Full-automatic solid-phase extraction instrument

Abstract

The utility model discloses a full-automatic solid-phase extraction instrument, which belongs to the technical field of solid-phase extraction instruments, and has the technical key points that the full-automatic solid-phase extraction instrument comprises a bottom plate, stations on an extraction column can be moved and switched one by one through an arranged extraction station switching mechanism, the automation degree is high, the manual operation is reduced, and the production efficiency is improved. The extraction station switching mechanism can synchronously drive the extraction liquid dropping mechanism to operate, that is, when the extraction column moves by one station, the liquid injection pipe can correspondingly extract a proper amount of liquid for liquid dropping operation, the automatic operation mode greatly shortens the time required by the extraction process, the overall working efficiency is improved, and the labor intensity of workers is reduced. The liquid injection amount of the liquid injection pipe can be adjusted and used through the arranged extraction adjusting mechanism, so that an operator can better adjust the volume of a solvent dropwise added each time according to specific experiment requirements, the extraction conditions are optimized, meanwhile, the universality and practicability of the equipment are improved, and the production efficiency is improved. The device has the advantages of high automation degree, convenience in extraction processing and high working efficiency.

Description

TECHNICAL FIELD

[0001] The utility model relates to solid phase extraction appearance field, concretely relates to a full -automatic solid phase extraction appearance. BACKGROUND

[0002] The background technique of full -automatic solid phase extraction appearance originates from the combination of liquid-solid extraction and liquid chromatography technology, and this technology has gradually developed since the middle of the eighties, and has been widely used in many fields such as environmental science and technology, food safety detection and chemical production laboratory.The working principle of solid phase extraction appearance is based on liquid-solid chromatography theory, and the sample is enriched, separated and purified by selective adsorption and selective elution.

[0003] At present, the traditional solid phase extraction often needs to pass through four steps of activation, sample loading, washing and elution in sequence during operation, activation is to wet the filler in the extraction column, sample loading is the process of transferring the pretreated sample to the solid phase extraction column, the purpose of washing is to remove the interferents to the greatest extent, so that the target compounds can be better collected in the subsequent elution step, and elution is the process of eluting the measured substances from the solid phase extraction column with a small amount of solvent and collecting, but each step needs to manually take a rubber bulb dropper to extract a certain amount of liquid and add it to the solid phase extraction column for processing, first, the manual operation of the rubber bulb dropper cannot guarantee that the liquid amount added each time is completely consistent, and in the process of manual operation, the rubber bulb dropper may contact the test tube wall or other contaminants, thereby introducing impurities, which is tedious and time-consuming, thereby greatly reducing the work efficiency, and cannot meet the actual use needs.

[0004] Therefore, it is necessary to provide a full -automatic solid phase extraction appearance, aiming at solving the above problems. UTILITY MODEL CONTENT

[0005] In view of the deficiencies existing in the prior art, the purpose of the utility model embodiment is to provide a full -automatic solid phase extraction appearance, aiming at solving the technical problems proposed in the background art.

[0006] In order to achieve the above-mentioned purpose, the utility model provides the following technical scheme:

[0007] A full -automatic solid phase extraction appearance, including bottom plate, the bottom plate is sequentially arranged with activation mechanism, sample loading mechanism, washing mechanism and elution mechanism, the activation mechanism, sample loading mechanism, washing mechanism and elution mechanism all are provided with extraction mechanism, the extraction mechanism includes the extraction column for extraction and the observation window for placing a plurality of extraction columns, further including:

[0008] The extraction station switching mechanism is installed at the joint of the placing box and the bottom plate, is used for advancing the extraction column to carry out extraction operation one by one, and comprises a conveying belt used for station advancing connection, a driving turntable and a driven turntable, the conveying belt is intermittently conveyed by the rotation of the driving turntable and the driven turntable, the driving turntable is provided with a driving rod used for driving the driven turntable to rotate intermittently, and the driving rod is fixedly installed at the center of the driving turntable through a fixed connecting rod;

