Liquid storage container, liquid-filled container, and method for dispensing a predetermined amount of liquid

Abstract

To provide a liquid storage container, liquid-filled container and method for producing a prescribed amount of a medicinal solution.SOLUTION: A liquid storage container 10 comprises: a container body 110 including a hollow body part 120 including an opening formed in a first portion 10a, and a closing part 30 provided in a second portion 10b of the body part and including a recess 31 recessed toward the body part; and a protective cover 70 for covering the recess of the closing part. When a length of a shortest straight line among straight lines connecting opening edges that define the recess when viewed from the depth direction of the recess, the straight lines passing through a center of gravity of a plane figure in which the opening edges form the outer edge when viewed from the depth direction of the recess, the length is a width W of the recess and a depth of the recess at a center point of the straight line is D, a ratio of D to W is greater than 0 and equal to or less than 0.1.SELECTED DRAWING: Figure 3

Description

[Technical Field]

[0001] The present disclosure relates to a liquid storage container, a liquid-filled container, and a method for producing a predetermined amount of a liquid medicine. [Background technology]

[0002] Containers for transporting or storing liquid medicines have been known for some time (for example, Patent Documents 1 and 2). Patent Document 1 discloses a container in which a needle piercing member made of a thermoplastic synthetic resin elastomer is fixed to at least a portion of the outer surface of a container body made of blow-molded soft synthetic resin. According to Patent Document 1, the needle piercing member made of a thermoplastic synthetic resin elastomer does not come into direct contact with the medicine inside the container, making it difficult for dust or foreign matter to enter the container, making it hygienic, and reducing manufacturing costs.

[0003] Furthermore, Patent Document 2 discloses an injection storage container that includes a container body having an injection needle insertion surface on one side and an opening on the other side, the insertion surface being thinner than the surrounding portion so that the injection needle can penetrate, and the opening on the other side being sealable. Patent Document 2 has the effect of providing an injection storage container that does not require removing the cap from the opening of the container body before drawing up the injection, and that does not require destroying the container body to form an injection needle insertion port. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2014-5056 [Patent Document 2] Japanese Patent Application Laid-Open No. 2016-16121 Summary of the Invention [Problem to be solved by the invention]

[0005] Here, for example, when extracting a liquid such as a medicinal solution from a liquid storage container such as a medical container using an injection needle, if the insertion surface into which the injection needle is inserted is not hygienic, the injection needle coming into contact with the insertion surface may degrade the hygienic quality of the liquid. Therefore, in order to maintain the hygienic quality of the liquid to be extracted, it is necessary to ensure the hygienic quality of the insertion surface into which the injection needle is inserted. For this reason, there is a need for a liquid storage container whose hygienic quality can be visually determined at the insertion surface into which the injection needle is inserted.

[0006] The present disclosure has been made in consideration of these points, and provides a liquid storage container, a container filled with liquid, and a method for manufacturing a predetermined amount of medicinal liquid, which allows the hygiene of the liquid storage container to be visually determined when removing the liquid stored in the liquid storage container. [Means for solving the problem]

[0007] The liquid storage container according to this embodiment is a liquid storage container comprising a container body having a hollow body with an opening formed in a first portion, and a closure provided in a second portion of the body with a recess formed therein that recesses toward the body, and a protective cover that covers the recess in the closure, wherein the width W of the recess is the length of the shortest straight line connecting the opening edges that define the recess when viewed from the depth direction of the recess, and passing through the center of gravity of the planar figure whose outer edge is the opening edge when viewed from the depth direction of the recess, and the depth of the recess at the center point of the straight line is D, the ratio of D to W is greater than 0 and not more than 0.1.

[0008] The liquid storage container according to this embodiment is a liquid storage container comprising a container body having a hollow body with an opening formed in a first portion, a closing portion provided in a second portion of the body and having a recess formed therein that recesses toward the body, and a protective cover that covers the recess in the closing portion, wherein a step portion is formed on the side of the recess, and the depth of the step portion is shallower than the depth of other portions of the recess, and the depth of the step portion is 1.2 mm or less.

[0009] In the liquid storage container according to this embodiment, the closing portion may be formed integrally with the body portion.

[0010] In the liquid storage container according to this embodiment, the depth of the recess may be such that, when viewed from the depth direction of the recess, the opening edge defining the recess gradually becomes deeper as it approaches the center of gravity of the planar figure constituting the outer edge, or may include a portion that becomes deeper in stages as it approaches the center of gravity.

[0011] In the liquid storage container according to this embodiment, the center of gravity of the planar figure whose outer edge is formed by the opening edge that defines the recess when viewed from the depth direction of the recess may be located at a position that does not overlap with the center of gravity of the planar figure whose outer edge is formed by the contour of the closing portion when viewed from the depth direction of the recess.

[0012] In the liquid storage container according to this embodiment, the protective cover is provided with a flange portion that extends to a position that does not overlap with the closing portion when viewed from the depth direction of the recess, and at least a portion of the flange portion may be located on a straight line connecting the center of gravity of a planar figure whose outer edge is formed by the opening edge that defines the recess when viewed from the depth direction of the recess, and the center of gravity of a planar figure whose outer edge is formed by the contour of the closing portion when viewed from the depth direction of the recess.

[0013] In the liquid storage container according to this embodiment, the recess may be provided with a mark that indicates the position of an area where the thickness of the closing portion is equal to or less than a predetermined thickness.

[0014] In the liquid storage container according to this embodiment, the width of the inner surface of the body portion may gradually narrow as it approaches the closing portion.

[0015] In the liquid storage container according to this embodiment, the body includes a first body located on the first portion side and a second body located on the second portion side of the first body, the width of the inner surface of the second body gradually narrows as it approaches the closure from the first body, and in a cross section in a plane including the central axis of the container body, when a first imaginary line is drawn that passes through an intersection point between the inner surfaces of the first body and the second body and intersects with the inner surface of the closure, but does not intersect with the inner surface of the second body, and has the shortest length from the intersection point to the inner surface of the closure, the angle formed by the first imaginary line and the inner surface of the first body may be 168° or more and less than 180°, and in the cross section, the first imaginary line may intersect with a bottom surface of the recess, and the length of the first imaginary line from the intersection point to the bottom surface of the recess may be 32.10 mm or less.

[0016] In the liquid storage container according to this embodiment, when a second imaginary line is drawn in the cross section, passing through a point 3.88 mm away from the intersection point toward the first part and forming an angle of 162° with the inner surface of the first body, the second imaginary line may intersect with the opening edge of the recess.

[0017] The liquid storage container according to this embodiment may further include a bag attached to the body of the container body and closing the opening, and a communication member attached to the bag and connecting the inside and outside of the bag.

[0018] The liquid container according to this embodiment includes the liquid storage container according to this embodiment and liquid stored in the liquid storage container, and the opening is sealed.

[0019] In the liquid-filled container of this embodiment, the container body with the opening sealed has a cylindrical portion, a sealing portion formed in the first portion, a connecting portion formed continuously between the cylindrical portion and the sealing portion, and the closing portion provided in the second portion, and the width of the connecting portion gradually increases as it approaches the sealing portion from the cylindrical portion, and when a third imaginary line is drawn in a cross section in a plane including the central axis of the container body, which third imaginary line intersects with the bottom surface of the recess and the inner edge of the sealing portion, but does not intersect with either the inner surface of the cylindrical portion or the inner surface of the connecting portion, the length of the third imaginary line from the bottom surface of the recess to the inner edge of the sealing portion may be 38 mm or less.

[0020] The liquid container according to this embodiment includes the liquid storage container according to this embodiment and the liquid stored in the bag, and the communication member is sealed.

[0021] A method for producing a predetermined amount of medicinal liquid according to this embodiment includes the steps of preparing a liquid-filled container according to this embodiment, forming an opening in the container body that communicates with the interior, and removing the liquid in the container body through the opening.

