Ammonia detection device and ammonia detection system

Abstract

The utility model relates to an ammonia detection device and system, and the device comprises a first body which is used for bearing a sampling assembly, and the sampling assembly is used for bearing a to-be-detected liquid sample; the first driving assembly is located on the first body; the detection assembly is connected with the first driving assembly and comprises a second body, a first electrode and a detection unit, the second body is provided with a detection groove, the first electrode is located on the second body and located in the detection groove, the first electrode is doped with a detection reagent, and the detection unit is connected with the first electrode; under the condition that the first body bears the sampling assembly, the second body is used for moving under the driving of the first driving assembly and forming a detection cavity with the sampling assembly through the detection groove, and the first electrode is used for detecting liquid in the detection cavity according to a detection signal sent by the detection unit by utilizing a detection reagent to react with the liquid in the detection cavity. The detection unit is used for detecting a first electrical parameter of a reactant in the detection cavity and determining the ammonia concentration of the liquid sample according to the first electrical parameter. The ammonia detection device disclosed by the utility model is relatively low in cost.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical detection, in particular to an ammonia detection device and an ammonia detection system. BACKGROUND

[0002] Blood ammonia is a metabolic product produced by the liver in the process of protein metabolism, and is one of the commonly used protein metabolism product examination items in clinical practice. Normal human blood contains a small amount of free ammonia, which is a substance harmful to the human body. High blood ammonia can affect the function of neurons and the metabolism of nerve cells.

[0003] The blood ammonia detection device of the related art generally uses a single-wavelength reflection test method to detect the blood ammonia concentration, and such a blood ammonia detection device generally has a high cost. CONTENT OF THE INVENTION

[0004] Therefore, it is necessary to provide an ammonia detection device and an ammonia detection system with low cost in view of the above technical problems.

[0005] In a first aspect, the present application provides an ammonia detection device, which comprises:

[0006] A first body for carrying a sampling assembly, wherein the sampling assembly is used to carry a liquid sample to be detected;

[0007] A first driving assembly located on the first body;

[0008] A detection assembly connected with the first driving assembly, comprising a second body, a first electrode and a detection unit, wherein the second body is provided with a detection groove on a side close to the first body carrying the sampling assembly, the first electrode is located on the second body and in the detection groove, the first electrode is doped with a detection reagent, and the detection unit is connected with the first electrode; wherein

[0009] When the first body carries the sampling assembly, the second body is used to move under the driving of the first driving assembly and form a detection cavity with the sampling assembly through the detection groove, the first electrode is used to react the detection reagent with the liquid in the detection cavity according to the detection signal sent by the detection unit, and the detection unit is used to detect the first electrical property parameter of the reactant in the detection cavity and determine the ammonia concentration of the liquid sample according to the first electrical property parameter.

[0010] In one of the embodiments, the sampling assembly comprises a bottom plate, a whole blood hole, a plasma hole and a water absorption pad arranged on the bottom plate in sequence in the liquid flow direction, and a filter membrane for filtering plasma is arranged between the whole blood hole and the plasma hole;

[0011] The detection reagent includes polyaniline, wherein, in the case that the first body carries the sampling assembly, the second body is further used to move under the driving of the first driving assembly, the detection cavity is formed by the detection slot and the plasma hole, and the first electrode is used to generate the detection signal according to the redox reaction between the polyaniline and the plasma in the detection cavity.

[0012] In one of the embodiments, the detection assembly further includes a second electrode, which is located on the side of the second body close to the first body carrying the sampling assembly and is arranged in a spaced manner with the detection slot, and the second electrode is connected with the detection unit.

[0013] In the case that the first body carries the sampling assembly, the second electrode is used to move to contact with the water absorption pad under the driving of the first driving assembly, and the second electrical parameter of the water absorption pad is detected, and the detection unit is further used to generate the detection signal according to the second electrical parameter.

[0014] In one of the embodiments, the second body is provided with an access hole penetrating through the detection slot.

[0015] The first body is provided with a first storage cavity, and the first storage cavity is used to store a diluent.

[0016] The ammonia detection device further includes a second driving assembly, the first storage cavity is connected with the access hole, and the second driving assembly is connected with the detection unit, wherein the detection unit is further used to generate the first driving signal according to the second electrical parameter, so that the second driving assembly transmits the diluent in the first storage cavity to the detection cavity through the access hole according to the first driving signal, so as to dilute the liquid in the detection cavity.

