Angle-adjustable and lockable hollow fiber bioreactor culture shelf

Abstract

The utility model discloses a hollow fiber bioreactor culture shelf, which comprises a culture plate, a hollow fiber bioreactor and a hollow fiber bioreactor, the supporting frame is provided with a rotating groove; the rotating column of the culture plate is arranged in the rotating groove of the supporting structure to realize the combination of the culture plate and the supporting structure and the adjustment of the angle of the culture plate, so that the culture plate can reach a horizontal state and an inclined state; the angle adjusting and locking structure is used for locking the position relation between the culture plate and the supporting structure when the culture plate reaches the horizontal state or the inclined state, and loosening and adjusting the relative position relation between the culture plate and the supporting structure when adjustment is needed, so that the culture plate is switched between the horizontal state and the inclined state. Through the arrangement of the culture shelf, the cell bioreactor can effectively complete initial planting in a horizontal state and complete growth culture in an inclined state, and finally the bioreactor cultured in the same batch has good homogeneity.

Description

TECHNICAL FIELD

[0001] The utility model belongs to stem cell culture instrument technical field especially, it is hollow fiber bioreactor's culture device, specifically it is a kind of hollow fiber bioreactor culture frame with adjustable and locked angle. BACKGROUND

[0002] CN112755288B A kind of extracorporeal liver support system is currently used temporarily by the patient of liver failure or waiting liver source one kind of system that liver plays the role, the system utilizes C3A hollow fiber bioreactor and plays the role of liver replacement.For providing sufficient qualified hollow fiber bioreactor for extracorporeal liver support, hollow fiber bioreactor needs to be cultured scientifically and effectively.

[0003] Wherein how to set hollow fiber bioreactor reasonably and effectively, guarantee the homogeneity of the hollow fiber bioreactor produced by unified batch, and further guarantee the stable treatment effect of hollow fiber bioreactor in subsequent treatment process, it is a real technical problem that needs to be solved.

[0004] The utility model provides a kind of hollow fiber bioreactor culture frame with adjustable and locked angle for the above technical problems. INVENTION CONTENTS

[0005] The hollow fiber bioreactor placing rack of prior art is a placing plate of inclined setting, multiple hollow fiber bioreactors are arranged on the placing plate, to ensure that the hollow fiber bioreactor for single extracorporeal liver support system comes from the hollow fiber bioreactor of same time culture, to ensure that the support efficiency of extracorporeal liver support system for treatment is same, to avoid different problems.

[0006] But in specific culture process, it is found that if maintaining a stationary inclination angle is used for the culture of hollow fiber bioreactor in whole process, cell between hollow fiber of hollow fiber bioreactor planted under the action of gravity will quickly move to the lower side of hollow fiber bioreactor under the action of gravity and flow of culture solution, and uneven distribution of planted cell appears, to further cause uneven distribution of cell of different hollow fiber bioreactor, and to cause uneven growth of cell reactor of same batch, which can affect treatment effect in subsequent use, but once initial cell planting is completed, inclination setting forms better liquid pressure due to the action of gravity, to promote that cell far from liquid input end can also be supplied with sufficient nutrition.

[0007] Therefore, for the initial cell planting stage of the hollow fiber bioreactor, it is best to place the hollow fiber bioreactor horizontally to ensure that the liquid pumped quickly drives the seeded cells to quickly spread throughout the hollow fiber bioreactor and adhere to the outer wall of the hollow fiber. Once evenly distributed, the hollow fiber bioreactor needs to be cultured in an inclined state to ensure that effective liquid pressure can be formed to promote cell propagation, so a culture rack with adjustable angle of the hollow fiber bioreactor is needed to provide support for the hollow fiber bioreactor.

[0008] The utility model provides a kind of hollow fiber bioreactor culture rack, it includes,

[0009] Culture plate is provided with rotating column;For setting multiple hollow fiber bioreactor;

[0010] Support frame is provided with rotating groove;The rotating column of culture plate is set to the rotating groove of support structure to realize the combination of culture plate and support structure and the adjustment of culture plate angle, so that culture plate can reach horizontal state and inclined state;

[0011] Angle adjustment and locking structure are used to lock the positional relationship of culture plate and support structure when culture plate reaches horizontal state or holds inclined state, and to loosen when adjustment is needed, adjust the relative positional relationship of culture plate and support structure, so that culture plate can switch between horizontal state and inclined state.