[0022] In the method for producing a predetermined amount of medicinal liquid according to this embodiment, the opening may be formed by a syringe needle, and the liquid in the container body may be extracted from the opening by the syringe needle. [Effects of the Invention]

[0023] According to this embodiment, when removing the liquid contained in the liquid container, the hygienic state of the liquid container can be visually determined. [Brief explanation of the drawings]

[0024] [Figure 1] FIG. 1 is a perspective view showing a liquid storage container according to an embodiment. [Figure 2] FIG. 2 is a bottom view (view taken in the direction of the arrow II in FIG. 1) showing a liquid storage container according to one embodiment. [Figure 3] FIG. 3 is a cross-sectional view (cross-sectional view taken along line III-III in FIG. 2) showing a liquid storage container according to one embodiment. [Figure 4] FIG. 4 is a partial enlarged view showing a recess of a liquid storage container according to one embodiment. [Figure 5] FIG. 5 is a cross-sectional view showing a protective cover for a liquid storage container according to one embodiment. [Figure 6] FIG. 6 is a perspective view showing a liquid-filled container according to one embodiment. [Figure 7] FIG. 7 is a front view showing a liquid-filled container according to one embodiment. [Figure 8] FIG. 8 is a front view showing a liquid-filled container according to one embodiment. [Figure 9] FIG. 9 is a diagram illustrating the operation of the liquid-filled container according to one embodiment. [Figure 10] FIG. 10 is a diagram illustrating the operation of the liquid container according to one embodiment. [Figure 11] FIG. 11 is a cross-sectional view showing a liquid storage container according to a first modified example. [Figure 12] FIG. 12 is a cross-sectional view showing a liquid storage container according to a second modified example. [Figure 13] FIG. 13 is a cross-sectional view showing a liquid container according to a third modified example. [Figure 14] FIG. 14 is a cross-sectional view showing a liquid storage container according to a fourth modified example. [Figure 15] FIG. 15 is a cross-sectional view showing a liquid storage container according to a fifth modified example. [Figure 16] FIG. 16 is a cross-sectional view showing a liquid storage container according to a sixth modified example. [Figure 17] FIG. 17 is a bottom view showing a liquid storage container according to a seventh modified example. [Figure 18] FIG. 18 is a cross-sectional view (cross-sectional view taken along line XVIII-XVIII in FIG. 17) showing a liquid storage container according to a seventh modified example. [Figure 19] FIG. 19 is a cross-sectional view showing a liquid storage container according to an eighth modified example. [Figure 20] FIG. 20 is a bottom view showing a liquid storage container according to an eighth modified example. [Figure 21] FIG. 21 is a bottom view showing another example of a liquid storage container according to the eighth modified example. [Figure 22] FIG. 22 is a cross-sectional view showing a liquid storage container according to a ninth modified example. [Figure 23] FIG. 23 is a cross-sectional view showing a liquid storage container according to a tenth modified example. [Figure 24] FIG. 24 is a plan view showing a liquid storage container according to an eleventh modified example. [Figure 25] FIG. 25 is a plan view showing a liquid container having a liquid storage container according to an eleventh modification. [Figure 26] FIG. 26 is a plan view showing a liquid storage container according to a twelfth modified example. [Figure 27] FIG. 27 is a plan view showing a liquid container having a liquid storage container according to a twelfth modified example. [Figure 28] FIG. 28 is a cross-sectional view showing a liquid storage container according to a thirteenth modified example. [Figure 29] FIG. 29 is a diagram illustrating a regular bevel injection needle. [Figure 30] FIG. 30 is a diagram illustrating a short-bevel injection needle. [Figure 31] FIG. 31 is a cross-sectional view illustrating the operation of the liquid storage container according to the thirteenth modified example. [Figure 32] FIG. 32 is a cross-sectional view illustrating the operation of the liquid storage container according to the thirteenth modified example. [Figure 33] FIG. 33 is a cross-sectional view illustrating the operation of the liquid storage container according to the thirteenth modified example. [Figure 34] FIG. 34 is a cross-sectional view showing a liquid storage container according to a fourteenth modified example. [Figure 35] FIG. 35 is a cross-sectional view showing a liquid storage container according to a fifteenth modified example. [Figure 36] FIG. 36 is a cross-sectional view showing a liquid storage container according to a sixteenth modified example. [Figure 37] FIG. 37 is a cross-sectional view showing a liquid storage container according to a seventeenth modified example. [Figure 38] FIG. 38 is a cross-sectional view showing a liquid container according to an eighteenth modification. [Figure 39] FIG. 39 is a cross-sectional view showing another example of a liquid container according to the nineteenth modified example. [Figure 40] FIG. 40 is a cross-sectional view showing a liquid container according to a twentieth modification. [Figure 41] FIG. 41 is a perspective view showing a liquid container according to a twenty-first modified example. [Figure 42] FIG. 42 is a cross-sectional view showing a liquid container according to a twenty-first modified example. [Figure 43] FIG. 43 is a cross-sectional view showing a liquid container according to a twenty-first modified example. [Figure 44] FIG. 44 is a cross-sectional view showing a liquid-filled container according to the twenty-first modified example in an opened state. DETAILED DESCRIPTION OF THE INVENTION

[0025] An embodiment will be described in detail below with reference to the drawings. The figures shown below are schematic illustrations. Therefore, the size and shape of each part are appropriately exaggerated for ease of understanding. Furthermore, appropriate modifications can be made within the scope of the technical concept. In the figures shown below, identical parts are denoted by the same reference numerals, and some detailed descriptions may be omitted. Furthermore, the numerical values, such as dimensions, and material names of each component described in this specification are merely examples of an embodiment and are not limited thereto. They may be selected and used as appropriate. In this specification, terms specifying shapes or geometric conditions, such as parallel, orthogonal, and vertical, are intended to include not only their strict meanings but also substantially the same state. For convenience of explanation, the terms "upper" and "lower" may be used, but the up-down direction may be reversed.

[0026] In this specification, when a certain component, region, or other structure is said to be "on (or under)" another component, region, or other structure, unless otherwise specified, this includes not only the case where it is directly above (or directly below) the other structure, but also the case where it is above (or below) the other structure, i.e., the case where another component is included between the other structure and above (or below) the other structure.

[0027] [Liquid storage container] First, the configuration of a liquid storage container according to the present embodiment will be described with reference to Figures 1 to 5. Figure 1 is a perspective view showing a liquid storage container 10 according to the present embodiment, Figure 2 is a bottom view showing the liquid storage container 10 according to the present embodiment, and Figure 3 is a cross-sectional view showing the liquid storage container 10 according to the present embodiment. Figure 4 is a partially enlarged view showing a recess of a liquid storage container according to one embodiment. Figure 5 is a cross-sectional view showing a protective cover 70 of the liquid storage container 10 according to the present embodiment.

[0028] As shown in FIGS. 1 to 3 , the liquid storage container 10 includes a container body 110 having a hollow body 120 with an opening 120a formed in a first portion 10a, a closure portion 30 provided in a second portion 10b of the body 120 and having a recess 31 recessed toward the body 120, and a protective cover 70 covering the recess 31 of the closure portion 30. In this embodiment, the first portion 10a is one end (positive end in the Z direction) of the body 120, and the opening 120a is formed at one end (positive end in the Z direction) of the body 120. The second portion 10b is the other end (negative end in the Z direction) of the body 120, and the closure portion 30 is provided at the other end (negative end in the Z direction) of the body 120. Note that the first portion 10a does not have to be at one end (positive end in the Z direction) of the body 120, and the first portion 10a may be provided at any position on the body 120. Furthermore, the second portion 10b does not have to be at the other end of the body portion 120 (the end on the negative side in the Z direction), and the second portion 10b may be provided at any position on the body portion 120 as long as it is a part different from the first portion 10a.

[0029] The container body 110 contains a liquid. The container body 110 has a central axis CL extending in the vertical direction (Z direction). The body 120 of the container body 110 has a substantially cylindrical shape, and its horizontal cross section (a plane parallel to the XY plane) is substantially circular. The horizontal cross section of the body 120 is also substantially uniform along the vertical direction (Z direction). The horizontal cross section of the body 120 is not limited to a circle, but may be a polygon such as a rectangle or hexagon, or an ellipse. The central axis CL is a straight line extending in the Z direction and is a line passing through the center of gravity of a planar figure whose outer edge is made up of the closure portion 30 when viewed from the Z direction.

[0030] The other end of the body 120 of the container body 110 is closed by a closure portion 30. The closure portion 30 forms the bottom of the liquid storage container 10 and is made of a plate-like member. When viewed from the depth direction (Z direction) of the recess 31, the planar shape of the contour of the closure portion 30 that forms the outer edge has a substantially circular shape (see FIG. 2). That is, the closure portion 30 has a substantially circular shape when viewed from the bottom. However, the shape is not limited to this, and the closing portion 30 may be a polygon such as a square or a hexagon when viewed from the bottom, or a circle, etc. The closing portion 30 is positioned parallel to the XY plane.

