Dead-corner-free tank bottom valve for fusidic acid production fermentation tank

Abstract

The utility model discloses a dead-corner-free tank bottom valve for a fusidic acid production fermentation tank, which relates to the technical field of fermentation engineering and comprises a fermentation tank body, a sanitary hoop joint is integrally formed at the bottom of the fermentation tank body, and the bottom of the sanitary hoop joint is connected with a dead-corner-free diaphragm valve through a hoop device; according to the utility model, the smooth inner wall of the arc-shaped elbow is tightly matched with the spherical valve core and the diaphragm piece, so that material residues are effectively prevented. In the actual production process, compared with multi-batch operation, when a traditional valve is used, a certain amount of materials are left in the valve after each fermentation, a large amount of time and resources need to be consumed for cleaning, the materials are difficult to thoroughly clean, and pollution is easily caused to next-batch fermentation. And by adopting the dead-corner-free tank bottom valve, almost no material residue exists, the purity of the fermentation raw material is obviously improved, a solid foundation is laid for producing high-purity and high-quality fusidic acid products, and the stability and the consistency of the product quality are ensured.

Description

Technical Field

[0001] This utility model relates to the field of fermentation engineering technology, and in particular to a bottom valve without dead angle for a fermenter used in the production of fusidic acid. Background Technology

[0002] In the production of fusidic acid, the fermenter is one of the key pieces of equipment, and the bottom valve of the fermenter plays a vital role in ensuring the smooth progress of the entire fermentation process and the quality of the product.

[0003] Currently, traditional bottom valves used in fermenters have many drawbacks. Existing bottom valves are typically connected to the tank body via a threaded pipe. This connection method creates areas between the valve and the tank body that are difficult to thoroughly clean and disinfect—so-called "dead zones." In fusidic acid production, fermenters require regular and rigorous disinfection procedures to prevent contamination by other microorganisms that could affect product quality. However, due to these dead zones, chemical disinfectants cannot fully reach and act on these areas during disinfection, easily leading to material accumulation. This accumulation not only breeds bacteria and microorganisms but can also contaminate the product during subsequent fermentation, severely impacting the purity and quality of fusidic acid. Moreover, even with increased disinfection time and disinfectant dosage, it is difficult to ensure that these dead zones achieve the same disinfection effect as other areas, always carrying the risk of incomplete disinfection and introducing significant uncertainty into product quality.

[0004] Furthermore, the flow channel design of traditional tank bottom valves is often inadequate, and the complex flow channel structure can easily lead to material residue and accumulation during material transport. The fusidic acid fermentation process involves complex material components, including culture media, microbial cells, and metabolites, some of which have a certain degree of viscosity or particulate matter. When flowing through the valve channel, these materials easily adhere to the channel walls, gradually accumulating over time. This not only reduces the effective cross-sectional area of ​​the channel, affecting normal material transport and causing unstable flow rates, but can also become a breeding ground for bacteria, further contaminating the fermentation environment and adversely affecting fusidic acid production. Simultaneously, material residue and accumulation increase the difficulty and frequency of cleaning, reducing production efficiency and increasing production costs.

[0005] Therefore, there is an urgent need for a new type of tank bottom valve to solve these problems in the existing technology, so as to meet the strict requirements of fusidic acid production for the tank bottom valve of the fermentation tank in terms of cleaning, disinfection, material conveying and quality control. Utility Model Content

[0006] This invention provides a bottom valve for fusidic acid production fermenters without dead angles, solving the technical problem of sanitary dead angles between the valve and the tank body.

[0007] To solve the above-mentioned technical problems, this utility model provides a dead-angle-free tank bottom valve for a fusidic acid production fermenter, including a fermenter body. A sanitary clamp joint is integrally formed at the bottom of the fermenter body. A dead-angle-free diaphragm valve is connected to the bottom of the sanitary clamp joint through a clamp device. The dead-angle-free diaphragm valve includes an arc-shaped elbow. A connecting cover is integrally formed at one end of the arc-shaped elbow, and a connector is integrally formed at the other end of the arc-shaped elbow. A connecting branch pipe is provided on the side of the arc-shaped elbow. A spherical valve core is movably installed in the connecting branch pipe. A diaphragm is provided on the inner wall of the arc-shaped elbow, and the spherical valve core is fixedly connected to the diaphragm.

