Extraction device for sensitization antigen preparation

Abstract

The utility model relates to the technical field of sensitization antigen preparation, in particular to an extraction device for sensitization antigen preparation, which comprises a mounting plate, a first support plate is fixedly mounted in the middle of one side of the mounting plate, a driving mechanism is mounted on the outer side of the first support plate, and an adjusting mechanism is mounted at the bottom end of the driving mechanism. A liquid suction pipe mounting mechanism is mounted at the bottom end of the adjusting mechanism, and an extraction mechanism is mounted at the top end of the mounting plate. The utility model has the beneficial effects that the rotating column can be rotated to drive the pipette to lift and move stably and accurately, and the pipette is stably inserted into a cell suspension with a specified depth to extract antigens, so that the shaking of the cell suspension cannot be caused; the heights of the bottom ends of the pipettes are different, so that the pipettes can move downwards along with the mounting rack at the same time and are inserted into the cell suspension at different depths, and a plurality of antigens at different depths in the cell suspension are extracted at the same time through the pipette pump.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of sensitized antigen preparation, especially to an extraction device for sensitized antigen preparation. BACKGROUND

[0002] Cell therapy refers to a treatment method that applies autologous, allogeneic or xenogeneic (non-human) somatic cells of human beings, which are retransplanted (or implanted) into human bodies after in-vitro operation. Such in-vitro operation includes cell passage, expansion, screening and treatment of drugs or other treatments that can change the biological behavior of cells in-vitro. The somatic cells after in-vitro operation can be used for the treatment of diseases, and also can be used for the diagnosis and prevention of diseases. Somatic cell therapy has various types, including in-vivo retransplantation of in-vitro activated single nucleated cells such as lymphokine activated killer cells (LAK), tumor infiltrative lymphocytes (TIL), monocytes, macrophages or in-vitro sensitized killer cells (IVS) and the like. Domestic immune cell therapy is more applied to the treatment of tumors and viral infectious diseases such as hepatitis and AIDS. At present, the mature autologous immune cell therapy technology applied in the clinic is one of the important methods for tumor biological treatment. Under the action of various immune active factors, the immune active cells (single nucleated cells) separated from autologous peripheral blood are effectively activated and expanded, and then retransplanted into the patient's body to directly kill or induce immune effector cells to kill tumor cells or virus infected cells, or to regulate and enhance the immune function of the body. The autologous immune cell therapy technology includes cytokine induced killer cell (CIK) immunotherapy, dendritic cell (DC) immunotherapy, DC-CIK cell immunotherapy, nature killer (NK) immunotherapy and the like.

[0003] Antigen refers to a substance that can induce an immune response. Under the stimulation of antigenic substances, the body produces immunoglobulin that has specific binding reaction with corresponding antigens, which is called antibody. Antigen and antibody are used as reagents for in-vitro diagnosis, drugs for treating diseases, ligands for immune affinity chromatography and the like. They have wide application in the fields of life science research, biotechnology and medicine. Especially, antibody as the core reagent of various immune analysis plays a crucial role in the sensitivity and specificity of immune analysis results. Preparation of high specificity and high titer antibody is the basis of immunology technology.

[0004] Antibody products are mainly derived from the plasma components of donors and various animals or animal cell culture supernatants and other biological raw materials. In the process of preparing antibodies, the components in the biological raw materials need to be separated to obtain antibodies with single components and high purity.

[0005] Therefore, an extraction device for preparing sensitized antigens is provided.

[0006] The existing extraction device for preparing sensitized antigens is inconvenient to stably insert the pipette into a specified depth when aspirating cell suspensions with different depths, and the pipette is easily shaken to cause mixing of the cell suspensions, affecting the accurate extraction of antigens. In addition, only a single pipette is used to extract antigens, and multiple pipettes cannot be used to extract multiple antigen samples at one time. Content of the utility model

[0007] The utility model aims at solving the problem that the pipette is inconvenient to stably insert into a specified depth when aspirating cell suspensions with different depths, and the pipette is easily shaken to cause mixing of the cell suspensions, affecting the accurate extraction of antigens in the prior art, and provides an extraction device for preparing sensitized antigens.

