Portable drug transdermal tester

Abstract

The utility model relates to the technical field of medical equipment, and discloses a portable medicine transdermal tester which comprises a machine body, a plurality of diffusion pools and a plurality of medicine feeding openings, second sliding grooves are formed in the left side and the right side of the outer wall of the machine body, and sliding plates are connected to the outer walls of the two second sliding grooves in a sliding mode. A top plate is fixedly connected to the tops of the outer walls of the two sliding plates, a first sliding groove is formed in the top of the outer wall of the top plate, a fixed baffle is fixedly connected to the top of the outer wall of the top plate, a threaded hole is formed in the outer wall of the fixed baffle, and a threaded rod is in threaded connection with the inner wall of the threaded hole. According to the utility model, the threaded rod for fixing the baffle on the top plate is operated to rotate positively and negatively to control the position of the piezoelectric valve in the sliding chute, so that liquid medicine can be squeezed into the liquid storage pipe of the piezoelectric valve in advance according to the air pressure principle, and then the liquid medicine is accurately pressed into the diffusion pool through the dosing port through the piezoelectric valve, thereby avoiding cross contamination of the liquid medicine caused by manual dosing; and the experiment credibility is improved.

Description

Technical Field

[0001] This utility model relates to the field of medical equipment technology, and in particular to a portable transdermal drug testing device. Background Technology

[0002] Drugs are scientifically formulated with a variety of active ingredients and excipients. Common dosage forms include tablets and capsules. They exert their therapeutic effects through specific routes of administration. Their research and development process must strictly adhere to pharmaceutical principles to ensure stability and bioavailability. As a core tool of modern medicine, drug formulations directly affect clinical efficacy and patient safety. Transdermal drug delivery systems require precise assessment of drug penetration efficiency. Transdermal drug testing instruments simulate the skin environment to monitor drug release rates and absorption levels in real time. By combining in vitro experimental data, formulations can be optimized, providing reliable technical support for the development of novel transdermal patches and facilitating precise control of drug quality.

[0003] Traditional transdermal drug transdermal testing devices are based on diffusion cell models. By simulating the skin barrier environment, a semi-permeable membrane separates the donor and recipient chambers, and a constant-temperature water bath is used to maintain physiological temperature. The drug permeates from the donor side to the recipient side through the membrane. After periodic sampling, high-performance liquid chromatography (HPLC) is used to detect concentration changes, thereby assessing the transdermal rate and cumulative release of the drug. The principle relies on passive diffusion and concentration gradient driving. However, in actual use, the above devices rely on manual operation. Fixed sampling intervals lead to the omission of key data, complex steps are prone to human error, and the membrane material may deviate from the actual skin permeability characteristics.

[0004] Existing transdermal drug transdermal testing instruments have improved automation by employing multi-channel parallel diffusion cells, integrating real-time electrochemical sensors to monitor drug concentration, and dynamically adjusting experimental parameters through software. They also enhance simulation accuracy by combining ex vivo skin and biomimetic materials. However, the core process still lacks a standardized machine-based drug delivery structure, requiring manual addition of drugs to the donor side. This process can lead to contact with contaminated samples, interfering with the stability of drug components and reducing the reliability of experimental data. This restricts the efficiency and reproducibility of formulation development. Therefore, a portable transdermal drug transdermal testing instrument is proposed to address these issues. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a portable transdermal drug testing instrument, which aims to improve the problem of low reliability of experimental data caused by drug contamination due to manual drug administration in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a portable transdermal drug testing instrument, comprising a body, a diffusion pool, and a drug delivery port. The outer walls of the body are provided with second sliding grooves on both the left and right sides. Sliding plates are slidably connected to the outer walls of the two second sliding grooves. A top plate is fixedly connected to the top of the outer walls of the two sliding plates. A first sliding groove is provided on the top of the outer wall of the top plate. A fixed baffle is fixedly connected to the top of the outer wall of the top plate. A threaded hole is provided on the outer wall of the fixed baffle. A threaded rod is threadedly connected to the inner wall of the threaded hole. A piezoelectric valve is rotatably connected to the right end of the threaded rod. A guide pipe is connected to the top of the piezoelectric valve. A piston tank is connected to the outer wall of the guide pipe. A water tank is fixedly connected to the top of the outer wall of the body. A temperature uniformity mechanism is provided on the inner wall of the water tank. The temperature uniformity mechanism is used to ensure uniform temperature in all parts of the diffusion pool.