[0009] The extraction drop mechanism is installed in the vertical plate and is arranged above the extraction column, is synchronously driven by the extraction station switching mechanism, is used for drop processing following the station movement of the extraction column, and comprises a liquid injection pipe used for drop connection, a lifting rod and a clamping block, the liquid injection pipe is communicated with a liquid guide pipe through an elastic hose, the liquid guide pipe is communicated with a liquid injection cylinder used for liquid injection connection, a piston plate used for liquid pumping connection is arranged in the liquid injection cylinder, the piston plate is limitingly and slidingly connected to the inside of the liquid injection cylinder through a piston rod, the clamping block is fixedly connected with the lifting rod through a traction rod, the liquid injection pipe is clamped and installed on the clamping block, and the lifting rod is liftingly installed in the inside of the vertical plate.

[0010] The extraction adjusting mechanism is installed in the vertical plate and is arranged at one side of the end of the liquid injection cylinder, is used for adjusting the liquid pumping amount in the liquid injection cylinder, and comprises an adjusting touch rod used for adjusting the extension length of the piston rod, and the adjusting touch rod is limitingly and movably installed on the piston rod.

[0011] As a further scheme of the utility model, the extraction station switching mechanism further comprises a driving motor used for driving the driving turntable to rotate, the driving turntable is rotatably installed on the vertical plate through a connecting shaft, the connecting shaft is fixedly connected with the output shaft of the driving motor, the driving motor is fixedly installed in the inside of the vertical plate, the driven turntable is provided with a first sliding groove matched with the driving rod, and the driven turntable is further provided with a second sliding groove matched with the driving turntable for sliding connection, and the driven turntable is rotatably installed on the vertical plate through a driving roller.

[0012] As a further scheme of the utility model, the extraction station switching mechanism further comprises a conveying belt used for driving the placing box to move, the conveying belt is drivingly connected with the driving roller and the driven roller, the driven roller and the driving roller are rotatably installed on one side of the vertical plate through a roller support seat, the conveying belt is provided with a limiting strip and a positioning plate used for positioning connection, and one side of the conveying belt is provided with a placing table.

[0013] As a further scheme of the utility model, the placing box is provided with an observation window used for observation, and the placing box is further provided with a metal box door used for opening and closing, the metal box door is rotatably installed on the placing box through a box door rotating shaft, and the placing box is provided with a magnet magnetically connected with the metal box door.

[0014] As a further scheme of the utility model, the extraction liquid drop mechanism further includes a second cam and a second guide wheel for liquid injection driving, the second cam is fixedly connected to the connecting shaft, a second limiting guide groove adapted to slidingly connect the second guide wheel is formed in the second cam, the second guide wheel is rotatably installed at one end of the adjusting cylinder, the adjusting cylinder is limitingly and slidingly connected to the second support plate through the limiting guide block, a second guide groove adapted to slidingly connect the adjusting cylinder and the limiting guide block is formed in the second support plate, the piston rod is limitingly and slidingly connected to the interior of the vertical plate through the first support plate, and a first limiting plate is arranged on the adjusting cylinder, and a first spring is arranged at the connecting position of the first limiting plate and the first support plate.

[0015] As a further scheme of the utility model, the extraction liquid drop mechanism further includes a first cam and a first guide wheel for driving the liquid injection pipe to lift and drop liquid connection, the first guide wheel is rotatably installed on the lifting rod, a first limiting guide groove adapted to slidingly connect the first guide wheel is formed in the first cam, and the first cam and the second cam are arranged at a 90° angle, the lifting rod is limitingly and slidingly connected to the interior of the guide frame through the lifting plate, the guide frame is fixedly installed in the interior of the vertical plate, and a tightening knob for fastening is arranged at the connecting position of the clamping block and the liquid injection pipe.

[0016] As a further scheme of the utility model, the extraction liquid drop mechanism further includes a liquid storage tank for infusion connection, the liquid storage tank is communicated with the interior of the liquid injection cylinder through the liquid pumping pipe, a liquid pumping check valve is arranged on the liquid pumping pipe, and a liquid inlet check valve is arranged at the connecting position of the liquid guide pipe and the liquid injection cylinder.

