Chip heating device compatible with electromagnetic control system

Abstract

The utility model discloses a chip heating device compatible with an electromagnetic control system. The chip heating device comprises a micro-fluidic chip, a substrate, an electromagnetic control chip, a ceramic heating sheet and a base, a micro-fluidic chip groove and a magnet sliding groove are respectively formed in the top end and the bottom end of the substrate. The influence on the magnet is avoided through the copper substrate, and the magnet can do reciprocating motion on a straight line through the magnet chute, so that magnetic beads of a micro-fluidic chip test cavity fixed at the upper part of the substrate are controlled; the heat of the heating ceramic sheet below the micro-fluidic chip is effectively transferred, so that a specific area of the micro-fluidic chip is heated under the condition that the movement of the magnet is not influenced, the problem that heating is needed in nucleic acid detection of an electromagnetic control system is solved, the ceramic heating sheet and the electromagnetic control system are integrated, and the heating efficiency is improved. The situation that a heating piece needs to be additionally arranged in the micro-fluidic chip in advance is avoided, and the situation that the upper portion of the micro-fluidic chip needs to be heated, so that optical detection is affected is also avoided.

Description

Technical Field

[0001] This utility model relates to the field of biosensing and detection technology, specifically to a chip heating device compatible with an electromagnetic control system. Background Technology

[0002] Nucleic acid extraction is a crucial step in molecular biology detection. Traditional nucleic acid extraction methods often involve cumbersome procedures and the use of toxic reagents, which not only limits the throughput and speed of detection but also poses a threat to the health of laboratory personnel. The emergence of magnetic bead-based nucleic acid extraction technology has significantly improved these shortcomings. Compared with traditional nucleic acid extraction, magnetic bead-based nucleic acid extraction has the advantages of high throughput, high degree of automation, and safety.

[0003] Existing bioassay methods based on magnetic bead nucleic acid extraction typically use a displacement stage to manipulate magnets within a microfluidic chip, which is insufficient for portable testing needs. Using a magnetic field generated by an energized coil to control the movement of a magnet and thus the magnetic bead is a more miniaturized method; however, in nucleic acid testing, the magnet obstructs contact between the bottom heating element and the chip, affecting subsequent test results.

[0004] Therefore, it is of great significance to provide a chip heating device that is compatible with electromagnetic control systems to solve the problems existing in the current technology. Utility Model Content

[0005] In view of this, the purpose of this application is to provide a chip heating device compatible with an electromagnetic control system, so as to solve the problem that when facing nucleic acid testing, the magnet obstructs the contact between the bottom heating plate and the chip, thereby affecting the subsequent test results.

[0006] To achieve the above objectives, this utility model provides the following technical solution:

[0007] A chip heating device compatible with an electromagnetic control system includes a microfluidic chip, a substrate, an electromagnetic control chip, a ceramic heating element, and a base;

[0008] The substrate has a microfluidic chip slot and a magnetic slide slot at its top and bottom, respectively. The microfluidic chip is installed inside the microfluidic chip slot. The surface of the base has an electromagnetic control chip slot. A heating element slot is provided on one side of the electromagnetic control chip slot. The ceramic heating element is installed inside the heating element slot. The electromagnetic control chip is installed inside the electromagnetic control chip slot. The surface of the base has four fixing holes. The four corners of the substrate have screw holes. The screw holes and fixing holes are fixedly connected by screws. The substrate is located above the electromagnetic control chip.

[0009] Preferably, the surface of the substrate is provided with a heat insulation groove, which extends through the upper and lower surfaces of the substrate.

[0010] Preferably, a magnet is slidably connected inside the magnet groove, and the diameter and height of the magnet groove are the same as those of the magnet.

[0011] Preferably, the top of the microfluidic chip has multiple test cavities arranged in a straight line.

[0012] Preferably, the ceramic heating element is located directly below the rightmost test chamber.

[0013] Preferably, the substrate is made of copper and the base is made of aluminum.

[0014] Preferably, a connecting slot is provided on the side of the electromagnetic control chip slot, and the connecting slot is used for the ribbon cable connection of the electromagnetic control chip.

