Heating device for bioreactor-chip reaction

Abstract

This application relates to a heating device for reacting biological reagents with a biochip, comprising: a plurality of uniformly spaced reaction holes on one side surface of a turntable, the reaction holes being used to hold biochip cups; a heating element disposed at the bottom of the reaction holes; and a driving mechanism disposed below the turntable and rotatably connected to the turntable. The uniformly spaced reaction holes on the turntable, and the heating element disposed at the bottom of the reaction holes, allow the biological reagents and biochips in each reaction cup to react under the same temperature and rotational conditions, providing a more stable and suitable environment for the reaction between the biological reagents and the biochip, effectively improving the consistency of the reaction results, and increasing the production efficiency and quality of the biochips.

Description

Technical Field

[0001] This application relates to the field of biochip technology, and in particular to a heating device for reacting biological reagents with a chip. Background Technology

[0002] With the continuous development of medical device technology, in the field of biochip production, it is necessary to provide a suitable temperature environment for the reaction between biological reagents and biochips to promote the relevant reaction between the two, thereby accelerating the production process of biochips.

[0003] In related technologies, the temperature requirements for the reaction between biological reagents and biochips are met through overall heating. Generally, the biochip is placed in the reaction reagent, and a heating element is used to heat the entire reaction area to achieve the appropriate reaction temperature.

[0004] However, in the above heating methods, when multiple reaction cups are placed on the same device, due to the unevenness of the heating method, there is a certain temperature difference between the cups, which causes the reaction effect in different reaction cups to deviate and reduces the consistency of the product.

[0005] In summary, existing heating devices suffer from problems such as uneven heating temperature and poor reaction efficiency. Utility Model Content

[0006] Therefore, it is necessary to provide a heating device for the reaction of biological reagents with chips, addressing the problems of uneven heating temperature and poor reaction effect in existing heating devices.

[0007] A heating device for reacting biological reagents with a chip, comprising:

[0008] The turntable has multiple evenly spaced reaction holes on one side surface, which are used to place chip cups.

[0009] A heating element is disposed at the bottom of the reaction hole;

[0010] A drive mechanism is located below the turntable and is rotatably connected to the turntable.

[0011] In one embodiment, a support is also included, the support being disposed below the turntable;

[0012] The drive mechanism includes a drive motor, a bearing, and a flange. The drive motor is fixed below the bracket. The bearing is installed in the bracket through a bearing sleeve. One end of the bearing is connected to the turntable through the flange, and the other end of the bearing is connected to the output end of the drive motor.

[0013] In one embodiment, the drive mechanism includes a primary transmission mechanism, which includes a primary drive wheel, a primary driven wheel, and a primary synchronous belt. The primary drive wheel is connected to the output end of the drive motor, the primary driven wheel is connected to a bearing, and the primary synchronous belt is sleeved on the primary drive wheel and the primary driven wheel.

[0014] In one embodiment, the drive mechanism includes a secondary transmission mechanism, which includes a secondary drive wheel, a secondary driven wheel, a secondary synchronous belt, and a rotating shaft. The secondary drive wheel is connected to the primary driven wheel via the rotating shaft. The secondary driven wheel is disposed on one side of the secondary drive wheel, and the secondary synchronous belt is sleeved on the secondary drive wheel and the secondary driven wheel.

[0015] In one embodiment, the transmission ratio between the primary transmission mechanism and the secondary transmission mechanism is between 0.5 and 1; the rotation angle of the rotating shaft is between 360° and 720°.

[0016] In one embodiment, the device further includes a rotation limiting structure, a photoelectric sensor, and a light-blocking plate, wherein the rotation limiting structure and the light-blocking plate are respectively disposed on the secondary driven wheel; and the photoelectric sensor is disposed on one side of the secondary driven wheel.

[0017] In one embodiment, a motor tensioning device is also included, the motor tensioning device including a tensioning wheel that abuts against the primary synchronous belt.

[0018] In one embodiment, the bracket includes an upper plate, a lower plate, and support columns, with at least four support columns arranged longitudinally at intervals. The upper plate is disposed at the top of the support columns, the lower plate is disposed at the bottom of the support columns, the bearing sleeve is installed on the upper plate, and the drive motor is fixed to the lower plate.

[0019] In one embodiment, the turntable is an annular structure, and the edge of the annular structure away from the driving mechanism has a plurality of spaced reaction holes; a heat insulation ring is provided between the turntable and the bearing.

[0020] In one embodiment, a heat insulation element is also included, which is disposed on the outer periphery of the reaction hole.

