200. Specifically, the heat-insulating layer is used to prevent heat exchange between the heat medium and the outside world, so as to further improve the heat exchange efficiency between the heat medium and the cell plate and achieve high-efficiency cold insulation of the cell plate by the cold insulation device. After multiple tests and data calculations, at room temperature of 25 °C, the cold insulation device provided by the present utility model can always control the liquid temperature in the cell plate within 4 ± 1 °C and maintain it for about 1 hour, which fully meets the conditions of the liquid temperature in the cell plate during the experiment. Moreover, compared with the cold insulation method of self-made ice boxes, the experimental temperature and the working surface height provided are more stable.

[0055] To optimize the above technical solution, the number of accommodation cavities is one or more. Specifically, operators can provide one or more accommodation cavities inside the base 200 according to usage needs. When the base 200 and the bottom plate 301 are of a detachable design, the shape of the bottom plate 301 changes with the shape of the accommodation cavity so that it can be exactly and tightly arranged at the bottom of the accommodation cavity.

[0056] Further, the cold insulation device provided by the present utility model can be adapted to an automated workstation using 6 / 12 / 24 / 48 / 96 / 384 / 1536-well cell culture plates, and can also be adapted to modules with other specification orifice plates, such as PCR (Polymerase Chain Reaction) plates, by changing the data of the base 200 and the cover plate assembly 100.

[0057] Further, the cold insulation device provided by the present utility model can be placed in any tray position of the automated workstation for experiments. Operators can arbitrarily program its position according to their actual needs, and the number of cold insulation devices can also be flexibly increased or decreased according to actual needs.

[0058] To optimize the above technical solution, an annular clamping groove is opened at the top of the base 200, and the clamping groove is used to clamp the cover plate body 101. During use, when the cover plate body 101 is arranged inside the clamping groove, the cover plate body 101 is limited by the clamping groove to improve the connection stability with the base 200 while achieving a tight fit with the base 200.

[0059] To optimize the above technical solution, the heat medium is ice-water mixture or ice crystal powder. Specifically, the main components of the ice crystal powder are anhydrous sodium carbonate and glycerol, and it can be formulated into an endothermic medium by adding water. Specifically, when the heat medium is an ice-water mixture, it combines the rapid heat conduction characteristics of the main heat pipe 102 and the auxiliary heat pipe 302, as well as the principle of heat absorption during the phase change of the heat medium from ice to water, enabling the cooling device to have a non-linear temperature rise during heat absorption, high cooling efficiency, and the temperature conditions required for experiments can be achieved without complex modification.

[0060] Furthermore, both the ice-water mixture and the ice crystal powder as the heat medium absorb heat for cooling by means of phase change, so no additional energy input is required, and the cooling device itself will not generate heat, which has no impact on the air temperature in the operation area of the automated workstation, and the purified air flow is not disturbed, thus achieving the use effects of safety, reliability, environmental protection and energy conservation.

[0061] It should be noted that in the prior art, there are also a small number of methods for cooling by using a semiconductor refrigeration module, also known as a thermoelectric cooler (TEC). This refrigeration module utilizes the Peltier effect to achieve refrigeration by generating heat transfer between two different conductors through an electric current. The semiconductor refrigeration module has the advantages of small volume, no noise, no vibration, and fast response. However, this module has a high price and limited refrigeration efficiency; at the same time, it is necessary to modify the circuit of the automated workstation to achieve power-on, which has safety risks; because it is an added module later, its heat dissipation is also inside the workstation, and the temperature is easily out of control, affecting the experimental results. Therefore, installing this refrigeration module on the automated workstation is uneconomical, has potential hazards, and is not convenient.

[0062] The advantages of the present utility model are as follows:

[0063] (1) High-efficiency cooling is achieved;

[0064] (2) High flexibility in use and high structural adaptability;

[0065] (3) Environmental protection, energy conservation, strong practicability, and the heat medium is common and easy to obtain.

[0066] It should be noted that the cooling device provided by the present utility model can be used in the technical field of cell culture plate cooling devices or other fields. The other fields refer to any fields other than the technical field of cell culture plate cooling devices. The above is only an example and does not limit the application fields of the cooling device provided by the present utility model.

[0067] In this specification, the various embodiments are described in a progressive manner. Each embodiment focuses on the differences from other embodiments. The same or similar parts among the various embodiments can be referred to each other.

[0068] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present utility model. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present utility model. Therefore, the present utility model will not be limited to the embodiments shown herein, but rather to the broadest scope consistent with the principles and novel features disclosed herein.

[0069] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present utility model. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0070] The preferred embodiments of the present utility model disclosed above are only used to help explain the present utility model. The preferred embodiments do not describe all the details in detail, nor do they limit the present utility model to only the specific implementation manners. Obviously, many modifications and variations can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present utility model, so that those skilled in the art can understand and utilize the present utility model well. The present utility model is only limited by the claims and their full scope and equivalents.

Claims

1. A cold preservation device, characterized in that: For cooling a cell plate, comprising a cover plate assembly, a thermal medium and a base, wherein: The cover plate assembly comprises a cover plate body and a main heat pipe; The cover plate body is used to carry the cell plate and close the base; When the cover plate body closes the base, the heat medium contacts the main heat pipe; A receiving cavity for receiving the heat medium is formed between the cover body and the base; The main heat pipe is arranged close to the base and fixed to the cover body; The main heat pipe extends into the interior of the accommodating cavity.

2. The cold-keeping device according to claim 1, characterized in that: The cold preservation device further comprises an auxiliary heat conducting component, which is arranged at the bottom of the base. When the cover plate body closes the base, the main heat pipe, the auxiliary heat conducting component and the heat medium form a heat transfer loop.

3. The cold preservation device according to claim 1, characterized in that: There are multiple main heat pipes, which are assembled to form a heat conduction area.

4. The cold preservation device according to claim 2, characterized in that: The auxiliary heat conduction component includes a base plate and a heat pipe, wherein: The bottom plate matches the bottom of the base; The auxiliary heat pipe is arranged close to the cover plate assembly and fixed to the bottom plate.

5. The cold preservation device according to claim 1, characterized in that: The main heat pipe is C-shaped and / or L-shaped.

6. The cold preservation device according to claim 4, characterized in that: The bottom plate is made of heat-conducting material.

7. The cold-keeping device according to claim 1, characterized in that: The inner wall of the base is arranged with a heat-insulating layer.

8. The cold-keeping device according to claim 1, characterized in that: The number of the accommodating cavities is one or more.

9. The cold-keeping device according to claim 1, characterized in that: An annular clamping groove is provided on the top of the base, and the clamping groove is used for clamping the cover plate body.

10. The cold-keeping device according to claim 1, characterized in that: The heat medium is an ice-water mixture or ice crystal powder.

Images