A device for preparing hydrogel microspheres

Abstract

The utility model provides a kind of preparation device of hydrogel microsphere, belong to biological material preparation technical field, it includes frame body, preparation box, syringe and propulsion part;Preparation box is placed on frame body;Syringe is placed on frame body, and is located the upside of preparation box;Propulsion part is located in syringe side, to push out the liquid in syringe;The end of syringe is equipped with scattering part;Scattering part includes fling member and driver;Fling member rotation is equipped in the end of syringe;Driver is equipped in fling member side, and is connected with fling member, to drive fling member to rotate, and then fling member in liquid is thrown out;After liquid in syringe enters scattering part, driver drives fling member to rotate, to throw out the liquid in fling member, cut liquid into small droplet, this process is carried out inside scattering part, and a large amount of liquid splashing does not appear, to save material, convenient to use.

Description

Technical Field

[0001] This invention belongs to the field of biomaterial preparation technology, and more specifically, relates to a device for preparing hydrogel microspheres. Background Technology

[0002] Hydrogel microspheres are functional materials rich in water and with a three-dimensional network structure. They are widely used in biomedicine (drug carriers, cell culture microcarriers), environmental remediation (heavy metal adsorption), food industry (preservative carriers), and other fields. The performance of the preparation device directly determines the key indicators of microspheres such as particle size distribution, mechanical strength, and porosity.

[0003] Currently, Chinese patent number 202421687856.6 discloses a device for preparing hydrogel microspheres. In this device, a hydrogel precursor liquid is uniformly ejected through a syringe needle and then cut into fine droplets by a hydrogel microsphere cutter. These droplets fall into colorless mineral oil or vegetable oil in a hydrogel microsphere collection tank, forming water-in-oil emulsion droplets. Under curing light, the water-in-oil emulsion droplets settle into the aqueous phase below the colorless mineral oil or vegetable oil, forming solidified hydrogel microspheres. The microspheres are then discharged from the bottom outlet pipe by a circulating water flow and collected on a filter screen at the outlet pipe, achieving the technical effect of easily preparing hydrogel microspheres of uniform size. While this device achieves the above effect, the metal wire cutting the hydrogel precursor liquid into fine droplets generates a large amount of splashing, resulting in a significant amount of hydrogel precursor liquid being ejected from the hydrogel microsphere collection tank, causing waste and inconvenience.

[0004] In view of this, the applicant applies for the design of a device for preparing hydrogel microspheres. Utility Model Content

[0005] The purpose of this invention is to provide a device for preparing hydrogel microspheres, in order to solve the technical problem in the prior art that after metal filaments cut the hydrogel precursor liquid stream into tiny droplets, a large amount of splashing occurs, resulting in waste and inconvenience.

[0006] To achieve the above objectives, the technical solution adopted by this utility model is: to provide an apparatus for preparing hydrogel microspheres, comprising: Framework; The preparation box is placed on the frame body; The syringe is placed on the frame and located on the upper side of the preparation box; A propulsion section, located on one side of the syringe, is used to push out the liquid inside the syringe; The syringe has a scattering part at its end; The scattering part includes: A swiveling element is rotatably located at the end of the syringe; A driver is located on one side of the swinging member and connected to the swinging member to drive the swinging member to rotate, thereby throwing out the liquid inside the swinging member.

[0007] In one possible implementation, based on the above technical solutions, the frame includes a first upright plate, a second upright plate, and a base plate. The first upright plate is connected to the base plate, and the second upright plate is also connected to the base plate. Lifting holes are provided on the first upright plate and the second upright plate.

[0008] In one possible implementation, based on the above technical solutions, the preparation box is cylindrical and placed on the base plate, with a support plate connecting the first and second upright plates, and the syringe is fixedly installed on one side of the support plate.

[0009] In one possible implementation, based on the above technical solutions, the propulsion unit includes a propeller and a piston body. The propeller is fixedly installed on the other side of the support plate, and the piston body is disposed on the output end of the propeller. The support plate has a propulsion hole, and the output end of the propeller passes through the propulsion hole, thereby driving the piston body to move inside the syringe.

[0010] In one possible implementation, based on the above technical solutions, the agitator includes a fixed end cap and a rotating cylinder. The fixed end cap is fixedly disposed on one side of the end of the syringe, and the rotating cylinder is rotatably disposed on the fixed end cap. The end of the syringe passes through the fixed end cap and is placed inside the rotating cylinder. The bottom surface of the rotating cylinder is a conical surface, and ejection holes are provided on the conical surface.