[0021] The heating device described above for the reaction of biological reagents and biochips uses multiple reaction holes evenly distributed on a turntable, with the heating element located at the bottom of the reaction holes. This allows the biological reagents and biochips in each reaction cup to react under the same temperature and rotation conditions, providing a more stable and suitable environment for the reaction of biological reagents and biochips, effectively improving the consistency of the reaction results, and increasing the production efficiency and quality of biochips. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the heating device.

[0023] Figure 2 This is a partial cross-sectional schematic diagram of the heating device.

[0024] In the diagram: 10. Turntable; 11. Reaction port; 12. Turntable cover; 13. Heat insulation ring; 14. Insulation component;

[0025] 20. Heating element;

[0026] 30. Drive mechanism; 31. Drive motor; 32. Bearing; 33. Flange; 341. Primary drive wheel; 342. Primary driven wheel; 343. Primary synchronous belt; 351. Secondary drive wheel; 352. Secondary driven wheel; 353. Secondary synchronous belt; 354. Rotating shaft; 36. Rotation limit structure; 37. Photoelectric sensor; 38. Motor tensioning device;

[0027] 40. Bracket; 41. Upper shelf; 42. Lower shelf; 43. Support column. Detailed Implementation

[0028] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application will be described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0029] In the description of this application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, these terms indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0030] Furthermore, where the terms "first" and "second" appear, these terms are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined with "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, where the term "multiple" appears, "multiple" means at least four, such as two, three, etc., unless otherwise explicitly specified.

[0031] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0032] In this application, unless otherwise expressly specified and limited, the use of descriptions such as "above" or "below" the second feature indicates that the first and second features are in direct contact or indirect contact via an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. Similarly, "below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0033] It should be noted that if an element is referred to as being "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. If an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. If so, the terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used in this application are for illustrative purposes only and do not represent the only possible implementation.

[0034] See Figure 1 , Figure 2 , Figure 1 A schematic diagram of the heating device in one embodiment of this application is shown. Figure 2 A partial cross-sectional schematic diagram of a heating device according to an embodiment of this application is shown.

[0035] One embodiment of this application provides a heating device for the reaction of biological reagents with a chip, including a turntable 10, a heating element 20 and a driving mechanism 30, which meets the heating and rotation requirements in the reaction process of biological reagents and biochips.

[0036] In this embodiment, a plurality of evenly spaced reaction holes 11 are provided on one side surface of the turntable 10, and the reaction holes 11 are used to place the chip cup. The heating element 20 is disposed at the bottom of the reaction holes 11. The driving mechanism 30 is disposed below the turntable 10 and is rotatably connected to the turntable 10.

[0037] Turntable 10 has a ring structure and is made of aluminum alloy, which has good thermal conductivity to ensure uniform heat transfer.

[0038] A plurality of reaction holes 11 are evenly spaced on one side surface of the turntable 10. In this embodiment, the number of reaction holes 11 is set to 60, which are distributed in a circular array on the surface of the turntable 10. The center distance between adjacent reaction holes 11, the diameter and depth of each reaction hole 11 are adapted to the chip cup, so as to stably place the chip cup and prevent the chip cup from shaking or shifting during the rotation of the turntable 10.

[0039] Heating elements 20 are disposed at the bottom of each reaction hole 11. The heating wire is made of nickel-chromium alloy or employs thick-film heating technology. The heating wire is wound to fit tightly against the bottom of the reaction hole 11, ensuring full contact between the heating wire and the bottom of the reaction hole 11 and improving heat conduction efficiency. The heating element 20 is connected to an external power supply via wires and is equipped with a temperature controller. The temperature is controlled at 30℃ with an accuracy of ±1℃, and the heating temperature can be adjusted according to actual needs.

[0040] The heating element 20 employs thick-film heating technology, such as a thin-film heating sheet or a graphene heating film. The thick-film heating circuit is directly printed on the ceramic substrate at the bottom of the reaction hole 11. The ceramic substrate is made of alumina ceramic. Alternatively, the graphene heating film can be bonded to the bottom of the reaction hole 11 using thermally conductive adhesive. The heating element 20 is connected to an external power supply via a flexible circuit board. The flexible circuit board can adapt to minor deformations during the rotation of the turntable 10, ensuring the reliability of the circuit connection.

[0041] The drive mechanism 30 uses a stepper motor or a DC motor. The output shaft of the stepper motor is connected to the turntable 10, and the speed and rotation angle of the turntable 10 can be controlled by controlling the pulse signal of the stepper motor. The output shaft of the DC motor is connected to the turntable 10 through a coupling to ensure the smooth rotation of the turntable 10.

