Thyroid function detection assembly

Abstract

The utility model discloses a thyroid function detection assembly. The thyroid function detection assembly comprises a whole blood separation piece and at least one piece of detection test paper, the whole blood separation part is used for filtering red blood cells in blood; the detection test paper comprises a sample receiving end and a detection part, the whole blood separation part is connected with the sample receiving end, and the detection part is used for detecting the concentration of one of thyroid stimulating hormone, free triiodothyronine and free thyroxine. According to the thyroid function detection assembly, the thyroid function can be detected, during detection, the whole blood separation piece can rapidly separate red blood cells in blood within a short time, the rest of the separated blood can enter the detection test paper, detection can be completed by observing the detection part, the blood does not need to be centrifuged into serum, and the detection efficiency is improved. Direct detection of the whole blood sample can be realized, the detection cost is lower, the operation is simple and convenient, the detection time is greatly saved, and the detection efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of thyroid function testing technology, and in particular to a thyroid function testing component. Background Technology

[0002] Thyroid hormone testing is of great clinical significance, mainly used to assess the functional status of the thyroid gland.

[0003] Thyroid hormones include thyroid-stimulating hormone (TSH), total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), and free triiodothyronine (FT3). FT3 (free triiodothyronine) and FT4 (free tetraiodothyronine) are mainly synthesized and secreted by the thyroid gland and are the free forms of T3 and T4, respectively. TSH, as a key hormone in the hypothalamic-pituitary-thyroid axis, is the most sensitive and earliest indicator for identifying thyroid function abnormalities. For example, hyperthyroid patients often have elevated FT3 and FT4, but decreased TSH; hypothyroid patients may have decreased FT3 and FT4, but elevated TSH. For certain special populations, such as patients with hypoproteinemia and pregnant women, testing FT3 and FT4 is more accurate. This is because the physiological conditions of these individuals may interfere with TT3 and TT4 measurements, while FT3 and FT4 more accurately reflect the state of thyroid function. Therefore, the combined detection of these three indicators can determine whether the thyroid gland is in a state of hyperthyroidism or hypothyroidism, which is crucial for maintaining the body's health, helps in the early diagnosis and treatment of thyroid diseases, and fills the gaps in the prevention and treatment of chronic diseases.

[0004] Currently, combined testing of thyroid hormones is usually performed via blood draw, and must be conducted by trained professionals at a facility capable of centrifuging, separating (to produce plasma or serum), and freezing blood samples. Due to the need for specialized equipment and technicians, this testing is typically only available in hospitals or specialized testing facilities, and is expensive and complex. Utility Model Content

[0005] The present invention aims to at least solve one of the technical problems existing in the prior art. Therefore, one objective of the present invention is to provide a thyroid function detection component that can detect thyroid function with low cost and simple operation.

[0006] The thyroid function detection component according to an embodiment of the present invention includes: a whole blood separator for filtering red blood cells from the blood; at least one test strip, the test strip including a sample receiving end and a detection part, the whole blood separator being connected to the sample receiving end, and the detection part being used to detect the concentration of one of thyroid-stimulating hormone, free triiodothyronine, and free thyroxine.

[0007] The thyroid function testing component according to this utility model embodiment incorporates a whole blood separator. This separator rapidly separates blood within a short time, maximally inhibiting hemolysis and improving the reproducibility of test results. It eliminates the need for complex and costly processing of blood samples. The sample filtered by the whole blood separator directly reaches the sample receiving end of the test strip and then enters the detection unit, enabling the detection unit to detect thyroid hormones, free triiodothyronine, and free thyroxine. Therefore, this thyroid function testing component allows for the detection of thyroid function without centrifuging blood into serum, eliminating the need for expensive centrifugation equipment and specialized operators. It enables direct testing of whole blood samples, resulting in lower testing costs, simpler and more convenient operation, significantly reduced testing time, and increased testing efficiency.

[0008] In some embodiments, the thyroid function testing assembly further includes an absorption element connected to the whole blood separator, the absorption element being configured to absorb blood.

[0009] In some embodiments, the test strip has three detection portions, each of which is used to detect the concentration of thyroid-stimulating hormone, the concentration of free triiodothyronine, and the concentration of free thyroxine, respectively.

