Circuit module, cell micropuncture device, and microscope system

Abstract

To provide a circuit module in which safety when supplying voltage to circuit elements is improved.SOLUTION: A circuit module 30 for outputting voltage to a circuit element 16b1, comprises: a first connector 31 which is arranged on the circuit element 16b1 side; a second connector 32 which is arranged on the opposite side of the first connector 31; a cable 33 which connects the first connector 31 with the second connector 32; a first confirmation part which changes a state when the first connector 31 or the second connector 32 and the cable 33 become a non-connection state; a second confirmation part which changes a state when the first connector 31 or the second connector 32 and the cable 33 become a non-connection state; a first interruption part 34 which contributes to voltage interruption corresponding to changes of the state of the first confirmation part; and a second interruption part 37 which contributes to voltage interruption corresponding to changes of the state of the second confirmation part.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present disclosure relates to a circuit module, a cell puncture device, and a microscope system. [Background technology]

[0002] In the past, in research and application development related to cells, there have been known techniques for inserting a needle into a cell in order to precisely inject a drug solution or the like into a specific sample cell or to aspirate a substance inside the cell. For example, Patent Document 1 discloses a device using a multi-barrel nanopipette with at least two electrodes in multiple barrels, in which one barrel withdraws the cell contents and the other barrel injects a substance into the cell. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 6453300 Summary of the Invention [Problem to be solved by the invention]

[0004] Conventional cell puncture devices use circuit elements such as piezoelectric elements to puncture cells with a needle, but even Patent Document 1 did not fully consider the safety of supplying voltage to these circuit elements.

[0005] An object of the present disclosure is to provide a circuit module, a cell puncture device, and a microscope system that improve safety when supplying voltage to circuit elements. [Means for solving the problem]

[0006] In some embodiments, the circuit module is a circuit module that outputs a voltage to a circuit element, and includes a first connector arranged on the circuit element side, a second connector arranged on the opposite side of the first connector, a cable connecting the first connector and the second connector, a first confirmation unit that changes its state when the first connector or the second connector and the cable become disconnected, a second confirmation unit that changes its state when the first connector or the second connector and the cable become disconnected, a first blocking unit that contributes to blocking the voltage in response to the change in state of the first confirmation unit, and a second blocking unit that contributes to blocking the voltage in response to the change in state of the second confirmation unit.

[0007] This improves safety when supplying voltage to the circuit elements. By having the first confirmation unit and the first cut-off unit, the circuit module can contribute to cutting off the voltage to the circuit elements at one location when the cable is not connected to at least one of the first connector and the second connector. By having the second confirmation unit and the second cut-off unit, the circuit module can contribute to cutting off the voltage to the circuit elements at another location when the cable is not connected to at least one of the first connector and the second connector. As described above, the circuit module can contribute to cutting off the voltage at multiple locations when the cable is not connected, and can more reliably suppress voltage output.

[0008] In one embodiment, the first check unit may include a first wiring looping between the first cutoff unit and the first connector via the second connector and the cable. This allows the circuit module to directly cut off voltage to the circuit elements in response to a change in the conduction state of the first wiring. Therefore, the circuit module can more reliably suppress voltage output when the cable is disconnected.

[0009] In one embodiment, the second check unit may include a second wiring looped between the second cutoff unit and the first connector via the second connector and the cable. This allows the circuit module to indirectly cut off voltage to the circuit elements in response to a change in the conduction state of the second wiring. Therefore, the circuit module can more reliably suppress voltage output when the cable is disconnected.

[0010] In one embodiment, the circuit module may include a first communication element disposed at a first connection portion between the cable and the first connector, which detects the disconnected state between the first connector and the cable and outputs a first communication signal to the first blocking portion, and a second communication element disposed at a second connection portion between the cable and the second connector, which detects the disconnected state between the second connector and the cable and outputs a second communication signal to the first blocking portion.

[0011] This allows the circuit module to directly cut off the voltage to the circuit elements in response to changes in the output state of the communication signal from each communication element, thereby more reliably suppressing voltage output when the cable is disconnected.

[0012] In one embodiment, the circuit module may include a third communication element disposed at a third connection portion between the cable and the first connector, which detects the non-connected state between the first connector and the cable and outputs a third communication signal to the second blocking portion, and a fourth communication element disposed at a fourth connection portion between the cable and the second connector, which detects the non-connected state between the second connector and the cable and outputs a fourth communication signal to the second blocking portion.

[0013] This allows the circuit module to indirectly cut off the voltage to the circuit elements in response to changes in the output state of the communication signal from each communication element, thereby more reliably suppressing the voltage output when the cable is disconnected.

[0014] In one embodiment, the circuit module may further include a converter disposed on the second connector side and configured to convert a low-voltage signal input to the circuit module into a high-voltage signal for driving the circuit element, thereby enabling the circuit module to easily drive the circuit element even when a high voltage is required to drive the circuit element.

[0015] In one embodiment, the first cutoff unit may be disposed between the conversion unit and the second connector and cut off the high-voltage signal output from the conversion unit, thereby enabling the circuit module to directly cut off voltage to circuit elements using the first cutoff unit.

[0016] In one embodiment, the second cutoff unit may be disposed between a power supply line from outside the circuit module and the conversion unit, and cut off the power supply to the conversion unit. This allows the circuit module to indirectly cut off the voltage to the circuit elements by means of the second cutoff unit.

[0017] In one embodiment, the second cutoff unit may be disposed between a signal line from outside the circuit module and the conversion unit, and may cut off the low-voltage signal input to the conversion unit. This allows the circuit module to indirectly cut off voltage to circuit elements using the second cutoff unit. By performing double cutoff using the second cutoff unit and the first cutoff unit when the cable is disconnected, the circuit module can more reliably suppress the output of high-voltage signals, improving safety.

[0018] In one embodiment, the circuit module further includes a third cut-off unit that contributes to cutting off the voltage in response to a change in the state of the first confirmation unit, and the third cut-off unit is arranged between a power supply line from outside the circuit module and the first cut-off unit, and may cut off the power supply to the first cut-off unit, cutting off or uncutting the first cut-off unit.

[0019] This allows the circuit module to indirectly cut off the voltage to the circuit elements by the third cutoff unit. By further including the third cutoff unit, the circuit module can perform cutoff using three cutoff units when the cable is in a disconnected state. The circuit module can perform doubly cutting off on the low-voltage side by the second and third cutoff units, in addition to the first cutoff unit that must be selected as one usable at high voltages. Therefore, the circuit module can more reliably suppress the output of high-voltage signals, improving safety.

[0020] A cell puncture device according to some embodiments includes the circuit module described above, the circuit element, and a needle that is driven by the circuit element and punctures a cell.

[0021] This improves safety when supplying voltage to the circuit element. By having a first confirmation unit and a first cut-off unit, the cell puncturing device can contribute to cutting off the voltage to the circuit element at one location when the cable is not connected to at least one of the first connector and the second connector. By having a second confirmation unit and a second cut-off unit, the cell puncturing device can contribute to cutting off the voltage to the circuit element at another location when the cable is not connected to at least one of the first connector and the second connector. As described above, the cell puncturing device can contribute to cutting off the voltage at multiple locations when the cable is not connected, and can more reliably suppress voltage output.