[0031] The closure portion 30 also has a recess 31 recessed toward the body portion 120 (see FIG. 3). In this embodiment, the recess 31 is recessed from the outer surface 30a of the closure portion 30 toward the opening 120a formed in the body portion 120. The recess 31 formed in the closure portion 30 prevents a seal layer 72 (see FIG. 5) of a protective cover 70 attached to the closure portion 30 from coming into contact with an insertion surface 33 (see FIG. 5). This prevents foreign matter from the seal layer 72 of the protective cover 70 from adhering to the insertion surface 33. The recess 31 formed in the closure portion 30 also reduces the thickness of the region where the insertion surface 33 is located. This makes it easier for the injection needle 45 to penetrate the closure portion 30 when aspirating a liquid Lq (see FIG. 8), which is the content, with the injection needle 45, as described below. The thickness T1 (see FIG. 4) of the region where the insertion surface 33 is located is preferably 0.5 mm or less, and more preferably 0.3 mm or less. By setting the thickness T1 of the region where the insertion surface 33 is located to 0.5 mm or less, it is possible to prevent the injection needle from scraping off part of the closure part 30 when the injection needle is inserted into the closure part 30, which is known as coring. The outer surface 30a of the closure part 30 is a flat surface extending in the XY plane.

[0032] Such a recess 31 includes side surfaces 32 and an injection needle insertion surface (hereinafter simply referred to as the insertion surface) 33 extending between the side surfaces 32. In this embodiment, in a cross section taken along the central axis CL of the container body 110, the side surfaces 32 are parallel to the central axis CL of the container body 110. On the other hand, the insertion surface 33 is perpendicular to the central axis CL.

[0033] In this embodiment, when the length of the shortest straight line L1 among the straight lines connecting the opening edges 31a (see FIG. 2) that define the recess 31 when viewed from the depth direction (Z direction) of the recess 31 and passing through the center of gravity G1 (hereinafter simply referred to as center of gravity G1) of the plane figure in which the opening edges 31a form the outer edge when viewed from the depth direction of the recess 31 is defined as the width W1 (W) of the recess 31, and the depth of the recess 31 at the center point CP of the straight line L1 is defined as D (the vertical distance from the outer surface 30a of the closure portion 30 to the insertion surface 33 of the recess 31; see FIG. 4; hereinafter simply referred to as depth D), the ratio of D to W1 (D / W1) is greater than 0 and not more than 0.1. In this embodiment, as shown in FIG. 2, the recess 31 is formed so that the center of gravity G1 and the center point CP of the straight line L1 each overlap the central axis CL of the container body 110 when viewed from the depth direction (Z direction) of the recess 31. However, this is not limited to this, and the recess 31 may be formed so that the center of gravity G1, the center point CP of the straight line L1, and the central axis CL of the container body 110 do not overlap with each other when viewed from the depth direction (Z direction) of the recess 31.

[0034] Incidentally, since the ratio of the depth D to the width W1 (D / W1) is greater than 0 and equal to or less than 0.1, when the liquid-filled container 40 is immersed in liquid nitrogen Ln to reduce the pressure inside the recess 31, as described below, the protective cover 70 is likely to deform so as to be recessed toward the insertion surface 33 of the recess 31, as shown in FIG. 4 (see the imaginary line (two-dot chain line) in FIG. 4). In this case, for example, even if the protective cover 70 has a leak portion 73 (described later) that connects the inside and outside of the recess 31, the protective cover 70 is likely to deform so as to be recessed toward the insertion surface 33 of the recess 31. Therefore, when the protective cover 70 has a leak portion 73 (described later), the liquid nitrogen Ln that has entered the recess 31 from the leak portion 73 can be brought into contact with the insertion surface 33 while being pressed toward the insertion surface 33 by the deformed protective cover 70. This allows the liquid nitrogen Ln that has entered the recess 31 to be caused to boil, and the protective cover 70 to be frozen in a deformed state so as to protrude from the recess 31. Therefore, when removing the liquid Lq contained in the liquid storage container 10, the hygienic state of the liquid storage container 10 can be visually determined.

[0035] Here, the protective cover 70 attached to the closure portion 30 may bend so as to be recessed toward the insertion surface 33. In this case, the protective cover 70 may bend most at the center point CP. For this reason, to prevent the protective cover 70 from coming into contact with the insertion surface 33, it is preferable that the ratio of the depth D to the width W1 (D / W1) be large. On the other hand, if the ratio of the depth D to the width W1 (D / W1) is too large, it becomes difficult for the deformed protective cover 70 to press the liquid nitrogen Ln toward the insertion surface 33 when a leak portion 73 (described later) is formed in the protective cover 70. In contrast, in this embodiment, the ratio of the depth D to the width W1 (D / W1) is 0.1 or less. Therefore, the hygienic condition of the liquid storage container 10 can be visually determined when removing the liquid Lq stored in the liquid storage container 10. The ability to visually determine the hygienic condition of the liquid storage container 10 will be described later with reference to an example.

[0036] Such recess 31 may have a substantially constant depth throughout its entire area. That is, the depth of recess 31 may be equal to the depth D of recess 31 at center point CP throughout its entire area. This depth D may be 0.1 mm or more and 4.5 mm or less. Furthermore, the width W1 of recess 31 (see FIGS. 2 and 4) may be 1 mm or more and 45 mm or less, preferably 1 mm or more and 11.5 mm or less, more preferably 1 mm or more and 7.2 mm or less, even more preferably 1 mm or more and 5 mm or less, and even more preferably 1 mm or more and 4 mm or less.

[0037] When viewed from the depth direction of the recess 31, the planar shape of the opening edge 31a that forms the outer edge has a substantially elliptical shape (see FIG. 2). That is, the recess 31 has a substantially elliptical shape when viewed from the bottom. However, the shape of the recess 31 is not limited to this, and it may be a polygon such as a square or a hexagon, or a circle when viewed from the bottom.

[0038] The closure 30 is integrally formed with the body 120. That is, the container body 110 is formed by integral molding. In this case, as described below, the possibility of the container body 110 being damaged when the liquid storage container 10 is frozen can be reduced. That is, when the container body 110 is formed by integral molding, joints between the components that may be formed when the container body 110 is composed of multiple components are not formed. Therefore, by forming the container body 110 by integral molding, it is possible to prevent the container body 110 from being damaged by the joints described above. Furthermore, by forming the container body 110 by integral molding, it is possible to increase the drop strength of the container body 110 compared to when the container body 110 is composed of multiple components. This also reduces the possibility of the container body 110 being damaged when dropped.

[0039] The material constituting the container body 110 may be any material that can be sealed. Furthermore, the material constituting the container body 110 is preferably a material that does not affect the liquid when it comes into contact with the liquid, and is appropriately selected depending on the type of liquid contained in the liquid storage container 10. Furthermore, the material constituting the container body 110 desirably has physical properties that allow it to physically withstand an environment of at least 0°C or lower, preferably −80°C or lower, more preferably −150°C or lower (i.e., the temperature inside an ultra-low temperature freezer or the temperature in the gas phase of a freezing device 100 filled with liquid nitrogen, as described below), and particularly preferably −196°C (i.e., the temperature of liquid nitrogen). Furthermore, the material constituting the container body 110 is appropriately selected depending on the application of the liquid storage container 10. Specifically, when specific properties such as strength, flexibility, water vapor permeability, heat resistance, and light transmittance are to be imparted to the liquid storage container 10, it is preferable to appropriately select a material having such properties. Such materials include thermoplastic resins, in particular polyethylenes (PE) such as low-density polyethylene, linear low-density polyethylene, medium-density polyethylene, high-density polyethylene, and ultra-high molecular weight polyethylene, polyesters such as polypropylene (PP), polyethylene terephthalate (PET), and polyethylene naphthalate (PEN), polycarbonate (PC), nylon, polystyrene, polyimide, ethylene-vinyl acetate copolymer, fluororesin, and mixtures of any combinations of these.

[0040] The container body 110 preferably has a predetermined liquid-repellent property with respect to the liquid. Therefore, the liquid-repellent property of the inner surface of the container body 110 is preferably adjusted appropriately depending on the type of liquid contained in the liquid storage container 10. Specifically, the contact angle of the inner surface of the container body 110 with respect to the liquid may be, for example, 20° or more, preferably 40° or more, more preferably 70° or more, and particularly preferably 80° or more. The contact angle of the inner surface of the container body 110 with respect to the liquid may be the contact angle with respect to water unless there are special circumstances. The contact angle can be measured according to the θ / 2 method, in which the inner surface of the container body 110 is exposed, a 1.0 μl droplet of liquid or pure water is dropped onto the exposed inner surface, and 10 seconds after the droplet lands, the contact angle is calculated from the angle of a line connecting the left and right endpoints of the dropped droplet to the vertex relative to the solid surface. For example, a contact angle meter DM 500 manufactured by Kyowa Interface Science Co., Ltd. can be used as the measuring device.

