Sample treatment detection device and sample treatment device

Abstract

The utility model relates to the technical field of in vitro diagnosis, and discloses a sample processing and detecting device and a sample processing device.The sample processing device comprises a sample processing module, a sample adding channel and a plurality of solution bins, and magnetic beads used for adsorbing nucleic acid or protein are arranged in at least one solution bin; the bottom of the solution bin is communicated with a closed pipette, and the pipette is provided with a sealing gasket; the liquid driving device is arranged in the sample processing module, and a syringe needle at the bottom of the liquid driving device can be inserted into the sealing gasket; at least one of the liquid driving device and the solution bin moves relatively under the driving of the power mechanism, so that the syringe needle of the liquid driving module is inserted into the pipette channels corresponding to different solution bins. The sample treatment device is high in pipetting efficiency, capable of improving the detection efficiency, compact in structure, small in size and wide in application range.

Description

Technical Field

[0001] This utility model relates to the field of in vitro diagnostic technology, and more specifically, to a sample processing device. This utility model also provides a sample processing and detection device including the above-described sample processing device. Background Technology

[0002] Currently, in vitro diagnostic testing requires multiple pipetting operations on samples, reagents, and reactants to complete the testing process. This numerous pipetting operations not only increase the workload but also reduce testing efficiency.

[0003] To improve pipetting efficiency, existing technologies employ compressible tubing with several reaction zones containing different reagents. These zones are connected by thermal bonding to separate them. When a reaction zone is mechanically compressed, the reagents move within it under the pressure, allowing for reagent movement between different zones. While this compressible tubing improves pipetting efficiency, it only supports 4-5 PCR assays. For multiplex quantitative PCR or CRP blood tests, the number of compressible tubing units or reaction zones within the tubing must be increased, resulting in poor adaptability.

[0004] In summary, developing a sample processing device that is widely applicable and can improve detection efficiency is a problem that urgently needs to be solved by those skilled in the art. Utility Model Content

[0005] In view of this, the purpose of this utility model is to provide a sample processing device that has high pipetting efficiency, can improve detection efficiency, and has a compact structure, small size, and wide applicability.

[0006] In addition, this utility model also provides a sample processing and detection device including the above-mentioned sample processing device.

[0007] To achieve the above objectives, this utility model provides the following technical solution:

[0008] A sample processing and detection device, comprising:

[0009] The sample processing module is provided with a sample addition channel and several solution chambers. At least one of the solution chambers is provided with magnetic beads for adsorbing nucleic acids or proteins, and the bottom of the solution chamber is connected to a closed pipetting pipe with a sealing gasket.

[0010] The liquid drive module installed in the sample processing module has a syringe needle at its bottom that can be inserted into the sealing gasket.

[0011] At least one of the liquid drive module and the solution chamber is moved relative to each other under the drive of the power mechanism, so that the syringe needle of the liquid drive module can be inserted into the pipetting tube corresponding to different solution chambers.

[0012] Preferably, the liquid driving module includes a syringe mounting bracket and a syringe. The syringe is fitted into the syringe mounting hole of the sample processing module through the syringe mounting bracket. The syringe mounting bracket is threadedly connected to the syringe mounting hole, and the syringe is snapped into the syringe mounting bracket.

[0013] Preferably, the syringe includes an eccentric syringe with an eccentrically positioned syringe needle, the eccentric syringe being located in the center of the sample processing module, the solution chamber and the pipetting tubing being evenly distributed along the circumference of the sample processing module, and the pipetting tubing being located on the side of the solution chamber relatively close to the eccentric syringe.

[0014] Preferably, the sealing gasket used to seal each of the pipetting channels is an integrally formed annular sealing gasket, and the annular sealing gasket has a downwardly recessed sealing portion at the position corresponding to each of the pipetting channels.

[0015] Preferably, the bottom of the sample processing module is provided with a limiting groove, and the outer edge of the annular sealing gasket is provided with a limiting part for engaging with the limiting groove.

