Self-rotating constant-eccentricity spinning equipment for preparing dura mater patch

Abstract

The utility model discloses self-rotating constant-eccentricity spinning equipment for preparing a dura mater patch, which comprises a supporting seat, a rotating device is rotatably arranged on the supporting seat, a cavity is formed in the rotating device, a horn-shaped fixer and a horn-shaped sealing rotator which are connected with each other are arranged in the cavity, and the horn-shaped fixer and the horn-shaped sealing rotator are connected with each other. The rotating device drives the trumpet-shaped fixer, the trumpet-shaped sealing rotator, the rotary infusion tube and the eccentric needle head to rotate and is matched with external propelling equipment such as an electric push rod to push an injection needle cylinder to be precisely propelled, so that fibers are sprayed and scattered on a roller collector of sterile gauze in a spiral branch form; and the fibers are easy to intertwine due to spiral scattering, so that an important role is played in improving the mechanical property of the dura mater patch. And meanwhile, a single fiber generates a small branch structure in the eccentric spinning jet process, so that different fibers can be mutually hooked and connected, and the mechanical property of the fiber membrane is further enhanced.

Description

Technical Field

[0001] This utility model relates to the field of biomedical material production technology, specifically a self-rotating constant eccentric spinning device for preparing dura mater patches. Background Technology

[0002] The dura mater, a crucial barrier between the skull and brain tissue, is frequently damaged during trauma, tumor resection, and neurosurgery. Dura mater repair is essential for preventing cerebrospinal fluid leakage, intracranial infection, and epilepsy. An ideal patch must possess mechanical strength, leak-proof properties, bone-repairing capabilities, biocompatibility, and biodegradability. Currently, clinically used patch materials mainly fall into three categories: autologous periosteum: excellent biocompatibility but requires a second surgery for harvesting, limiting its applicability; allogeneic periosteum: readily available but carries risks of immune rejection and disease transmission; and synthetic polymers: primarily biodegradable materials (such as polylactic acid and hydroxyapatite), low cost and easily scalable, but with drawbacks such as insufficient bioactivity and weak bone regeneration promotion.

[0003] Current synthetic patch fabrication technologies face multiple bottlenecks: traditional cast / blown films have smooth and regular surfaces, offering good leak-proof properties but hindering cell adhesion and bone tissue regeneration; electrospun nanofibers can mimic the extracellular matrix structure to promote repair, but they can also lead to the adhesion and proliferation of brain tissue cells, resulting in brain dysfunction and increasing the risk of epilepsy. To address this issue, multilayer composite structures have been proposed, but the interlayer bonding methods present contradictions: physical stacking leads to low interlayer peel strength and deteriorated mechanical properties; thermal bonding damages the fiber microstructure and weakens the repair-promoting function. Furthermore, existing dura mater patches are generally fixed by sutures or adhesive bonding. Suture fixation is difficult, damages brain tissue, and is prone to cerebrospinal fluid leakage at the suture site; adhesive bonding introduces exogenous components, which may trigger immune rejection and infection.

[0004] In this context, researchers addressed the problem using a multi-layered structure and thermal bonding to integrate the layers into a single unit. However, the independence between the fiber layers dictates that either a loose composite or a unified structure must be formed by altering the fiber microstructure. The former results in poor mechanical strength of the developed dura mater patch, while the latter, due to the disruption of the microstructure of the fibrous cellular matrix, leads to poor repair functionality. Therefore, we propose a self-rotating constant eccentric spinning device for dura mater patch preparation. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the existing defects and provide a self-rotating constant eccentric spinning device for preparing dura mater patches. This device can spray and scatter fibers in a spiral branching shape onto a sterile gauze roller collector, directly achieving a multi-layered self-locking composite structure during the spinning process. This improves the mechanical strength of the dura mater patch and eliminates the need for post-processing hot pressing, avoiding damage to the microstructure of the fibrous cell matrix and enhancing its repair function. This effectively solves the problems in the background technology.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a self-rotating constant eccentric spinning device for preparing dura mater patches, comprising a support base, on which a rotating device is rotatably mounted. The rotating device has a cavity inside, within which a horn-shaped fixer and a horn-shaped sealing rotator are arranged and connected. The horn-shaped fixer and the horn-shaped sealing rotator have a connecting surface at their horn-shaped openings. A fixed infusion tube coaxial with the horn-shaped fixer is arranged inside the horn-shaped fixer, and a rotating infusion tube coaxial with the horn-shaped sealing rotator is arranged inside the horn-shaped sealing rotator. One end of the rotating infusion tube is inserted into the inner side of one end of the fixed infusion tube, and the other end of the rotating infusion tube passes through the support base and connects to an eccentric needle. The other end of the fixed infusion tube passes through the support base and connects to an infusion tube. The infusion tube communicates with the outlet of an injection syringe.

