Column oven of liquid chromatographic column

Abstract

The utility model belongs to the technical field of liquid chromatograph temperature control, and provides a liquid chromatographic column oven. The liquid chromatographic column oven comprises: an oven body provided with a first heating chamber and a second heating chamber; the air heating device is arranged in the first heating cavity and is suitable for heating the heating cavity; and the liquid heating device is arranged in the second heating cavity, a liquid pipeline is wound on the outer surface of the liquid heating device, and the liquid heating device is suitable for heating the liquid pipeline. Air and liquid are heated at the same time through the air heating device and the liquid heating device, the heating time is shortened, the heating efficiency is improved, and power consumption is reduced.

Description

TECHNICAL FIELD

[0001] The utility model belongs to liquid chromatograph temperature control technical field, concretely relates to a liquid chromatographic column oven. BACKGROUND

[0002] The column oven is an important auxiliary equipment indispensable in analytical instruments such as liquid chromatography (HPLC) and gas chromatography (GC), which is used for accurately controlling the temperature of the chromatographic column, thereby improving the stability and repeatability of analysis.

[0003] In the related art, the column oven is through heating air, heating air again after heat conduction to the chromatographic column again heat conduction to the internal liquid, and the efficiency is too low, and the heating speed is slow, the power consumption is high, and the efficiency is low. SUMMARY

[0004] Therefore, the utility model provides a liquid chromatographic column oven to solve the problem of slow heating speed, high power consumption and low efficiency of the column oven in the prior art.

[0005] The utility model provides a liquid chromatographic column oven, which comprises a box body provided with a first heating cavity and a second heating cavity, an air heating device arranged in the first heating cavity and adapted to heat the heating cavity, and a liquid heating device arranged in the second heating cavity, wherein the outer surface of the liquid heating device is wound with a liquid pipeline, and the liquid heating device is adapted to heat the liquid pipeline.

[0006] In an optional embodiment, the liquid heating device has a columnar structure, and the outer surface of the columnar structure is sequentially provided with a plurality of annular grooves in the height direction of the columnar structure to accommodate the liquid pipeline.

[0007] In an optional embodiment, the annular grooves are arranged in a spiral shape.

[0008] In an optional embodiment, the air heating device comprises a mounting frame formed with a mounting space, and two heating sheet groups oppositely and spacedly arranged in the mounting space.

[0009] In an optional embodiment, the air heating device further comprises a fan arranged in the mounting space, wherein the upper end of the mounting frame is provided with an air inlet, and the lower part of the mounting frame is provided with an air outlet.

[0010] In an optional embodiment, the liquid chromatographic column oven further comprises an adjustable lock buckle having an adjustable avoiding space for the chromatographic column of different diameters to penetrate, and a plurality of mounting positions sequentially arranged on the mounting frame in the height direction of the mounting frame, and the threaded hole of the adjustable lock buckle is connected with the mounting position through a fastener.

[0011] In an alternative embodiment, the liquid chromatographic column oven further comprises: a temperature detection assembly adapted to detect the heating temperature of the heating cavity; an alarm module arranged on the heating circuit; and an electric control device electrically connected to the temperature detection assembly and the alarm module respectively, so as to control the alarm module to send an alarm signal and cut off the power supply of the heating circuit when the heating temperature reaches a preset temperature.

[0012] In an alternative embodiment, the electric control device comprises a safety circuit, which comprises: an alternating current power loop provided with a circuit breaker, the allowable current of the circuit breaker being 6 amperes; a power socket arranged on the alternating current power loop; an indicator lamp arranged on the alternating current power loop between the power socket and the circuit breaker; and a relay connected to the alternating current power loop.

[0013] In an alternative embodiment, the liquid chromatographic column oven further comprises: a liquid leakage sensor arranged at the bottom of the first heating cavity, the liquid leakage sensor being communicatively connected to the electric control device and the alarm module, and if the data detected by the liquid leakage sensor exceeds a preset value, the alarm module is triggered to send an alarm signal and / or cut off the power supply.

[0014] The beneficial effects of the present application are as follows:

[0015] 1. The air heating device and the liquid heating device are used to simultaneously heat air and liquid, thereby shortening the heating time.

[0016] 2. The temperature detection assembly, the alarm module and the electric control device are used to send alarm information to an upper computer and cut off the total power supply.

