Medicine preparation tank capable of rapidly cooling and heating
By using a closed-loop jacketed heat exchanger and heat transfer medium, the heat exchange medium can be directly heated or cooled, which solves the contamination problem caused by medium replacement in injection production, achieves rapid temperature regulation, and improves the safety and efficiency of drug preparation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-19
- Publication Date
- 2026-03-31
AI Technical Summary
In the existing technology, the mutual contamination caused by different heating and cooling media during the production of injectable drugs, as well as the problem of long media replacement time that prevents rapid cooling and heating, affect the stability and safety of the drugs.
The jacketed heat exchanger with a closed-loop design directly heats or cools the heat exchange medium through the heat exchange device. It utilizes thermally conductive media with a wide temperature range, good fluidity, and low viscosity, such as silicone oil and glycerin solution, to avoid media replacement and achieve rapid temperature regulation.
It significantly shortens the temperature conditioning time, improves the purity and safety of the drug preparation process, avoids cross-contamination of media, and meets the requirements of rapid cooling and heating of heat-sensitive drugs within seconds.
Smart Images
Figure CN224057156U_ABST
Abstract
Description
TECHNICAL FIELD
[0002] The application belongs to the technical field of medicine manufacturing, and particularly relates to a medicine preparation tank capable of rapidly reducing and increasing temperature. BACKGROUND
[0004] In the production process of injections, temperature control is a key link affecting the stability of medicines and the quality of products. Some poorly soluble medicines need to be completely dissolved under heating conditions, but the molecular structure of the medicines is prone to degradation reaction in a high-temperature environment, which requires that the temperature of the medicine solution be rapidly reduced to a low-temperature storage condition in a very short time, usually within a few minutes. Since steam and liquid nitrogen are directly introduced, the pressure in the jacket is very large, which has a safety hazard, and the temperature of the inner surface of the preparation tank is very high or very low, the possibility of degradation is higher when the temperature is high, and ice may be formed or local medicines may be precipitated when the temperature is low, so steam and liquid nitrogen are not directly introduced into the jacket heat exchange device. In the traditional process, the heat exchange medium in the jacket heat exchange device is replaced to realize temperature adjustment, that is, hot water is introduced for heating, and then low-temperature medium such as cooling water or glycol solution is injected for cooling. However, in this way, the physical and chemical properties of the heating medium and the cooling medium are quite different, and during the system switching process, medium cross-contamination may occur due to pipeline residues, which directly affects the efficiency of the heat exchange system and poses a risk of drug contamination. In addition, the medium replacement process needs to go through multiple steps of system emptying, cleaning, and refilling, which takes a long time of 10-30 minutes, and cannot meet the process requirement of rapid cooling of heat-sensitive medicines within seconds after dissolution, resulting in continuous exposure of the medicines to a high-temperature environment during the transition period, causing degradation of the active ingredients, reducing the product yield, and possibly causing impurities to exceed the standard and other drug safety hazards. UTILITARY MODEL
[0006] To solve the mutual contamination problem caused by different heating medium and cooling medium in the preparation process of injections in the prior art, and the problem that the medium cannot be replaced quickly to realize rapid cooling and heating, the application provides a medicine preparation tank capable of rapidly reducing and increasing temperature.
[0007] The application is implemented by the following technical scheme:
[0008] A medicine preparation tank capable of rapidly reducing and increasing temperature, comprising a batching tank, a heat exchange device, and a jacket heat exchange device for storing heat exchange medium and heating or cooling the medicine in the batching tank by the heat exchange medium, and the heat exchange device is used for heating or cooling the heat exchange medium flowing between the jacket heat exchange device and the batching tank.
[0009] The quick cooling and heating medicine preparation tank as described above, the jacket heat exchange device comprises a medium storage tank for containing heat exchange medium, and a pipeline set in communication with the medium storage tank, the pipeline set is arranged around the preparation tank and returns to the medium storage tank to form a closed loop.
[0010] The quick cooling and heating medicine preparation tank as described above, the pipeline set comprises a transmission section and a heat exchange section, the heat exchange section is located between the jacket heat exchange device and the preparation tank, and the heat exchange device is arranged corresponding to the heat exchange section.
[0011] The quick cooling and heating medicine preparation tank as described above, the heat exchange device comprises a box body, a heat exchange cavity in the box body for sealing the heat exchange section, a steam valve on the box body in communication with the heat exchange cavity and used for connecting external steam, and a liquid nitrogen valve used for connecting external liquid nitrogen.
[0012] The quick cooling and heating medicine preparation tank as described above, the transmission section is arranged as a main pipeline, and the heat exchange section is arranged as a plurality of parallel arranged branch pipelines.
[0013] The quick cooling and heating medicine preparation tank as described above, a pressure pump is arranged on the transmission section between the medium storage tank and the heat exchange device.