[0012] Further, culture plate includes top plate and peripheral plate, peripheral plate is arranged around top plate, peripheral plate includes first plate and second plate, and each first plate and second plate extends a rotating column, and rotating groove is provided on support frame to accommodate rotating column;Further, rotating groove includes upper guide groove with larger opening and lower adaptation groove matched with rotating column, which can conveniently set culture plate on support frame.

[0013] Further, support frame includes first support structure, second support structure, and further includes transverse support structure connecting first support structure and second support structure, which fixes support frame to incubator through transverse support structure, and one rotating groove is respectively arranged on first support structure and second support structure.

[0014] Further, the angle adjustment and locking structure is arranged on the first support structure and the corresponding first plate of the support frame or on the second support structure or the second plate, and the angle adjustment and locking structure can be a threaded rotating column and a locking nut sleeved on the rotating column. By rotating the locking nut along the rotating column, the first support structure and the corresponding first plate or the second support structure and the corresponding second plate are in close contact to achieve locking, and reverse rotation releases the close contact locking relationship to adjust the angle. Further, one horizontal blocking protrusion and one inclined blocking protrusion are arranged on the two sides of the inclined section respectively. When the adjusting plate touches the horizontal blocking protrusion, the culture plate reaches a horizontal state and is locked in the horizontal state by tightening the locking nut; when the adjusting plate touches the inclined blocking protrusion, the culture plate reaches an inclined state and is locked in the inclined state by tightening the locking nut. In this way, the horizontal and inclined maintenance states can be quickly and accurately given.

[0015] Alternatively, an extension plate is arranged on the first plate and / or the second plate, the extension plate is provided with two locking holes one for horizontal and inclined states, a locking hole two matched with the locking hole one is arranged on one of the first support structure and the second support structure, and a locking rod is further arranged. When one locking hole one and the locking hole two are matched, the locking rod is inserted into the hole to lock the angle of the culture plate.

[0016] Further, the distance from the two locking holes one to the axis of the rotating column is equal, and the locking hole two is arranged on the locking plate outside the rotating groove.

[0017] Further, the rotating column is arranged at the middle position of the culture plate, the culture plate is a face-symmetrical figure, and the central axis of the rotating column is on the longitudinal symmetry plane. Through this arrangement, the randomness of the culture plate setting can be ensured, and the up-down direction does not need to be specially distinguished.

[0018] Further, two groups of locking holes one are arranged on the first plate and the second plate with the longitudinal symmetry plane as the mirror plane. Through this arrangement, an effective horizontal state and an inclined state can be found in any way of placement.

[0019] Further, the first support structure and the second support structure each include a vertical section and an inclined section, and the inclined section is inclined upward. The vertical section is used to connect the horizontal support structure, and the rotating groove is arranged on the inclined section. By arranging the inclined section, effective rotating space can be provided for the culture plate. In addition, the inclined inclined section can introduce the entire culture plate into the space above, so that it can be effectively fixed on the side wall, can be introduced into the space above, and can increase the ease of operation.

[0020] Further, the setting part of the second locking hole downwardly inclined on the inclined section of one of the first support structure and the second support structure is inclined downwardly at the same angle as the angle of the inclined state of the culture plate, and the setting part can guarantee that the first locking hole and the second locking hole are in the state of being in alignment when the culture plate is in the state of being in alignment with the setting part of the second locking hole, and the locking rod is inserted in this way, and the state of being in alignment can be found very conveniently through the above setting.

[0021] Further, the diameter of the first locking hole is smaller than that of the second locking hole, a first locking section adapted to the first locking hole and a second locking section adapted to the second locking hole are arranged on the locking rod, and the step arrangement can guarantee that the position relationship after locking is more stable.

[0022] Further, the second end of the second locking section is provided with a holding operation section, and the holding operation section can guarantee the convenience of holding operation.

[0023] Further, a protection ring with a diameter larger than that of the holding operation section is arranged at each end of the holding operation section.

[0024] Technical effects

[0025] The hollow fiber bioreactor is arranged on the culture rack with an adjustable and locked angle, the state of the culture plate can be adjusted to control the hollow fiber bioreactor to be locked in the horizontal state and the inclined state, the state can be adjusted in the two states, and the horizontal state of the culture plate can meet the needs of planting culture and growth culture.

[0026] The angle adjusting and locking structure is arranged in the horizontal state and the inclined state, and the locking can be completed more quickly.