[0022] In one embodiment of the cell puncturing device, the circuit element may include a piezoelectric element. This allows the cell puncturing device to move the needle at high speed when puncturing a cell. Therefore, the cell puncturing device can easily control the position and speed of the needle tip so that it penetrates the cell wall in order to inject a drug solution into the cell or to aspirate and extract substances from inside the cell. By combining a circuit module with a piezoelectric element, the cell puncturing device can improve safety even against voltages applied to the piezoelectric element, which can be as high as 150 V.

[0023] A microscope system according to some embodiments includes the cell puncture device described above.

[0024] This improves safety when supplying voltage to the circuit elements. By having the first confirmation unit and the first cut-off unit, the microscope system can contribute to cutting off the voltage to the circuit elements at one location when the cable is not connected to at least one of the first connector and the second connector. By having the second confirmation unit and the second cut-off unit, the microscope system can contribute to cutting off the voltage to the circuit elements at another location when the cable is not connected to at least one of the first connector and the second connector. As described above, the microscope system can contribute to cutting off the voltage at multiple locations when the cable is in a disconnected state, and can more reliably suppress voltage output. [Effects of the Invention]

[0025] According to the present disclosure, it is possible to provide a circuit module, a cell puncture device, and a microscope system that improve safety when supplying voltage to a circuit element. [Brief explanation of the drawings]

[0026] [Figure 1] 1 is a schematic diagram showing an example of the configuration of a microscope system having a cell puncturing device according to a first embodiment of the present disclosure. [Figure 2]1 is a schematic diagram illustrating an example of the configuration of a circuit module according to a first embodiment of the present disclosure. [Figure 3] FIG. 10 is a schematic diagram illustrating an example of the configuration of a circuit module according to a second embodiment of the present disclosure. [Figure 4] FIG. 10 is a schematic diagram showing an example of the configuration of a circuit module according to a first modified example of the present disclosure. [Figure 5] FIG. 10 is a schematic diagram showing an example of the configuration of a circuit module according to a second modified example of the present disclosure. DETAILED DESCRIPTION OF THE INVENTION

[0027] The background and problems of the prior art will now be described in more detail.

[0028] In recent years, in research on biological systems, for example, studies have been conducted to elucidate cellular functions by injecting specific chemical solutions into cells and observing changes in the cells, or to induce specific modifications in specific cells by injecting chemical solutions for genetic modification into cells. In addition, application development aimed at application to the production of chemical solutions and the like has also been conducted. Meanwhile, research has also been conducted to elucidate cellular functions and application development aimed at application to production by aspirating and recovering some of the components that make up specific cells. In such research and application development, for example, it is necessary to accurately inject chemical solutions into specific cells or aspirate components from specific cells, and a cell puncturing device that can accurately puncture cells with a needle is desired.

[0029] Patent Document 1 discloses a conventional method and device for injecting a drug solution into a cell by controlling the position of a fine needle with a piezoelectric element, puncturing the cell with the needle tip, and controlling the voltage. Similarly, the patent document also discloses a conventional method and device for aspirating a substance from inside a cell.

[0030] Generally, cells have a cell wall located at the outermost part of the cell, which covers and protects the interior of the cell. Therefore, in order to inject a chemical solution into the cell or to aspirate and extract a substance from inside the cell, the cell puncturing device must control the position and speed of the needle tip to insert the needle into the cell so that the needle tip penetrates the cell wall. To achieve this, it is preferable for the cell puncturing device to move the needle at a high speed when puncturing the cell.

[0031] For example, the cell puncture device can penetrate the cell wall of certain animal cells with soft cell walls even when the needle is moved slowly, whereas the cell puncture device has a problem in that the needle does not penetrate the cell wall of certain plant cells with hard cell walls unless the needle is moved quickly, making it difficult to insert the needle tip into the cell.

[0032] As described above, one known method for moving the needle at high speed is to use a circuit element such as a piezoelectric element to move the needle. When a voltage is applied to a piezoelectric element, an electrostrictive effect occurs internally, causing the piezoelectric element itself to expand and contract. The expansion and contraction of a piezoelectric element can respond more quickly than actuators such as general motors. Therefore, the cell puncture device uses the piezoelectric element to enable the needle to puncture a cell at high speed.

[0033] However, the expansion and contraction caused by the electrostrictive effect of the piezoelectric element is minute compared to the applied voltage. To obtain sufficient expansion and contraction to move the needle, a high voltage must be applied to the piezoelectric element. For example, the voltage applied to the piezoelectric element can be as high as 150 V. Therefore, if a high voltage is output from the controller when the wiring from the controller that controls the device to the drive unit containing the piezoelectric element is not fastened, there is a possibility that an operator could be exposed to high voltage when touching the unfastened part.

[0034] In order to solve the above problems, an object of the present disclosure is to provide a circuit module, a cell puncture device, and a microscope system that improve safety when supplying voltage to circuit elements.

[0035] An embodiment of the present disclosure will be mainly described below with reference to the accompanying drawings. In the following description, the x, y, and z directions are based on the directions of the arrows in the drawings.

[0036] (First embodiment) FIG. 1 is a schematic diagram showing an example of the configuration of a microscope system 1 including a cell puncturing device 10 according to a first embodiment of the present disclosure. For the purpose of simplifying the illustration, FIG. 1 shows only a schematic representation of part of the configuration of the cell puncturing device 10, omitting components such as a circuit module 30, which will be described later. An example of the configuration and function of the microscope system 1 including the cell puncturing device 10 according to the first embodiment will be mainly described with reference to FIG. 1. The microscope system 1 includes the cell puncturing device 10 and a microscope 20 that captures an image of a cell S punctured by a needle 17a of the cell puncturing device 10.

[0037] The microscope 20 includes any microscope capable of photographing the cell S. The microscope 20 includes, for example, a confocal microscope. The microscope 20 has any camera 21 capable of photographing the cell S. The camera 21 constitutes the photographing unit of the microscope 20. The microscope 20 has a support 22 that positions the camera 21 on one side of the cell S in the z direction so that the camera 21 can photograph the cell S from that side. The support 22 supports the camera 21 with the camera 21 connected to the end of that side of the support 22. The microscope 20 has a holder 23 that holds a petri dish C in which the cell S is placed from the other side in the z direction. The holder 23 is configured as a stage that can move in two directions, the x direction and the y direction. The microscope 20 has a support 24 that is located at the end of the other side of the support 22 and supports the holder 23 that holds the petri dish C.

[0038] The cell puncture device 10 has a first fixing part 11 arranged relative to an imaging part that images the cell S. The first fixing part 11 is fixed to, for example, a microscope 20 that images the cell S. The first fixing part 11 is configured in an arm shape and extends in the x direction. One side of the first fixing part 11 in the x direction is screwed to the support part 24 of the microscope 20, thereby disposing the first fixing part 11 relative to the holder 23 and the support part 24 and fixing it to the microscope 20. As an example, the first fixing part 11 is located between the holder 23 and the support part 24, but this is not limiting. The holder 23 may also be located below the first fixing part 11. The first fixing part 11 is not limited to being screwed to the support part 24, and may be fixed to the microscope 20 in any other manner, such as by joining, fitting, or engagement. The cell puncture device 10 can be attached to the microscope 20 via the first fixing part 11.

