Film making, dyeing, sealing and reading all-in-one machine

Abstract

The utility model discloses an all-in-one machine for slide preparation, dye sealing and slide reading, which relates to the technical field of liquid-based cell detection and comprises a rack, a slide preparation system, a dye sealing system, a slide reading system and a transfer system, the flaking system comprises a pretreatment module and a flaking module, the pretreatment module is provided with an oscillation cavity, and the flaking module is provided with a pipettor and a centrifugal groove; the dyeing and packaging system is used for dyeing and packaging the sample; the film reading system is used for reading the packaged sample; the transfer system comprises a first transfer device and a second transfer device, the first transfer device is arranged between the slide preparation system and the dyeing and sealing system and used for transferring the centrifuged samples to the dyeing and sealing system, and the second transfer device is arranged between the dyeing and sealing system and the slide reading system and used for transferring the packaged samples to the slide reading system. According to the technical scheme provided by the utility model, the automation degree of film preparation, dye sealing and film reading is improved, the inspection efficiency is improved, the labor cost is reduced, and the data binding accuracy is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to tablet making technical field, especially a tablet making, dyeing and sealing and reading film integrated machine. BACKGROUND

[0002] The exfoliative cytology is a method for diagnosing by using normal exfoliative cells of human body, and the liquid-based cytology is a part of the exfoliative cytology, which is to put the exfoliative cytology specimen which is difficult to handle in a traditional way into an intermediate liquid to remove blood, mucus and other interference components affecting diagnosis, so as to improve the diagnostic efficiency. Compared with the traditional cervical scraping Papanicolaou smear examination, the liquid-based cytology examination significantly improves the specimen satisfaction and the detection rate of abnormal cervical cells.

[0003] The liquid-based cytology examination usually includes the steps of tablet making, dyeing, packaging, reading film and the like. At present, the tablet making is usually made by artificial, the dyeing and packaging are made by artificial cooperation with dyeing and packaging equipment, and the reading film is made by artificial cooperation with reading film equipment. The whole experimental process needs more than five persons, the artificial cost is high, and due to the participation of many persons, the data docking is inconvenient, and the experimental data error binding problem may occur. UTILITY MODEL CONTENT

[0004] The main purpose of the utility model is to provide a tablet making, dyeing and sealing and reading film integrated machine, which aims to improve the automation degree of tablet making, dyeing and sealing and reading film, improve the inspection efficiency, reduce the labor cost, and improve the data binding accuracy.

[0005] In order to achieve the above purpose, the utility model provides a tablet making, dyeing and sealing and reading film integrated machine, which comprises:

[0006] A rack;

[0007] A tablet making system, which comprises a pretreatment module and a tablet making module arranged on the rack, the pretreatment module is provided with an oscillation cavity for oscillating and mixing the sample, the tablet making module is provided with a pipettor and a centrifugal groove, the pipettor is used for transferring the sample into a tablet making clamp, and the centrifugal groove is used for centrifuging the sample in the tablet making clamp;

[0008] A dyeing and sealing system, which is arranged on the rack and is used for dyeing and packaging the sample;

[0009] A reading film system, which is arranged on the rack and is used for reading the packaged sample; and

[0010] A transfer system, the transfer system comprising a first transfer device and a second transfer device provided on the rack, the first transfer device is provided between the sample preparation system and the sample sealing system, and is used for transferring the centrifuged sample to the sample sealing system, the second transfer device is provided between the sample sealing system and the sample reading system, and is used for transferring the sealed sample to the sample reading system.

[0011] In an embodiment, the rack is provided with a sample tube loading position for placing a sample tube, and the pretreatment module comprises:

[0012] A first loading device provided on the rack and provided with a first clamping groove for clamping a sample tube;

[0013] A first turntable device provided on the rack and adjacent to the first loading device, the first turntable device is provided with a placing cavity for placing a sample tube;

[0014] An oscillation device provided on the rack, the oscillation device is provided with the oscillation cavity; and

[0015] An uncapping device provided on the rack, the uncapping device is provided with an uncapping cavity for uncapping a sample tube, and the oscillation device and the uncapping device are provided on different sides of the first turntable device;

[0016] The first loading device is used for transferring the sample tube on the loading position to the placing cavity, the first turntable device is used for transferring the sample tube in the placing cavity to the oscillation cavity, the oscillation device is used for oscillating the sample tube in the oscillation cavity, the first turntable device is further used for transferring the sample tube in the oscillation cavity to the uncapping cavity, and the uncapping device is used for uncapping the sample tube in the uncapping cavity.

[0017] In an embodiment, the first loading device comprises a first three-axis assembly, a first clamping assembly and a first code scanning assembly, the first three-axis assembly is connected to the rack, the first clamping assembly is connected to the output end of the first three-axis assembly and provided with the first clamping groove, and the first code scanning assembly is connected to the output end of the first three-axis assembly corresponding to the first clamping groove, and is used for scanning the code of the sample tube in the first clamping groove.

[0018] In an embodiment, the oscillation device comprises a fixed rod and an oscillation assembly provided on the rack, the output ends of the fixed rod and the oscillation assembly are spaced apart and surround to form the oscillation cavity, and the oscillation assembly is used for driving the sample tube in the oscillation cavity to oscillate.

[0019] In an embodiment, the cover opening device comprises a first rotating member, a first clamping member and a second clamping member, the first rotating member and the second clamping member are connected to the frame, the first clamping member is connected to the output end of the first rotating member, and the first clamping member and the second clamping member are arranged in a spaced manner to form the cover opening cavity.

