Sample blending device and automatic sample injection and dilution system

Abstract

The utility model discloses a sample mixing device and an automatic sample feeding and diluting system, insertion holes for placing sampling test tubes are uniformly distributed on the circumference of a turntable of the sample mixing device, and the turntable is driven by a stepping motor I to intermittently rotate so as to sequentially convey the sampling test tubes to sampling positions; a uniform mixing mechanism for driving the corresponding sampling test tube to rotate is arranged at the sampling position and comprises an upper magnetic body and a lower magnetic body; the lower magnetic body comprises a lower base body installed on the stepping motor II, and an N-pole permanent magnet and an S-pole permanent magnet are arranged in the lower base body. The upper magnetic body comprises an upper base body mounted at the lower end of the rotating shaft, an S-pole permanent magnet and an N-pole permanent magnet are arranged in the upper base body, a shaft body of the rotating shaft is mounted in a bearing, the bearing is mounted in each insertion hole, and the upper end of the rotating shaft is connected with a test tube seat sleeve arranged in each insertion hole; a magnetic coupling distance of 0.3 mm to 1.2 mm is kept between the upper base body and the lower base body; the automatic sample injection and dilution system comprises a sample mixing device, a sampling mechanism and a cleaning mechanism.

Description

Technical Field

[0001] This utility model relates to detection technology, specifically a sample mixing device and an automatic sample injection and dilution system, which are suitable for high-precision liquid processing scenarios such as analytical chemistry and medical testing. Background Technology

[0002] In existing technologies, sample dilution and mixing mostly rely on manual labor or independent equipment, which suffers from problems such as low efficiency, susceptibility to contamination, and cumbersome procedures. Specifically:

[0003] 1. Dilution problem: Traditional pipette operation requires frequent tip changes and incomplete cleaning, leading to cross-contamination.

[0004] 2. Mixing defects: Existing mixing techniques such as oscillation, vortex or tumbling require additional equipment, have poor adaptability and complex structure.

[0005] 3. Insufficient automation: Existing devices mostly require step-by-step operation and lack an integrated process of mixing, injection, and dilution. Utility Model Content

[0006] To address the shortcomings of existing technologies, this invention proposes a sample mixing device and an automatic sample injection and dilution system to overcome the problems of high mixing difficulty, low efficiency of sample dilution methods, and difficulty in complete cleaning during sampling, which can lead to sample contamination.

[0007] This utility model's sample mixing device includes a turntable with evenly distributed holes on its circumference for placing sample tubes. The turntable rotates intermittently under the drive of a stepper motor I and a synchronous belt pulley transmission pair, sequentially delivering each sample tube to the sampling position. The difference lies in:

[0008] 1. A mixing mechanism is provided at the sampling position to drive the corresponding sampling tube to rotate autonomously. The mixing mechanism includes an upper magnetic body and a lower magnetic body.

[0009] 2. The lower magnetic body includes a lower base mounted on the output shaft of the stepper motor II, and the lower base is provided with left and right N-pole permanent magnets and S-pole permanent magnets.

[0010] 3. The upper magnetic body includes an upper base installed at the lower end of the rotating shaft. The upper base is provided with left and right S-pole permanent magnets and N-pole permanent magnets. The shaft of the rotating shaft is installed in the bearing. The bearing is installed at the bottom of each insertion hole. The upper end of the rotating shaft is connected to the test tube seat sleeve built into each insertion hole.

[0011] 4. A magnetic coupling distance of 0.3 mm to 1.2 mm is maintained between the upper substrate and the lower substrate.

[0012] Furthermore, a forward and backward motion mechanism is provided to drive stepper motor II into and out of the sampling position.

[0013] Furthermore, one structure of the forward and backward motion mechanism includes a slide block slidably mounted on the left and right linear guide pairs I, a stepper motor II mounted on the slide block, and the slide block moving forward and backward on the left and right linear guide pairs I under the drive of the ball screw transmission pair I driven by the stepper motor III.

[0014] This utility model relates to an automatic sample injection and dilution system, which includes a sample mixing device, a sampling mechanism, and a cleaning mechanism.

[0015] 1. The cleaning mechanism includes a cleaning sleeve, on which a cleaning inlet pipe and a cleaning outlet pipe are connected.

