A stirring device for a reaction vessel for biopharmaceutical synthesis
Patent Information
- Application Number
- CN202522128762.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-09
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2035-10-09
AI Technical Summary
[0003]在传统的生物医药合成用反应容器中，通常采用搅拌杆对溶解在溶剂中的药物进行搅拌混合处理，由于搅拌杆的设计和运动方式限制，反应容器内的溶液可能在不同部位形成浓度梯度，部分药物可能未能充分沾湿或溶解，导致混合不均匀，这种不均匀的混合状态还可能导致反应的选择性下降，形成副产物，进而影响产品的纯度和品质
1.本装置在使用过程中，通过转动机构配合搅拌机构对溶解在溶剂中的药物进行初步搅拌混合处理，同时，配合输送机构使得圆筒内的溶液处于交替流动状态，可以加速反应的进行，提高产物的生成速率，进一步加强混合效果，减少副产物的生成，从而提高产品的纯度和质量。
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Figure CN224686878U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of biomedical synthesis technology, and in particular to a stirring device for a reaction vessel used in biomedical synthesis. Background Technology
[0002] Biopharmaceutical synthesis refers to the process of using organisms or their metabolites to manufacture drugs or drug-related compounds through biosynthesis. This method often involves technologies such as biocatalysis, metabolic engineering, and synthetic biology. With the rapid development of the biopharmaceutical field, biopharmaceutical synthesis has become an increasingly important part of drug research and development and production. In this process, the design of the reaction vessel and the performance of the stirring device directly affect the reaction efficiency, product quality, and catalyst stability.
[0003] In traditional biopharmaceutical synthesis reaction vessels, stirring rods are typically used to stir and mix drugs dissolved in solvents. Due to the design and movement limitations of the stirring rods, concentration gradients may form in different parts of the solution within the reaction vessel. Some drugs may not be fully wetted or dissolved, resulting in uneven mixing. This uneven mixing state may also lead to a decrease in reaction selectivity, the formation of byproducts, and consequently affect the purity and quality of the product. Utility Model Content
[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a stirring device for a reaction vessel used in biopharmaceutical synthesis.
[0005] To achieve the above objectives, the present invention adopts the following technical solution: A reaction vessel stirring device for biopharmaceutical synthesis includes a cylinder with a cap at the top. Multiple fixing mechanisms for securing the cap are arranged in a circular pattern at equal intervals on the outer wall of the cylinder. An annular seat is fixed at the center of the bottom of the cylinder. A rotating shaft is fitted onto the inner wall of the annular seat. A rotating mechanism for rotating the shaft is located at the bottom of the cap. A stirring mechanism for stirring the drug is located on the side wall of the rotating shaft. A cleaning mechanism for cleaning the inner wall of the cylinder is located inside the cylinder. An annular tube is fitted onto the outer wall of the cylinder. Multiple branch tubes are arranged in a circular pattern at equal intervals on the side wall of the annular tube, one end of each branch tube communicating with the annular tube. The other end of each tube passes through the inner wall of the cylinder. The outer wall of the cylinder is equipped with a conveying mechanism for conveying the drug solution inside the annular tube. An annular baffle is sleeved on the side wall of the rotating shaft, and a circular plate is sleeved on the side wall of the rotating shaft, with the circular plate located on top of the annular baffle. Multiple through holes are opened on the top of the circular plate. During use, the rotating mechanism, in conjunction with the stirring mechanism, performs preliminary stirring and mixing of the drug dissolved in the solvent. At the same time, the conveying mechanism keeps the solution in the cylinder in an alternating flow state, which can accelerate the reaction, increase the product formation rate, further enhance the mixing effect, reduce the formation of by-products, and thus improve the purity and quality of the product.
[0006] As a further embodiment of this utility model, the fixing mechanism includes an L-shaped plate rotatably connected to the outer wall of the cylinder. A circular groove is formed at the top of the L-shaped plate, and a circular block is slidably connected to the inner wall of the circular groove. A connecting rod is fixed to the top of the circular block, with one end of the connecting rod penetrating the top of the L-shaped plate. A spring is sleeved on the side wall of the connecting rod. A circular hole is formed at the top of the cylinder cover, and the hole and the circular block are matched. Multiple L-shaped plates are rotated one by one. During rotation, multiple connecting rods are pulled, causing multiple circular blocks to move upwards along the inner walls of multiple circular grooves until they enter the grooves. At this point, multiple springs are compressed. When the L-shaped plates rotate to a vertical position, the circular grooves and holes overlap. Then, the connecting rods are released, and the reaction force of the compressed springs pushes the circular blocks to move in the opposite direction until they enter the holes, thus completing the fixing of the cylinder and the cylinder cover.