[0027] The culture plate is a face-symmetrical figure, the central axis of the rotating column is on the longitudinal symmetry plane, and two groups of first locking holes are arranged on the first plate and the second plate with the longitudinal symmetry plane as a mirror surface, so that an effective horizontal state and an inclined state can be found in any way without distinguishing the direction. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 An embodiment structure schematic view of the culture rack of the utility model arranged in a culture box is shown in the figure;

[0029] Figure 2 A partial structure schematic view of the culture rack of the utility model fixed to the culture box is shown in the figure;

[0030] Figure 3 A partial front side view structure schematic view of the culture rack of the utility model is shown in the figure;

[0031] Figure 4The utility model discares a culture frame part rear side view structure schematic diagram;

[0032] Figure 5 The utility model discares a culture frame part rear side view structure schematic diagram;

[0033] Figure 6 The utility model discares a culture frame part rear side view structure schematic diagram;

[0034] Figure 7 The utility model discares a culture frame part rear side view structure schematic diagram;

[0035] Figure 8 The utility model discares a culture frame part rear side view structure schematic diagram;

[0036] Figure 9 The utility model discares a culture frame part rear side view structure schematic diagram;

[0037] Main drawing mark explanation

[0038] 1, culture plate;11, top plate;121, first board;122, second board;13, rotating column;21, adaptation groove;22, guide groove;31, first support structure;32, second support structure;311, vertical section;312, inclined section;313, setting part;33, horizontal support structure;41, inclined blocking protrusion;42, horizontal blocking protrusion;43, extension plate;44, locking hole one;45, locking hole two;46, lock dead rod;461, locking section one;462, locking section two;463, protection ring;464, hold operating section;51, guide section;52, arc section;53, perpendicular section;54, horizontal plate;61, longitudinal rod;62, transverse rod;63, short perpendicular rod;7, incubator;8, culture tank;9, hollow fiber bioreactor. Specific implementation

[0039] Example 1

[0040] Reference Figures 1-9 A hollow fiber bioreactor 9 culture frame, it includes, culture plate 1 is provided with rotating column 13;Support frame is provided with rotating groove;Culture plate 1's rotating column 13 is set to the rotating groove of support structure, realizes the combination of culture plate 1 and support structure and the angle adjustment of culture plate 1, so that culture plate 1 can reach horizontal state and inclined state;

[0041] Angle adjustment and locking structure are used for when culture plate 1 reaches horizontal state or holds inclined state, lock culture plate 1 and the positional relationship of support structure, when needing adjustment, loosen, adjust the relative position relationship of culture plate 1 and support structure, so that culture plate 1 switches between horizontal state and inclined state.

[0042] More specifically, referring to Figures 3-4 The culture plate 1 comprises a top plate 11 and a surrounding plate arranged around the top plate 11, which can ensure that the culture plate 1 maintains a stable state without deformation, thereby ensuring the stability of the position relationship of the hollow fiber bioreactor 9 above it.

[0043] More specifically, the surrounding plate comprises a first plate 121 and a second plate 122, each of which extends a rotating column 13, and the support frame is provided with a rotating groove 22 corresponding to the rotating column 13; further, the rotating groove comprises an upper guide groove 22 with a larger opening and a lower adaptive groove 21 adapted to the rotating column 13, which can very conveniently set the culture plate 1 on the support frame. Finally, a combination mode is formed, which can be adjusted after the rotating column 13 is set in the rotating groove.

[0044] More preferably, referring to Figures 5-7 The support frame comprises a first support structure 31, a second support structure 32, and a transverse support structure 33 connecting the first support structure 31 and the second support structure 32, which is fixed to the incubator 7 through the transverse support structure 33. A rotating groove is arranged on each of the first support structure 31 and the second support structure 32.

[0045] More preferably, the angle adjusting and locking structure is arranged on the first support structure 31 and the corresponding first plate 121 of the support frame or on the second support structure 32 or the second plate 122. The angle adjusting and locking structure can be a threaded rotating column 13 and a locking nut sleeved on the rotating column 13, which is rotated along the rotating column 13 to make the first support structure 31 and the corresponding first plate 121 or the second support structure 32 and the corresponding second plate 122 tightly contact to realize locking, and the reverse rotation releases the tightly contact locking relationship to adjust the angle. (not shown in the figure) Further, referring to Figure 7 The two sides of the inclined section 312 are respectively provided with a horizontal blocking protrusion 42 and an inclined blocking protrusion 41, when the culture plate 1 is adjusted to touch the horizontal blocking protrusion 42, the culture plate 1 reaches the horizontal state, and is locked in the horizontal state by tightening the locking nut; when the culture plate 1 is adjusted to touch the inclined blocking protrusion 41, the culture plate 1 reaches the inclined state, and is locked in the inclined state by tightening the locking nut. In this way, the horizontal and inclined maintenance states can be quickly and accurately and effectively given.

