A filtering device for producing cyclophosphamide injection

Abstract

The utility model relates to liquid filtering and pharmaceutical equipment technical field, specifically disclose a kind of filtering device for cytarabine injection production, including horizontal cylinder, rotatably arranged with filter cartridge in the horizontal cylinder;Horizontal cylinder is provided with raw liquid inlet and filtrate outlet, the raw liquid inlet is located below filter cartridge, and the filtrate outlet is communicated with filter cartridge;Backflushing pipe is coaxially arranged in the filter cartridge, and a plurality of flushing holes are formed on the pipe wall of backflushing pipe, and one end of backflushing pipe penetrates the end of horizontal cylinder and is sealed rotary connection therewith;The structure is delayed filter membrane blockage by filter cartridge rotation centrifugal force to maintain efficient filtration, simultaneously realizes thorough, online cleaning of dead angle using rotary backflushing, and the industry problem of easy blockage, cleaning is not thorough, especially suitable for the production of cytarabine injection with extremely high aseptic requirement.

Description

Technical Field

[0001] This utility model relates to the field of liquid filtration and pharmaceutical equipment technology, and specifically discloses a filtration device for the production of cyclic adenosine monophosphate injections. Background Technology

[0002] As a high-value sterile preparation, the filtration process in the production of cyclic adenosine monophosphate (cAMP) injections is crucial to ensuring product clarity, sterility, and medication safety. Before sterile filtration, the solution often contains trace amounts of proteins, cell debris, and other components that can easily clog the filter membrane, placing extremely high demands on the efficiency and reliability of the filtration device.

[0003] Currently, the filtration devices commonly used in this production field are mostly fixed filter cartridges or filter bags. These traditional devices have the following drawbacks in actual industrial production:

[0004] Firstly, regarding filtration efficiency and anti-clogging capability, the fixed filtration structure makes it extremely easy for solid particles in the liquid to accumulate rapidly on the surface of the filter media, forming a dense "filter cake." This not only leads to a sharp increase in filtration resistance and a rapid decline in throughput, requiring frequent shutdowns to replace filter cartridges, but also severely disrupts production continuity and significantly increases production costs and operational complexity.

[0005] Secondly, the existing cleaning methods for cleaning, maintenance, and aseptic control are extremely inconvenient. For simple filter cartridges, manual cleaning after disassembly is typically required. This method is not only time-consuming and labor-intensive but also introduces significant risks of microbial and particulate contamination during disassembly and reassembly. For equipment with simple backwashing functions, the washing flow path is fixed and the effective area is limited. Especially for cartridge filters, there are numerous cleaning dead zones, resulting in incomplete cleaning. Residual contaminants can become a breeding ground for microorganisms, posing a potential quality threat to subsequent batches of products. Furthermore, although some technical solutions attempt to introduce rotating filter structures to delay clogging, these solutions generally fail to effectively solve the problem of online, efficient, and automated cleaning of the rotating components themselves, particularly the internal area of ​​the filter cartridge, often resulting in unsatisfactory cleaning effects.

[0006] Therefore, those skilled in the art have long been committed to finding an innovative filtration device solution that can effectively overcome the above-mentioned defects and achieve a combination of efficient continuous filtration and thorough online cleaning to meet the needs of high-quality and high-efficiency production of cyclic adenosine monophosphate injections. Utility Model Content

[0007] This invention proposes a filtration device for the production of cyclic adenosine monophosphate (cAMP) injections. Through the coordinated rotation of the filter cartridge and the backwash pipe, it integrates dynamic anti-clogging filtration, dead-angle-free online self-cleaning, and active ultraviolet sterilization functions, thereby significantly improving the filtration efficiency, cleaning thoroughness, and sterility assurance level in the production of cAMP injections.

[0008] This invention is implemented as follows: a filtration device for the production of cyclic adenosine monophosphate injections includes a horizontal cylindrical body, in which a filter cylinder is rotatably disposed; the horizontal cylindrical body is provided with a raw liquid inlet and a filtrate outlet, the raw liquid inlet is located below the filter cylinder, and a flow regulating valve is provided on the raw liquid inlet; the filtrate outlet is connected to the filter cylinder; a backwash pipe is coaxially disposed inside the filter cylinder, the backwash pipe has several flushing holes on its wall, and one end of the backwash pipe passes through the end of the horizontal cylindrical body and is rotatably and sealingly connected thereto; a liquid pump is provided on the outer wall of the horizontal cylindrical body, the inlet of the liquid pump is connected to the pipeline where the filtrate outlet is located through a pipeline, and the outlet is connected to the input end of the backwash pipe through a pipeline;

[0009] It also includes a first drive mechanism and a second drive mechanism disposed on the horizontal cylinder, the first drive mechanism being used to drive the filter cylinder to rotate, and the second drive mechanism being used to drive the backwash pipe to rotate.