[0007] As a preferred embodiment of this utility model, the support base is mounted on an insulating base, and the insulating base is provided with a drive mechanism for driving the rotating device to rotate.

[0008] As a preferred embodiment of this utility model, the drive mechanism includes a servo motor mounted on an insulating base, a drive pulley mounted on the output shaft of the servo motor, a driven pulley mounted on the outer surface of the rotating device, and a synchronous belt provided between the drive pulley and the driven pulley.

[0009] As a preferred embodiment of this utility model, a high-voltage power supply is provided on the outside of the insulating base, and a high-voltage power line is provided on the high-voltage power supply. The end of the high-voltage power line passes through the insulating base and the support seat and is connected to the eccentric needle.

[0010] As a preferred embodiment of this utility model, a rotary bearing is provided at one of the far ends of the horn-shaped fixture and the horn-shaped sealing rotator.

[0011] As a preferred technical solution of this utility model, the eccentric needle head has an angle range of 120-155° with respect to the needle axis.

[0012] Compared with existing technologies, the beneficial effects of this invention are as follows: A rotating device drives the horn-shaped fixator, horn-shaped sealing rotator, rotating infusion tube, and eccentric needle to rotate. Combined with external propulsion devices such as electric push rods, this propels the injection syringe precisely, causing the fibers to be sprayed and scattered in a spiral, branched pattern onto the sterile gauze roller collector. This spiral scattering easily generates inter-fiber entanglement, which plays a crucial role in improving the mechanical properties of the dura mater patch. Simultaneously, individual fibers generate small branched structures during the eccentric spinning process, causing inter-fiber linkage and further enhancing the mechanical properties of the fiber membrane. The combined effect of these two factors results in a nanofiber membrane with excellent mechanical properties. The interweaving of spiral fibers and the combination of branched structures directly achieve a self-locking composite of multi-layered structures during spinning, improving the mechanical strength of the dura mater patch. Furthermore, the absence of post-processing hot pressing avoids damage to the microstructure of the fibrous cell matrix, thus enhancing its repair functionality. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the structure of this utility model;

[0014] Figure 2 This is a schematic diagram of the internal structure of the rotating device of this utility model;

[0015] Figure 3 This is a schematic diagram of the internal structure of the horn-shaped fixture and the horn-shaped sealing rotator of this utility model;

[0016] Figure 4 This is a partial structural schematic diagram of the present invention;

[0017] Figure 5 This is a schematic diagram of the cross-sectional structure of this utility model.

[0018] In the diagram: 1 High-voltage power supply, 2 High-voltage power cord, 3 Insulating base, 4 Eccentric needle, 5 Support base, 6 Rotating device, 7 Synchronous belt, 8 Servo motor, 9 Infusion tubing, 10 Injection syringe, 11 Horn-shaped retainer, 12 Horn-shaped sealing rotator, 13 Rotary bearing, 14 Fixed infusion tubing, 15 Rotary infusion tubing. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0020] Please see Figure 1-5This utility model provides a technical solution: a self-rotating constant eccentric spinning device for preparing dura mater patches, including a support base 5. The support base 5 is provided with two or U-shaped structures. A cylindrical rotating device 6 is rotatably provided on the support base 5. A cavity is opened inside the rotating device 6. A trumpet-shaped fixing device 11 and a trumpet-shaped sealing rotating device 12 are arranged in the cavity and are connected to each other. The trumpet-shaped fixing device 11 and the trumpet-shaped sealing rotating device 12 are sealed together, and a rotating seal is provided between the trumpet-shaped fixing device 11 and the trumpet-shaped sealing rotating device 12.