[0046] Alternatively, referring to Figure 4 and Figure 9The angle adjusting and locking structure comprises: an extension plate 43 arranged on the first plate 121 and / or the second plate 122, two locking holes one 44 in horizontal state and inclined state arranged on the extension plate 43, a locking hole two 45 arranged on one of the first support structure 31 and the second support structure 32 and matched with the locking hole one 44, and a locking rod 46 arranged to be inserted into the hole when the locking hole one 44 and the locking hole two 45 are matched, so as to lock the angle of the culture plate 1.

[0047] More preferably, the culture plate 1 comprises a first plate 121 and a second plate 122, and the first plate 121 and the second plate 122 are arranged to be parallel to each other. Figure 9 More preferably, the distance between the two locking holes one 44 and the axis of the rotating column 13 is equal, and the locking hole two 45 is arranged on the locking plate outside the rotating groove.

[0048] More preferably, the rotating column 13 is arranged at the middle position of the culture plate 1, and the whole culture plate 1 is a face-symmetrical figure, and the central axis of the rotating column 13 is on the longitudinal symmetry plane.

[0049] More preferably, two groups of locking holes one 44 are arranged on the first plate 121 and the second plate 122 with the longitudinal symmetry plane as the mirror plane, so that an effective horizontal state and an inclined state can be found in any way of arrangement.

[0050] More preferably, the culture plate 1 comprises a first plate 121 and a second plate 122, and the first plate 121 and the second plate 122 are arranged to be parallel to each other. Figure 5 More preferably, the first support structure 31 and the second support structure 32 each comprise a vertical section 311 and an inclined section 312, and the inclined section 312 is inclined upward; the vertical section 311 is used to connect the transverse support structure 33, and the inclined section 312 is provided with a rotating groove; the inclined section 312 can provide effective rotating space for the culture plate 1, and the inclined section 312 can guide the whole culture plate 1 into the space above, so that the culture plate 1 can be effectively fixed on the side wall, can be guided into the space above, and the operation is convenient.

[0051] More preferably, the setting part 313 of the locking hole two 45 arranged downward on the inclined section 312 of one of the first support structure 31 and the second support structure 32, and the angle of the setting part 313 downward is the same as the angle of the culture plate 1 in the inclined state; when the culture plate 1 is parallel to the setting part 313 of the locking hole two 45, the locking hole one 44 in the inclined state and the locking hole two 45 are matched, and the locking rod 46 is inserted, so that the matched state can be found very conveniently.

[0052] More preferably, the culture plate 1 comprises a first plate 121 and a second plate 122, and the first plate 121 and the second plate 122 are arranged to be parallel to each other. Figure 8The diameter of the locking hole one 44 is smaller than that of the locking hole two 45, and a locking section one 461 adapted to the locking hole one 44 and a locking section two 462 adapted to the locking hole two 45 are arranged on the locking rod 46, so that the position relationship after locking is more stable.

[0053] In a more preferable embodiment, the first end of the locking section two 462 is connected to the locking section one 461, and a holding operation section 464 is arranged at the second end of the locking section two 462, so that the convenience of holding operation is ensured.

[0054] In a more preferable embodiment, a protection ring 463 with a larger diameter than the holding operation section 464 is arranged at both ends of the holding operation section 464, so that the hands are limited between the protection rings 463 during operation, and direct contact of the hands with the inclined section 312 during operation is avoided, thereby ensuring the safety of operation.

[0055] In a more specific embodiment, refer to Figures 1-3 The elastic clamps are arranged on the culture plate 1 to clamp the hollow fiber bioreactor 9, and each hollow fiber bioreactor 9 is provided with two elastic clamps, so that the stability of clamping is ensured. Each elastic clamp includes two arc sections 52 with a common center, and each arc section 52 has a guide section 51 inclined outwardly connected at the first end and a vertical section 53 connected at the second end. The two vertical sections 53 are connected by a horizontal plate 54, and the horizontal plate 54 is provided with fixing holes for fixing the elastic clamps on the culture plate 1. The above arrangement can clamp and fix the entire hollow fiber bioreactor 9 on the culture plate 1, and will not damage the hollow fiber bioreactor due to clamping too tightly. In addition, the inclined section 312 can ensure that the hollow fiber bioreactor 9 is quickly introduced into the corresponding area of the arc section 52 for fixation, and the vertical section 53 can also reserve a certain buffer space below to avoid the risk of direct contact of the hollow fiber bioreactor 9 with the culture plate 1.