[0011] In one possible implementation, based on the above technical solutions, the fixed end cap is provided with two support columns, one end of which is fixedly connected to the fixed end cap and the other end is fixedly connected to the support plate, thereby fixing the scattering part to the end of the syringe.

[0012] In one possible implementation, based on the above technical solutions, a bearing is fixed to one side of the fixed end cap, and the rotating cylinder is fixed to the bearing, thereby enabling it to rotate around the fixed end cap.

[0013] In one possible implementation, based on the above technical solutions, the rotating cylinder has a first slot, the output end of the driver is connected to a rotating plate, the rotating plate has a second slot, and belts are fitted onto the first slot and the second slot.

[0014] In one possible implementation, based on the above technical solutions, the preparation box is connected to an inlet pipe on one side and an outlet pipe on the other side; the outlet pipe is connected to a distribution pipe, and filter cartridges are installed at both ends of the distribution pipe. Filter screens are installed inside the filter cartridges, and flow switches are installed on both sides of the distribution pipe to control the flow of water.

[0015] In conjunction with the above technical solutions, in one possible implementation, a photocuring irradiator is also placed at the bottom of the preparation box.

[0016] The beneficial effects of the hydrogel microsphere preparation device provided by this utility model are as follows: Compared with the prior art, the preparation device provided by this utility model includes a frame body, a preparation box, a syringe, and a propulsion part. The preparation box is placed on the frame body, and the syringe is also placed on the frame body and located on the upper side of the preparation box. The propulsion part is located on one side of the syringe and is used to cooperate with the syringe to push out the liquid in the syringe. In addition, this device also provides a scattering part at the end of the syringe. The scattering part includes a flail and a driver. The flail wraps around the end of the syringe. After the liquid in the syringe enters the scattering part, the driver drives the flail to rotate, thereby flinging out the liquid in the flail and cutting the liquid into fine droplets. This process is carried out inside the scattering part, and there will be no large amount of liquid splashing, thus saving materials and facilitating use. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 A schematic diagram of the structure of the hydrogel microsphere preparation device provided in this embodiment of the present invention; Figure 2 An exploded view of the propulsion unit and syringe of the hydrogel microsphere preparation device provided in this embodiment of the present invention, when mounted on the support plate; Figure 3 An exploded view of the agitator of the hydrogel microsphere preparation apparatus provided in this embodiment of the present invention.

[0019] The labels for the attached figures are as follows: 100. Frame structure; 110. First upright panel; 120. Second upright panel; 130. Base plate; 140. Lifting hole; 150. Support plate; 151. Pushing hole; 200. Preparation box; 210. Inlet pipe; 220. Outlet pipe; 221. Divider pipe; 222. Filter cartridge; 223. Flow switch; 300. Syringe; 400. Propulsion section; 410. Propulsion device; 420. Piston body; 500. Scattering part; 510. Thrusting component; 511. Fixed end cap; 5111, Support column; 5112, Bearing; 512, Rotating cylinder; 5121, Conical surface; 5122, ejection hole; 5123, first empty slot; 520, driver; 521, rotating plate; 5211, Second empty slot; 530, Belt; 600, Photocuring irradiator. Detailed Implementation

[0020] To make the technical problem to be solved, the technical solution, and the beneficial effects of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the described embodiments are only a part of the embodiments of this application, not all of them. The specific embodiments described herein are only used to explain this utility model and are not intended to limit this utility model. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0021] It should be further explained that the accompanying drawings and embodiments of this utility model mainly describe the concept of this utility model. Based on this concept, some specific forms and settings of connection relationships, positional relationships, power mechanisms, power supply systems, hydraulic systems and control systems may not be fully described. However, under the premise that those skilled in the art understand the concept of this utility model, they can implement the above-mentioned specific forms and settings in a well-known manner.

[0022] When a component is referred to as being "fixed to" or "set on" another component, it can be directly on or indirectly on that other component. When a component is referred to as being "connected to" another component, it can be directly connected to or indirectly connected to that other component.

[0023] The directional terms "inner" and "outer" refer to the inner and outer sides relative to the outline of each component itself. The terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0024] For ease of description, spatial relative terms such as "above," "over," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation beyond the orientation of the device as described in the figures. For example, if the device in the figures were inverted, a device described as "above" or "above" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways, and the spatial relative descriptions used herein will be interpreted accordingly.

[0025] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "multiple" means two or more, and "several" means one or more, unless otherwise explicitly specified.