[0017] The detection unit is further used to generate the detection signal in the case that the diluent entering the detection cavity reaches a preset liquid amount.

[0018] In one of the embodiments, the detection assembly further includes a gas pressure acquisition unit, which is located on the second body and connected with the detection slot, and the gas pressure acquisition unit is used to acquire the gas pressure information in the detection cavity; wherein,

[0019] The detection unit is further connected with the gas pressure acquisition unit, and the detection unit is further used to control the working state of the second driving assembly according to the gas pressure information, so as to adjust the liquid amount of the diluent in the detection cavity.

[0020] In one of the embodiments, the first body is further provided with a second storage cavity, and the second storage cavity is used to store a purifying substance.

[0021] The ammonia detection device further comprises a third driving assembly connected with the detection unit, and the third driving assembly is configured to, under the control of the detection unit, transmit the purifying substance in the second storage cavity to the detection cavity through the access hole to clean the detection cavity and the first electrode.

[0022] In one of the embodiments, the first body is further provided with a third storage cavity;

[0023] The ammonia detection device further comprises a fourth driving assembly connected with the detection unit, and the fourth driving assembly is configured to, under the control of the detection unit, discharge the reactant in the detection cavity to the third storage cavity through the access hole.

[0024] In one of the embodiments, the first driving assembly comprises:

[0025] A support structure is arranged on the side of the first body on which the sampling assembly is carried and is spaced apart from the detection area of the first body on which the sampling assembly is carried;

[0026] A moving arm is connected with the support structure, and the second body is arranged on the moving arm;

[0027] A driving unit is connected with the moving arm and is configured to drive the moving arm to move so as to drive the second body to move through the moving arm.

[0028] In one of the embodiments, the ammonia detection device further comprises a control module and a touch component arranged on the first body;

[0029] The control module is connected with the touch component and the first driving assembly, and the control module is configured to acquire a triggering instruction of the touch component and control the first driving assembly according to the triggering instruction so as to drive the second body to move through the first driving assembly.

[0030] In a second aspect, the present application further provides an ammonia detection system comprising the ammonia detection device and the sampling assembly according to any one of the embodiments.

[0031] The ammonia detection device and system include a first body for carrying a sampling assembly, a first driving assembly on the first body, and a detection assembly connected with the first driving assembly. The detection assembly includes a second body, a first electrode, and a detection unit. The second body is provided with a detection groove near a side of the first body carrying the sampling assembly. The first electrode is located on the second body and in the detection groove. The first electrode is doped with a detection reagent. The detection unit is connected with the first electrode. When the first body carries the sampling assembly, and the sampling assembly carries a liquid sample to be detected, the second body can be moved under the drive of the first driving assembly, so that the detection groove and the sampling assembly form a detection cavity. The first electrode in the detection groove can react with the liquid in the detection cavity by using the detection reagent according to the detection signal sent by the detection unit, so that the detection unit can detect the first electrical parameter of the reactant in the detection cavity, and determine the ammonia concentration of the liquid sample according to the first electrical parameter. The ammonia detection device in the present application can detect the liquid sample by using an electrochemical method, and has a lower cost than the detection device using a single-wavelength reflection test method in the related art. BRIEF DESCRIPTION OF DRAWINGS

[0032] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative effort.

[0033] Figure 1 Structure diagram of an ammonia detection device in an embodiment;

[0034] Figure 2 Structure diagram of a sampling assembly in an embodiment;

[0035] Figure 3 Structure diagram of an ammonia detection device in another embodiment;

[0036] Figure 4 Front structure diagram of a second body in an embodiment;

[0037] Figure 5 Top view structure diagram of a second body in an embodiment;

[0038] Figure 6 Structure diagram of an ammonia detection device in another embodiment;

[0039] Figure 7 Structure diagram of an ammonia detection device in another embodiment;

[0040] Figure 8Structure diagram of ammonia detection device in another embodiment;

[0041] Figure 9 Structure diagram of ammonia detection device in another embodiment;

[0042] Figure 10 Structure diagram of ammonia detection device in another embodiment;

[0043] Figure 11 Structure diagram of ammonia detection device in another embodiment;

[0044] Figure 12 Detection range diagram of ammonia detection device in an embodiment.