[0039] The cell puncturing device 10 has a base 12 connected to the other side of the first fixing part 11 in the x direction and located on the surface of the first fixing part 11. The cell puncturing device 10 is supported by the first fixing part 11 and the base 12 and has a first driving part 13 that protrudes from the base 12 toward the positive side in the z direction. The cell puncturing device 10 has an arm 14 that extends from the first driving part 13 toward the positive side in the x direction. The arm 14 is disposed relative to the first fixing part 11. For example, the arm 14 is disposed parallel to the first fixing part 11. The first driving part 13 drives the arm 14 so that the arm 14 can move in each of the x direction, y direction, and z direction relative to the base 12.

[0040] The cell puncturing device 10 has a support unit 15 connected to the x-direction tip of the arm unit 14. The support unit 15 is for mounting a vibration suppression unit 19a and a restriction unit 19b, which will be described later. The cell puncturing device 10 has a second drive unit 16 located inside the support unit 15 so as to be sandwiched between the outer frames of the support unit 15. This is not limiting, and the second drive unit 16 does not have to be located inside the support unit 15. The second drive unit 16, together with the vibration suppression unit 19a, may be located at another location outside the support unit 15. The second drive unit 16 is arranged relative to the arm unit 14 via the restriction unit 19b and the support unit 15. The second drive unit 16 is arranged relative to the support unit 15 via the vibration suppression unit 19a.

[0041] The second driving unit 16 needs to move the needle 17a at a high speed to puncture the cell S. To achieve such high-speed movement of the needle 17a, the second driving unit 16 includes, for example, a piezoelectric element that drives the needle 17a. The second driving unit 16 includes a second fixed unit 16a connected to a restricting unit 19b (described later) and a first movable unit 16b connected to the second fixed unit 16a and driving the needle 17a. The first movable unit 16b is movable relative to the second fixed unit 16a. The piezoelectric element included in the first movable unit 16b drives the needle 17a so that the tip of the needle 17a moves along the z-direction, for example. The first movable unit 16b moves relative to the second fixed unit 16a to cause the needle 17a to puncture the cell S.

[0042] The cell puncture device 10 has a needle unit 17 that has a needle 17a at its tip that punctures the cell S and is driven by a first movable unit 16b of a second drive unit 16. The needle unit 17 is driven by the second drive unit 16 and has the needle 17a that punctures the cell S, and a needle fixing unit 17b that fixes the needle 17a.

[0043] Needle fixing portion 17b enables needle 17a to be attached to and detached from support head 18b (described later) when replacing needle 17a. Needle fixing portion 17b is detachably attached to support head 18b in any manner, such as by screwing, joining, fitting, or engagement. Needle fixing portion 17b may have, for example, a fixing screw portion connected to needle 17a, and be attached to support head 18b by threading the fixing screw portion into a threaded portion disposed on support head 18b. Needle fixing portion 17b may have, for example, an axial structure that fits support head 18b, and be attached to support head 18b by fitting with support head 18b based on the axial structure.

[0044] The cell puncture device 10 has a needle support unit 18 connected to the needle fixing unit 17b and having the needle unit 17 positioned at its tip. The needle support unit 18 has a moving unit 18a that moves the needle unit 17 between a first position when the needle 17a punctures the cell S and a second position when the needle 17a is retracted. The needle support unit 18 has a support head 18b that connects the moving unit 18a and the needle fixing unit 17b. As an example, the moving unit 18a includes a rotation mechanism to which the support head 18b that supports the needle unit 17 at its tip is connected. The moving unit 18a may non-detachably fix the support head 18b in any manner, such as by screwing, joining, fitting, or engagement, or the support head 18b may be detachably fixed.

[0045] The moving unit 18a supports the needle 17 so that it can rotate clockwise and counterclockwise around a rotation axis along the y-axis. For example, the moving unit 18a determines the position of the needle 17 shown in FIG. 1 when the needle 17a punctures the cell S as the first position. For example, the moving unit 18a determines an arbitrary position when the needle 17 rotates counterclockwise from the first position as the second position.

[0046] The cell puncture device 10 has a vibration damping unit 19a that damps the vibration of the needle 17a. The vibration damping unit 19a includes, for example, a vibration damping rubber. The vibration damping unit 19a may be disposed relative to at least one of the arm unit 14 and the second drive unit 16. For example, in FIG. 1, the vibration damping unit 19a is disposed so that the vibration damping surface 19a1 contacts only the first movable unit 16b of the second drive unit 16. A pair of vibration damping units 19a are disposed on both sides of the second drive unit 16 in the z direction. This is not a limitation, and only one vibration damping unit 19a may be disposed relative to the second drive unit 16, or three or more vibration damping units 19a may be disposed. The vibration damping unit 19a is disposed between the support unit 15 and the second drive unit 16 so as to fill the gap along the z direction between the support unit 15 and the second drive unit 16.

[0047] Vibration damping unit 19a is disposed so that vibration damping surface 19a1 intersects with the puncturing motion direction of needle 17a. In the present disclosure, the "puncturing motion direction" corresponds to, for example, the z direction. For example, vibration damping surface 19a1 is perpendicular to the z direction, which is the puncturing motion direction of needle 17a. Vibration damping surface 19a1 forms the contact surface of vibration damping unit 19a with first movable unit 16b, and contacts the surface of first movable unit 16b in the z direction. Vibration damping surface 19a1 is included in the xy plane, for example. When second drive unit 16 vibrates and presses and deforms vibration damping unit 19a, vibration damping unit 19a performs vibration damping by converting part of the vibration energy of second drive unit 16 into thermal energy.

[0048] The cell puncture device 10 has a restricting part 19b that is disposed relative to the second drive part 16 and restricts the movement direction of the second drive part 16 to the puncture operation direction of the needle 17a. The restricting part 19b includes a third fixed part 19b1 that is disposed relative to the arm part 14, and a second movable part 19b2 that is connected to the third fixed part 19b1 and the second fixed part 16a of the second drive part 16. The third fixed part 19b1 is connected to, for example, the inner surface of the support part 15 along the z direction.

[0049] Restriction unit 19b includes, for example, a linear guide and a cross roller guide. Restriction unit 19b allows movement in the puncturing operation direction in which second drive unit 16 moves to puncture needle 17a into cell S, but restricts movement of second drive unit 16 in a direction perpendicular to that direction. For example, if the puncturing operation direction is the z direction, restriction unit 19b allows movement of second drive unit 16 along the z direction, but restricts movement in the x and y directions.

[0050] The cell puncture device 10 may be configured so that the entire components, including the first drive unit 13, arm unit 14, support unit 15, second drive unit 16, and needle 17a, can be retracted from the microscope 20 by moving the pedestal unit 12 in the x or y direction or by rotating the pedestal unit 12 relative to the first fixed unit 11. Movement of the pedestal unit 12 in the x or y direction can be easily achieved, for example, by arranging a linear guide, a cross roller guide, or the like between the first fixed unit 11 and the pedestal unit 12. Rotational movement of the pedestal unit 12 can be easily achieved, for example, by arranging a ball bearing, a cross roller bearing, or the like between the first fixed unit 11 and the pedestal unit 12.