[0020] In an embodiment, the frame is provided with a mold clip loading position for placing a mold clip, and the mold module comprises:

[0021] a second loading device provided on the frame and provided with a second clamping groove for clamping a mold clip;

[0022] a second rotating table device provided on the frame and adjacent to the second loading device, the second rotating table device is provided with a placing groove for placing a mold clip;

[0023] a pipetting device provided on the frame and provided with a pipette; and

[0024] a centrifugal mechanism comprising a centrifugal loading module and a centrifuge provided on the frame, the centrifugal loading module is provided with a third clamping groove for clamping a mold clip, and the centrifuge is provided with the centrifugal groove;

[0025] The second loading device is used to transfer the sample tube in the loading position to the placing groove, the second rotating table device is used to transfer the sample tube in the placing cavity to the pipetting device, the pipetting device is used to transfer the sample in the sample tube to the mold clip, the centrifugal loading module is used to transfer the mold clip with the sample to the centrifugal groove, and the centrifuge is used to centrifuge the sample in the centrifugal groove.

[0026] In an embodiment, the frame is provided with a tip placing position for placing a tip, and the pipetting device comprises a pipetting three-axis assembly and a pipette, the pipetting three-axis assembly is connected to the frame, and the pipette is connected to the output end of the pipetting three-axis assembly.

[0027] In an embodiment, the centrifugal loading module comprises a centrifugal three-axis assembly and a centrifugal clamping assembly, the centrifugal three-axis assembly is connected to the frame, the centrifugal clamping assembly is provided at the output end of the centrifugal three-axis assembly and provided with a centrifugal clamping groove, and the centrifugal clamping groove is used to clamp a mold clip.

[0028] And / or, the tabletting module further comprises a marking device and a second code scanning assembly, the marking device and the second code scanning assembly are located at different sides of the second rotary table device respectively, the marking device is provided with a marking head for marking the tabletting clamp, and the second code scanning assembly is used for scanning the code of the marked tabletting clamp.

[0029] In an embodiment, the tabletting module further comprises a conveying device, a third code scanning assembly and a pressing assembly provided on the rack, the conveying device is provided with a conveying belt, and the third code scanning assembly and the pressing assembly are sequentially arranged along the conveying belt; the conveying device is provided with a conveying belt for conveying the tabletting clamp after centrifugation.

[0030] The centrifugal loading module is used for placing the tabletting clamp after centrifugation on the conveying belt, the conveying device is used for driving the tabletting clamp to sequentially pass through the third code scanning assembly and the pressing assembly, the third code scanning assembly is used for scanning the code of the tabletting clamp, and the pressing assembly is used for fixing the tabletting clamp to pull out the settling tank of the tabletting clamp by the first transfer device and take out the slide.

[0031] In an embodiment, the first transfer device comprises a mechanical arm and a transfer clamp, the mechanical arm is connected to the rack, and the transfer clamp is connected to the output end of the transfer clamp; the transfer clamp is used for clamping the slide.

[0032] The technical scheme of the utility model discloses a slide preparation, dyeing and sealing and film reading integrated machine, which comprises a rack, a slide preparation system, a dyeing and sealing system, a film reading system and a transfer system, the slide preparation system comprises a pretreatment module and a tabletting module arranged on the rack, the pretreatment module is used for pretreating the collected sample, and the tabletting module is used for preparing the sample after pretreatment; the dyeing and sealing system is arranged on the rack, and is used for dyeing and sealing the sample; the film reading system is arranged on the rack, and is used for reading the sealed sample; the transfer system comprises a first transfer device and a second transfer device arranged on the rack, the first transfer device is arranged between the slide preparation system and the dyeing and sealing system, and is used for transferring the prepared sample to the dyeing and sealing system, and the second transfer device is arranged between the dyeing and sealing system and the film reading system, and is used for transferring the sealed sample to the film reading system. In the whole sample preparation process, in addition to manually supplementing the sample and consumed materials, the linkage control of various systems is realized, and the free switching of the sample between various systems is realized by the transfer system, so that the liquid-based cell slide preparation, dyeing, sealing and film reading are fully automated. BRIEF DESCRIPTION OF DRAWINGS

[0033] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained according to the structures shown in these drawings without creative labor.

[0034] Figure 1 The structure schematic diagram of the film making, dyeing and sealing and film reading integrated machine in one embodiment of the present application is provided.

[0035] Figure 2 For Figure 1 The local enlarged view of A in the middle;

[0036] Figure 3 The structure schematic diagram of the film making system in one embodiment of the present application is provided.

[0037] Figure 4 The structure schematic diagram of the dyeing and sealing system and the film reading system in one embodiment of the present application is provided.

[0038] Figure 5 The structure schematic diagram of the first rotary table device, the oscillation device and the cover opening device in one embodiment of the present application is provided.

[0039] Figure 6 The structure schematic diagram of the second rotary table device, the marking device and the second code scanning assembly in one embodiment of the present application is provided.

[0040] Figure 7 The structure schematic diagram of the pipetting device in one embodiment of the present application is provided.

[0041] Figure 8 The structure schematic diagram of the centrifuge in one embodiment of the present application is provided.

[0042] Figure 9 The structure schematic diagram of the conveying device, the third code scanning assembly and the pressing assembly in one embodiment of the present application is provided.

[0043] Figure 10 The structure schematic diagram of the first transfer device in one embodiment of the present application is provided.

[0044] Explanation of the drawing reference numerals:

[0045] 100, a machine for film making, dyeing and sealing and film reading; 1, a machine frame; 11, a sample tube loading position; 12, a film making clamp loading position; 13, a gun head placement position; 14, an alcohol box; 2, a film making system; 21, a first loading device; 211, a first three-axis assembly; 212, a first clamping assembly; 22, a first rotary table device; 221, a placement cavity; 23, a vibration device; 231, a fixed rod; 232, a vibration assembly; 233, a vibration cavity; 24, a cover opening device; 241, a first rotating piece; 242, a first clamping piece; 243, a second clamping piece; 244, a cover opening cavity; 25, a second loading device; 26, a second rotary table device; 261, a placement groove; 27, a pipetting device; 271, a pipetting three-axis assembly; 272, a pipette; 28, a centrifugal mechanism; 281, a centrifugal loading module; 2811, a centrifugal three-axis assembly; 2812, a centrifugal clamping assembly; 282, a centrifuge; 29, a conveying device; 291, a third code scanning assembly; 292, a pressing assembly; 3, a marking device; 4, a second code scanning assembly; 5, a first transfer device; 51, a mechanical arm; 52, a transfer clamping piece; 6, a dyeing and sealing system; 61, a dyeing and sealing device; 611, a dyeing cavity; 62, a drying device; 621, an oven; 622, a moving three-axis device; 63, a dyeing and sealing code scanning assembly; 7, a film reading system; 71, a double-station film reading machine; 72, a bright film disc; 8, a second transfer device.