[0017] As a further scheme of the utility model, the extraction adjusting mechanism further includes limiting holes for adapting to clamp and adjust the touch rod, the limiting holes are a plurality of and equidistantly formed on the adjusting cylinder, a first guide groove adapted to slidingly connect the touch rod is formed in the interior of the adjusting cylinder, a second spring is arranged at the connecting position of the touch rod and the piston rod, the piston rod is slidingly connected to the interior of the adjusting cylinder through the guide rod, a second limiting plate is arranged on the piston rod, and a maintenance door is arranged on one side of the vertical plate.

[0018] In summary, the utility model embodiment has the following beneficial effects compared with the prior art:

[0019] The utility model discloses a setting extraction station switching mechanism can realize the moving switching processing of extraction column's post one by one, realized the automation control of extraction process, reduced manual operation, improved work efficiency, not only reduced the error of manual operation, and improved the accuracy and repeatability of experiment, can make the process continuous of extraction drop simultaneously, and this continuous operation mode can improve extraction efficiency significantly, shorten the experimental time, be convenient for extraction operation use.

[0020] Through the setting extraction station switching mechanism can synchronous drive extraction drop liquid mechanism and operate, namely, when extraction column moves a post, injection tube can be extracted the appropriate liquid drop liquid operation, and this automatic operation mode greatly shortens the time required in extraction process, need not manually adjust the height of injection tube or control drop liquid speed, reduces the labor intensity of operator simultaneously, makes them be able to concentrate on other more important task, thereby improves the overall work efficiency.

[0021] Through the setting extraction adjustment mechanism can realize the adjustment of injection tube injection volume, and this adjustable operation mode makes operator can adjust the solvent volume of each drop according to the specific experimental demand, optimizes the extraction condition, thereby makes the proportion between solvent and sample reach the best state, thereby improves extraction efficiency, in addition, through the control injection volume, it is helpful to avoid the excessive use of solvent, is favorable to the environmental management of laboratory, and the adjustable injection volume mode makes the same set of equipment can adapt to a variety of different sample types, improves the versatility and practicality of equipment, thereby brings all-round improvement for extraction experiment.

[0022] In order to more clearly set forth the structural features and efficacy of the utility model, below, combining with the specific embodiment and the detailed description of the utility model are carried out. ACCURACY

[0023] Figure 1 It is the structural schematic diagram of utility model embodiment.

[0024] Figure 2 It is the structural schematic diagram of utility model embodiment's side view.

[0025] Figure 3 It is the connection structure schematic diagram of utility model embodiment's conveying belt.

[0026] Figure 4 It is Figure 3 It is the enlarged structural schematic diagram of A.

[0027] Figure 5 It is Figure 3 It is the enlarged structural schematic diagram of B.

[0028] Figure 6The side view structure schematic diagram of the connection of the stand plate in the utility model embodiment.

[0029] Figure 7 The side view structure schematic diagram of the connection of the stand plate in the utility model embodiment.

[0030] Figure 8 For Figure 7 The enlarged structure schematic diagram of the middle C.

[0031] Figure 9 The sectional structure schematic diagram of the connection of the liquid injection cylinder in the utility model embodiment.

[0032] Figure 10 For Figure 9 The enlarged structure schematic diagram of the middle D.

[0033] Figure 11 The sectional structure schematic diagram of the connection of the adjusting cylinder in the utility model embodiment.

[0034] Figure 12 For Figure 11 The enlarged structure schematic diagram of the middle E.

[0035] Figure 13 The side view structure schematic diagram of the connection of the adjusting cylinder in the utility model embodiment.

[0036] Figure 14 The structure schematic diagram of the metal box door in the open state in the utility model embodiment.