[0016] Preferably, the sample processing module is provided with a rotary motor at its bottom, which can drive the sample processing module to step relative to the eccentric syringe. The stepping angle of the rotary motor is the same as the central angle of the two adjacent solution chambers.

[0017] Preferably, the top of the solution chamber is provided with a sealing cover, and a filter element is provided inside the sealing cover. The filter element is used to maintain the internal and external air pressure balance of the solution chamber and to prevent liquid from entering the solution chamber.

[0018] Preferably, the sealing caps of each of the solution chambers are integral structures.

[0019] A sample processing and detection device includes a sample processing component, a magnetic control component, and a detection module, wherein the sample processing component is any of the sample processing modules described above.

[0020] Preferably, the magnetic control component includes an electromagnet sleeved outside the solution chamber. When the electromagnet is energized, it attracts the magnetic bead to the top of the solution chamber, thereby separating the magnetic bead from the solution.

[0021] When the electromagnet is de-energized, the magnetic bead is located in the middle or bottom of the solution chamber, so that the magnetic bead is immersed in the solution.

[0022] The sample processing device provided by this utility model utilizes the relative movement of the liquid driving module and the sample processing module to insert the syringe needle into the pipetting tube corresponding to different solution chambers, thereby realizing the pipetting of different types of solutions. Compared with the existing mechanical squeezing pipetting method, it has high pipetting efficiency, simple structure, and strong adaptability.

[0023] A magnetic field is used to drive magnetic beads to move within a solution chamber, changing the contact state between the magnetic beads and the solution. This allows the substances adhering to the surface of the magnetic beads to react with the solution, or it separates the magnetic beads from the solution to facilitate the transfer of the solution within the chamber.

[0024] In addition, this utility model also provides a sample processing and detection device including the above-mentioned sample processing device. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0026] Figure 1 A schematic diagram of a specific embodiment of the sample processing and detection device provided by this utility model;

[0027] Figure 2 for Figure 1 Schematic cross-section in the AA direction;

[0028] Figure 3 A schematic diagram illustrating the detection principle of the sample processing and detection device provided by this utility model applied to CRP blood routine testing;

[0029] Figure 4 This is a schematic diagram illustrating the detection principle of the sample processing and detection device provided by this utility model applied to PCR detection.

[0030] Figure label:

[0031] 1-Sample processing module; 11-Solution chamber; 12-Pipette; 2-Instrument mounting bracket; 3-Eccentric syringe; 4-Sealing gasket; 5-Magnetic bead; 6-Sample outlet; 7-Magnetic control assembly. Detailed Implementation

[0032] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0033] The core of this utility model is to provide a sample processing device that has high pipetting efficiency, can improve detection efficiency, and has a compact structure, small size, and wide applicability.

[0034] This utility model also provides a sample processing and detection device including the above-mentioned sample processing device.

[0035] The sample processing and testing device provided by this utility model includes:

[0036] The sample processing module 1 is provided with a sample addition channel and several solution chambers 11. At least one solution chamber 11 is provided with magnetic beads 5 for adsorbing nucleic acids or proteins, and the bottom of the solution chamber 11 is connected to a closed pipetting pipe 12, which is provided with a sealing gasket 4.

[0037] The liquid drive module installed in the sample processing module 1 has a syringe needle at its bottom that can be inserted into the sealing gasket 4;

[0038] At least one of the liquid driving module and the sample processing module 1 moves relative to each other under the drive of the power mechanism, so that the syringe needle of the liquid driving module can be inserted into the pipetting tube 12 corresponding to different solution chambers 11.

[0039] The sample processing module 1 is used to hold various reagents required for sample testing, such as lysis buffer, washing buffer, amplification buffer, antibody and luminescent substrate. To avoid reagent contamination, each reagent is placed in a different solution chamber 11. The specific number and volume of the solution chambers 11 are determined according to the types and amounts of reagents required for in vitro diagnostic testing in actual production, so as to ensure the normal operation of in vitro diagnostic testing.