[0017] 3. The adjustable lock buckle is used to adapt to chromatographic columns of different diameters and heights, and is compatible with 90% of chromatographic columns on the market.

[0018] 4. The fan is arranged in the air heating device, the air inlet is arranged at the upper end of the mounting bracket, and the air outlet is arranged below the mounting bracket, so that the temperature control precision is high and the fluctuation is small, the internal circulation heating is efficient and low in energy consumption, and since the box body does not have air inlets and outlets, the use environment is not required. BRIEF DESCRIPTION OF DRAWINGS

[0019] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the following will briefly introduce the drawings needed to be used in the specific embodiments or the prior art description. Obviously, the drawings described below are some embodiments of the present application, and those skilled in the art can obtain other drawings according to these drawings without creative labor.

[0020] Figure 1 It is the stereogram structure schematic view of the liquid chromatographic column oven of one embodiment of the utility model;

[0021] Figure 2 It is the stereogram structure schematic view of the liquid heating device of the liquid chromatographic column oven of one embodiment of the utility model;

[0022] Figure 3 It is the stereogram structure schematic view of the air heating device of the liquid chromatographic column oven of one embodiment of the utility model;

[0023] Figure 4 It is the stereogram structure schematic view of the liquid chromatographic column oven of another embodiment of the utility model;

[0024] Figure 5 It is the front view structure schematic view of the liquid chromatographic column oven of one embodiment of the utility model;

[0025] Figure 6 It is the structure diagram of the safety circuit of the liquid chromatographic column oven of one embodiment of the utility model.

[0026] Explanation of reference signs:

[0027] 1, box body;2, air heating device;21, heating sheet group;22, air inlet;23, air outlet;3, liquid heating device;4, adjustable lock buckle;5, liquid leakage sensor;6, display screen;7, chromatographic column;8, electric control device;9, liquid leakage tray;10, liquid pipeline;11, indicator lamp;12, power socket;13, circuit breaker;14, relay. Specific implementation

[0028] In order to make the purpose, technical scheme and advantage of the embodiment of the utility model more clear, the technical scheme in the embodiment of the utility model will be described clearly and completely below by combining with the drawings in the embodiment of the utility model, obviously, the described embodiment is a part of the embodiment of the utility model, rather than all the embodiment. Based on the embodiment in the utility model, all other embodiments obtained by the person skilled in the art without making creative labor are within the protection scope of the utility model.

[0029] In the description of the utility model, it needs to explain, the term "center", "upper", "lower", "left", "right", "vertical", "horizontal", "internal", "external" and so on indicate the orientation or position relation based on the orientation or position relation shown in the drawing, only for the convenience of describing the utility model and simplifying the description, and not indicate or imply that the indicated device or element must have a particular orientation, construct and operate in a particular orientation, therefore, it cannot be understood as a limitation on the utility model. In addition, the terms "first", "second", "third" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0030] In the description of the utility model, it needs to explain, the term "center", "upper", "lower", "left", "right", "vertical", "horizontal", "internal", "external" and so on indicate the orientation or position relation based on the orientation or position relation shown in the drawing, only for the convenience of describing the utility model and simplifying the description, and not indicate or imply that the indicated device or element must have a particular orientation, construct and operate in a particular orientation, therefore, it cannot be understood as a limitation on the utility model. In addition, the terms "first", "second", "third" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0031] In addition, the technical features involved in the different embodiments of the utility model described below can be combined with each other as long as there is no conflict.

[0032] The embodiments of the utility model are described below in combination with Figures 1 to 6 .

[0033] As Figure 1 shown, according to the embodiments of the utility model, a liquid chromatographic column 7 oven is provided, the liquid chromatographic column 7 oven comprises: a box body 1, which is provided with a first heating cavity and a second heating cavity;An air heating device 2 is arranged in the first heating cavity and is suitable for heating the heating cavity;A liquid heating device 3 is arranged in the second heating cavity, and the outer surface of the liquid heating device 3 is wound with a liquid pipeline 10, and the liquid heating device 3 is suitable for heating the liquid pipeline 10.