[0037] 1, bottom plate; 2, activation mechanism; 3, sample loading mechanism; 4, elution mechanism; 5, elution mechanism; 6, vertical plate; 7, maintenance door; 8, placement box; 9, observation window; 10, extraction column; 11, metal box door; 12, box door hinge; 13, magnet; 14, conveyor belt; 15, limiting strip; 16, positioning plate; 17, driven roller; 18, driving roller; 19, roller support; 20, driven turntable; 21, first chute; 22, second chute; 23, drive rod; 24, fixed connecting rod; 25, driving turntable; 26, connecting shaft; 27, first cam; 28, second cam; 29, drive motor; 30, first limiting guide groove; 31, second limiting guide groove; 32, first guide wheel; 33, lifting rod; 34, lifting plate; 35, guide frame; 36, traction rod; 37, clamping block; 38, tightening knob; 39, liquid injection pipe; 40, elastic hose; 41, liquid guide pipe; 42, liquid inlet check valve; 43, liquid injection cylinder; 44, liquid suction pipe; 45, liquid suction check valve; 46, liquid storage tank; 47, piston plate; 48, piston rod; 49, first support plate; 50, first spring; 51, first limiting plate; 52, adjusting cylinder; 53, limiting guide block; 54, second support plate; 55, second guide wheel; 56, second limiting plate; 57, guide rod; 58, adjusting touch rod; 59, second spring; 60, limiting hole; 61, first guide groove; 62, placement table; 63, second guide groove. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical scheme and advantages of the utility model more clear, the following will be further described in detail in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the utility model and not to limit the utility model.

[0039] The specific implementation of the utility model will be described in detail in combination with specific examples. Example 1

[0040] Referring to Figures 1-14 A full-automatic solid phase extraction instrument, comprising a bottom plate 1, the bottom plate 1 is sequentially arranged with an activation mechanism 2, a sample loading mechanism 3, an elution mechanism 4 and an elution mechanism 5, the activation mechanism 2, the sample loading mechanism 3, the elution mechanism 4 and the elution mechanism 5 are all provided with an extraction mechanism, the extraction mechanism comprises an extraction column 10 for extraction and an observation window 9 for placing a plurality of extraction columns 10, further comprising:

[0041] The extraction station switching mechanism is installed at the joint of the placing box 8 and the bottom plate 1, and is used to advance the extraction column 10 for extraction operation. The extraction station switching mechanism comprises a conveying belt 14 for station advancing connection, a driving turntable 25 and a driven turntable 20. The conveying belt 14 is intermittently conveyed by the rotation of the driving turntable 25 and the driven turntable 20. The driving turntable 25 is provided with a driving rod 23 for driving the intermittent rotation of the driven turntable 20. The driving rod 23 is fixedly installed at the center of the driving turntable 25 through a fixed connecting rod 24.

[0042] Further, the extraction station switching mechanism further comprises a driving motor 29 for driving the rotation of the driving turntable 25. The driving turntable 25 is rotatably installed on the stand plate 6 through a connecting shaft 26. The connecting shaft 26 is fixedly connected to the output shaft of the driving motor 29. The driving motor 29 is fixedly installed inside the stand plate 6. The driven turntable 20 is provided with a first sliding groove 21 adapted to the driving rod 23. The driven turntable 20 is further provided with a second sliding groove 22 adapted to the sliding connection of the driving turntable 25. The driven turntable 20 is rotatably installed on the stand plate 6 through the driving roller 18.

[0043] Further, the extraction station switching mechanism further comprises the conveying belt 14 for driving the conveying movement of the placing box 8. The conveying belt 14 is drivingly connected to the driving roller 18 and the driven roller 17. The driven roller 17 and the driving roller 18 are rotatably installed on one side of the stand plate 6 through a roller support seat 19. The conveying belt 14 is provided with a limiting strip 15 and a positioning plate 16 for positioning connection. One side of the conveying belt 14 is provided with a placing table 62.

[0044] Further, the placing box 8 is provided with an observation window 9 for observation. The placing box 8 is further provided with a metal box door 11 for opening and closing. The metal box door 11 is rotatably installed on the placing box 8 through a box door rotating shaft 12. The placing box 8 is provided with a magnet 13 magnetically connected to the metal box door 11.

[0045] Preferably, during the extraction operation, a plurality of extraction columns 10 are placed and installed on the placing box 8 in advance. The liquid injection condition of the extraction column 10 in the placing box 8 can be observed through the observation window 9. The metal box door 11 can be opened to facilitate the placement of a corresponding container for collecting and processing liquid or waste liquid. Since the placing box 8 is provided with the magnet 13 magnetically connected to the metal box door 11, the metal box door 11 can be locked and opened.