[0010] In some embodiments, the thyroid function testing assembly further includes a housing having a receiving space and a first opening communicating with the receiving space; the whole blood separator is at least partially disposed within the receiving space and arranged near the first opening; the test strip is disposed in the receiving space; and the housing has a light-transmitting portion at least at a position corresponding to the detection portion.

[0011] In some embodiments, the thyroid function testing assembly further includes a puncture needle disposed at the first opening.

[0012] In some embodiments, the thyroid function testing assembly further includes a telescopic assembly comprising a pressing member, an elastic element, and a connecting rod. The housing has a second opening at one end away from the first opening. The pressing member passes through the second opening and is slidable relative to the housing. The connecting rod connects the pressing member and the puncture needle to allow the puncture needle to move with the pressing member. The elastic element is disposed between the pressing member and the housing to provide a restoring force to the pressing member moving away from the direction of the puncture needle.

[0013] In some embodiments, the whole blood separator is disposed around the puncture needle.

[0014] In some embodiments, three test strips are provided, and the three test strips are distributed around the connecting rod.

[0015] In some embodiments, the puncture needle is configured to extend from the first opening and remain in the extended position, and to retract into the receiving space and remain in the retracted position.

[0016] In some embodiments, the test strip includes a sample pad, a conjugate pad, a test membrane, and an absorbent pad arranged sequentially on a base plate. One end of the sample pad covers one end of the conjugate pad, the other end of the conjugate pad covers one end of the test membrane, and the absorbent pad covers the other end of the test membrane. The sample pad forms the sample receiving end, and the conjugate pad and the test membrane form the detection part.

[0017] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0018] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0019] Figure 1 This is a schematic diagram of the thyroid function testing component according to an embodiment of the present invention, wherein the puncture needle is shown in the extended position.

[0020] Figure 2 This is a schematic diagram of the thyroid function detection component according to an embodiment of the present invention, wherein the puncture needle is shown in the retracted position.

[0021] Figure 3 This is a schematic diagram of the external structure of the thyroid function detection component according to an embodiment of the present invention.

[0022] Figure 4 This is a schematic diagram of the structure of the test strip in the thyroid function detection component of this utility model embodiment.

[0023] Figure 5 This is a schematic diagram of the structure of a thyroid function detection component including a cover, according to an embodiment of the present invention.

[0024] Figure 6 This is a schematic diagram of the cover body in an embodiment of the present utility model.

[0025] Figure label:

[0026] Thyroid function testing component 100;

[0027] 10 whole blood separators;

[0028] Test strip 20;

[0029] Sample receiving end 201; Detection section 202; Sample pad 203; Conjugate pad 204;

[0030] Test membrane 205; absorbent pad 206; base plate 207; test line 208; quality control line 209;

[0031] Absorption element 30;

[0032] 40mm shell;

[0033] Accommodation space 401; First opening 402; Light-transmitting part 403; Second opening 404;

[0034] 50 puncture needles;

[0035] Pressing component 601; elastic element 602; connecting rod 603; fixing plate 604;

[0036] Cover 70; Anti-slip structure 701. Detailed Implementation

[0037] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0038] Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains; the terminology used in the specification of this invention is for the purpose of describing particular embodiments only and is not intended to limit the invention; the terms "comprising" and "having," and any variations thereof, in the specification, claims, and accompanying drawings of this invention are intended to cover non-exclusive inclusion. The terms "first," "second," etc., in the specification, claims, or accompanying drawings of this invention are used to distinguish different objects, not to describe a specific order or hierarchy.

[0039] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," "attachment," and "attachment" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0040] In this invention, the term "and / or" is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. Additionally, in this invention, the character " / " generally indicates that the preceding and following related objects have an "or" relationship.

[0041] In the embodiments of this utility model, the same reference numerals denote the same components, and for the sake of brevity, detailed descriptions of the same components are omitted in different embodiments. It should be understood that the thickness, length, width, and other dimensions of various components in the embodiments of this utility model shown in the drawings, as well as the overall thickness, length, width, and other dimensions of the integrated assembly, are merely illustrative and should not constitute any limitation on this utility model.

[0042] In this utility model, "multiple" refers to two or more (including two).

[0043] The following is combined Figures 1 to 6 The thyroid function detection component 100 of this utility model is described below.