[0045] Explanation of reference numerals: 1-first body, 11-first storage cavity, 12-second storage cavity, 13-third storage cavity, 2-sampling assembly, 21-bottom plate, 22-whole blood hole, 23-plasma hole, 24-water absorption pad, 3-first driving assembly, 31-supporting structure, 32-moving arm, 4-detection assembly, 41-second body, 411-detection groove, 412-fixing cover, 413-sealing ring, 414-electrode groove, 415-inlet and outlet hole, 416-constant pressure hole, 42-first electrode, 43-detection unit, 44-second electrode, 45-air pressure acquisition unit, 51-second driving assembly, 52-third driving assembly, 53-fourth driving assembly, 61-display screen, 62-printing assembly, 63-power supply. DETAILED DESCRIPTION

[0046] In order to facilitate the understanding of the present application, the present application will be described more fully below with reference to the accompanying drawings. The embodiments of the present application are shown in the drawings. However, the present application can be implemented in many different forms, and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0047] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present application belongs. The terms used in the specification of the present application herein are only for the purpose of describing specific embodiments and are not intended to limit the present application.

[0048] It can be understood that the terms "first", "second", etc. used in the present application can be used herein to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish the first element from another element.

[0049] Spatially relative terms, such as "beneath", "below", "lower", "under", "above", "upper" and the like, can be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use and / or operation in addition to the orientations depicted in the figures. For example, if a device in the figures is inverted, elements described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Thus, the exemplary term "below" can encompass both an orientation of above and below. The devices can be otherwise oriented (e.g., rotated 90 degrees or at other orientations) and the spatial description terminology will be interpreted accordingly.

[0050] It is to be noted that when an element or layer is referred to as being "on" or "connected to" another element or layer, it can be directly on or connected to the other element or layer, or intervening elements or layers can be present. In addition, "connected" as used herein, if connected, means that there is either a direct electrical connection, or a wireless electrical connection, or a communication connection, between the objects connected.

[0051] As used herein, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. It should also be understood that the term "comprising" or "comprises" as used herein is not intended to exclude the presence of one or more additional elements, integers, steps, actions, components, parts or combinations thereof, unless the context clearly indicates otherwise. Also, the use of the term "and / or", includes any and all combinations of one or more of the associated listed items.

[0052] In one exemplary embodiment, the present application provides an ammonia detection device, which comprises a first body 1, a first driving assembly 3 and a detection assembly 4.

[0053] The first body 1 is used to carry the sampling assembly 2 used to carry the liquid sample to be detected. The first driving assembly 3 is located on the first body 1. The detection assembly 4 connected with the first driving assembly 3 includes a second body 41, a first electrode 42 and a detection unit 43. The second body 41 is provided with a detection groove 411 close to the side of the first body 1 carrying the sampling assembly 2. The first electrode 42 is located on the second body 41 and in the detection groove 411. The first electrode 411 is doped with a detection reagent. The detection unit 43 is connected with the first electrode 42. Wherein, under the condition that the first body 1 carries the sampling assembly 2, the second body 41 is used to move under the driving of the first driving assembly 3 and forms a detection cavity with the sampling assembly 2 through the detection groove 411. The first electrode 42 is used to react with the liquid in the detection cavity by using the detection reagent according to the detection signal sent by the detection unit 43. The detection unit 43 is used to detect the first electrical parameter of the reactant in the detection cavity and determine the ammonia concentration of the liquid sample according to the first electrical parameter.

[0054] It can be understood that the liquid sample to be detected can be a blood sample. When the blood sample is stored in the sampling assembly 2 and the sampling assembly 2 is stored on the first body 1, the first driving assembly 3 drives the second body 41 to move towards the first body 1 to make the detection groove 411 on the second body 41 form a detection cavity with the sampling assembly 2. The blood sample is located in the detection cavity. At this time, the blood sample in the detection cavity can be pretreated. For example, the blood sample can be diluted. After the blood sample is pretreated, the detection unit 43 can send a detection signal to the first electrode 42 in the detection cavity. The first electrode 42 can react with the pretreated blood sample in the detection cavity by using the detection reagent according to the detection signal. The detection unit 43 can detect the first electrical parameter in the reaction process of the detection reagent and the pretreated blood sample and determine the ammonia concentration of the blood sample according to the first electrical parameter. In application, the detection reagent doped on the first electrode can be polyaniline.