[0051] The cell puncture device 10 may further include a fixing portion (not shown) between the first fixing portion 11 and the pedestal portion 12 to prevent relative movement in the x or y direction or relative rotational movement of the pedestal portion 12 with respect to the first fixing portion 11. The fixing portion may fix the pedestal portion 12 by the frictional force of a pin that is movable in the z direction and pressed against the first fixing portion 11 by a spring, or the pedestal portion 12 may be fixed by a similar pin engaging with a groove provided in the first fixing portion 11. The pin can be easily lifted by arranging an operating portion for lifting the pin on the positive side of the z direction. The pin allows the pedestal portion 12 to be moved relative to the first fixing portion 11 and fixed.

[0052] With the above-described configuration, cell puncturing device 10 can accurately position pedestal 12 relative to first fixing part 11. Cell puncturing device 10 can reduce fluctuations in the position of needle 17a due to play in pedestal 12 relative to first fixing part 11.

[0053] FIG. 2 is a schematic diagram showing an example of the configuration of a circuit module 30 according to the first embodiment of the present disclosure. The cell puncturing device 10 further includes the circuit module 30 shown in FIG. 2. The circuit module 30 outputs a voltage to a circuit element 16b1 included in the second driving unit 16. The needle 17a of the needle unit 17 is driven by the circuit element 16b1 and punctures the cell S. The circuit element 16b1 includes, for example, a piezoelectric element. For example, the second driving unit 16 needs to move the needle 17a at a high speed to puncture the cell S, and may include a piezoelectric element as the circuit element 16b1 to achieve high-speed movement of the needle 17a.

[0054] The circuit module 30 has a first connector 31 disposed on the circuit element 16b1 side and a second connector 32 disposed on the opposite side of the first connector 31. The circuit module 30 has a cable 33 connecting the first connector 31 and the second connector 32. In FIG. 2, the first connector 31 is attached directly to the second drive unit 16 including the circuit element 16b1, as an example, but is not limited to this. The first connector 31 does not have to be attached directly to the second drive unit 16, but may be attached to any of the other components of the cell puncturing device 10 shown in FIG. 1. The second connector 32 may be attached directly to the controller 40 that controls the second drive unit 16, for example.

[0055] The controller 40 and the second drive unit 16 are electrically connected to each other via a cable 33. The controller 40 controls the second drive unit 16 by being connected to the second drive unit 16 via the cable 33. For example, the controller 40 applies a voltage to a circuit element 16b1 included in the second drive unit 16. The cell puncturing device 10 further includes a controller 40.

[0056] The controller 40 of the cell puncture device 10 is connected to a power line L1 that supplies power to the controller 40 from an external source. The power line L1 is arranged to supply power to the controller 40 at low voltages such as 5V and 24V. The controller 40 is also connected to a signal line L2 in parallel with the power line L1. The signal line L2 is arranged to transmit to the controller 40 control signals required to control the circuit element 16b1 from a control unit that is even higher level than the controller 40.

[0057] The circuit module 30 includes a first circuit breaker 34, a converter 35, a control unit 36, and a second circuit breaker 37. The first circuit breaker 34, converter 35, control unit 36, and second circuit breaker 37 are arranged in this order inside the controller 40 from the second connector 32 toward the power line L1. The first circuit breaker 34 includes, for example, a first switching element. The first switching element includes, for example, a semiconductor relay such as a photoMOS relay or a solid-state relay, a mechanical relay that switches connections using mechanical contacts, and other relays and switches. The converter 35 includes a conversion element that converts a low-voltage signal input to the circuit module 30 into a high-voltage signal that drives the circuit element 16b1. The control unit 36 ​​includes a control element that outputs a control signal input as a low-voltage signal from the signal line L2 to the converter 35. The second circuit breaker 37 includes, for example, a second switching element. The second switching element includes, for example, a semiconductor relay such as a photoMOS relay or a solid-state relay, and a relay such as a mechanical relay that switches connections by mechanical contacts, as well as a switch.

[0058] The circuit module 30 has a first confirmation unit that changes its state when the first connector 31 or the second connector 32 is disconnected from the cable 33. In the first embodiment, the first confirmation unit includes a first wiring 38a that loops between the first interrupter 34 and the first connector 31 via the second connector 32 and the cable 33. In the first embodiment, the "state" of the first confirmation unit includes, for example, the conductive state of the first wiring 38a as the first confirmation unit, i.e., the connected state of the loop.

[0059] The first wiring 38a extends from the first interrupter 34 and passes through a second connection portion P2 between the second connector 32 and the cable 33. The first wiring 38a further extends inside the cable 33 and reaches a first connection portion P1 between the first connector 31 and the cable 33. The first wiring 38a turns back inside the first connector 31 and passes through the first connection portion P1, extends inside the cable 33, and returns to the first interrupter 34 via the second connection portion P2. The first wiring 38a is not limited to a configuration in which it turns back inside the first connector 31, and may also be turned back outside the first connector 31.

[0060] The circuit module 30 has a second confirmation unit that changes its state when the first connector 31 or the second connector 32 is disconnected from the cable 33. In the first embodiment, the second confirmation unit includes a second wiring 38b that loops between the second interrupter 37 and the first connector 31 via the second connector 32 and the cable 33. In the first embodiment, the "state" of the second confirmation unit includes, for example, the conductive state of the second wiring 38b as the second confirmation unit, i.e., the connected state of the loop.

[0061] The second wiring 38b extends from the second interrupter 37 and passes through a fourth connection portion P4 between the second connector 32 and the cable 33. The second wiring 38b further extends inside the cable 33 and reaches a third connection portion P3 between the first connector 31 and the cable 33. The second wiring 38b turns back inside the first connector 31 and passes through the third connection portion P3, extends inside the cable 33, and returns to the second interrupter 37 via the fourth connection portion P4. The second wiring 38b is not limited to a configuration in which it turns back inside the first connector 31, and may also be turned back outside the first connector 31.

[0062] The first connection portion P1, the second connection portion P2, the third connection portion P3, and the fourth connection portion P4 may be, for example, connection portions each consisting of two pairs of male and female connectors forming a loop, and may be connector terminals consisting of two pairs of plugs and receptacles.

[0063] The circuit module 30 has a third wiring 38c extending from the control unit 36 ​​to the circuit element 16b1 via the conversion unit 35, the first cutoff unit 34, the second connector 32, the cable 33, and the first connector 31. The third wiring 38c is arranged to transmit a control signal from the signal line L2 from the control unit 36 ​​to the circuit element 16b1. The circuit module 30 has a fourth wiring 38d connected from the second cutoff unit 37 to both the control unit 36 ​​and the conversion unit 35.

[0064] As described above, cable 33 aggregates first wiring 38a serving as a first confirmation unit and second wiring 38b serving as a second confirmation unit, in addition to third wiring 38c serving as a control line for controlling circuit element 16b1. One end of cable 33 is connected to first connector 31, and the other end is connected to second connector 32, thereby connecting second drive unit 16 including circuit element 16b1 to controller 40.

[0065] The following mainly describes the functions of the components of the circuit module 30 when the cable 33 is connected to both the first connector 31 and the second connector 32.

[0066] The second cutoff unit 37 supplies power input from the power supply line L1 to the control unit 36 ​​and the conversion unit 35 via the fourth wiring 38d. The control unit 36 ​​outputs a control signal input as a low-voltage signal from the signal line L2 to the conversion unit 35 as a signal for operating the circuit element 16b1. At this time, the control unit 36 ​​may convert the signal format of the control signal as needed. The conversion unit 35 converts the control signal output as a low-voltage signal from the control unit 36 ​​into a high-voltage signal that drives the circuit element 16b1. The first cutoff unit 34 passes the high-voltage signal output from the conversion unit 35. The third wiring 38c transmits the high-voltage signal that has passed through the first cutoff unit 34 to the circuit element 16b1, thereby operating the circuit element 16b1.