[0014] The quick cooling and heating medicine preparation tank as described above, the steam valve and the liquid nitrogen valve are both opening valves.
[0015] The quick cooling and heating medicine preparation tank as described above, further comprises a thermometer arranged on the preparation tank and used for observing the temperature in the preparation tank.
[0016] The quick cooling and heating medicine preparation tank as described above, a cover opening in communication with the inside of the medium storage tank is arranged on the medium storage tank.
[0017] The quick cooling and heating medicine preparation tank as described above, a driving motor is arranged on the preparation tank, and a stirring rod connected with the output end of the driving motor and arranged in the height direction is arranged in the preparation tank.
[0018] Compared with the prior art, the application has the following advantages:
[0019] The application discloses a medicine preparation tank capable of rapidly reducing and increasing temperature. BRIEF DESCRIPTION OF DRAWINGS
[0021] In order to more clearly illustrate the technical solutions in the embodiments of the application, the drawings needed to be used in the embodiments will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without any creative effort based on these drawings.
[0022] Figure 1 is a three-dimensional view in the embodiments of the application;
[0023] Figure 2 is a top view of Figure 1 ;
[0024] Figure 3 is a sectional view of A-A in Figure 2 ; DETAILED DESCRIPTION
[0026] In order to make the technical problems and beneficial effects of the technical solutions of the application more clear, the application will be further described in detail in combination with the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the application, and are not used to limit the application.
[0027] Please refer to Figures 1 to 3 , a medicine preparation tank capable of rapidly reducing and increasing temperature, comprising a material tank 1, a heat exchange device 2, and a jacket heat exchange device 3 used for storing heat exchange medium and heating or cooling medicine in the material tank 1 by the heat exchange medium, the heat exchange device 2 is used for heating or cooling the heat exchange medium flowing between the jacket heat exchange device 3 and the material tank 1.
[0028] In this embodiment, the heat exchange medium adopts a heat-conducting medium with a wide temperature range, good flowability and low viscosity, such as silicon oil with a viscosity lower than 50, glycerol solution, ethylene glycol solution, etc. The heat exchange medium is directly heated and cooled by the heat exchange device to achieve temperature regulation, without the need to replace the heat exchange medium, thereby avoiding the mutual contamination problem caused by different heating and cooling media in the traditional process and effectively improving the purity and safety of the drug preparation process. Since there is no need to perform complicated medium emptying, cleaning and refilling steps, the cooling time can be greatly reduced to several minutes or even shorter, thereby significantly shortening the temperature regulation time.
[0029] Further, as a preferred embodiment of the present solution but not as a limitation, the jacket heat exchange device 3 comprises a medium storage tank 31 for containing the heat exchange medium, and a pipeline set 32 in communication with the medium storage tank 31, the pipeline set 32 being arranged around the ingredient tank 1 and returning to the medium storage tank 31 to form a closed loop.
[0030] In this embodiment, the heat exchange medium is driven by the pump to flow through the pipeline set 32 to exchange heat with the ingredient tank 1, and then returns to the medium storage tank 31 to complete a cycle. This closed loop design ensures the continuous circulation of the heat exchange medium and the efficient transfer of heat, so that the temperature in the ingredient tank 1 can be quickly and uniformly regulated. Since the heat exchange medium does not need to be replaced during the entire process, the pollution risk caused by medium switching in the traditional process is avoided, thereby improving the purity and safety of drug preparation. In addition, the closed loop design also simplifies the operation process, reduces manual intervention and improves production efficiency.
[0031] Further, as a preferred embodiment of the present solution but not as a limitation, the pipeline set 32 comprises a transmission section 321 and a heat exchange section 322, the heat exchange section 322 being located between the jacket heat exchange device 3 and the ingredient tank 1, and the heat exchange device 2 being arranged corresponding to the heat exchange section 322.
[0032] In this embodiment, by dividing the pipeline set into a transmission section and a heat exchange section and arranging the heat exchange section between the jacket heat exchange device and the ingredient tank, the heat exchange efficiency is significantly improved by closely combining the heat exchange section with the heat exchange device, thereby shortening the heating and cooling time and avoiding the pollution problem caused by medium switching in the traditional process. When the heat exchange medium flows from the transmission section to the heat exchange section, the heat exchange device quickly heats or cools the heat exchange section by steam or liquid nitrogen, so that the medium temperature quickly reaches the target value, and then flows into the jacket heat exchange device to regulate the temperature of the liquid in the ingredient tank, and finally returns to the medium storage tank to form a closed loop cycle. The heat exchange section can be designed in a spiral or coil shape to further increase the heat exchange area, or fins or heat-conducting coatings can be added to the heat exchange section to enhance the heat exchange effect, or a multi-stage temperature control system can be introduced into the heat exchange device to achieve more accurate temperature regulation.
