Anti-volatilization device for sample adding port of titration cell for freeze-dried product Karl moisture detection

Abstract

The utility model discloses an anti-volatilization device for a sample adding port of a titration cell for freeze-dried product Karl moisture detection, which comprises a sample adding channel consisting of an upper cylindrical cavity channel and a lower conical cavity channel, an elastic sealing gasket with a cross-shaped notch in the middle is arranged at the upper end of the cylindrical cavity in a sealing and covering mode, an annular blocking table is arranged on the lower edge of the outer wall of the cylindrical cavity in the circumferential direction, a gland is connected to the outer wall, located above the annular blocking table, of the cylindrical cavity in a threaded mode, and a through hole is formed in the center of the top wall of the gland. The sample adding device has the advantages that the sample adding device can be easily inserted into the sample adding opening of the titration cell of the Karl moisture detector, so that harm to detection personnel caused by outward dispersion of toxic gas is avoided, and the moisture detection accuracy of a freeze-dried product in the cell is ensured; a sample adding bottle or a dropper can easily penetrate through the cross-shaped notch, and can quickly rebound to seal the cross-shaped notch when being drawn out, so that the sealing performance of the titration cell of the Karl moisture detector is ensured as much as possible, and the safety of the Karl moisture detection operation of a freeze-dried product is ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of Karl Fischer moisture detection, in particular to a volatilization prevention device for a sample adding port of a titration cell used for Karl Fischer moisture detection of freeze-dried products. Background Art

[0002] The moisture content of lyophilized products in in vitro diagnostic products is a necessary prerequisite for ensuring the accuracy of clinical test results. Therefore, how to more accurately detect the moisture content of lyophilized products is particularly important. Currently, the volumetric titration method using the WKT-C9 Karl Fischer titrator is widely used to detect the moisture content of lyophilized products. However, the opening of the titration cell of this instrument is too large. When the sealing rubber plug is removed and used, the opening will remain open for a long time, causing toxic reagents (such as methanol, Karl Fischer, etc.) in the titration cell to evaporate outward during the addition process, which in turn causes great harm to the test personnel. In addition, because the opening of the opening is too large, moisture from the outside air can easily enter the titration cell, thereby affecting the accuracy of the moisture test results. The impact will be more serious especially in high humidity environments. Summary of the Invention

[0003] The utility model aims to address the defects of the prior art and provide a volatilization prevention device for a sample adding port of a titration cell used for Karl Fischer moisture detection of freeze-dried products.

[0004] In order to achieve the above purpose, the present invention can adopt the following technical solutions:

[0005] The utility model discloses a volatilization prevention device for a sample loading port of a titration cell for Karl Fischer moisture detection of freeze-dried products, comprising a sample loading channel inserted into the sample loading port of a titration cell of a Karl Fischer moisture detector, wherein the sample loading channel is composed of an upper cylindrical cavity and a lower conical cavity; an elastic sealing gasket with a cross cut in the middle is sealed at the upper end of the cylindrical cavity, an annular stop is circumferentially arranged at the lower edge of the outer wall of the cylindrical cavity to block the sample loading port, a pressure cover for pressing the elastic sealing gasket is screwed on the outer wall of the cylindrical cavity located above the annular stop, and a through hole is opened at the center of the top wall of the pressure cover.

[0006] Specifically, the elastic sealing pad is a silicone pad or a rubber pad; the horizontal and vertical lengths of the cross cut are 0.8 to 1.2 cm, and the aperture of the through hole is 1.3 to 1.6 cm.

[0007] The utility model has the advantages that it can be easily inserted into the sample addition port of the titration cell of the Karl Fischer moisture detector, so that the elastic sealing gasket covering the upper end of the sample addition channel can be used to block the gas generated by the volatilization of the toxic reagent in the titration cell of the Karl Fischer moisture detector from diffusing outwards, and at the same time can effectively prevent the outside air from entering the titration cell of the Karl Fischer moisture detector, thereby avoiding the harm to the detection personnel caused by the toxic gas dissipating outwards and ensuring the accuracy of the moisture detection of the freeze-dried product in the cell; in addition, the cross cutout provided on the elastic sealing gasket can also ensure that the sample addition bottle or the dropper can be easily inserted into the titration cell of the Karl Fischer moisture detector for sample addition, and the cross cutout can be quickly rebounded and closed when the sample addition bottle or the dropper is withdrawn, thereby ensuring the sealing of the titration cell of the Karl Fischer moisture detector as much as possible and ensuring the safety of the Karl Fischer moisture detection operation of the freeze-dried product. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Figure 1 It is a structural diagram of the present utility model.