[0067] Next, the functions of the first confirmation unit and first cut-off unit 34 and the second confirmation unit and second cut-off unit 37 will be mainly described.

[0068] The first cutoff unit 34 is connected to the conversion unit 35 via the third wiring 38c and also connected to the first wiring 38a, which serves as the first confirmation unit. The first cutoff unit 34 contributes to cutting off the voltage to the circuit element 16b1 in response to a change in the state of the first confirmation unit. For example, when the first cutoff unit 34 is disposed between the conversion unit 35 and the second connector 32, it cuts off the high-voltage signal output from the conversion unit 35. In the present disclosure, "disposed between A and B" means that the first cutoff unit 34 may be disposed at any position between A and B.

[0069] For example, when the cable 33 is connected to both the first connector 31 and the second connector 32 and the loop of the first wiring 38a serving as the first confirmation unit is in a connected state, the first cutoff unit 34 is turned on and transmits the high-voltage signal output from the conversion unit 35. On the other hand, when the cable 33 is not connected to at least one of the first connector 31 and the second connector 32 and the loop of the first wiring 38a serving as the first confirmation unit is in a disconnected state, the first cutoff unit 34 is turned off and cuts off the high-voltage signal output from the conversion unit 35. For example, when the cable 33 is not connected to the first connector 31, the loop of the first wiring 38a is cut at the first connection portion P1. For example, when the cable 33 is not connected to the second connector 32, the loop of the first wiring 38a is cut at the second connection portion P2.

[0070] The second cutoff unit 37 is connected to the power line L1, the fourth wiring 38d, and the second wiring 38b. The second cutoff unit 37 contributes to cutting off the voltage to the circuit element 16b1 in response to a change in the state of the second confirmation unit. For example, when the second cutoff unit 37 is disposed between the power line L1 from outside the circuit module 30 and the conversion unit 35, it cuts off the power supply to the conversion unit 35.

[0071] For example, when the cable 33 is connected to both the first connector 31 and the second connector 32 and the loop of the second wiring 38b serving as the second confirmation unit is in a connected state, the second cutoff unit 37 is turned on and maintains the power supply to the conversion unit 35. On the other hand, when the cable 33 is not connected to at least one of the first connector 31 and the second connector 32 and the loop of the second wiring 38b serving as the second confirmation unit is in a disconnected state, the second cutoff unit 37 is turned off and cuts off the power supply to the conversion unit 35. For example, when the cable 33 is not connected to the first connector 31, the loop of the second wiring 38b is cut at the third connection point P3. For example, when the cable 33 is not connected to the second connector 32, the loop of the second wiring 38b is cut at the fourth connection point P4.

[0072] The circuit module 30 according to the first embodiment described above improves safety when supplying voltage to the circuit element 16b1. By including the first confirmation unit and the first cutoff unit 34, the circuit module 30 can contribute to cutting off the voltage to the circuit element 16b1 at one location when the cable 33 is not connected to at least one of the first connector 31 and the second connector 32. By including the second confirmation unit and the second cutoff unit 37, the circuit module 30 can contribute to cutting off the voltage to the circuit element 16b1 at another location when the cable 33 is not connected to at least one of the first connector 31 and the second connector 32. As described above, the circuit module 30 can contribute to cutting off the voltage at multiple locations when the cable 33 is not connected, thereby more reliably suppressing voltage output.

[0073] The first confirmation unit includes a first wiring 38a that loops between the first cutoff unit 34 and the first connector 31 via the second connector 32 and the cable 33. This allows the circuit module 30 to directly cut off the voltage to the circuit element 16b1 in response to a change in the conduction state of the first wiring 38a. Therefore, the circuit module 30 can more reliably suppress voltage output when the cable 33 is in a disconnected state.

[0074] The second confirmation unit includes a second wiring 38b that loops between the second cutoff unit 37 and the first connector 31 via the second connector 32 and the cable 33. This allows the circuit module 30 to indirectly cut off the voltage to the circuit element 16b1 in response to a change in the conduction state of the second wiring 38b. Therefore, the circuit module 30 can more reliably suppress voltage output when the cable 33 is in a disconnected state.

[0075] The circuit module 30 is disposed on the second connector 32 side and has a conversion unit 35 that converts a low-voltage signal input to the circuit module 30 into a high-voltage signal that drives the circuit element 16b1. This allows the circuit module 30 to easily drive the circuit element 16b1, even when a high voltage is required to drive the circuit element 16b1, for example.

[0076] The first cutoff unit 34 is disposed between the conversion unit 35 and the second connector 32, and cuts off the high-voltage signal output from the conversion unit 35. This allows the circuit module 30 to directly cut off the voltage to the circuit element 16b1 by the first cutoff unit 34.

[0077] The second cutoff unit 37 is disposed between the power supply line L1 from outside the circuit module 30 and the conversion unit 35, and cuts off the power supply to the conversion unit 35. This allows the circuit module 30 to indirectly cut off the voltage to the circuit element 16b1 by means of the second cutoff unit 37.

[0078] Because the circuit element 16b1 of the cell puncturing device 10 includes a piezoelectric element, the needle 17a can be moved at high speed when puncturing the cell S. Therefore, the cell puncturing device 10 can easily control the position and speed of the needle tip so that the needle tip penetrates the cell wall in order to inject a chemical solution into the cell S or to suck and extract a substance inside the cell S. By combining the circuit module 30 with a piezoelectric element, the cell puncturing device 10 can improve safety even against voltages applied to the piezoelectric element, which can be as high as about 150 V, for example.

[0079] In the first embodiment, the circuit module 30 is described as being disposed on the second connector 32 side and including the conversion unit 35 that converts a low-voltage signal input to the circuit module 30 into a high-voltage signal that drives the circuit element 16b1. However, the present invention is not limited to this. The circuit module 30 does not necessarily have to include the conversion unit 35.

[0080] In the first embodiment, the first cutoff unit 34 is disposed between the conversion unit 35 and the second connector 32 and is described as cutting off the high-voltage signal output from the conversion unit 35, but this is not limiting. The first cutoff unit 34 may be disposed at another position in the circuit module 30 and cut off the circuit at that position. For example, the first cutoff unit 34 may be disposed immediately after the control unit 36 ​​and cut off the low-voltage signal output from the control unit 36.

[0081] In the first embodiment, the second cutoff unit 37 is disposed between the power line L1 from outside the circuit module 30 and the conversion unit 35, and is described as cutting off the power supply to the conversion unit 35. However, the present invention is not limited to this. The second cutoff unit 37 may be disposed at another position in the circuit module 30 and cut off the circuit at that position. As shown in FIG. 2 , the second cutoff unit 37 may be connected to the control unit 36 ​​in addition to the conversion unit 35, and cut off the power supply to the control unit 36 ​​instead of or in addition to the conversion unit 35.

[0082] In the first embodiment, the circuit element 16b1 is described as including a piezoelectric element, but is not limited to this. The circuit element 16b1 may include any other element that operates when a voltage is applied from the circuit module 30.