[0041] The method for imparting predetermined liquid repellency to the container body 110 is not particularly limited and can be appropriately selected depending on the material constituting the container body 110. For example, the liquid repellency may be imparted by irradiating the container body 110 with energy rays, or a material that imparts liquid repellency may be added to the material constituting the container body 110, or the inner surface of the container body 110 may be surface coated with a material that imparts liquid repellency. Examples of the energy rays include light rays such as far ultraviolet rays, ultraviolet rays, near ultraviolet rays, and infrared rays, electromagnetic waves such as X-rays and gamma rays, as well as electron beams, proton beams, and neutron beams. Among these, gamma rays are preferred.

[0042] The characteristics of the container body 110, such as thickness, strength, light transmittance, heat resistance, and gas barrier properties, can be adjusted appropriately depending on the use of the liquid storage container 10 and the type of liquid stored in the container, so they will not be described here.

[0043] The container body 110 may have a single-layer structure or a multi-layer structure. When the container body 110 has a multi-layer structure, only the inner surface of the container body 110 may be made of the resin material described above, and the other layers may have aluminum layers containing aluminum. Furthermore, the outer surface of the container body 110 may be surface-coated with a material such as silica, as necessary. In this case, the liquid storage container 10 can be provided with barrier properties.

[0044] Next, the protective cover 70 will be described. The protective cover 70 is attached to the closure portion 30. By attaching the protective cover 70 to the closure portion 30 in this manner, the insertion surface 33 can be kept hygienic before the initial opening. Furthermore, by checking whether the protective cover 70 has been removed from the closure portion 30, it is possible to easily determine whether the insertion surface 33 is being kept hygienic. In this embodiment, the protective cover 70 covers the entire closure portion 30.

[0045] This protective cover 70 may be a so-called film with a sealing layer, which is provided with a sealing layer. Since the protective cover 70 is a general film with a sealing layer, the protective cover 70 is easily available. Furthermore, the protective cover 70 can be easily attached to the container body 110 by a general processing method (for example, heat sealing).

[0046] Specifically, as shown in Fig. 5, the protective cover 70 preferably has a base material layer 71 and a seal layer 72. Of these, the base material layer 71 may be made of a resin mainly made of polyethylene terephthalate (PET), nylon, polyethylene, polypropylene, or the like, or a sheet containing aluminum or Tyvek (registered trademark).

[0047] It is preferable to use a resin material such as a coating material that can exhibit so-called easy-peel properties as the material for the sealing layer 72. By allowing the sealing layer 72 to exhibit easy-peel properties, it becomes possible to easily peel off the protective cover 70 when removing the liquid from the container body 11. Furthermore, each of the above layers is formed according to a conventional method, such as dry lamination, extrusion lamination, extrusion coating, or other coating methods such as comma reverse coating, air knife coating, comma direct coating, kiss coating, and gravure coating.

[0048] Such a liquid storage container 10 can be arranged so that the opening 120a of the container body 110 faces vertically upward and the closing portion 30 faces vertically downward. After filling the container body 110 of such a liquid storage container 10 with liquid, the end where the opening 120a is formed is heat-sealed (i.e., forming the sealing portion 20 described below), thereby forming a liquid-filled container 40 described below.

[0049] The liquid contained in the liquid storage container 10 according to the present embodiment is not particularly limited, and may be, for example, a medicinal liquid such as a pharmaceutical. Specific examples of such medicinal liquids include antirheumatic drugs, insulin preparations, sugar solutions such as glucose, electrolyte correction solutions such as sodium chloride and potassium lactate, protein preparations, antibody drugs, contrast agents, protease inhibitors, fat emulsions, antibiotics, anticancer drugs, heparin calcium anesthetics, and peritoneal dialysis solutions. Also included are so-called premixed preparations prepared by dissolving preparations such as analgesics, antipyretics, antiemetics, antitussives, antihistamines, antiallergic drugs, bronchodilators, steroids, antiarrhythmic drugs, and antiepileptic drugs in sterile water such as RO water or distilled water, or in physiological saline. Furthermore, the substance may be a biological medicine such as a vaccine for influenza, tetanus, pneumococcus, polio, Japanese encephalitis, rubella, measles, yellow fever, Hib, hepatitis, chickenpox, rabies, rotavirus, mumps, cervical cancer, MQ, DT, DPT, etc. Furthermore, the substance may be a living cell such as a bone marrow or lymphocyte. The pharmaceutical solution may also be, for example, a cell preparation, specifically, hepatoma cells, hepatocytes (liver parenchymal cells), Kupffer cells, endothelial cells such as vascular endothelial cells and corneal endothelial cells, fibroblasts, osteoblasts, osteoclasts, periodontal ligament-derived cells, epidermal cells such as epidermal keratinocytes, epithelial cells such as tracheal epithelial cells, gastrointestinal epithelial cells, cervical epithelial cells, and corneal epithelial cells, mammary gland cells, pericytes, muscle cells such as smooth muscle cells and cardiac muscle cells, kidney cells, pancreatic islet cells of Langerhans, nerve cells such as peripheral nerve cells and optic nerve cells, chondrocytes, bone cells, or stem cells, embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells), etc. Examples of stem cells include bone marrow undifferentiated mesenchymal stem cells, hematopoietic stem cells, vascular stem cells, neural stem cells, small intestinal stem cells, adipose stem cells, skin stem cells, periodontal tissue stem cells, ciliary body stem cells, corneal limbal stem cells, and visceral stem cells.

[0050] Alternatively, the liquid contained in the liquid container 10 may be a food-related liquid, specifically a liquid such as a beverage or seasoning.

[0051] The liquid container 10 according to this embodiment can be used, for example, as a medical container or a food container for storing the liquid as described above.

[0052] [Liquid container] Next, the configuration of a liquid-filled container 40 according to this embodiment will be described with reference to Figures 6 to 8. Figure 6 is a perspective view showing a liquid-filled container 40 according to this embodiment, and Figures 7 and 8 are front views showing a liquid-filled container 40 according to this embodiment. Such a liquid-filled container 40 is formed by filling the container body 110 of the liquid storage container 10 with liquid, and then heat-sealing the open end of the container body 110 where the opening 120a is formed.

[0053] 6 and 7, a liquid-filled container 40 includes the above-described liquid storage container 10 and liquid Lq stored in the liquid storage container 10. In the liquid-filled container 40, the opening 120a of the container body 110 of the liquid storage container 10 is sealed. First, the container body 110 with the sealed opening 120a will be described. In this specification, the container body 110 with the sealed opening 120a will also be simply referred to as the container body 11.

[0054] The container body 11 has a cylindrical body 12, a sealing portion 20 formed at one end, a connecting portion 13 formed continuously between the body 12 and the sealing portion 20, and a closing portion 30 provided at the other end. Of these, the body 12, the sealing portion 20, and the connecting portion 13 are each formed by deformation of the body 120 of the container body 110 when the opening 120a of the container body 110 described above is sealed.

[0055] The body portion 12 has a substantially cylindrical shape, and its horizontal cross section (a plane parallel to the XY plane) is substantially circular. Furthermore, the horizontal cross section of the body portion 12 is substantially uniform along the vertical direction (Z direction). The horizontal cross section of the body portion 12 is not limited to a circle, but may be a polygon such as a rectangle or a hexagon, or an ellipse. Furthermore, the connecting portion 13 is a cylindrical portion formed continuously from the body portion 12 toward the sealed portion 20, and its horizontal cross section gradually changes from the body portion 12 toward the sealed portion 20. In the illustrated example, the width of the connecting portion 13 gradually increases as it approaches the sealed portion 20 from the body portion 12. The body portion 12 and the connecting portion 13 are formed continuously and integrally with each other. In this embodiment, the container body 11 has a shape that is line-symmetrical in the left-right direction (X direction) when viewed from the front side (see FIG. 7).

[0056] The sealed portion 20 is a portion formed by sealing one end (the end on the positive side in the Z direction) of the container body 110 by heat sealing or the like. Specifically, the sealed portion 20 is formed by crushing one end of the barrel portion 120 of the container body 110, where the opening 120a is formed, and sealing the opposing inner surfaces of the end. The sealed portion 20 is generally planar, and its main surface has a generally rectangular shape parallel to the XZ plane. Examples of methods for sealing the sealed portion 20 include ultrasonic sealing, heat sealing, and high-frequency sealing. Alternatively, the inner surface of the container body 11 may be sealed by applying an adhesive. In this embodiment, a sealing method without using an adhesive is preferred, as this can prevent the adhesive from being mixed into the liquid.