[0044] like Figure 1 and Figure 2 As shown, the thyroid function detection component 100 according to an embodiment of the present invention includes a whole blood separator 10 and at least one test strip 20. The whole blood separator 10 is used to filter red blood cells in the blood. The test strip 20 includes a sample receiving end 201 and a detection part 202. The whole blood separator 10 is connected to the sample receiving end 201, and the detection part 202 is used to detect the concentration of one of thyroid hormones, free triiodothyronine, and free thyroxine.

[0045] Specifically, the whole blood separator 10 filters red blood cells from the blood so that they do not reach the test strip 20. Only the remaining blood reaches the sample receiving end 201 of the test strip 20 through capillary action, and then reaches the detection section 202 for the detection of the concentration of one of thyroid hormones, free triiodothyronine, and free thyroxine. Exemplarily, the whole blood separator 10 can be a whole blood separation membrane, which can be a cellulose or glass fiber deep filtration membrane.

[0046] Specifically, the test strip 20 is connected to the whole blood separator 10. Specifically, the test strip 20 and the whole blood separator 10 are both fixed on the housing 40 or other carrier and only contact each other; or the whole blood separator 10 is directly bonded to the test strip 20.

[0047] Specifically, the thyroid function detection component 100 of this embodiment may include only one test strip 20, meaning that one thyroid function detection component 100 can only detect the concentration of one of thyroid hormones, free triiodothyronine, and free thyroxine. Alternatively, the thyroid function detection component 100 of this embodiment may include two test strips 20, meaning that one thyroid function detection component 100 can detect the concentration of two of thyroid hormones, free triiodothyronine, and free thyroxine. Alternatively, the thyroid function detection component 100 of this embodiment may include three test strips 20, meaning that one thyroid function detection component 100 can simultaneously detect the concentration of thyroid hormones, free triiodothyronine, and free thyroxine.

[0048] For example, the detection unit 202 will show different color depths for blood with different concentrations of thyroid hormones, free triiodothyronine, and free thyroxine. The concentration range can be determined by visual colorimetric observation, so as to know the concentration range of thyroid hormones, free triiodothyronine, and free thyroxine.

[0049] According to the thyroid function detection component 100 of this utility model embodiment, by setting a whole blood separator 10, the whole blood separator 10 can quickly separate blood in a short time, maximally inhibit hemolysis, and improve the reproducibility of test results. This eliminates the need for complex and costly processing of blood samples. The sample filtered by the whole blood separator 10 can directly reach the sample receiving end 201 of the test strip 20, and then enter the detection unit 202, enabling the detection unit 202 to detect thyroid hormones, free triiodothyronine, and free thyroxine. Therefore, the thyroid function detection component 100 of this utility model can detect thyroid function without centrifuging blood into serum, eliminating the need for expensive centrifugation equipment and specialized operators. It allows for direct detection of whole blood samples, resulting in lower detection costs, simpler and more convenient operation, significantly saving detection time and increasing detection efficiency.

[0050] In some embodiments, reference may be made to Figures 1 to 3The thyroid function testing component 100 also includes an absorbent element 30, which is connected to the whole blood separator 10 and is configured to absorb blood. The absorbent element 30 can rapidly absorb a large amount of blood, allowing for a continuous introduction of blood into the whole blood separator 10 over a period of time. Exemplarily, the absorbent element 30 can be a medical-grade sponge, foam, cotton, or paper.

[0051] Specifically, the absorbent element 30 is connected to the whole blood separator 10. Specifically, the absorbent element 30 and the whole blood separator 10 are both fixed on the housing 40 or other carrier and only in contact with each other; or the absorbent element 30 and the whole blood separator 10 are bonded together.

[0052] When in use, you can drop some blood onto the absorbent element 30, immerse the absorbent element 30 into a blood sample, or place it on a pricked finger or a specific area to absorb capillary blood (i.e., peripheral blood) for testing.

[0053] For example, the thyroid function testing component 100 also includes a puncture needle 50 and an absorption element 30. The puncture needle 50 is located at a first opening 402, and the absorption element 30 is connected to the whole blood separator 10 and located at the first opening 402. The absorption element 30 is configured to absorb blood. In the extended position, the puncture needle 50 passes through the absorption element 30, and the tip of the puncture needle 50 extends from the first opening 402. In use, the tip of the puncture needle 50 punctures the fingertip or other part of the subject's body, and the flowing blood can be quickly absorbed by the absorption element 30 and then introduced into the whole blood separator 10.

