Medical intermediate sampling device

Abstract

The utility model relates to the technical field of sampling, in particular to a medical intermediate sampling device. The front end of the main pipe is communicated with a reaction kettle; a sampling pump is mounted on the main pipe; a first electromagnetic valve is mounted on the main pipe on the rear side of the sampling pump; the rear end of the main pipe is fixedly communicated with a first end of a four-way joint; the flushing pipe is communicated with the water tank, a third electromagnetic valve and a flushing pump are mounted on the flushing pipe, a sampling pipe is fixedly communicated with the fourth end of the four-way joint, a second electromagnetic valve is mounted on the sampling pipe, the main pipe is fixedly communicated with an upper pipe, the upper pipe, a return pipe and a lower pipe are communicated, a fifth electromagnetic valve is mounted on the upper pipe, and a sixth electromagnetic valve is mounted on the return pipe; and a seventh electromagnetic valve is mounted on the lower pipe. According to the utility model, residues in the sampling pipeline can be reduced, so that the detection precision is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to a sampling technical field, concretely relates to a medicine intermediate sampling device. BACKGROUND

[0002] 2-amino-3-methylbenzoic acid, also known as 2-amino-3-methylbenzoic acid, 3-methyl anthranilic acid or 2-amino 3-methylbenzoic acid, is easily soluble in ethanol and diethyl ether. 2-amino-3-methylbenzoic acid can be used as an intermediate for synthesizing drugs. 2-amino-3-methylbenzoic acid also plays an important role in the field of pesticides. It is an important intermediate for synthesizing new pesticides such as chlorantraniliprole. Chlorantraniliprole is a new type of insecticide with high insecticidal effect and broad-spectrum killing ability against lepidopteran pests.

[0003] The synthesis method of 2-amino-3-methylbenzoic acid is: adding ethanol solvent, 3-methyl-2-nitrobenzoic acid, catalyst, ethanolamine into the reaction kettle in turn, heating to 80℃, and then keeping the hydrogen pressure at 1.0MPa to start the reaction. The reaction is completed after 60min. Open the reaction kettle for sampling and liquid chromatography analysis. Sampling detection during the synthesis of 2-amino-3-methylbenzoic acid is an important step. The installation position of some reaction kettles is not convenient for adjacent sampling, so it is necessary to set up a sampling pipeline connected with the reaction kettle. Through the setting of the sampling pipeline, sampling detection can be conveniently carried out, and the efficiency of sampling detection can be improved.

[0004] The patent document with publication number CN217688041U discloses a sampling device in a solid-liquid mixing system, which can sample the mixed liquid in the mixing tank through the hollow stirring rod and the height-adjustable collection tank, improving the sampling efficiency. However, in the above-mentioned patent, although the sampling efficiency is improved, there are still some problems. After sampling is completed, there are still some medical intermediates remaining in the sampling device, which will affect the sampling of the next medical intermediate if not removed,

[0005] To solve the above technical problems, the patent document with publication number CN219434426U discloses a kind of medical intermediates sampler, including storage tank, the output of the storage tank is equipped with discharge port, the discharge port is used for the sampling of medical intermediates;Sampling assembly, the sampling assembly is communicated with the discharge port, the sampling assembly is used for the sampling of medical intermediates, the sampling assembly has pump body;Cleaning assembly, the cleaning assembly is communicated with the sampling assembly, the cleaning assembly is used to clean the sampling assembly;The pump body is communicated with the discharge port to sample medical intermediates, and the pump body is communicated with the cleaning assembly to clean the sampling assembly.The sampler can flush sampling pipeline after sampling, but after flushing sampling pipeline, flushing liquid is easily retained in the sampling pipeline, which can mix with the product during the next sampling, thereby affecting the accuracy of detection results. Utility model content

[0006] The main purpose of the utility model is to provide a kind of medical intermediates sampling device which can reduce the residue in sampling pipeline and improve detection accuracy.