[0026] The present invention provides a device for preparing hydrogel microspheres.

[0027] like Figures 1 to 3As shown, this utility model provides a device for preparing hydrogel microspheres, including a frame body 100, a preparation box 200, a syringe 300, and a propulsion part 400; the preparation box 200 is placed on the frame body 100; the syringe 300 is placed on the frame body 100 and located above the preparation box 200. A light-shielding layer (not shown) and a temperature-controlling layer (not shown) are sleeved around the syringe 300. The light-shielding layer prevents premature cross-linking of the hydrogel precursor fluid, and the temperature-controlling layer is used to reach the target temperature and maintain a constant temperature, allowing the hydrogel to... The pre-gel fluid remains in a liquid state; the propulsion part 400 is provided on one side of the syringe 300 to push out the liquid in the syringe 300; wherein, the end of the syringe 300 is provided with a scattering part 500; the scattering part 500 includes a flinging member 510 and a driver 520; the flinging member 510 is rotatably provided on the end of the syringe 300; the driver 520 is provided on one side of the flinging member 510 and connected to the flinging member 510 to drive the flinging member 510 to rotate, thereby flinging out the liquid in the flinging member 510.

[0028] like Figure 1 As shown, in a specific embodiment of the hydrogel microsphere preparation device provided in this utility model, a water inlet pipe 210 is connected to one side of the preparation box 200, and a water outlet pipe 220 is connected to the other side.

[0029] The preparation box 200 contains a water flow layer and a colorless mineral oil or vegetable oil layer. The water flow layer is located below the colorless mineral oil or vegetable oil layer. The inlet pipe 210 and the outlet pipe 220 are both located in the water flow layer. The hydrogel precursor solution in this application refers to a solution prepared by dissolving photosensitive biomaterials in water, followed by the addition of a crosslinking initiator, and then dispersing the bioactive substances and / or nanoparticles in the aqueous solution to obtain the hydrogel precursor solution. Specifically, the crosslinking initiator is lithium phenyl-2,4,6-trimethylbenzoylphosphonate; the final concentration of the crosslinking initiator is 0.1%; and the raw materials can be one or a combination of several of methacrylamide gelatin, methacrylamide chitosan, and methacrylic anhydride-modified hyaluronic acid.

[0030] This invention provides a device for preparing hydrogel microspheres. Compared with the prior art, the device includes a frame 100, a preparation box 200, a syringe 300, and a propulsion unit 400. The preparation box 200 is placed on the frame 100, and the syringe 300 is also placed on the frame 100, located above the preparation box 200. A propulsion unit 410 is located on one side of the syringe 300 to cooperate with the syringe 300, thereby pushing out the liquid inside the syringe 300. The device also provides a scattering section 500 at the end of the syringe 300. The scattering section 500 includes a flinger 510 and a driver 520. The flinger 510 wraps around the end of the syringe 300. After the liquid in the syringe 300 enters the scattering section 500, the driver 520 drives the flinger 510 to rotate, thereby flinging out the liquid in the flinger 510 and cutting the liquid into fine droplets. This process takes place inside the scattering section 500, which prevents a large amount of liquid splashing, thus saving materials and making it convenient to use.

[0031] like Figure 1 As shown, in a specific embodiment of the hydrogel microsphere preparation device provided in this utility model, the frame body 100 includes a first upright plate 110, a second upright plate 120 and a bottom plate 130. The first upright plate 110 is connected to the bottom plate 130, and the second upright plate 120 is also connected to the bottom plate 130. Pull-up holes 140 are provided on the first upright plate 110 and the second upright plate 120.

[0032] Specifically, this device is equipped with a first upright plate 110 and a second upright plate 120, and lifting holes 140 are provided on the first upright plate 110 and the second upright plate 120. When moving this device, it can be easily moved by holding the lifting holes 140 with both hands, which improves convenience compared to a structure with only a single upright plate.

[0033] like Figure 1 and Figure 2 As shown, in a specific embodiment of the hydrogel microsphere preparation device provided in this utility model, the preparation box 200 is cylindrical and placed on the base plate 130. A support plate 150 is connected between the first vertical plate 110 and the second vertical plate 120. A syringe 300 is fixedly installed on one side of the support plate 150. The propulsion part 400 includes a propeller 410 and a piston body 420. The propeller 410 is fixedly installed on the other side of the support plate 150. The piston body 420 is located on the output end of the propeller 410. A propulsion hole 151 is opened on the support plate 150. The output end of the propeller 410 passes through the propulsion hole 151, thereby driving the piston body 420 to move inside the syringe 300.

