A powder raw material synthesis device for a pharmaceutical intermediate

Abstract

The utility model relates to the technical field of pharmaceutical chemical industry equipment, specifically disclose a kind of powder raw material synthesis equipment of pharmaceutical intermediates, including rack, reaction kettle and control system, the reaction kettle top is equipped with kettle cover, bottom is equipped with quick-opening type discharge valve, the kettle cover is provided with driving device, high pressure electrostatic precipitator and at least one feeding port;The reaction kettle inside is provided with the stirring assembly driven by the driving device;The outer wall of the reaction kettle is peripherally provided with several ultrasonic transducers, all the ultrasonic transducers are fixed to the outer wall of reaction kettle by mounting bracket;The powder raw material synthesis equipment of pharmaceutical intermediates is cooperated by each component, can efficiently solve material wall hanging problem, improve mixing uniformity, realize accurate temperature control and whole course dust control, also have the beneficial effects of convenient and intelligent operation, equipment maintenance is convenient, product quality is stable and meets the clean production requirement.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical and chemical equipment technology, and specifically discloses a device for synthesizing powder raw materials for pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are key materials in the synthesis of active pharmaceutical ingredients (APIs), and the efficiency and purity of their synthesis process directly affect the quality of the final drug. The production of powder intermediates typically involves efficient mixing of solid powders, reactions, and post-processing.

[0003] In the prior art, related synthesis equipment has undergone various improvements. For example, Chinese utility model patent CN2680392U discloses a synthesis equipment for powder raw materials of pharmaceutical intermediates. This equipment achieves online weighing and proportioning of raw materials by setting up a weighing box, pressure sensor, and display. It also utilizes crushing rollers and heating plates in the crushing box to crush and dry the raw materials, and finally mixes them in the mixing box using stirring blades and airflow distribution pipes. This equipment integrates weighing, drying, crushing, and mixing functions, thus improving production efficiency to a certain extent.

[0004] However, the device and the existing technology it represents still have some obvious limitations: Traditional mixing mechanisms rely primarily on mechanical stirring and bottom blowing. For micro-powder materials that are prone to adhesion and have poor flowability, it is difficult to completely solve the problems of "wall adhesion" and "scalding" on the inner wall of the reactor, resulting in reduced effective volume, insufficient mixing uniformity, and difficulty in cleaning, which can easily cause batch-to-batch contamination.

[0005] The integration of functions is rigid: multiple functional modules such as weighing, crushing, drying, and mixing are mechanically linked together, resulting in a large and complex equipment structure with insufficient coordination between the various stages. For example, its drying function is only concentrated in the crushing stage, making it difficult to handle the moisture and volatiles generated or that need to be removed during mixing or reaction.

[0006] Dust control is lacking: During the feeding and reaction process, especially when blowing and stirring, dust is easily generated inside the equipment. However, the existing design lacks an effective built-in dust removal mechanism, which may not only lead to material loss and distorted proportions, but also pose certain safety and occupational health hazards. Dust escape may also cause cross-contamination.

[0007] Therefore, there is an urgent need for a new type of pharmaceutical intermediate powder raw material synthesis equipment that can fundamentally solve the problem of internal wall adhesion, achieve efficient and uniform mixing and reaction, and have in-situ self-cleaning and dust control capabilities, thereby meeting the stringent requirements of modern pharmaceutical industry for high-quality, high-efficiency and high-standard clean production. Utility Model Content

[0008] This invention proposes a powder raw material synthesis equipment for pharmaceutical intermediates. By integrating high-voltage electrostatic dust removal, ultrasonic-assisted dispersion, spiral and scraping combined stirring, and jacket temperature control system, it synergistically solves problems such as wall adhesion, agglomeration, uneven mixing, dust emission, and poor control of reaction conditions in powder synthesis, significantly improving product quality, production efficiency, and operational safety.