[0033] Further, as a preferred embodiment of the present scheme but not limited, the heat exchange device 2 comprises a box 21, a heat exchange cavity 22 in the box 21 for sealing the heat exchange section 322, and steam valves 23 and liquid nitrogen valves 24 respectively provided on the box 21 and connected to the heat exchange cavity 22 for connecting external steam and liquid nitrogen.
[0034] In the embodiment, when the heat exchange medium flows through the heat exchange section 322, it enters the heat exchange cavity 22 and exchanges heat with steam or liquid nitrogen, thereby achieving heating or cooling. The provision of steam valves 23 and liquid nitrogen valves 24 enables the system to flexibly switch the heat source and cold source as needed, meeting different temperature control requirements.
[0035] Further, as a preferred embodiment of the present scheme but not limited, the transmission section 321 is correspondingly provided as a main pipeline, and the heat exchange section 322 is correspondingly provided as a plurality of parallel branch pipelines.
[0036] In the embodiment, by subdividing the heat exchange section 322 into a plurality of parallel branch pipelines, the contact area between the heat exchange medium and the heat exchange device 2 is increased, thereby significantly improving the heat exchange efficiency. In actual operation, the heat exchange medium enters the plurality of branch pipelines of the heat exchange section 322 from the main pipeline (transmission section 321), exchanges heat with steam or liquid nitrogen in the heat exchange device 2, and then converges back to the main pipeline for continuous circulation. By increasing the number of branch pipelines, the heat exchange area is significantly increased, thereby accelerating the heat exchange speed, meeting the requirements of rapid heating and cooling, achieving more uniform heat distribution, avoiding local overheating or overcooling, and improving the stability and reliability of the system.
[0037] Further, as a preferred embodiment of the present scheme but not limited, a pressure pump 323 is provided on the transmission section 321 between the medium storage tank 31 and the heat exchange device 2.
[0038] In the embodiment, the pressure pump 323 provides additional driving force to ensure that the heat exchange medium can be pumped from the medium storage tank 31 to the heat exchange section at a stable and appropriate flow rate, and then exchanged with the heat exchange device 2. This improves the circulation efficiency of the system, enabling the heat exchange medium to complete the circulation more quickly, thereby accelerating the temperature regulation speed. Secondly, the provision of the pressure pump 323 helps to overcome the resistance in the pipeline, ensuring uniform distribution of the medium in each branch pipeline, and improving the consistency and uniformity of heat exchange. In addition, by adjusting the output pressure of the pressure pump 323, the flow rate of the medium can be flexibly controlled to adapt to different process requirements and heat exchange medium characteristics.
[0039] Further, as a preferred embodiment of the present scheme but not limited, the steam valve 23 and the liquid nitrogen valve 24 are both opening degree valves.
[0040] In this embodiment, the flow rate and pressure of the fluid are controlled by adjusting the opening degree of the valve. In this technology, the steam valve 23 and the liquid nitrogen valve 24 are opening degree valves, which can accurately adjust the flow rate of steam and liquid nitrogen according to the demand of the system, so as to realize precise control of the temperature of the heat exchange medium. Such valves can automatically adjust the opening degree according to the set temperature parameter, ensuring that the system maintains a stable temperature change rate during the heating or cooling process, avoiding excessively high or low temperature.
[0041] Further, as a preferred embodiment of the present scheme but not limited, a thermometer 4 is arranged on the ingredient tank 1 and used to observe the temperature condition in the ingredient tank.
[0042] In this embodiment, the thermometer 4 directly measures the temperature in the ingredient tank 1 and feeds back the data to the control system, so that the system can timely adjust the opening degree of the steam valve 23 and the liquid nitrogen valve 24 according to the deviation between the actual temperature and the set temperature, so as to realize precise adjustment of the temperature. Such real-time temperature monitoring not only improves the response speed of temperature control, but also enhances the adaptive ability of the system, which can better cope with the temperature fluctuations that may occur during the preparation of the drug. In addition, the arrangement of the thermometer 4 also provides intuitive temperature data for the operators, so that they can timely understand and intervene the system operation state, and ensure the smooth progress of the drug preparation process.
[0043] Further, as a preferred embodiment of the present scheme but not limited, a cover opening 311 is arranged on the medium storage tank 31 to communicate the inside of the medium storage tank 31.
[0044] In this embodiment, through the cover opening 311, the operator can conveniently add new heat exchange medium into the medium storage tank 31, or discharge old medium for replacement and maintenance when needed. Such direct physical interface simplifies the operation process of medium management, reduces the system downtime caused by medium replacement or maintenance, and improves the production efficiency. At the same time, the existence of the cover opening 311 also facilitates the inspection and cleaning of the inside of the medium storage tank 31, ensuring the purity of the medium and the normal operation of the system.
