Dissolver for promoting mixing of drug-loaded microspheres

Abstract

The utility model relates to the field of drug-loaded microsphere mixing dissolvers, and discloses a drug-loaded microsphere mixing promoting dissolver which comprises a base, a supporting plate is fixed in the base, and a driving motor is installed on the inner wall between the supporting plate and the base. An output shaft of the driving motor penetrates through the supporting plate and is connected with the center of a cylindrical rotating frame to drive the rotating frame to rotate; a plurality of evenly-distributed rotating cylinders are arranged in the rotating frame around the center of the rotating frame, and the rotating cylinders are in rotating fit with the rotating frame. According to the utility model, through the meshing of the gear and the gear ring, when the rotating frame drives the rotating cylinder to revolve, the rotating cylinder can realize autorotation, so that the storage tube filled with the drug-loaded microspheres and the solvent in the placing groove generates a complex motion trail, and the drug-loaded microspheres are promoted to be fully mixed in the solvent; the problem of stirring dead angles existing in traditional one-way stirring is effectively avoided, and the mixing efficiency is greatly improved.

Description

Technical Field

[0001] This utility model relates to the field of drug-loaded microsphere mixing and dissolving devices, and more particularly to a device for promoting the mixing and dissolving of drug-loaded microspheres. Background Technology

[0002] Drug-loaded microspheres, as a novel drug carrier, play a vital role in modern medicine, especially in interventional therapy. They encapsulate or adsorb drugs within tiny carrier particles, which are typically made of biodegradable materials. This enables the slow release of drugs, prolongs their duration of action in the body, and improves their efficacy. Furthermore, by modifying the surface of the microspheres, they can be made to be targeted, precisely delivering drugs to the lesion site and reducing toxic side effects on normal tissues.

[0003] However, before using drug-loaded microspheres for treatment, they need to be mixed and dissolved with a specific solvent to ensure that the drug-loaded microspheres can be uniformly dispersed in the solution, thus ensuring the consistency and stability of drug release. Mechanical stirring is usually used for mixing.

[0004] Traditional stirring equipment typically only stirs in one direction during operation. In unidirectional stirring, the fluid flow in the solution is relatively uniform, making it difficult for drug-loaded microspheres to be dispersed evenly and comprehensively in the solution. Drug-loaded microspheres near the stirring paddle receive higher shear forces, while those far from the stirring paddle experience less force, reducing mixing efficiency. To address this issue, a drug-loaded microsphere mixing and dissolving device is proposed. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a drug-loaded microsphere mixing and dissolving device, which aims to solve the problem in the prior art that "traditional stirring equipment stirs in one direction during operation, resulting in dead zones and reduced mixing efficiency".

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a device for promoting the mixing and dissolution of drug-loaded microspheres, comprising a base, a support plate fixed inside the base, a drive motor installed on the inner wall between the support plate and the base, and the output shaft of the drive motor passing through the support plate and connected to the center of a cylindrical rotating frame, thereby driving the rotating frame to rotate; a plurality of evenly distributed rotating cylinders are arranged around the center of the rotating frame, and the rotating cylinders are rotatably engaged with the rotating frame; a gear ring is arranged on the inner wall of the support plate, and a gear meshing with the gear ring is fixed at the bottom of the rotating cylinder;

[0007] The rotating cylinder has multiple slots for placing storage tubes, and the storage tubes contain drug-loaded microspheres and solvents.

[0008] As a further description of the above technical solution:

[0009] The rotating frame and the rotating cylinder are rotatably coupled via bearings.

[0010] As a further description of the above technical solution:

[0011] The rotating cylinder is equipped with a fixing component for securing the storage tube.

[0012] As a further description of the above technical solution:

[0013] The fixing assembly includes a central groove disposed at the center of the rotating cylinder; a plurality of placement grooves are evenly distributed around the central groove; an operating rod is disposed in the central groove, and an extrusion block is disposed outside the lower part of the operating rod. The extrusion block is in the shape of a frustum that gradually narrows from top to bottom. A moving block is slidably connected to the inner wall of the placement groove, and the inner end of the moving block is an inclined surface that fits against the extrusion block, and an extrusion component located in the placement groove is fixed at the outer end.

[0014] As a further description of the above technical solution:

[0015] A return spring is arranged between the outer end face of the inclined surface of the moving block and the inner wall end face of the placement groove.

[0016] As a further description of the above technical solution:

[0017] The upper part of the operating lever is threaded into the inner wall of the rotating cylinder.

[0018] As a further description of the above technical solution:

[0019] The extrusion component is made of rubber.