[0046] The implementation, functional features and advantages of the utility model will be further described with reference to the drawings in combination with embodiments. DETAILED DESCRIPTION

[0047] The technical solutions in the embodiments of the utility model will be clearly and completely described below in combination with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor belong to the protection scope of the utility model.

[0048] It should be noted that if the embodiments of the utility model involve directional indications (such as up, down, left, right, front, back, etc.), the directional indications are only used to explain the relative position relationship, movement condition, etc. between the components in a certain posture, and if the certain posture changes, the directional indications also change accordingly.

[0049] In addition, if the description of "first", "second" and the like is involved in the embodiments of the utility model, the description of "first", "second" and the like is only for the purpose of description, and cannot be understood as indicating or implying the relative importance of the same or implicitly indicating the number of the indicated technical features. Therefore, the features limited by "first", "second" can be explicitly or implicitly included at least one of the features. In addition, if "and / or" or "and / or" appears throughout the text, its meaning includes three parallel schemes. For example, "A and / or B" includes A scheme, or B scheme, or A and B simultaneously satisfy the scheme. In addition, the technical solutions of each embodiment can be combined with each other, but it must be based on the realization of ordinary skilled in the art, when the combination of technical solutions appears contradictory or cannot be realized, it should be considered that the combination of technical solutions does not exist, also not within the protection scope required by the utility model.

[0050] As shown in Figures 1 to 10 The utility model proposes a kind of making, dyeing and reading integrated machine 100, making, dyeing and reading integrated machine 100 include rack 1, making system 2, dyeing and sealing system 6, reading system 7 and transfer system, making system 2 includes the pretreatment module and making module being located at rack 1, pretreatment module is equipped with oscillation cavity 233, for to sample oscillation mix, making module is equipped with pipettor 272 and centrifugal groove, pipettor 272 is used to be transferred to sample in making clamp, centrifugal groove is used to carry out centrifugation to the sample in making clamp;Dyeing and sealing system 6 is located at rack 1, dyeing and sealing system 6 is used to be dyed and packaged to sample;Reading system 7 is located at rack 1, reading system 7 is used to be read to the sample after packaging;Transfer system includes the first transfer device 5 and second transfer device 8 being located at rack 1, first transfer device 5 is located between making system 2 and dyeing and sealing system 6, for after centrifugation sample is transferred to dyeing and sealing system 6, second transfer device 8 is located between dyeing and sealing system 6 and reading system 7, for after packaging sample is transferred to reading system 7.

[0051] In the embodiment, the sample tube carrying the sample is subjected to oscillation mixing treatment by the oscillation cavity 233 of the pretreatment module, then the sample is transferred to the slide holder by the pipettor 272, and then the sample in the slide holder is subjected to centrifugal treatment, then the first transfer device 5 takes out the slide carrying the sample and transfers it to the staining and sealing system 6 for staining and sealing treatment, and the second transfer device 8 transfers the sealed sample to the reading system 7 for reading observation. Thus, the entire slide preparation, staining and sealing and reading steps are completed, realizing the integration and automation of the slide preparation system 2, the staining and sealing system 6 and the reading system 7. In the entire sample preparation process, in addition to the manual replenishment of samples and consumables, the linkage control of the systems is realized, and the free transfer of samples between the systems is realized by the transfer system, so that the liquid-based cell slide preparation, staining, sealing and reading are fully automated, the labor cost is greatly saved, the detection efficiency is improved, and the data confusion in the entire sample preparation process is avoided, and the accurate correspondence of data is ensured.

[0052] In an embodiment of the utility model, the rack 1 is provided with a sample tube loading position 11, the sample tube loading position 11 is used to place a sample tube, the pretreatment module includes a first loading device 21, a first rotary table device 22, an oscillation device 23 and a cover opening device 24, the first loading device 21 is arranged on the rack 1 and is provided with a first clamping groove for clamping a sample tube, the first rotary table device 22 is arranged on the rack 1 and is arranged adjacent to the first loading device 21, the first rotary table device 22 is provided with a placing cavity 221 for placing a sample tube, the oscillation device 23 is arranged on the rack 1, and the oscillation device 23 is provided with an oscillation cavity 233, the cover opening device 24 is arranged on the rack 1, and the cover opening device 24 is provided with a cover opening cavity 244 for opening the cover of a sample tube, and the oscillation device 23 and the cover opening device 24 are arranged on different sides of the first rotary table device 22, wherein the first loading device 21 is used to transfer the sample tube of the loading position to the placing cavity 221, the first rotary table device 22 is used to transfer the sample tube of the placing cavity 221 to the oscillation cavity 233, the oscillation device 23 is used to oscillate the sample tube in the oscillation cavity 233, the first rotary table device 22 is further used to transfer the sample tube in the oscillation cavity 233 to the cover opening cavity 244, and the cover opening device 24 is used to open the cover of the sample tube in the cover opening cavity 244.

[0053] In the embodiment, the sample tube loading position 11 of the rack 1 is provided with a sample tube containing a sample, and the sample tube is placed in a sample tube placing rack to facilitate batch placing of the sample tube. Then the first loading device 21 clamps the sample tube at the sample tube loading position 11 through a first clamping groove and places the sample tube in a placing cavity 221 of the first rotary table device 22, the first rotary table device 22 transfers the sample tube to a shaking cavity 233 of the shaking device 23, the shaking device 23 shakes the sample tube in the shaking cavity 233, the first rotary table device 22 transfers the sample tube to the cap opening device 24, the cap opening device 24 opens the cap of the sample tube to facilitate subsequent sampling of the sample. When the sampling of the sample tube is completed, the cap opening device 24 closes the cap of the sample tube, and the first loading device 21 unloads the sample tube.