[0040] Since nucleic acids or proteins need to be adsorbed and enriched in in vitro diagnostic tests for subsequent detection, at least one solution chamber 11 of the sample processing module 1 is provided with magnetic beads 5 for adsorbing nucleic acids or proteins. The magnetic beads 5 can be nucleic acid purification magnetic beads, immunomagnetic beads, etc. The specific type of magnetic beads 5 is determined according to the type of in vitro diagnostic test. For example, nucleic acid purification magnetic beads can be used for PCR testing, while immunomagnetic beads can be used for CRP blood routine testing.

[0041] The sample processing module 1 has a sample dispensing channel connected to a solution chamber 11 equipped with magnetic beads 5, so that the magnetic beads 5 can adsorb the nucleic acid or protein and other reactants obtained from the sample lysis reaction. The sample dispensing channel can be set as an independent channel of the sample processing module 1, but it is preferred to set the sample dispensing channel and the solution chamber 11 as an integrated structure in order to simplify the structure of the sample processing module 1 and reduce production costs.

[0042] Considering the environmental requirements for sample testing, when the sample addition channel and solution chamber 11 are integrated, it is preferable that the top of the solution chamber 11 is provided with a sealing cover, and a filter element is provided inside the sealing cover. The filter element is used to maintain the internal and external air pressure balance of the solution chamber 11 and to prevent liquid from entering the solution chamber 11.

[0043] The specific materials of the sealing cap and filter element are determined according to the actual testing needs, and will not be elaborated here. The sealing caps of each solution chamber 11 can be set independently, but it is preferable to set the sealing caps of each solution chamber 11 as an integrated structure in order to simplify the structure of the sample processing module 1 and facilitate processing and manufacturing.

[0044] To facilitate the placement and removal of the sealing cap, the outer edge of the sealing cap is provided with a protruding grip. The grip is used to facilitate the testing personnel to apply force to the sealing cap, thereby placing the sealing cap into the solution chamber 11 or lifting the sealing cap on the top of the solution chamber 11.

[0045] The magnetic bead 5 can move within the solution chamber 11 under the drive of the magnetic field, changing the contact state between the magnetic bead 5 and the solution in the solution chamber 11, thereby facilitating the transfer of reagents and the reaction between the sample and the reagent. When the magnetic bead 5 moves to the top of the solution chamber 11 under the action of the magnetic field, the magnetic bead 5 can separate from the solution in the solution chamber 11, making it convenient for the syringe needle to draw up and transfer the solution in the solution chamber 11.

[0046] When the magnetic bead 5 moves to the lower middle part of the solution chamber 11 under the action of the magnetic field, the magnetic bead 5 is immersed in the solution in the solution chamber 11, and the nucleic acid, protein or antigen-antibody reactants adsorbed by the magnetic bead 5 can react with the solution.

[0047] In order to realize the transfer of reagents and reactants between different solution chambers 11, the bottom of the solution chamber 11 is provided with a pipetting tube 12 sealed by a sealing gasket 4. At least one of the solution chambers 11 of the liquid drive module and the sample processing module 1 can move under the drive of the power mechanism, so that the liquid drive module and the sample processing module 1 move relative to each other, thereby allowing the syringe needle of the liquid drive module to be inserted into the pipetting tube 12 corresponding to the different solution chambers 11.

[0048] The structure, size, and distribution of the pipetting channels 12 are determined based on the relative movement mode and range of movement of the liquid drive module and the sample processing module 1 in actual production, so as to ensure that the syringe needle of the liquid drive module can be inserted into the pipetting channel 12 corresponding to each solution chamber 11 and pipetting is performed on each solution chamber 11.

[0049] The relative movement between the liquid drive module and the sample processing module 1 can be horizontal movement, rotational movement, or a combination of both.

[0050] Considering the layout and size of the sample processing and detection device, it is preferable to set the liquid driving module and the sample processing module 1 to rotate relative to each other. At this time, the syringe of the liquid driving module can be located inside each solution chamber 11 of the sample processing module 1. This not only makes the sample processing and detection device compact, but also reduces the movement distance of the syringe, which is conducive to improving the liquid transfer efficiency and thus improving the detection operation efficiency.