[0045] Further, as a preferred embodiment of the present scheme but not limited, a driving motor 5 is arranged on the ingredient tank 1, and a stirring rod 6 is arranged in the ingredient tank 1 and connected with the output end of the driving motor 5 and arranged along the height direction.
[0046] In this embodiment, the driving motor 5 drives the stirring rod 6 through the output end to rotate and stir in the ingredient tank 1, so as to promote the mixing of the medicine solution and various ingredients, thereby accelerating the dissolving process and ensuring the uniformity of the solution. This mechanical stirring not only reduces the time required for medicine preparation, but also helps to avoid the degradation or instability of the medicine caused by local concentration difference.
[0047] Further, as a preferred embodiment of the present application, but not limited, it also includes a control panel electrically connected with the heat exchange device and the ingredient tank respectively.
[0048] The working principle of the present embodiment is as follows:
[0049] When the temperature needs to be raised, the temperature of the control panel is set, the device is started, the steam enters, and the device automatically adjusts the size of the steam valve according to the temperature of the ingredient tank, that is, when the distance from the set temperature is large, the steam valve opening is large, when the set temperature is close to be reached, the steam valve opening becomes small, so as to realize that the temperature is not too high, and when the temperature is reached, the steam valve is automatically closed.
[0050] When the temperature needs to be lowered, the temperature of the control panel is set, the liquid nitrogen valve is opened, and the device automatically adjusts the size of the liquid nitrogen valve according to the temperature of the ingredient tank, that is, when the distance from the set temperature is large, the liquid nitrogen valve opening is large, when the set temperature is close to be reached, the liquid nitrogen valve opening becomes small, so as to realize that the temperature is not too low, and when the temperature is reached, the liquid nitrogen valve is automatically closed.
[0051] When the temperature needs to be maintained, the device can also control the valve opening size of the steam and liquid nitrogen according to the set temperature, so as to realize the temperature maintenance control.
[0052] The above is the embodiment provided in combination with specific content, and it is not intended that the specific implementation of the present application is limited to these descriptions. Any similar structure or method as the present application, or any technical deduction or replacement made on the basis of the concept of the present application, should be considered as the protection scope of the present application.
Claims
1. A rapid cooling and warming pharmaceutical compounding jar comprising, The utility model relates to a medicine preparation tank, which comprises a preparation tank (1), a heat exchange device (2), and a jacket heat exchange device (3) for storing heat exchange medium and heating or cooling medicine in the preparation tank (1) by the heat exchange medium, and the heat exchange device (2) is used for heating or cooling the heat exchange medium flowing between the jacket heat exchange device (3) and the preparation tank (1).
2. The quick cooling and warming medicine dispensing can according to claim 1, characterized in that, The jacket heat exchange device (3) comprises a medium storage tank (31) for containing heat exchange medium, and a pipeline group (32) in communication with the medium storage tank (31), which is arranged around the preparation tank (1) and returns to the medium storage tank (31) to form a closed loop.
3. The quick cooling and warming medicine dispensing can according to claim 2, characterized in that, The pipeline group (32) comprises a transmission section (321) and a heat exchange section (322), the heat exchange section (322) is located between the jacket heat exchange device (3) and the preparation tank (1), and the heat exchange device (2) is arranged corresponding to the heat exchange section (322).
4. The quick cooling and warming medicine dispensing can according to claim 3, characterized in that, The heat exchange device (2) comprises a box body (21), a heat exchange cavity (22) in the box body (21) for sealing the heat exchange section (322), a steam valve (23) on the box body (21) for connecting the heat exchange cavity (22) and externally connecting steam, and a liquid nitrogen valve (24) for externally connecting liquid nitrogen.
5. The quick cooling and warming medicine dispensing can according to claim 3, characterized in that, The transmission section (321) is arranged as a main pipeline, and the heat exchange section (322) is arranged as a plurality of parallel branch pipelines.
6. The quick cooling and warming medicine dispensing can according to claim 3, characterized in that, A pressure pump (323) is arranged between the medium storage tank (31) and the heat exchange device (2) on the transmission section (321).
7. The quick cooling and warming medicine dispensing can according to claim 4, characterized in that, The steam valve (23) and the liquid nitrogen valve (24) are both opening valves.
8. The rapid cooling and warming pharmaceutical compounding jar of claim 1, wherein, A thermometer (4) is arranged on the preparation tank (1) for observing the temperature in the preparation tank.
9. The quick cooling and warming medicine dispensing can according to claim 2, characterized in that, A cover opening (311) is arranged on the medium storage tank (31) for communicating with the inside of the medium storage tank (31).
10. The rapid cooling and warming pharmaceutical compounding jar of claim 1, wherein, A driving motor (5) is arranged on the preparation tank (1), and a stirring rod (6) is arranged in the preparation tank (1) and connected to the output end of the driving motor (5) and arranged along the height direction.