DC cell vaccine split charging and storing device
By designing storage bags and feed tubes, and using adapter sealing joints and flow-blocking clamps, the problems of uneven dispensing and low production efficiency of DC cell vaccines were solved, achieving efficient dispensing, storage, and cryopreservation, thus ensuring cell viability.
Patent Information
- Application Number
- CN202423310148.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-31
- Publication Date
- 2026-01-27
- Estimated Expiration
- 2034-12-31
AI Technical Summary
DC cell vaccines are prone to sinking during the packaging process, resulting in uneven distribution. They are also susceptible to cell damage during room temperature operations and have low production efficiency. Existing technologies make it difficult to efficiently package and cryopreserve large quantities of these vaccines.
Several storage pouches arranged in a straight line are connected by a feed tube. They are then connected to an external syringe for rapid dispensing using a connecting sealing connector. Combined with flow-blocking clamps and heat-sealing with indicators, each pouch is stored independently, making it easy to retrieve and freeze at low temperatures.
It enables rapid dispensing, storage, and efficient production of DC cell vaccines, ensuring cell viability, improving production efficiency, and facilitating dispensing and use.
Smart Images
Figure CN223835862U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of biomedical technology, and more specifically to a DC cell (dendritic cell) vaccine dispensing and storage device. Background Technology
[0002] Dendritic cells (DCs) are important antigen-presenting cells that can take up and process antigens, present them to T lymphocytes, and initiate the patient's own specific anti-tumor immune response.
[0003] Currently, DC cell vaccine dispensing requires first mixing with a pipette, then individually dispensing the liquid into cryovials. Because DC cells are large, they tend to sink under their own weight. In mass production, to prevent uneven distribution of DC cells during dispensing, it is necessary to continuously mix and then individually dispense from cryovials. Furthermore, prolonged handling at room temperature can easily damage the DC cells, necessitating immediate freezing of the cryovials. This process results in low production efficiency, and failure to freeze the DC cells promptly can also cause damage.
[0004] In view of this, the inventors have designed a DC cell vaccine dispensing and storage device to solve the above problems. Utility Model Content
[0005] To address the shortcomings of existing technologies, the purpose of this invention is to provide a DC cell vaccine dispensing and storage device. Its advantages include the ability to dispense and store large quantities of DC cell vaccines at once, and the convenience of retrieving the dispensed and stored DC cell vaccines and placing them in a low-temperature cryopreservation device. When retrieving and using the dispensed and stored DC cell vaccines, they can be quickly and conveniently disassembled for use, thereby improving production efficiency, ensuring the activity of DC cell vaccines, and facilitating disassembly and use.
[0006] To achieve the above objectives, this utility model provides the following technical solution: a DC cell vaccine dispensing and storage device, comprising a plurality of storage soft bags arranged in a straight line and integrally formed, wherein each of the storage soft bags is provided with a guide tube extending along the arrangement direction and communicating with the interior of each of the storage soft bags. One end of the guide tube is sealed, and the other end is provided with a connecting interface communicating with the interior of the tube. The connecting interface is provided with a connecting sealing connector for connecting with an external syringe and for fitting the connecting interface. A flow-blocking clamp is provided on the guide tube between two storage soft bags for sealing the guide tube. Indicators for heat-sealing the guide tube are provided on the guide tube and on both sides adjacent to the flow-blocking clamp. The plurality of storage soft bags and the guide tube are integrally formed by a flexible and deformable material.