[0042] In the specific implementation process, a chip cup containing biological reagents and a biochip is placed into the reaction port 11 of the turntable 10. Then, the operating temperature of the heating element 20 is set to the appropriate temperature required for the reaction between the biological reagents and the biochip. Next, the drive mechanism 30 is activated, causing the turntable 10 to rotate at a set speed. During rotation, the heating element 20 continuously provides heat to the biological reagents and biochip in the reaction port 11, ensuring a constant reaction temperature.

[0043] As shown above, since multiple reaction holes 11 are evenly spaced on the turntable 10 and the heating element 20 is located at the bottom of the reaction holes 11, the biological reagents and biochips in each reaction cup can react under the same temperature and rotation conditions, providing a more stable and suitable environment for the reaction between biological reagents and biochips, effectively improving the consistency of reaction results, and improving the production efficiency and quality of biochips.

[0044] Combination Figure 2 As shown, Figure 2 This is a partial cross-sectional schematic diagram of the heating device provided in one embodiment of this application. In some embodiments, it further includes a bracket 40, which is disposed below the turntable 10. The bracket 40 is a metal frame structure, and its placement below the turntable 10 provides a mounting base for the drive mechanism 30.

[0045] The drive mechanism 30 includes a drive motor 31, a bearing 32, and a flange 33. The drive motor 31 is fixed below the bracket 40. The bearing 32 is installed in the bracket 40 through a bearing 32 sleeve. One end of the bearing 32 is connected to the turntable 10 through the flange 33, and the other end of the bearing 32 is connected to the output end of the drive motor 31.

[0046] Specifically, the drive motor 31 is a DC geared motor, fixed below the bracket 40. The bearing 32 is installed inside the bracket 40 via a bearing 32 sleeve, and the bearing 32 sleeve is fixedly connected to the bracket 40 by bolts. One end of the bearing 32 is connected to the turntable 10 via a flange 33, which is made of aluminum alloy, and the turntable 10 is connected to the bearing 32 by bolts; the other end of the bearing 32 is connected to the output end of the drive motor 31 via a coupling.

[0047] In one embodiment, the drive mechanism 30 includes a primary transmission mechanism, which includes a primary drive wheel 341, a primary driven wheel 342, and a primary synchronous belt 343. The primary drive wheel 341 is connected to the output end of the drive motor 31, the primary driven wheel 342 is connected to the bearing 32, and the primary synchronous belt 343 is sleeved on the primary drive wheel 341 and the primary driven wheel 342.

[0048] Specifically, the primary transmission mechanism includes a primary drive wheel 341, a primary driven wheel 342, and a primary synchronous belt 343. The primary drive wheel 341 is a small-diameter gear, connected to the output end of the drive motor 31 via a key. The primary driven wheel 342 is a large-diameter gear, connected to the bearing 32. The primary synchronous belt 343 is fitted onto the primary drive wheel 341 and the primary driven wheel 342. Through the primary transmission mechanism, the speed of the drive motor 31 can be reduced and transmitted to the turntable 10, achieving stable rotation of the turntable 10.

[0049] In one embodiment, the drive mechanism 30 includes a secondary transmission mechanism, which includes a secondary drive wheel 351, a secondary driven wheel 352, a secondary synchronous belt 353, and a rotating shaft 354. The secondary drive wheel 351 is connected to the primary driven wheel 342 via the rotating shaft 354. The secondary driven wheel 352 is disposed on one side of the secondary drive wheel 351. The secondary synchronous belt 353 is sleeved on the secondary drive wheel 351 and the secondary driven wheel 352.

[0050] Specifically, the secondary drive wheel 351 is connected to the primary driven wheel 342 via a rotating shaft 354, and the rotating shaft 354 and the primary driven wheel 342 are connected via a spline. The secondary driven wheel 352 is located on one side of the secondary drive wheel 351, and the secondary synchronous belt 353 is sleeved on the secondary drive wheel 351 and the secondary driven wheel 352. The transmission ratio between the primary and secondary transmission mechanisms is 0.5-1. Through the two-stage transmission, the rotational speed and torque of the turntable 10 are controlled. The rotation angle of the rotating shaft 354 is between 360° and 720°, and can be adjusted according to actual needs to meet the requirements of rotation angle in different biological reagents and biochip reactions.

[0051] In the specific implementation process, the drive motor 31 drives the primary drive wheel 341 to rotate. The primary drive wheel 341 drives the primary driven wheel 342 to rotate via the primary synchronous belt 343. The primary driven wheel 342 drives the secondary drive wheel 351 to rotate via the rotating shaft 354. The secondary drive wheel 351 then drives the secondary driven wheel 352 to rotate via the secondary synchronous belt 353, ultimately realizing the rotation of the turntable 10. During the rotation process, the biological reagents and biochips can react fully under uniform temperature and rotation, improving reaction efficiency and product quality.