[0055] The ammonia detection device includes a first body for carrying the sampling assembly, a first driving assembly on the first body, and a detection assembly connected with the first driving assembly, the detection assembly including a second body, a first electrode, and a detection unit, the second body being provided with a detection groove near a side of the first body carrying the sampling assembly, the first electrode being located on the second body and in the detection groove, the first electrode being doped with a detection reagent, and the detection unit being connected with the first electrode. When the first body carries the sampling assembly, and the sampling assembly carries the liquid sample to be detected, the second body can be moved under the drive of the first driving assembly, so that the detection groove and the sampling assembly form a detection cavity, so that the first electrode in the detection groove can react with the liquid in the detection cavity by using the detection reagent according to the detection signal sent by the detection unit, so that the detection unit can detect the first electrical parameter of the reactant in the detection cavity, and determine the ammonia concentration of the liquid sample according to the first electrical parameter. The ammonia detection device in the application can detect the liquid sample by using an electrochemical method, and has a lower cost than the detection device using a single-wavelength reflection test method in the related art.

[0056] In one example embodiment, referring to Figure 2 The sampling assembly 2 includes a bottom plate 21, a whole blood hole 22, a plasma hole 23, and a water absorption pad 24 arranged on the bottom plate 21 in sequence according to the liquid flow direction, and a filter film for filtering plasma can be arranged between the whole blood hole 22 and the plasma hole 23, the detection reagent includes polyaniline, and in the case that the first body 1 carries the sampling assembly 2, the second body 41 is further used to move under the drive of the first driving assembly 3, a detection cavity is formed between the detection groove 411 and the plasma hole 23, and the first electrode 42 is used to cause an oxidation-reduction reaction between polyaniline and plasma in the detection cavity according to the detection signal.

[0057] In the embodiment, the blood sample can include whole blood and plasma. In one example, the first body 1 can be provided with a receiving groove for receiving the sampling assembly, and the bottom plate 21 can be provided with a positioning half-hole. A needle tube or other blood taking device can be used to take a drop (about 50ul) of blood and store it in the whole blood hole 22 in the sampling assembly 2. Then, the sampling assembly 2 can be placed in the receiving groove of the first body 1 according to the positioning half-hole. The needle tube or blood taking device can contain an anticoagulant, or the whole blood hole 22 can contain an anticoagulant. After the whole blood reacts with the anticoagulant, plasma, red blood cells, white blood cells and platelets are separated. A filter membrane for filtering plasma can be arranged between the whole blood hole 22 and the plasma hole 23, so that the red blood cells, white blood cells and platelets remain in the whole blood hole 22, and the plasma flows into the plasma hole 23 through the filter membrane. After the plasma flows into the plasma hole 23, the first driving assembly 3 can be controlled to drive the second body 41 to move towards the first body 1 until the detection groove 411 on the second body 41 is attached to the plasma hole 23 to form a detection cavity. Then, the plasma in the detection cavity can be pretreated, and the first electrode 42 can generate an oxidation-reduction reaction with the plasma in the detection cavity according to the detection signal.

[0058] In one embodiment, referring to Figure 3 , the detection assembly 4 further includes a second electrode 44, which is arranged on the side of the second body 41 close to the first body 1 carrying the sampling assembly 2 and is spaced apart from the detection groove 411. The second electrode 44 is connected with the detection unit 43. In the case that the first body 1 carries the sampling assembly 2, the second electrode 44 is used to move to contact the water-absorbing pad 24 under the driving of the first driving assembly 3, and detect a second electrical parameter of the water-absorbing pad 24. The detection unit 43 is further used to generate a detection signal according to the second electrical parameter.

[0059] Preferably, the first electrode 42 can generate an oxidation-reduction reaction with the plasma in the detection cavity according to the detection signal when the plasma in the plasma hole 23 is completely saturated, so that the detection unit 43 obtains a first electrical parameter. In the embodiment, the second electrode 44 can be arranged on the side of the second body 41 close to the first body 1 carrying the sampling assembly 2 and spaced apart from the detection groove 411. When the first driving assembly 3 drives the second body 41 to move towards the first body 1, the second electrode 44 can contact the water-absorbing pad 24 in the sampling assembly 2. The water-absorbing pad 24 can continuously absorb water in the plasma. The more water the water-absorbing pad 24 absorbs, the greater the value of the second electrical parameter detected by the second electrode 24. When the second electrical parameter reaches a preset threshold value, it can be determined that the plasma in the plasma hole 23 is completely saturated. The detection unit 43 can send a detection signal to the first electrode 42 according to the second electrical parameter. It can be understood that the second electrode 44 can be one of a capacitance detection electrode or a resistance detection electrode, and accordingly, the second electrical parameter can be capacitance or resistance.