[0010] As a preferred embodiment of the filtration device for the production of cyclic adenosine monophosphate injections according to this utility model, the bottom of the horizontal cylinder is provided with a drain port, and a drain valve is provided on the drain port.

[0011] As a preferred embodiment of the filtration device for producing cyclic adenosine monophosphate injections according to this utility model, the first driving mechanism includes a driven gear ring fixed to the outer wall of the filter cylinder, a driving gear meshing with the driven gear ring, and a first motor for driving the driving gear. The first motor is mounted on the outer wall of the horizontal cylinder via a base.

[0012] As a preferred embodiment of the filtration device for the production of cyclic adenosine monophosphate injections according to this utility model, the second drive mechanism includes a driven wheel fixed to the outer wall of the backwash pipe, a drive wheel meshing with the driven wheel, and a second motor for driving the drive wheel. The second motor is mounted on the outer wall of the horizontal cylinder via a base.

[0013] As a preferred embodiment of the filtration device for the production of cyclic adenosine monophosphate injections according to this utility model, the filter medium of the filter cylinder is a double-layer composite filter membrane, with an outer layer pore size of 0.45 μm and an inner layer pore size of 0.22 μm.

[0014] As a preferred embodiment of the filtration device for the production of cyclic adenosine monophosphate injections according to this utility model, at least one ultraviolet germicidal lamp is embedded in the top of the inner wall of the horizontal cylinder; the irradiation range of the ultraviolet germicidal lamp covers the annular gap between the filter cylinder and the inner wall of the horizontal cylinder.

[0015] The beneficial effects of this utility model are:

[0016] 1. The centrifugal force generated by the rotation of the filter cartridge effectively slows down the accumulation of impurities and the formation of "filter cake" on the surface of the filter membrane, significantly reduces filtration resistance, maintains a stable filtration flux, reduces the frequency of downtime for filter replacement, and improves production efficiency.

[0017] 2. By using the clean filtrate produced by this system as the rinsing medium through the independently driven rotary backwash pipe, dynamic and high-pressure rinsing of the inner wall of the filter cartridge is achieved with no dead angles at 360°. The cleaning effect is thorough and solves the problems of inconvenient cleaning and dead angles in traditional devices.

[0018] 3. The entire filtration and cleaning process can be completed automatically without disassembling the equipment, reducing the labor intensity of operators and minimizing human intervention. The setting of the sewage outlet also makes waste liquid discharge more convenient. By irradiating key areas with ultraviolet germicidal lamps, the risk of microbial contamination is actively controlled from the design. Combined with the fully enclosed online cleaning function, the risk of contamination caused by disassembly and cleaning and the equipment itself is minimized, ensuring the production safety of high-requirement drugs such as cyclic adenosine monophosphate injections. Attached Figure Description

[0019] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0020] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0021] Figure 2 This utility model Figure 1 A schematic diagram of the AA-direction structure.

[0022] Figure 3 This is a schematic diagram of the structure of the filter cartridge and backwash pipe of this utility model.

[0023] The markings in the diagram are: 1. Horizontal cylinder; 2. Filter cylinder; 3. Raw material inlet; 4. Filtrate outlet; 5. Flow regulating valve; 6. Backwash pipe; 7. Flushing hole; 8. Pump; 9. First drive mechanism; 10. Second drive mechanism; 11. Drain port; 12. Drain valve; 13. Driven gear ring; 14. Drive gear; 15. First motor; 16. Driven wheel; 17. Drive wheel; 18. Second motor; 19. Base; 20. Ultraviolet germicidal lamp. Detailed Implementation

[0024] The present invention will be further described below with reference to the accompanying drawings and specific embodiments to aid in understanding its content. Unless otherwise specified, the methods used in this invention are conventional methods; the raw materials and apparatus used, unless otherwise specified, are conventional commercially available products.

[0025] Please see Figure 1-3 A filtration device for the production of cyclic adenosine monophosphate injections includes a horizontal cylindrical body 1, a filter cylinder 2 rotatably disposed inside the horizontal cylindrical body 1; a raw liquid inlet 3 and a filtrate outlet 4 are provided on the horizontal cylindrical body 1, the raw liquid inlet 3 is located below the filter cylinder 2, a flow regulating valve 5 is provided on the raw liquid inlet 3, and the filtrate outlet 4 is connected to the filter cylinder 2; a backwash pipe 6 is coaxially disposed inside the filter cylinder 2, a plurality of flushing holes 7 are opened on the pipe wall of the backwash pipe 6, and one end of the backwash pipe 6 passes through the end of the horizontal cylindrical body 1 and is rotatably connected thereto in a sealed manner; a liquid pump 8 is provided on the outer wall of the horizontal cylindrical body 1, the inlet of the liquid pump 8 is connected to the pipeline where the filtrate outlet 4 is located through a pipeline, and the outlet is connected to the input end of the backwash pipe 6 through a pipeline;

[0026] It also includes a first drive mechanism 9 and a second drive mechanism 10 disposed on the horizontal cylinder 1. The first drive mechanism 9 is used to drive the filter cylinder 2 to rotate, and the second drive mechanism 10 is used to drive the backwash pipe 6 to rotate.