[0015] Compared with the prior art, the beneficial effects of this utility model are:

[0016] This invention avoids the influence of the magnet by using a copper substrate. The bottom of the substrate has a magnet groove with the same diameter and height as the magnet, which allows the magnet to move repeatedly in a straight line, thereby controlling the magnetic beads in the microfluidic chip test cavity fixed on the upper part of the substrate. At the same time, the substrate still has a certain continuous thin layer below the area of ​​the microfluidic chip that needs to be heated, which can effectively transfer heat from the heating ceramic sheet below the microfluidic chip. This allows heating of a specific area of ​​the microfluidic chip without affecting the movement of the magnet. This invention solves the problem of heating required in nucleic acid detection of electromagnetic control systems. The ceramic heating sheet is integrated with the electromagnetic control system, avoiding the need for an additional pre-placed heating sheet in the microfluidic chip and avoiding heating on the upper part of the microfluidic chip, which would affect optical detection.

[0017] The above description is only an overview of the technical solution of this application. In order to better understand the technical means of this application and implement it in accordance with the contents of the specification, and to make the above and other objects, features and advantages of this application more obvious and understandable, the preferred embodiments of this application are described in detail below with reference to the accompanying drawings.

[0018] The above and other objects, advantages and features of this application will become more apparent to those skilled in the art from the following detailed description of specific embodiments in conjunction with the accompanying drawings. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. In all drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0020] Figure 1 This is a schematic diagram of the structure of this utility model;

[0021] Figure 2 This is a schematic diagram of the substrate structure in this utility model;

[0022] Figure 3 This is a schematic diagram of the base structure in this utility model.

[0023] In the figure: 1. Microfluidic chip; 2. Substrate; 3. Electromagnetic control chip; 4. Ceramic heating element; 5. Base; 6. Screw hole; 7. Fixing hole; 8. Microfluidic chip slot; 9. Magnet groove; 10. Magnet; 11. Electromagnetic control chip slot; 12. Heating element slot. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. In the following description, specific details such as specific configurations and components are provided merely to help fully understand the embodiments of this application. Therefore, those skilled in the art should understand that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of this application. In addition, for clarity and brevity, descriptions of known functions and structures are omitted in the embodiments.

[0025] Furthermore, reference numerals and / or letters may be repeated in different examples within this application. Such repetition is for the purpose of simplification and clarity and does not in itself indicate a relationship between the various embodiments and / or settings discussed.

[0026] In this article, the term "and / or" is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can mean: A exists alone, B exists alone, and A and B exist simultaneously. The term " / and" in this article describes another type of relationship between related objects, indicating that two relationships can exist. For example, A / and B can mean: A exists alone, and A and B exist alone. In addition, the character " / " in this article generally indicates that the related objects before and after it are in an "or" relationship.

[0027] It should also be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion.

[0028] Please see Figure 1-3 This utility model provides a technical solution for a chip heating device compatible with an electromagnetic control system: including a microfluidic chip 1, a substrate 2, an electromagnetic control chip 3, a ceramic heating element 4, and a base 5;

[0029] The top and bottom of the substrate 2 are respectively provided with microfluidic chip grooves 8 and magnetic slide grooves 9. Microfluidic chip 1 is installed inside the microfluidic chip groove 8. The surface of the base 5 is provided with electromagnetic control chip grooves 11. A heating plate groove 12 is provided on one side of the electromagnetic control chip groove 11. Ceramic heating plate 4 is installed inside the heating plate groove 12. Electromagnetic control chip 3 is installed inside the electromagnetic control chip groove 11. The surface of the base 5 is provided with four fixing holes 7. Screw holes 6 are provided at the four corners of the substrate 2. The screw holes 6 and fixing holes 7 are fixedly connected by screws. The substrate 2 is located above the electromagnetic control chip 3.

[0030] A heat insulation groove is formed on the surface of the substrate 2, which runs through the upper and lower surfaces of the substrate 2 to prevent heat from being transferred to the non-heating areas of the microfluidic chip 1.