[0016] 2. The sampling mechanism includes a sampling arm, which moves up and down along the left and right linear guide pairs II under the drive of the ball screw transmission pair II driven by the stepper motor IV. The overhanging end of the sampling arm is provided with a sampling needle that penetrates the cleaning sleeve downward and is aligned with the sampling test tube at the sampling position. The sampling needle is a double-lumen needle tube. At the top of the sampling needle, one lumen is connected to the sampling tube and the other lumen is connected to the sampling test tube.

[0017] 3. At the limited position of the sampling arm's descent, the sampling needle is inserted into the sampling tube and the lower tip of the sampling needle does not touch the bottom of the sampling tube. At the limited position of the sampling arm's ascent, the sampling needle is withdrawn from the sampling tube and the tip of the sampling needle is inside the cleaning sleeve.

[0018] The beneficial effects of this utility model are:

[0019] 1. The sample mixing device of this utility model achieves autonomous rotation and mixing of the sampling tube through non-contact magnetic coupling drive, filling the gap in the prior art; the use of non-contact mixing avoids the contamination introduced by traditional stirring rods, making it particularly suitable for aseptic testing scenarios; the energy efficiency of magnetic coupling drive is improved, with the efficiency of magnetic coupling transmission reaching up to 92%, saving more than 40% energy compared to traditional vibration mixing; the magnetic coupling drive can be intelligently controlled, supporting gradient mixing modes (such as low-speed wetting followed by high-speed mixing), and adopts a compatible design, with the mixing module adaptable to various specifications of test tubes from 5mL to 50mL.

[0020] 2. The automatic sample injection and dilution system of this utility model can be used in conjunction with the detection instrument to perform sample injection and dilution, such as automatic sampling of test tubes, automatic liquid addition and dilution, automatic detection, and cleaning of sampling needles and liquid circuits after completion. Especially when the number of samples is large, it can effectively reduce manual steps and improve the detection efficiency of the instrument.

[0021] 3. In the automatic sample dilution system of this utility model, the sampling mechanism, the cleaning mechanism, the turntable mechanism and the mixing mechanism work together to achieve cyclic, precise and automatic sampling, dilution and cleaning operations.

[0022] 4. The automatic sample dilution system of this utility model eliminates the need for disposable sampling nozzles, effectively saving costs and being energy-efficient and environmentally friendly. Attached Figure Description

[0023] Figure 1 This is a first-view isometric view of one embodiment of the present invention.

[0024] Figure 2 for Figure 1 Second-view isometric view of the implementation method.

[0025] Figure 3 for Figure 1 First-view isometric view of the sampling and cleaning mechanism assembly in the implementation method.

[0026] Figure 4 for Figure 3 Second-person isometric view.

[0027] Figure 5 for Figure 1 Isometric view of the turntable in the implementation method.

[0028] Figure 6 for Figure 1 Axonometric view of the mixing mechanism in the implementation method.

[0029] Figure Number Identifiers: 1. Turntable; 2. Sampling Test Tube; 1-1. Insertion Hole; 3. Stepper Motor I; 4. Synchronous Belt Pulley Drive Pair; 5. Stepper Motor II; 6. Lower Base; 7. N-Pole Permanent Magnet; 8. S-Pole Permanent Magnet; 9. Rotating Shaft; 10. Upper Base; 11. Bearing; 12. Test Tube Sleeve; 13. Forward and Backward Motion Mechanism; 13-1. Linear Guide Pair I; 13-2. Slide; 13-3. Ball Screw Drive Pair I; 14. Stepper Motor III; 15. Sampling Arm; 16. Stepper Motor IV; 17. Ball Screw Drive Pair II; 18. Linear guide pair II; 19. Cleaning sleeve; 20. Cleaning inlet pipe; 21. Cleaning outlet pipe; 22. Sampling needle; 23. Sampling tube; 24. Sampling test tube; 25. Motor base I; 26. Base; 27. Sampling frame; 28. Photoelectric sensor baffle I; 29. ​​Upper photoelectric sensor; 30. Lower photoelectric sensor; 31. Cleaning frame; 32. Zero position photoelectric sensor; 33. Photoelectric sensor baffle II; 34. Support; 35. Photoelectric sensor baffle III; 36. Mixing position photoelectric sensor; 37. Retaining ring. Detailed Implementation

[0030] The technical solution of this utility model will be further described below with reference to the embodiments shown in the accompanying drawings.

