16-hole extraction and purification magnetic frame

Abstract

The utility model relates to the technical field of extraction and purification, in particular to a 16-hole extraction and purification magnetic frame which comprises an upper shell, a transparent support is mounted at the top end of the upper shell, and 16 centrifugal tube mounting holes are formed in the surface of the transparent support; the bottom end of the upper shell is connected with a lower cover plate, eight magnet containing cavities are formed in the upper shell, and a set of magnet assembly is installed in each magnet containing cavity. According to the utility model, an experiment operator can directly observe whether the magnetic beads become clear or not through the transparent bracket without taking up the magnetic frame, so that the operation becomes simple; the elastic frame with elastic deformation is used for fixing the centrifugal tubes, so that the magnetic frame can be compatible with the centrifugal tubes produced by different manufacturers in the market; meanwhile, a plastic material is adopted for integral injection molding, so that the production efficiency is greatly improved, and the material cost is reduced; by adopting the magnet assembly, the adsorption time of the magnetic beads can be shortened, the service time is shortened, and the production efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of extraction and purification technology, specifically a 16-well magnetic extraction and purification rack. Background Technology

[0002] Currently, commonly used magnetic racks for extraction and purification have the following problems: First, there is a large gap when the magnetic rack is used with centrifuge tubes from different brands, which can easily cause the centrifuge tubes to shake, making experimental operation inconvenient. The centrifuge tubes and the magnetic rack do not fit tightly, reducing the compatibility of consumables. Second, the support material of the magnetic rack is not transparent, making it difficult to observe the state of the magnetic beads inside the centrifuge tubes, increasing the difficulty of the experiment. In addition, the magnets are exposed on the outer surface, which can easily lead to rusting and reduce their service life. Utility Model Content

[0003] The purpose of this invention is to provide a 16-well magnetic extraction and purification rack to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a 16-well extraction and purification magnetic rack, comprising an upper shell, a transparent support installed at the top of the upper shell, and 16 centrifuge tube mounting holes with equal diameter at the top of each centrifuge tube mounting hole; a lower cover plate connected to the bottom of the upper shell, which is fixedly connected to the upper shell by four hexagonal screws; eight magnet cavities are provided inside the upper shell, and a set of magnet assemblies is installed inside each magnet cavity, the eight sets of magnet assemblies are arranged with alternating N and S poles, and each magnet assembly is composed of a rectangular magnet and a trapezoidal magnet.

[0005] Preferably, four elastic frames are integrally injection molded on the surface of the transparent bracket and below each centrifuge tube mounting hole. These elastic frames have elastic deformation capability, enabling compatibility with centrifuge tubes of different sizes, and can also fix the centrifuge tubes in place.

[0006] Preferably, the bottom surface of the upper housing has four sets of screw holes, and the surface of the lower cover plate has four sets of thread-through holes. When the lower cover plate is installed with the upper housing, one end of the hexagonal screw passes through the thread-through hole and is threaded and fastened to the screw hole.

[0007] Preferably, the surface of the upper housing is provided with a housing positioning through groove, and the surface of the lower cover plate is provided with a cover plate positioning through groove, and after the lower cover plate is installed with the upper housing, the cover plate positioning through groove and the housing positioning through groove are mutually connected.

[0008] Preferably, a positioning cylinder is integrally injection molded at the center of the bottom of the transparent bracket, and when the transparent bracket is installed with the upper shell, the positioning cylinder extends into the interior of the positioning through groove of the shell and the positioning through groove of the cover plate. The positioning cylinder is used for positioning during the installation of the upper shell.

[0009] Preferably, the transparent bracket has limiting slots at both ends, and when the transparent bracket is installed with the upper housing, the two limiting slots pass through both ends of the upper housing. The limiting slots are used for limiting the upper housing after installation.

[0010] Compared with the prior art, the beneficial effects of this utility model are:

[0011] This extraction and purification magnetic rack uses a split transparent support, allowing operators to directly observe whether the magnetic beads have become clear without picking up the rack, simplifying the operation. Furthermore, each centrifuge tube mounting hole in the transparent support uses an elastically deformable spring frame to fix the centrifuge tube, making this magnetic rack compatible with centrifuge tubes from different manufacturers on the market.

[0012] The main body of this extraction and purification magnetic rack is made of plastic material through one-piece injection molding, which greatly improves production efficiency and reduces material costs compared to aluminum alloy material processing.