[0051] For example, please refer to Figure 2 The syringe includes an eccentric syringe 3 with an eccentrically set syringe needle. The eccentric syringe 3 is located in the center of the sample processing module 1. The solution chamber 11 and the pipetting tube 12 are evenly distributed along the circumference of the sample processing module 1. The pipetting tube 12 is located on the side of the solution chamber 11 that is relatively close to the eccentric syringe 3.

[0052] The liquid drive module includes a syringe mounting bracket 2 and a syringe. In order to stably install the syringe in the sample processing module 1, it is preferable to set the syringe to be fitted into the syringe mounting hole of the sample processing module 1 through the syringe mounting bracket 2. The syringe mounting bracket 2 is threadedly connected to the syringe mounting hole, and the syringe is snapped into the syringe mounting bracket 2.

[0053] The dimensions of the syringe mounting bracket 2 are determined based on the dimensions of the syringe mounting hole in the sample processing module 1 and the dimensions of the syringe in actual production, and will not be elaborated here.

[0054] Considering the overall layout of the sample processing and detection device, the bottom of the sample processing module 1 is also provided with a sample outlet 6. The sample outlet 6 corresponds to the solution chamber 11, which serves as a sample and reagent reaction container. The sample outlet 6 can be used in conjunction with the detection module for detection, or the sample can enter the detection module for detection through the sample outlet 6.

[0055] The type and model of the power mechanism are determined according to the relative movement of the liquid drive module and the sample processing module 1. For example, when the two move horizontally relative to each other, the power mechanism can be set as a linear motor, electric push rod, etc.; when the two rotate relative to each other, the power mechanism can be set as a servo motor, stepper motor, etc.

[0056] In this embodiment, by utilizing the relative movement of the liquid driving module and the sample processing module 1, the syringe needle is inserted into the pipetting tube 12 corresponding to different solution chambers 11, thereby realizing the pipetting of different types of solutions. Compared with the existing mechanical squeezing pipetting method, the pipetting efficiency is high, and the structure is simple and highly adaptable.

[0057] The magnetic bead 5 is driven to move within the solution chamber 11 by a magnetic field, which changes the contact state between the magnetic bead 5 and the solution, thereby causing the surface deposits of the magnetic bead 5 to react with the solution, or causing the magnetic bead 5 to separate from the solution so as to transfer the solution within the solution chamber 11.

[0058] Based on the above embodiments, in order to effectively seal the pipetting channels 12, the sealing gaskets 4 used to seal each pipetting channel 12 are integrally formed annular sealing gaskets, and the annular sealing gaskets have downwardly recessed sealing portions at the positions corresponding to each pipetting channel 12.

[0059] The material of the annular sealing gasket is determined based on the sealing components commonly used in in vitro diagnostic testing equipment in actual production, in order to ensure its sealing performance and corrosion resistance. The radius of the annular sealing gasket should be greater than or equal to the distance from the inner side of the solution chamber 11 to the sample processing module 1.

[0060] The shape and size of the sealing part are determined according to the shape and size of the pipetting pipe 12 in actual production.

[0061] In this embodiment, an integrally formed annular sealing gasket is used to seal each pipetting channel 12 simultaneously. Compared with each sealing gasket 4 independently sealing each pipetting channel 12, the annular sealing gasket has a larger contact area with the sample processing module 1, resulting in better sealing performance. Furthermore, the assembly process of the sealing gasket 4 is simpler.

[0062] Preferably, in order to further improve the sealing performance of the annular sealing gasket, the bottom of the sample processing module 1 can be provided with a limiting groove, and the outer edge of the annular sealing gasket can be provided with a limiting part for engaging with the limiting groove.

[0063] The aforementioned limiting groove can be an arc-shaped groove, but it is preferred to set it as an annular groove. The sealing area of ​​the annular groove is larger and the sealing effect is better than that of the arc-shaped groove. The specific cross-sectional structure and dimensions of the limiting groove are determined according to the actual production needs, and will not be elaborated here.