[0008] In some embodiments, a clamping flange is integrally formed on the side edge of the connecting cover, and a tapered guide groove is provided in the middle of the connecting cover.

[0009] In some embodiments, the connecting branch pipe is disposed on the outer arc surface of the arc-shaped bend, and the diaphragm is disposed on the inner side of the outer arc surface of the arc-shaped bend.

[0010] In some embodiments, one end of the connecting branch pipe is provided with a control cylinder, and a piston is movably installed inside the control cylinder. The piston divides the inside of the control cylinder into two cavities, and the two cavities are respectively provided with a first air hole and a second air hole on their sides.

[0011] In some embodiments, a connecting rod is fixedly mounted on one side of the piston, and one end of the connecting rod is fixedly connected to the diaphragm.

[0012] In some embodiments, a position indicator is fixedly mounted on the other side of the piston, with one end of the position indicator protruding from the surface of the control cylinder.

[0013] In some embodiments, sealing rings are provided between the connecting rod and the inner wall of the control cylinder, between the piston and the inner wall of the control cylinder, and between the indicator rod and the inner wall of the control cylinder.

[0014] Compared with related technologies, the dead-angle-free tank bottom valve for fusidic acid production fermenters provided by this utility model has the following beneficial effects:

[0015] This invention provides a bottom-mounted valve without dead angles for fermenters used in fusidic acid production. Through the smooth inner wall of the arc-shaped elbow and the tight fit between the spherical valve core and the diaphragm, material residue is effectively prevented. In actual production, after comparing multiple batches, it was found that with traditional valves, a certain amount of material remained inside the valve after each fermentation, requiring significant time and resources for cleaning, and was difficult to completely remove, easily contaminating the next batch of fermentation. However, with this bottom-mounted valve without dead angles, there is almost no material residue, significantly improving the purity of the fermentation raw materials. This lays a solid foundation for producing high-purity, high-quality fusidic acid products, ensuring the stability and consistency of product quality. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of this utility model when installed at the bottom of a fermentation tank;

[0017] Figure 2 This is a schematic diagram of the dead-angle-free diaphragm valve structure of this utility model;

[0018] Figure 3 This is a schematic diagram of the cross-sectional structure of the diaphragm valve with no dead angle when it is half open according to this utility model;

[0019] Figure 4 This is a schematic diagram of the cross-sectional structure of the dead-angle-free diaphragm valve of this utility model when the valve is closed;

[0020] Figure 5 This is a schematic cross-sectional view of the diaphragm valve with no dead angle when it is fully open.

[0021] Labels in the diagram: 1. Fermentation tank body; 2. Sanitary clamp joint; 3. Clamp device; 4. Diaphragm valve with no dead angle; 41. Arc-shaped elbow; 42. Connecting cover; 43. Clamp connecting flange; 44. Conical guide groove; 45. Connector; 46. Connecting branch pipe; 47. Control cylinder; 461. Spherical valve core; 462. Diaphragm; 471. Piston; 472. Connecting rod; 473. Indicator rod; 474. First vent; 475. Second vent. Detailed Implementation