[0034] The first heating cavity and the second heating cavity are respectively a sealed space with good heat preservation performance. The first heating cavity is mainly used for accommodating the air heating device 2 to provide a stable temperature environment for the chromatographic column 7, which can ensure that the heated air is uniformly distributed, and avoid the influence of local temperature difference on the performance of the chromatographic column 7. The second heating cavity is used for installing the liquid heating device 3, which is used for heating the mobile phase liquid pipeline 10, which can ensure that the liquid is uniformly heated in the pipeline, and avoid the deformation of chromatographic peak or the decrease of separation degree caused by temperature difference.

[0035] The air heating device 2 is installed in the first heating cavity to heat the air in the heating cavity. By heating the air, a uniform and stable temperature environment is provided for the chromatographic column 7, and the temperature in the heating cavity is ensured to be always within the preset range. The liquid heating device 3 is installed in the second heating cavity, and the outer surface of the liquid heating device 3 is wound with the liquid pipeline 10 for conveying the mobile phase of liquid chromatography or other related liquid. The liquid heating device 3 heats the liquid pipeline 10 wound on the surface thereof, and ensures that the mobile phase reaches the required temperature before entering the chromatographic column 7. The device transmits heat to the liquid pipeline 10 through an electric heating element, so that the mobile phase can be uniformly heated. The heating efficiency is high and the temperature control precision is high, which can effectively avoid analysis errors caused by temperature changes of the mobile phase.

[0036] The box body 1 is externally provided with an operation panel and a display screen 6 for setting and displaying temperature parameters, which facilitates accurate control by the user.

[0037] In this example, the air heating device 2 heats the air in the first heating cavity to form a stable temperature environment to meet the temperature requirements of the chromatographic column 7. At the same time, the liquid heating device 3 heats the liquid pipeline 10 in the second heating cavity to ensure that the mobile phase reaches the set temperature before entering the chromatographic column 7. The temperature control of the two heating cavities is independent of each other and does not interfere with each other, and can simultaneously meet the temperature requirements of the chromatographic column 7 and the mobile phase, thereby improving the overall performance of the liquid chromatography analysis. For example, the liquid heating device 3 heats the liquid pipeline 10 entering the chromatographic column 7, and through the calculation of the heat conductivity, the entering liquid can reach a safe temperature of 50°C when flowing out of the liquid heating device 3, and the temperature is controllable. The air heating device 2 in the box body 1 ensures that the heating source temperature is within the safe range of not more than 80°C, and can also heat the air temperature in the box body 1 to a maximum of 70°C. PID temperature control is more accurate and has a smaller fluctuation range.

[0038] By using the internal circulation heating of the air heating device 2 and combining the heating of the liquid pipeline 10 by the liquid heating device 3, simultaneous heating of the liquid pipeline and the air inside the box body 1 can be achieved, the heating time is short, the internal air and the column temperature are consistent, there is no heat loss, and the efficiency is greatly improved.

[0039] Further, as shown in Figure 2 The liquid heating device 3 is a column structure, and the outer surface of the column structure is sequentially provided with a plurality of annular grooves in the height direction of the column structure to accommodate the liquid pipeline 10.

[0040] The liquid heating device 3 has a cylindrical shape, which allows it to evenly transfer heat to its surroundings, ensuring uniform heating of the liquid pipeline 10 during the heating process. The shape and size of the groove match the outer diameter of the liquid pipeline 10, allowing it to be tightly accommodated. The design of the annular groove not only provides stable support for the liquid pipeline 10 but also ensures full contact between the pipeline and the heating device during heating, thereby improving heat transfer efficiency.

[0041] The annular grooves are evenly distributed along the height of the column, ensuring that the liquid pipe 10 is uniformly wound around the column, thus avoiding localized overheating or undercooling. By rationally arranging the number and spacing of the annular grooves, it can be ensured that the liquid pipe 10 is heated evenly throughout the heating process, thereby improving the heating effect and the accuracy of temperature control.