[0007] By adopting the above technical solution, when DC cell vaccine needs to be packaged and stored, several flow-blocking clamps are first removed. At this time, the storage soft bag and the inside of the feed tube are in a vacuum state. Then, the adapter sealing connector is interference-fitted with the external syringe, and then the adapter sealing connector is opened to connect the external syringe with the feed tube. The external syringe then injects the DC cell vaccine into the interface through the adapter sealing connector, and then into the storage soft bag along the feed tube. The DC cell vaccine can be quickly packaged into each storage soft bag. Next, the adapter sealing connector is closed and the flow-blocking clamp is installed in the feed tube between two storage soft bags, so that each storage soft bag is independent and effectively ensures that the DC cells in each storage soft bag are evenly distributed. Then, the heat-sealing device is used to heat-seal the two indicators on the feed tube between the two storage soft bags, so that the adjacent storage soft bags are completely isolated. Finally, the adapter sealing connector is separated from the external syringe and the DC cell vaccine packaging and storage device is taken out and frozen for storage. When the DC cell vaccine needs to be used, the flow-blocking clamps can be removed first, and the storage soft bag to be used can be cut before use.
[0008] In summary, by connecting several storage bags through a feed tube and isolating them from the outside environment via a sealing adapter, DC cell vaccine can be quickly filled into several storage bags. Furthermore, the heat treatment process using flow-blocking clamps and indicators ensures that each storage bag is independent and easy to handle. This allows for the simultaneous packaging and storage of large quantities of DC cell vaccine, facilitating the removal of the packaged and stored vaccine for placement in cryogenic storage. The packaged and stored DC cell vaccine can also be quickly and easily disassembled for use, thereby improving production efficiency, ensuring the activity of the DC cell vaccine, and providing convenient disassembly and use.
[0009] The present invention is further configured as follows: the adapter sealing joint includes an adapter pipe fixedly connected to the mating interface, a clearance opening disposed on the wall of the adapter pipe and communicating with its interior, a fastening member hinged to the clearance opening and snapped into the adapter pipe, a concave clamp disposed on the inner wall of the adapter pipe and located at the clearance opening, and a convex clamp disposed on the fastening member and used to cooperate with the concave clamp to tighten and close the guide tube. The fastening member is provided with a buckle at its hinged end, and the adapter pipe is provided with a snap-fit block that cooperates with the buckle. The guide tube is inserted into the interior of the adapter pipe and the clearance opening is located on the outer wall of the guide tube.
[0010] By adopting the above technical solution, when it is necessary to open the adapter sealing joint, the buckle and the snap-fit block can be disengaged. Then, the fastening component is rotated, which causes the convex clamp and the concave clamp to separate, thereby opening the guide tube clamped between the convex clamp and the concave clamp, allowing the DC cell vaccine to flow into each storage soft bag through the guide tube. When it is necessary to close the adapter sealing joint, the fastening component and the clearance opening can be rotated to close the convex clamp and the concave clamp on the fastening component, clamping and closing the guide tube. Finally, the buckle and the snap-fit block are snapped together.
[0011] The present invention is further configured such that: the flow-blocking clamp includes two symmetrically arranged and mutually fitted clamps for tightening and closing the feed tube, and an arc-shaped elastic arm with both ends fixed to the corresponding clamps and for applying a closing force to the two clamps.
[0012] By adopting the above technical solution, when it is necessary to close the guide tube, a force can be applied to the two clamps away from both of them. Then, the two clamps are applied to the guide tube and the two clamps are released. Under the action of the arc-shaped elastic arm, the two clamps are tightly fitted together and the guide tube is clamped and closed.
[0013] The present invention is further configured such that: the storage soft bag is in the shape of a cuboid, the guide tube is located at one end of the storage soft bag in the extending direction, and the end of the storage soft bag away from the guide tube is provided with a pouring end that communicates with and forms a seal with the interior of the guide tube.
[0014] By adopting the above technical solution, the pouring end can be set up to facilitate the drainage of DC cell vaccines by cutting and breaking the pouring end when using the soft bag for individual cutting and storage.
[0015] The present invention is further configured such that: a cutting groove is provided between two adjacent storage soft bags, extending along the length direction of the storage soft bag to between two indicators at the corresponding guide tube, and for convenient cutting.
[0016] By adopting the above technical solution, the cutting groove facilitates the cutting and separation of two adjacent storage soft bags.