[0013] The magnetic rack for extraction and purification uses a combination of rectangular and trapezoidal magnets, which can maintain a good surface fit with the conical centrifuge tube, shortening the magnetic bead adsorption time, reducing usage time, and improving production efficiency. Attached Figure Description

[0014] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0015] Figure 2 This is a schematic diagram of the exploded structure of this utility model in its upright position;

[0016] Figure 3 This is a schematic diagram of the exploded structure of this utility model in an oblique position;

[0017] Figure 4 This is a schematic diagram of the oblique partial explosion structure of this utility model.

[0018] In the diagram: 1. Upper shell; 11. Shell positioning slot; 12. Screw hole; 13. Magnet cavity; 2. Transparent bracket; 21. Limiting slot; 22. Positioning cylinder; 3. Centrifuge tube mounting hole; 31. Elastic frame; 4. Lower cover plate; 40. Hexagonal screw; 41. Through hole; 42. Cover plate positioning slot; 5. Magnet assembly; 51. Rectangular magnet; 52. Trapezoidal magnet. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, not all embodiments. In addition, the terms "first", "second", "third", "upper", "lower", "left", "right", etc. are used for descriptive purposes only and should not be construed as indicating or implying relative importance. At the same time, in the description of the present utility model, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present utility model.

[0020] This utility model provides a structure for a 16-well extraction and purification magnetic rack, as follows: Figure 1 as well as Figure 3 As shown, the device includes an upper shell 1 made of plastic material. A transparent bracket 2 made of plastic material is installed on the top of the upper shell 1. The surface of the transparent bracket 2 has 16 centrifuge tube mounting holes 3, and the upper end of each centrifuge tube mounting hole 3 is set with the same diameter. Four elastic frames 31 are integrally injection molded on the surface of the transparent bracket 2 and below each centrifuge tube mounting hole 3. The elastic frames 31 have elastic deformation capability, which can realize the compatibility function of centrifuge tubes of different sizes. At the same time, the elastic frames 31 can fix the centrifuge tubes.

[0021] During implementation, the magnetic beads are mixed with the substances to be separated in a conical centrifuge tube. The mixed conical centrifuge tube is then directly inserted into the centrifuge tube mounting hole 3 of the transparent support 2. Up to 16 centrifuge tube mounting holes 3 can be placed on the transparent support 2 at the same time. The conical centrifuge tube in each centrifuge tube mounting hole 3 is fixed to the transparent support 2 by the elastic frame 31.

[0022] Furthermore, such as Figure 2 as well as Figure 4 As shown, the bottom end of the upper housing 1 is connected to a lower cover plate 4. The lower cover plate 4 is fixedly connected to the upper housing 1 by four hexagonal screws 40. Specifically, the bottom surface of the upper housing 1 has four sets of screw holes 12, and the surface of the lower cover plate 4 has four sets of thread-through holes 41. When the lower cover plate 4 is installed with the upper housing 1, one end of the hexagonal screw 40 passes through the thread-through hole 41 and is threaded and tightened with the screw hole 12. The interior of the upper housing 1 is provided with eight magnet cavities 13, and each magnet cavity 13 is equipped with a set of magnet assemblies 5. The eight sets of magnet assemblies 5 are arranged in an alternating pattern of N pole and S pole. The magnet assembly 5 is composed of a rectangular magnet 51 and a trapezoidal magnet 52.

[0023] During implementation, the lower cover plate 4 is fixed to the upper shell 1 by hexagonal screws 40; the magnetic beads inside the conical centrifuge tube are attracted by the strong magnetic field generated by the strong magnet of the magnetic assembly 5, and the other unadsorbed liquids are transferred, thus realizing the separation of substances. At the same time, the angle between the inclined surface of the trapezoidal magnet 52 and the inclined surface of the conical centrifuge tube is close, so that the conical centrifuge tube can fit tightly against the surface of the upper shell 1.

[0024] Furthermore, such as Figure 2 as well as Figure 3 As shown, the transparent bracket 2 has limiting slots 21 at both ends. When the transparent bracket 2 is installed with the upper housing 1, the two limiting slots 21 pass through both ends of the upper housing 1. The limiting slots 21 are used for limiting the upper housing 1 after installation. The surface of the upper housing 1 has a housing positioning slot 11, and the surface of the lower cover plate 4 has a cover plate positioning slot 42. After the lower cover plate 4 is installed with the upper housing 1, the cover plate positioning slot 42 and the housing positioning slot 11 communicate with each other. The center of the bottom of the transparent bracket 2 is integrally injection molded with a positioning cylinder 22. When the transparent bracket 2 is installed with the upper housing 1, the positioning cylinder 22 extends into the interior of the housing positioning slot 11 and the cover plate positioning slot 42. The positioning cylinder 22 is used for positioning the upper housing 1 during installation.

