Injector sleeve suitable for injecting temperature-sensitive gel, injection device and injection system

Abstract

According to the injector sleeve suitable for injecting the temperature-sensitive gel, the injection device and the injection system, the injector sleeve cools the injection bin in the injector sleeve in a constant-temperature cold water circulation mode and keeps the temperature constant, so that an injector in the injection bin is in a low-temperature state; therefore, it is ensured that the temperature-sensitive gel in the injector is in a constant-temperature and flowing injectable state, the situation that the temperature-sensitive gel is solidified too early and cannot be injected is avoided, and the success rate of a temperature-sensitive gel animal in-vivo injection experiment and the reliability of an experiment result are improved. According to the injection device, the injector can be conveniently replaced, and the injection device is suitable for thermo-sensitive gel injection for long-time and multi-batch animal experiments. The injection device and system are simple in structure, the temperature of constant-temperature cold water can be accurately controlled, meanwhile, the temperature can be set and adjusted according to actual requirements, the stability of the temperature environment in the injector sleeve is effectively kept, and the injection device and system have wide application prospects.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices, and relates to a syringe sleeve, an injection device and an injection system suitable for injecting thermosensitive gel. Background Art

[0002] In biomedical experiments, MatriGEL gel and other thermosensitive gels, as a commonly used cell culture matrix, need to be injected into small animals under low temperature conditions to maintain their stability and activity. When the thermosensitive gel containing 3D cells or organoid clusters enters the animal body, the thermosensitive gel will heat up and solidify automatically. However, traditional syringes and needles cannot control the low temperature, and if the operation is a little careless, it will cause the thermosensitive gel to become solid inside the syringe due to the temperature rise with the environment, and then it is impossible to successfully complete the injection into the animal body. Therefore, it is very necessary to design an easy-to-operate syringe sleeve that can control the constant temperature of the syringe and the needle. Summary of the Utility Model

[0003] The purpose of the utility model is to provide a syringe sleeve, an injection device and an injection system suitable for injecting thermosensitive gel, so as to solve the problem that the thermosensitive gel is easy to solidify due to temperature change when the existing syringe injects the thermosensitive gel.

[0004] To achieve the above purpose, the utility model adopts the following technical solutions:

[0005] In the first aspect, the present application provides a syringe sleeve suitable for injecting thermosensitive gel, which includes a sleeve body, a sandwich layer provided on the barrel wall of the sleeve body, and a water inlet pipe and a water outlet pipe both provided on the outer side wall of the sleeve body. The water inlet pipe and the water outlet pipe are respectively communicated with both ends of the sandwich layer; the inside of the sleeve body is hollow to form an injection chamber, and the injection chamber is close to the sandwich layer.

[0006] Preferably, a syringe fixing member is provided at the top of the sleeve body. The syringe fixing member is communicated with the injection chamber, and fixing grooves are provided on both side walls opposite to the syringe fixing member.

[0007] Preferably, a spiral flow guide flap is provided in the sandwich layer.

[0008] Preferably, the sandwich layer includes a needle body sandwich layer and a needle head sandwich layer that are communicated with each other. The spiral directions of the spiral flow guide flaps in the needle body sandwich layer and the needle head sandwich layer are opposite.

[0009] Preferably, the injection chamber fits the shape of the syringe.

[0010] Preferably, a handle is further provided on the outer side wall of the sleeve body, and the handle is disposed opposite to the water inlet pipe.

[0011] Preferably, the inlets of the water inlet pipe and the water outlet pipe are arranged adjacent to each other.

[0012] In a second aspect, the present application provides an injection device, including any one of the syringe barrels applicable to injecting thermosensitive gels in the first aspect and the syringe, where the syringe is located in the injection chamber of the syringe barrel, and the needle of the syringe is exposed outside the barrel body of the syringe barrel.

[0013] Preferably, the tail wing of the syringe is located in the fixing groove of the syringe barrel.

[0014] In a third aspect, the present application provides an injection system, including the injection device in the second aspect and a water cooling circulator, where the water cooling circulator is connected to the water inlet pipe and the water outlet pipe in the injection device.

