Magnetic frame for nucleic acid extraction

Abstract

The utility model discloses a magnetic rack for nucleic acid extraction, which comprises a reagent tube support, the upper end of the reagent tube support is provided with a plurality of rows of limiting holes, reagent tubes are movably mounted on the plurality of rows of limiting holes, a plurality of magnetic beads are placed in the reagent tubes, the reagent tube support is provided with a strip hole, and the strip hole is provided with a plurality of magnetic beads. The magnetic support is movably mounted on the inner wall of the elongated hole, the magnetic support is improved, after the magnetic support is matched with an external high-speed rotating mixing instrument matched with the connecting bolt and an extracting solution in the reagent tube is shaken up, the magnetic support is inserted from the inserting hole in the cover plate and the elongated hole in the test tube support, and the magnetic support is inserted into the test tube support through the inserting hole in the cover plate and the elongated hole in the test tube support. At the moment, the reagent tubes in the limiting holes in the test tube bracket can be magnetically attracted by the magnets on the magnetic frame, so that the reagent tubes are inclined at a certain angle, and the problem that the reagent tubes are taken down from shaking equipment and placed on the magnetic frame in sequence after being shaken up in sequence in the prior art can be effectively avoided; therefore, the working efficiency can be obviously improved.

Description

Technical Field

[0001] This utility model relates to the field of magnetic rack technology, specifically a magnetic rack for nucleic acid extraction. Background Technology

[0002] A magnetic nucleic acid extraction rack is an experimental tool specifically designed for nucleic acid purification using the magnetic bead method. It is typically made of corrosion-resistant materials (such as plastic or stainless steel) and contains a built-in permanent magnet or electromagnetic structure. Its core function is to generate a high-intensity magnetic field, causing magnetic microspheres adsorbed with nucleic acids to rapidly aggregate to the sidewall of the test tube, achieving efficient separation of the liquid and solid phases.

[0003] In the existing technology, the materials need to be mixed evenly during the nucleic acid extraction process. The current method is to use a rotary mixer to mix the materials in the reagent tube evenly, and then place it on a magnetic rack to hold the magnetic beads. This method requires multiple transfers of the reagent tube, which is not only cumbersome but also time-consuming.

[0004] Therefore, a magnetic rack for nucleic acid extraction is proposed. Utility Model Content

[0005] The purpose of this invention is to provide a magnetic rack for nucleic acid extraction to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a magnetic frame for nucleic acid extraction, comprising a reagent tube support, wherein the upper end of the reagent tube support has multiple rows of limiting holes, and a reagent tube is movably installed on each of the multiple rows of limiting holes. Several magnetic beads are placed inside the reagent tube. The reagent tube support has an elongated hole, and a magnetic support is movably installed on the inner wall of the elongated hole. The magnetic support is provided with multiple magnets, and the multiple magnets are magnetically attracted to the several magnetic beads.

[0007] Preferably, a cover plate is movably installed on the reagent tube holder, and a hand-tightening screw is threaded on both ends of the cover plate. Threaded holes are opened on both ends of the reagent tube holder, and the bottom ends of the two hand-tightening screws are respectively screwed into the inner walls of the two threaded holes.

[0008] Preferably, the cover plate has a plug hole, the position of which coincides with the elongated hole, and the magnetic support passes through the plug hole.

[0009] Preferably, a connecting pin is installed on the bottom side of the reagent tube holder, and the connecting pin is a hollow square structure.

[0010] Preferably, a support plate is installed on the reagent tube holder, the support plate is in contact with the reagent tube, and the support plate can be inclined.

[0011] Compared with the prior art, the beneficial effects of this utility model are:

[0012] This invention improves the magnetic frame by using an external high-speed rotary mixer that is compatible with the connecting pin. After the extract in the reagent tube is shaken, the magnetic frame is inserted through the insertion hole on the cover plate and the elongated hole on the test tube holder. At this time, the magnet on the magnetic frame can magnetically attract the reagent tube in the upper limit hole of the test tube holder, thereby tilting the reagent tube at a certain angle. This effectively avoids the traditional method of shaking the reagent tubes one by one and then removing them from the shaking device and placing them on the magnetic frame, thus significantly improving work efficiency. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the main structure of this utility model;

[0014] Figure 2 This is a bottom view of the structure of this utility model;

[0015] Figure 3 This is a schematic diagram of the separation structure of the reagent tube holder, cover plate, and magnetic holder of this utility model;

[0016] Figure 4 This is a schematic diagram of the separation structure of the reagent tube holder and the cover plate of this utility model;

[0017] Figure 5 This is a cross-sectional view of the reagent tube holder, cover plate, and magnetic holder of this utility model.

[0018] Figure 6 This is a schematic diagram of the magnetic connection between the magnet and the magnetic bead of this utility model.