[0007] As a further embodiment of this utility model, the rotating mechanism includes a disc, which is rotatably connected to the middle of the bottom of the cylinder cover. A transmission block is fixed at the bottom of the disc, and a limiting groove is formed at the top of the rotating shaft. The limiting groove and the transmission block are adapted to each other. A motor is fixed at the top of the cylinder cover, and the output shaft of the motor is fixed to the disc through a coupling. The motor drives the transmission block to rotate in conjunction with the disc, and the rotation of the transmission block drives the rotating shaft to rotate in conjunction with the limiting groove.
[0008] As a further embodiment of this utility model, the stirring mechanism includes multiple stirring rods, all of which are fixed to the side wall of the rotating shaft, and are arranged in groups of four. The cleaning mechanism includes multiple arc-shaped scrapers, which are equally spaced and arranged in a circular pattern on the inner wall of the cylinder. Each arc-shaped scraper is fixed to one end of four of the stirring rods. The rotation of the rotating shaft drives the multiple stirring rods to rotate and perform stirring. While stirring, the multiple arc-shaped scrapers move in a circular motion along the inner wall of the cylinder to scrape off and clean the part of the medicine adhering to the inner wall of the cylinder, avoiding the phenomenon of medicine sticking to the wall and preventing the situation where some medicine fails to participate in the reaction due to adhesion to the inner wall of the cylinder, thereby improving the mixing effect.
[0009] As a further embodiment of this utility model, the conveying mechanism includes a water pump, which is fixed to the outer wall of the cylinder and its inlet is connected to the cylinder. The outlet of the water pump is fixed with a connecting pipe, which is connected to the annular pipe. The water pump is driven to draw the solution containing the drug into the annular pipe through the connecting pipe and spray it onto the surface of the circular plate through multiple branch pipes. The solution then falls into the solvent below through multiple through holes, thus forming an alternating circulating flow. This helps to break up large liquid clumps, allowing the solvent and solute to mix more thoroughly, thereby improving the uniformity of the mixture. At the same time, as the sprayed liquid falls back into the container, it can introduce new hydrodynamic effects, increasing the contact area of the substances and thus increasing the reaction rate.
[0010] The beneficial effects of this utility model are as follows: 1. During use, this device uses a rotating mechanism in conjunction with a stirring mechanism to perform preliminary stirring and mixing of the drug dissolved in the solvent. At the same time, the conveying mechanism keeps the solution in the cylinder in an alternating flow state, which can accelerate the reaction, increase the product formation rate, further enhance the mixing effect, reduce the formation of by-products, and thus improve the purity and quality of the product.
[0011] 2. The cleaning mechanism can effectively clean the inner wall of the cylinder, preventing the drug from adhering to the inner wall of the cylinder, so that all drugs have the opportunity to participate in the reaction, thereby improving the comprehensiveness of the reaction.
[0012] 3. The design of the annular seat makes the rotating shaft detachable, allowing the rotating shaft, multiple stirring rods, and multiple arc-shaped scrapers to be removed from the cylinder as a whole, facilitating subsequent cleaning and improving the practicality of the device. Attached Figure Description
[0013] Figure 1 This is a schematic diagram of the structure of a stirring device for a reaction vessel used in biopharmaceutical synthesis according to the present invention; Figure 2This is a schematic cross-sectional view of an L-shaped plate of a stirring device for a reaction vessel used in biopharmaceutical synthesis, as proposed in this utility model. Figure 3 This is a schematic diagram of the conveying mechanism of a stirring device for a reaction vessel used in biopharmaceutical synthesis according to the present invention; Figure 4 This is a cross-sectional view of a cylindrical stirring device for a reaction vessel used in biopharmaceutical synthesis, as proposed in this utility model. Figure 5 This is a schematic diagram of the shaft, stirring rod, arc-shaped scraper, and annular baffle of a reaction vessel stirring device for biopharmaceutical synthesis proposed in this utility model; Figure 6 This is a cross-sectional schematic diagram of the cylinder and cylinder cover of a reaction vessel stirring device for biomedical synthesis proposed in this utility model.