[0054] In an embodiment of the utility model, the first loading device 21 includes a first three-axis assembly 211, a first clamping assembly 212 and a first code scanning assembly, the first three-axis assembly 211 is connected to the rack 1, the first clamping assembly 212 is connected to the output end of the first three-axis assembly 211 and is provided with a first clamping groove, and the first code scanning assembly is connected to the output end of the first three-axis assembly 211 corresponding to the first clamping groove and is used for scanning the code of the sample tube in the first clamping groove.

[0055] In the embodiment, the first loading device 21 is composed of the first three-axis assembly 211, the first clamping assembly 212 and the first code scanning assembly, the first three-axis assembly 211 is combined by X-axis, Y-axis and Z-axis driving members, and the X-axis, Y-axis and Z-axis driving members can be a combination of electric cylinders or sliding rails, motors and screws, which are not limited here. The first clamping assembly 212 is connected to the output end of the first three-axis assembly 211, the first three-axis assembly 211 drives the first clamping assembly 212 to approach the sample tube loading position 11, the first clamping assembly 212 clamps and fixes the sample tube through the first clamping groove, and at the same time, the first code scanning assembly scans the code of the sample tube fixed in the first clamping groove to facilitate subsequent tracking of the sample. Then the first three-axis driving assembly drives the first clamping assembly 212 to carry the sample tube to the first rotary table device 22, the first clamping assembly 212 releases the sample tube to make the sample tube fall into the limiting cavity of the first rotary table device 22. The first clamping assembly 212 can be a pneumatic clamp jaw or an electric clamp jaw, and the first code scanning assembly is a bar code scanner or other types of code scanners, which are not limited here. Alternatively, the first clamping assembly 212 can include a rotating motor and a pneumatic clamp jaw, and when the pneumatic clamp jaw clamps the sample tube, the rotating motor drives the pneumatic clamp jaw to rotate the sample tube around the shaft to make the first scanning assembly scan the code along the circumference of the sample tube.

[0056] In actual implementation, the first rotating device 22 comprises a first rotating driving member and a first rotating frame, the first rotating driving member is connected to the frame 1, the first rotating frame is connected to the first rotating driving member, the first rotating frame is provided with a limiting cavity, the first feeding device 21, the oscillation device 23 and the cover opening device 24 are arranged on different sides of the rotating frame corresponding to the sample tube feeding position 11, the oscillation position and the cover opening position. It can be understood that the first rotating frame is provided with four first placing arms, adjacent two first placing arms are arranged at right angles, each first placing arm is provided with a limiting cavity, three placing arms correspond to the sample tube feeding position 11, the oscillation position and the cover opening position respectively, the first clamping assembly 212 feeds the limiting cavity located at the sample tube feeding position 11, then the first rotating driving member drives the first rotating frame to rotate 90°, so that the first placing arm located at the sample tube feeding position 11 is transferred to the oscillation position, at this time, the sample tube located in the placing cavity 221 is also located in the oscillation cavity 233, the oscillation device 23 oscillates the sample tube, then the first rotating driving member drives the first rotating frame to rotate 90°, so that the first placing arm of the oscillation position is transferred to the cover opening position, at this time, the sample tube located in the placing cavity 221 is also located in the cover opening cavity 244, the cover opening device 24 opens the cover, the sample in the sample tube is taken by the sample preparation module, after the liquid taking is completed, the cover opening device 24 closes the cover, finally, the first rotating driving member drives the first rotating frame to rotate 180°, so as to drive the sample tube to return to the sample tube feeding position 11, and the first feeding device 21 feeds the sample tube. The first rotating driving member can be a motor, the first placing arm comprises a placing plate for limiting the sample tube in the circumferential direction of the sample tube and a placing rod for supporting the sample tube, which is not limited here.

[0057] In an embodiment of the present application, the oscillation device 23 comprises a fixing rod 231 arranged on the frame 1 and an oscillation assembly 232, the output ends of the fixing rod 231 and the oscillation assembly 232 are arranged at intervals and surround to form an oscillation cavity 233, and the oscillation assembly 232 is used to drive the sample tube in the oscillation cavity 233 to oscillate.

[0058] In the embodiment, the oscillation device 23 is composed of the fixing rod 231 and the oscillation assembly 232, the fixing rod 231 and the oscillation assembly 232 are both connected to the frame 1, at least part of the fixing rod 231 extends above the sample tube, the oscillation assembly 232 is arranged below the sample tube, and the fixing rod 231 and the oscillation assembly 232 surround to form the oscillation cavity 233. The oscillation assembly 232 comprises a lifting motor and a top rod, the top rod is connected to the bottom of the lifting motor, when the sample tube in the limiting cavity reaches the oscillation cavity 233, the lifting motor drives the top rod to drive the sample tube to reciprocate to oscillate, and the fixing rod 231 above the sample tube is used to place the sample tube to be pushed out of the limiting cavity.

[0059] It can be understood that the first rotary table device 22 further comprises a through hole communicating with the limiting cavity from the bottom, so as to extend the top rod into the limiting cavity or extend the top rod out of the limiting cavity, which is not specifically limited here.

[0060] In an embodiment of the utility model, the cover opening device 24 comprises a first rotating member 241, a first clamping member 242 and a second clamping member 243, the first rotating member 241 and the second clamping member 243 are connected to the rack 1, the first clamping member 242 is connected to the output end of the first rotating member 241, the first clamping member 242 and the second clamping member 243 are arranged at intervals and enclose to form a cover opening cavity 244.