[0056] In a more preferable embodiment, refer to Figure 9 A convenient adjustment structure is arranged on the culture plate 1, which includes rod-shaped structures symmetrically arranged on the culture plate 1. The rod-shaped structures can be controlled by one person to perform the hole pairing action, and one person can complete the hole insertion and locking action.

[0057] In a more preferable embodiment, the convenient adjustment structure includes two longitudinal rods 61 arranged in parallel, and a horizontal rod 62 connecting the two longitudinal rods 61. The horizontal rod 62 is arranged in the peripheral space of the culture plate 1, so that the hole pairing action can be more conveniently implemented.

[0058] More preferably, two short vertical rods 63 are arranged on both side edges of the longitudinal rod 61, and the two short vertical rods 63 form a group of short vertical rods 63, and the group of short vertical rods 63 forms a hanging space, and the hanging space can be used to hang and fix the culture plate 1 to a specific position before and after use, thereby saving space.

[0059] Finally, in use, the rotating column 13 of the culture plate 1 is arranged in the rotating groove, and the horizontal state and the inclined state are locked by using the angle adjustment and locking structure. The state maintenance and conversion can be achieved by the arrangement of the two angle adjustment and locking structures, and the effective culture of the hollow fiber bioreactor 9 is ensured.

[0060] A hollow fiber bioreactor 9 culture method uses the culture rack described above to culture one to multiple groups of hollow fiber bioreactors 9, and the hollow fiber bioreactors 9 are arranged in parallel arrays, and the number of a group of hollow fiber bioreactors 9 is the number that meets the simultaneous use of an extracorporeal liver support system at one time.

[0061] In the initial planting stage after the seed cells are filled, all the hollow fiber bioreactors 9 are maintained in a parallel array state with the ground for culture.

[0062] In the growth culture stage after the seed cells are uniformly attached to the fiber side walls of the hollow fiber bioreactors 9, all the hollow fiber bioreactors 9 are arranged at an angle of 30-60° with the ground. The seed cells are C3A cells.

[0063] The initial planting stage time is 12-24 hours, and the hollow fiber bioreactor 9 is arranged on an angle-adjustable and lockable culture rack, and the horizontal or inclined state of the culture rack is adjusted to control all the hollow fiber bioreactors 9 to meet the needs of the initial culture stage and the growth culture stage.

[0064] After the hollow fiber bioreactor 9 is arranged on the culture rack, it is fixed in the closed incubator 7, and the arrangement of the hollow fiber bioreactor 9 in the closed incubator 7 can ensure that the culture process is not affected by the external environment.

[0065] The culture tank 8 is provided with a liquid inlet and a liquid outlet connected with the outside, the liquid inlet is used to supply fresh liquid, the liquid outlet is used to output the liquid in the culture tank 8, the liquid inlet and the liquid outlet are kept in balance, the culture tank 8 is also provided with an output pipe for supplying the nutrient to the hollow fiber bioreactor 9 and an input pipe for returning the liquid from the hollow fiber bioreactor 9 to the culture tank 8. The supply of nutrient is realized by the rapid liquid circulation of the culture tank 8 in the hollow fiber bioreactor inside the incubator 7, the input of fresh liquid outside the culture tank 8 and the output of the liquid in the culture tank 8, so that the liquid in the culture tank 8 can meet the need of the supply of nutrient in the hollow fiber bioreactor 9.

[0066] The above description is made to the technical scheme in the embodiments of the present application through specific examples, obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments, the person skilled in the art can easily understand other advantages and effects of the present application from the content disclosed in the present application. The present application can also be implemented or applied through other different specific embodiments, the above embodiments and the features in the embodiments can be combined with each other in the case of no conflict, based on the embodiments in the present application, all other embodiments obtained by the person skilled in the art without creative labor belong to the protection scope of the present application.