[0057] The other end (the end on the negative side in the Z direction) of the container body 11 constitutes a closed closure portion 30. When in use, the liquid contained inside the container body 11 is taken out through the closing part 30. That is, by inserting a syringe needle or the like into the recess 31 of the closure part 30 and sucking up the liquid, it is possible to easily suck up the liquid from the liquid-filled container 40. The rest of the configuration of the closure part 30 is the same as that of the closure part 30 of the container body 110, so detailed description will be omitted here.

[0058] As described above, such a liquid-filled container 40 is formed by filling the container body 110 of the liquid storage container 10 with the liquid Lq, and then heat-sealing the open end of the container body 110 where the opening 120a is formed (i.e., forming the sealed portion 20). The liquid-filled container 40 can be positioned so that the sealed portion 20 faces vertically upward and the closing portion 30 faces vertically downward. Furthermore, such a liquid-filled container 40 may be used to store the liquid Lq in a frozen state.

[0059] When using the liquid-filled container 40, for example, as shown in Figure 8, the protective cover 70 is removed from the container body 11, and an injection needle 45 is inserted into the insertion surface 33 of the recess 31 of the closure part 30 to form an opening 34 in the closure part 30. Then, the injection needle 45 inserted into this opening 34 is used to aspirate the liquid Lq, and the liquid Lq inside the container body 11 can be extracted.

[0060] [Operation of this embodiment] Next, the operation of this embodiment having such a configuration will be described.

[0061] First, the container body 110 having the opening 120a formed at one end is produced by integral molding. At this time, a closed portion 30 is formed at the other end of the container body 110. In addition, a recess 31 is formed in this closed portion 30, in which the ratio of depth D to width W1 (D / W1) is greater than 0 and not greater than 0.1.

[0062] Next, a predetermined amount of liquid Lq is filled into the container body 110, and the end where the opening 120a is formed is heat-sealed to form the sealed portion 20. This results in a liquid-filled container 40 comprising the liquid storage container 10 and the liquid Lq stored in the liquid storage container 10 (see FIGS. 6 to 8).

[0063] Next, as shown in FIG. 9(a), the resulting liquid-filled container 40 is placed in a freezing device 100, and the liquid Lq is frozen and stored. At this time, first, the freezing device 100 is prepared. The freezing device 100 is filled with liquid nitrogen Ln. Next, the liquid-filled container 40 is immersed in the liquid nitrogen Ln. This causes the liquid Lq contained in the liquid-filled container 40 to freeze.

[0064] Incidentally, a protective cover 70 is attached to the closure portion 30 of the liquid storage container 10, and the recess 31 of the closure portion 30 is covered by the protective cover 70. Therefore, when the liquid-filled container 40 is immersed in liquid nitrogen Ln, the gas in the recess 31 is cooled, and the volume of the gas in the recess 31 decreases. This reduces the pressure inside the recess 31, and as shown in FIG. 9(b), the protective cover 70 deforms so as to be recessed toward the insertion surface 33 of the recess 31. Then, the protective cover 70 freezes in this deformed state so as to be recessed toward the insertion surface 33.

[0065] On the other hand, as shown in FIG. 10( a), a leak portion 73 that connects the inside and outside of the recess 31 may be formed in the protective cover 70. In this case, when the liquid-filled container 40 is immersed in liquid nitrogen Ln, the gas in the recess 31 is cooled, thereby reducing the volume of the gas in the recess 31. This reduces the pressure inside the recess 31, and as shown in FIG. 10( b), the liquid nitrogen Ln enters the recess 31 through the leak portion 73. Furthermore, as the pressure inside the recess 31 decreases, the protective cover 70 deforms so as to be recessed toward the insertion surface 33 of the recess 31. The protective cover 70 then freezes in this deformed state recessed toward the insertion surface 33, similar to when the leak portion 73 is not formed in the protective cover 70. Note that in this specification, the leak portion refers to a through-hole that connects the inside and outside of the recess 31 and has a diameter larger than the size of foreign matter or bacteria (for example, a particle size of about 1 μm).

[0066] In contrast, in the present embodiment, the ratio (D / W1) of the depth D to the width W1 of the recess 31 is greater than 0 and equal to or less than 0.1. As a result, when the liquid-filled container 40 is immersed in liquid nitrogen Ln to reduce the pressure inside the recess 31, the protective cover 70 is easily deformed so as to be recessed toward the insertion surface 33 of the recess 31 (see the imaginary line (two-dot chain line) in FIG. 4). This makes it possible to shorten the vertical (Z-direction) distance between the protective cover 70 and the insertion surface 33 of the recess 31. As a result, as shown in FIG. 10(c), the liquid nitrogen Ln that has entered the recess 31 comes into contact with the insertion surface 33 while being pressed toward the insertion surface 33 by the deformed protective cover 70. The insertion surface 33 is then at a temperature higher than that of the liquid nitrogen Ln. As a result, the liquid nitrogen Ln is pressed by the protective cover 70, which applies a stimulus, and the liquid nitrogen Ln that comes into contact with the insertion surface 33 of the recess 31 bumps, generating vapor bubbles (see the imaginary line (chain double-dashed line)) from the liquid nitrogen Ln, as shown in FIG. 10(d). These vapor bubbles then deform the protective cover 70 so that the protective cover 70 protrudes from the recess 31. Thereafter, the protective cover 70 freezes in the deformed state that protrudes from the recess 31.

[0067] As described above, in the present embodiment, when the liquid-filled container 40 is frozen with liquid nitrogen Ln, the protective cover 70, which has the leak portion 73 that connects the inside and outside of the recess 31, freezes in a deformed state so that it protrudes from the recess 31. That is, if the protective cover 70 is frozen in a deformed state so that it protrudes from the recess 31, it can be determined that the hygiene of the liquid storage container 10 may not be ensured. On the other hand, if the protective cover 70 is frozen in a deformed state so that it is recessed toward the insertion surface 33 of the recess 31, it can be determined that the hygiene of the liquid storage container 10 is ensured. For this reason, the hygiene of the liquid storage container 10 can be easily determined visually.

[0068] When removing the liquid Lq from the container body 11, first prepare the liquid-filled container 40 in which the liquid Lq is frozen. Next, visually check the condition of the protective cover 70. This allows the sanitation of the liquid storage container 10 to be visually checked. If the sanitation of the liquid storage container 10 is not ensured, the liquid-filled container 40 may be discarded. Alternatively, after removing the protective cover 70 from the container body 11, the insertion surface 33 of the recess 31 may be sterilized with alcohol or the like to maintain the sanitary quality of the insertion surface 33, and then the liquid Lq may be removed from the container body 11.

[0069] When the hygiene of the liquid storage container 10 is ensured, the protective cover 70 is removed from the closure part 30. Next, an opening 34 (see FIG. 8 ) that communicates with the interior is formed in the container body 11, and the liquid Lq in the container body 11 is removed from this opening 34. For example, as shown in FIG. 8 , an injection needle 45 is inserted into the insertion surface 33 of the recess 31 of the closure part 30 to form the opening 34 in the closure part 30, and the injection needle 45 inserted into this opening 34 is used to aspirate the liquid Lq and remove the liquid Lq from the container body 11. This makes it possible to remove the liquid Lq from the container body 11 without waste, even when the liquid Lq is an expensive medicinal liquid, which is economical. Furthermore, it is possible to extract an accurate amount of medicinal liquid from the container body 11. In this embodiment, a method for producing such a predetermined amount of medicinal liquid is also provided.

[0070] As described above, according to the present embodiment, the liquid storage container 10 includes the container body 110 having the closure portion 30 with the recess 31 recessed toward the body portion 120, and the protective cover 70 covering the recess 31 of the closure portion 30, wherein the ratio of the depth D to the width W1 (D / W1) of the recess 31 is greater than 0 and not greater than 0.1. Thus, by freezing the liquid storage container 10 with liquid nitrogen Ln, the protective cover 70, which has the leak portion 73 connecting the inside and outside of the recess 31, can be deformed into a predetermined shape. Furthermore, even when the protective cover 70 maintains the hygiene of the insertion surface 33 of the recess 31, the protective cover 70 can be deformed into a predetermined shape by freezing the liquid storage container 10 with liquid nitrogen Ln. Specifically, when the protective cover 70 has the leak portion 73 connecting the inside and outside of the recess 31, the protective cover 70 can be frozen in a deformed state so as to protrude from the recess 31. When the hygiene of the insertion surface 33 of the recess 31 is maintained by the protective cover 70, the protective cover 70 can be frozen in a deformed state so as to be recessed toward the insertion surface 33 of the recess 31. Therefore, when removing the liquid Lq contained in the liquid storage container 10, the hygiene of the liquid storage container 10 can be visually determined. Note that the ability to visually determine the hygiene of the liquid storage container 10 in this manner will be described in the examples below.