[0042] Specifically, the annular grooves are arranged in a spiral pattern. These grooves are not simply arranged parallel to the height of the column, but rather spiral around the surface of the column. Starting from the bottom of the column, each annular groove gradually spirals upwards along the surface until it reaches the top. This spiral arrangement allows the liquid pipe 10 to adhere tightly and evenly to the surface of the column during winding, forming a spiral winding structure. The spiral annular groove design ensures good continuity of the liquid pipe 10 during winding. Compared to traditional parallel groove arrangements, the spiral arrangement can more compactly accommodate the liquid pipe 10, reducing gaps between pipes and thus improving space utilization. Simultaneously, this design maximizes the contact area of ​​the liquid pipe 10 on the surface of the heating device, further improving heat transfer efficiency. Because the pipe winds along a spiral trajectory, heat can be evenly transferred along the length of the pipe, avoiding liquid temperature fluctuations caused by uneven local heating. This uniform heating method is particularly important for heating the mobile phase in liquid chromatography analysis, ensuring that the mobile phase reaches a stable temperature before entering the column 7, thereby improving the accuracy and repeatability of the analysis.

[0043] Furthermore, such as Figure 3 As shown, the air heating device 2 includes: a mounting frame forming an installation space; and two heating element groups 21, which are arranged opposite to each other and spaced apart within the installation space.

[0044] In this embodiment, the mounting frame is used to fix and support the heating fin group 21, ensuring that it remains stable during operation. The mounting frame not only provides physical support for the heating fin group 21, but also serves a protective and isolating function, preventing the heating fin group 21 from being disturbed or damaged during operation. The heating fin group 21 includes eight heating fins. The heating fin group 21 is used to convert electrical energy into heat energy to heat the air. Through the heating of the heating fin group 21, the air is heated in the heating cavity, thereby providing a stable temperature environment for the chromatographic column 7.

[0045] The heating fin group 21 includes a plurality of ceramic semiconductor heating fins, which can not only efficiently convert electrical energy into heat energy, but also achieve uniform heating, rapid response, and high safety. In addition, the long service life, energy-saving characteristics, and easy-to-control features of the ceramic semiconductor heating fins make the heating device more economical, reliable, and efficient during use.

[0046] The air heating device 2 can be provided in two, and the chromatographic column 7 is arranged between the two air heating devices 2.

[0047] As shown in Figure 5 , the air heating device 2 further includes a fan arranged in the mounting space; wherein the upper end of the mounting frame is provided with an air inlet 22, and the lower end of the mounting frame is provided with an air outlet 23.

[0048] Using the principle of hot air rising and cold air descending, the upper slot hole is the air inlet 22, and the lower slot hole is the air outlet 23. The internal circulation heating avoids heat loss, and the box body 1 itself has no air inlet and air outlet, which can avoid dust entering the column oven and harmful gas leaking out.

[0049] Further, as shown in Figure 1 , the liquid chromatographic column 7 oven further includes an adjustable lock buckle 4 having an adjustable clearance space for the chromatographic column 7 of different diameters to pass through, and the back side of the adjustable lock buckle 4 is provided with a threaded hole; a plurality of mounting positions are sequentially arranged on the mounting frame along the height direction of the mounting frame, and the threaded hole is connected with the mounting position through a fastener.

[0050] The adjustable lock buckle 4 has an adjustable clearance space inside, which is usually adjusted by a screw. When the screw is turned, the size of the clearance space inside the lock buckle can be changed, thereby achieving the fixation of chromatographic columns 7 of different diameters. A plurality of mounting positions are sequentially arranged on the mounting frame along the height direction, which can be in the form of threaded holes or clamping grooves. By installing the adjustable lock buckle 4 on the mounting positions at different heights, users can flexibly adjust the installation height of the chromatographic column 7.

[0051] The adjustable lock buckle 4 can adapt to chromatographic columns 7 of different diameters, improving the versatility and compatibility of the equipment. The design of multiple mounting positions allows the chromatographic column 7 to be installed at different height positions as needed, providing users with flexible installation options.

[0052] Further, the liquid chromatography column 7 temperature box further comprises: a temperature detection assembly adapted to detect the heating temperature of the heating cavity; an alarm module arranged on the heating circuit; and an electric control device 8 electrically connected with the temperature detection assembly and the alarm module respectively, so as to control the alarm module to send an alarm signal and cut off the power supply of the heating circuit when the heating temperature reaches the preset temperature.