[0007] As a further description of the above technical solution:

[0008] The temperature uniformity mechanism includes a serpentine heating tube, the bottom of the outer wall of the serpentine heating tube is fixedly connected to the top of the inner wall of the water tank, a graphene plate is fixedly connected to the top of the outer wall of the serpentine heating tube, a copper layer is fixedly connected to the inner wall of each of the multiple diffusion pools, a thermally conductive ceramic is fixedly connected to the inner wall of each of the multiple copper layers, and multiple heat insulation rings are fixedly connected to the top of the outer wall of the graphene plate.

[0009] As a further description of the above technical solution:

[0010] A power cord is fixedly connected to the rear side of the outer wall of the machine body. One end of the power cord is fixedly connected to a plug, and the other end of the power cord is fixedly connected to the machine body.

[0011] As a further description of the above technical solution:

[0012] Multiple heat dissipation slots are provided on the left side of the outer wall of the machine body, and the multiple heat dissipation slots are arranged at equal intervals.

[0013] As a further description of the above technical solution:

[0014] A panel base is fixedly connected to the outer wall of the machine body, and multiple displays are fixedly connected to the top of the outer wall of the panel base.

[0015] As a further description of the above technical solution:

[0016] Multiple buttons are fixedly connected to the top of the outer wall of the panel base, and all of the buttons are made of silicone.

[0017] As a further description of the above technical solution:

[0018] Foot pads are fixedly connected to the four corners of the bottom of the outer wall of the machine body, and the surfaces of the multiple foot pads are all rounded.

[0019] As a further description of the above technical solution:

[0020] Multiple indicator lights are fixedly connected to the top of the outer wall of the panel base. These multiple indicator lights are electrically connected to multiple displays, piezoelectric valves, power cords, and plugs, respectively.

[0021] This utility model has the following beneficial effects:

[0022] 1. In this utility model, the piezoelectric valve is positioned in the first slide groove by rotating the threaded rod of the fixed baffle on the top plate in both directions. A piston tank is installed on the right side of the machine body. Using the principle of air pressure, the liquid medicine can be pre-pressed into the storage tube of the piezoelectric valve. Then, the liquid medicine is accurately pressed into the diffusion pool through the administration port by the milliliter-level volume control technology of the piezoelectric valve itself. This avoids cross-contamination of the liquid medicine caused by manual administration and increases the reliability of the experiment.

[0023] 2. In this utility model, multiple curved heating tubes are installed in the water tank to increase the heating area and further conduct heat through the graphene plate, so that the heat is distributed throughout the water tank. Thermally conductive ceramics and copper layers are added to the inner wall of the diffusion pool to improve the temperature uniformity in the diffusion pool. By adding temperature equalization structures in both the water tank and the diffusion pool, experimental errors caused by temperature influence are avoided. Attached Figure Description

[0024] Figure 1 This is a perspective view of a portable transdermal drug testing device proposed in this utility model;

[0025] Figure 2 This is a top view of a portable transdermal drug testing device proposed in this utility model;

[0026] Figure 3 This is a side view of a portable transdermal drug testing device proposed in this utility model;

[0027] Figure 4 This is an exploded view of a portable transdermal drug testing device proposed in this utility model;

[0028] Figure 5 This is a cross-sectional view of the diffusion cell of a portable transdermal drug testing instrument proposed in this utility model.