[0008] To achieve the above-mentioned purpose, the utility model provides the following technical scheme:

[0009] The utility model designs a kind of sensitizing antigen preparation with extraction device, including mounting plate, first support plate is fixedly installed in the middle of one side of mounting plate, drive mechanism is installed on the outside of first support plate, adjusting mechanism is installed at the bottom of drive mechanism, suction tube installation mechanism is installed at the bottom of adjusting mechanism, extraction mechanism is installed at the top of mounting plate;The drive mechanism includes rotary plate, first drive plate, second drive plate and third drive plate, the top of first support plate is rotated and passes through rotary column, rotary plate is fixed at the outer end of rotary column, the bottom of first drive plate is hingedly connected between the top of first drive plate and rotary plate, one end of second drive plate is hingedly connected between the bottom of first drive plate, the outside of first support plate is fixed with support column in the middle, the middle of second drive plate is hingedly connected between the outer end of support column, the other end of second drive plate is hingedly connected with the top of third drive plate, the bottom of third drive plate is hingedly connected with lifting column, the bottom end of second support plate is fixed with second support plate on the outside of first support plate, first guide hole is opened in the surface of second support plate in the middle, guide cylinder is fixed at the bottom of second support plate and located the position of the bottom of first guide hole, lifting column slides through first guide hole and guide cylinder;The adjusting mechanism includes adjusting rod, adjusting slot is opened in the middle of lifting column, adjusting rod is screwed into adjusting slot, first nut is connected on the surface of adjusting rod and located the position of the bottom of adjusting slot;The suction tube installation mechanism includes mounting frame, moving frame and clamping mechanism, mounting frame is fixed at the bottom of adjusting rod, moving groove is opened in the surface of mounting frame, moving frame is slidably installed in the inside of moving groove, clamping mechanism is installed at both ends of moving frame;The extraction mechanism includes liquid suction pump, liquid guide pipe and suction tube, liquid suction pump is installed at the top of mounting plate, liquid outlet pipe is connected on one side thereof, liquid guide pipe is connected on the other side thereof, the bottom of liquid guide pipe is connected with the top of suction tube, and suction tube passes through moving frame.

[0010] Further, the top of first support plate is provided with a rotating hole, the rotating column rotates through the rotating hole, the surface of rotating column and located on one side of rotating hole is fixed with a limit ring, the surface of rotating column and located on the other side of rotating hole is screwed with a second nut, the side of first support plate and located around the second nut is fixed with a circumferential angle disc, the circumferential angle disc is a circular ring structure, one end of rotating column and located outside the circumferential angle disc is fixed with a knob, the surface of rotating column and close to the knob is an external thread surface structure.

[0011] Further, the mounting frame is a cross structure, both sides of the moving groove are provided with limiting grooves, both sides of the moving frame are fixed with clamping blocks, outer ends of the clamping blocks are fixed with connecting rods, the clamping blocks are slidably inserted into the limiting grooves, and the connecting rods are slidably inserted into the limiting grooves and are connected with third nuts.

[0012] Further, the clamping mechanism comprises a guide rod and a clamping plate, upper and lower positions of both ends of the moving frame are provided with second guide holes, the guide rod is slidably inserted into the second guide holes, a surface of the guide rod and a position outside the second guide holes are connected with a fourth nut, the clamping plate is fixed at an inner end of the guide rod, a spring is slidably sleeved on a surface of the guide rod and a position between the clamping plate and the second guide holes, and the clamping plate clamps both sides of the pipette.

[0013] Further, the mounting plate is a rectangular plate structure and is horizontally arranged, the first supporting plate is a rectangular plate structure and is vertically arranged, the rotating column is a cylindrical structure and is horizontally arranged, the rotating plate is a rectangular plate structure and is arranged in parallel outside the first supporting plate, the first driving plate, the second driving plate and the third driving plate are all rectangular plate structures, and the first driving plate and the third driving plate are both arranged in an inclined manner and are arranged in parallel with each other.

[0014] Further, a hinge column is hingedly connected between the bottom end of the third driving plate and the top end of the lifting column, the second driving plate is rotatably arranged outside the first supporting plate through the supporting column, the supporting column is horizontally arranged and located directly below the rotating column, the lifting column is a cylindrical structure and is vertically arranged, the second supporting plate is a rectangular plate structure and is horizontally arranged directly below the supporting column, and the guide cylinder is a cylindrical structure and is vertically arranged.