[0060] In the application, the two sides of the plasma hole 23 of the sampling assembly 2 can also be provided with a cutting hole, and the second body can be provided with a cutting unit at the position corresponding to the cutting hole on the two sides of the detection groove. When the second electrical parameter reaches the preset threshold value, that is, when the plasma in the plasma hole 23 is completely saturated, the cutting unit can be controlled to cut the cutting hole of the sampling assembly 2, so as to cut the flow path between the whole blood hole 22 and the plasma hole 23 and between the plasma hole 23 and the water absorption pad 24, thereby avoiding the flow of plasma to the water absorption pad 24. In addition, when the second electrode 44 is a capacitance detection electrode, a plastic sealing layer can also be arranged on the side of the water absorption pad 24 away from the bottom plate, so that the second electrode 44 is in contact with the water absorption pad 24, thereby prolonging the service life of the second electrode.

[0061] In one embodiment, please refer to Figure 4 and Figure 5 , Figure 4 the front structure diagram of the second body 41, Figure 5 the top view of the second body 41, in addition to the detection groove 411, the second body 41 also includes a fixing cover 412 and a sealing ring 413 arranged outside the detection groove, the second body 41 is suitable for being detachably connected with the first driving assembly 3 through the fixing cover 412, and the detection groove 411 can be sealed and attached to the plasma hole 23 through the sealing ring 413. The second body 41 also includes an electrode groove 414 for mounting the first electrode 42 and an access hole 415 penetrating the detection groove.

[0062] In one embodiment, please refer to Figure 6 , the first body 1 can be provided with a first storage cavity 11 inside, the first storage cavity 11 is used for storing diluent, and the ammonia detection device also includes a second driving assembly 51, the first storage cavity 11 is connected with the access hole 415 through the second driving assembly 51, and the second driving assembly 51 is connected with the detection unit 43, wherein the detection unit 43 is also used for generating a first driving signal according to the second electrical parameter, so that the second driving assembly 51 transmits the diluent in the first storage cavity 11 to the detection cavity through the access hole 415 according to the first driving signal, so as to dilute the liquid in the detection cavity. The detection unit 43 is used for generating a detection signal when the diluent entering the detection cavity reaches a preset liquid inlet amount.

[0063] In one example, when the detection groove 411 on the second body 41 is combined with the plasma hole 23 to form a detection cavity, and the second electrode 24 detects that the second electrical parameter reaches a preset threshold, the detection unit 43 can send a first driving signal to the second driving assembly 51 to drive the diluent in the first storage cavity 11 into the detection cavity to dilute the plasma. When the diluent in the detection cavity reaches a preset liquid amount, the detection unit 43 can send a detection signal to the first electrode 42 to make the first electrode 42 use polyaniline to have an oxidation-reduction reaction with the plasma in the detection cavity. The second driving assembly 51 can include a driving pump and a control valve.

[0064] In one embodiment, referring to Figure 7 The detection assembly 4 further includes an air pressure acquisition unit 45, which can be located on the second body 41 and connected with the detection groove 411. The air pressure acquisition unit 45 is used to acquire air pressure information in the detection cavity. The detection unit 43 is further connected with the air pressure acquisition unit 45, and the detection unit 43 is further used to control the working state of the second driving assembly 54 according to the air pressure information, so as to adjust the liquid amount of the diluent in the detection cavity.

[0065] Please continue to refer to Figure 5 The second body 41 can further be provided with a constant pressure hole 416 penetrating the detection groove 411, and the air pressure acquisition unit 45 can be connected with the detection groove 411 through the constant pressure hole 416 to detect the air pressure information in the detection cavity. It can be understood that, in order to ensure the accuracy of the blood ammonia detection result, the liquid amount of the diluent needs to be accurately controlled when the first driving assembly 51 drives the diluent in the first storage cavity 11 into the detection cavity. However, the driving pump in the related technology often cannot reach the accuracy of microliters. Therefore, the air pressure acquisition unit 45 is arranged in the present application to detect the air pressure information in the detection cavity in real time, and the detected air pressure information is fed back to the detection unit 43 in real time, so that the detection unit 43 adjusts the working state of the first driving assembly 51 according to the air pressure information in the detection cavity, thereby adjusting the liquid amount of the diluent. Specifically, the detection unit 43 can adjust the working frequency of the driving pump in the air pressure acquisition unit 45 and / or the opening degree of the control valve in the air pressure acquisition unit 45.