[0061] In the embodiment, the cover opening device 24 is composed of the first rotating member 241, the first clamping member 242 and the second clamping member 243, the cover opening cavity 244 is formed between the first clamping member 242 and the second clamping member 243, when the first rotary table device 22 transfers the sample tube to the cover opening position, the first clamping member 242 is located above the sample tube, the second clamping member 243 is located below the sample tube, the first clamping member 242 clamps and fixes the cover of the sample tube, the second clamping member 243 clamps and fixes the tube body of the sample tube, then the first rotating member 241 rotates the first clamping member 242 to rotate, so as to unscrew the cover from the tube body, so as to facilitate subsequent pipetting operation on the sample, after the pipetting is completed, the cover opening device 24 also covers the cover on the tube body, and the specific process can be referred to the cover opening process. In actual implementation, the cover opening device 24 further comprises a Y-axis driving member and a Z-axis driving member, the Y-axis driving member is connected to the rack 1, the Z-axis driving member is connected to the output end of the Y-axis driving member, the first rotating member 241 is connected to the output end of the Z-axis driving member, the Y-axis driving member is used to drive the Z-axis driving member, the first rotating member 241 and the first clamping member 242 to move away from above the sample tube during pipetting, so as to avoid interfering with pipetting. The Z-axis driving member is used to drive the first rotating member 241 to ascend or descend, so as to take off the cover from the tube body or put back the cover on the tube body. The Y-axis driving member and the Z-axis driving member are a combination of an electric cylinder or a slide rail, a motor and a screw rod, the first rotating member 241 is a rotating motor, and the first clamping member 242 and the second clamping member 243 are pneumatic clamping jaws or electric clamping jaws, which are not specifically limited here.

[0062] In an embodiment of the utility model, the rack 1 is equipped with a film -wound clamp loading position 12, the film -wound clamp loading position 12 is used for placing film -wound clamp, and the film -wound module includes second loading device 25, second rotary table device 26, pipette device 27 and centrifuge structure 282 28, second loading device 25 is located in the rack 1, and is equipped with second clamping groove, is used for clamping film -wound clamp, second rotary table device 26 is located in the rack 1, and is adjacent with second loading device 25, and second rotary table device 26 is equipped with placing groove 261, is used for placing film -wound clamp, and pipette device 27 is located in the rack 1, and is equipped with pipette 272, and centrifugal structure includes centrifugal loading module 281 and centrifuge 282 located in the rack 1, and centrifugal loading module 281 is equipped with third clamping groove, is used for clamping film -wound clamp, and centrifuge 282 is equipped with centrifugal groove, wherein, second loading device 25 is used for transferring the sample tube of loading position to placing groove 261, second rotary table device 26 is used for transferring the sample tube of placing cavity 221 to pipette device 27, pipette device 27 is used for transferring the sample in sample tube to film -wound clamp, centrifugal loading module 281 is used for transferring the film -wound clamp with sample to centrifugal groove, and centrifuge 282 is used for centrifuging the sample in centrifugal groove.

[0063] In the embodiment, the film -wound clamp loading position 12 of the rack 1 is placed with empty film -wound clamp, and the film -wound clamp includes base, settling bin and slide between the two, and the film -wound clamp is placed in film -wound clamp placing rack, so as to facilitate the batch placement of film -wound clamp.Second loading device 25 clamps the film -wound clamp at film -wound clamp loading position 12 through second clamping groove, and places the film -wound clamp in placing groove 261 of first rotary table device 22, and first rotary table device 22 transfers the film -wound clamp to pipette device 27, and pipette device 27 takes sample in uncapped sample tube through pipette 272, and injects the sample into settling bin, and second rotary table device 26 transfers pipette device 27 to centrifugal loading module 281 of centrifuge 282 structure 28, and centrifugal loading module 281 clamps the film -wound clamp after pipetting through third clamping groove, and places it in centrifugal groove of centrifuge 282 to carry out centrifugal treatment.

[0064] In an embodiment of the utility model, the rack 1 is equipped with gun head placing position 13, and the gun head placing position 13 is used for placing gun head, and pipette device 27 includes pipette three-axis assembly 271 and pipette 272, and pipette three-axis assembly 271 is connected to the rack 1, and pipette 272 is connected to the output end of pipette three-axis assembly 271.

[0065] In the embodiment, the tip placing position 13 of the rack 1 is placed with a tip, and the tip is placed in a tip placing rack to facilitate batch placing of the tip. Before pipetting, the pipetting three-axis assembly 271 drives the pipette 272 to approach the tip placing position 13, and a clean tip is transferred to the pipette 272. Then the pipetting three-axis drive member drives the pipette 272 to extend the tip into a sample tube and perform pipetting. Then the pipetting three-axis drive member drives the pipette 272 to extend the tip into a settling bin and perform dispensing, thereby completing the pipetting process. It can be understood that the pipetting three-axis assembly 271 includes X-axis, Y-axis and Z-axis drive members, which can be a combination of electric cylinders or sliding rails, motors and screws, and are not limited here. In actual implementation, the rack 1 is also provided with a pipetting head waste bin. When the pipetting is completed once, the pipetting three-axis drive member drives the pipette 272 to reach the bin opening of the pipetting head waste bin, and the pipette 272 releases the tip to collect the used tip. Each time pipetting is performed, the pipette 272 is transferred with a new tip to avoid mutual contamination between samples.

[0066] In an embodiment of the utility model, centrifugal feeding module 281 includes centrifugal three-axis assembly 2811 and centrifugal clamping assembly 2812, centrifugal three-axis assembly 2811 is connected to rack 1, centrifugal clamping assembly 2812 is located at the output end of centrifugal three-axis assembly 2811, and is provided with centrifugal clamping groove, and the centrifugal clamping groove is used for clamping the slice making clamp, and / or, the slice making module further includes marking device 3 and second code scanning assembly 4, marking device 3 and second code scanning assembly 4 are located at different sides of second rotary table device 26 respectively, marking device 3 is provided with marking head and is used for marking the slice making clamp, and second code scanning assembly 4 is used for scanning the code of the marked slice making clamp.