[0031] The present invention provides an automatic sample dilution system, comprising a sampling mechanism, a cleaning mechanism, a turntable 1, and a mixing mechanism based on a base 26.

[0032] The sampling mechanism is located on the rear right side of the base 26, including a sampling frame 27 fixed to the base 26. The sampling frame 27 includes a top plate, a bottom plate, and a side plate connected to the rear side of the top plate and the bottom plate. A stepper motor IV 16 is mounted on the top plate. A sampling arm 15 is provided between the top plate and the bottom plate. A ball screw drive pair II 17 is provided between the stepper motor IV 16 and the top plate and the bottom plate. The stepper motor IV 16 drives the sampling arm 15 to rise and fall between the top plate and the bottom plate along the left and right linear guide pairs II 18 through the ball screw drive pair II 17. Each linear guide pair II 18 includes a slidingly fitted guide rod and a ball linear bearing. The left and right guide rods are vertically arranged between the top plate and the bottom plate on both sides of the screw of the ball screw drive pair II 17. The left and right ball linear bearings are located inside the sampling arm 15 on both sides of the nut of the ball screw drive pair II 17. Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown.

[0033] The left end of the sampling arm 15 is a cantilever. A sampling needle 22 is vertically installed downwards in the hole at the left end of the cantilever. The sampling needle 22 is a double-lumen needle tube. The downward position of the sampling needle 22 is the sampling position. At the top of the sampling needle 22, one lumen is connected to a sampling tube 23 located above the sampling arm 15, and the other lumen is connected to a sampling test tube 24 located above the sampling arm 15. A forward-extending photoelectric sensor baffle I 28 is installed on the cantilever. Corresponding to the photoelectric sensor baffle I 28, an upper photoelectric sensor 29 and a lower photoelectric sensor 30 are provided on the side plate of the sampling frame 27. When the sampling arm 15 rises and falls, the photoelectric sensor baffle I 28 senses the upper photoelectric sensor 29 and the lower photoelectric sensor 30 respectively, thus limiting the height position of the sampling arm 15 when it rises and falls. Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown.

[0034] The cleaning mechanism includes a cleaning sleeve 19. The upper and lower interfaces on the side of the cleaning sleeve 19 are respectively connected to a cleaning inlet pipe 20 and a cleaning outlet pipe 21. The sampling needle 22 passes through the cleaning sleeve 19. The cleaning sleeve 19 is mounted on the side plate of the sampling frame 27 via a cleaning frame 31. The installation height of the cleaning sleeve 19 corresponds to the upper photoelectric sensor 29; that is, when the sampling arm 15 stops at the limited upward position, the lower tip of the sampling needle 22 is inside the cleaning sleeve 19. Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown.

[0035] The turntable 1 is located on the left side of the sampling mechanism. The I-shaped turntable 1 is mounted above the base 26 via a drive shaft. A stepper motor I3 is mounted on the rear side of the turntable 1 via a motor mount I25 on the base 26. The stepper motor I3 is connected to the drive shaft via a synchronous belt pulley drive pair 4. The synchronous belt pulley drive pair 4 includes a driving pulley and a driven pulley connected by a synchronous belt. The driving pulley is mounted on the downward-facing output shaft of the stepper motor I3, and the driven pulley is mounted on the drive shaft between the turntable 1 and the base 26. The circumference of the turntable 1 is evenly distributed with upper and lower alignment holes 1-1. Each of the upper and lower insertion holes 1-1 can vertically place a sampling test tube 2. A stepper motor I3 drives the turntable 1 to rotate intermittently via a synchronous belt pulley transmission pair 4, transferring each sampling test tube 2 to the sampling position. Corresponding to the sampling position, a zero-position photoelectric sensor 32 is also installed on the base 26. A photoelectric sensor baffle II 33 is provided on the lower part of the turntable 1 corresponding to the zero-position photoelectric sensor 32. Each time the turntable 1 rotates one revolution, the photoelectric sensor baffle II 33 triggers the zero-position photoelectric sensor 32 once, thereby calibrating the origin position of the turntable 1 for each rotation, thus ensuring that each sampling test tube 2 reaches the sampling position accurately. Figure 1 , Figure 2 , Figure 5 As shown.