[0052] Combination Figure 2 As shown, Figure 2 This is a partial cross-sectional schematic diagram of a heating device provided in one embodiment of this application. In some embodiments, it further includes a rotation limiting structure 36, a photoelectric sensor 37, and a light-blocking plate, wherein the rotation limiting structure 36 and the light-blocking plate are respectively disposed on the secondary driven wheel 352; and the photoelectric sensor 37 is disposed on one side of the secondary driven wheel 352.

[0053] Specifically, the rotation limiting structure 36 includes a limiting block disposed on the secondary driven wheel 352, and a bolt head disposed on one side of the secondary driven wheel 352 and mounted on the bracket 40. When the secondary driven wheel 352 rotates to a set angle, the limiting block contacts the bolt head, restricting the rotation of the secondary driven wheel 352, so that the rotation angle of the turntable is controlled between 360° and 720°.

[0054] A light-blocking plate is mounted on the secondary driven wheel 352, and a photoelectric sensor 37 is mounted on one side of the secondary driven wheel 352 via a fixed bracket. The position of the light-blocking plate on the secondary driven wheel corresponds to the zero point position. Each time the system starts, a zeroing operation is performed to ensure consistent position reference. The motion control of the turntable 10 is controlled by a host computer via pulse signals. The number of pulses determines the rotation angle, the pulse frequency determines the rotation speed, and the pulse direction determines the rotation direction. The system drives the secondary driven wheel to reciprocate between the zero position and the set angle according to the pulse signals.

[0055] In one embodiment, a motor tensioning device 38 is also included, which includes a tensioning pulley that abuts against the primary synchronous belt 343.

[0056] Specifically, the motor tensioning device 38 includes a tensioning pulley made of rubber, which is mounted on one side of the primary synchronous belt 343 via an adjustable tensioning bracket. The tensioning pulley abuts against the primary synchronous belt 343. By adjusting the position of the tensioning bracket, the pressure of the tensioning pulley on the primary synchronous belt 343 can be changed, thereby achieving tension adjustment of the primary synchronous belt 343 and ensuring stable operation of the transmission system.

[0057] In one embodiment, the bracket 40 includes an upper plate 41, a lower plate 42, and support columns 43, with at least four support columns 43 arranged longitudinally at intervals. The upper plate 41 is disposed at the top of the support column 43, the lower plate 42 is disposed at the bottom of the support column 43, the bearing 32 is sleeved and installed on the upper plate 41, and the drive motor 31 is fixed to the lower plate 42.

[0058] Specifically, the support frame 40 consists of an upper plate 41, a lower plate 42, and four support columns 43. The four support columns 43 are evenly spaced longitudinally. The upper plate 41 is fixed to the top of the support columns 43 with bolts, and the lower plate 42 is fixed to the bottom of the support columns 43 with bolts. Both the upper plate 41 and the lower plate 42 are rectangular plates.

[0059] Bearing 32 is mounted on the upper plate 41 via a bearing 32 sleeve. Bearing 32 is a tapered roller bearing, and the bearing 32 sleeve is cylindrical with an inner diameter matching the outer diameter of the bearing 32. The bearing 32 sleeve is fixedly connected to the upper plate 41 with bolts to ensure the installation stability of bearing 32.

[0060] The drive motor 31 is fixed to the lower plate 42 by bolts, and its output shaft is connected to the primary transmission mechanism through a coupling.

[0061] In one embodiment, the turntable 10 is an annular structure, and the edge of the annular structure away from the drive mechanism 30 is provided with a plurality of spaced reaction holes 11; a heat insulation ring 13 is provided between the turntable 10 and the bearing 32.

[0062] Specifically, the turntable 10 has an overall ring structure and is made of ceramic composite material, which is resistant to high temperature and chemical corrosion. Sixty reaction holes 11 are evenly distributed along the edge of the ring structure on the side away from the drive mechanism 30. The reaction holes 11 are arranged in a circular array, and the inner walls of the reaction holes 11 are polished to a smooth surface, facilitating the insertion and removal of the chip cup.

[0063] The turntable cover 12 has a ring structure and is located in the middle area of ​​the turntable 10.

[0064] A heat insulation ring 13 is provided between the turntable 10 and the bearing 32. The heat insulation ring 13 is made of aerogel felt or nano heat insulation material, which can effectively prevent the heat on the turntable 10 from being transferred to the bearing 32, reduce heat loss, protect the bearing 32 from high temperature, and extend the service life of the bearing 32.