[0034] It should be explained in detail that when preparing hydrogel microspheres, hydrogel precursor liquid needs to be injected into syringe 300 to control the output end of pusher 410 to move downward. The downward movement of its output end will drive the piston 420 connected to it to move downward within syringe 300, thereby enabling the hydrogel precursor liquid to be pushed out through the outlet of syringe 300. The pusher 410 in this device can be a hydraulic cylinder or an electric push rod, etc.

[0035] like Figure 3 As shown, in a specific embodiment of the hydrogel microsphere preparation device provided in this utility model, the agitator 510 includes a fixed end cap 511 and a rotating cylinder 512. The fixed end cap 511 is fixedly disposed on one side of the end of the syringe 300, and the rotating cylinder 512 is rotatably disposed on the fixed end cap 511. The end of the syringe 300 passes through the fixed end cap 511 and is placed inside the rotating cylinder 512. The bottom surface of the rotating cylinder 512 is a conical surface 5121, and the conical surface 5121 is provided with ejection holes 5122. A photocuring irradiator 600 is also placed at the bottom of the preparation box 200. During the preparation process, the photocuring irradiator 600 maintains the irradiation working state.

[0036] After the hydrogel precursor liquid comes out of the syringe 300, it falls onto the conical surface 5121 inside the rotating cylinder 512. Then, under the rapid rotation of the rotating cylinder 512, the hydrogel precursor liquid is cut into tiny droplets by the ejection hole 5122 on the conical surface 5121 and ejected under centrifugal force, thus falling into the colorless mineral oil or vegetable oil layer to form water-in-oil emulsion droplets. During this process, the hydrogel precursor liquid is confined within the ejector 510 and will not leave the ejector 510. Under the irradiation of curing light, the water-in-oil emulsion droplets settle into the aqueous phase below the colorless mineral oil or vegetable oil to form solidified hydrogel microspheres. Then, under the flow of circulating water, the hydrogel microspheres are discharged from the bottom outlet pipe 220 and finally collected on the filter screen at the outlet of the outlet pipe 220.

[0037] like Figure 1 As shown, in a specific embodiment of the hydrogel microsphere preparation device provided in this utility model, the fixed end cap 511 is provided with two support columns 5111. One end of the support column 5111 is fixedly connected to the fixed end cap 511, and the other end is fixedly connected to the support plate 150, so that the scattering part 500 is fixed to the end of the syringe 300. The fixed connection can be a threaded connection or an adhesive connection, etc.

[0038] like Figure 3 As shown, in a specific embodiment of the hydrogel microsphere preparation device provided in this utility model, a bearing 5112 is fixed on one side of the fixed end cap 511, and the rotating cylinder 512 is fixed on the bearing 5112, so that it can rotate around the fixed end cap 511.

[0039] Specifically, in order to ensure that the rotating cylinder 512 can rotate, the rotating cylinder 512 is connected to the fixed end cover 511 by a bearing 5112, so that the rotating cylinder 512 can rotate flexibly on the fixed end cover 511.

[0040] like Figure 2 and Figure 3 As shown, in a specific embodiment of the hydrogel microsphere preparation device provided in this utility model, a first slot 5123 is provided on the rotating cylinder 512, a rotating plate 521 is connected to the output end of the driver 520, a second slot 5211 is provided on the rotating plate 521, and a belt 530 is sleeved on the first slot 5123 and the second slot 5211.

[0041] Specifically, when the rotating cylinder 512 needs to be rotated, the driver 520 is started. The driver 520 is a motor, and the output end of the driver 520 will rotate, thereby driving the rotating plate 521 connected to it to rotate. Finally, the rotating cylinder 512 is driven to rotate through the belt 530, thereby realizing the cutting of the hydrogel precursor fluid.

[0042] like Figure 1 As shown, in a specific embodiment of the hydrogel microsphere preparation device provided in this utility model, the water outlet pipe 220 is connected to the water distribution pipe 221, and filter cylinders 222 are installed at both ends of the water distribution pipe 221. The filter cylinders 222 are provided with filter screens, and flow switches 223 are installed on both sides of the water distribution pipe 221 to control the flow of water.