[0017] The present invention is further configured such that the pouring end is provided with a cutting opening for easy cutting of the pouring end.
[0018] By adopting the above technical solution, the cutting opening is designed to facilitate cutting and opening of the pouring end.
[0019] The present invention is further configured such that the storage soft bag and the guide tube are integrally formed by EVA plastic.
[0020] In summary, this utility model has the following advantages:
[0021] 1. By connecting several storage soft bags through a feed tube and isolating them from the outside world through a connecting sealing joint, DC cell vaccine can be quickly filled into several storage soft bags. The heat treatment process of flow-blocking clamps and indicators ensures that each storage soft bag is independent and easy to handle and use. This allows for the one-time packaging and storage of large quantities of DC cell vaccine. It also facilitates the removal of the packaged and stored DC cell vaccine and its placement in low-temperature freezing equipment. When using the packaged and stored DC cell vaccine, it can be quickly and easily disassembled and used, thereby improving production efficiency, ensuring the activity of DC cell vaccine, and facilitating disassembly and use.
[0022] 2. When it is necessary to open the adapter sealing joint, the buckle and the locking block can be disengaged. Then, the fastening part can be rotated, which will cause the convex clamp and the concave clamp to separate, thereby opening the guide tube clamped between the convex clamp and the concave clamp, allowing the DC cell vaccine to flow into each storage soft bag through the guide tube. When it is necessary to close the adapter sealing joint, the fastening part and the clearance opening can be rotated to close the convex clamp and the concave clamp on the fastening part, clamping and closing the guide tube. Finally, the buckle and the locking block can be locked together.
[0023] 3. When it is necessary to close the guide tube, apply a force away from both of them to the two clamps, then apply the two clamps to the guide tube and release the two clamps. Under the action of the arc-shaped elastic arm, the two clamps will fit tightly together and clamp the guide tube closed. Attached Figure Description
[0024] Figure 1 This is a schematic diagram of the overall structure of this embodiment;
[0025] Figure 2 This is a schematic diagram of the adapter sealing joint in this embodiment.
[0026] Explanation of reference numerals in the attached drawings: 1. Storage soft bag; 2. Feed guide tube; 4. Adapter sealing joint; 41. Adapter tube; 42. Clearance opening; 43. Fastener; 44. Concave clamp; 45. Convex clamp; 46. Buckle; 47. Snap block; 5. Flow-blocking clamp; 51. Clamp; 52. Arc-shaped elastic arm; 6. Indicator; 7. Discharge end; 8. Cutting groove; 9. Cutting opening. Detailed Implementation
[0027] The present invention will be further described in detail below with reference to the accompanying drawings.
[0028] A DC cell vaccine dispensing and storage device, such as Figure 1 , 2As shown, the device includes several storage soft bags 1 arranged in a straight line and integrally formed. Each of the storage soft bags 1 has an integrally formed guide tube 2 extending along its arrangement direction and communicating with the interior of each storage soft bag 1. One end of the guide tube 2 is sealed, and the other end has a connection interface communicating with its interior. A connecting sealing connector 4 is installed on the connection interface to connect with an external syringe and to seal the connection interface. A flow-blocking clamp 5 is installed on the guide tube 2 between two storage soft bags 1 to seal the guide tube 2. A flow-blocking clamp 5 is also installed on the guide tube 2 between the connecting sealing connector 4 and the storage soft bag 1. Indicator marks 6 for heat-sealing the guide tube 2 are engraved on both sides of the guide tube 2 adjacent to the flow-blocking clamp 5. Indicator marks 6 are also engraved on the guide tube 2 between the connecting sealing connector 4 and the storage soft bag 1. The storage soft bags 1 and the guide tube 2 are integrally formed from a flexible, deformable material, specifically EVA plastic.