[0067] In the embodiment, centrifugal feeding module 281 includes centrifugal three-axis assembly 2811 and centrifugal clamping assembly 2812. Before centrifugation, centrifugal three-axis assembly 2811 drives centrifugal clamping assembly 2812 to approach the slice making clamp after pipetting is completed. Centrifugal clamping assembly 2812 clamps the slice making clamp through the centrifugal clamping groove. Then centrifugal three-axis assembly 2811 drives centrifugal clamping assembly 2812 to approach the centrifugal groove of the centrifuge 282. Centrifugal clamping assembly 2812 releases the slice making clamp to place it in the centrifugal groove, and the centrifuge 282 performs centrifugation. The centrifugal three-axis assembly 2811 is composed of X-axis, Y-axis and Z-axis drive members, which can be a combination of electric cylinders or sliding rails, motors and screws. The centrifugal clamping assembly 2812 can be a pneumatic clamping jaw or an electric clamping jaw, and is not limited here.

[0068] In actual implementation, the second rotary table device 26 comprises a second rotary driving member and a second rotary frame, the second rotary driving member is connected to the rack 1, the second rotary frame is connected to the second rotary driving member, the second rotary frame is provided with a limiting slot, the second feeding device 25, the pipetting device 27 and the centrifuge 282 are respectively arranged on different sides of the rotary frame corresponding to the sample holder loading position 12, the pipetting position and the centrifuging position. It can be understood that the second rotary frame is provided with four second placing arms, adjacent two second placing arms are arranged at right angles, each second placing arm is provided with a limiting slot, and the four placing arms correspond to the sample holder loading position 12, the marking position, the pipetting position and the centrifuging position respectively. In the embodiment, the marking device 3 is arranged on one side of the second rotary table device 26 corresponding to the sample holder loading position 12, when the second feeding device 25 completes feeding on the limiting slot of the sample tube loading position 11, the second rotary driving member drives the second rotary frame to rotate, so that the second placing arm located at the glass holder loading position is transferred to the marking position, and the marking device 3 marks the same, after marking, the second rotary driving member drives the second rotary frame to rotate, so that the second placing arm located at the glass holder loading position is transferred to the pipetting position, at this time, the pipetting device 27 moves the sample into the settling chamber of the glass holder, then the second rotary driving member drives the second rotary frame to rotate again, so that the second placing arm is transferred to the centrifuging position, the centrifugal feeding module 281 transfers the sample holder to the centrifuge 282, and the centrifuge 282 centrifugates the same. The second rotary driving member can be a motor, and the marking device 3 is a laser marker, which is not limited here.

[0069] In the embodiment, the second code scanning assembly 4 is arranged on the other side of the second rotary table device 26 corresponding to the pipetting position, and the sample holder is scanned before the pipetting device 27 performs pipetting, so that the data of the sample holder and the corresponding sample tube are bound, and the second code scanning assembly 4 can be a bar code scanner. In actual implementation, the rack 1 is further provided with a syringe corresponding to the marking position, when the second rotary table device 26 moves the sample holder to the marking position, the outlet of the syringe faces the settling chamber, and the syringe is used for injecting cleaning liquid into the settling chamber, so as to dilute the sample, which is beneficial to the separation of impurities and cells during centrifugation.

[0070] In an embodiment of the utility model, the sample holder module further comprises a conveying device 29, a third code scanning assembly 291 and a pressing assembly 292 arranged on the rack 1, the conveying device 29 is provided with a conveying belt, the third code scanning assembly 291 and the pressing assembly 292 are sequentially arranged along the conveying belt, the conveying device 29 is provided with a conveying belt, and the conveying belt is used for conveying the sample holder after centrifugation;The centrifugal feeding module 281 is used for placing the sample holder after centrifugation on the conveying belt, the conveying device 29 is used for driving the sample holder to sequentially pass through the third code scanning assembly 291 and the pressing assembly 292, the third code scanning assembly 291 is used for scanning the sample holder, and the pressing assembly 292 is used for fixing the sample holder, so that the first transfer device 5 pulls out the settling chamber of the sample holder and takes out the slide.

[0071] In the embodiment, the conveying device 29 is sequentially provided with a placing station, a code scanning station and a splitting station along the conveying direction. After the centrifuge 282 completes centrifugation on the sample, the centrifugal feeding device drives the sample plate holder in the centrifugal groove and places it on the placing station of the conveying belt. Then the conveying device 29 drives the conveying belt to move, so that the sample plate holder reaches the code scanning station. The third code scanning assembly 291 scans the sample plate holder to confirm the information of the sample plate holder. After the scanning is completed, the conveying device 29 drives the conveying belt to drive the sample plate holder to the splitting station. The lower pressing assembly 292 presses the base of the sample plate holder. The first transfer device 5 twists off the upper part of the sample plate holder and transfers the slide in the sample plate holder to the slide rack in the alcohol box 14 for fixing. After a period of time, the first transfer device 5 transfers the slide to the dyeing and sealing system 6 for dyeing and sealing treatment. It can be understood that the rack 1 is provided with the alcohol box 14, and the alcohol box 14 is provided with the slide rack.

[0072] In actual implementation, the rack 1 is provided with a sedimentation bin waste bin and a base waste bin. After the first transfer device 5 twists off the upper part of the sample plate holder, the first transfer device 5 throws it into the sedimentation bin waste bin. The base waste bin is located at the end of the conveying belt. After the first transfer device 5 removes the slide, the conveying device 29 drives the conveying belt to continue to move, so that the base of the sample plate holder is sent into the base waste bin. The third code scanning assembly 291 can be a bar code scanner. The lower pressing assembly 292 includes a lower pressing driving element and a lower pressing block. The lower pressing driving element is connected to the rack 1. The lower pressing block is connected to the output end of the lower pressing driving element. The lower pressing driving element drives the lower pressing block to press down or lift up, so as to press or release the base of the sample plate holder. The lower pressing driving element can be an electric cylinder or a combination of a slide rail, a motor and a screw rod, which is not limited here.