[0007] To achieve the above purpose, the technical scheme provided by the utility model is:

[0008] A kind of medical intermediates sampling device, including the main pipe of front end and reaction kettle communication, sampling pump is installed on main pipe, first electromagnetic valve is installed on the main pipe of sampling pump rear side, the first end of four-way is fixedly communicated with the main pipe rear end, the second end of four-way is communicated with blowpipe, blowpipe is communicated with air pump, fourth electromagnetic valve is installed on blowpipe, flushing pipe is fixedly communicated on the third end of four-way, flushing pipe is communicated with water tank, third electromagnetic valve and flushing pump are installed on flushing pipe, sampling tube is fixedly communicated on the fourth end of four-way, second electromagnetic valve is installed on sampling tube, the main pipe of four-way and first electromagnetic valve is fixedly communicated with upper pipe on the lower side, the first end of three-way is communicated with lower end of upper pipe, the second end of three-way is communicated with return pipe, the third end of three-way is communicated with lower pipe, lower pipe is communicated with collection tank, fifth electromagnetic valve is installed on upper pipe, sixth electromagnetic valve is installed on return pipe, seventh electromagnetic valve is installed on lower pipe.

[0009] Specifically, the outlet end of the return pipe and the outlet end of the sampling pipe are located above the collection tank.

[0010] Specifically, the outer edge of the lower end of the sampling pipe is processed with external thread.

[0011] Specifically, the upper end of the collection tank is provided with an exhaust hole.

[0012] Specifically, the sampling pump is electrically connected with the controller through the first control module, the flushing pump is electrically connected with the controller through the second control module, the air pump is electrically connected with the controller through the third control module, the input module of the controller is electrically connected with the control panel, and the output module of the controller is electrically connected with the first electromagnetic valve, the second electromagnetic valve, the third electromagnetic valve, the fourth electromagnetic valve, the fifth electromagnetic valve, the sixth electromagnetic valve and the seventh electromagnetic valve.

[0013] Compared with the prior art, the utility model has the advantages that:

[0014] 1. The water pump and the air pump communicated with the main pipe are arranged, the main pipe can be flushed and purged, the residual medical intermediates in the main pipe can be removed, and the accuracy of the next sampling detection result can be ensured.

[0015] 2. The collecting box is arranged, and the collecting box is communicated with the main pipe through the upper pipe, the lower pipe and the three-way pipe, the medical intermediates in the main pipe can be recycled, and waste can be avoided.

[0016] 3. The collecting groove is arranged, the water for flushing the main pipe and the sampling pipe can be collected, and the water for flushing the main pipe and the sampling pipe can be prevented from falling to the ground and polluting the environment. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is a schematic view of the sampling device connected with the reaction kettle.

[0018] Figure 2 It is a schematic view of the sampling device.

[0019] Figure 3 It is a frame of the control structure of the utility model.

[0020] The names of the parts in the drawings are: 1, reaction kettle, 2, main pipe, 3, first electromagnetic valve, 4, sampling pump, 5, four-way pipe, 6, sampling pipe, 7, second electromagnetic valve, 8, flushing pipe, 9, third electromagnetic valve, 10, flushing pump, 11, water tank, 12, blowing pipe, 13, fourth electromagnetic valve, 14, air pump, 15, upper pipe, 16, fifth electromagnetic valve, 17, three-way pipe, 18, return pipe, 19, lower pipe, 20, sixth electromagnetic valve, 21, seventh electromagnetic valve, 22, collecting box, 23, collecting groove. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments.

[0022] Embodiment one: refer to Figures 1-3The utility model discloses a medical intermediate sampling device, including the main pipe 2 of front end with the communication of reactor 1, install sampling pump 4 on the main pipe 2, install first solenoid valve 3 on the rear side of sampling pump 4.

[0023] The rear end of the main pipe 2 is fixedly communicated with the first end of the four-way joint 5. The second end of the four-way joint 5 is communicated with a blowing pipe 12, the blowing pipe 12 is communicated with a gas pump 14, and the blowing pipe 12 is provided with a fourth solenoid valve 13.

[0024] The third end of the four-way joint 5 is fixedly communicated with a flushing pipe 8, the flushing pipe 8 is communicated with a water tank 11, and the flushing pipe 8 is provided with a third solenoid valve 9 and a flushing pump 10.

[0025] The fourth end of the four-way joint 5 is fixedly communicated with a sampling pipe 6, an outer thread is formed at the lower edge of the sampling pipe 6, and the sampling pipe 6 is provided with a second solenoid valve 7.