[0066] In application, the first body 1 can further be provided with a gas storage cavity connected with the detection groove 411 through the constant pressure hole 416. When the diluent enters the detection cavity, part of the original air in the detection cavity can be discharged to the gas storage cavity through the constant pressure hole 416. Since the volume of the gas storage cavity is constant, when the air enters the gas storage cavity, the ammonia gas volatilized from the plasma will be repelled into the gas storage cavity, so that the ammonia gas remains in the detection cavity and prevents the ammonia in the plasma from continuing to volatilize, thereby improving the accuracy of the blood ammonia detection.

[0067] In one embodiment, referring toFigure 8 Figure 8 The first body 1 further comprises a second storage cavity 12 for storing a purifying substance, and the ammonia detection device further comprises a third driving assembly 52 connected with the detection unit 53, and the third driving assembly 52 is configured to, under the control of the detection unit 43, transmit the purifying substance in the second storage cavity 12 to the detection cavity through the access hole 415 to clean the detection cavity and the first electrode 42.

[0068] It can be understood that the purifying substance can be a cleaning liquid. After the blood ammonia detection is completed, the diluted blood plasma in the detection cavity can be discharged, and the cleaning liquid in the second storage cavity 12 can be transmitted to the detection cavity through the access hole 415 by the third driving assembly to clean the detection cavity. In an application, an oscillator can be arranged on the inner wall of the detection groove 411, and the oscillator is connected with the detection unit 43. When the cleaning liquid enters the detection cavity, the detection unit 43 controls the oscillator to work to improve the cleaning efficiency of the detection cavity. In one example, the second driving assembly 51 and the third driving assembly 52 can each use a one-way valve. In another example, the second driving assembly 51 and the third driving assembly 52 can share a three-way valve.

[0069] In one embodiment, please refer to Figure 9 Figure 9 The first body further comprises a third storage cavity 13, and the ammonia detection device further comprises a fourth driving assembly 53 connected with the detection unit 43, and the fourth driving assembly 53 is configured to, under the control of the detection unit 43, discharge the reaction substance in the detection cavity to the third storage cavity 13 through the access hole.

[0070] It can be understood that after the blood ammonia detection is completed or the detection cavity is cleaned, the waste liquid needs to be discharged from the detection cavity, and therefore a third storage cavity 13 can be arranged to accommodate the discharged waste liquid. The fourth driving assembly 53 can comprise a driving pump and a control valve.

[0071] In one embodiment, please refer to Figure 10 and Figure 11 , Figure 10 is a side view structural schematic diagram of the ammonia detection device, Figure 11 is a top view structural schematic diagram of the ammonia detection device. The first driving assembly 3 can comprise a support structure 31, a moving arm 32, and a driving unit.

[0072] ​​The support structure 31 is located on one side of the first body carrying the sampling assembly 2 and is spaced apart from the detection area of the first body 1 carrying the sampling assembly 2. The moving arm 32 is connected with the support structure 31, wherein the second body 41 is located on the moving arm, and a driving unit is connected with the moving arm 32 for driving the moving arm 32 to move to drive the second body 41 through the moving arm 32.

[0073] The ammonia detection device further comprises a display screen 61, a printing assembly 62, a power supply 63, a control module and a touch component located on the first body 1. The control module is connected with the touch component and the first driving assembly 3 respectively, and is used for obtaining a triggering instruction of the touch component by a user and controlling the first driving assembly 3 according to the triggering instruction to drive the second body 41 to move through the first driving assembly 3.