[0019] Figure 7 This is a schematic diagram illustrating the usage process of the magnetic support of this utility model;

[0020] In the diagram: 1. Reagent tube holder; 2. Limiting hole; 3. Reagent tube; 4. Magnetic bead; 5. Elongated hole; 6. Cover plate; 7. Threaded hole; 8. Hand screw; 9. Magnetic support; 10. Magnet; 11. Connecting pin; 12. Support plate; 13. Insertion hole. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Example: Please refer to Figure 1-7This utility model provides a technical solution: a magnetic frame for nucleic acid extraction, including a reagent tube support 1. The upper end of the reagent tube support 1 has multiple rows of limiting holes 2, and reagent tubes 3 are movably mounted on each of the multiple rows of limiting holes 2. Several magnetic beads 4 are placed inside the reagent tubes 3. The reagent tube support 1 has elongated holes 5, and a magnetic support 9 is movably mounted on the inner wall of the elongated holes 5. The magnetic support 9 has multiple magnets 10, which magnetically attract the magnetic beads 4. A support plate 12 is mounted on the reagent tube support 1, and the support plate 12 is in contact with the reagent tubes 3. The device can be tilted. After the reagent tube holder 1 is shaken and removed from the high-speed rotary mixer, the magnetic holder 9 is inserted into the insertion hole 13 on the cover plate 6 and the elongated hole 5 on the reagent tube holder 1. The magnet 10 on the magnetic holder 9 can then magnetically attract the magnetic beads 4 in the reagent tube 3. The support plate 12 on the reagent tube holder 1 allows the magnetic beads 4 in the reagent tube 3 to be magnetically attracted to the magnet 10 on the magnetic holder 9. When the reagent tube 3 is tilted at a certain angle, it will be closer to the magnet 10, thereby improving the adsorption efficiency and adsorption effect.

[0023] Furthermore, a cover plate 6 is movably installed on the reagent tube holder 1. Both ends of the cover plate 6 are threaded with hand-tightening screws 8. Both ends of the reagent tube holder 1 have threaded holes 7. The bottom ends of the two hand-tightening screws 8 are screwed onto the inner walls of the two threaded holes 7. The cover plate 6 has an insertion hole 13, which coincides with the position of the elongated hole 5. The magnetic support 9 passes through the insertion hole 13. The cover plate 6 is fixed to the reagent tube holder 1 using the hand-tightening screws 8. This effectively secures the upper end of the reagent tube 3, preventing spillage during shaking. Simultaneously, the insertion hole 13 on the cover plate 6 and the elongated hole 5 on the reagent tube holder 1 facilitate the convenient insertion of the magnetic support 9 into the reagent tube holder 1 for use.

[0024] Furthermore, a connecting pin 11 is installed on the bottom side of the reagent tube holder 1, and the connecting pin 11 is a hollow square structure. The setting of the connecting pin 11 makes it easy to use with a high-speed rotary mixer after the reagent tube 3 is installed on the reagent tube holder 1, so as to make it easy to shake the extract in multiple reagent tubes 3 on the reagent tube holder 1 as a whole.

[0025] The working principle is as follows: After the reagent tubes 3 containing the extract are placed into the limiting holes 2 on the reagent tube holder 1, the cover plate 6 is placed on the upper end of the reagent tube holder 1 to block the reagent tubes 3. At the same time, the hand screw 8 on the cover plate 6 is aligned with the threaded hole 7 on the reagent tube holder 1, so that the hand screw 8 on the cover plate 6 can be screwed into the threaded hole 7 on the reagent tube holder 1, thereby firmly fixing the cover plate 6 on the reagent tube holder 1 to lock the upper end of the reagent tubes 3. Then, the connecting pin 11 on the reagent tube holder 1 is inserted into the high-speed rotary mixer, and the reagent tubes 3 on the reagent tube holder 1 are shaken at high speed using the high-speed rotary mixer. After shaking, the reagent tube holder 1 is removed from the high-speed rotary mixer. Then, the magnetic support 9 is inserted into the insertion hole 13 on the cover plate 6 and the elongated hole 5 on the reagent tube holder 1, so that the magnet 10 on the magnetic support 9 can magnetically attract the magnetic beads 4 in the reagent tubes 3.

[0026] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A magnetic stand for nucleic acid extraction, characterized by: The reagent tube holder (1) has multiple rows of limiting holes (2) at its upper end. A reagent tube (3) is movably installed on each of the multiple rows of limiting holes (2). Several magnetic beads (4) are placed inside the reagent tube (3). The reagent tube holder (1) has an elongated hole (5). A magnetic support (9) is movably installed on the inner wall of the elongated hole (5). The magnetic support (9) has multiple magnets (10). The multiple magnets (10) and the multiple magnetic beads (4) are magnetically attracted to each other.

2. The magnetic stand for nucleic acid extraction according to claim 1, wherein: A cover plate (6) is movably installed on the reagent tube holder (1). A hand screw (8) is threaded on both ends of the cover plate (6). A threaded hole (7) is opened on both ends of the reagent tube holder (1). The bottom ends of the two hand screws (8) are respectively screwed into the inner walls of the two threaded holes (7).

3. The magnetic stand for nucleic acid extraction according to claim 2, wherein: The cover plate (6) has a plug hole (13) which coincides with the position of the elongated hole (5), and the magnetic support (9) passes through the plug hole (13).

4. The magnetic stand for nucleic acid extraction according to claim 1, wherein: A connecting pin (11) is installed on the bottom side of the reagent tube holder (1), and the connecting pin (11) is a hollow square structure.

5. The magnetic stand for nucleic acid extraction according to claim 1, wherein: A support plate (12) is installed on the reagent tube holder (1), the support plate (12) is in contact with the reagent tube (3), and the support plate (12) can be inclined.

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