[0054] In some embodiments, reference may be made to Figure 1 and Figure 2 The test strip 20 has three parts, and the three detection sections 202 of the three test strips 20 are used to detect the concentration of thyroid hormone, the concentration of free triiodothyronine and the concentration of free thyroxine, respectively.

[0055] In the above technical solution, a thyroid function detection component 100 is equipped with three test strips 20. In this way, the concentrations of thyroid hormones, free triiodothyronine, and free thyroxine can be detected simultaneously to achieve joint detection of the three indicators and thus determine thyroid function. The detection process is simple, efficient, and highly accurate.

[0056] For example, three test strips 20 can be fixed on the three circumferential walls of the triangular prism, and the whole blood separator 10 can be fixed on one end of the triangular prism.

[0057] In some embodiments, reference may be made to Figures 1 to 3The thyroid function testing component 100 also includes a housing 40, which has a receiving space 401 and a first opening 402, the first opening 402 being connected to the receiving space 401; the whole blood separator 10 is at least partially disposed in the receiving space 401 and arranged close to the first opening 402; the test strip 20 is disposed in the receiving space 401; and the housing 40 has a light-transmitting part 403 at least at the position corresponding to the detection part 202.

[0058] In use, the end of the housing 40 with the opening can be immersed in blood, allowing blood to enter the receiving space 401 through the first opening 402, and the whole blood separator 10 can come into contact with the blood. Exemplarily, the whole blood separator 10 may be partially located outside the receiving space 401, or its end face may be flush with the first opening 402, allowing direct contact between the blood and the whole blood separator 10. Alternatively, the whole blood separator 10 may be located inside the first opening 402, i.e., entirely within the receiving space 401. In this case, an absorbent element 30 may be provided on the side of the whole blood separator 10 closest to the first opening 402, allowing blood to flow through the absorbent element 30 and come into contact with the whole blood separator 10. The absorbent element 30 may be adhered to the first opening 402, i.e., entirely outside the receiving space 401, or it may be partially located within the receiving space 401.

[0059] In the above embodiment, the test strip 20 and the whole blood separator 10 are placed in the receiving space 401 of the housing 40. In this way, the housing 40 can protect and fix the test strip 20 and the whole blood separator 10, reducing the possibility of contamination or damage to the test strip 20 and the whole blood separator 10. At the same time, it also makes the entire thyroid function detection component 100 larger and easier for users to operate.

[0060] For example, the housing 40 may have an opening area corresponding to the light-transmitting portion 403, and a transparent plastic sheet or transparent glass sheet may be provided in the opening area, forming the light-transmitting portion 403. The light-transmitting portion 403 allows light to pass through so that the testing personnel can observe the state of the testing unit 202 and obtain the test result of the test strip 20. In other embodiments, the housing 40 is entirely transparent to facilitate observation of the state of the testing unit 202.

[0061] In some embodiments, such as Figures 1 to 3 The thyroid function testing component 100 also includes a puncture needle 50, which is located at the first opening 402.

[0062] For example, the puncture needle 50 may always be inserted through the first opening 402 such that the needle tip is outside the housing 40, i.e., the puncture needle 50 is directly fixed to the housing 40. Alternatively, the puncture needle 50 may only extend from the first opening 402 so that the needle tip is outside the housing 40 after being pressed, and the puncture needle 50 may retract from the first opening 402 into the receiving space 401 after the pressing is stopped. Alternatively, the puncture needle 50 may be configured to extend from the first opening 402 and remain in the extended position, and to retract into the receiving space 401 and remain in the retracted position.

[0063] In the above technical solution, the puncture needle 50 can be used to puncture the fingertip. By setting the puncture needle 50, it is convenient and quick to collect blood samples. The absorption element 30 or the whole blood separator 10 can absorb the blood sample from the fingertip. The collection process is safe, hygienic and minimally invasive.