[0015] The utility model has the following beneficial effects:

[0016] 1. The syringe barrel is applicable to injecting thermosensitive gels into experimental animals. During injection, it can keep the environmental temperature in the injection chamber constant, so that the syringe in the injection chamber is in a low-temperature state. Furthermore, it can ensure that the thermosensitive gel in the syringe is at a constant temperature and in a flowable injectable state, avoiding premature solidification of the thermosensitive gel and making it impossible to inject, thus improving the success rate of the thermosensitive gel injection experiment in animals and the reliability of the experimental results.

[0017] 2. The injection device can facilitate the replacement of the syringe and is applicable to the injection of thermosensitive gels in long-term and multi-batch animal experiments.

[0018] 3. The structure of the injection system is simple, which can accurately control the temperature of the constant-temperature cold water. At the same time, the temperature can be set and adjusted according to actual needs, effectively maintaining the stability of the temperature environment inside the syringe barrel, and having a wide application prospect. Description of the Drawings

[0019] Figure 1 It is a three-dimensional structural schematic diagram of the syringe barrel applicable to injecting thermosensitive gels provided by the embodiment of the present application;

[0020] Figure 2 It is a front view of the syringe barrel applicable to injecting thermosensitive gels provided by the embodiment of the present application;

[0021] Figure 3 It is a cross-sectional view of the syringe barrel applicable to injecting thermosensitive gels provided by the embodiment of the present application;

[0022] Figure 4 It is a three-dimensional structural schematic diagram of the injection device provided by the embodiment of the present application;

[0023] Symbol representation:

[0024] 1 - Sleeve body, 2 - Interlayer, 3 - Water inlet pipe, 4 - Water outlet pipe, 5 - Injection chamber, 6 - Syringe fixing part, 7 - Fixing groove, 8 - Spiral flow guide flap, 9 - Syringe, 10 - Handle, 11 - Needle, 12 - Tail fin, 201 - Needle body interlayer, 202 - Needle tip interlayer. Detailed implementation mode

[0025] The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0026] Embodiment 1

[0027] The embodiment of the present application provides a syringe sleeve suitable for injecting thermosensitive gel. The syringe sleeve includes a sleeve body 1, an interlayer 2 provided on the barrel wall of the sleeve body 1, and a water inlet pipe 3 and a water outlet pipe 4 both provided on the outer side wall of the sleeve body 1, as shown in the attached Figures 1 - 3 figure.

[0028] Among them, the sleeve body 1 is the main component of the syringe sleeve. To match the syringe, the sleeve body 1 is set as a barrel-shaped structure that is wider at the top and narrower at the bottom. The inside of the sleeve body 1 is hollow and communicates with the outside. The hollow part inside the sleeve body 1 is an injection chamber 5 for placing the syringe 9. To match the syringe, the shape of the injection chamber 5 fits the shape of the syringe 9. In the embodiment of the present application, the injection chamber 5 can be set with multiple inner diameter specifications to facilitate adapting to syringes 9 of different volume specifications.

[0029] An interlayer 2 is provided on the barrel wall of the sleeve body 1, and along the length direction and circumferential direction of the sleeve body 1, the entire barrel wall of the sleeve body 1 has this interlayer 2. The two ends of the interlayer 2 are respectively communicated with the water inlet pipe 3 and the water outlet pipe 4. Thus, cold water enters from the water inlet pipe 3, flows through the interlayer 2, and then flows out through the water outlet pipe 4 to achieve the cooling of the inner wall of the sleeve body 1. In addition, the injection chamber 5 is close to the interlayer 2. When the inner wall of the sleeve body 1 cools down, the temperature at the injection chamber 5 will also decrease, and then the temperature of the syringe 9 placed in the injection chamber 5 will also decrease. When the syringe 9 is filled with thermosensitive gel, the lower-temperature syringe 9 keeps the internal thermosensitive gel in a low-temperature state, and thus will not solidify, ensuring the injection of the thermosensitive gel.