[0046] The placement box 8 is clamped on the conveying belt 14 by the limiting strip 15 and the positioning plate 16, and can be processed one by one according to the structures on the activation mechanism 2, the sample loading mechanism 3, the elution mechanism 4 and the elution mechanism 5 when the four steps of activation, sample loading, elution and elution are carried out one by one. The top of the extraction column 10 is provided with a liquid injection pipe 39 for drop liquid. When the liquid injection pipe 39 completes the drop liquid operation of one station, the driving motor 29 drives the driving turntable 25 on the connecting shaft 26 to rotate, so that the driving rod 23 on the fixed connecting rod 24 and the first sliding groove 21 on the driven turntable 20 are adaptively and slidingly connected, the driven turntable 20 drives the driving roller 18 to rotate clockwise by a certain angle, and the conveying belt 14 drives the extraction column 10 on the placement box 8 to switch one station under the synchronous transmission of the driven roller 17, so as to facilitate the subsequent extraction drop liquid operation.

[0047] Through this way of switching one by one, the automatic control of the extraction process can be realized, the manual operation is reduced, the work efficiency is improved, the manpower is saved, the error caused by manual operation is reduced, the accuracy and repeatability of the experiment are improved, the extraction drop liquid process can be continuously carried out, and the traditional method of waiting for a single extraction column to complete the extraction drop liquid before carrying out the next step is avoided. This continuous operation mode can significantly improve the extraction efficiency, shorten the experimental time, and facilitate the extraction operation. Embodiment 2

[0048] As shown in Figures 1-13 the embodiment, based on the embodiment 1, the extraction drop liquid mechanism is further included, which is installed in the vertical plate 6 and located above the extraction column 10, is synchronously driven by the extraction station switching mechanism, is used for drop liquid processing following the station movement of the extraction column 10, and includes the liquid injection pipe 39 for drop liquid connection, the lifting rod 33 and the clamping block 37. The liquid injection pipe 39 is communicated with the liquid guide pipe 41 through the elastic hose 40, the liquid guide pipe 41 is communicated with the liquid injection cylinder 43 for liquid injection connection, the liquid injection cylinder 43 is provided with the piston plate 47 for liquid pumping connection, the piston plate 47 is limitingly and slidingly connected to the inside of the liquid injection cylinder 43 through the piston rod 48, the clamping block 37 is fixedly connected with the lifting rod 33 through the traction rod 36, the liquid injection pipe 39 is clamped and installed on the clamping block 37, and the lifting rod 33 is movably installed in the inside of the vertical plate 6.

[0049] The extraction adjusting mechanism is installed in the vertical plate 6 and located at one side of the end of the liquid injection cylinder 43, and is used for adjusting the pumping amount in the liquid injection cylinder 43. The extraction adjusting mechanism includes the adjusting touch rod 58 for adjusting the extension length of the piston rod 48, and the adjusting touch rod 58 is limitingly and movably installed on the piston rod 48.

[0050] Further, the extraction drop mechanism further comprises a second cam 28 and a second guide wheel 55 for injection driving, the second cam 28 is fixedly connected to the connecting shaft 26, a second limiting guide groove 31 is formed in the second cam 28 and adapted to slidingly connect the second guide wheel 55, the second guide wheel 55 is rotatably installed at one end of an adjusting cylinder 52, the adjusting cylinder 52 is limitingly and slidingly connected to a second supporting plate 54 through a limiting guide block 53, a second guide groove 63 is formed in the second supporting plate 54 and adapted to slidingly connect the adjusting cylinder 52 and the limiting guide block 53, the piston rod 48 is limitingly and slidingly connected to the interior of the vertical plate 6 through a first supporting plate 49, and a first limiting plate 51 is arranged on the adjusting cylinder 52, and a first spring 50 is arranged at the connection between the first limiting plate 51 and the first supporting plate 49.