[0031] Magnet 10 is slidably connected inside the magnet groove 9. The diameter and height of the magnet groove 9 are the same as those of the magnet 10. Multiple test chambers are opened at the top of the microfluidic chip 1. The test chambers are arranged in a straight line. The magnet groove 9 allows the magnet 10 to move repeatedly in a straight line, thereby controlling the magnetic beads in the test chambers of the microfluidic chip 1 fixed on the upper part of the substrate 2.

[0032] The ceramic heating element 4 is located directly below the rightmost test chamber, and heat is effectively transferred to the ceramic heating element 4 below the microfluidic chip 1.

[0033] The substrate 2 is made of copper, which avoids affecting the magnet 10. The base 5 is made of aluminum.

[0034] A connecting slot is provided on the side of the electromagnetic control chip slot 11, which is used for the ribbon cable connection of the electromagnetic control chip 3.

[0035] In practical use, the copper substrate 2 avoids the influence on the magnet. The bottom of the substrate 2 is provided with a magnet groove 9 that is consistent with the diameter and height of the magnet 10. The magnet groove 9 allows the magnet 10 to move repeatedly in a straight line, thereby controlling the magnetic beads in the test cavity of the microfluidic chip 1 fixed on the upper part of the substrate 2. At the same time, the substrate 2 still has a certain continuous thin layer below the area of ​​the microfluidic chip 1 that needs to be heated, which can effectively transfer the heat of the heating ceramic sheet 4 below the microfluidic chip 1. Thus, the specific area of ​​the microfluidic chip 1 can be heated without affecting the movement of the magnet. This utility model solves the problem of heating required in nucleic acid detection of electromagnetic control system. The ceramic heating sheet 4 is integrated with the electromagnetic control system, avoiding the need to pre-place an additional heating sheet in the microfluidic chip 1, and also avoiding the need to heat the upper part of the microfluidic chip, which would affect the optical detection.

[0036] The above description is merely a preferred embodiment of this utility model and does not limit the scope of protection of this utility model. For those skilled in the art, this utility model can have various modifications and variations. Any changes, modifications, substitutions, integrations, and parameter alterations made to these embodiments within the spirit and principles of this utility model, through conventional substitutions or methods that achieve the same function without departing from the principles and spirit of this utility model, fall within the scope of protection of this utility model.

Claims

1. A chip heating device compatible with an electromagnetic control system, characterized in that: It includes a microfluidic chip (1), a substrate (2), an electromagnetic control chip (3), a ceramic heating element (4), and a base (5); The substrate (2) has a microfluidic chip groove (8) and a magnet groove (9) at its top and bottom, respectively. The microfluidic chip (1) is installed inside the microfluidic chip groove (8). The base (5) has an electromagnetic control chip groove (11) on its surface. A heating plate groove (12) is provided on one side of the electromagnetic control chip groove (11). The ceramic heating plate (4) is installed inside the heating plate groove (12). The electromagnetic control chip (3) is installed inside the electromagnetic control chip groove (11). The base (5) has four fixing holes (7) on its surface. The four corners of the substrate (2) have screw holes (6). The screw holes (6) and the fixing holes (7) are fixedly connected by screws. The substrate (2) is located above the electromagnetic control chip (3).

2. The chip heating device compatible with an electromagnetic control system as described in claim 1, characterized in that: The substrate (2) has a heat insulation groove on its surface, and the heat insulation groove extends through the upper and lower surfaces of the substrate (2).

3. The chip heating device compatible with an electromagnetic control system as described in claim 1, characterized in that: A magnet (10) is slidably connected inside the magnet groove (9), and the diameter and height of the magnet groove (9) are the same as those of the magnet (10).

4. The chip heating device compatible with an electromagnetic control system as described in claim 1, characterized in that: The top of the microfluidic chip (1) has multiple test cavities arranged in a straight line.

5. A chip heating device compatible with an electromagnetic control system as described in claim 1, characterized in that: The ceramic heating element (4) is located directly below the rightmost test chamber.

6. A chip heating device compatible with an electromagnetic control system as described in claim 1, characterized in that: The substrate (2) is made of copper, and the base (5) is made of aluminum.

7. A chip heating device compatible with an electromagnetic control system as described in claim 1, characterized in that: The electromagnetic control chip slot (11) has a connecting slot on its side, which is used for the wiring connection of the electromagnetic control chip (3).

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