[0015] Further, the adjusting groove is a threaded groove structure, the adjusting rod is a threaded rod structure and is vertically arranged and is threadedly connected with each other, the mounting frame is horizontally arranged, the moving frame is a rectangular frame structure and is vertically arranged, the liquid guide pipe is a telescopic flexible pipe structure, and the pipette is a cylindrical structure and is vertically arranged.

[0016] Further, the limiting groove is a long strip structure and is horizontally arranged, the clamping block is a rectangular block structure and is slidably clamped in the limiting groove, the connecting rod is a threaded rod structure and is horizontally arranged, the guide rod is a threaded rod structure and is horizontally arranged, the clamping plate is a circular plate structure and is vertically arranged, and the spring is located in the moving frame.

[0017] The utility model provides a kind of extraction device for preparation of sensitized antigen, and beneficial effect is in that:

[0018] 1. The utility model discloses a first support plate and second support plate are installed on the top of mounting plate, when extracting antigen through the pipette, the rotating column is rotated through the stirring lever, and the angle of rotation is observed through the circumferential angle disc, the first drive plate is moved to drive the second drive plate to rotate around the support column, and the third drive plate is moved to drive the lifting column to move up and down through the bottom of third drive plate, so that the mounting frame is moved up and down through the adjusting lever, and the pipette is clamped and installed on the mounting frame, the height of mounting frame can be adjusted by rotating the adjusting lever, so that the pipette can be moved up and down stably and accurately by rotating the rotating column, and stably inserted into the cell suspension of specified depth to extract antigen, and the cell suspension is not shaken.

[0019] 2. The utility model discloses a moving frame is arranged in the mounting frame and is slid, and the pipette passes through the moving frame and is clamped and installed through the clamping mechanism, so that one to four pipettes can pass through the surface of mounting frame, and the pipette is clamped and installed on the protruding end of mounting frame through the spring elastic clamping plate, and the different clamping height of pipette can be adjusted, so that the height of the bottom end of pipette is different, can move down simultaneously with mounting frame, and is inserted into the different depth of cell suspension, and the antigen of multiple different depths in cell suspension is extracted simultaneously through the pipette pump. DRAWINGS

[0020] Figure 1 It is the whole structure schematic diagram of the utility model;

[0021] Figure 2 It is the bottom view of the utility model; Figure 1

[0022] Figure 3 It is the rotating column part schematic diagram of the utility model; Figure 1

[0023] Figure 4 It is the drive mechanism schematic diagram of the utility model; Figure 1

[0024] Figure 5 It is the first support plate and second support plate part schematic diagram of the utility model; Figure 1

[0025] Figure 6 It is the adjusting lever and mounting frame part schematic diagram of the utility model; Figure 1

[0026] Figure 7 It is the moving frame and clamping mechanism schematic diagram of the utility model. Figure 1

[0027] ​​​​​​In the figure: 1, mounting plate; 2, liquid suction pump; 3, liquid outlet pipe; 4, first support plate; 5, second drive plate; 6, first drive plate; 7, support column; 8, rotating plate; 9, rotating column; 10, third drive plate; 11, hinged column; 12, lifting column; 13, second support plate; 14, guide cylinder; 15, liquid guide pipe; 16, first nut; 17, adjusting rod; 18, mounting frame; 19, liquid suction pipe; 20, moving frame; 21, moving groove; 22, circumferential angle disc; 23, second nut; 24, dialing rod; 25, limiting ring; 26, adjusting groove; 27, rotating hole; 28, first guide hole; 29, limiting groove; 30, connecting rod; 31, third nut; 32, clamping block; 33, second guide hole; 34, fourth nut; 35, guide rod; 36, clamping plate; 37, spring. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments.

[0029] Embodiment, please refer to Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 and Figure 7 , one of the sensitized antigen preparation extraction device is shown in the figure, including mounting plate 1, one side of the mounting plate 1 is fixedly installed with first support plate 4, the outer side of the first support plate 4 is installed with drive mechanism, the bottom end of the drive mechanism is installed with adjusting mechanism, the bottom end of the adjusting mechanism is installed with liquid suction pipe mounting mechanism, the top end of the mounting plate 1 is installed with extraction mechanism.