[0064] In some embodiments, reference may be made to Figure 1 and Figure 2 The thyroid function testing component 100 also includes a telescopic component, which includes a pressing member 601, an elastic element 602, and a connecting rod 603. A second opening 404 is provided at the end of the housing 40 away from the first opening 402. The pressing member 601 passes through the second opening 404 and is slidable relative to the housing 40. The connecting rod 603 connects the pressing member 601 and the puncture needle 50 so that the puncture needle 50 moves with the pressing member 601, allowing the puncture needle 50 to pass through the first opening 402 after being pressed, with the needle tip outside the housing 40 to puncture a finger or specific area. The elastic element 602 is disposed between the pressing member 601 and the housing 40 to provide a restoring force to the pressing member 601 to move away from the direction of the puncture needle 50. After pressing stops, the puncture needle 50 can retract from the first opening 402 into the receiving space 401, thus preventing the puncture needle 50 from accidentally puncturing other objects. For example, the elastic element 602 can be a spring.

[0065] For example, the telescopic assembly may include a fixing plate 604, which is disposed in the receiving space 401 and fixed to the housing 40. The fixing plate 604 is provided with a clearance hole or clearance area for clearance of the connecting rod 603. The two ends of the elastic element 602 are respectively connected to the fixing plate 604 and the pressing member 601.

[0066] In other embodiments, one end of the elastic element 602 near the first opening 402 directly abuts against the inner peripheral wall of the housing 40, a limiting protrusion is formed on the side wall of the connecting rod 603, the other end of the elastic element 602 abuts against the limiting protrusion, and the pressing member 601 is sleeved on the end of the connecting rod 603 away from the first opening 402.

[0067] In some embodiments, the whole blood separator 10 is disposed around the puncture needle 50.

[0068] In this way, the whole blood separator 10 can quickly absorb all the blood around the bleeding hole created by the puncture needle 50. For example, the whole blood separator 10 may have a clearance hole to avoid the puncture needle 50. Alternatively, the puncture needle 50 and a portion of the connecting rod 603 may be enclosed in the whole blood separator 10. Or only a portion of the puncture needle 50 may be enclosed in the whole blood separator 10; all of these should be within the scope of protection of this application.

[0069] In some embodiments, the whole blood separator 10 may cover the puncture needle 50, or the absorbent element 30 may cover the puncture needle 50, in order to reduce the possibility of accidental contact between the user and the puncture needle 50.

[0070] In some embodiments, three test strips 20 are provided, and the three test strips 20 are distributed around the connecting rod 603.

[0071] Understandably, the three test strips 20 are used to detect the concentrations of thyroid hormones, free triiodothyronine, and free thyroxine, respectively. Correspondingly, the housing 40 is provided with light-transmitting parts 403 at the positions of the detection parts 202 of the three test strips 20, that is, the housing 40 is surrounded by three light-transmitting parts 403. Thus, the levels of thyroid hormones, free triiodothyronine, and free thyroxine in the blood can be simultaneously determined by visual colorimetric observation, thereby assessing thyroid function. The detection process is simple, efficient, and highly accurate, enabling a triple test for thyroid function.

[0072] In some embodiments, the puncture needle 50 is configured to extend from the first opening 402 and remain in the extended position, and to retract into the receiving space 401 and remain in the retracted position.

[0073] Specifically, the thyroid function testing component 100 also includes a telescopic component, which includes an elastic element 602, a connecting rod 603, a cam, and a button.

[0074] One end of the connecting rod 603 is connected to the puncture needle 50, and the end of the elastic element 602 near the first opening 402 directly abuts against the inner peripheral wall of the housing 40. A limiting protrusion is formed on the side wall of the connecting rod 603, and the other end of the elastic element 602 abuts against the limiting protrusion.

[0075] The housing 40 has a second opening 404 at the end away from the first opening 402. The button passes through the second opening 404 and can slide relative to the housing 40. One end face of the button has eight first serrations, and the circumferential sidewall of one end of the button has eight elongated protrusions that extend along the pressing direction of the button.

[0076] The circumferential sidewall of the cam has four first racks, one end of which has an inclined surface. The cam is used to convert the linear motion of the button into rotational motion. The cam is sleeved on the other end of the connecting rod 603.

[0077] The housing 40 has four second racks circumferentially formed at the position of the button, and a sliding groove is formed between adjacent second racks. Two consecutively arranged second serrations are formed at the end of the second rack facing the cam, and a serration groove is formed between the two second serrations.

[0078] In the retracted position, both the first rack and the elongated protrusion are located in the groove, and the inclined surface of the first rack abuts against the first serration. In the extended position, the elongated protrusion remains in the groove, and the first rack is located in the serrated groove.