[0030] In the embodiment of the present application, to fix the syringe 9, a syringe fixing member 6 is provided at the top of the sleeve body 1. The syringe fixing member 6 has a groove-shaped structure, with a through hole at the bottom and an open top. The syringe fixing member 6 is communicated with the injection chamber 5 through the through hole. Thus, the syringe 9 can be placed into the injection chamber 5 through the through hole. Fixing grooves 7 are provided on the opposite side walls of the syringe fixing member 6, and the fixing grooves 7 are used to fix the tail wing 12 of the syringe 9. Specifically, when the syringe 9 is placed into the injection chamber 5 through the through hole, the tail wing 12 can be screwed into the fixing groove 7 by rotating 90 degrees to achieve the fixation of the syringe 9.

[0031] In addition, a spiral flow guide flap 8 is provided in the sandwich layer 2 in the embodiment of the present application. The spiral flow guide flap 8 can guide the cold water entering the interior of the sandwich layer 2 to form a circular water flow, and then evenly cool the injection chamber 5 and keep it constant. Further, the sandwich layer 2 includes a needle body sandwich layer 201 and a needle tip sandwich layer 202 that are communicated with each other. Among them, the needle body sandwich layer 201 is located in the upper part of the sleeve body 1 and is used to surround the barrel of the syringe 9. Thus, the cold water flowing through the needle body sandwich layer 201 cools the barrel of the syringe 9. The needle tip sandwich layer 202 is located in the lower part of the sleeve body 1 and is used to surround the needle tip 11 of the syringe 9. Thus, the cold water flowing through the needle tip sandwich layer 202 cools the needle tip 11 of the syringe 9. Spiral flow guide flaps 8 are provided in both the needle body sandwich layer 201 and the needle tip sandwich layer 202, and the spiral directions of the spiral flow guide flaps 8 in the needle body sandwich layer 201 and the needle tip sandwich layer 202 are opposite.

[0032] In the embodiment of the present application, to reduce the distribution of pipelines, the pipe orifices of the water inlet pipe 3 and the water outlet pipe 4 are adjacently arranged. In addition, a handle 10 is further provided on the outer side wall of the sleeve body 1, and the handle 10 is arranged opposite to the water inlet pipe 3. The sleeve body 1 is firmly connected to the handle 10 to ensure the convenience and stability of the injection operation. More preferably, the sleeve body 1 and the handle 10 are integrally formed.

[0033] When the syringe sleeve provided by the embodiment of the present application is in use, after the water inlet pipe 3 and the water outlet pipe 4 are respectively connected to an external cold water device and a water receiving device, constant temperature cold water is introduced into the water inlet pipe 3. The constant temperature cold water enters the sandwich layer 2 through the water inlet pipe 3, forms a circular water flow under the guidance of the internal spiral flow guide flap 8, and then evenly cools the injection chamber 5 and keeps it constant. The constant temperature cold water flows out through the water outlet pipe 4.

[0034] Embodiment 2

[0035] The embodiment of the present application provides an injection device, which includes the syringe sleeve and the syringe 9 in Embodiment 1, as shown in the appendix Figure 4 shown. The syringe 9 is located in the injection chamber 5 of the syringe sleeve. The needle tip 11 of the syringe 9 is exposed outside the sleeve body 1 of the syringe sleeve, and the tail wing 12 of the syringe 9 is located in the fixing groove 7 of the syringe sleeve.

[0036] Specifically, the syringe 9 is pushed into the injection chamber 5 from the through hole of the syringe fixing member 6, and the needle 11 of the syringe 9 is exposed outside the sleeve body 1 of the syringe sleeve. Then, by rotating 90 degrees, the tail fin 12 of the syringe 9 can be screwed into the fixing groove 7 to fix the syringe 9. Injection is achieved through the needle 11 exposed outside the sleeve body 1.

[0037] When the injection device provided by the embodiment of the present application is in use, after connecting the water inlet pipe 3 and the water outlet pipe 4 to an external cold water device and a water receiving device respectively, constant-temperature cold water is injected into the water inlet pipe 3. The constant-temperature cold water enters the interlayer 2 through the water inlet pipe 3 and forms a circular water flow under the guidance of the internal spiral guide vane 8, thereby uniformly cooling the injection chamber 5 and maintaining a constant temperature. When the temperature of the injection chamber 5 is constant, the syringe 9 filled with thermosensitive gel is placed into the injection chamber 5 of the syringe sleeve, and the tail fin 12 of the syringe 9 is rotated 90 degrees and then screwed into the fixing groove 7 to fix the syringe 9. After the injection chamber 5 is cooled, the temperature of the syringe 9 placed inside the injection chamber 5 also decreases, so that the thermosensitive gel inside the syringe 9 is in a low-temperature state and will not solidify, ensuring the injection of the thermosensitive gel.