[0030] In detail, the drive mechanism includes rotating plate 8, first drive plate 6, second drive plate 5 and third drive plate 10, the top end of the first support plate 4 is rotatably through rotating column 9, the rotating plate 8 is fixed at the outer end of the rotating column 9, the top end of the first drive plate 6 is hingedly connected with the bottom end of the rotating plate 8, one end of the second drive plate 5 is hingedly connected with the bottom end of the first drive plate 6, the outer side of the first support plate 4 is fixedly provided with support column 7, the outer end of the support column 7 is hingedly connected with the middle of the second drive plate 5, the top end of the third drive plate 10 is hingedly connected with the other end of the second drive plate 5.

[0031] The bottom end of the third driving plate 10 is hingedly connected with a lifting column 12, the outer bottom end of the first supporting plate 4 is fixed with a second supporting plate 13, a first guide hole 28 is opened in the middle of the surface of the second supporting plate 13, a guide cylinder 14 is fixed at the bottom end of the second supporting plate 13 and at the position of the bottom end of the first guide hole 28, and the lifting column 12 slides through the first guide hole 28 and the guide cylinder 14.

[0032] A rotating hole 27 is opened at the top end of the first supporting plate 4, the rotating column 9 rotates through the rotating hole 27, a limiting ring 25 is fixed at the surface of the rotating column 9 and at the position of one side of the rotating hole 27, a second nut 23 is threadedly connected at the surface of the rotating column 9 and at the position of the other side of the rotating hole 27, a circumferential angle disc 22 is fixed at the side of the first supporting plate 4 and at the position around the second nut 23, the circumferential angle disc 22 is a circular ring structure, a pushing rod 24 is fixed at one end of the rotating column 9 and at the position outside the circumferential angle disc 22, and the surface of the rotating column 9 and the position close to the pushing rod 24 is an external thread surface structure.

[0033] The mounting plate 1 is a rectangular plate structure and is horizontally arranged, the first supporting plate 4 is a rectangular plate structure and is vertically arranged, the rotating column 9 is a cylindrical structure and is horizontally arranged, the rotating plate 8 is a rectangular plate structure and is arranged in parallel outside the first supporting plate 4, the first driving plate 6, the second driving plate 5 and the third driving plate 10 are all rectangular plate structures, the first driving plate 6 and the third driving plate 10 are both arranged obliquely and in parallel with each other.

[0034] A hinge column 11 is hingedly connected between the bottom end of the third driving plate 10 and the top end of the lifting column 12, the second driving plate 5 is rotatably mounted outside the first supporting plate 4 through the supporting column 7, the supporting column 7 is horizontally arranged and is located directly below the rotating column 9, the lifting column 12 is a cylindrical structure and is vertically arranged, the second supporting plate 13 is a rectangular plate structure and is horizontally arranged directly below the supporting column 7, and the guide cylinder 14 is a cylindrical structure and is vertically arranged.

[0035] Further, the adjusting mechanism comprises an adjusting rod 17, an adjusting groove 26 is opened in the middle of the lifting column 12, the adjusting rod 17 is threadedly inserted into the adjusting groove 26, and a first nut 16 is connected at the surface of the adjusting rod 17 and at the position of the bottom end of the adjusting groove 26.

[0036] The adjusting groove 26 is a thread groove structure, the adjusting rod 17 is a threaded rod structure and is vertically arranged and threadedly connected with each other.

[0037] In detail, the pipette mounting mechanism comprises a mounting frame 18 fixed to the bottom end of the adjusting rod 17, a moving frame 20 slidingly installed in the moving slot 21 on the surface of the mounting frame 18, and a clamping mechanism installed at both ends of the moving frame 20.

[0038] The mounting frame 18 is in a cross-shaped structure, both sides of the moving slot 21 are provided with limiting slots 29, both sides of the moving frame 20 are fixed with clamping blocks 32, the outer end of the clamping block 32 is fixed with a connecting rod 30, the clamping block 32 is slidingly inserted into the limiting slot 29, and the connecting rod 30 is slidingly inserted through the limiting slot 29, and the third nut 31 is connected to the surface of the connecting rod 30 outside the limiting slot 29.