[0021] The flared ends of the flared retainer 11 and the flared sealing rotator 12 are the connecting surfaces. A fixed infusion tube 14, coaxial with the flared retainer 11, is housed inside the flared retainer 11. A rotating infusion tube 15, coaxial with the flared sealing rotator 12, is housed inside the flared sealing rotator 12. One end of the rotating infusion tube 15 is inserted into the inside of one end of the fixed infusion tube 14. A rotating seal is provided between the rotating infusion tube 15 and the fixed infusion tube 14, allowing the rotating infusion tube 15 to rotate inside the fixed infusion tube 14 while maintaining a seal.

[0022] The cavity formed by the connection of the horn-shaped retainer 11 and the horn-shaped sealing rotator 12 can collect leakage from the infusion tubing, therefore a sealed connection between the horn-shaped retainer 11 and the horn-shaped sealing rotator 12 is required. In addition, a rotary seal is also provided between the fixed infusion tubing 14 and the horn-shaped retainer 11.

[0023] The other end of the rotary infusion tube 15 passes through the support base 5 and is connected to the eccentric needle 4 via an adapter. The other end of the fixed infusion tube 14 passes through the support base 5 and is connected to the infusion tube 9. The infusion tube 9 is connected to the outlet of the injection syringe 10, which contains the corresponding polymer spinning solution.

[0024] The outer shell of the rotating device 6 is fixedly connected to the trumpet-shaped sealing rotator 12, the rotating infusion tube 15 and the eccentric needle 4 to form a whole.

[0025] The solution in the syringe 10 is propelled forward at a set speed (0.1-8 mL / h) by an external propulsion device such as an electric push rod. The solution sequentially enters the fixed infusion tube 14 and the rotary infusion tube 15, and is ejected from the eccentric needle 4. During the ejection process, the rotating device 6 drives the rotary infusion tube 15 and the eccentric needle 4 to rotate (at a speed of 500-2000 rpm) through the trumpet-shaped fixer 11 and the trumpet-shaped sealing rotator 12. This causes the fibers to be ejected and scattered in a spiral branching pattern onto the sterile gauze roller collector. The spiral scattering easily generates mutual entanglement between fibers, which plays an important role in improving the mechanical properties of the dura mater patch. At the same time, individual fibers generate small branching structures during the eccentric spinning and ejection process, which can cause mutual linkage between different fibers, further enhancing the mechanical properties of the fiber membrane. The combined effect of these two factors results in the nanofiber membrane having excellent mechanical properties. The interweaving of spiral fibers and the combination of branched structures directly achieve a self-locking composite of multi-layered structures during the spinning process, which improves the mechanical strength of the dura mater patch. At the same time, no post-processing hot pressing is required, which avoids damaging the microstructure of the fibrous cell matrix and helps to enhance its repair function.

[0026] In a preferred embodiment, the support base 5 is mounted on an insulating base 3, and the insulating base 3 is provided with a drive mechanism for driving the rotating device 6 to rotate. The drive mechanism includes a servo motor 8 mounted on the insulating base 3, a drive pulley mounted on the output shaft of the servo motor 8, a driven pulley mounted on the outer surface of the rotating device 6, and a synchronous belt 7 between the drive pulley and the driven pulley. The servo motor 8 and the synchronous belt 7 can drive the rotating device 6 to rotate, thereby driving the eccentric needle 4 to rotate and spray the spiral branched fiber.

[0027] The servo motors, electric linear actuators, etc. used in this application are all commonly used electronic components in the prior art. Their specific structures, working principles, control methods, and circuit connections are all well-known technologies and will not be described in detail here.

[0028] In a preferred embodiment, a high-voltage power supply 1 is provided on the outside of the insulating base 3, and a high-voltage power supply line 2 is provided on the high-voltage power supply 1. The end of the high-voltage power supply line 2 passes through the insulating base 3 and the support base 5 and is connected to the eccentric needle 4. The connection method can be to provide an electric clamp at the end of the high-voltage power supply line 2, and to provide a conductive ring at the end of the eccentric needle 4 that is connected to the rotary infusion tube 15 (the end away from the eccentricity). The conductive ring is rotatably mounted on the eccentric needle 4, and the high-voltage power supply line 2 conducts direct current into the eccentric needle 4 through the electric clamp and the conductive ring.