[0009] This invention is implemented as follows: a pharmaceutical intermediate powder raw material synthesis device includes a frame, a reaction vessel, and a control system. The reaction vessel has a lid on top and a quick-opening discharge valve at the bottom. The lid is equipped with a drive device, a high-voltage electrostatic precipitator, and at least one feeding port. A stirring assembly driven by the drive device is installed inside the reaction vessel. Several ultrasonic transducers are arranged circumferentially on the outer wall of the reaction vessel, and all ultrasonic transducers are fixed to the outer wall of the reaction vessel by mounting brackets. The stirring assembly includes a rotating shaft connected to the output end of the drive device, spiral blades spirally arranged on the rotating shaft, and a wall-scraping mechanism for scraping the inner wall of the reaction vessel. The wall-scraping mechanism includes at least one connecting rod vertically fixedly connected to the rotating shaft and a scraper located at the end of the connecting rod away from the rotating shaft. The profile of the scraper is adapted to the curvature of the inner wall of the reaction vessel, and the lower end of the scraper is fixedly connected to the lower outer wall of the rotating shaft.

[0010] As a preferred embodiment of the pharmaceutical intermediate powder raw material synthesis equipment of this utility model, the driving device includes a motor disposed above the reactor lid and a reducer connected to the output shaft of the motor. The output shaft of the reducer passes through the reactor lid through a mechanical seal and is connected to the rotating shaft.

[0011] As a preferred embodiment of the powder raw material synthesis equipment for pharmaceutical intermediates according to this utility model, the scraper is made of polytetrafluoroethylene, and the gap between the scraper surface and the inner wall of the reaction vessel is 0.5-2mm.

[0012] As a preferred embodiment of the powder raw material synthesis equipment for pharmaceutical intermediates according to this utility model, the feeding port is a vacuum feeding port, and the reactor lid is also provided with an inert gas interface.

[0013] As a preferred embodiment of the powder raw material synthesis equipment for pharmaceutical intermediates according to this utility model, the outer wall of the reactor is provided with a jacket, and the jacket is connected to a heat transfer oil circulation system.

[0014] In a preferred embodiment of the pharmaceutical intermediate powder raw material synthesis equipment of this utility model, the lid of the reactor and the reactor are detachably and sealed by a quick-release clamp.

[0015] As a preferred embodiment of the powder raw material synthesis equipment for pharmaceutical intermediates according to this utility model, the control system is electrically connected to the drive device, ultrasonic transducer, high-voltage electrostatic precipitator and quick-opening discharge valve.

[0016] The beneficial effects of this utility model are: 1. The high-frequency vibration of the ultrasonic transducer effectively prevents powder agglomeration. Combined with the unique stirring and wall-scraping mechanism composed of spiral blades and polytetrafluoroethylene scrapers, it achieves efficient mixing and synchronous self-cleaning of the inner wall of the reactor, fundamentally eliminating material adhesion, significantly improving mixing uniformity and product consistency, and greatly reducing cleaning difficulty and batch-to-batch contamination risk.

[0017] 2. The functions of mixing, dust removal, temperature control, vacuum, and inert atmosphere treatment are organically integrated into a single reactor, with a compact and reasonable structure. The jacketed heat transfer oil circulation system can provide uniform and precise temperature control for the entire reaction process, overcoming the limitations of the original technology that only heats during the pulverization stage, and realizing efficient synthesis in an integrated manner throughout the entire process.

[0018] 3. A high-voltage electrostatic precipitator is integrated into the reactor lid, which can capture and eliminate dust generated during feeding and reaction in real time, effectively preventing material loss and proportioning distortion, eliminating the risk of dust explosion, improving the working environment, and meeting the GMP requirements for pharmaceutical production. Attached Figure Description

[0019] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0020] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0021] Figure 2 This utility model Figure 2 A schematic diagram of the AA-direction cross-section structure.

[0022] Figure 3 This is a schematic diagram of the structure of the stirring assembly of this utility model.