[0039] The mounting frame 18 is horizontally arranged, the moving frame 20 is in a rectangular frame structure and vertically arranged, the liquid guide pipe 15 is in a telescopic flexible pipe structure, and the pipette 19 is in a circular pipe structure and vertically arranged.

[0040] The first support plate 4 and the second support plate 13 are installed at the top end of the mounting plate 1, when the antigen is extracted by the pipette 19, the rotating column 9 is rotated by the dialing rod 24, the rotating angle is observed by the circumferential angle disc 22, the first driving plate 6 is driven to move by the rotating plate 8, the second driving plate 5 is rotated around the support column 7, the third driving plate 10 is driven to move, the lifting column 12 is driven to move up and down by the bottom end of the third driving plate 10, the mounting frame 18 is driven to move up and down by the adjusting rod 17, and the pipette 19 is clamped and mounted on the mounting frame 18, the height of the mounting frame 18 can be adjusted by rotating the adjusting rod 17, the pipette 19 can be stably and accurately lifted and moved by rotating the rotating column 9, the pipette 19 can be stably inserted into the cell suspension at a specified depth to extract the antigen, and the cell suspension will not be shaken.

[0041] The clamping mechanism comprises a guide rod 35 and a clamping plate 36, the upper and lower positions of both ends of the moving frame 20 are provided with second guide holes 33, the guide rod 35 is slidingly inserted through the second guide holes 33, the fourth nut 34 is connected to the surface of the guide rod 35 outside the second guide holes 33, the clamping plate 36 is fixed to the inner end of the guide rod 35, the spring 37 is slidingly sleeved on the surface of the guide rod 35 between the clamping plate 36 and the second guide holes 33, and the clamping plate 36 is clamped on both sides of the pipette 19.

[0042] The limiting groove 29 is long strip structure and is horizontally arranged, the clamping block 32 is rectangular block structure and is clamped and slides in the inside of the limiting groove 29, the connecting rod 30 is screw rod structure and is horizontally arranged, the guide rod 35 is screw rod structure and is horizontally arranged, the clamping plate 36 is circular plate structure and is vertically arranged, and the spring 37 is located in the inside of the moving frame 20.

[0043] The moving frame 20 is slidably arranged in the mounting rack 18, and the pipette 19 passes through the moving frame 20 and is clamped and mounted by the clamping mechanism. Thus, one to four pipettes 19 can pass through the surface of the mounting rack 18, and the pipette 19 is clamped and mounted on the extending end of the mounting rack 18 by the spring 37 and the clamping plate 36. The spacing between the one to four pipettes 19 can be adjusted by moving the moving frame 20 along the limiting groove 29, the mutual influence during antigen extraction is reduced, and the clamping height of the pipette 19 can be adjusted. The bottom end of the pipette 19 has different heights, and can be moved downward together with the mounting rack 18 and inserted into the cell suspension at different depths, and the antigens at multiple different depths in the cell suspension are extracted by the suction pump 2.

[0044] Further, the extraction mechanism includes the suction pump 2, the liquid guide pipe 15 and the pipette 19. The suction pump 2 is mounted at the top end of the mounting plate 1, one side of which is connected with the liquid outlet pipe 3, and the other side is connected with the liquid guide pipe 15. The bottom end of the liquid guide pipe 15 is connected with the top end of the pipette 19, and the pipette 19 passes through the moving frame 20.

[0045] Working mode: the first support plate 4 and the second support plate 13 are mounted at the top end of the mounting plate 1. When the pipette 19 extracts antigens, the rotating column 9 is rotated by the rotating lever 24, and the rotating angle is observed by the circumferential angle disc 22. The first driving plate 6 is driven to move, thereby driving the second driving plate 5 to rotate around the support column 7, and then driving the third driving plate 10 to move. The lifting column 12 is driven to move up and down by the bottom end of the third driving plate 10, thereby driving the mounting rack 18 to move up and down by the adjusting lever 17. The pipette 19 is clamped and mounted on the mounting rack 18. The height of the mounting rack 18 can be adjusted by rotating the adjusting lever 17. Thus, the pipette 19 is stably and accurately lifted and moved by rotating the rotating column 9, and is stably inserted into the cell suspension at a specified depth to extract antigens, without causing the cell suspension to shake.