[0074] In a detailed embodiment, the display screen 61 can be located on the first body 1, and the touch component can be a touch button on the display screen. When the sampling assembly 2 is placed in the accommodating groove on the first body 1 and the plasma flows into the plasma hole 23, the user can press the touch component to make the control module control the first driving assembly 3 to drive the second body 41 to move according to the triggering instruction until the detection groove 411 on the second body 41 is attached to the plasma hole 23 to form a detection cavity. At the same time, the second electrode 44 can be in contact with the water absorption pad 24 and detect the second electrical parameter of the water absorption pad 24, and when the second electrical parameter reaches a preset threshold value, it can be determined that the plasma in the plasma hole 23 is completely saturated by liquid. The detection unit 43 can generate a first driving signal according to the second electrical parameter to make the second driving assembly 51 transmit the diluent in the first storage cavity 11 to the detection cavity through the inlet and outlet hole 415 to dilute the liquid in the detection cavity. In the process of driving the diluent into the detection cavity by the second driving assembly 51, the gas pressure acquisition unit 45 can detect the gas pressure information in the detection cavity through the constant pressure hole 416, and make the detection unit 43 adjust the working state of the first driving assembly 51 according to the gas pressure information in the detection cavity, and further adjust the liquid inlet amount of the diluent to ensure the accuracy of the liquid inlet amount of the diluent. When the diluent entering the detection cavity reaches a preset liquid inlet amount, the detection unit 43 can send a detection signal to the first electrode 42 to make the first electrode 42 use polyaniline to have an oxidation-reduction reaction with the diluted plasma in the detection cavity.

[0075] The detection signal can include an alternating current signal and at least a direct current signal, and the first electrical parameter can be the charge transfer impedance in the oxidation-reduction reaction process of the first electrode 42 using polyaniline and the plasma in the detection cavity. The charge transfer impedance is related to the ammonia concentration in the plasma, and the detection unit 43 can obtain the charge transfer impedance and determine the ammonia concentration in the plasma according to the preset relationship to obtain the blood ammonia detection result. In application, the blood ammonia detection result can be displayed through the display screen 61 and / or printed through the printing assembly 62.

[0076] After the blood ammonia detection is completed, the diluted blood plasma in the detection cavity can be discharged into the third storage cavity 13 through the third driving assembly 52, and the cleaning liquid in the second storage cavity 12 can be transmitted to the detection cavity through the inlet and outlet hole 415 through the third driving assembly to clean the detection cavity. During the cleaning process, the oscillator on the inner wall of the detection groove 411 can be turned on to improve the cleaning efficiency. After the cleaning is completed, the used cleaning liquid in the detection cavity can be discharged to the third storage cavity 13 through the inlet and outlet hole. Finally, the user can press the touch component again to make the control module control the first driving assembly 3 to drive the second body 41 to move away from the first body 1 in the direction until it returns to the home position. The user takes out the sampling assembly 2, and the detection process is completed.

[0077] In one embodiment, the overall volume of the ammonia detection device of the present application is about 150x90x60mm.

[0078] In one embodiment, please refer to Figure 12 , Figure 12 is a schematic diagram of the blood ammonia detection range of the ammonia detection device of the present application, wherein the abscissa is the blood ammonia concentration, and the ordinate is the area of the oxidation peak and the reduction peak in the blood ammonia detection process. It can be seen that the blood ammonia detection range can be 0-200uM. In one example, the blood ammonia detection range can be 0-5mM, and the 0-5mM range can be achieved by increasing the diluent.

[0079] In one embodiment, the present application also provides an ammonia detection system comprising the ammonia detection device of any one of the above embodiments and the sampling assembly.

[0080] In the description of the present specification, the description of the terms "some embodiments", "other embodiments", "ideal embodiments" and the like means that the specific features, structures, materials or characteristics described in conjunction with the embodiments or examples are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example.

[0081] The technical features of the above embodiments can be combined arbitrarily. In order to make the description simple, not all possible combinations of the technical features in the above embodiments are described, however, as long as the combination of the technical features does not exist contradictory, it should be considered as the scope of the present specification.

[0082] The above embodiments only express several implementation manners of the application, and the description is relatively specific and detailed, but it should not be understood as a limitation on the scope of the utility model patent. It should be pointed out that for ordinary skilled persons in the art, without departing from the concept of the application, a number of modifications and improvements can be made, which all belong to the protection scope of the application. Therefore, the protection scope of the patent of the application should be subject to the appended claims.