[0083] In the first embodiment, the circuit module 30 is described as being used in the cell puncture device 10 and the microscope system 1, but is not limited thereto. The circuit module 30 may be used in any other device having a circuit element that outputs a voltage.

[0084] In the first embodiment, the first fixing unit 11 is described as being fixed to, for example, the microscope 20 that photographs the cell S, but this is not limiting. The first fixing unit 11 may be attached to the microscope 20 in other ways as long as it is disposed relative to the photographing unit that photographs the cell S. For example, instead of being configured to be fixed so as to extend outward from the microscope 20 as described above, the first fixing unit 11 may be incorporated inside the microscope 20.

[0085] (Second embodiment) 3 is a schematic diagram showing an example of the configuration of a circuit module 30 according to a second embodiment of the present disclosure. An example of the configuration and functions of the circuit module 30 according to the second embodiment will be mainly described with reference to FIG.

[0086] In the first embodiment, the first confirmation unit is described as including the first wiring 38a that loops between the first blocking unit 34 and the first connector 31 via the second connector 32 and the cable 33, but is not limited to this. The first confirmation unit may include a plurality of communication elements, which will be described later. Similarly, in the first embodiment, the second confirmation unit is described as including the second wiring 38b that loops between the second blocking unit 37 and the first connector 31 via the second connector 32 and the cable 33, but is not limited to this. The second confirmation unit may include a plurality of communication elements, which will be described later.

[0087] The circuit module 30 according to the second embodiment differs from the first embodiment in the above respects. Other configurations, functions, effects, and modifications are the same as those of the first embodiment, and the corresponding explanations also apply to the circuit module 30 according to the second embodiment. In the following, components that are the same as those in the first embodiment are given the same reference numerals, and their explanations will be omitted. Differences from the first embodiment will be mainly explained.

[0088] 3, the first wiring 38a extends from the first blocking portion 34 and passes through the second connection portion P2 between the second connector 32 and the cable 33. The first wiring 38a further extends inside the cable 33 and reaches the first connection portion P1 between the first connector 31 and the cable 33. In the second embodiment, the first wiring 38a may be arranged with its tip cut off inside the first connector 31. The first wiring 38a may terminate inside the first connector 31 without being looped.

[0089] In the second embodiment, the first confirmation unit may include a plurality of communication elements instead of the first wiring 38a. For example, the first confirmation unit may include a first communication element that is arranged at a first connection portion P1 between the cable 33 and the first connector 31 and that detects a disconnected state between the first connector 31 and the cable 33 and outputs a first communication signal to the first cutoff unit 34. The first confirmation unit may include a second communication element that is arranged at a second connection portion P2 between the cable 33 and the second connector 32 and that detects a disconnected state between the second connector 32 and the cable 33 and outputs a second communication signal to the first cutoff unit 34. In the second embodiment, the "state" of the first confirmation unit may include, for example, each of an output state of the first communication signal from the first communication element serving as the first confirmation unit and an output state of the second communication signal from the second communication element.

[0090] The first communication element may include, for example, a communication element that enables communication via a Controller Area Network (CAN), a communication element that enables communication via Recommended Standard 232 version C (RS-232C), and a communication element that enables wireless communication via Radio Frequency Identification (RF-ID). The first communication element may output a first communication signal indicating a disconnected state when the first connector 31 and the cable 33 are not connected to each other at the first connection portion P1 to the first cutoff portion 34 via a wired connection via the first wiring 38a or wirelessly without via the first wiring 38a.

[0091] The second communication element may include, for example, a communication element that enables communication via CAN, a communication element that enables communication via RS-232C, and a communication element that enables wireless communication via RF-ID, etc. The second communication element may output a second communication signal indicating a disconnected state when the second connector 32 and the cable 33 are not connected to each other at the second connection portion P2 to the first cutoff portion 34 in a wired manner via the first wiring 38a or wirelessly without via the first wiring 38a.

[0092] The first cutoff unit 34 contributes to cutting off the voltage to the circuit element 16b1 in response to a change in the state of the first confirmation unit. For example, the first cutoff unit 34 cuts off the high-voltage signal output from the conversion unit 35 when disposed between the conversion unit 35 and the second connector 32. For example, the first cutoff unit 34 may be turned off and cut off the high-voltage signal output from the conversion unit 35 when it receives at least one of a first communication signal from the first communication element and a second communication signal from the second communication element.

[0093] 3, the second wiring 38b extends from the second blocking portion 37 and passes through a fourth connection portion P4 between the second connector 32 and the cable 33. The second wiring 38b further extends inside the cable 33 and reaches a third connection portion P3 between the first connector 31 and the cable 33. In the second embodiment, the second wiring 38b may be disposed with its tip cut off inside the first connector 31. The second wiring 38b may terminate inside the first connector 31 without being looped.

[0094] In the second embodiment, the second confirmation unit may include a plurality of communication elements instead of the second wiring 38b. For example, the second confirmation unit may include a third communication element that is arranged at a third connection portion P3 between the cable 33 and the first connector 31 and that detects a disconnected state between the first connector 31 and the cable 33 and outputs a third communication signal to the second cutoff unit 37. The second confirmation unit may include a fourth communication element that is arranged at a fourth connection portion P4 between the cable 33 and the second connector 32 and that detects a disconnected state between the second connector 32 and the cable 33 and outputs a fourth communication signal to the second cutoff unit 37. In the second embodiment, the "state" of the second confirmation unit may include, for example, each of an output state of the third communication signal from the third communication element and an output state of the fourth communication signal from the fourth communication element serving as the second confirmation unit.

[0095] The third communication element may include, for example, a communication element that enables communication via CAN, a communication element that enables communication via RS-232C, and a communication element that enables wireless communication via RF-ID, etc. The third communication element may output a third communication signal indicating a disconnected state when the first connector 31 and the cable 33 are not connected to each other at the third connection portion P3 to the second cutoff portion 37 in a wired manner via the second wiring 38b or wirelessly without via the second wiring 38b.

[0096] The fourth communication element may include, for example, a communication element that enables communication via CAN, a communication element that enables communication via RS-232C, and a communication element that enables wireless communication via RF-ID, etc. The fourth communication element may output a fourth communication signal indicating a disconnected state when the second connector 32 and the cable 33 are not connected to each other at the fourth connection portion P4 to the second cutoff portion 37 in a wired manner via the second wiring 38b or wirelessly without via the second wiring 38b.

[0097] The second cutoff unit 37 contributes to cutting off the voltage to the circuit element 16b1 in response to a change in the state of the second confirmation unit. For example, the second cutoff unit 37 cuts off the power supply to the conversion unit 35 when it is disposed between the power line L1 from outside the circuit module 30 and the conversion unit 35. For example, the second cutoff unit 37 may be turned off and cut off the power supply to the conversion unit 35 when it receives at least one of a third communication signal from a third communication element and a fourth communication signal from a fourth communication element.

[0098] The circuit module 30 according to the second embodiment described above provides the same effects as those of the first embodiment. Additionally, since the first confirmation unit of the circuit module 30 includes the first communication element and the second communication element, the circuit module 30 can directly cut off the voltage to the circuit element 16b1 in response to a change in the output state of the communication signal from each communication element. Therefore, the circuit module 30 can more reliably suppress the voltage output when the cable 33 is in a disconnected state.