[0022] Example 1

[0023] This embodiment provides a bottom valve without dead angles for a fusidic acid production fermenter, such as... Figure 1-5As shown, this utility model includes a fermenter body 1. A sanitary clamp connector 2 is integrally formed at the bottom of the fermenter body 1. The bottom of the sanitary clamp connector 2 is connected to a dead-angle-free diaphragm valve 4 via a clamp device 3. The dead-angle-free diaphragm valve 4 includes an arc-shaped elbow 41. A connecting cover 42 is integrally formed at one end of the arc-shaped elbow 41, and a connector 45 is integrally formed at the other end of the arc-shaped elbow 41. A connecting branch pipe 46 is provided on the side of the arc-shaped elbow 41. A spherical valve core 461 is movably installed in the connecting branch pipe 46. A diaphragm sheet 462 is provided on the inner wall of the arc-shaped elbow 41. The spherical valve core 461 is fixedly connected to the diaphragm sheet 462. A clamp connecting flange 43 is integrally formed on the side edge of the connecting cover 42, and a conical guide groove 44 is provided in the middle of the connecting cover 42. A connecting branch pipe 46 is located on the outer arc surface of the curved elbow 41, and a diaphragm 462 is located on the inner side of the outer arc surface of the curved elbow 41. A control cylinder 47 is located at one end of the connecting branch pipe 46. A piston 471 is movably mounted inside the control cylinder 47, dividing the interior of the control cylinder 47 into two chambers. The two chambers have a first vent 474 and a second vent 475 on their sides, respectively. A connecting rod 472 is fixedly mounted on one side of the piston 471, and one end of the connecting rod 472 is fixedly connected to the diaphragm 462. A position indicator rod 473 is fixedly mounted on the other side of the piston 471, with one end protruding from the surface of the control cylinder 47. Sealing rings are provided between the connecting rod 472 and the inner wall of the control cylinder 47, between the piston 471 and the inner wall of the control cylinder 47, and between the position indicator rod 473 and the inner wall of the control cylinder 47.

[0024] In the fermentation production of fusidic acid, traditional bottom valves, due to their unreasonable structural design, are prone to leaving material residue inside the valve. This residue not only affects the quality of the next batch of fermentation but may also breed bacteria, leading to contamination of the fermentation broth and seriously affecting the purity and efficacy of fusidic acid.

[0025] In this embodiment, the sanitary clamp joint 2 integrally formed at the bottom of the fermenter body 1 is tightly connected to the dead-angle-free diaphragm valve 4 via a clamp device 3. This connection method reduces the gaps at the connection points of traditional valves, lowering the possibility of material residue. The arc-shaped elbow 41 design in the dead-angle-free diaphragm valve 4 is crucial. Its smooth arc-shaped inner wall has no dead corners, allowing material to flow smoothly through the valve and preventing accumulation. Furthermore, when the material passes through the diaphragm plate 462, it also washes the surface of the diaphragm plate 462, further ensuring that the material does not accumulate. The spherical valve core 461, which is movably installed in the connecting branch pipe 46, fits tightly with the diaphragm plate 462 on the inner wall of the arc-shaped elbow 41. When the valve is closed, the spherical valve core 461 squeezes the diaphragm plate 462, allowing the diaphragm plate 462 to completely conform to the inner wall of the arc-shaped elbow 41, forming a reliable seal while ensuring that no material remains near the sealing surface.

[0026] Example 2

[0027] Fermentation production has extremely high hygiene requirements, and microbial contamination is a serious problem in the fermentation process. Traditional tank bottom valves, due to the presence of areas that are difficult to thoroughly clean and disinfect, easily become breeding grounds for bacteria. During fermentation, bacteria may enter the fermenter, leading to fermentation failure, product spoilage, and huge economic losses.

[0028] In this embodiment, the sanitary clamp connector 2 is designed to ensure the hygiene of the connection points. Its smooth surface and excellent sealing performance prevent bacteria from hiding and multiplying at the joint. The diaphragm valve 4, with its simple overall structure and lack of complex internal grooves or gaps, is easy to clean and disinfect. The conical guide groove 44 in the middle of the connecting cover 42 not only facilitates the smooth flow of materials but also allows the cleaning solution and disinfectant to better cover the inner surface of the valve during cleaning and disinfection. During disinfection, high-temperature steam or disinfectant solution is passed through the valve. Due to the valve's dead-angle-free design, the steam or disinfectant can fully contact every part of the valve, achieving comprehensive disinfection.

[0029] Example 3

[0030] During fusidic acid fermentation, strict control of the fermentation broth flow rate is required at different stages. For example, the nutrient feeding rate needs to be precisely controlled in the early stage of fermentation, and the aeration rate and circulating broth flow rate need to be adjusted according to the microbial growth status during fermentation. Traditional valves often cannot achieve precise flow regulation, leading to instability in the fermentation process and affecting the yield and quality of fusidic acid.