[0014] In the diagram: 1. Cylinder; 2. Cylinder cover; 3. L-shaped plate; 4. Motor; 5. Annular pipe; 6. Branch pipe; 7. Water pump; 8. Connecting pipe; 9. Circular groove; 10. Connecting rod; 11. Circular block; 12. Spring; 13. Circular plate; 14. Through hole; 15. Rotating shaft; 16. Stirring rod; 17. Arc-shaped scraper; 18. Annular baffle; 19. Limiting groove; 20. Annular seat; 21. Disc; 22. Transmission block; 23. Circular hole. Detailed Implementation
[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.
[0016] Reference Figure 1 - Figure 6A reaction vessel stirring device for biopharmaceutical synthesis includes a cylinder 1, a cylinder cover 2 at the top of the cylinder 1, and multiple fixing mechanisms for fixing the cylinder cover 2 arranged in a circular pattern at equal intervals on the outer wall of the cylinder 1. An annular seat 20 is fixed at the center of the bottom of the cylinder 1, and a rotating shaft 15 is sleeved on the inner wall of the annular seat 20. A rotating mechanism for rotating the rotating shaft 15 is provided at the bottom of the cylinder cover 2, and a stirring mechanism for stirring the drug is provided on the side wall of the rotating shaft 15. A cleaning mechanism for cleaning the inner wall of the cylinder 1 is provided inside the cylinder 1. An annular tube 5 is sleeved on the outer wall of the cylinder 1, and multiple branch pipes 6 are arranged in a circular pattern at equal intervals on the side wall of the annular tube 5. One end of each branch pipe 6 is connected to the annular tube 5, and the other end of each branch pipe 6 is connected to the annular tube 5. All ends penetrate the inner wall of the cylinder 1. The outer wall of the cylinder 1 is provided with a conveying mechanism for conveying the drug solution inside the annular tube 5. An annular baffle 18 is sleeved on the side wall of the rotating shaft 15. A circular plate 13 is sleeved on the side wall of the rotating shaft 15, and the circular plate 13 is located on top of the annular baffle 18. Multiple through holes 14 are opened on the top of the circular plate 13. During the use of this device, the rotating mechanism and the stirring mechanism perform preliminary stirring and mixing treatment on the drug dissolved in the solvent. At the same time, the conveying mechanism keeps the solution in the cylinder 1 in an alternating flow state, which can accelerate the reaction, increase the product formation rate, further enhance the mixing effect, reduce the formation of by-products, and thus improve the purity and quality of the product.
[0017] In this embodiment, the fixing mechanism includes an L-shaped plate 3, which is rotatably connected to the outer wall of the cylinder 1. A circular groove 9 is provided at the top of the L-shaped plate 3, and a circular block 11 is slidably connected to the inner side wall of the circular groove 9. A connecting rod 10 is fixed to the top of the circular block 11, and one end of the connecting rod 10 passes through the top of the L-shaped plate 3. A spring 12 is sleeved on the side wall of the connecting rod 10. A circular hole 23 is provided at the top of the cylinder cover 2, and the circular hole 23 is adapted to the circular block 11. By rotating multiple L-shaped plates 3 one by one, multiple connecting rods 10 are pulled respectively, so that multiple Each circular block 11 moves upward along the inner wall of the multiple circular grooves 9 until it enters the interior of the multiple circular grooves 9. At this time, the multiple springs 12 are compressed. When the multiple L-shaped plates 3 rotate to the vertical position, the multiple circular grooves 9 and the multiple circular holes 23 are aligned. At this time, the multiple connecting rods 10 are released. Under the reaction of the multiple compressed springs 12, the multiple circular blocks 11 are pushed to move in the opposite direction until they enter the interior of the multiple circular holes 23, thus completing the fixing of the cylinder 1 and the cylinder cover 2.
[0018] In this embodiment, the rotating mechanism includes a disc 21, which is rotatably connected to the middle of the bottom of the inner part of the cylinder cover 2. A transmission block 22 is fixed at the bottom of the disc 21. A limiting groove 19 is opened at the top of the rotating shaft 15, and the limiting groove 19 and the transmission block 22 are adapted to each other. A motor 4 is fixed at the top of the cylinder cover 2, and the output shaft of the motor 4 is fixed to the disc 21 through a coupling. The drive motor 4 works with the disc 21 to drive the transmission block 22 to rotate. The rotation of the transmission block 22 works with the limiting groove 19 to drive the rotating shaft 15 to rotate.