[0027] In this embodiment: the raw liquid enters the bottom of the horizontal cylinder 1 through the raw liquid inlet 3 with a flow regulating valve 5 and is submerged in the rotating filter cylinder 2. Under the action of pressure difference, the medicine penetrates the filter medium of the filter cylinder 2 and enters its interior to become the filtrate. At this time, solid impurities are trapped on the outer surface of the filter cylinder 2. At the same time, the first drive mechanism 9 drives the filter cylinder 2 to rotate continuously, using centrifugal force to throw off the solid impurities attached to the filter membrane surface, thereby effectively delaying the formation of the "filter cake layer" and maintaining a stable filtration flux. The filtrate flows out through the filtrate outlet 4. When cleaning is required, the second drive mechanism... The mechanism 10 drives the backwash pipe 6, which is coaxially arranged inside the filter cylinder 2, to rotate. At the same time, the liquid pump 8 draws clean filtrate from the filtrate outlet 4 and pumps it into the backwash pipe 6. The high-pressure liquid is sprayed dynamically at multiple angles through the flushing holes 7 on the pipe wall onto the inner wall of the rotating filter cylinder 2, forming a shearing force that covers the entire filter surface without dead zones. This completely peels off and discharges the pollutants that are blocking the pores of the filter membrane, achieving efficient in-situ cleaning. In addition, the ultraviolet germicidal lamp 20, which is set at the top of the inner wall of the cylinder, continuously sterilizes the space within its irradiation range, further ensuring a sterile environment in the production process.

[0028] As a technical optimization of this utility model, the bottom of the horizontal cylinder 1 is provided with a drain port 11, and a drain valve 12 is provided on the drain port 11.

[0029] In this embodiment, the wastewater containing impurities generated during backwashing can be discharged in a timely manner, preventing impurities from flowing back and contaminating the original liquid or filter cartridge 2. At the same time, the sewage discharge operation is simplified, and the ease of device maintenance is improved.

[0030] As a technical optimization of this utility model, the first drive mechanism 9 includes a driven gear ring 13 fixed to the outer wall of the filter cylinder 2, a drive gear 14 meshing with the driven gear ring 13, and a first motor 15 for driving the drive gear 14. The first motor 15 is mounted on the outer wall of the horizontal cylinder 1 via a base 19.

[0031] In this embodiment: the gear meshing transmission ensures stable rotation of the filter cartridge 2 and efficient power transmission, and the external motor does not come into contact with the liquid medicine, avoiding the risk of contamination and meeting the aseptic requirements of pharmaceutical production.

[0032] As a technical optimization of this utility model, the second drive mechanism 10 includes a driven wheel 16 fixed to the outer wall of the backwash pipe 6, a drive wheel 17 meshing with the driven wheel 16, and a second motor 18 for driving the drive wheel 17. The second motor 18 is mounted on the outer wall of the horizontal cylinder 1 via a base 19.

[0033] In this embodiment, the driven wheel 16, the driving wheel 17, and the second motor 18 provide independent and stable rotational power for the backwash pipe 6, which can flexibly adjust the rinsing angle to ensure thorough rinsing. At the same time, the external motor design meets the cleaning standards of pharmaceutical equipment.

[0034] As a technical optimization of this utility model, the filter medium of the filter cartridge 2 is a double-layer composite filter membrane, with an outer layer pore size of 0.45μm and an inner layer pore size of 0.22μm.

[0035] In this embodiment: the outer layer filters out larger particles first to protect the inner layer; the inner layer achieves precise sterilization. The dual filtration not only ensures the sterility requirements of cyclic adenosine monophosphate injections but also extends the service life of the filter membrane and reduces replacement costs.

[0036] As a technical optimization of this utility model, at least one ultraviolet germicidal lamp 20 is embedded in the top of the inner wall of the horizontal cylinder 1.

[0037] In this embodiment, the internal space and the drug solution can be sterilized in real time, supplementing the aseptic guarantee of the filtration process, preventing the growth of microorganisms, and further meeting the strict aseptic standards for injection production.

[0038] As a technical optimization of this utility model, the irradiation range of the ultraviolet germicidal lamp 20 covers the annular gap between the filter cartridge 2 and the inner wall of the horizontal cylinder 1.

[0039] In this embodiment: ensuring sterilization without dead angles, avoiding residual medicine or impurities in the annular gap from becoming a source of microbial growth, ensuring optimal sterilization effect, and improving the reliability of the device's aseptic guarantee.