[0064] Based on the above embodiments, when the solution chamber 11 and the corresponding pipetting pipe 12 are evenly distributed along the circumferential direction of the sample processing module 1, in order to drive the sample processing module 1 to rotate, a rotary motor is provided at the bottom of the sample processing module 1. The rotary motor can drive the sample processing module 1 to step relative to the eccentric syringe 3. The stepping angle of the rotary motor is the same as the central angle of the two adjacent solution chambers 11.

[0065] In this embodiment, the sample processing module 1 is driven to rotate by a rotary motor, which not only facilitates the setting of the power mechanism and simplifies the power connection structure, but also ensures that the eccentric syringe 3 and the sealing gasket 4 are accurately aligned after stepping, thus avoiding the problem that the eccentric syringe 3 fails to be inserted into the pipetting tube 12.

[0066] In addition to the sample processing device described above, this utility model also provides a sample processing and detection device that includes the sample processing device disclosed in the above embodiments. The sample processing and detection device includes a sample processing component, a magnetic control component 7, and a detection module. The sample processing component is the sample processing device disclosed in the above embodiments.

[0067] The magnetic control component 7 is used to generate a magnetic field and use the change in the magnetic field to drive the magnetic bead 5 to move in the solution chamber 11 of the sample processing module 1. The change in the magnetic field can be a change in the magnetic field strength or a change in the magnetic field direction.

[0068] For example, the magnetic control component 7 can be configured to include an electromagnet fitted outside the solution chamber 11. When the electromagnet is energized, it attracts the magnetic bead 5 to the top of the solution chamber 11, thus separating the magnetic bead 5 from the solution.

[0069] When the electromagnet is de-energized, the magnetic bead 5 is located in the middle or bottom of the solution chamber 11, so that the magnetic bead 5 is immersed in the solution.

[0070] The specific type and power of the electromagnet are determined based on the material, size, and quantity of the magnetic beads 5 in actual production, to ensure that the magnetic field generated by the electromagnet can attract all the magnetic beads 5.

[0071] The aforementioned magnetic control component 7 uses an electromagnet as the magnetic control component 7. The presence or absence of a magnetic field is controlled by energizing and de-energizing the electromagnet, thereby driving the magnetic bead 5 to move within the solution chamber 11. The structure is simple and the control is convenient.

[0072] In addition to changing the energization state of the electromagnet to control the presence or absence of the magnetic field, the strength of the magnetic field can also be affected by moving the position of the magnetic field. For example, a linear motion mechanism such as a linear motor can be set up to drive the electromagnet or ordinary magnet to move relative to the solution tank 11 in the vertical or radial direction. The adsorption and release of the magnetic beads 5 can be achieved by the approach and departure of the electromagnet or ordinary magnet.

[0073] Of course, the magnetic field of the magnetic control component 7 can also be set to always exist. By switching the direction of the magnetic field and changing the direction of the magnetic force on the magnetic bead 5, the magnetic bead 5 can be driven to move in the solution chamber 11.

[0074] The structure and distribution of the detection module need to be determined based on the function of the sample processing and detection device. For example, PMT (photomultiplier tube) elements are used for fluorescence detection of proteins in CRP routine blood tests, while MPPC (multi-pixel photon counter) elements are used for multiplex fluorescence measurement of PCR in multiplex quantitative PCR tests.

[0075] In a specific embodiment, please refer to Figure 3 The sample processing module 1 has six solution chambers 11. Five of the solution chambers 11 contain lysis buffer, first washing buffer, antibody, second washing buffer and luminescent substrate in sequence. The solution chambers 11 without reagents are used as waste liquid chambers. A PMT element is provided outside the sample outlet 6 at the bottom of the sample processing module 1.

[0076] When testing is required, the sample enters the No. 1 solution chamber containing the lysis buffer through the sample addition channel. Under the action of the lysis buffer, the sample is lysed to reveal the C-reactive protein structure.