[0053] In this embodiment, the temperature detection assembly can accurately measure the actual temperature in the heating cavity and convert the temperature signal into an electric signal for transmission to the electric control device 8. By continuously monitoring the temperature change, it is ensured that the temperature in the heating cavity always remains within the set range. When the temperature in the heating cavity reaches or exceeds the preset safety threshold, the alarm module can send an audible and visual alarm signal to remind the operator and automatically cut off the power supply of the heating circuit to prevent equipment damage or safety accidents. The alarm module usually has multiple alarm modes, including sound alarm and light alarm. The sound alarm sends a loud alarm sound through a buzzer, and the light alarm reminds the operator through a flashing indicator light 11.

[0054] The electric control device 8 receives the temperature signal transmitted by the temperature detection assembly and adjusts the power of the heating circuit according to the preset temperature value and control algorithm, such as PID control, to achieve accurate control of the temperature in the heating cavity. When the temperature reaches or exceeds the preset safety threshold, the electric control device 8 can control the alarm module to send an alarm signal and cut off the power supply of the heating circuit.

[0055] The temperature detection assembly measures the temperature in the heating cavity in real time and converts the temperature signal into an electric signal for transmission to the electric control device 8. The electric control device 8 adjusts the power of the heating circuit according to the received temperature signal and the preset temperature value through the PID control algorithm to keep the temperature in the heating cavity within the set range. When the temperature measured by the temperature detection assembly reaches or exceeds the preset safety threshold, the electric control device 8 triggers the alarm module to send an audible and visual alarm signal and cuts off the power supply of the heating circuit to prevent equipment damage or safety accidents.

[0056] Further, as shown in Figure 6 The electric control device 8 includes a safety circuit, which includes: an alternating current power circuit provided with a circuit breaker 13, the allowable current of the circuit breaker 13 being 6 amperes; a power socket 12 arranged on the alternating current power circuit; an indicator light 11 arranged on the alternating current power circuit between the power socket 12 and the circuit breaker 13; and a relay 14 connected to the alternating current power circuit.

[0057] In this embodiment, the AC power circuit is the basis of the entire safety circuit, which introduces the external AC power, usually 220V or 110V, into the device and distributes it to various parts through components such as circuit breaker 13 and relay 14. Power socket 12 is used to connect the external power cord to provide power to the device. Indicator light 11 is used to show whether the AC power circuit between power socket 12 and circuit breaker 13 is powered on. When the power circuit is powered on, indicator light 11 is on; when the power circuit is powered off, indicator light 11 is off. Through the state of indicator light 11, the user can intuitively understand the power status of the device.

[0058] The circuit breaker 13 is provided in the AC power circuit, and the allowable current of the circuit breaker 13 is 6 amperes, which can not only meet the normal operation requirements of the device, but also automatically cut off the power when the current in the circuit exceeds 6 amperes, ensuring that the power is cut off in time in abnormal situations, protecting the safety of the device and the user, and preventing the device from being damaged or causing a fire.

[0059] The user connects the external power cord to the device through the power socket 12. When the power is connected, the circuit breaker 13 starts to work to protect the circuit from overload and short circuit. When the power circuit is powered on, the indicator light 11 is on, indicating that the device is powered normally. If the power circuit is powered off, the indicator light 11 is off, reminding the user that the device is not powered. The temperature detection component of the electric control device 8 monitors the temperature in the heating cavity in real time. When the temperature reaches the preset safety threshold, the electric control device 8 triggers the relay 14 to cut off the power of the heating circuit to prevent the device from being damaged due to overheating. At the same time, the circuit breaker 13 will automatically cut off the power when the current exceeds the allowable value, further protecting the safety of the circuit. Through the state of the indicator light 11, the user can intuitively understand the power status of the device. If the indicator light 11 is off, the user can check whether the power socket 12 is normally powered or whether the circuit breaker 13 is tripped.

[0060] Further, the liquid chromatography column 7 temperature box also includes a liquid leakage sensor, which is arranged at the bottom of the first heating cavity, and the liquid leakage sensor is in communication connection with the electric control device 8 and the alarm module. If the data detected by the liquid leakage sensor exceeds the preset value, the alarm module is triggered to send an alarm signal and / or cut off the power.

[0061] In this embodiment, as shown in Figure 4 The bottom of the first heating cavity is provided with a liquid leakage tray 9, and the liquid leakage sensor 5 is arranged on the liquid leakage tray 9, which can ensure that even a small amount of liquid leakage can be detected in time.