Claims

1. An ammonia detecting device, characterized by comprising: The device comprises: a first body for carrying a sampling assembly for carrying a liquid sample to be detected; a first driving assembly on the first body; a detection assembly connected with the first driving assembly, comprising a second body, a first electrode and a detection unit, the second body is provided with a detection groove on a side close to the first body carrying the sampling assembly, the first electrode is located on the second body and in the detection groove, the first electrode is doped with a detection reagent, and the detection unit is connected with the first electrode; wherein, when the first body carries the sampling assembly, the second body is used to move under the driving of the first driving assembly and forms a detection cavity with the sampling assembly through the detection groove, the first electrode is used to react with the liquid in the detection cavity by using the detection reagent according to the detection signal sent by the detection unit, and the detection unit is used to detect a first electrical parameter of the reactant in the detection cavity and determine the ammonia concentration of the liquid sample according to the first electrical parameter.

2. The ammonia detection device of claim 1, wherein The sampling assembly comprises a bottom plate, a whole blood hole, a plasma hole and a water absorption pad arranged on the bottom plate in sequence according to the liquid flow direction, and a filter membrane for filtering plasma is arranged between the whole blood hole and the plasma hole; The detection reagent comprises polyaniline, wherein, when the first body carries the sampling assembly, the second body is also used to move under the driving of the first driving assembly and forms the detection cavity with the plasma hole through the detection groove, and the first electrode is used to oxidize and reduce the plasma in the detection cavity by using the polyaniline according to the detection signal.

3. The ammonia detection device of claim 2, wherein, The detection assembly further comprises a second electrode, which is located on the side of the second body close to the first body carrying the sampling assembly and is arranged in a spaced manner with the detection groove, and the second electrode is connected with the detection unit; When the first body carries the sampling assembly, the second electrode is used to move to contact with the water absorption pad under the driving of the first driving assembly and detect a second electrical parameter of the water absorption pad, and the detection unit is also used to generate the detection signal according to the second electrical parameter.

4. The ammonia detection device of claim 3, wherein The second body is provided with an access hole penetrating through the detection groove; The first body is provided with a first storage cavity for storing a diluent; The ammonia detection device further comprises a second driving assembly, the first storage cavity is connected with the access hole, and the second driving assembly is connected with the detection unit, wherein the detection unit is also used to generate a first driving signal according to the second electrical parameter, so that the second driving assembly transmits the diluent in the first storage cavity to the detection cavity through the access hole according to the first driving signal to dilute the liquid in the detection cavity; The detection unit is also used to generate the detection signal when the diluent entering the detection cavity reaches a preset liquid amount.

5. The ammonia detection device of claim 4, wherein The detection assembly further comprises an air pressure acquisition unit, which is located on the second body and connected with the detection groove, and is used to acquire air pressure information in the detection cavity. The detection unit is further connected with the air pressure acquisition unit, and is further used to control the working state of the second driving assembly according to the air pressure information, so as to adjust the liquid inflow amount of the dilution liquid in the detection cavity.

6. The ammonia detection device of claim 4, wherein The first body is further provided with a second storage cavity, which is used to store purifying substances; The ammonia detection device further comprises a third driving assembly, which is connected with the detection unit, and is used to transmit the purifying substances in the second storage cavity to the detection cavity through the access hole under the control of the detection unit, so as to clean the detection cavity and the first electrode.

7. The ammonia detection device of claim 4, wherein The first body is further provided with a third storage cavity; The ammonia detection device further comprises a fourth driving assembly, which is connected with the detection unit, and is used to discharge the reactants in the detection cavity to the third storage cavity through the access hole under the control of the detection unit.

8. The ammonia detection device of claim 1, wherein, The first driving assembly comprises: A support structure is located on one side of the first body bearing the sampling assembly, and is arranged in a spaced manner with a detection area of the first body bearing the sampling assembly; A moving arm is connected with the support structure, wherein the second body is located on the moving arm; A driving unit is connected with the moving arm, and is used to drive the moving arm to move, so as to drive the second body through the moving arm.

9. The ammonia detection device of claim 1, wherein, The ammonia detection device further comprises a control module and a touch component located on the first body; The control module is connected with the touch component and the first driving assembly respectively, and is used to acquire a trigger instruction of the touch component by a user, and to control the first driving assembly according to the trigger instruction, so as to drive the second body to move through the first driving assembly.

10. An ammonia detection system characterized by, The ammonia detection device and the sampling assembly as claimed in any one of claims 1-9 are included. The ammonia detection device and the sampling assembly as claimed in any one of claims 1-9 are included.

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