[0026] The lower side of the main pipe 2 between the four-way joint 5 and the first solenoid valve 3 is fixedly communicated with an upper pipe 15, the lower end of the upper pipe 15 is communicated with the first end of a three-way joint 17, the second end of the three-way joint 17 is communicated with a return pipe 18, and the third end of the three-way joint 17 is communicated with a lower pipe 19.

[0027] The lower pipe 19 is communicated with a collection tank 22, and an exhaust hole is formed in the upper end of the collection tank 22.

[0028] The fifth solenoid valve 16 is arranged on the upper pipe 15, the sixth solenoid valve 20 is arranged on the return pipe 18, and the seventh solenoid valve 21 is arranged on the lower pipe 19.

[0029] The sampling pump 4 is electrically connected with the controller through a first control module, the flushing pump 10 is electrically connected with the controller through a second control module, the gas pump 14 is electrically connected with the controller through a third control module, the input module of the controller is electrically connected with the control panel, and the output module of the controller is electrically connected with the first solenoid valve 3, the second solenoid valve 7, the third solenoid valve 9, the fourth solenoid valve 13, the fifth solenoid valve 16, the sixth solenoid valve 20 and the seventh solenoid valve 21.

[0030] The first solenoid valve 3, the second solenoid valve 7, the third solenoid valve 9, the fourth solenoid valve 13, the fifth solenoid valve 16, the sixth solenoid valve 20 and the seventh solenoid valve 21 are all normally closed solenoid valves.

[0031] When sampling, the sampling bottle is threadedly and sealingly connected with the lower end of the sampling pipe 6, and an exhaust hole is arranged at the upper end of the sampling bottle.

[0032] The controller is inputted a sampling command through the control panel, and the controller opens the second electromagnetic valve 7 and the first electromagnetic valve 3 while starting the sampling pump 4. After the sampling pump 4 is started, the pharmaceutical intermediates in the reaction kettle 1 enter the sampling bottle through the sampling pump 4, the main pipe 2, the four-way pipe 5 and the sampling pipe 6. After the sampling is completed, the controller closes the sampling pump 4, the first electromagnetic valve 3 and the second electromagnetic valve 7.

[0033] Then the controller is inputted a cleaning command through the control panel, and the controller opens the seventh electromagnetic valve 21, the fifth electromagnetic valve 16, the fourth electromagnetic valve 13 and the air pump 14. The pharmaceutical intermediates in the main pipe 2 and the four-way pipe 5 enter the collection tank 22 through the upper pipe 15, the lower pipe 19 and the three-way pipe 17, thereby recycling the pharmaceutical intermediates remaining in the main pipe 2 and the four-way pipe 5.

[0034] After the set time, the controller closes the seventh electromagnetic valve 21, the fifth electromagnetic valve 16, the fourth electromagnetic valve 13 and the air pump 14. Then the controller opens the sixth electromagnetic valve 20, the fifth electromagnetic valve 16, the second electromagnetic valve 7, the third electromagnetic valve 9 and the flushing pump 10. The flushing pump 10 pumps out the water in the water tank 11, and part of the water is discharged through the flushing pipe 8, the four-way pipe 5 and the sampling pipe 6, and the other part of the water is discharged through the main pipe 2, the upper pipe 15, the three-way pipe 17 and the return pipe 18, thereby flushing the part of the main pipe 2 between the first electromagnetic valve 3 and the four-way pipe 5, the inside of the four-way pipe 5 and the sampling pipe 6.

[0035] After the set time of flushing the part of the main pipe 2 between the first electromagnetic valve 3 and the four-way pipe 5, the inside of the four-way pipe 5 and the sampling pipe 6, the controller closes the flushing pump 10 and the third electromagnetic valve 9, and keeps the second electromagnetic valve 7, the sixth electromagnetic valve 20 and the fifth electromagnetic valve 16 open. Then the controller opens the fourth electromagnetic valve 13 and the air pump 14. The air pump 14 makes part of the compressed air discharged through the four-way pipe 5 and the sampling pipe 6, and the other part of the compressed air discharged through the part of the main pipe 2 behind the first electromagnetic valve 3, the upper pipe 15, the three-way pipe 17 and the return pipe 18, thereby purging the part of the main pipe 2 behind the first electromagnetic valve 3, the sampling pipe 6 and the four-way pipe 5 which have been cleaned.