[0062] The liquid leakage sensor monitors the liquid leakage condition of the bottom of the first heating cavity in real time. When liquid leaks to the bottom of the first heating cavity, the liquid leakage sensor detects the presence of the liquid, converts the detected liquid data into an electric signal, and transmits the electric signal to the electric control device 8 through a communication line. After receiving the data transmitted by the sensor, the electric control device 8 compares the data with a preset value. If the detected data exceeds the preset value, the electric control device 8 determines that there is liquid leakage. The electric control device 8 triggers the alarm module to issue an audible and visual alarm signal to remind the operator to pay attention. At the same time, the electric control device 8 can cut off the power supply to prevent safety accidents caused by liquid leakage.

[0063] Therefore, the column oven is additionally provided with the high-precision and high-sensitivity liquid leakage sensor, which can play a good safety warning role on the dripping of some high-risk chemicals. Once the liquid leakage alarm is triggered, the audible and visual alarm will alarm, and the alarm signal can be connected to an external industrial computer to remotely monitor the equipment alarm information. At the same time, the equipment is automatically powered off for 10 seconds to avoid hidden dangers caused by continuous heating.

[0064] The utility model further provides a liquid chromatograph, include: the liquid chromatographic column 7 temperature box of any one, the chromatographic column 7, be located in the liquid chromatographic column 7 temperature box.

[0065] Obviously, the above embodiments are only examples for clearly illustrating, and not limit the embodiments.

[0066] For those skilled in the art, other different forms of changes or variations can be made on the basis of the above description. Here, it is not necessary and impossible to enumerate all the embodiments. The obvious changes or variations derived therefrom are still within the protection scope of the utility model.

Claims

1. A liquid chromatography column oven, characterized by, include: The housing is equipped with a first heating chamber and a second heating chamber; An air heating device is disposed in the first heating chamber and is adapted to heat the heating chamber; A liquid heating device is disposed in the second heating chamber. The outer surface of the liquid heating device is wrapped with a liquid pipeline, and the liquid heating device is adapted to heat the liquid pipeline.

2. The liquid chromatography column oven of claim 1, wherein, The liquid heating device is a cylindrical structure, and the outer surface of the cylindrical structure has a plurality of annular grooves arranged sequentially in the height direction of the cylindrical structure to accommodate the liquid pipeline.

3. The liquid chromatography column oven of claim 2, wherein, The annular grooves are arranged in a spiral shape.

4. The liquid chromatography column oven of any one of claims 1 to 3, wherein, The air heating device includes: The mounting bracket creates an installation space. Two heating element groups are arranged opposite each other and spaced apart within the installation space.

5. The liquid chromatography column oven of claim 4, wherein, The air heating device also includes: A fan is provided in the installation space; The mounting bracket has an air inlet at its upper end and an air outlet at its lower end.

6. The liquid chromatography column oven of claim 4, wherein, Also includes: The adjustable latch has adjustable clearance to allow chromatographic columns of different diameters to pass through, and the back of the adjustable latch has a threaded hole. Multiple mounting positions are sequentially arranged on the mounting frame along the height direction of the mounting frame, and the threaded holes are connected to the mounting positions by fasteners.

7. The liquid chromatography column oven of any one of claims 1 to 3, wherein, Also includes: A temperature detection component, adapted to detect the heating temperature of the heating chamber; The alarm module is located on the heating circuit. An electronic control device is electrically connected to the temperature detection component and the alarm module respectively, so as to control the alarm module to issue an alarm signal and cut off the power supply to the heating circuit when the heating temperature reaches the preset temperature.

8. The liquid chromatography column oven of claim 7, wherein, The electronic control device includes a safety circuit, which includes: The AC power supply circuit is equipped with a circuit breaker, the allowable current of which is 6 amps; A power socket is provided on the AC power circuit; An indicator light is provided on the AC power circuit between the power socket and the circuit breaker; A relay is connected to the AC power supply circuit.

9. The liquid chromatography column oven of claim 7, wherein, Also includes: A leakage sensor is located at the bottom of the first heating chamber. The leakage sensor is communicatively connected to the electronic control device and the alarm module. If the data detected by the leakage sensor exceeds a preset value, the alarm module is triggered to issue an alarm signal and / or cut off the power supply.

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