[0031] In this embodiment, the dead-angle-free bottom valve achieves precise flow control through the coordinated operation of components such as the connecting branch pipe 46, the ball valve core 461, and the control cylinder 47. Inside the control cylinder 47, the piston 471, under the action of compressed gas, moves the connecting rod 472 and the ball valve core 461. By changing the position of the ball valve core 461 within the connecting branch pipe 46, the cross-sectional area of ​​the channel within the arc-shaped bend 41 is precisely adjusted. The piston 471 divides the interior of the control cylinder 47 into two chambers, each with a first air hole 474 and a second air hole 475 on its side. By precisely controlling the pressure and flow rate of the compressed gas entering the two chambers, the position of the piston 471 can be precisely adjusted, thereby achieving precise control of the valve flow rate.

[0032] Example 4

[0033] The fermentation process of fusidic acid involves complex and variable operating conditions. For example, the fermentation broth may be corrosive, and the temperature and pressure inside the fermenter may fluctuate within a certain range. Traditional valves are prone to corrosion, sealing failure, and component deformation under these complex conditions, which affects their service life and reliability, and increases the frequency of equipment replacement and maintenance.

[0034] In this embodiment, the main bodies of the fermenter body 1, the sanitary clamp joint 2, and the dead-angle-free diaphragm valve 4 are made of 316L stainless steel with excellent corrosion resistance, effectively resisting the corrosion of the fermentation liquid. The diaphragm 462 is made of rubber or polymer material with good corrosion resistance and flexibility, ensuring that it will not be corroded or damaged under long-term contact with the fermentation liquid, while maintaining good sealing performance. The arc-shaped elbow 41 is designed to withstand pressure fluctuations within a certain range. Its arc-shaped structure can evenly distribute pressure, reduce stress concentration points, and prevent component deformation.

Claims

1. A bottom valve for a fusidic acid production fermenter with no dead angle, comprising a fermenter body, wherein a sanitary clamp connector is integrally formed at the bottom of the fermenter body, characterized in that: The bottom of the sanitary clamp connector is connected to a diaphragm valve with no dead angle via a clamp device; The dead-angle-free diaphragm valve includes an arc-shaped elbow, one end of which is integrally formed with a connecting cover, and the other end of which is integrally formed with a connector. A connecting branch pipe is provided on the side of the arc-shaped elbow, and a spherical valve core is movably installed in the connecting branch pipe. A diaphragm is provided on the inner wall of the arc-shaped elbow, and the spherical valve core is fixedly connected to the diaphragm.

2. The bottom valve without dead angle for a fusidic acid production fermenter according to claim 1, characterized in that, The side edge of the connecting cover is integrally formed with a clamp connecting flange, and the middle part of the connecting cover is provided with a tapered guide groove.

3. The bottom valve without dead angle for a fusidic acid production fermenter according to claim 1, characterized in that, The connecting branch pipe is located on the outer arc surface of the curved bend, and the diaphragm is located on the inner side of the outer arc surface of the curved bend.

4. A bottom valve without dead angle for a fusidic acid production fermenter according to claim 1, characterized in that, One end of the connecting branch pipe is provided with a control cylinder, and a piston is movably installed inside the control cylinder. The piston divides the inside of the control cylinder into two cavities, and the two cavities are respectively provided with a first air hole and a second air hole on their sides.

5. A bottom valve without dead angle for a fusidic acid production fermenter according to claim 4, characterized in that, A connecting rod is fixedly installed on one side of the piston, and one end of the connecting rod is fixedly connected to the diaphragm.

6. A bottom valve without dead angle for a fusidic acid production fermenter according to claim 5, characterized in that, A position indicator rod is fixedly installed on the other side of the piston, and one end of the position indicator rod protrudes from the surface of the control cylinder.

7. A bottom valve without dead angle for a fusidic acid production fermenter according to claim 6, characterized in that, Sealing rings are provided between the connecting rod and the inner wall of the control cylinder, between the piston and the inner wall of the control cylinder, and between the indicator rod and the inner wall of the control cylinder.

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