[0046] The mobile frame 20 is slidably arranged in the mounting frame 18, and the pipettes 19 pass through the mobile frame 20 and are clamped and mounted by the clamping mechanism, so that one to four pipettes 19 can pass through the surface of the mounting frame 18, the pipettes 19 are clamped and mounted at the extending end of the mounting frame 18 by the spring 37 and the clamping plate 36, the spacing between the one to four pipettes 19 can be adjusted by moving the mobile frame 20 along the limiting groove 29, the mutual influence during the antigen extraction is reduced, the different clamping heights of the pipettes 19 can be adjusted, the bottom end of the pipette 19 is at different heights, the pipette 19 can be simultaneously moved downward with the mounting frame 18 and inserted into the cell suspension at different depths, and the antigens at multiple different depths in the cell suspension can be simultaneously extracted by the pipette pump 2.

[0047] The above merely describes the preferred specific embodiments of the present application, but the protection scope of the present application is not limited to this. Any person skilled in the art, according to the technical scheme and the inventive concept of the present application, can make equivalent replacement or change within the technical range disclosed by the present application, which should be covered within the protection scope of the present application.

Claims

1. An extraction device for the preparation of an allergenic antigen comprising a mounting plate (1), characterized in that: The middle of one side of the mounting plate (1) is fixedly provided with a first support plate (4), the outer side of the first support plate (4) is provided with a driving mechanism, the bottom end of the driving mechanism is provided with an adjusting mechanism, the bottom end of the adjusting mechanism is provided with a liquid suction tube mounting mechanism, and the top end of the mounting plate (1) is provided with an extraction mechanism. The driving mechanism comprises a rotating plate (8), a first driving plate (6), a second driving plate (5) and a third driving plate (10), the top end of the first support plate (4) is rotatably provided through a rotating column (9), the rotating plate (8) is fixed to the outer end of the rotating column (9), the top end of the first driving plate (6) is hingedly connected with the bottom end of the rotating plate (8), one end of the second driving plate (5) is hingedly connected with the bottom end of the first driving plate (6), the outer side of the first support plate (4) is fixedly provided with a supporting column (7), the outer end of the supporting column (7) is hingedly connected with the middle of the second driving plate (5), the top end of the third driving plate (10) is hingedly connected with the other end of the second driving plate (5), the bottom end of the third driving plate (10) is hingedly connected with a lifting column (12), the outer side bottom end of the first support plate (4) is fixedly provided with a second support plate (13), the surface of the second support plate (13) is provided with a first guide hole (28) in the middle, the bottom end of the second support plate (13) is fixedly provided with a guide cylinder (14) at the position of the bottom end of the first guide hole (28), and the lifting column (12) is slidably provided through the first guide hole (28) and the guide cylinder (14). The adjusting mechanism comprises an adjusting rod (17), the middle of the lifting column (12) is provided with an adjusting groove (26), the adjusting rod (17) is threadedly inserted into the adjusting groove (26), and the surface of the adjusting rod (17) is connected with a first nut (16) at the position of the bottom end of the adjusting groove (26). The liquid suction tube mounting mechanism comprises a mounting frame (18), a moving frame (20) and a clamping mechanism, the mounting frame (18) is fixed to the bottom end of the adjusting rod (17), the surface of the mounting frame (18) is provided with a moving groove (21), the moving frame (20) is slidably arranged in the interior of the moving groove (21), and the clamping mechanism is arranged at both ends of the moving frame (20). The extraction mechanism comprises a liquid suction pump (2), a liquid guide pipe (15) and a liquid suction tube (19), the liquid suction pump (2) is arranged at the top end of the mounting plate (1), one side of the liquid suction pump (2) is connected with a liquid outlet pipe (3), the other side of the liquid suction pump (2) is connected with the liquid guide pipe (15), the bottom end of the liquid guide pipe (15) is connected with the top end of the liquid suction tube (19), and the liquid suction tube (19) passes through the moving frame (20).