[0029] Furthermore, the storage soft bag 1 is arranged in the shape of a cuboid, and the guide tube 2 is located at one end of the storage soft bag 1 in the extension direction. The end of the storage soft bag 1 away from the guide tube 2 is provided with a pouring end 7 that communicates with its interior and forms a seal. When the storage soft bag 1 is cut and used separately, it is convenient to cut and drain the DC cell vaccine from the pouring end 7.
[0030] like Figure 1 , 2 As shown, the adapter sealing joint 4 includes an adapter pipe 41 fixedly connected to the mating interface, a relief opening 42 opened on the wall of the adapter pipe 41 and communicating with its interior, a fastening member 43 hinged to the relief opening 42 and snapped into the adapter pipe 41, a concave clamp 44 installed on the inner wall of the adapter pipe 41 and located at the relief opening 42, and a convex clamp 45 installed on the fastening member 43 and used to cooperate with the concave clamp 44 to tighten and close the guide tube 2. A buckle 46 is installed on the end of the fastening member 43 away from its hinge, and a snap-fit block 47 that cooperates with the buckle 46 is fixed on the adapter pipe 41. The guide tube 2 is inserted into the interior of the adapter pipe 41 and the relief opening 42 is located on the outer wall of the guide tube 2.
[0031] When it is necessary to open the adapter sealing joint 4, the buckle 46 can be disengaged from the locking block 47. Then, the fastening member 43 is rotated, which causes the convex clamp 45 and the concave clamp 44 to separate, thereby opening the guide tube 2 clamped between the convex clamp 45 and the concave clamp 44, allowing the DC cell vaccine to flow into each storage soft bag 1 through the guide tube 2. When it is necessary to close the adapter sealing joint 4, the fastening member 43 and the relief port 42 can be rotated to close, causing the convex clamp 45 and the concave clamp 44 on the fastening member 43 to close, and clamping the guide tube 2 tightly. Finally, the buckle 46 and the locking block 47 are locked together.
[0032] like Figure 1As shown, the flow-blocking clamp 5 includes two symmetrically arranged and mutually fitted clamps 51 for tightening and closing the feed tube 2, and an arc-shaped elastic arm 52 with its two ends respectively fixed to the corresponding clamps 51 for applying a closing force to the two clamps 51. When it is necessary to close the feed tube 2, a force away from both clamps can be applied to the two clamps 51. Then, the two clamps 51 are applied to the feed tube 2, and the two clamps 51 are released. Under the action of the arc-shaped elastic arm 52, the two clamps 51 are tightly fitted together, clamping and closing the feed tube 2.
[0033] like Figure 1 As shown, a cutting groove 8 is provided between two adjacent storage soft bags 1, extending along the length of the storage soft bag 1 to between two indicator marks 6 at the corresponding guide tube 2, and is used for convenient cutting, so that the two adjacent storage soft bags 1 can be cut and separated.
[0034] like Figure 1 As shown, the pouring end 7 has a cutting opening 9 for easy cutting and opening.
[0035] The working process and beneficial effects of this utility model are as follows: When it is necessary to dispense and store DC cell vaccines, first remove several flow-blocking clamps 5. At this time, the storage soft bag 1 and the feed tube 2 are in a vacuum state. Then, the adapter sealing connector 4 is press-fitted with the external syringe. Then, the adapter sealing connector 4 is opened to allow the external syringe to communicate with the feed tube 2. Immediately afterwards, the external syringe injects the DC cell vaccine into the interface through the adapter sealing connector 4, and then into the storage soft bag 1 along the feed tube 2. The DC cell vaccine can be quickly dispensed into each storage soft bag 1. Then, the adapter sealing connector 4 is closed. The connector 4 is closed and the flow-blocking clamp 5 is installed on the feed tube 2 between the two storage soft bags 1, so that each storage soft bag 1 is independent and the DC cells in each storage soft bag 1 are evenly distributed. Then, the heat-sealing device is used to heat-seal the two indicators 6 on the feed tube 2 between the two storage soft bags 1, so that the adjacent storage soft bags 1 are completely isolated. Finally, the adapter sealing connector 4 is separated from the external syringe and the DC cell vaccine dispensing and storage device is taken out and frozen for storage. When the DC cell vaccine is needed, the flow-blocking clamp 5 can be removed first, and the storage soft bag 1 to be used can be cut before use.