[0029] Legend:

[0030] 1. Body; 2. Temperature uniformity mechanism; 201. Copper layer; 202. Thermally conductive ceramic; 203. Heat insulation ring; 204. Graphene plate; 205. Snake-shaped heating tube; 3. Slide plate; 4. Top plate; 5. First slide groove; 6. Second slide groove; 7. Fixed baffle; 8. Threaded hole; 9. Threaded rod; 10. Piezoelectric valve; 11. Guide tube; 12. Piston tank; 13. Power cord; 14. Plug; 15. Heat dissipation groove; 16. Panel base; 17. Display screen; 18. Button; 19. Indicator light; 20. Water tank; 21. Foot pad; 22. Diffusion pool; 23. Drug delivery port. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] Reference Figure 1 , Figure 2 and Figure 3This utility model provides an embodiment of a portable transdermal drug delivery tester, comprising a body 1, multiple diffusion cells 22, and multiple drug delivery ports 23. The outer walls of the body 1 are provided with second sliding grooves 6 on both the left and right sides. These second sliding grooves 6 are used to control the relative position of the entire drug delivery structure, facilitating maintenance of the internal diffusion cells 22. Sliding plates 3 are slidably connected to the outer walls of both second sliding grooves 6. The sliding plates 3 are the direct medium for controlling the movement of the structure. Top plates 4 are fixedly connected to the top of the outer walls of the two sliding plates 3. First sliding grooves 5 are provided on the top of the outer walls of the top plates 4. Fixed baffles 7 are fixedly connected to the top of the outer walls of the top plates 4. Threaded holes are provided on the outer walls of the fixed baffles 7. 8. A threaded rod 9 is threadedly connected to the inner wall of the threaded hole 8. A piezoelectric valve 10 is rotatably connected to the right end of the threaded rod 9. The piezoelectric valve 10 is used to precisely control the volume of drug delivery. The top plate 4 is the track for supporting and moving the piezoelectric valve 10. The top of the piezoelectric valve 10 is connected to a guide tube 11, which is the channel for the drug liquid to flow in. The outer wall of the guide tube 11 is connected to a piston tank 12. The piston tank 12 uses an internal piston structure so that when it is pressed down, the drug liquid is squeezed upwards to the storage tube area of ​​the piezoelectric valve 10 due to the air pressure. A water tank 20 is fixedly connected to the top of the outer wall of the body 1. The water tank 20 is the place for water bath heating. The inner wall of the water tank 20 is equipped with A temperature homogenization mechanism 2 is provided to ensure uniform temperature across all parts of the diffusion cell 22. A power cord 13 is fixedly connected to the rear side of the outer wall of the main body 1. One end of the power cord 13 is fixedly connected to a plug 14, and the other end of the power cord 13 is fixedly connected to the outer wall of the main body 1. The power cord 13 enables stable transmission of external power to the instrument. The plug 14 at the end of the power cord 13 serves as a standard power interface, compatible with power grid parameters in different regions. A panel base 16 is fixedly connected to the outer wall of the main body 1, providing a stable support for the control panel, integrating operating components, reducing external vibration interference, and maintaining the horizontal stability of the test platform and the usability of the operating interface. For reliability, multiple displays 17 are fixedly connected to the top of the outer wall of the panel base 16. These displays show key parameter values ​​during device operation and provide clear feedback of test data through a high-contrast interface, providing intuitive and visual support for user operation decisions and device status monitoring. Buttons 18 are fixedly connected to the top of the outer wall of the panel base 16. Buttons 18 are used to control the start and stop of the device. All buttons 18 are made of silicone. Multiple indicator lights 19 are fixedly connected to the top of the outer wall of the panel base 16. The indicator lights 19 show the working status of the device. The multiple indicator lights 19 are electrically connected to the multiple displays 17, piezoelectric valve 10, power cord 13 and plug 14 respectively.