[0036] The mixing mechanism includes a forward and backward motion mechanism 13 located behind the sampling mechanism. The forward and backward motion mechanism 13 includes a slide block 13-2 slidably mounted on left and right linear guide pairs I 13-1. The left and right linear guide pairs I 13-1 are mounted on front and rear supports 34, which are mounted on a base 26. A stepper motor III 14 is mounted on the rear support 34. The slide block 13-2, driven by the ball screw transmission pair I 13-3 driven by the stepper motor III 14, moves forward and backward on the left and right sides respectively. The linear guide I13-1 on the right moves forward and backward; a stepper motor II5 is installed on the left extension of the slide 13-2, and a photoelectric sensor baffle III35 is installed on the right side of the slide 13-2. The slide 13-2 drives the stepper motor II5 forward to the bottom of the turntable 1 at the sampling position. At this time, the output shaft (extending upward) of the stepper motor II5 is coaxial with the corresponding socket 1-1, and the photoelectric sensor baffle III35 is aligned with the mixing position photoelectric sensor 36 installed on the base 26. Figure 1 , Figure 2 , Figure 6 As shown.

[0037] A lower magnetic body is coaxially mounted on the output shaft of the stepper motor II 5. The lower magnetic body includes a lower base 6, with tile-shaped grooves on the left and right sides extending inward from the bottom of the lower base 6. Left and right N-pole permanent magnets 7 and S-pole permanent magnets 8 are embedded inside the left and right tile-shaped grooves, respectively. Each permanent magnet is made of neodymium iron boron. Figure 6 As shown.

[0038] There are multiple upper magnetic bodies that can be magnetically coupled with the lower magnetic body, and their number is equal to the number of insertion holes 1-1 of the turntable 1. Each upper magnetic body includes an upper base 10 coaxially mounted on the lower end of the rotating shaft 9. A tile-shaped groove is formed from the top of the upper base inwards at left and right positions. Left and right S-pole permanent magnets 8 and N-pole permanent magnets 7 are embedded inside the left and right tile-shaped grooves. The material of each permanent magnet is neodymium iron boron. The shaft of the rotating shaft 9 is mounted in a bearing 11. The bearing 11 is mounted at the bottom of the corresponding lower insertion hole 1-1 and is axially limited downwards by a retaining ring 37. A test tube holder 12 (serving as a support for the sampling test tube 2) is also provided in the lower insertion hole 1-1. The test tube holder 12 is threadedly connected to the upper end of the rotating shaft 9. A magnetic coupling distance of 0.3mm to 1.2mm is maintained between the bottom of the upper base 10 at the bottom of the turntable 1 and the top of the lower base 6. Figure 5 , Figure 6 As shown.

[0039] The operation mode of the automatic sample dilution system of this utility model is as follows:

[0040] 1. First, calibrate the starting position of turntable 1, then place N sampling tubes 2 containing samples into the corresponding sockets 1-1 on turntable 1, with the bottom of each sampling tube 2 resting in the corresponding tube holder 12.

[0041] 2. Stepper motor I3 starts, and turntable 1 rotates to transfer the first sampling tube 2 to the sampling position.

[0042] 3. Stepper motor Ⅲ14 starts rotating forward. Slide 13-2 moves stepper motor Ⅱ5 forward. When photoelectric sensor baffle Ⅲ35 triggers the mixing position photoelectric sensor 36, stepper motor Ⅲ14 stops. Slide 13-2 delivers stepper motor Ⅱ5 to the sampling position. At this time, the lower magnetic body on the output shaft of stepper motor Ⅱ5 is coaxially aligned with the upper magnetic body below the sampling position.

[0043] 4. Stepper motor II5 starts and drives the lower magnetic body to rotate. Under the influence of magnetic pole coupling effect, the upper magnetic body also rotates, which in turn drives the sampling tube 2 to rotate and mix the sample.

[0044] 5. Stepper motor Ⅳ16 starts in the forward direction, sampling arm 15 drives sampling needle 22 to descend (extend cleaning sleeve 19) and enter sampling tube 2 at sampling position until photoelectric sensor baffle Ⅰ28 and lower photoelectric sensor 30 are sensed and stop. At this time, the tip of sampling needle 22 does not touch the bottom of sampling tube 2.

[0045] 6. Sampling and dilution are carried out through sampling tube 23, and sampling and testing are carried out through sampling test tube 24.