[0025] During assembly, the positioning cylinder 22 is extended into the housing positioning groove 11 and the cover plate positioning groove 42 for positioning. The two limiting grooves 21 are used to pass through the two ends of the upper housing 1 for limiting, thus completing the installation of the transparent bracket 2 and the upper housing 1.

[0026] The principle of this invention for purifying substances is as follows: various chemical substances are modified on the surface of paramagnetic materials. Different chemical substances can bind to different target molecules. After binding to the target molecules, the magnetic beads are adsorbed to the side close to the magnetic rack under the action of a magnetic field. Other reagents are discarded to separate the target molecules we want, thereby achieving the purpose of extracting substances from the solution or purifying substances from the solution. This purification method is a common and well-known technology.

[0027] Working principle: The magnetic beads and the substances to be separated are mixed in a conical centrifuge tube. The mixed conical centrifuge tube is directly inserted into the centrifuge tube mounting hole 3 of the transparent support 2. Up to 16 centrifuge tube mounting holes 3 can be placed on the transparent support 2 at the same time. After the conical centrifuge tube in each centrifuge tube mounting hole 3 is fixed on the transparent support 2 by the elastic frame 31, it will be attracted by the strong magnetic field generated by the strong magnet of the magnet assembly 5 placed in the magnet cavity 13. The magnetic beads in the conical centrifuge tube are attracted to one side of the centrifuge tube, and the other unadsorbed liquids are transferred, thus realizing the separation of substances.

[0028] The magnet assembly 5 at the corresponding position of each centrifuge tube mounting hole 3 is composed of a rectangular magnet 51 and a trapezoidal magnet 52. The angle between the inclined surface of the trapezoidal magnet 52 and the inclined surface of the conical centrifuge tube is close, so that the conical centrifuge tube can fit tightly against the surface of the upper shell 1.

[0029] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A 16-well magnetic extraction and purification rack, comprising an upper shell (1), characterized in that: The top of the upper shell (1) is equipped with a transparent bracket (2), and the surface of the transparent bracket (2) is provided with 16 centrifuge tube mounting holes (3), and the upper end of each centrifuge tube mounting hole (3) is set with equal diameter; the bottom end of the upper shell (1) is connected to a lower cover plate (4), which is fixedly connected to the upper shell (1) by four hexagonal screws (40); the interior of the upper shell (1) is provided with eight magnet cavities (13), and each magnet cavity (13) is equipped with a set of magnet assemblies (5). The eight sets of magnet assemblies (5) are arranged in an alternating manner of N pole and S pole. The magnet assembly (5) is composed of a rectangular magnet (51) and a trapezoidal magnet (52).

2. The 16-well extraction and purification magnetic rack according to claim 1, characterized in that: The transparent bracket (2) has four elastic frames (31) integrally injection molded on its surface and below each centrifuge tube mounting hole (3), which can fix the centrifuge tube.

3. The 16-well extraction and purification magnetic rack according to claim 1, characterized in that: The bottom surface of the upper housing (1) is provided with four sets of screw holes (12), and the surface of the lower cover plate (4) is provided with four sets of thread holes (41). When the lower cover plate (4) is installed with the upper housing (1), one end of the hexagonal screw (40) passes through the thread hole (41) and is threaded and fastened to the screw hole (12).

4. The 16-well extraction and purification magnetic rack according to claim 1, characterized in that: The upper housing (1) has a housing positioning through groove (11) on its surface, and the lower cover plate (4) has a cover plate positioning through groove (42) on its surface. After the lower cover plate (4) is installed with the upper housing (1), the cover plate positioning through groove (42) and the housing positioning through groove (11) are in communication with each other.

5. A 16-well extraction and purification magnetic rack according to claim 4, characterized in that: The transparent bracket (2) has an integrally injection-molded positioning cylinder (22) at the center of its bottom. When the transparent bracket (2) is installed with the upper shell (1), the positioning cylinder (22) extends into the interior of the shell positioning groove (11) and the cover plate positioning groove (42). The positioning cylinder (22) is used for positioning during the installation of the upper shell (1).

6. The 16-well extraction and purification magnetic rack according to claim 4, characterized in that: The transparent bracket (2) has limit slots (21) at both ends. When the transparent bracket (2) is installed with the upper shell (1), the two limit slots (21) pass through both ends of the upper shell (1). The limit slots (21) are used for limiting the upper shell (1) after installation.

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