[0033] Specifically, the body 1 has symmetrical second slide grooves 6 on both sides as the reference for adjusting the position of the drug delivery structure. The lateral displacement of the entire device is achieved through the sliding cooperation between the inner wall of the slide groove and the slide plate 3, which facilitates the operator to adjust the maintenance space of the internal diffusion pool 22. The top of the two slide plates 3 is rigidly connected to the top plate 4 as the bearing track of the piezoelectric valve 10. The surface of the top plate 4 is provided with a first slide groove 5 to form a guide path with the fixed baffle 7. The surface of the fixed baffle 7 is provided with a threaded hole 8 and a threaded rod 9 to form a transmission pair with the piezoelectric valve 10. When the threaded rod 9 rotates, it drives the piezoelectric valve 10 to move precisely along the first slide groove 5. The connection between the threaded rod 9 and the piezoelectric valve 10 is made of a hidden rotating structure to ensure that the rotation of the threaded rod 9 will not affect the normal movement of the piezoelectric valve 10, so as to achieve micro-level drug volume control. The front end of the piezoelectric valve 10 is connected to the guide pipe 11 as the drug input channel. The end of the guide pipe 11 is connected to the piston tank 12. The negative pressure effect generated by the piston pressing down is used to quantitatively deliver the drug to the storage area of ​​the piezoelectric valve 10 through the guide pipe 11. The top-mounted water tank 20 serves as a constant-temperature water bath container, with an integrated temperature uniformity mechanism 2 inside. Through fluid circulation or heat conduction elements, it ensures a balanced temperature distribution in all areas of the diffusion pool 22. The power cord 13 connected to the rear of the unit 1 serves as an energy input channel. The end of the power cord 13 is equipped with a plug 14 to adapt to different power socket specifications, meeting the electrical safety standards of multiple regions. The panel base 16 serves as the core area for human-machine interaction. Multiple displays 17 are installed on its top to display key data such as temperature parameters, pressure values, and flow curves in real time. The grayscale interface optimizes visual recognition. The adjacent buttons 18 are made of silicone to enhance the tactile feel of operation. The array of buttons 18 works in conjunction with the indicator lights 19. The indicator lights 19 use color coding to indicate the opening and closing status of the piezoelectric valve 10, the power supply status of the power cord 13, and the connection status of the plug 14, realizing visualized monitoring of the entire equipment operation process. All electronic units and mechanical components form a closed-loop control system through internal cables, ensuring that the drug delivery accuracy and temperature stability meet the requirements of the drug transdermal testing standards.

[0034] Reference Figure 1 , Figure 4 and Figure 5The temperature uniformity mechanism 2 includes a serpentine heating tube 205. The serpentine heating tube 205 has a multi-bending structure to increase the actual heating area. The bottom of the outer wall of the serpentine heating tube 205 is fixedly connected to the top of the inner wall of the water tank 20. A graphene plate 204 is fixedly connected to the top of the outer wall of the serpentine heating tube 205. The graphene plate 204 plays a certain role in heat conduction. A copper layer 201 is fixedly connected to the inner wall of multiple diffusion pools 22. The copper layer 201 is used to better conduct heat. A thermally conductive ceramic 202 is fixedly connected to the inner wall of the copper layer 201. It uniformly transfers heat through high thermal conductivity, maintains the consistency of temperature distribution in the pool, ensures the stability of the drug penetration experimental environment, reduces the interference of thermal gradient on diffusion rate, and improves the accuracy and repeatability of test data. Multiple heat insulation rings 203 are fixedly connected to the top of the outer wall of the graphene plate 204. They are used to isolate the relatively low temperature from outside the ring to a certain extent.

[0035] Specifically, the snake-shaped heating tube 205 adopts a multi-segment bending design to expand the effective heating area. Its bottom is rigidly connected to the top of the inner wall of the water tank 20. The top plane integrates a graphene plate 204 as a high thermal conductivity medium to accelerate the lateral diffusion of heat. The inner wall of the diffusion pool 22 is covered with a copper layer 201 to improve the overall thermal conductivity. The surface of the copper layer 201 is composite with thermally conductive ceramic 202 to construct a double-layer heat conduction system. With the help of the high thermal conductivity of the ceramic material, heat is evenly distributed, eliminating local temperature differences in the pool, maintaining the thermodynamic balance of the drug penetration experimental environment, suppressing diffusion rate fluctuations caused by thermal gradients, and ensuring the accuracy of experimental data and the reproducibility of results across batches. A heat insulation ring 203 is installed around the top edge of the graphene plate 204. The low thermal conductivity material blocks the heat radiation dissipation of the core heating area from the low temperature of the external environment, forming a directional heat insulation barrier, reducing energy loss, optimizing the energy efficiency ratio of the temperature control system, and achieving precise control of the internal temperature field of the diffusion pool 22.