[0099] In the circuit module 30, the second confirmation unit includes the third and fourth communication elements, so that the voltage to the circuit element 16b1 can be indirectly cut off in response to changes in the output state of the communication signal from each communication element. Therefore, the circuit module 30 can more reliably suppress the voltage output when the cable 33 is in a disconnected state.

[0100] It will be apparent to those skilled in the art that the present disclosure can be embodied in other specific forms other than the above-described embodiments without departing from the spirit or essential characteristics thereof. Therefore, the foregoing description is illustrative and not limiting. The scope of the disclosure is defined not by the foregoing description but by the appended claims. Any modifications within the range of equivalents of all modifications are intended to be embraced therein.

[0101] For example, the shape, pattern, size, arrangement, orientation, type, and number of each of the above-mentioned components are not limited to those shown in the above description and drawings. The shape, pattern, size, arrangement, orientation, type, and number of each component may be configured arbitrarily as long as the function can be realized. The illustrated components of the circuit module 30, cell puncture device 10, and microscope system 1 are functional concepts, and the specific form of each component is not limited to those shown.

[0102] The functions included in each of the above-mentioned components can be rearranged so as not to cause logical inconsistencies, and multiple components can be combined into one or separated.

[0103] Fig. 4 is a schematic diagram showing an example of the configuration of a circuit module 30 according to a first modified example of the present disclosure. An example of the configuration and function of the circuit module 30 according to the first modified example will be mainly described with reference to Fig. 4. In Fig. 4, differences related to the modified example are shown in correspondence with Fig. 3, which shows the circuit module 30 according to the second embodiment, but these differences also apply to the circuit module 30 according to the first embodiment.

[0104] In the first and second embodiments, the second cutoff unit 37 is disposed between the power supply line L1 from outside the circuit module 30 and the conversion unit 35, and is described as cutting off the power supply to the conversion unit 35. However, the present invention is not limited to this. As shown in FIG. 4 , the second cutoff unit 37 may be disposed between the signal line L2 from outside the circuit module 30 and the conversion unit 35, and cut off a low-voltage signal input to the conversion unit 35.

[0105] For example, when the second cutoff unit 37 receives at least one of the third communication signal from the third communication element and the fourth communication signal from the fourth communication element, it may be turned off and cut off the low-voltage signal input to the conversion unit 35. For example, the second cutoff unit 37 does not output the low-voltage signal input from the signal line L2 to the control unit 36. As a result, the low-voltage signal is not output from the control unit 36 ​​to the conversion unit 35, and therefore no high-voltage signal is generated.

[0106] 4, the second cutoff unit 37 is connected to the signal line L2 and the second wiring 38b. In addition, the second cutoff unit 37 is also connected to the third wiring 38c. In the controller 40, the second cutoff unit 37, the control unit 36, the conversion unit 35, and the first cutoff unit 34 are arranged in this order on the third wiring 38c from the signal line L2 toward the second connector 32.

[0107] The circuit module 30 according to the first modification as described above can indirectly cut off the voltage to the circuit element 16b1 by the second cutoff unit 37. The circuit module 30 also achieves the same effects as the first and second embodiments. That is, by performing doubly-blocking by the second cutoff unit 37 and the first cutoff unit 34 when the cable 33 is in a disconnected state, the circuit module 30 can more reliably suppress the output of high-voltage signals and improve safety.

[0108] Fig. 5 is a schematic diagram showing an example of the configuration of a circuit module 30 according to a second modified example of the present disclosure. An example of the configuration and function of the circuit module 30 according to the second modified example will be mainly described with reference to Fig. 5. In Fig. 5, differences related to the modified example are shown in correspondence with Fig. 3, which shows the circuit module 30 according to the second embodiment, but these differences also apply to the circuit modules 30 according to the first embodiment and the first modified example.

[0109] In the first and second embodiments, the circuit module 30 has been described as having only two circuit breakers, the first circuit breaker 34 and the second circuit breaker 37. However, this is not limiting. The circuit module 30 may have three or more circuit breakers. For example, as shown in FIG. 5 , the circuit module 30 may further include a third circuit breaker 39 that contributes to blocking voltage in response to a change in the state of the first confirmation unit. The third circuit breaker 39 may be disposed between the power line L1 from outside the circuit module 30 and the first circuit breaker 34, and may cut off the power supply to the first circuit breaker 34, thereby cutting off or canceling the cutoff of the first circuit breaker 34.

[0110] As shown by the dashed line in FIG. 5, in the controller 40, the high-voltage region R includes the conversion unit 35 and the first blocking unit 34. The high-voltage region R is, for example, a region including the periphery of the third wiring 38c to which a high voltage is applied by the conversion unit 35, and is a region in which a clearance distance and a creepage distance are ensured to prevent discharge according to the maximum voltage applied. In other words, the high-voltage region R is a region in which, if an unintended conductor enters the high-voltage region R, a high voltage may be conducted from the high-voltage third wiring 38c due to discharge. The high-voltage region R is a region in which it is preferable to protect it from the entry of an unintended conductor. The region other than the high-voltage region R surrounded by the dashed line in FIG. 5 is a low-voltage region.

[0111] The third circuit breaker 39 is disposed in a low-voltage region on the first wiring 38a. The third circuit breaker 39 is connected to the first circuit breaker 34 via the first wiring 38a. When the cable 33 is in a connected state, the third circuit breaker 39 transmits power input from the power line L1 via the second circuit breaker 37 and the fourth wiring 38d to the first circuit breaker 34, thereby supplying power. The first circuit breaker 34 receives power from the third circuit breaker 39 and outputs a high-voltage signal output from the conversion unit 35 to the circuit element 16b1 via the third wiring 38c.

[0112] Third circuit breaker 39 includes, for example, a relay element, and when there is a power supply linked to the first confirmation unit, outputs power such as +5 V to first circuit breaker 34. When first circuit breaker 34 receives the power from third circuit breaker 39, it outputs the high-voltage signal input from conversion unit 35 without blocking it. On the other hand, when there is no power supply linked to the first confirmation unit, third circuit breaker 39 does not output power such as +5 V to first circuit breaker 34. When first circuit breaker 34 does not receive the power from third circuit breaker 39, it blocks the high-voltage signal input from conversion unit 35.

[0113] The circuit module 30 according to the second modification as described above can indirectly cut off the voltage to the circuit element 16b1 by the third cutoff unit 39. Compared to the first and second embodiments, the circuit module 30 further includes the third cutoff unit 39, thereby enabling cutoff by three cutoff units when the cable 33 is in a disconnected state. The circuit module 30 can perform doubly cutoff on the low-voltage side by the second cutoff unit 37 and the third cutoff unit 39, in addition to the first cutoff unit 34 that must be selected as one usable at high voltages. Therefore, the circuit module 30 can more reliably suppress the output of high-voltage signals, improving safety.