[0071] In the above-described embodiment, an example has been described in which the liquid-filled container 40 is immersed in liquid nitrogen Ln when freezing and storing the liquid Lq, but this is not limiting. For example, although not shown, the liquid Lq may be frozen by placing the liquid-filled container 40 in an ultra-low temperature freezer, or the liquid Lq may be frozen in the gas phase within a freezing device 100 filled with liquid nitrogen Ln. Even in these cases where the liquid Lq is frozen in the gas phase, if the protective cover 70 does not have a leak portion 73 that connects the inside and outside of the recess 31, the gas within the recess 31 is cooled, thereby reducing the volume of the gas within the recess 31. This reduces the pressure within the recess 31, and the protective cover 70 deforms so as to be recessed toward the insertion surface 33 of the recess 31. The protective cover 70 then freezes in this deformed state, recessed toward the insertion surface 33.

[0072] On the other hand, when the protective cover 70 has a leak portion 73 that connects the inside and outside of the recess 31, the protective cover 70 freezes without deformation. In other words, because the liquid-filled container 40 is not immersed in the liquid nitrogen Ln, bumping of the liquid nitrogen Ln does not occur in the recess 31. Therefore, the protective cover 70 does not freeze in a deformed state that protrudes from the recess 31. Furthermore, when the protective cover 70 has a leak portion 73 that connects the inside and outside of the recess 31, the pressure inside the recess 31 and the pressure outside the recess 31 become equal in the gas phase. Therefore, the protective cover 70 does not deform so as to recess toward the insertion surface 33 of the recess 31 due to reduced pressure inside the recess 31. In this way, when the liquid Lq is frozen using an ultra-low temperature freezer or the like, the protective cover 70, having the leak portion 73 that connects the inside and outside of the recess 31, frozen without deformation. Therefore, even if the liquid Lq is frozen using an ultra-low temperature freezer or the like, when the liquid Lq contained in the liquid storage container 10 is taken out, the hygienic state of the liquid storage container 10 can be visually determined.

[0073] [Variations] Next, various modified examples of the present disclosure will be described with reference to Figures 11 to 27. Figures 11 to 27 are views showing liquid storage containers according to various modified examples of the present disclosure. In Figures 11 to 27, the same parts as those shown in Figures 1 to 10 are designated by the same reference numerals, and detailed descriptions thereof will be omitted.

[0074] (First Modification) FIG. 11 shows a liquid storage container 10A according to a first modified example. In FIG. 11, a step portion 35 is formed on the side surface 32 of the recess 31. The depth d of the step portion 35 is shallower than the depth of the remaining portion of the recess 31. The depth d of the step portion 35 is 1.2 mm or less. The depth of the remaining portion of the recess 31 may be substantially constant throughout. That is, the depth of the portion of the recess 31 other than the step portion 35 may be equal to the depth D of the recess 31 at the center point CP throughout. In this modified example, if a leak portion 73 is formed in the protective cover 70, liquid nitrogen Ln that has entered the recess 31 through the leak portion 73 is pressed by the deformed protective cover 70 toward the step surface 35a of the step portion 35 and the side surface 32a of the side surface 32 that extends between the step surface 35a and the outer surface 30a of the closure portion 30. As a result, the liquid nitrogen Ln that has entered the recess 31 can be brought into contact with the step surface 35a and the side surface 32a while being pressed against the step surface 35a and the side surface 32a by the deformed protective cover 70. This allows the liquid nitrogen Ln that has entered the recess 31 to bump, and when removing the liquid Lq contained in the liquid storage container 10A, the sanitation of the liquid storage container 10A can be visually determined. Note that, in this specification, when a step portion 35 is formed on the side surface 32 of the recess 31, the depth d of the step portion 35 refers to the vertical distance from the outer surface 30a of the closure portion 30 to the step surface 35a of the step portion 35.

[0075] Furthermore, even if the ratio of depth D to width W1 (D / W1) of recess 31 is greater than 0.1, the depth d of step portion 35 is 1.2 mm or less, so that liquid nitrogen Ln that has entered recess 31 can be brought into contact with step surface 35a and side surface 32a while being pressed against step surface 35a and side surface 32a by deformed protective cover 70. This allows liquid nitrogen Ln that has entered recess 31 to bump, and the sanitation of liquid storage container 10A can be visually determined when removing liquid Lq stored in liquid storage container 10A.

[0076] (Second Modification) FIG. 12 shows a liquid storage container 10B according to a second modified example. In FIG. 12, the depth of the recess 31 gradually increases toward the center of gravity G1. In the illustrated example, the side surfaces 32 of the recess 31 are inclined with respect to the central axis CL of the container body 11 in a cross section taken along the central axis CL of the container body 11. In this modified example, the side surfaces 32 of the recess 31 are inclined so as to approach each other from the outer surface 30a toward the insertion surface 33 (the positive side in the Z direction). In this case, when the protective cover 70 deforms to recess toward the insertion surface 33 of the recess 31 due to reduced pressure inside the recess 31, the protective cover 70 can be deformed to follow the side surfaces 32 of the recess 31. In other words, the distance between the side surfaces 32 of the recess 31 and the protective cover 70 can be shortened compared to when the side surfaces 32 are parallel to the central axis CL in a cross section taken along the central axis CL of the container body 11. As a result, the deformed protective cover 70 can press the liquid nitrogen Ln that has entered the recess 31 toward the side surface 32 of the recess 31. This effectively stimulates the liquid nitrogen Ln that has entered the recess 31, thereby promoting the bumping of the liquid nitrogen Ln. Furthermore, even if a foreign object, for example, caused by the sealing layer 72 of the protective cover 70, gets into the recess 31, the foreign object can be easily removed. Furthermore, after the foreign object is removed, the insertion surface 33 can be easily disinfected with alcohol or the like.

[0077] (Third Modification) Fig. 13 shows a liquid storage container 10C according to a third modified example. In Fig. 13, similar to Fig. 12, the depth of the recess 31 gradually increases as it approaches the center of gravity G1. In the illustrated example, the inner surface 36 of the recess 31 is curved. In this case, as the pressure inside the recess 31 decreases, the protective cover 70 deforms so as to recess toward the inner surface 36 of the recess 31, allowing the protective cover 70 to deform to conform to the inner surface 36 of the recess 31. This allows the deformed protective cover 70 to easily press the liquid nitrogen Ln that has entered the recess 31 toward the inner surface 36 of the recess 31. This effectively stimulates the liquid nitrogen Ln that has entered the recess 31, thereby promoting the bumping of the liquid nitrogen Ln. Furthermore, even if foreign matter, for example, caused by the sealing layer 72 of the protective cover 70, enters the recess 31, the foreign matter can be easily removed. Furthermore, after the foreign matter is removed, the inner surface 36 can be easily sterilized with alcohol or the like. Note that when the inner surface 36 of the recess 31 is curved as in this modification, the side surface 32 and the insertion surface 33 of the recess 31 do not need to be distinguishable.

[0078] (Fourth Modification) FIG. 14 shows a liquid storage container 10D according to a fourth modification. In FIG. 14, the depth of the recess 31 includes a portion that gradually deepens as it approaches the center of gravity G1. In the illustrated example, the side surface 32 of the recess 31 is inclined with respect to the central axis CL of the container body 11 in a cross section taken along the central axis CL of the container body 11, and a step portion 35 is formed on the side surface 32 of the recess 31. Even in this case, the deformed protective cover 70 can press the liquid nitrogen Ln that has entered the recess 31 toward the side surface 32 and the step surface 35a of the recess 31. This effectively stimulates the liquid nitrogen Ln that has entered the recess 31, thereby promoting the bumping of the liquid nitrogen Ln.

[0079] (Fifth Modification) Fig. 15 shows a liquid storage container 10E according to a fifth modification. In Fig. 15, a groove 37 is formed in the recess 31, recessed toward the opening 120a (see Fig. 3) side relative to the insertion surface 33. In this case, even if foreign matter, for example, caused by the sealing layer 72 of the protective cover 70, gets into the recess 31, the foreign matter can be accommodated in the groove 37 and removed from the insertion surface 33. This ensures hygiene of the insertion surface 33.