[0051] Further, the extraction drop mechanism further comprises a first cam 27 and a first guide wheel 32 for driving the injection tube 39 to move up and down for drop connection, the first guide wheel 32 is rotatably installed on a lifting rod 33, a first limiting guide groove 30 is formed in the first cam 27 and adapted to slidingly connect the first guide wheel 32, and the first cam 27 is arranged at a 90° angle with the second cam 28, the lifting rod 33 is limitingly and slidingly connected to the interior of a guide frame 35 through a lifting plate 34, the guide frame 35 is fixedly installed in the interior of the vertical plate 6, and a clamping block 37 is provided with a tightening knob 38 for tightening at the connection with the injection tube 39.

[0052] Further, the extraction drop mechanism further comprises a liquid storage tank 46 for infusion connection, the liquid storage tank 46 is communicated with the interior of an injection cylinder 43 through a liquid pumping tube 44, the liquid pumping tube 44 is provided with a liquid pumping one-way valve 45, and the liquid guide tube 41 is provided with a liquid inlet one-way valve 42 at the connection with the injection cylinder 43.

[0053] Further, the extraction adjusting mechanism further comprises limiting holes 60 for adapting clamping adjustment of the adjusting touch rod 58, the limiting holes 60 are a plurality of and equidistantly formed on the adjusting cylinder 52, a first guide groove 61 is formed in the interior of the adjusting cylinder 52 and adapted to slidingly connect the adjusting touch rod 58, a second spring 59 is arranged at the connection between the adjusting touch rod 58 and the piston rod 48, the piston rod 48 is slidingly connected to the interior of the adjusting cylinder 52 through a guide rod 57, and the piston rod 48 is provided with a second limiting plate 56 for limiting, and a maintenance door 7 is arranged on one side of the vertical plate 6.

[0054] Preferably, in the embodiment, when the conveying belt 14 drives the extraction column 10 placed on the placing box 8 to move for single station switching, the connecting shaft 26 will correspondingly drive the first cam 27 to rotate one circle, so as to drive the lifting rod 33 to move the injection tube 39 pulled by the traction rod 36 to the direction close to the extraction column 10 under the relationship that the first cam 27 is adapted to slidingly connect the first guide wheel 32 on the lifting rod 33;

[0055] Corresponding synchronization, the connecting shaft 26 also drives the second cam 28 to rotate a circle, so that in the relationship between the second cam 28 and the second guide wheel 55 of the adjusting cylinder 52, the adjusting cylinder 52 drives the piston plate 47 on the piston rod 48 to move back and forth, so that under the action of the liquid inlet one-way valve 42 arranged on the liquid guide pipe 41 and the liquid extraction one-way valve 45 arranged on the liquid extraction pipe 44, the liquid extracted by the piston plate 47 from the liquid storage tank 46 can be pushed into the liquid injection pipe 39 connected to the liquid guide pipe 41, and then the piston plate 47 is reset under the action of the first spring 50 and the second cam 28, and a certain amount of liquid is extracted in the liquid injection cylinder 43 for the next extraction operation. At this time, the liquid injection pipe 39 is close to the extraction column 10 for dripping operation, and the activation mechanism 2, the sample loading mechanism 3, the elution mechanism 4 and the elution mechanism 5 are sequentially operated for corresponding extraction operation, which is high in automation and convenient to operate.

[0056] This automatic operation mode greatly shortens the time required for the extraction process, because it is not necessary to manually adjust the height of the liquid injection pipe or control the dripping speed, and the labor intensity of the operator is reduced, so that they can focus on other more important tasks, thereby improving the overall work efficiency.

[0057] When it is necessary to adjust the amount of extraction dripping, the maintenance door 7 on the side of the vertical plate 6 can be opened, and the adjusting lever 58 is manually pressed to move towards the piston rod 48, so that the adjusting lever 58 is adjusted in position with the limiting hole 60 on the adjusting cylinder 52 under the guidance of the first guide groove 61 in the adjusting cylinder 52, that is, the extension length of the piston plate 47 connected to the one end of the piston rod 48 in the liquid injection cylinder 43 is adjusted, so that the extraction and pushing liquid amount of the piston plate 47 is improved, and the liquid injection amount of the liquid injection pipe 39 is adjusted.