[0023] The markings in the diagram are: 1. Frame; 2. Reactor; 3. Control system; 4. Reactor cover; 5. Quick-opening discharge valve; 6. Drive unit; 7. High-voltage electrostatic precipitator; 8. Feed port; 9. Stirring assembly; 10. Ultrasonic transducer; 11. Mounting bracket; 12. Rotary shaft; 13. Spiral blade; 14. Connecting rod; 15. Scraper; 16. Motor; 17. Reducer; 18. Mechanical seal; 19. Inert gas interface; 20. Jacket; 21. Heat transfer oil circulation system; 22. Quick-release clamp. Detailed Implementation

[0024] The present invention will be further described below with reference to the accompanying drawings and specific embodiments to aid in understanding its content. Unless otherwise specified, the methods used in this invention are conventional methods; the raw materials and apparatus used, unless otherwise specified, are conventional commercially available products.

[0025] Please see Figure 1-3 A pharmaceutical intermediate powder raw material synthesis device includes a frame 1, a reaction vessel 2, and a control system 3. The reaction vessel 2 is provided with a lid 4 on the top and a quick-opening discharge valve 5 at the bottom. The lid 4 is provided with a drive device 6, a high-voltage electrostatic precipitator 7, and at least one feeding port 8. The reaction vessel 2 is provided with a stirring assembly 9 driven by the drive device 6. Several ultrasonic transducers 10 are arranged circumferentially on the outer wall of the reaction vessel 2. All ultrasonic transducers 10 are fixed to the outer wall of the reaction vessel 2 by mounting brackets 11. The stirring assembly 9 includes a rotating shaft 12 connected to the output end of the drive device 6, a spiral blade 13 spirally arranged on the rotating shaft 12, and a wall scraping mechanism for scraping the inner wall of the reaction vessel 2. The wall scraping mechanism includes at least one connecting rod 14 vertically fixedly connected to the rotating shaft 12 and a scraper 15 arranged at the end of the connecting rod 14 away from the rotating shaft 12. The profile of the scraper 15 is adapted to the curvature of the inner wall of the reaction vessel 2, and the lower end of the scraper 15 is fixedly connected to the lower outer wall of the rotating shaft 12.

[0026] In this embodiment: the drive device provides power, driving the spiral blades 13 to rotate at high speed via the rotating shaft 12; the spiral blades 13 generate strong axial and radial material flow, lifting and pushing the powder at the bottom and center of the reactor 2 upwards and outwards, forcing the material to undergo bulk convection and diffusion, achieving preliminary macro-mixing and preventing powder accumulation at the bottom; the wall scraping mechanism, rotating synchronously with the rotating shaft 12, follows closely behind; its scraper 15 rotates in close contact with the inner wall of the reactor 2 with a very small gap, like a "broom," instantly scraping away the powder adhering to the inner wall due to centrifugal force or stickiness, completely eliminating mixing dead zones, ensuring that all materials participate in mixing, and possessing a self-cleaning function to ensure no residue inside the reactor; the ultrasonic transducer 10 installed on the outer wall of the reactor 2 directly transmits high-frequency vibration energy to the material inside the reactor; the high-frequency mechanical wave energy generates strong shearing force, effectively... The soft agglomerates of the powder solve the problem of easy clumping of micro powders, promote the dispersion and uniform distribution of powder particles at the micro level, and thus significantly improve the mixing uniformity. During the feeding and reaction process, the high-voltage electrostatic precipitator 7 works continuously. It uses a high-voltage electric field to ionize the dust particles raised in the reactor, making them charged and then captured by the dust collecting electrode, thereby effectively suppressing dust emission, ensuring accurate product ratio, reducing the risk of explosion, and providing a clean and safe operating environment. The jacket 20 and the heat transfer oil circulation system 21 provide uniform and precise heating or cooling for the entire reaction process, ensuring that the reaction is carried out under optimal temperature conditions. The inert gas interface 19 and the vacuum feed port are used to replace the reaction atmosphere or evacuate, meeting the requirements of the synthesis process that is sensitive to oxygen and moisture. After the reaction is completed, the quick-opening discharge valve opens rapidly to ensure that the mixed powder is discharged smoothly and quickly.