[0036] Reference Figure 1 and Figure 3 Multiple heat dissipation slots 15 are provided on the left side of the outer wall of the body 1. The heat dissipation slots 15 are used to dissipate heat from the device to prevent it from being affected by excessive heat. The multiple heat dissipation slots 15 are arranged at equal intervals. Foot pads 21 are fixedly connected to the four corners of the bottom of the outer wall of the body 1. The surface of the multiple foot pads 21 is rounded. The elastic material of the foot pads buffers the vibration of the device during operation and increases the friction with the contact surface to prevent displacement.

[0037] Specifically, multiple heat dissipation slots 15 are opened on the outer left side of the body 1 for the directional discharge of heat during equipment operation. The internal component temperature is reduced by air convection to avoid performance degradation or component damage caused by overheating. The heat dissipation slots 15 are arranged with uniform spacing to ensure a balance between heat dissipation efficiency and structural strength. Foot pads 21 are fixedly installed at the four corners of the bottom of the body 1. The surface of the foot pads 21 is polished with an arc surface and filled with a high-elasticity material to absorb mechanical vibration energy, increase the friction coefficient of the bottom contact surface, and suppress the tendency of the equipment to displace due to vibration. The foot pads 21 adjust the horizontal orientation of the base through elastic deformation to maintain the overall structural stability of the instrument, reduce the impact of external environmental vibration on the test accuracy, and ensure the reliability of the data acquisition process and the long-term operating life of the equipment.

[0038] Working principle: First, the relative position of the screw rod 9 of the fixed baffle 7 on the rotating top plate 4 with the piezoelectric valve 10 is adjusted. The forward and reverse rotation of the screw rod 9 drives the piezoelectric valve 10 to make linear displacement along the first slide groove 5, accurately positioning the docking coordinates of the drug inlet 23 and the diffusion pool 22. The piston tank 12 installed on the right side of the body 1 compresses the internal air to form a negative pressure by the downward movement of the piston, drawing the external drug solution into the storage tube through the guide tube 11 for temporary storage. The piezoelectric valve 10 integrates a milliliter-level volume control module, which precisely controls the release volume of the drug solution based on the linear relationship between the deformation of the piezoelectric ceramic and the voltage signal. When the piezoelectric valve 10 moves to the target position, the piezoelectric ceramic deforms under control, squeezing the liquid storage tube. The drug solution is injected into the diffusion pool 22 through the drug delivery port 23 with micro-level precision. This process eliminates the risk of contact contamination in manual liquid handling through the synergistic effect of mechanical transmission and electronic control technology, and avoids cross-contamination caused by drug residues from different batches. At the same time, the closed-loop feedback system of the piezoelectric valve 10 calibrates the dosage in real time, ensuring that the drug input error in each experiment is lower than the instrument design threshold, significantly improving the data consistency of transdermal drug penetration test, and providing reliable technical support for cross-batch experimental result comparison.

[0039] Furthermore, the water tank 20 integrates a serpentine heating tube 205, whose multi-segment bending design significantly expands the effective heating area. Combined with the top high thermal conductivity graphene plate 204, this accelerates lateral heat diffusion, achieving uniform temperature distribution throughout the water tank 20. The inner wall of the diffusion pool 22 features a composite copper layer 201 as a base heat-conducting layer. The surface of the copper layer 201 is covered with thermally conductive ceramic 202 to create an efficient heat conduction interface. The high thermal conductivity of the ceramic material evenly transfers heat to all areas of the diffusion pool 22, eliminating localized temperature differences within the pool. The water tank 20 and the diffusion pool 22 operate collaboratively through a dual-level temperature uniformity mechanism 2. The heat generated by the serpentine heating tube 205 is rapidly conducted to the water in the water tank 20 via the graphene plate 204. The composite structure formed by layer 201 and thermally conductive ceramic 202 further optimizes the thermal field uniformity inside the diffusion pool 22. This design suppresses the formation of temperature gradients through a dual thermal management mechanism, avoiding deviations in drug penetration rate measurement due to uneven heat distribution. A heat insulation ring 203 is added to the edge of the graphene plate 204 to block external low-temperature interference. The combination of copper layer 201 and thermally conductive ceramic 202 ensures that heat is uniformly released along the axial direction of the diffusion pool 22, reducing experimental errors caused by edge effects. Through the synergistic effect of the water tank 20 and the dual-level temperature uniformity mechanism 2 of the diffusion pool 22, the temperature fluctuation throughout the experiment is controlled within the preset threshold, ensuring the accuracy of drug transdermal test data and the reproducibility of results across batches.