[0058] This adjustable operation mode enables the operator to better adjust the volume of solvent added each time according to the specific experimental requirements, optimizes the extraction conditions, so that the ratio between the solvent and the sample reaches the best state, thereby improving the extraction efficiency. In addition, by controlling the liquid injection amount, it is helpful to avoid excessive use of solvent, thereby reducing the waste of chemical reagents and environmental pollution. Reducing the use of solvent also means reducing the generation of waste liquid, which is conducive to the environmental management of the laboratory. At the same time, the adjustable liquid injection amount mode enables the same set of equipment to adapt to various different sample types, improves the versatility and practicality of the equipment, and thus brings many aspects of improvement to the extraction experiment.

[0059] It needs to be specially pointed out that the activation mechanism 2, the sample loading mechanism 3, the elution mechanism 4 and the elution mechanism 5 are all provided with the same type of extraction mechanism, the main difference is that the reagent in the liquid storage tank 46 is different, so that the corresponding extraction operation is used, which greatly improves the extraction efficiency, and also facilitates the later maintenance use.

[0060] It needs to be specially pointed out that the components in the application are all general standard components or components known to those skilled in the art, which effectively solves the technical problems proposed in the background art.

[0061] The above only describes the preferred embodiments of the present application and does not limit the present application, and any modification, equivalent replacement and improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A fully automated solid-phase extraction apparatus, comprising a base plate (1), characterized in that, An activation mechanism (2), a sample loading mechanism (3), a rinsing mechanism (4), and an elution mechanism (5) are arranged sequentially on the base plate (1). Each of the activation mechanism (2), sample loading mechanism (3), rinsing mechanism (4), and elution mechanism (5) is equipped with an extraction mechanism. The extraction mechanism includes an extraction column (10) for extraction and an observation window (9) for placing several extraction columns (10). It also includes: An extraction station switching mechanism is installed at the connection between the placement box (8) and the base plate (1) to advance the extraction columns (10) one by one for extraction operations. The extraction station switching mechanism includes a conveyor belt (14) for station advancement connection, an active turntable (25) and a driven turntable (20). The conveyor belt (14) performs intermittent conveying through the rotation of the active turntable (25) and the driven turntable (20). The active turntable (25) is provided with a drive rod (23) for driving the driven turntable (20) to rotate intermittently. The drive rod (23) is fixedly installed at the center of the active turntable (25) through a fixed connecting rod (24). An extraction dripping mechanism is installed inside the vertical plate (6) and located above the extraction column (10). It is driven by the extraction station switching mechanism to perform synchronous dripping and is used to follow the station movement of the extraction column (10) for dripping treatment. The extraction dripping mechanism includes an injection pipe (39) for dripping connection, a lifting rod (33) and a clamping block (37). The injection pipe (39) is connected to a guide pipe (41) through an elastic hose (40). The guide pipe (41) is connected to an injection cylinder (43) for injection connection. A piston plate (47) for pumping connection is provided inside the injection cylinder (43). The piston plate (47) is slidably connected to the inside of the injection cylinder (43) through a piston rod (48). The clamping block (37) is fixedly connected to the lifting rod (33) through a traction rod (36). The injection pipe (39) is snapped onto the clamping block (37). The lifting rod (33) is movably installed inside the vertical plate (6). An extraction adjustment mechanism is installed inside the vertical plate (6) and located on one side of the end of the injection cylinder (43) for adjusting the amount of liquid drawn in the injection cylinder (43). The extraction adjustment mechanism includes an adjustment contact rod (58) for adjusting the extension length of the piston rod (48). The adjustment contact rod (58) is movably mounted on the piston rod (48).