[0027] As a technical optimization of this utility model, the driving device 6 includes a motor 16 located above the lid 4 and a reducer 17 connected to the output shaft of the motor 16. The output shaft of the reducer 17 passes through the lid 4 via a mechanical seal 18 and is connected to the rotating shaft 12.

[0028] In this embodiment: the power transmission is stable and reliable, while the mechanical seal 18 prevents material leakage and the entry of external impurities, improves the sealing performance and operational stability of the equipment, refines the technical details of the core structure, and enhances the targeting of patent protection.

[0029] As a technical optimization of this utility model, the scraper 15 is made of polytetrafluoroethylene, and the gap between the scraper 15 and the inner wall of the reactor 2 is 0.5-2mm.

[0030] In this embodiment: the polytetrafluoroethylene material has the characteristics of corrosion resistance, high temperature resistance and low coefficient of friction, which can adapt to the complex working conditions in the synthesis process of pharmaceutical intermediates and avoid the generation of impurities and contaminants in the material by friction between the scraper 15 and the inner wall; the gap of 0.5-2mm can ensure that the scraper 15 can effectively scrape the material on the inner wall, while avoiding excessive friction between the scraper 15 and the inner wall, thus extending the service life of the scraper 15 and ensuring stable scraping effect.

[0031] As a technical optimization of this utility model, the feeding port 8 is a vacuum feeding port, and the lid 4 is also provided with an inert gas interface 19.

[0032] In this embodiment: the vacuum feed port enables sealed feeding, reducing dust escape and material loss; the inert gas interface 19 creates an inert reaction environment to prevent material oxidation or moisture absorption, further improving product purity and production safety, making up for the shortcomings of existing equipment in feeding methods and reaction environment control, enriching equipment functions, and enhancing the equipment's adaptability to complex synthesis processes.

[0033] As a technical optimization of this utility model, the outer wall of the reactor 2 is provided with a jacket 20, and the jacket 20 is connected to a heat transfer oil circulation system 21.

[0034] In this embodiment, the jacket 20 enables precise control of the reaction temperature, meeting the different temperature requirements of various pharmaceutical intermediate synthesis processes. It solves the problem that existing equipment can only dry during the pulverization stage and cannot control the temperature during the mixing / reaction process, ensuring that the reaction proceeds efficiently at a suitable temperature and improving product quality and reaction efficiency.

[0035] As a technical optimization of this utility model, the lid 4 and the reactor 2 are detachably sealed by a quick-release clamp 22.

[0036] In this embodiment, the installation and removal of the vessel lid 4 facilitates daily maintenance, cleaning, and internal component repair of the equipment, shortens downtime, and improves production efficiency; at the same time, it ensures the sealing of the connection, prevents material leakage, and meets the stringent requirements of the pharmaceutical industry for equipment cleanliness and sealing.

[0037] As a technical optimization of this utility model, the control system 3 is electrically connected to the drive device 6, the ultrasonic transducer 10, the high-voltage electrostatic precipitator 7, and the quick-opening discharge valve 5.

[0038] In this embodiment, the control system 3 realizes coordinated automated control of various functional components of the equipment, reduces manual operation intervention, reduces human error, ensures the stability of synthesis process parameters (such as stirring speed, ultrasonic frequency, dust removal timing, discharge speed, etc.), improves the consistency of product quality, and enhances the convenience and intelligence of equipment operation.