[0020] This utility model has the following beneficial effects:

[0021] 1. In this utility model, through the meshing of gears and gear rings, while the rotating frame drives the rotating cylinder to revolve, the rotating cylinder can also rotate on its own axis. This causes the storage tube containing drug-loaded microspheres and solvent in the placement tank to generate a complex motion trajectory, which promotes the full mixing of drug-loaded microspheres in the solvent, effectively avoids the problem of dead zones in traditional unidirectional stirring, and greatly improves the mixing efficiency.

[0022] 2. In this utility model, a fixed component is provided inside the moving cylinder. When the operating rod is rotated, the threaded engagement between the operating rod and the inner wall of the rotating cylinder drives the extrusion block to move downward. The extrusion block drives the moving block that is in contact with it to slide on the inner wall of the placement groove, thereby driving the extrusion component to extrude and fix the storage tube. At the same time, the extrusion component is made of rubber, which uses its friction to further stabilize the storage tube, ensuring that the storage tube will not shake or shift during the mixing process, thus ensuring the stability and safety of the mixing process. Attached Figure Description

[0023] Figure 1 This is a three-dimensional structural diagram of the overall device in this utility model;

[0024] Figure 2 This is a three-dimensional structural diagram of the disassembled, bottom-view view of the overall device in this utility model;

[0025] Figure 3 This is a three-dimensional structural diagram of the disassembled rotating frame and rotating cylinder in this utility model;

[0026] Figure 4 This is a front-view three-dimensional cross-sectional view of the rotating cylinder in this utility model;

[0027] Legend:

[0028] 1. Base; 2. Drive motor; 3. Support plate; 4. Rotating frame; 51. Bearing; 52. Rotating cylinder; 53. Gear; 54. Gear ring; 55. Placement slot; 56. Operating lever; 57. Extrusion block; 58. Moving block; 59. Extrusion component; 6. Return spring. Detailed Implementation

[0029] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0030] Reference Figure 1 - Figure 3This utility model provides an embodiment of a drug-loaded microsphere mixing and dissolving device, comprising a base 1 for supporting a drive motor 2 and a support plate 3. The support plate 3 is fixed inside the base 1, and the drive motor 2 is installed on the inner wall between the support plate 3 and the base 1. The output shaft of the drive motor 2 drives a rotating frame 4 to rotate, providing power support for mixing the drug-loaded microspheres. The output shaft of the drive motor 2 passes through the support plate 3 and is connected to the center of the cylindrical rotating frame 4, driving the rotating frame 4 to rotate. The rotating frame 4 supports multiple sets of rotating cylinders 52, driving the multiple sets of rotating cylinders 52 to rotate. Multiple evenly distributed rotating cylinders 52 are arranged around the center of the rotating frame 4, driving multiple sets of drug-loaded microspheres to rotate. The storage tubes for microspheres and solvents rotate, and the rotating cylinder 52 is rotatably engaged with the rotating frame 4. The rotating frame 4 and the rotating cylinder 52 are rotatably engaged through the bearing 51. The bearing 51 connects the rotating frame 4 and the rotating cylinder 52, allowing the rotating cylinder 52 to rotate freely relative to the rotating frame 4, ensuring the smooth operation of the rotating cylinder 52 during the mixing process. The inner wall of the support plate 3 is provided with a gear ring 54, and the bottom of the rotating cylinder 52 is fixed with a gear 53 that meshes with the gear ring 54. When the rotating frame 4 rotates, it drives the rotating cylinder 52 to revolve around the output shaft of the drive motor 2. At the same time, the meshing of the gear 53 and the gear ring 54 causes the rotating cylinder 52 to rotate, causing the storage tube in the placement groove 55 to produce complex movements, promoting the mixing of drug-loaded microspheres.

[0031] Reference Figure 2 - Figure 4 The rotating cylinder 52 has multiple placement slots 55 for placing storage tubes, and the storage tubes contain drug-loaded microspheres and solvents. An operating rod 56 is provided on the inner wall of the rotating cylinder 52. By operating the operating rod 56, the position of the extrusion block 57 can be controlled, thereby controlling the position of the moving block 58 and the extrusion piece 59, so as to realize the fixing and loosening operation of the storage tube.