[0073] In another embodiment of the utility model, the conveying device 29 includes a linear driving element, a lifting driving element, a fixed frame and a moving frame. The linear driving element is connected to the rack 1. The lifting driving element is connected to the output end of the linear driving element. The moving frame is connected to the output end of the lifting driving element. The moving frame is provided with a placing groove for placing the sample plate holder and is arranged between the fixed frames. The fixed frame is provided with a limiting groove corresponding to each station. When the conveying device 29 moves the sample plate holder to a certain station, the two ends of the sample plate holder are limited in the limiting groove. When the conveying device 29 moves the sample plate holder, the lifting driving element drives the moving frame to lift the sample plate holder, so as to extract the sample plate holder from the limiting groove. Then the linear driving element drives the lifting driving element to move the moving frame to the next station. After moving to the position, the lifting driving element drives the moving frame to lower the sample plate holder, so that the two ends of the sample plate holder are limited in the limiting groove. In this way, the conveying device 29 completes the transfer of the sample plate holder.

[0074] In an embodiment of the utility model, first transfer device 5 includes mechanical arm 51 and transfer clamp 52, mechanical arm 51 is connected to rack 1, transfer clamp 52 is connected to the output end of mechanical arm 51, and transfer clamp 52 is used to clamp the slide.

[0075] In the embodiment, first transfer device 5 is composed of mechanical arm 51 and transfer clamp 52, mechanical arm 51 is four, six, eight or ten axes or the like, and the number of movable axes of mechanical arm 51 can be set according to actual conditions, which is not specifically limited here. Transfer clamp 52 is arranged at the output end of mechanical arm 51, and mechanical arm 51 drives transfer clamp 52 to move between film production system 2 and dyeing and sealing system 6. Transfer clamp 52 can be a pneumatic clamp jaw or an electric clamp jaw, which is not specifically limited here. Transfer clamp 52 can be used to clamp the upper part of the film production clamp, and mechanical arm 51 can drive transfer clamp 52 to unscrew the upper part of the film production clamp and drop it into the sedimentation waste bin. Transfer clamp 52 can also be used to clamp the slide and transfer the slide. In actual implementation, the structure and working principle of second transfer device 8 are similar to those of first transfer device 5, which is used to move the slide between the dyeing and sealing system and the film reading system 7, and will not be described in detail here.

[0076] In actual implementation, the dyeing and sealing system 6 in the present scheme includes a dyeing and sealing device 61 and a drying device 62. The dyeing and sealing device 61 includes a dyeing assembly, a sealing assembly and a transfer assembly, and is provided with a dyeing cavity 611. The first transfer device 5 puts the slide rack in the alcohol box 14 together with the slide into the dyeing cavity 611. The dyeing and sealing device 61 performs dyeing according to the preset program. After dyeing is completed, the transfer assembly takes out the slide rack from the dyeing cavity 611, flips it and sends it to the sealing assembly for sealing. The dyeing and sealing device 61 and the drying device 62 can adopt a mature dyeing and sealing integrated machine on the market. Understandably, the marking device 3 in the film production module can simultaneously mark the film production clamp and the slide in the film production clamp. The dyeing and sealing device 61 can be provided with a dyeing and sealing code scanning assembly 63. The sealed slide is scanned to facilitate the traceability of sample information. The drying device 62 includes a movable three-axis device 622 arranged on the rack 1 and an oven 621. The oven 621 is provided with an entrance and exit for the slide to enter and exit. The output end of the movable three-axis device 622 is provided with a pneumatic clamp jaw for clamping the slide. The sealed slide is moved into the oven 621 for drying by the movable three-axis device 622, or the slide can be moved out of the oven 621. The oven 621 is internally provided with a turntable driven to rotate by a servo motor. The turntable is provided with a placing plate for placing the slide. The oven 621 is internally provided with a temperature sensor for monitoring the internal temperature. The oven 621 is also provided with an exhaust port connected to an exhaust fan to exhaust harmful gases.

[0077] The film reading system 7 comprises a double-station film reader 71 and a bright film tray 72, the film reader can adopt a mature film reader on the market, the second transfer device 8 is used to transfer the dried glass slide from the mobile three-axis device 622 to the film reading station of the film reader, then the film reader carries out film reading and uploads data, and then the second transfer device 8 places the glass slide after film reading on the bright film tray 72 on the rack 1, so as to facilitate the collection of the glass slide. In actual implementation, a film reading code scanning assembly can also be arranged in the film reading system 7, and the second transfer device 8 can pass the film reading code scanning assembly to scan the code before moving the glass slide to the film reading station, so as to facilitate the tracking of the film reading data of the sample.

[0078] The above merely illustrates the embodiments of the present application, and does not limit the patent scope of the present application, and any equivalent structural transformation, direct / indirect application in other related technical fields within the technical concept of the present application, and the contents of the present application specification and drawings are included in the patent protection scope of the present application.

Claims

1. A machine for film processing, dyeing, sealing and reading, characterized in that it comprises: The film making, dyeing and sealing and film reading integrated machine comprises: a rack; a film making system comprising a pretreatment module and a film making module arranged on the rack, the pretreatment module being provided with an oscillation cavity for oscillating and mixing the sample, the film making module being provided with a pipettor for transferring the sample into a film making clamp and a centrifugal groove for centrifuging the sample in the film making clamp; a dyeing and sealing system arranged on the rack, the dyeing and sealing system being used for dyeing and sealing the sample; a film reading system arranged on the rack, the film reading system being used for reading the sealed sample; and a transfer system comprising a first transfer device and a second transfer device arranged on the rack, the first transfer device being arranged between the film making system and the dyeing and sealing system and being used for transferring the centrifuged sample to the dyeing and sealing system, the second transfer device being arranged between the dyeing and sealing system and the film reading system and being used for transferring the sealed sample to the film reading system.