[0036] After the set time of purging the part of the main pipe 2 behind the first electromagnetic valve 3, the sampling pipe 6 and the four-way pipe 5 which have been cleaned, the controller closes the air pump 14, the fourth electromagnetic valve 13, the second electromagnetic valve 7, the fifth electromagnetic valve 16 and the sixth electromagnetic valve 20.

[0037] Example Two: Based on Example One, referring to Figure 1 and Figure 2 It is shown that the outlet end of the return pipe 18 and the outlet end of the sampling pipe 6 are located above the collection tank 23.

[0038] The water for flushing the portion of the main pipe 2 between the first electromagnetic valve 3 and the four-way valve 5, the inside of the four-way valve 5 and the sampling pipe 6 can flow into the collecting groove 23 for collection, preventing the water for flushing the portion of the main pipe 2 between the first electromagnetic valve 3 and the four-way valve 5, the inside of the four-way valve 5 and the sampling pipe 6 from flowing to the ground to pollute the environment.

[0039] The above merely describes the preferred embodiments of the present application, and is not intended to limit the present application, and any modification, equivalent replacement and improvement within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A pharmaceutical intermediate sampling device comprising a main pipe (2) having a front end communicating with a reactor (1), characterized in that, The main pipe (2) is provided with a sampling pump (4) installed thereon, and a first electromagnetic valve (3) installed on the rear side of the sampling pump (4). The rear end of the main pipe (2) is fixedly communicated with a first end of a four-way pipe (5), and a second end of the four-way pipe (5) is communicated with a blowing pipe (12) communicated with an air pump (14). The blowing pipe (12) is provided with a fourth electromagnetic valve (13) installed thereon. A flushing pipe (8) is fixedly communicated with a third end of the four-way pipe (5), and the flushing pipe (8) is communicated with a water tank (11). The flushing pipe (8) is provided with a third electromagnetic valve (9) and a flushing pump (10) installed thereon. A sampling pipe (6) is fixedly communicated with a fourth end of the four-way pipe (5), and the sampling pipe (6) is provided with a second electromagnetic valve (7) installed thereon. A upper pipe (15) is fixedly communicated with the lower side of the main pipe (2) between the four-way pipe (5) and the first electromagnetic valve (3). The lower end of the upper pipe (15) is communicated with a first end of a three-way pipe (17), and a second end of the three-way pipe (17) is communicated with a return pipe (18). A third end of the three-way pipe (17) is communicated with a lower pipe (19), and the lower pipe (19) is communicated with a collecting tank (22). The upper pipe (15) is provided with a fifth electromagnetic valve (16) installed thereon. The return pipe (18) is provided with a sixth electromagnetic valve (20) installed thereon. The lower pipe (19) is provided with a seventh electromagnetic valve (21) installed thereon.

2. The medical intermediate sampling device of claim 1, wherein, The outlet end of the return pipe (18) and the outlet end of the sampling pipe (6) are located above the collecting groove (23).

3. The medical intermediate sampling device of claim 1, wherein, An outer thread is processed on the lower end of the sampling pipe (6).

4. The medical intermediate sampling device of claim 1, wherein, An exhaust hole is formed on the upper end of the collecting tank (22).

5. The medical intermediate sampling device of claim 1, wherein, The sampling pump (4) is electrically connected with the controller through a first control module, the flushing pump (10) is electrically connected with the controller through a second control module, and the air pump (14) is electrically connected with the controller through a third control module. The input module of the controller is electrically connected with the control panel, and the output module of the controller is electrically connected with the first electromagnetic valve (3), the second electromagnetic valve (7), the third electromagnetic valve (9), the fourth electromagnetic valve (13), the fifth electromagnetic valve (16), the sixth electromagnetic valve (20) and the seventh electromagnetic valve (21).

6. The medical intermediate sampling device of claim 5, wherein, The first electromagnetic valve (3), the second electromagnetic valve (7), the third electromagnetic valve (9), the fourth electromagnetic valve (13), the fifth electromagnetic valve (16), the sixth electromagnetic valve (20) and the seventh electromagnetic valve (21) are all normally closed electromagnetic valves.

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