[0040] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A portable drug transdermal testing apparatus comprising a body (1), a plurality of diffusion cells (22) and a plurality of administration ports (23), characterised in that: The outer wall of the body (1) is provided with a second sliding groove (6) on the left and right sides, the outer wall of the two second sliding grooves (6) is slidably connected with a sliding plate (3), the outer wall top of the two sliding plates (3) is fixedly connected with a top plate (4), the outer wall top of the top plate (4) is provided with a first sliding groove (5), the outer wall top of the top plate (4) is fixedly connected with a fixed baffle (7), the outer wall of the fixed baffle (7) is provided with a threaded hole (8), the inner wall of the threaded hole (8) is threadedly connected with a threaded rod (9), the right end of the threaded rod (9) is rotatably connected with a piezoelectric valve (10), the top end of the piezoelectric valve (10) is communicated with a flow guide pipe (11), the outer wall of the flow guide pipe (11) is communicated with a piston tank (12), the outer wall top of the body (1) is fixedly connected with a water tank (20), the inner wall of the water tank (20) is provided with a temperature uniform mechanism (2), and the temperature uniform mechanism (2) is used to make the temperature of each part of the diffusion tank (22) uniform.

2. The portable drug transdermal test apparatus according to claim 1, wherein: The temperature uniform mechanism (2) comprises a snake-shaped heating pipe (205), the outer wall bottom of the snake-shaped heating pipe (205) is fixedly connected to the inner wall top of the water tank (20), the outer wall top of the snake-shaped heating pipe (205) is fixedly connected with a graphene plate (204), the inner wall of each of a plurality of diffusion tanks (22) is fixedly connected with a copper layer (201), the inner wall of each of a plurality of copper layers (201) is fixedly connected with a heat-conducting ceramic (202), and the outer wall top of the graphene plate (204) is fixedly connected with a plurality of heat insulation rings (203).

3. The portable drug transdermal test meter of claim 1, wherein: The outer wall rear side of the body (1) is fixedly connected with a power line (13), one end of the power line (13) is fixedly connected with a plug (14), and the other end of the power line (13) is fixedly connected to the body (1).

4. The portable drug transdermal test meter of claim 1, wherein: The outer wall left side of the body (1) is provided with a plurality of heat dissipation grooves (15), and the plurality of heat dissipation grooves (15) are arranged at equal intervals.

5. The portable drug transdermal test meter of claim 1, wherein: The outer wall of the body (1) is fixedly connected with a panel base (16), and the outer wall top of the panel base (16) is fixedly connected with a plurality of display screens (17).

6. The portable drug transdermal test meter of claim 5, wherein: The outer wall top of the panel base (16) is fixedly connected with a plurality of buttons (18), and the plurality of buttons (18) are all made of silica gel material.

7. The portable drug transdermal test meter of claim 1, wherein: The outer wall bottom of the body (1) is fixedly connected with a plurality of foot pads (21) at four corners, and the surfaces of the plurality of foot pads (21) are all rounded.

8. The portable drug transdermal test meter of claim 6, wherein: The outer wall top of the panel base (16) is fixedly connected with a plurality of indicator lights (19), and the plurality of indicator lights (19) are respectively electrically connected with the plurality of display screens (17), the piezoelectric valve (10), the power line (13) and the plug (14).

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