[0079] During the process of switching the puncture needle 50 from the retracted position to the extended position and maintaining it in the extended position, firstly, pressing the button will push the cam to move, and then the cam will push the puncture needle 50 to extend through the connecting rod 603. At the same time, the first rack and the elongated protrusion will slide along the slide groove until the first rack moves to disengage from the slide groove. After disengagement, under the push of the elastic element 602, the first rack will slide directly to the bottom between the adjacent first serrations. Then, as the button is released, under the push of the elastic element 602, the cam pushes the button to move away from the first opening 402, and the first rack slides into the serrated groove. At the same time, the cam rotates until the first rack reaches the bottom of the serrated groove, so that the puncture needle 50 is maintained in the extended position.

[0080] During the process of switching the puncture needle 50 from the extended position to the retracted position and maintaining it in the retracted position, firstly, pressing the button will push the cam to move, causing the first rack of the cam to leave the serrated groove. At the same time, the inclined surface of the first rack will re-engage with the first serration. After leaving the serrated groove, the inclined surface of the first rack will slide into the bottom between the first serrations. Then, releasing the button, under the restoring force of the elastic element 602, the inclined surface of the first rack will contact the inclined surface of the second serration that is inclined towards the slide groove and slide into the slide groove along the inclined surface of the second serration, thereby causing the puncture needle 50 to retract and remain in the retracted position.

[0081] By pressing the button, the elastic element 602 is compressed, the puncture needle 50 extends and is locked, and a blood sample is collected quickly and easily by piercing the fingertip. The blood sample from the fingertip is then absorbed. The collection process is safe, hygienic and minimally invasive.

[0082] In some embodiments, reference may be made to Figure 4The test strip 20 includes a sample pad 203, a conjugate pad 204, a test membrane 205, and an absorbent pad 206 arranged sequentially on a base plate 207. One end of the sample pad 203 covers one end of the conjugate pad 204, thus increasing the contact area between them. The other end of the conjugate pad 204 covers one end of the test membrane 205, further increasing the contact area between them. The absorbent pad 206 covers the other end of the test membrane 205, also increasing the contact area between them. The sample pad 203 forms a sample receiving end 201, and the conjugate pad 204 and the test membrane 205 form a detection section 202. The absorbent pad 206 allows the sample to flow more effectively from the sample pad 203 to the detection section 202, while also absorbing any residual sample after testing to prevent contamination of the housing 40.

[0083] More specifically, for the test strip 20 used to detect thyroid-stimulating hormone (TSH), the conjugate pad 204 of the test strip 20 has a TSH monoclonal antibody labeled with colloidal gold or time-resolved fluorescent microspheres; the test membrane 205 has a test line 208 and a control line 209, the test line 208 is coated with another TSH monoclonal antibody, and the control line 209 has a polyclonal antibody that can detect TSH monoclonal antibody, free triiodothyronine monoclonal antibody and free thyroxine monoclonal antibody.

[0084] For the test strip 20 used to detect free triiodothyronine, the conjugate pad 204 of the test strip 20 has a free triiodothyronine monoclonal antibody labeled with colloidal gold or time-resolved fluorescent microspheres, and the test membrane 205 has a test line 208 and a control line 209. The test line 208 is coated with another free triiodothyronine monoclonal antibody, and the control line 209 has a polyclonal antibody that can detect thyroid-stimulating hormone monoclonal antibody, free triiodothyronine monoclonal antibody and free thyroxine monoclonal antibody.

[0085] For the test strip 20 used to detect free thyroxine, the conjugate pad 204 of the test strip 20 has a free thyroxine monoclonal antibody labeled with colloidal gold or time-resolved fluorescent microspheres, and the test membrane 205 has a test line 208 and a control line 209. The test line 208 is coated with another free thyroxine monoclonal antibody, and the control line 209 has a polyclonal antibody that can detect thyroid-stimulating hormone monoclonal antibody, free triiodothyronine monoclonal antibody and free thyroxine monoclonal antibody.

[0086] Among them, colloidal gold labeling is used, which is convenient for operators to observe with the naked eye. In other embodiments, time-resolved fluorescent microspheres are used as markers, which can effectively avoid the influence of background fluorescence and stray light such as excitation light in the sample, and have higher detection sensitivity and anti-interference ability.