Claims

1. A hollow fiber bioreactor culture rack, characterized by, It comprises, The culture plate is provided with rotating columns; A plurality of hollow fiber bioreactors are arranged; The support frame is provided with rotating grooves; the rotating columns of the culture plate are arranged in the rotating grooves of the support structure to realize the combination of the culture plate and the support structure and the adjustment of the angle of the culture plate, so that the culture plate can reach a horizontal state and an inclined state; The angle adjustment and locking structure is used to lock the position relationship between the culture plate and the support structure when the culture plate reaches the horizontal state or the inclined state, and to loosen the position relationship when adjustment is needed, so that the culture plate can switch between the horizontal state and the inclined state.

2. The culture shelf of claim 1, wherein The culture plate comprises a top plate and a peripheral plate, the peripheral plate is arranged around the top plate, the peripheral plate comprises a first plate and a second plate, and a rotating column is arranged on each of the first plate and the second plate, and a rotating groove accommodating the rotating column is arranged on the support frame. Preferably, the rotating groove comprises a guiding groove with a large opening at the top and an adapting groove adapted to the rotating column at the bottom, so that the culture plate can be arranged on the support frame very conveniently.

3. The culture shelf of claim 2, wherein, The support frame comprises a first support structure and a second support structure, and further comprises a transverse support structure connecting the first support structure and the second support structure, the support frame is fixed to the incubator through the transverse support structure, and a rotating groove is arranged on each of the first support structure and the second support structure.

4. The culture shelf of claim 2, wherein, The angle adjustment and locking structure is arranged on the first support structure of the support frame and the corresponding first plate or on the second support structure or the second plate, the angle adjustment and locking structure comprises a threaded rotating column and a locking nut sleeved on the rotating column, the first support structure and the corresponding first plate or the second support structure and the corresponding second plate are in close contact to realize locking by rotating the locking nut along the rotating column, and the close contact locking relationship is released in reverse rotation to realize angle adjustment.

5. The culture shelf of claim 4, wherein, A horizontal blocking protrusion and an inclined blocking protrusion are arranged on both sides of the inclined section, the culture plate reaches the horizontal state when the adjusting plate touches the horizontal blocking protrusion, and the culture plate is locked in the horizontal state by tightening the locking nut; the culture plate reaches the inclined state when the adjusting plate touches the inclined blocking protrusion, and the culture plate is locked in the inclined state by tightening the locking nut.

6. The culture shelf of claim 2, wherein, The angle adjustment and locking structure comprises a extending plate arranged on the first plate and / or the second plate, two locking holes one arranged on the extending plate in the horizontal state and the inclined state, a locking hole two arranged on one of the first support structure and the second support structure and matched with the locking hole one, and a locking rod arranged outside the rotating groove. Preferably, the distance from the two locking holes one to the axis of the rotating column is equal, and the locking hole two is arranged on a locking plate outside the rotating groove.

7. The culture shelf of claim 6, wherein, The rotating column is arranged at the middle position of the culture plate, the culture plate is a face-symmetrical figure, the central axis of the rotating column is on the longitudinal symmetry plane, and two groups of locking holes one are arranged on the first plate and the second plate with the longitudinal symmetry plane as a mirror plane.

8. The culture shelf of claim 6, wherein, The first support structure and the second support structure both comprise a vertical section and an inclined section, the inclined section is inclined upward; the vertical section is used to connect the transverse support structure, the inclined section is provided with a rotating groove, and the inclined section of one of the first support structure and the second support structure is provided with a second locking hole which is inclined downward, and the angle of the downward inclination of the second locking hole is the same as the angle of the inclined state of the culture plate.

9. The culture shelf of claim 6, wherein, The diameter of the first locking hole is smaller than that of the second locking hole, and a first locking section matched with the first locking hole and a second locking section matched with the second locking hole are arranged on the locking rod; Preferably, the second end of the second locking section is connected with the first locking section, and the second end of the second locking section is provided with a holding operation section. Preferably, a protection ring with a diameter larger than that of the holding operation section is arranged at both ends of the holding operation section.

10. The culture shelf of claim 2, wherein, A convenient adjustment structure is arranged on the culture plate, the convenient adjustment structure comprises symmetrically arranged rod-shaped structures on the culture plate, the convenient adjustment structure comprises two longitudinally arranged longitudinal rods, and further comprises a transverse rod connecting the two longitudinal rods, and the transverse rod is arranged in the peripheral space of the culture plate; Preferably, two short vertical rods are arranged on the two side edges of the longitudinal rod, and the two short vertical rods form a group, and a hanging space is formed by the group of short vertical rods.

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