[0032] A fixing assembly for securing the storage tube is installed inside the rotating cylinder 52. The fixing assembly includes a central groove located at the center of the rotating cylinder 52; multiple placement slots 55 are evenly distributed around the central groove; an operating rod 56 is installed inside the central groove, and a pressing block 57 is installed outside the lower part of the operating rod 56. The pressing block 57 is a frustum-shaped cone that tapers from top to bottom. The upper part of the operating rod 56 is threaded into the inner wall of the rotating cylinder 52. A moving block 58 is slidably connected to the inner wall of the placement slot 55, and the inner end of the moving block 58 is an inclined surface that fits against the pressing block 57. The moving block 58 moves under the action of the pressing block 57, realizing the pressing and fixing action of the pressing component 59 on the storage tube, and can be reset under the action of the return spring 6. An extrusion member 59 is fixed at the outer end of the container and located in the placement groove 55. The extrusion member 59 is made of rubber and slides on the inner wall of the placement groove 55, directly contacting the storage tube. Using the friction of the rubber, the storage tube is stably fixed under the action of the moving block 58, preventing the storage tube from shaking or shifting during the mixing process. A return spring 6 is arranged between the outer end face of the inclined surface of the moving block 58 and the end face of the inner wall of the placement groove 55. One end of the return spring 6 is fixedly connected to the outside of the moving block 58, and the other end of the return spring 6 is fixedly connected to the inner wall of the rotating cylinder 52, providing elastic force to the moving block 58. When the fixation of the storage tube is released, the moving block 58 and the extrusion member 59 can be reset.

[0033] Working principle: When in use, the drive motor 2 is turned on, and its output shaft drives the rotating frame 4 to rotate. When the rotating frame 4 rotates, the rotating cylinder 52 installed in it revolves around the output shaft of the drive motor 2. At the same time, the gear 53 at the bottom of the rotating cylinder 52 meshes with the gear ring 54 fixed on the upper part of the support plate 3, causing the rotating cylinder 52 to rotate on its own axis. The storage tube containing the drug-loaded microspheres and solvent is placed in the placement groove 55 on the rotating cylinder 52. The combined motion of revolution and rotation causes the storage tube to generate a complex trajectory, which promotes the full mixing of the drug-loaded microspheres in the solvent and improves the mixing efficiency.

[0034] After placing the storage tube, rotate the operating lever 56. The upper part of the operating lever 56 is threaded into the inner wall of the rotating cylinder 52, causing the extrusion block 57 to move downward. Since the inclined surface on the lower outer side of the extrusion block 57 slides into the inclined surface on the outer side of the moving block 58, the moving block 58 and the extrusion piece 59 slide on the inner wall of the rotating cylinder 52, thus extruding and fixing the storage tube in the placement groove 55 to prevent it from shaking or shifting during the mixing process.

[0035] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A drug-loaded microsphere facilitated mixed dissolver, characterized in that, The application relates to a medicine storage and mixing device, which comprises a base (1), a support plate (3) fixed in the base (1), a driving motor (2) installed between the support plate (3) and the base (1), an output shaft of the driving motor (2) penetrating through the support plate (3) and being connected with the center of a rotating frame (4) in a cylindrical shape to drive the rotating frame (4) to rotate, a plurality of rotating cylinders (52) uniformly distributed around the center of the rotating frame (4) and being in rotating cooperation with the rotating frame (4), a gear ring (54) arranged on the inner wall of the support plate (3), and a gear (53) fixed at the bottom of the rotating cylinder (52) and being in mesh with the gear ring (54). The rotating cylinder (52) is provided with a plurality of placing grooves (55) for placing storage tubes, and the storage tubes store medicine microspheres and solvents.

2. The drug-loaded microspheres promoting mixed dissolver according to claim 1, characterized in that: The rotating frame (4) and the rotating cylinder (52) are in rotating cooperation through a bearing (51).

3. The drug-loaded microspheres dissolution-promoting mixing device according to claim 1, characterized in that: The rotating cylinder (52) is provided with a fixing assembly for fixing the storage tubes.

4. The facilitated drug-loaded microspheres mixed dissolver according to claim 3, characterized in that: The fixing assembly comprises a center groove arranged at the center of the rotating cylinder (52), a plurality of the placing grooves (55) uniformly distributed around the center groove, an operating rod (56) arranged in the center groove, an extrusion block (57) arranged at the lower part of the operating rod (56) and in a circular truncated cone shape tapering from top to bottom, a moving block (58) slidably connected to the inner wall of the placing groove (55), and an extrusion piece (59) fixed to the inner end of the moving block (58) and located in the placing groove (55).

5. The facilitated drug-loaded microspheres mixed dissolver according to claim 4, characterized in that: A reset spring (6) is arranged between the outer end surface of the inclined surface of the moving block (58) and the inner wall end surface of the placing groove (55).

6. The facilitated drug-loaded microspheres mixed dissolver according to claim 4, characterized in that: The upper part of the operating rod (56) is in screw cooperation with the inner wall of the rotating cylinder (52).

7. The facilitated drug-loaded microspheres mixed dissolver according to claim 4, characterized in that: The extrusion piece (59) is made of rubber.

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