[0039] Working principle and usage process of this utility model: Close the quick-opening discharge valve, start the equipment through the control system 3, and if necessary, fill the reactor 2 with inert gas through the inert gas interface 19 to replace the air, or create a negative pressure environment by drawing a vacuum through the vacuum feed port; feed the powder raw materials through the feeding port 8 or the vacuum feed port; during this process, the high-voltage electrostatic precipitator 7 on the reactor lid 4 is automatically started to adsorb the escaping dust in real time to prevent material loss and environmental pollution; the drive device is started, driving the rotating shaft 12 and the spiral blade 13 to rotate, realizing the main circulation and mixing of the material; simultaneously, the polytetrafluoroethylene scraper 15 of the wall scraping mechanism rotates close to the inner wall of the reactor 2 to scrape off the adhering material and eliminate dead zones; the ultrasonic transducer 10 is started, and the high-frequency vibration it generates is transmitted to the material through the reactor wall, effectively breaking up powder clumps and promoting mixing and reaction mass transfer; the heat transfer oil circulation system 21 in the jacket 20 precisely controls the temperature of the reaction system according to the reaction requirements through the control system 3; after the reaction is completed, open the quick-opening discharge valve 5, and the uniformly mixed powder product is discharged under the action of gravity and the propulsion of the spiral blade 13, completing one working cycle.

[0040] In the description of this utility model, it should be understood that the terms "left", "right", "up", "down", "top", "bottom", "front", "back", "inner", "outer", "back", "middle", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0041] However, the above description is only a specific embodiment of this utility model and should not be construed as limiting the scope of implementation of this utility model. Therefore, any substitution of equivalent components or equivalent changes and modifications made in accordance with the scope of protection of this utility model should still fall within the scope of the claims of this utility model.

Claims

1. A pharmaceutical intermediate powder raw material synthesis device, comprising a frame (1), a reaction vessel (2), and a control system (3), wherein the reaction vessel (2) is provided with a lid (4) on the top and a quick-opening discharge valve (5) on the bottom, characterized in that: The lid (4) is equipped with a drive device (6), a high-voltage electrostatic precipitator (7), and at least one feeding port (8); the reactor (2) is equipped with a stirring assembly (9) driven by the drive device (6); a plurality of ultrasonic transducers (10) are arranged circumferentially on the outer wall of the reactor (2), and all the ultrasonic transducers (10) are fixed to the outer wall of the reactor (2) by mounting brackets (11); the stirring assembly (9) includes a rotating shaft (12) connected to the output end of the drive device (6). The spiral blades (13) are spirally arranged on the rotating shaft (12), and a wall scraping mechanism is used to scrape the inner wall of the reactor (2). The wall scraping mechanism includes at least one connecting rod (14) that is vertically fixedly connected to the rotating shaft (12) and a scraper (15) disposed at one end of the connecting rod (14) away from the rotating shaft (12). The profile of the scraper (15) is adapted to the curvature of the inner wall of the reactor (2), and the lower end of the scraper (15) is fixedly connected to the lower outer wall of the rotating shaft (12).

2. The equipment for synthesizing powder raw materials of pharmaceutical intermediates according to claim 1, characterized in that: The drive device (6) includes a motor (16) located above the lid (4) and a reducer (17) connected to the output shaft of the motor (16). The output shaft of the reducer (17) passes through the lid (4) via a mechanical seal (18) and is connected to the rotating shaft (12).

3. The equipment for synthesizing powder raw materials of pharmaceutical intermediates according to claim 1, characterized in that: The scraper (15) is made of polytetrafluoroethylene, and the gap between the scraper (15) and the inner wall of the reactor (2) is 0.5-2mm.

4. The equipment for synthesizing powder raw materials of pharmaceutical intermediates according to claim 1, characterized in that: The feeding port (8) is a vacuum feeding port, and the lid (4) is also provided with an inert gas interface (19).

5. The equipment for synthesizing powder raw materials of pharmaceutical intermediates according to claim 1, characterized in that: The outer wall of the reactor (2) is provided with a jacket (20), and the jacket (20) is connected to a heat transfer oil circulation system (21).

6. The equipment for synthesizing powder raw materials of pharmaceutical intermediates according to claim 1, characterized in that: The vessel cover (4) and the reactor (2) are detachably and sealed together by a quick-release clamp (22).

7. The equipment for synthesizing powder raw materials of pharmaceutical intermediates according to claim 1, characterized in that: The control system (3) is electrically connected to the drive device (6), the ultrasonic transducer (10), the high-voltage electrostatic precipitator (7), and the quick-opening discharge valve (5).

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