[0080] (Sixth Modification) Fig. 16 shows a liquid storage container 10F according to a sixth modified example. In Fig. 16, the closure portion 30 is thinned from the inside (positive side in the Z direction) of the container body 11 at a position corresponding to the insertion surface 33 of the recess 31. In this case, the thickness of the region where the insertion surface 33 is located can be further reduced. This makes it even easier for the injection needle 45 to penetrate the closure portion 30 when aspirating the liquid Lq, which is the contents, with the injection needle 45.

[0081] (Seventh Modification) 17 and 18 show a liquid storage container 10G according to a seventh modified example. In FIGS. 17 and 18, the center of gravity G1 (see FIG. 17) is located at a position that does not overlap with the center of gravity G2 of the closure portion 30 in a bottom view (the center of gravity of the planar figure in which the outline of the closure portion 30 forms the outer edge when viewed from the depth direction (Z direction) of the recess 31). In this modified example, the center of gravity G1 is located at a position that does not overlap with the central axis CL. Also, in the illustrated example, the recess 31 is formed at a position that does not overlap with the center of gravity G2 of the closure portion 30 in a bottom view. In this way, by locating the center of gravity G1 at a position that does not overlap with the center of gravity G2 of the closure portion 30 in a bottom view, it is possible to reduce the area of ​​the portion of the protective cover 70 that is removed from the container body 11 when exposing the recess 31 of the container body 11, as shown in FIG. Therefore, foreign matter originating from the seal layer 72 of the protective cover 70 removed from the container body 11 can be further prevented from entering the recess 31.

[0082] Furthermore, in this modification, the protective cover 70 is provided with a flange 74 that extends to a position that does not overlap with the closure portion 30 in a bottom view (when viewed from the depth direction (Z direction) of the recess 31). In the illustrated example, the protective cover 70 is provided with a flange 74 that extends radially outward from the closure portion 30. This allows the protective cover 70 to be easily removed from the container body 11. Furthermore, at least a portion of the flange 74 is located on a straight line L2 that connects the center of gravity G1 and the center of gravity G2 of the closure portion 30. This allows the position of the recess 31 to be easily determined.

[0083] (Eighth Modification) 19 and 20 show a liquid storage container 10H according to an eighth modification. In FIGS. 19 and 20, the recess 31 is provided with a mark 38 indicating the position of the region where the thickness of the closure portion 30 is equal to or less than a predetermined thickness. This mark 38 protrudes from the insertion surface 33 of the recess 31 toward the outer surface 30a of the recess 31 (the negative Z-direction side) so as to surround the region of the insertion surface 33 of the recess 31 where the thickness of the closure portion 30 is equal to or less than the predetermined thickness. This mark 38 has a generally annular shape in bottom view. Thus, by providing the recess 31 with the mark 38 indicating the position of the region where the thickness of the closure portion 30 is equal to or less than the predetermined thickness, the user can easily identify the region where the thickness of the closure portion 30 is equal to or less than the predetermined thickness. This makes it easier for the injection needle 45 to pierce the region where the thickness of the closure portion 30 is equal to or less than the predetermined thickness. This makes it easier for the injection needle 45 to penetrate the closure portion 30. The thickness of the region where the mark 38 indicates its position may be, for example, 0.35 mm or less, and preferably 0.3 mm or less. Although the example in which the mark 38 has a substantially annular shape in bottom view has been described, this is not limiting. For example, as shown in FIG. 21 , multiple markings 38 may be provided on the closure portion 30. In the illustrated example, three markings 38 are provided on the closure portion 30, and each marking 38 is disposed at equal intervals so as to surround a region of the insertion surface 33 where the thickness of the closure portion 30 is equal to or less than a predetermined thickness. The number of markings 38 may be two or less, or four or more.

[0084] (Ninth Variation) 22 shows a liquid storage container 10I according to a ninth modified example. In FIG. 22, the width W2 of the inner surface 121 of the body 120 gradually narrows as it approaches the closure part 30. In the illustrated example, the inner surface 121 of the body 120 is inclined with respect to the central axis CL of the container body 11 in a cross section taken along the central axis CL of the container body 11. In this modified example, the inner surfaces 121 of the body 120 are inclined so as to approach each other from the opening 120a side toward the closure portion 30 side (the negative side in the Z direction). In this case, it is possible to prevent liquid from remaining in the liquid storage container 10I when the liquid stored in the liquid storage container 10I is taken out.

[0085] Generally, when extracting liquid from a container containing the liquid, there are several methods, such as inserting a syringe needle into the container and aspirating the liquid, or removing a lid that seals the container and extracting the liquid. When inserting a syringe needle into the container to aspirate the liquid, as shown in FIG. 22 , it is common to tilt the liquid storage container 10I so that the closure portion 30 faces downward, and insert the syringe needle 45 into the insertion surface 33 from below. However, depending on the shape of the liquid storage container, a corner 122 (see the imaginary line (two-dot chain line) in FIG. 22 ) where the liquid Lq can accumulate may be formed at the boundary between the inner surface 121 of the body portion 120 and the inner surface 30b of the closure portion 30. In this case, it has been found that the liquid may remain in the corner 122, making it difficult to extract the liquid sufficiently. This problem becomes particularly pronounced when the liquid stored in the liquid storage container 10I is expensive or when all of the liquid stored in the liquid storage container 10I must be administered. As a result of extensive research into these issues, the inventors have discovered that by adjusting the shape of inner surface 121 of body portion 120, it is possible to prevent corners 122 where liquid remains from being formed, thereby solving the above-mentioned problem. This modified example was made based on this knowledge, and the above-mentioned problem can be solved by gradually narrowing width W2 of inner surface 121 of body portion 120 as it approaches closure portion 30.

[0086] (Tenth Modification) Fig. 23 shows a liquid storage container 10J according to a tenth modified example. In Fig. 23, similar to Fig. 22, the width W2 of the inner surface 121 of the body portion 120 gradually narrows as it approaches the closure portion 30. In the illustrated example, the inner surface 121 of the body portion 120 is curved. Even in this case, when the liquid contained in the liquid storage container 10J is taken out, it is possible to prevent the liquid from remaining inside the liquid storage container 10J. Furthermore, because the inner surface 121 of the body 120 is curved, it is possible to prevent the formation of corners 123 (see the imaginary line (two-dot chain line) in FIG. 23) on the inner surface 121 of the body 120, where the liquid Lq may accumulate. Therefore, it is possible to more effectively prevent the liquid from remaining inside the liquid storage container 10J when the liquid contained in the liquid storage container 10J is taken out.

[0087] (Eleventh Modification) Fig. 24 shows a liquid storage container 10K according to an eleventh modification. In Fig. 24, the liquid storage container 10K further includes a bag 130 attached to the trunk 120 of the container body 110 and closing the opening 120a, and a communication member 140 attached to the bag 130 and connecting the inside and outside of the bag 130.

[0088] Of these, the communicating member 140 has a substantially cylindrical shape, and its horizontal cross section (a plane parallel to the XY plane) is substantially circular. The horizontal cross section of the communicating member 140 is substantially uniform along the vertical direction (Z direction). A through-hole 140a is formed in the communicating member 140, extending from one end (the end on the positive side in the Z direction) to the other end (the end on the negative side in the Z direction). The horizontal cross section of the communicating member 140 is not limited to a circle, and may be a polygon such as a square or a hexagon, or an ellipse.

[0089] The material constituting the communicating member 140 may be any material that can be sealed. For example, the same material as the material constituting the container body 110 may be selected as the material constituting the communicating member 140.

[0090] This liquid storage container 10K can be used, for example, as a cell culture bag for storing biological cells, a cell cryopreservation bag for storing and freezing biological cells, a blood bag for storing blood or blood components, an IVH bag for storing nutrients for direct administration to a central vein, etc., an infusion bag for storing liquids for intravenous drip, a bag for storing enteral nutrients, and various other bags for storing various liquids.

[0091] Next, a liquid container 40A including a liquid storage container 10K according to this modified example will be described with reference to Fig. 25. As shown in Fig. 25, the liquid container 40A includes the liquid storage container 10K described above and liquid Lq stored in a bag 130. Here, in the liquid container 40A, the communication member 140 of the liquid storage container 10K is sealed.

[0092] When producing such a liquid-filled container 40A, first, a predetermined amount of liquid Lq is filled into the bag 130 through the through-hole 140a. Next, one end of the communicating member 140 is heat-sealed to seal the communicating member 140. This results in a liquid-filled container 40A that includes the liquid storage container 10K, the liquid Lq stored in the bag 130, and the communicating member 140 that is sealed.

[0093] When using the liquid-filled container 40A, the protective cover 70 can be removed from the container body 110, and the injection needle 45 can be inserted into the recess 31 of the closure part 30 to aspirate the liquid Lq, thereby removing the liquid Lq from the bag 130.