[0019] In this embodiment, the stirring mechanism includes multiple stirring rods 16, all of which are fixed to the side wall of the rotating shaft 15, and are arranged in groups of four. The cleaning mechanism includes multiple arc-shaped scrapers 17, which are arranged in a circular pattern at equal intervals on the inner wall of the cylinder 1. Each arc-shaped scraper 17 is fixed to one end of four of the stirring rods 16. The rotation of the rotating shaft 15 drives the multiple stirring rods 16 to rotate and perform stirring. While stirring, the multiple arc-shaped scrapers 17 move in a circular motion along the inner wall of the cylinder 1 to scrape and clean the part of the drug adhering to the inner wall of the cylinder 1, so as to avoid the phenomenon of drug hanging on the wall and to prevent the situation where some drugs fail to participate in the reaction due to adhesion to the inner wall of the cylinder 1, thereby improving the mixing effect.
[0020] In this embodiment, the conveying mechanism includes a water pump 7, which is fixed to the outer wall of the cylinder 1. The water inlet of the water pump 7 is connected to the cylinder 1, and the water outlet of the water pump 7 is fixed with a connecting pipe 8, which is connected to the annular pipe 5. The water pump 7 is driven to draw the solution containing the drug into the annular pipe 5 through the connecting pipe 8, and spray it onto the surface of the circular plate 13 through multiple branch pipes 6. Then, it falls into the solvent below through multiple through holes 14, thus forming an alternating circulating flow. This helps to break up large liquid clumps, allowing the solvent and solute to mix more thoroughly, thereby improving the uniformity of the mixture. At the same time, the sprayed liquid can introduce new hydrodynamic effects during the process of falling back into the container, increasing the contact area of the substances and thus increasing the reaction rate.
[0021] Working principle: During use, one end of the rotating shaft 15 is inserted into the annular seat 20, and a certain amount of solvent is placed in the cylinder 1. The drugs to be mixed are poured into the cylinder 1 strictly according to the synthesis ratio, and the cylinder cover 2 is placed on top of the cylinder 1. At this time, the transmission block 22 is located inside the limiting groove 19. As the multiple L-shaped plates 3 are rotated one by one, the multiple connecting rods 10 are pulled, causing the multiple circular blocks 11 to move upward along the inner wall of the multiple circular grooves 9 until the multiple circular blocks 11 enter the multiple circular grooves 9. At this time, the multiple springs 12 are all in a compressed state. When the multiple L-shaped plates 3 are rotated to a vertical state, the multiple circular grooves 9 and Multiple circular holes 23 overlap. At this time, multiple connecting rods 10 are released. Under the reaction action of multiple compressed springs 12, multiple circular blocks 11 are pushed to move in the opposite direction until multiple circular blocks 11 enter the multiple circular holes 23 respectively, thus completing the fixation of cylinder 1 and cylinder cover 2. During mixing, the power switch of motor 4 is turned on, and motor 4, together with disc 21, drives transmission block 22 to rotate. The rotation of transmission block 22, together with limiting groove 19, drives rotating shaft 15 to rotate, thereby driving multiple stirring rods 16 to rotate for stirring. At the same time, multiple arc-shaped scrapers 17 move in a circular motion along the inner wall of cylinder 1 to scrape and clean the part of the medicine adhering to the inner wall of cylinder 1, avoiding the formation of... To prevent drug adhesion to the inner wall of cylinder 1 and ensure that some drugs do not participate in the reaction, thus improving mixing efficiency, the power switch of water pump 7 is turned on while stirring. This drives water pump 7 to draw the solution containing the dissolved drug into the annular pipe 5 through connecting pipe 8, and then sprays it onto the surface of circular plate 13 through multiple branch pipes 6. The solution then falls into the solvent below through multiple through holes 14, creating an alternating circulating flow. This helps break up large liquid clumps, allowing the solvent and solute to mix more thoroughly, thereby improving the uniformity of the mixture. Simultaneously, the process of the sprayed liquid falling back into the container introduces new hydrodynamic effects, increasing the contact area between substances. The mixture is accumulated to increase the reaction rate. After mixing, the mixed solution is removed for further processing. After completion, multiple connecting rods 10 are pulled to move multiple circular blocks 11 upward along the inner walls of multiple circular grooves 9 until the multiple circular blocks 11 enter the multiple circular grooves 9. At this time, the multiple circular blocks 11 and multiple circular holes 23 are separated. Then, multiple L-shaped plates 3 are rotated to separate the multiple L-shaped plates 3 from the cylinder cover 2, that is, to release the fixation of the cylinder cover 2. At this time, the cylinder cover 2 is removed from the top of the cylinder 1, and the rotating shaft 15, multiple stirring rods 16 and multiple arc-shaped scrapers 17 can be removed from the cylinder 1 as a whole, which facilitates subsequent cleaning work and improves the practicality of this device.