[0038] Embodiment 3

[0039] The embodiment of the present application provides an injection system, which includes the injection device in Embodiment 2 and a water-cooling circulator. The water-cooling circulator is connected to the water inlet pipe 3 and the water outlet pipe 4 in the injection device to realize water circulation. The water-cooling circulator in the embodiment of the present application is a temperature-controllable device with a circulation water pump to ensure the temperature of the circulating water.

[0040] When the injection system provided by the embodiment of the present application is in use, the water outlet pipe and the water return pipe of the water-cooling circulator are respectively connected to the water inlet pipe 3 and the water outlet pipe 4 in the injection device, and the water temperature is set at a specified temperature, such as 4°C. When the outlet water temperature of the water-cooling circulator reaches the specified temperature, the circulation water pump switch is turned on, so that the constant-temperature cold water enters the water inlet pipe 3 in the injection device, and then the syringe 9 is cooled by the constant-temperature cold water.

[0041] The above are only the preferred embodiments of the present application and are not used to limit the present application. For those skilled in the art, the present application can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A syringe sleeve suitable for injecting a temperature-sensitive gel, characterized in that: The invention comprises a sleeve body (1), an interlayer (2) arranged on the wall of the sleeve body (1), and a water inlet pipe (3) and a water outlet pipe (4) both arranged on the outer wall of the sleeve body (1), wherein the water inlet pipe (3) and the water outlet pipe (4) are respectively connected to two ends of the interlayer (2); an injection chamber (5) is arranged in the hollow interior of the sleeve body (1), and the injection chamber (5) is close to the interlayer (2).

2. The syringe sleeve suitable for injecting temperature-sensitive gel according to claim 1, characterized in that: A syringe fixing part (6) is provided on the top of the sleeve body (1), the syringe fixing part (6) is connected to the injection chamber (5), and fixing grooves (7) are provided on two opposite side walls of the syringe fixing part (6).

3. The syringe sleeve suitable for injecting temperature-sensitive gel according to claim 1, characterized in that: A spiral guide flap (8) is provided in the interlayer (2).

4. The syringe sleeve suitable for injecting temperature-sensitive gel according to claim 3, characterized in that: The interlayer (2) comprises a needle body interlayer (201) and a needle tip interlayer (202) which are connected to each other, and the spiral guide flap (8) in the needle body interlayer (201) and the spiral guide flap (8) in the needle tip interlayer (202) have opposite spiral directions.

5. The syringe barrel suitable for injecting temperature-sensitive gel according to claim 1, characterized in that: The injection chamber (5) matches the shape of the syringe (9).

6. The syringe barrel suitable for injecting temperature-sensitive gel according to claim 1, characterized in that: A handle (10) is also provided on the outer side wall of the sleeve body (1), and the handle (10) is arranged opposite to the water inlet pipe (3).

7. The syringe barrel suitable for injecting temperature-sensitive gel according to claim 1, characterized in that: The pipe openings of the water inlet pipe (3) and the water outlet pipe (4) are arranged adjacent to each other.

8. An injection device, characterized in that: The invention comprises a syringe barrel suitable for injecting a thermosensitive gel as claimed in any one of claims 1 to 7 and the syringe (9), wherein the syringe (9) is located in an injection chamber (5) of the syringe barrel, and a needle (11) of the syringe (9) is exposed outside the barrel body (1) of the syringe barrel.

9. The injection device according to claim 8, characterized in that The tail wing (12) of the syringe (9) is located in the fixing groove (7) of the syringe sleeve.

10. An injection system, characterized in that: It comprises the injection device of claim 8 or 9 and a water-cooling circulator, wherein the water-cooling circulator is connected to a water inlet pipe (3) and a water outlet pipe (4) in the injector.

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