[0046] 7. After dilution and sampling are completed, stepper motor IV16 starts in reverse, and sampling arm 15 drives sampling needle 22 to rise and move out of sampling tube 2 until photoelectric sensor baffle I28 and photoelectric sensor 29 are sensed and stop. At this time, the tip of sampling needle 22 returns to the inside of cleaning sleeve 19.

[0047] 8. Cleaning fluid is injected into the cleaning sleeve 19 through the cleaning inlet tube 20 to clean the tip surface and needle hole of the sampling needle 22. The cleaning fluid is then quickly extracted from the cleaning sleeve 19 through the cleaning outlet tube 21 to complete the cleaning process.

[0048] 9. Stepper motor I3 starts, turntable 1 rotates and transfers the second sampling tube 2 to the sampling position, while the first sampling tube 2, which has been diluted, is rotated out of the sampling position.

[0049] 10. Repeat steps 3 to 9 to automatically complete the automatic sample dilution operation in the second sampling tube 2.

[0050] 11. By continuously repeating steps 2 to 9, the automatic sample dilution operation of all samples in sampling tube 2 will be completed automatically.

[0051] 12. After the operation is completed, stepper motor Ⅲ14 reverses and starts, and slide block 13-2 moves stepper motor Ⅱ5 backward out of the sampling position.

Claims

1. A sample mixing device, comprising a turntable (1), wherein the turntable (1) is provided with evenly distributed insertion holes (1-1) for placing sampling test tubes (2) on its circumference, the turntable (1) being driven intermittently by a synchronous belt pulley transmission pair (4) driven by a stepper motor I (3) to sequentially deliver each sampling test tube (2) to the sampling position, characterized in that: A mixing mechanism is provided at the sampling position to drive the corresponding sampling test tube (2) to rotate autonomously. The mixing mechanism includes an upper magnetic body and a lower magnetic body. The lower magnetic body includes a lower base (6) mounted on the output shaft of the stepper motor II (5), and the lower base (6) is provided with left and right N-pole permanent magnets (7) and S-pole permanent magnets (8); The upper magnetic body includes an upper base (10) installed at the lower end of the rotating shaft (9). The upper base (10) is provided with left and right S-pole permanent magnets (8) and N-pole permanent magnets (7). The shaft of the rotating shaft (9) is installed in a bearing (11). The bearing (11) is installed at the bottom of each insertion hole (1-1). The upper end of the rotating shaft (9) is connected to the test tube seat (12) built into each insertion hole (1-1). The upper substrate (10) and the lower substrate (6) maintain a magnetic coupling distance of 0.3 mm to 1.2 mm.

2. The sample mixing device according to claim 1, characterized in that: It is equipped with a forward and backward motion mechanism (13) that drives stepper motor II (5) to enter and exit the sampling position.

3. The sample mixing device according to claim 2, characterized in that: The forward and backward motion mechanism (13) includes a slide (13-2) slidably mounted on the left and right linear guide pairs I (13-1). The stepper motor II (5) is mounted on the slide (13-2). The slide (13-2) moves forward and backward on the left and right linear guide pairs I (13-1) under the drive of the ball screw transmission pair I (13-3) driven by the stepper motor III (14).

4. An automated sample dilution system, characterized in that... The sample mixing device as described in claim 3 further includes a sampling mechanism and a cleaning mechanism: The cleaning mechanism includes a cleaning sleeve (19), on which a cleaning inlet pipe (20) and a cleaning outlet pipe (21) are connected; The sampling mechanism includes a sampling arm (15). The sampling arm (15) moves up and down along the left and right linear guide pairs (18) driven by the ball screw transmission pair II (17) driven by the stepper motor IV (16). The overhanging end of the sampling arm (15) is provided with a sampling needle (22) that penetrates the cleaning sleeve (19) downward and is aligned with the sampling test tube (2) at the sampling position. The sampling needle (22) is a double-lumen needle tube. At the top of the sampling needle (22), one lumen is connected to the sampling tube (23) and the other lumen is connected to the sampling test tube (24). At the limited position where the sampling arm (15) is lowered, the sampling needle (22) is inserted into the sampling tube (2) and the lower tip of the sampling needle (22) does not touch the bottom of the sampling tube (2). At the limited position where the sampling arm (15) is raised, the sampling needle (22) is withdrawn from the sampling tube (2) and the tip of the sampling needle (22) is inside the cleaning sleeve (19).

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