[0036] In summary, by connecting several storage soft bags 1 through the feed pipe 2 and isolating them from the outside world through the adapter sealing joint 4, DC cell vaccine can be quickly filled into several storage soft bags 1. The heat treatment process of the flow-blocking clamp 5 and the indicator 6 ensures that each storage soft bag 1 is independent and easy to handle and use. This allows for the one-time packaging and storage of a large number of DC cell vaccines, and facilitates the removal of the packaged and stored DC cell vaccines and their placement in low-temperature freezing equipment. When using the packaged and stored DC cell vaccines, they can be quickly and easily disassembled and used, thereby improving production efficiency, ensuring the activity of DC cell vaccines, and providing convenient disassembly and use.
[0037] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the design concept of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A DC cell vaccine dispensing and storage device, characterized in that: The system includes several storage soft bags (1) arranged in a straight line and integrally formed. Each of the storage soft bags (1) has a guide tube (2) extending along its arrangement direction and communicating with the interior of each storage soft bag (1) one by one. One end of the guide tube (2) is sealed, and the other end is provided with a connecting interface communicating with its interior. The connecting interface is provided with a connecting sealing connector (4) for connecting with an external syringe and for fitting the connecting interface. A flow-blocking clamp (5) is provided on the guide tube (2) between two storage soft bags (1) for sealing the guide tube (2). An indicator (6) for heat-sealing the guide tube (2) is provided on the guide tube (2) and on both sides adjacent to the flow-blocking clamp (5). The storage soft bags (1) and the guide tube (2) are integrally formed by flexible and deformable material.
2. The DC cell vaccine dispensing and storage device according to claim 1, characterized in that: The adapter sealing joint (4) includes an adapter pipe (41) fixedly connected to the interface, a relief opening (42) disposed on the wall of the adapter pipe (41) and communicating with its interior, a fastening member (43) hinged to the relief opening (42) and snapped into the adapter pipe (41), a concave clamp (44) disposed on the inner wall of the adapter pipe (41) and located at the relief opening (42), and a convex clamp (45) disposed on the fastening member (43) and used to cooperate with the concave clamp (44) to tighten and close the guide tube (2). The fastening member (43) has a buckle (46) at one end away from its hinge. The adapter pipe (41) is provided with a snap block (47) that cooperates with the buckle (46). The guide tube (2) is inserted inside the adapter pipe (41) and the relief opening (42) is located on the outer wall of the guide tube (2).
3. The DC cell vaccine dispensing and storage device according to claim 1, characterized in that: The flow-blocking clamp (5) includes two symmetrically arranged and mutually fitted clamps (51) for tightening and closing the feed tube (2), and an arc-shaped elastic arm (52) with its two ends respectively fixed to the corresponding clamps (51) and for applying a closing force to the two clamps (51).
4. The DC cell vaccine dispensing and storage device according to claim 1, characterized in that: The storage soft bag (1) is rectangular in shape, the guide tube (2) is located at one end of the storage soft bag (1) in the extension direction, and the end of the storage soft bag (1) away from the guide tube (2) is provided with a pouring end (7) that communicates with its interior and forms a seal.
5. A DC cell vaccine dispensing and storage device according to claim 4, characterized in that: A cutting groove (8) is provided between two adjacent storage soft bags (1) and extends along the length of the storage soft bag (1) to between two indicators (6) at the corresponding guide tube (2) for convenient cutting.
6. The DC cell vaccine dispensing and storage device according to claim 4, characterized in that: The pouring end (7) is provided with a cutting opening (9) for easy cutting.
7. A DC cell vaccine dispensing and storage device according to claim 1, characterized in that: The storage soft bag (1) and the feed tube (2) are integrally formed by EVA plastic.