[0065] In one embodiment, a heat insulation element 14 is also included, which is disposed on the outer periphery of the reaction hole 11.

[0066] Specifically, an insulation element 14 is installed around the reaction hole 11. The insulation element 14 is made of aluminum silicate fiber cotton. The insulation element 14 is annular and is fitted around the reaction hole 11. Its inner diameter is adapted to the outer diameter of the reaction hole 11, which can effectively reduce the heat loss inside the reaction hole 11 and improve the stability and accuracy of temperature control.

[0067] A temperature sensor is installed at the bottom of the reaction port 11, adjacent to the heating film, and can measure the temperature inside the reaction port 11 in real time. The cables of the temperature sensor and the heating film pass through the central hole of the flange 33 of the turntable 10, and connect to the circuit board along the central hole of the rotation shaft 354. The power of the heating film is controlled according to the feedback signal of the temperature sensor to achieve temperature control. At the same time, it avoids the phenomenon of cable tangling caused by the rotation of the turntable 10.

[0068] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0069] The embodiments described above are merely examples of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A heating device for reacting biological reagents with a chip, characterized in that, include: The turntable (10) has a plurality of uniformly spaced reaction holes (11) on one side surface, the reaction holes (11) being used to place chip cups; A heating element (20) is disposed at the bottom of the reaction hole (11); The drive mechanism (30) is located below the turntable (10) and is rotatably connected to the turntable (10).

2. The heating device for reacting biological reagents with a chip according to claim 1, characterized in that, It also includes a bracket (40) disposed below the turntable (10); The drive mechanism (30) includes a drive motor (31), a bearing (32) and a flange (33). The drive motor (31) is fixed below the bracket (40). The bearing (32) is installed in the bracket (40) through a bearing (32) sleeve. One end of the bearing (32) is connected to the turntable (10) through the flange (33), and the other end of the bearing (32) is connected to the output end of the drive motor (31).

3. The heating device for reacting biological reagents with a chip according to claim 2, characterized in that, The drive mechanism (30) includes a primary transmission mechanism, which includes a primary drive wheel (341), a primary driven wheel (342), and a primary synchronous belt (343). The primary drive wheel (341) is connected to the output end of the drive motor (31), the primary driven wheel (342) is connected to the bearing (32), and the primary synchronous belt (343) is sleeved on the primary drive wheel (341) and the primary driven wheel (342).

4. The heating device for reacting biological reagents with a chip according to claim 3, characterized in that, The drive mechanism (30) includes a secondary transmission mechanism, which includes a secondary drive wheel (351), a secondary driven wheel (352), a secondary synchronous belt (353), and a rotating shaft (354). The secondary drive wheel (351) is connected to the primary driven wheel (342) through the rotating shaft (354). The secondary driven wheel (352) is located on one side of the secondary drive wheel (351). The secondary synchronous belt (353) is sleeved on the secondary drive wheel (351) and the secondary driven wheel (352).

5. The heating device for reacting biological reagents with a chip according to claim 4, characterized in that, The transmission ratio between the primary and secondary transmission mechanisms is between 0.5 and 1; the rotation angle of the rotating shaft (354) is between 360° and 720°.

6. The heating device for reacting biological reagents with a chip according to claim 5, characterized in that, It also includes a rotation limiting structure (36), a photoelectric sensor (37) and a light blocking plate, wherein the rotation limiting structure (36) and the light blocking plate are respectively disposed on the secondary driven wheel (352); and the photoelectric sensor (37) is disposed on one side of the secondary driven wheel (352).

7. The heating device for reacting biological reagents with a chip according to claim 3, characterized in that, It also includes a motor tensioning device (38), which includes a tensioning pulley that abuts against the primary synchronous belt (343).

8. The heating device for reacting biological reagents with a chip according to claim 3, characterized in that, The bracket (40) includes an upper plate (41), a lower plate (42), and support columns (43). At least four support columns (43) are arranged longitudinally at intervals. The upper plate (41) is located at the top of the support column (43), and the lower plate (42) is located at the bottom of the support column (43). The bearing (32) sleeve is installed on the upper plate (41), and the drive motor (31) is fixed to the lower plate (42).

9. The heating device for reacting biological reagents with a chip according to claim 3, characterized in that, The turntable (10) has a ring structure, and the edge of the ring structure away from the driving mechanism (30) is provided with a plurality of spaced reaction holes (11); a heat insulation ring (13) is provided between the turntable (10) and the bearing (32).

10. The heating device for reacting biological reagents with a chip according to claim 9, characterized in that, It also includes a heat insulation component (14), which is disposed on the outer periphery of the reaction hole (11).

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