2. The fully automated solid-phase extraction apparatus according to claim 1, characterized in that, The extraction station switching mechanism also includes a drive motor (29) for driving the active turntable (25) to rotate. The active turntable (25) is rotatably mounted on the vertical plate (6) via a connecting shaft (26). The connecting shaft (26) is fixedly connected to the output shaft of the drive motor (29). The drive motor (29) is fixedly mounted inside the vertical plate (6). The driven turntable (20) is provided with a first groove (21) adapted to connect the drive rod (23), and the driven turntable (20) is also provided with a second groove (22) adapted to slide and connect the active turntable (25). The driven turntable (20) is rotatably mounted on the vertical plate (6) via an active roller (18).

3. The fully automated solid-phase extraction apparatus according to claim 2, characterized in that, The extraction station switching mechanism also includes a conveyor belt (14) for driving the placement box (8) to move. The conveyor belt (14) is connected to the driving roller (18) and the driven roller (17). The driven roller (17) and the driving roller (18) are rotatably mounted on one side of the upright plate (6) through the roller support seat (19). The conveyor belt (14) is provided with a limiting strip (15) and a positioning plate (16) for positioning connection. A placement platform (62) is provided on one side of the conveyor belt (14).

4. The fully automated solid-phase extraction apparatus according to claim 3, characterized in that, The placement box (8) is provided with an observation window (9) for observation, and the placement box (8) is also provided with a metal box door (11) for opening and closing. The metal box door (11) is rotatably installed on the placement box (8) through a box door pivot (12). The placement box (8) is provided with a magnet (13) that is magnetically connected to the metal box door (11).

5. The fully automated solid-phase extraction apparatus according to claim 2, characterized in that, The extraction dripping mechanism further includes a second cam (28) and a second guide wheel (55) for injection driving. The second cam (28) is fixedly connected to the connecting shaft (26). The second cam (28) has a second limiting guide groove (31) adapted to slide and connect the second guide wheel (55). The second guide wheel (55) is rotatably installed at one end of the adjusting cylinder (52). The adjusting cylinder (52) is limited and slidably connected to the second support plate (54) through the limiting guide block (53). The second support plate (54) has a second guide groove (63) adapted to slide and connect the adjusting cylinder (52) and the limiting guide block (53). The piston rod (48) is limited and slidably connected to the inside of the vertical plate (6) through the first support plate (49). The adjusting cylinder (52) is provided with a first limiting plate (51). A first spring (50) is provided at the connection between the first limiting plate (51) and the first support plate (49).

6. The fully automated solid-phase extraction apparatus according to claim 5, characterized in that, The extraction dripping mechanism also includes a first cam (27) and a first guide wheel (32) for driving the injection tube (39) to make a lifting and dripping connection. The first guide wheel (32) is rotatably mounted on the lifting rod (33). The first cam (27) is provided with a first limiting guide groove (30) adapted to slide and connect the first guide wheel (32). The first cam (27) and the second cam (28) are set at a 90° angle. The lifting rod (33) is limited and slidably connected to the inside of the guide frame (35) through the lifting plate (34). The guide frame (35) is fixedly installed inside the upright plate (6). The clamping block (37) and the injection tube (39) are provided with a tightening knob (38) for fastening.

7. The fully automated solid-phase extraction apparatus according to claim 6, characterized in that, The extraction dripping mechanism also includes a storage tank (46) for infusion connection. The storage tank (46) is connected to the inside of the injection cylinder (43) through a suction pipe (44). A suction check valve (45) is provided on the suction pipe (44), and an inlet check valve (42) is provided at the connection between the liquid guide pipe (41) and the injection cylinder (43).

8. The fully automated solid-phase extraction apparatus according to claim 1, characterized in that, The extraction adjustment mechanism also includes limiting holes (60) for adapting to the snap-fit ​​adjustment contact rod (58). The number of limiting holes (60) is several and they are equally spaced on the adjustment cylinder (52). The inner side of the adjustment cylinder (52) is provided with a first guide groove (61) for adapting to the sliding connection of the adjustment contact rod (58). A second spring (59) is provided at the connection between the adjustment contact rod (58) and the piston rod (48). The piston rod (48) is guided and slidably connected to the inside of the adjustment cylinder (52) through a guide rod (57). A second limiting plate (56) is provided on the piston rod (48) for limiting. A maintenance door (7) is provided on one side of the upright plate (6).

Images