[0087] More specifically, the test membrane 205 can be a nitrocellulose membrane.

[0088] During testing, the collected blood sample flows through the whole blood separator 10 via capillary action. The filtered blood sample reaches the sample pad 203 on the test strip 20, and then flows through the conjugate pad 204 and the test membrane 205. After reacting with the antibodies on the test line 208 and the control line 209 on the test membrane 205, it is absorbed by the absorbent pad 206. Finally, the test result of the test strip 20 can be observed through the light-transmitting part 403 corresponding to the test membrane 205 of the test strip 20, thereby determining the user's thyroid function.

[0089] In some embodiments, such as Figure 5 and Figure 6 The thyroid function testing component 100 also includes a cover 70, which is fitted onto the end of the housing 40 that has a first opening 402 and seals the first opening 402. The outer peripheral wall of the cover 70 may be provided with an anti-slip structure 701, such as an anti-slip protrusion, so that the cover 70 can be easily removed from the housing 40.

[0090] Understandably, when not in use, the cover 70 can be placed over the first opening 402 for easy carrying, and even if the puncture needle 50 is accidentally extended, the puncture needle 50 will not puncture a person or other object. In addition, in some embodiments, the cover 70 can also be used to protect the absorption element 30 or the whole blood separator 10.

[0091] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0092] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A thyroid function testing component, characterized in that, include: Whole blood separator (10), said whole blood separator (10) is used to filter red blood cells from blood; At least one test strip (20) is provided, the test strip (20) including a sample receiving end (201) and a detection part (202), the whole blood separator (10) is connected to the sample receiving end (201), and the detection part (202) is used to detect the concentration of one of thyroid-stimulating hormone, free triiodothyronine, and free thyroxine.

2. The thyroid function testing component according to claim 1, characterized in that, It also includes an absorbent element (30) connected to the whole blood separator (10), the absorbent element (30) being configured to absorb blood.

3. The thyroid function testing component according to claim 1, characterized in that, The test strip (20) is provided in three parts, and the three detection parts (202) of the three test strips (20) are respectively used to detect the concentration of thyroid-stimulating hormone, the concentration of free triiodothyronine and the concentration of free thyroxine.

4. The thyroid function testing component according to any one of claims 1-3, characterized in that, It also includes a housing (40) having a receiving space (401) and a first opening (402) communicating with the receiving space (401); the whole blood separator (10) is at least partially disposed in the receiving space (401) and arranged close to the first opening (402); the test strip (20) is disposed in the receiving space (401); and the housing (40) has a light-transmitting part (403) at least at the position corresponding to the detection part (202).

5. The thyroid function testing component according to claim 4, characterized in that, It also includes a puncture needle (50) located at the first opening (402).

6. The thyroid function testing component according to claim 5, characterized in that, It also includes a telescopic assembly, which includes a pressing member (601), an elastic element (602), and a connecting rod (603). The housing (40) has a second opening (404) at one end away from the first opening (402). The pressing member (601) passes through the second opening (404) and is slidable relative to the housing (40). The connecting rod (603) is connected between the pressing member (601) and the puncture needle (50) so that the puncture needle (50) moves with the pressing member (601). The elastic element (602) is disposed between the pressing member (601) and the housing (40) to provide a restoring force to the pressing member (601) in a direction away from the puncture needle (50).

7. The thyroid function testing component according to claim 6, characterized in that, The whole blood separator (10) is arranged around the puncture needle (50).

8. The thyroid function testing component according to claim 6, characterized in that, The test strips (20) are provided in three parts, and the three test strips (20) are distributed around the connecting rod (603).

9. The thyroid function testing component according to claim 5, characterized in that, The puncture needle (50) is configured to extend from the first opening (402) and remain in the extended position, and to retract into the receiving space (401) and remain in the retracted position.

10. The thyroid function testing component according to claim 1, characterized in that, The test strip (20) includes a sample pad (203), a conjugate pad (204), a test membrane (205), and an absorbent pad (206) arranged sequentially on a base plate (207). One end of the sample pad (203) covers one end of the conjugate pad (204), the other end of the conjugate pad (204) covers one end of the test membrane (205), and the absorbent pad (206) covers the other end of the test membrane (205). The sample pad (203) forms the sample receiving end (201), and the conjugate pad (204) and the test membrane (205) form the detection part (202).

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