[0022] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.
Claims
1. A reaction vessel stirring device for biopharmaceutical synthesis, comprising a cylinder (1), characterized in that, The cylinder (1) is topped with a cap (2). Multiple fixing mechanisms for securing the cap (2) are arranged in a circular pattern at equal intervals on the outer wall of the cylinder (1). An annular seat (20) is fixed at the center of the bottom of the cylinder (1). A rotating shaft (15) is fitted onto the inner wall of the annular seat (20). A rotating mechanism for rotating the rotating shaft (15) is located at the bottom of the cap (2). A stirring mechanism for stirring the medicine is located on the side wall of the rotating shaft (15). A cleaning mechanism for cleaning the inner wall of the cylinder (1) is located inside the cylinder (1). An annular tube (5) is fitted onto the outer wall of the cylinder (1). The annular tube (5) has multiple branch tubes (6) arranged in a circular pattern at equal intervals on its side wall. One end of each branch tube (6) is connected to the annular tube (5), and the other end of each annular tube (5) passes through the inner side wall of the cylinder (1). The outer side wall of the cylinder (1) is provided with a conveying mechanism for conveying liquid medicine into the annular tube (5). The side wall of the rotating shaft (15) is fitted with an annular baffle (18), and the side wall of the rotating shaft (15) is fitted with a circular plate (13). The circular plate (13) is located on top of the annular baffle (18), and the top of the circular plate (13) is provided with multiple through holes (14).
2. The stirring device for a reaction vessel used in biopharmaceutical synthesis according to claim 1, characterized in that, The fixing mechanism includes an L-shaped plate (3), which is rotatably connected to the outer wall of the cylinder (1). A circular groove (9) is provided at the top of the L-shaped plate (3). A circular block (11) is slidably connected to the inner side wall of the circular groove (9). A connecting rod (10) is fixed at the top of the circular block (11), and one end of the connecting rod (10) passes through the top of the L-shaped plate (3). A spring (12) is sleeved on the side wall of the connecting rod (10). A circular hole (23) is provided at the top of the cylinder cover (2), and the circular hole (23) and the circular block (11) are compatible.
3. The stirring device for a reaction vessel used in biopharmaceutical synthesis according to claim 1, characterized in that, The rotating mechanism includes a disc (21), which is rotatably connected to the middle of the bottom of the cylinder cover (2). A transmission block (22) is fixed at the bottom of the disc (21). A limiting groove (19) is opened at the top of the rotating shaft (15), and the limiting groove (19) and the transmission block (22) are adapted to each other. A motor (4) is fixed at the top of the cylinder cover (2), and the output shaft of the motor (4) is fixed to the disc (21) through a coupling.
4. The stirring device for a reaction vessel used in biopharmaceutical synthesis according to claim 1, characterized in that, The stirring mechanism includes multiple stirring rods (16), all of which are fixed on the side wall of the rotating shaft (15), and are arranged in groups of four.
5. The stirring device for a reaction vessel used in biopharmaceutical synthesis according to claim 4, characterized in that, The cleaning mechanism includes multiple arc-shaped scrapers (17), which are arranged in a circular pattern at equal intervals on the inner wall of the cylinder (1), and each arc-shaped scraper (17) is fixed to one end of one of the four stirring rods (16).
6. The stirring device for a reaction vessel used in biopharmaceutical synthesis according to claim 1, characterized in that, The conveying mechanism includes a water pump (7), which is fixed on the outer wall of the cylinder (1) and the water inlet of the water pump (7) is connected to the cylinder (1). The water outlet of the water pump (7) is fixed with a connecting pipe (8) and the connecting pipe (8) is connected to the annular pipe (5).