[0009] Figure 2 yes Figure 1 Schematic diagram of the longitudinal section. DETAILED DESCRIPTION

[0010] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0011] like Figure 1 、 2 As shown, the anti-evaporation device for the sample loading port of the titration cell for the Karl Fischer moisture test of freeze-dried products described in the present invention includes a sample loading channel 1 that can be inserted into the sample loading port 200 of the titration cell 100 of the Karl Fischer moisture tester. The sample loading channel 1 is composed of an upper cylindrical cavity 1.1 and a lower conical cavity 1.2.

[0012] Among them, the upper end of the cylindrical cavity 1.1 is sealed with an elastic sealing gasket 2, which is a silicone gasket or a rubber gasket. A cross cut 3 is opened at the center of the elastic sealing gasket 2. The horizontal and vertical lengths of the cross cut 3 are consistent, both 0.8~1.2cm, to ensure that the sample bottle or dropper can be easily inserted. At the same time, it can quickly rebound and close when the sample bottle or dropper is withdrawn, thereby ensuring its sealing as much as possible.

[0013] An annular baffle 4 is circumferentially arranged at the lower edge of the outer wall of the cylindrical cavity 1.1. The outer diameter of the annular baffle 4 should be larger than the caliber of the sample addition port 200 of the titration cell 100 of the Karl Fischer moisture detector. Its specific size can be determined according to the caliber of the sample addition port 200 to ensure that the annular baffle 4 can be stuck on the edge of the sample addition port 200, so that the entire sample addition channel 1 can be quickly inserted into the sample addition port 200 of the titration cell 100 of the Karl Fischer moisture detector.

[0014] A pressure cover 5 for further compressing the elastic sealing gasket 2 is screwed onto the outer wall of the cylindrical cavity 1.1 located above the annular baffle 4. A through hole 6 is opened at the center of the top wall of the pressure cover 5. Since the horizontal and vertical lengths of the cross cut 3 are 0.8~1.2cm, in order to fully expose the cross cut 3 on the elastic sealing gasket 2, the aperture of the through hole 6 is 1.3~1.6cm, and the through hole 6 is ensured to be coaxially aligned with the elastic sealing gasket 2.

[0015] When in use, the sample adding channel 1 is simply inserted into the sample adding port 200 of the titration cell 100 of the Karl Fischer moisture analyzer with the conical cavity 1.2 facing downwards. When adding sample to the titration cell 100 of the Karl Fischer moisture analyzer, the sample adding bottle (a common sample bottle for freeze-dried products is a 1ml sample adding bottle with a bottle mouth diameter of 1.2cm) or the dropper can overcome the elasticity of the elastic sealing gasket 2, causing the cross cut 3 to expand outwards, thereby easily passing through the cross cut 3 on the elastic sealing gasket 2 and extending into the titration cell 100 of the Karl Fischer moisture analyzer to add sample. When the sample adding bottle or the dropper is withdrawn, the sample adding bottle or the dropper can be inserted into the titration cell 100 of the Karl Fischer moisture analyzer to add sample. When the elastic sealing gasket 2 is closed, the cross cut 3 on the elastic sealing gasket 2 can rebound quickly under the action of its own elastic force and return to a closed posture, thereby ensuring the sealing of the titration cell 100 of the Karl Fischer moisture detector as much as possible, effectively blocking the gas generated by the volatilization of the toxic reagent in the titration cell 100 of the Karl Fischer moisture detector from diffusing outward, and at the same time effectively preventing outside air from entering the titration cell 100 of the Karl Fischer moisture detector, thereby avoiding the harm to the testing personnel caused by the evaporation of toxic gases, and ensuring the accuracy of the moisture detection of the freeze-dried product in the cell, thereby ensuring the safety of the Karl Fischer moisture detection operation of the freeze-dried product.

[0016] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present invention are only used to explain the relative position relationship, movement status, etc. between the various components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

Claims

1. A device for preventing evaporation of a sample port of a titration cell for Karl Fischer water content detection of freeze-dried products, characterized in that: The invention comprises a sample addition channel inserted into the sample addition port of the titration cell of a Karl Fischer moisture detector, wherein the sample addition channel consists of an upper cylindrical cavity and a lower conical cavity; an elastic sealing gasket with a cross cut in the middle is sealed at the upper end of the cylindrical cavity, an annular stop is circumferentially arranged at the lower edge of the outer wall of the cylindrical cavity to block the sample addition port, a pressure cover for pressing the elastic sealing gasket is screwed on the outer wall of the cylindrical cavity above the annular stop, and a through hole is opened in the center of the top wall of the pressure cover.

2. The anti-evaporation device for the sample port of the titration cell for Karl Fischer water content detection of freeze-dried products according to claim 1, characterized in that: The elastic sealing pad is a silicone pad or a rubber pad.

3. The anti-evaporation device for the sample port of the titration cell for Karl Fischer water content detection of freeze-dried products according to claim 1, characterized in that: The horizontal and vertical lengths of the cross cut are 0.8-1.2 cm, and the aperture of the through hole is 1.3-1.6 cm.

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