[0040] Working principle and usage process of this utility model:

[0041] The first motor 15 is turned on to drive the filter cylinder 2 to rotate. The flow regulating valve 5 of the raw liquid inlet 3 is adjusted to allow the liquid to enter the horizontal cylinder 1. Under pressure, the liquid passes through the rotating filter cylinder 2 from the outside to the inside to complete filtration. The filtrate is collected from the filtrate outlet 4. Impurities are trapped and are less likely to clog the filter membrane due to centrifugal force. When the filtration resistance increases or inter-batch cleaning is required, the rotation of the filter cylinder 2 can be stopped or maintained. The second motor 18 is started to drive the backwash pipe 6 to rotate. At the same time, the liquid pump 8 is started to pump part of the filtrate (or special cleaning solution) into the backwash pipe 6. The high-pressure liquid impacts the inner wall of the filter cylinder 2 from all directions through the rotating flushing hole 7, flushing out the contaminants in the reverse direction. The flushing waste liquid falls to the bottom of the cylinder. After the backwashing is completed, the drain valve 12 at the bottom is opened to discharge the flushing waste liquid and any sediment that may have settled at the bottom of the horizontal cylinder 1 from the system. During the entire production and standby period, the ultraviolet germicidal lamp 20 can be turned on as needed to continuously sterilize the key areas inside the device to prevent the growth of microorganisms.

[0042] In the description of this utility model, it should be understood that the terms "left", "right", "up", "down", "top", "bottom", "front", "back", "inner", "outer", "back", "middle", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0043] However, the above are merely specific embodiments of this utility model and should not be construed as limiting the scope of implementation of this utility model. Therefore, any substitution of equivalent components or equivalent changes and modifications made in accordance with the scope of protection of this utility model should still fall within the scope of the claims of this utility model.

Claims

1. A filtration device for the production of cyclic adenosine monophosphate injections, comprising a horizontal cylindrical body (1), characterized in that: A filter cylinder (2) is rotatably arranged inside the horizontal cylindrical body (1); a raw liquid inlet (3) and a filtrate outlet (4) are provided on the horizontal cylindrical body (1), the raw liquid inlet (3) is located below the filter cylinder (2), a flow regulating valve (5) is provided on the raw liquid inlet (3), and the filtrate outlet (4) is connected to the filter cylinder (2); a backwash pipe (6) is coaxially arranged inside the filter cylinder (2), a plurality of flushing holes (7) are opened on the pipe wall of the backwash pipe (6), and one end of the backwash pipe (6) passes through the end of the horizontal cylindrical body (1) and is sealed and rotatably connected to it; a liquid pump (8) is provided on the outer wall of the horizontal cylindrical body (1), the inlet of the liquid pump (8) is connected to the pipeline where the filtrate outlet (4) is located through a pipeline, and the outlet is connected to the input end of the backwash pipe (6) through a pipeline; It also includes a first drive mechanism (9) and a second drive mechanism (10) disposed on the horizontal cylinder (1), the first drive mechanism (9) being used to drive the filter cylinder (2) to rotate, and the second drive mechanism (10) being used to drive the backwash pipe (6) to rotate.

2. The filtration device for producing cyclic adenosine monophosphate injections according to claim 1, characterized in that: The bottom of the horizontal cylinder (1) is provided with a drain port (11), and a drain valve (12) is provided on the drain port (11).

3. The filtration device for producing cyclic adenosine monophosphate injections according to claim 1, characterized in that: The first drive mechanism (9) includes a driven gear ring (13) fixed to the outer wall of the filter cylinder (2), a drive gear (14) meshing with the driven gear ring (13), and a first motor (15) for driving the drive gear (14). The first motor (15) is mounted on the outer wall of the horizontal cylinder (1) via a base (19).

4. The filtration device for producing cyclic adenosine monophosphate injections according to claim 1, characterized in that: The second drive mechanism (10) includes a driven wheel (16) fixed to the outer wall of the backwash pipe (6), a drive wheel (17) meshing with the driven wheel (16), and a second motor (18) for driving the drive wheel (17). The second motor (18) is mounted on the outer wall of the horizontal cylinder (1) via a base (19).

5. A filtration device for producing cyclic adenosine monophosphate injections according to claim 1, characterized in that: The filter medium of the filter cartridge (2) is a double-layer composite filter membrane with an outer pore size of 0.45 μm and an inner pore size of 0.22 μm.

6. A filtration device for producing cyclic adenosine monophosphate injections according to claim 1, characterized in that: At least one ultraviolet germicidal lamp (20) is embedded in the top of the inner wall of the horizontal cylindrical body (1); the irradiation range of the ultraviolet germicidal lamp (20) covers the annular gap between the filter cylinder (2) and the inner wall of the horizontal cylindrical body (1).

Images