2. The film processing, staining, and reading integrated machine of claim 1, wherein the film processing, staining, and reading integrated machine further comprises a film processing unit, a film staining unit, and a film reading unit. The rack is provided with a sample tube loading position for placing the sample tube, and the pretreatment module comprises: a first loading device arranged on the rack and provided with a first clamping groove for clamping the sample tube; a first rotary table device arranged on the rack and adjacent to the first loading device, the first rotary table device being provided with a placing cavity for placing the sample tube; an oscillation device arranged on the rack, the oscillation device being provided with the oscillation cavity; and an uncapping device arranged on the rack, the uncapping device being provided with an uncapping cavity for uncapping the sample tube, the oscillation device and the uncapping device being arranged on different sides of the first rotary table device; wherein the first loading device is used for transferring the sample tube at the loading position to the placing cavity, the first rotary table device is used for transferring the sample tube at the placing cavity to the oscillation cavity, the oscillation device is used for oscillating the sample tube in the oscillation cavity, and the first rotary table device is further used for transferring the sample tube in the oscillation cavity to the uncapping cavity, and the uncapping device is used for uncapping the sample tube in the uncapping cavity.

3. The film processing, staining, mounting and reading system of claim 2, wherein the film processing, staining, mounting and reading system further comprises a film reader. The first loading device comprises a first three-axis assembly, a first clamping assembly and a first code scanning assembly, the first three-axis assembly is connected to the rack, the first clamping assembly is connected to the output end of the first three-axis assembly and is provided with the first clamping groove, and the first code scanning assembly is connected to the output end of the first three-axis assembly corresponding to the first clamping groove and is used for scanning the code of the sample tube in the first clamping groove.

4. The film processing, staining, mounting and reading system of claim 2, wherein the film processing, staining, mounting and reading system further comprises a film reader. The oscillation device comprises a fixing rod and an oscillation assembly arranged on the rack, the output ends of the fixing rod and the oscillation assembly are arranged at intervals and surround to form the oscillation cavity, and the oscillation assembly is used for driving the sample tube in the oscillation cavity to oscillate.

5. The film processing, staining, mounting and reading system of claim 2, wherein the film processing, staining, mounting and reading system further comprises a film reader. The cover opening device comprises a first rotating member, a first clamping member and a second clamping member, the first rotating member and the second clamping member are connected to the rack, the first clamping member is connected to the output end of the first rotating member, and the first clamping member and the second clamping member are arranged in a spaced manner to form the cover opening cavity.

6. The integrated film preparation, staining, and reading machine as described in any one of claims 1 to 5, characterized in that, The rack is provided with a film clip loading position for placing a film clip, and the film clip module comprises: a second loading device provided on the rack and provided with a second clamping groove for clamping a film clip; a second rotary table device provided on the rack and adjacent to the second loading device, the second rotary table device is provided with a placing groove for placing a film clip; a pipetting device provided on the rack and provided with a pipette; and a centrifugal mechanism comprising a centrifugal loading module and a centrifuge provided on the rack, the centrifugal loading module is provided with a third clamping groove for clamping a film clip, and the centrifuge is provided with the centrifugal groove; wherein the second loading device is used to transfer the sample tube in the loading position to the placing groove, the second rotary table device is used to transfer the sample tube in the placing cavity to the pipetting device, the pipetting device is used to transfer the sample in the sample tube to the film clip, the centrifugal loading module is used to transfer the film clip with the sample to the centrifugal groove, and the centrifuge is used to centrifuge the sample in the centrifugal groove.

7. The film processing, staining, mounting and reading system of claim 6, wherein the film processing, staining, mounting and reading system further comprises a film reader. The rack is provided with a gun head placing position for placing a gun head, and the pipetting device comprises a pipetting three-axis assembly and a pipette, the pipetting three-axis assembly is connected to the rack, and the pipette is connected to the output end of the pipetting three-axis assembly.

8. The film processing, staining, mounting and reading system of claim 6, wherein the film processing, staining, mounting and reading system further comprises a film reader. The centrifugal loading module comprises a centrifugal three-axis assembly and a centrifugal clamping assembly, the centrifugal three-axis assembly is connected to the rack, the centrifugal clamping assembly is provided on the output end of the centrifugal three-axis assembly and provided with a centrifugal clamping groove, and the centrifugal clamping groove is used to clamp a film clip. Moreover, the film clip module further comprises a marking device and a second code scanning assembly, the marking device and the second code scanning assembly are located on different sides of the second rotary table device respectively, the marking device is provided with a marking head for marking a film clip, and the second code scanning assembly is used to scan the code of the marked film clip.

9. The film processing, staining, mounting and reading system of claim 6, wherein the film processing, staining, mounting and reading system further comprises a film reader. The film clip module further comprises a conveying device, a third code scanning assembly and a pressing assembly provided on the rack, the conveying device is provided with a conveying belt, the third code scanning assembly and the pressing assembly are sequentially arranged along the conveying belt, the conveying device is provided with a conveying belt, and the conveying belt is used to convey the centrifuged film clip; wherein the centrifugal loading module is used to place the centrifuged film clip on the conveying belt, the conveying device is used to drive the film clip to sequentially pass through the third code scanning assembly and the pressing assembly, the third code scanning assembly is used to scan the code of the film clip, and the pressing assembly is used to fix the film clip to enable the first transfer device to pull out the sedimentation chamber of the film clip and take out the slide.

10. The film processing, staining, mounting and reading system of claim 9, wherein the film processing, staining, mounting and reading system further comprises a film reader. The first transfer device comprises a mechanical arm and a transfer gripper, the mechanical arm is connected to the rack, the transfer gripper is connected to the output end of the mechanical arm, and the transfer gripper is used for clamping a slide.

Images