2. The device for preparing an allergen extract according to claim 1, characterized in that The top end of the first support plate (4) is provided with a rotating hole (27), the rotating column (9) rotates through the rotating hole (27), the surface of the rotating column (9) and the position on one side of the rotating hole (27) are fixedly connected with a limiting ring (25), the surface of the rotating column (9) and the position on the other side of the rotating hole (27) are threadedly connected with a second nut (23), the side of the first support plate (4) and the position around the second nut (23) are fixedly connected with a circumferential angle disc (22), the circumferential angle disc (22) is a circular ring structure, one end of the rotating column (9) and the position outside the circumferential angle disc (22) are fixedly connected with a pushing rod (24), and the surface of the rotating column (9) and the position close to the pushing rod (24) are an external thread surface structure.

3. The device for preparing an allergen extract according to claim 1, characterized in that: The mounting frame (18) is a cross structure, the two sides of the moving groove (21) are provided with limiting grooves (29), the two sides of the moving frame (20) are fixedly connected with clamping blocks (32), the outer end of the clamping block (32) is fixedly connected with a connecting rod (30), the clamping block (32) is slidingly inserted into the limiting groove (29), the connecting rod (30) slidingly passes through the limiting groove (29), and the surface of the connecting rod (30) and the position outside the limiting groove (29) are connected with a third nut (31).

4. The device for preparing an allergen extract according to claim 3, characterized in that: The clamping mechanism comprises a guide rod (35) and a clamping plate (36), the upper and lower positions of the two ends of the moving frame (20) are provided with second guide holes (33), the guide rod (35) slidingly passes through the second guide hole (33), the surface of the guide rod (35) and the position outside the second guide hole (33) are connected with a fourth nut (34), the clamping plate (36) is fixed to the inner end of the guide rod (35), the surface of the guide rod (35) and the position between the clamping plate (36) and the second guide hole (33) are slidingly sleeved with a spring (37), and the clamping plate (36) clamps the two sides of the pipette (19).

5. The device for preparing an allergen extract according to claim 1, characterized in that: The mounting plate (1) is a rectangular plate structure and is horizontally arranged, the first support plate (4) is a rectangular plate structure and is vertically arranged, the rotating column (9) is a cylindrical structure and is horizontally arranged, the rotating plate (8) is a rectangular plate structure and is arranged in parallel outside the first support plate (4), the first driving plate (6), the second driving plate (5) and the third driving plate (10) are all rectangular plate structures, and the first driving plate (6) and the third driving plate (10) are both arranged in an inclined manner and are arranged in parallel with each other.

6. The device for preparing an allergen extract according to claim 1, characterized in that: The hinge column (11) is hingedly connected between the bottom end of the third driving plate (10) and the top end of the lifting column (12), the second driving plate (5) is rotatably installed on the outer side of the first supporting plate (4) through the supporting column (7), the supporting column (7) is horizontally arranged and located directly below the rotating column (9), the lifting column (12) is in a cylindrical structure and vertically arranged, the second supporting plate (13) is in a rectangular plate structure and horizontally arranged directly below the supporting column (7), and the guide cylinder (14) is in a cylindrical structure and vertically arranged.

7. The device for preparing an allergen extract according to claim 1, characterized in that: The adjusting groove (26) is in a threaded groove structure, the adjusting rod (17) is in a threaded rod structure and vertically arranged and threadedly connected with each other, the mounting frame (18) is horizontally arranged, the moving frame (20) is in a rectangular frame structure and vertically arranged, the liquid guide pipe (15) is in a telescopic flexible pipe structure, and the liquid suction pipe (19) is in a circular pipe structure and vertically arranged.

8. The device for preparing an allergen extract according to claim 4, characterized in that: The limiting groove (29) is in a long strip structure and horizontally arranged, the clamping block (32) is in a rectangular block structure and clamped and slid in the limiting groove (29), the connecting rod (30) is in a threaded rod structure and horizontally arranged, the guide rod (35) is in a threaded rod structure and horizontally arranged, the clamping plate (36) is in a circular plate structure and vertically arranged, and the spring (37) is located in the moving frame (20).

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