[0077] After the pyrolysis is completed, the magnetic control component 7 is controlled to move the magnetic bead 5 to the top of the No. 1 solution chamber. Then, the eccentric injector 3 is controlled to draw the pyrolysis liquid in the No. 1 solution chamber and transfer it to the waste liquid chamber. Then, the eccentric injector 3 is controlled to draw the first cleaning liquid in the No. 2 solution chamber and transfer it to the No. 1 solution chamber.

[0078] After the first cleaning solution is transferred, the magnetic control component 7 is controlled to move the magnetic bead 5 to the lower middle part of the No. 1 solution chamber, and the lysed C-reactive protein is cleaned with the first cleaning solution to remove the residual lysate on the protein surface.

[0079] After cleaning, the magnetic control component 7 is controlled to move the magnetic bead 5 to the top of the No. 1 solution chamber. Then, the eccentric syringe 3 is controlled to draw the cleaning solution in the No. 1 solution chamber and transfer it to the waste liquid chamber. Then, the eccentric syringe 3 is controlled to draw the antibody in the No. 3 solution chamber and transfer it to the No. 1 solution chamber.

[0080] After the antibody is pipetted, the magnetic control component 7 moves the magnetic bead 5 to the lower middle part of solution compartment 1, so that the washed C-reactive protein reacts with the antibody to form an antigen-antibody conjugate.

[0081] After the reaction is completed, the magnetic control component 7 is controlled to move the magnetic bead 5 to the top of the No. 1 solution chamber. Then, the eccentric syringe 3 is controlled to draw the antibody solution in the No. 1 solution chamber and transfer it to the waste liquid chamber. Then, the eccentric syringe 3 is controlled to draw the second washing liquid in the No. 4 solution chamber and transfer it to the No. 1 solution chamber.

[0082] After the second cleaning solution is pipetted, the magnetic control component 7 is controlled to move the magnetic bead 5 to the lower middle part of the No. 1 solution chamber, and the antigen-antibody conjugate is cleaned with the second cleaning solution to remove the antibodies remaining on the surface of the antigen-antibody conjugate.

[0083] After cleaning, the magnetic control component 7 is controlled to move the magnetic bead 5 to the top of the No. 1 solution chamber. Then, the eccentric injector 3 is controlled to draw the cleaning liquid in the No. 1 solution chamber and transfer it to the waste liquid chamber. Then, the eccentric injector 3 is controlled to draw the luminescent substrate in the No. 5 solution chamber and transfer it to the No. 1 solution chamber.

[0084] After the luminescent substrate is pipetted, the magnetic control component 7 moves the magnetic bead 5 to the lower middle part of solution compartment 1, so that the antigen-antibody conjugate binds to the luminescent substrate for subsequent fluorescence detection.

[0085] After the reaction is completed, the magnetic control component 7 moves the magnetic bead 5 to the top of the No. 1 solution chamber. Then, the eccentric injector 3 draws up the luminescent substrate in the No. 1 solution chamber and transfers it to the waste liquid chamber. Then, the PMT element is used to irradiate the reactant in the sample outlet 6 for fluorescence detection.

[0086] In another specific embodiment, the sample processing module 1 is provided with six solution chambers 11. The five solution chambers 11 contain lysis buffer, first washing buffer, second washing buffer, elution buffer and amplification buffer in sequence. The sample addition channel is connected to the solution chamber 11 containing the lysis buffer. An amplification tube is provided outside the sample outlet 6 at the bottom of the sample processing module 1. The other end of the amplification tube is connected to the sample inlet of the detection module so that the MPPC detection element can perform multiplex fluorescence measurement on the amplified PCR.

[0087] It should be noted that the terms "lysis buffer," "first cleaning solution," and "second cleaning solution" mentioned above are only used to indicate the function of the reagents; the types of lysis buffer, first cleaning solution, and second cleaning solution used may differ in different types of tests, and the specific types of reagents should be determined according to the actual test requirements.