[0043] Furthermore, in this device, the outlet pipe 220 is connected to the distribution pipe 221. The distribution pipe 221 has two ends, both of which are threadedly connected to filter cartridges 222. Flow switches 223 are provided on both sides of the distribution pipe 221. By setting this structure, the preparation of hydrogel microspheres can be carried out continuously. The specific operation is as follows: First, close one flow switch 223 and open the other flow switch 223. The hydrogel microspheres will then enter the filter cartridge 222 on the side where the flow switch 223 is open. When the filter cartridge 222 is full, close the open flow switch 223 and open the other closed flow switch 223. At this time, the hydrogel microspheres will change direction and enter the filter cartridge 222 on the side where the flow switch 223 was just opened, thereby realizing the continuous preparation of hydrogel microspheres.

[0044] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

[0045] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0046] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps described in these embodiments do not limit the scope of this application. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following drawings denote similar items; therefore, once an item is defined in one drawing, it need not be further discussed in subsequent drawings.

Claims

1. An apparatus for preparing hydrogel microspheres, characterized in that, include: Frame (100); The preparation box (200) is placed on the frame body (100); A syringe (300) is placed on the frame body (100) and located on the upper side of the preparation box (200); A propulsion section (400) is provided on one side of the syringe (300) for pushing out liquid from the syringe (300); The syringe (300) is provided with a scattering part (500) at its end. The scattering section (500) includes: A swinging member (510) is rotatably disposed at the end of the syringe (300); A driver (520) is located on one side of the swing member (510) and connected to the swing member (510) to drive the swing member (510) to rotate, thereby throwing out the liquid inside the swing member (510).

2. The apparatus for preparing hydrogel microspheres as described in claim 1, characterized in that: The frame (100) includes a first upright plate (110), a second upright plate (120) and a base plate (130). The first upright plate (110) is connected to the base plate (130), and the second upright plate (120) is also connected to the base plate (130). Lifting holes (140) are provided on the first upright plate (110) and the second upright plate (120).

3. The apparatus for preparing hydrogel microspheres as described in claim 2, characterized in that: The preparation box (200) is cylindrical and placed on the base plate (130). A support plate (150) is connected between the first upright plate (110) and the second upright plate (120). The syringe (300) is fixedly installed on one side of the support plate (150).

4. The apparatus for preparing hydrogel microspheres as described in claim 3, characterized in that: The propulsion unit (400) includes a propeller (410) and a piston body (420). The propeller (410) is fixedly installed on the other side of the support plate (150). The piston body (420) is located on the output end of the propeller (410). The support plate (150) has a propulsion hole (151). The output end of the propeller (410) passes through the propulsion hole (151), thereby driving the piston body (420) to move inside the syringe (300).

5. The apparatus for preparing hydrogel microspheres as described in claim 3, characterized in that: The flailing component (510) includes a fixed end cap (511) and a rotating cylinder (512). The fixed end cap (511) is fixedly disposed on one side of the end of the syringe (300). The rotating cylinder (512) is rotatably disposed on the fixed end cap (511). The end of the syringe (300) passes through the fixed end cap (511) and is placed inside the rotating cylinder (512). The bottom surface of the rotating cylinder (512) is a conical surface (5121), and flail holes (5122) are provided on the conical surface (5121).

6. The apparatus for preparing hydrogel microspheres as described in claim 5, characterized in that: The fixed end cap (511) is provided with two support columns (5111). One end of the support column (5111) is fixedly connected to the fixed end cap (511), and the other end is fixedly connected to the support plate (150), so that the scattering part (500) is fixed to the end of the syringe (300).

7. The apparatus for preparing hydrogel microspheres as described in claim 6, characterized in that: A bearing (5112) is fixed on one side of the fixed end cap (511), and the rotating cylinder (512) is fixed on the bearing (5112), so that it can rotate around the fixed end cap (511).

8. The apparatus for preparing hydrogel microspheres as described in claim 7, characterized in that: The rotating cylinder (512) has a first slot (5123), the output end of the driver (520) is connected to a rotating plate (521), the rotating plate (521) has a second slot (5211), and belts (530) are sleeved on the first slot (5123) and the second slot (5211).

9. The apparatus for preparing hydrogel microspheres as described in claim 8, characterized in that: The preparation box (200) is connected to an inlet pipe (210) on one side and an outlet pipe (220) on the other side; the outlet pipe (220) is connected to a distribution pipe (221), and filter cartridges (222) are installed at both ends of the distribution pipe (221). The filter cartridges (222) are equipped with filter screens, and flow switches (223) are installed on both sides of the distribution pipe (221) to control the flow of water.

10. The apparatus for preparing hydrogel microspheres as described in claim 1, characterized in that: A photocuring irradiator (600) is also placed at the bottom of the preparation box (200).

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