[0029] In a preferred embodiment, a rotary bearing 13 is provided on the outer side of the opposite ends of the horn-shaped retainer 11 and the horn-shaped sealing rotator 12. Specifically, hollow shafts are provided on the opposite ends of both the horn-shaped retainer 11 and the horn-shaped sealing rotator 12. The fixed infusion tube 14 and the rotating infusion tube 15 pass through the corresponding hollow shafts. A rotary bearing 13 is provided between the hollow shaft of the horn-shaped sealing rotator 12 and the corresponding through groove on the side surface of the support base 5. A rotary bearing 13 is also provided between the hollow shaft of the horn-shaped retainer 11 and the corresponding through groove on the side surface of the housing of the rotating device 6, so that the rotating device 6 can drive the horn-shaped sealing rotator 12, the rotating infusion tube 15, and the eccentric needle 4 to rotate.

[0030] In a preferred embodiment, the eccentric needle 4 has an angle between its angle and the needle axis direction ranging from 120° to 155°.

[0031] In the preparation of the dura mater patch, a sterile gauze roller is used as a collector to electrospin different polymer spinning solutions through this equipment to obtain a repair layer. Then, using the same roller covered with the repair layer and sterile gauze as a collector, another polymer spinning solution is used to electrospin through the same equipment to form an anti-adhesion layer on the surface of the repair layer, resulting in a composite layer. Next, using the composite layer covered with sterile gauze as a collector, another polymer spinning solution is used to electrospin, covering a membrane material with pre-cut adhesion-resistant wide edges to obtain a nanofiber membrane. Finally, the nanofiber membrane is cut, and then sequentially subjected to ventilation drying, hot-press lamination, cross-linking, desorption, sealing packaging, and irradiation sterilization to obtain the dura mater patch.

[0032] The parts not disclosed in this utility model are all prior art, and their specific structures, materials, and working principles will not be described in detail. Although embodiments of this utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of this utility model, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A self-rotating constant eccentric spinning device for preparing dura mater patches, comprising a support base (5), characterized in that: A rotating device (6) is rotatably mounted on the support base (5). The rotating device (6) has a cavity inside. A horn-shaped fixer (11) and a horn-shaped sealing rotator (12) are connected to each other inside the cavity. The horn-shaped fixer (11) and the horn-shaped sealing rotator (12) are connected at the horn opening. A fixed infusion tube (14) is coaxial with the horn-shaped fixer (11). A rotating infusion tube (15) is coaxial with the horn-shaped sealing rotator (12). One end of the rotating infusion tube (15) is inserted into the inside of one end of the fixed infusion tube (14). The other end of the rotating infusion tube (15) passes through the support base (5) and is connected to the eccentric needle (4). The other end of the fixed infusion tube (14) passes through the support base (5) and is connected to the infusion tube (9). The infusion tube (9) is connected to the outlet of the injection syringe (10).

2. The self-rotating constant eccentric spinning device for preparing dura mater patches according to claim 1, characterized in that: The support base (5) is mounted on the insulating base (3), and the insulating base (3) is provided with a drive mechanism for driving the rotating device (6) to rotate.

3. The self-rotating constant eccentric spinning device for preparing dura mater patches according to claim 2, characterized in that: The drive mechanism includes a servo motor (8) mounted on an insulating base (3), an active pulley mounted on the output shaft of the servo motor (8), a driven pulley mounted on the outer surface of the rotating device (6), and a synchronous belt (7) between the active pulley and the driven pulley.

4. The self-rotating constant eccentric spinning device for preparing dura mater patches according to claim 3, characterized in that: A high-voltage power supply (1) is provided on the outside of the insulating base (3), and a high-voltage power supply line (2) is provided on the high-voltage power supply (1). The end of the high-voltage power supply line (2) passes through the insulating base (3) and the support base (5) and is connected to the eccentric needle (4).

5. The self-rotating constant eccentric spinning device for preparing dura mater patches according to claim 1, characterized in that: A rotary bearing (13) is provided at one of the far ends of the horn-shaped retainer (11) and the horn-shaped sealing rotator (12).

6. A self-rotating constant eccentric spinning apparatus for preparing dura mater patches according to any one of claims 1-5, characterized in that: The eccentric needle (4) has an angle range of 120-155° with respect to the needle axis.

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