[0088] The above-mentioned sample processing and detection device can perform nucleic acid lysis, washing, elution and drying and amplification on the sample. The amplified reactants are transferred to the amplification tube through the sample outlet 6, and then multiplex fluorescence quantitative detection is performed on them using the MPPC detection element.

[0089] It should be noted that the first and second cleaning solutions mentioned in this application are only used to distinguish the types of reagents and do not contain any limitation on the order.

[0090] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other.

[0091] The sample processing and testing device and sample processing apparatus provided by this utility model have been described in detail above. Specific examples have been used to illustrate the principle and implementation of this utility model. The descriptions of the embodiments above are only for the purpose of helping to understand the method and core idea of ​​this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made to this utility model without departing from the principle of this utility model, and these improvements and modifications also fall within the protection scope of the claims of this utility model.

Claims

1. A sample processing device, characterized by, The application relates to a sample processing device. The sample processing device comprises a sample processing module (1) provided with a sample adding channel and a plurality of solution containers (11), at least one of the solution containers (11) is provided with magnetic beads (5) for adsorbing nucleic acid or protein, the bottom of the solution container (11) is communicated with a sealed pipette channel (12), and the pipette channel (12) is provided with a sealing pad (4). A liquid driving module is installed in the sample processing module (1), and the bottom of the liquid driving module is provided with a syringe needle which can be inserted into the sealing pad (4). At least one of the liquid driving module and the sample processing module (1) is driven to move relatively by a power mechanism, so that the syringe needle of the liquid driving module is inserted into the corresponding pipette channel (12) of different solution containers (11).

2. The sample processing device of claim 1, wherein, The liquid driving module comprises a syringe mounting rack (2) and a syringe, the syringe is sleeved in a syringe mounting hole of the sample processing module (1) through the syringe mounting rack (2), the syringe mounting rack (2) is threadedly connected with the syringe mounting hole, and the syringe is clamped in the syringe mounting rack (2).

3. The sample processing device of claim 2, wherein, The syringe comprises an eccentric syringe (3) in which the syringe needle is arranged eccentrically, the eccentric syringe (3) is arranged at the center of the sample processing module (1), the solution containers (11) and the pipette channels (12) are uniformly distributed along the circumferential direction of the sample processing module (1), and the pipette channels (12) are arranged on the side of the solution containers (11) which is relatively close to the eccentric syringe (3).

4. The sample processing device of claim 3, wherein, The sealing pad (4) for sealing the pipette channels (12) is an annular sealing pad which is integrally arranged, and the annular sealing pad is provided with a downwardly recessed sealing part at the position corresponding to each pipette channel (12).

5. The sample processing device of claim 4, wherein, The bottom of the sample processing module (1) is provided with a limiting groove, and the outer edge of the annular sealing pad is provided with a limiting part for clamping the limiting groove.

6. The sample processing device of claim 3, wherein, The bottom of the sample processing module (1) is provided with a rotary motor, the rotary motor can drive the sample processing module (1) to step relatively to the eccentric syringe (3), and the stepping angle of the rotary motor is the same as the central angle of two adjacent solution containers (11).

7. The sample processing device of any one of claims 1-6, wherein, The top of the solution container (11) is provided with a sealing cover, the sealing cover is provided with a filter element, and the filter element is used for maintaining the balance of the internal and external air pressures of the solution container (11) and preventing liquid from entering the solution container (11).

8. The sample processing device of claim 7, wherein, The sealing cover of each solution container (11) is an integral structure.

9. A sample processing detection device, characterized by, The application further discloses a sample processing device which comprises a sample processing assembly, a magnetic control assembly (7) and a detection module.

10. The sample processing assay device of claim 9, wherein, The magnetic control assembly (7) comprises an electromagnet which is sleeved outside the solution container (11), when the electromagnet is powered, the electromagnet adsorbs the magnetic beads (5) to the top of the solution container (11), so that the magnetic beads (5) are separated from the solution; When the electromagnet is powered off, the magnetic beads (5) are located in the middle or bottom of the solution container (11), so that the magnetic beads (5) are immersed in the solution.

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