[0114] Some embodiments of the present disclosure will be described below as examples, however, it should be noted that the embodiments of the present disclosure are not limited to these examples. [Appendix 1] A circuit module that outputs a voltage to a circuit element, a first connector disposed on the circuit element side; a second connector disposed on the opposite side of the first connector; a cable connecting the first connector and the second connector; a first confirmation unit that changes its state when the first connector or the second connector and the cable are disconnected; a second confirmation unit that changes its state when the first connector or the second connector and the cable are disconnected; a first cutoff unit that contributes to cutting off the voltage in response to the change in the state of the first confirmation unit; a second cutoff unit that contributes to cutting off the voltage in response to the change in the state of the second confirmation unit; Equipped with Circuit module. [Appendix 2] 10. The circuit module of claim 1, the first confirmation unit includes a first wiring that loops between the first interrupter and the first connector via the second connector and the cable; Circuit module. [Appendix 3] 3. The circuit module according to claim 1, the second confirmation unit includes a second wiring that loops between the second interrupter and the first connector via the second connector and the cable; Circuit module. [Appendix 4] 4. The circuit module according to claim 1, The first confirmation unit a first communication element that is disposed at a first connection portion between the cable and the first connector, and that detects the disconnected state between the first connector and the cable and outputs a first communication signal to the first cutoff portion; a second communication element that is disposed at a second connection portion between the cable and the second connector, and that detects the disconnected state between the second connector and the cable and outputs a second communication signal to the first cutoff portion; Including, Circuit module. [Appendix 5] 5. A circuit module according to any one of claims 1 to 4, The second confirmation unit a third communication element that is disposed at a third connection portion between the cable and the first connector, and that detects the disconnected state between the first connector and the cable and outputs a third communication signal to the second cutoff portion; a fourth communication element that is disposed at a fourth connection portion between the cable and the second connector, and that detects the disconnected state between the second connector and the cable and outputs a fourth communication signal to the second cutoff portion; Including, Circuit module. [Appendix 6] 6. The circuit module according to claim 1, a conversion unit disposed on the second connector side and converting a low-voltage signal input to the circuit module into a high-voltage signal that drives the circuit element; Circuit module. [Appendix 7] 7. The circuit module according to claim 6, The first cutoff unit is disposed between the conversion unit and the second connector and cuts off the high voltage signal output from the conversion unit. Circuit module. [Appendix 8] 8. The circuit module according to claim 6 or 7, the second cutoff unit is disposed between a power supply line from outside the circuit module and the conversion unit, and cuts off the power supply to the conversion unit. Circuit module. [Appendix 9] 9. The circuit module according to any one of Supplementary Notes 6 to 8, the second cutoff unit is disposed between a signal line from outside the circuit module and the conversion unit, and cuts off the low-voltage signal input to the conversion unit. Circuit module. [Appendix 10] 10. The circuit module according to any one of Supplementary Notes 1 to 9, a third cutoff unit that contributes to cutting off the voltage in response to the change in the state of the first confirmation unit; the third cutoff unit is disposed between a power supply line from outside the circuit module and the first cutoff unit, and cuts off the power supply to the first cutoff unit, thereby cutting off or canceling the cutoff of the first cutoff unit; Circuit module. [Appendix 11] A circuit module according to any one of Supplementary Notes 1 to 10; the circuit element; a needle driven by the circuit element and puncturing a cell; Equipped with Cell puncture device. [Appendix 12] 12. The cell puncture device according to claim 11, the circuit element includes a piezoelectric element; Cell puncture device. [Appendix 13] A microscope system comprising the cell puncture device described in Appendix 11 or 12. [Explanation of symbols]

[0115] 1. Microscope system 10 Cell puncture device 11 1st fixed part 12 Base 13 First drive unit 14 Arm section 15 Support part 16 Second drive unit 16a 2nd fixed part 16b 1st moving part 16b1 Circuit elements 17 Needle 17a needle 17b Needle fixing part 18 Needle support 18a Moving part 18b Support Head 19a Vibration damping section 19a1 Vibration-damping surface 19b Regulatory Department 19b1 3rd fixed part 19b2 ​​2nd moving part 20. Microscope 21 Camera 22 Posts 23 Holding part 24 Support part 30 Circuit Module 31 First Connector 32 Second Connector 33 Cable 34 First Interrupter 35 Conversion unit 36 Control Unit 37 Second Interrupter 38a First wiring (first confirmation part) 38b 2nd wiring (2nd confirmation part) 38c 3rd wiring 38d 4th wiring 39 Third Interceptor 40 Controller C Petri dish L1 power line L2 signal line P1 First connection part P2 Second connection part P3 Third connection part P4 4th connection part R High voltage area S cell

Claims

1. A circuit module that outputs a voltage to a circuit element, a first connector disposed on the circuit element side; a second connector disposed on the opposite side of the first connector; a cable connecting the first connector and the second connector; a first confirmation unit that changes its state when the first connector or the second connector and the cable are disconnected; a second confirmation unit that changes its state when the first connector or the second connector and the cable are disconnected; a first cutoff unit that contributes to cutting off the voltage in response to the change in the state of the first confirmation unit; a second cutoff unit that contributes to cutting off the voltage in response to the change in the state of the second confirmation unit; Equipped with Circuit module.

2. 2. The circuit module according to claim 1, the first confirmation unit includes a first wiring that loops between the first interrupter and the first connector via the second connector and the cable; Circuit module.

3. 3. The circuit module according to claim 1, the second confirmation unit includes a second wiring that loops between the second interrupter and the first connector via the second connector and the cable; Circuit module.

4. 3. The circuit module according to claim 1, The first confirmation unit a first communication element disposed at a first connection portion between the cable and the first connector, the first communication element detecting the disconnected state between the first connector and the cable and outputting a first communication signal to the first cutoff portion; a second communication element that is disposed at a second connection portion between the cable and the second connector, and that detects the disconnected state between the second connector and the cable and outputs a second communication signal to the first cutoff portion; Including, Circuit module.

5. 3. The circuit module according to claim 1, The second confirmation unit a third communication element disposed at a third connection portion between the cable and the first connector, the third communication element detecting the disconnected state between the first connector and the cable and outputting a third communication signal to the second cutoff portion; a fourth communication element disposed at a fourth connection portion between the cable and the second connector, the fourth communication element detecting the disconnected state between the second connector and the cable and outputting a fourth communication signal to the second cutoff portion; Including, Circuit module.

6. 3. The circuit module according to claim 1, a converter arranged on the second connector side and converting a low-voltage signal input to the circuit module into a high-voltage signal that drives the circuit element; Circuit module.

7. 7. The circuit module according to claim 6, The first cutoff unit is disposed between the conversion unit and the second connector and cuts off the high voltage signal output from the conversion unit. Circuit module.

8. 7. The circuit module according to claim 6, the second cutoff unit is disposed between a power supply line from outside the circuit module and the conversion unit, and cuts off the power supply to the conversion unit. Circuit module.

9. 7. The circuit module according to claim 6, the second cutoff unit is disposed between a signal line from outside the circuit module and the conversion unit, and cuts off the low-voltage signal input to the conversion unit. Circuit module.

10. 3. The circuit module according to claim 1, a third cutoff unit that contributes to cutting off the voltage in response to the change in the state of the first confirmation unit; the third cutoff unit is disposed between a power supply line from outside the circuit module and the first cutoff unit, and cuts off the power supply to the first cutoff unit, thereby cutting off or canceling the cutoff of the first cutoff unit; Circuit module.

11. The circuit module according to claim 1 or 2; the circuit element; a needle driven by the circuit element and puncturing a cell; Equipped with Cell puncture device.

12. The cell puncture device according to claim 11, the circuit element includes a piezoelectric element; Cell puncture device.

13. A microscope system comprising the cell puncture device according to claim 11.

Images