[0094] (12th Modification) Figure 26 shows a liquid storage container 10L according to a twelfth modified example. In Figure 26, a communicating member 140A includes a first tube 141 attached to a bag 130 and two second tubes 142a, 142b branching off from the first tube 141. Note that, although in Figure 26, the communicating member 140A includes the first tube 141 and the two second tubes 142a, 142b branching off from the first tube 141, the present invention is not particularly limited to this and any known liquid extraction means can be used.

[0095] Of the two second tubes 142a and 142b, one second tube 142a is provided with a first clamp 143 for closing the flow path of the liquid Lq. A liquid sampling needle 144 is connected to the tip of the second tube 142a.

[0096] The other second tube 142b is provided with a second clamp 145 for closing the flow path of the liquid Lq. A connector 146 is connected to the tip of the second tube 142b.

[0097] Next, a liquid container 40B including a liquid storage container 10L according to this modified example will be described with reference to Figure 27. As shown in Figure 27, the liquid container 40B includes the liquid storage container 10L described above and liquid Lq stored in a bag 130. Here, in the liquid container 40B, the communicating member 140A of the liquid storage container 10L is sealed. Specifically, the first tube 141 of the communicating member 140A of the liquid storage container 10L is sealed, and the first tube 141 is cut midway.

[0098] When producing such a liquid-filled container 40B, first, a predetermined amount of liquid Lq is filled into the bag 130. In this case, the liquid Lq is filled into the bag 130 using the liquid collection needle 144 or the connector 146. For example, when filling the bag 130 with the liquid Lq using the liquid collection needle 144, first, the flow path of the liquid Lq is closed, for example, by closing the first clamp 143 and the second clamp 145. Then, the liquid collection needle 144 is pierced into a bag (not shown) containing the liquid Lq, and the first clamp 143 is opened. Thereafter, the liquid Lq is sucked through the liquid collection needle 144, thereby filling the bag 130 with a predetermined amount of liquid Lq.

[0099] On the other hand, when filling bag 130 with liquid Lq using connector 146, first, for example, first clamp 143 and second clamp 145 are closed to close the flow path of liquid Lq. Then, a syringe or the like (not shown) containing liquid Lq is connected to connector 146, and second clamp 145 is opened. After that, a predetermined amount of liquid Lq is filled into bag 130 from the syringe or the like via connector 146.

[0100] Thereafter, the opened clamp (first clamp 143 or second clamp 145) is closed, and the first tube 141 is then sealed. Next, the first tube 141 is cut midway. This results in a liquid-filled container 40A that includes the liquid storage container 10L and the liquid Lq stored in the bag 130, and that has the communicating member 140A sealed.

[0101] When using the liquid-filled container 40B, the protective cover 70 can be removed from the container body 110, and the injection needle 45 can be inserted into the recess 31 of the closure part 30 to aspirate the liquid Lq, thereby removing the liquid Lq from the bag 130.

[0102] (13th Modification) FIG. 28 shows a liquid storage container 10M according to a thirteenth modification. In FIG. 28, the body 120 of the liquid storage container 10M includes a first body 125 located on the first portion 10a side and a second body 126 located closer to the second portion 10b than the first body 125. The width W3 of the inner surface 126a of the second body 126 gradually narrows as it approaches the closure portion 30 from the first body 125. This allows the liquid Lq to be temporarily stored near an intersection P1 between the inner surface 125a of the first body 125 and the inner surface 126a of the second body 126 in a cross section in a plane (XZ plane) including the central axis CL of the container body 110. In other words, when the remaining amount of the liquid Lq becomes low, the liquid Lq can be temporarily collected near the intersection P1, allowing the liquid Lq to be efficiently sucked.

[0103] In this modified example, in a cross section taken along a plane including the central axis CL, the inner surface 126a of the second body 126 is inclined relative to the inner surface 125a of the first body 125 so as to fit the shape of the injection needle RB, which will be described later. This makes it possible to prevent liquid from remaining in the liquid storage container 10M, as will be described later. Note that in this modified example, the inner surface 126a of the second body 126 is inclined relative to the inner surface 125a of the first body 125 over the entire circumference of the container body 110. In other words, the inner surface 126a of the second body 126 is located radially inward of the inner surface 125a of the first body 125 over the entire circumference of the container body 110.

[0104] Furthermore, in a cross section taken along a plane including the central axis CL, when an imaginary line (first imaginary line) IL1 is drawn that passes through an intersection P1 between the inner surface 125a of the first body portion 125 and the inner surface 126a of the second body portion 126 and intersects with the inner surface 30b of the closure portion 30, the angle α1 formed by the imaginary line IL1 and the inner surface 125a of the first body portion 125 is equal to or greater than 168° and less than 180°. Here, the imaginary line IL1 may be a line that does not intersect with the inner surface 126a of the second body portion 126 and has the shortest length from the intersection P1 to the inner surface 30b of the closure portion 30.

[0105] Furthermore, the length Lx1 of the imaginary straight line IL1 from the intersection point P1 to the insertion surface (bottom surface) 33 of the recess 31 may be 32.10 mm or less. As a result, in the liquid storage container 10M according to this modification, when an injection needle with a gauge of 18 (18G) is used, as will be described later, it is possible to prevent liquid from remaining inside the liquid storage container 10M.

[0106] Here, hospitals typically use syringe needles of different diameters depending on the purpose of use. For example, the gauge of a syringe needle used for blood collection is 21 (21G, needle outer diameter: 0.80 mm), and the gauge of a syringe needle used for intravenous drip is 20 (20G, needle outer diameter: 0.90 mm) to 23 (23G, needle outer diameter: 0.60 mm). Furthermore, a syringe needle with a gauge of 18 (18G, needle outer diameter: 1.20 mm) may be used when withdrawing a liquid (medicine) from a container containing the liquid (when aspirating the medicine). Furthermore, syringe needles used in hospitals include a regular bevel (RB) syringe needle (hereinafter simply referred to as the RB syringe needle) with a cutting edge angle β1 of 12° as shown in FIG. 29, and a short bevel (SB) syringe needle (hereinafter simply referred to as the SB syringe needle) with a cutting edge angle β2 of 18° as shown in FIG. 30. Examples of these injection needles include Terumo injection needle NN-1838R (product name) and Terumo injection needle NN-1838S (product name) manufactured by Terumo Corporation, and Flowmax 18GX1 1 / 2RBGA (product name) and Flowmax 18GX1 1 / 2SBGA (product name) manufactured by Nipro Corporation.

[0107] Incidentally, when the drug is a cell preparation, it is required to reduce stress on the cells during aspiration. Here, an 18G injection needle has a larger bore than the above-mentioned 20G injection needle. As a result, by aspirating the drug, which is a cell preparation, with an 18G injection needle, stress on the cells during aspiration can be reduced. For this reason, 18G injection needles are actively used when aspirating drugs related to regenerative medicine, etc. Therefore, there is a demand for a container that can reduce liquid residue in the container when an 18-gauge (18G) injection needle is used. This modification can provide a liquid storage container 10M that can reduce liquid residue when an 18-gauge (18G) injection needle is used.

[0108] Next, the reason why the use of an 18G injection needle can prevent liquid from remaining in the liquid storage container 10M will be described. In the following description, as shown in FIG. 29, the outer diameter of the injection needle RB is defined as Gr and the length as Lr. Therefore, the length from the tip R1 of the injection needle RB to the base end R3 of the blade surface R2 can be expressed as Gr / tan(12°), and the length of the region of the injection needle RB where the blade surface R2 is not formed can be expressed as Lr - (Gr / tan(12°)). In the following description, as shown in FIG. 30, the outer diameter of the injection needle SB is defined as Gs and the length as Ls. Therefore, the length from the tip S1 of the injection needle SB to the base end S3 of the blade surface S2 can be expressed as Gs / tan(18°), and the length of the region of the injection needle SB where the blade surface S2 is not formed can be expressed as Ls - (Gs / tan(18°)).

[0109] First, as described above, the angle α1 (see FIG. 28) formed between the imaginary line IL1 and the inner surface 125a of the first barrel 125 is equal to or greater than 168° and less than 180°. This allows the injection needle RB to be placed in a position (hereinafter simply referred to as a stable position) where the base end R3 of the injection needle RB contacts the intersection P1 and where the formation of a gap between the blade surface R2 of the injection needle RB and the inner surface 125a of the first barrel 125 can be suppressed, as shown in FIG. 31. In this stable position, the base end R3 of the injection needle RB contacts the intersection P1 and the formation of a gap between the blade surface R2 of the injection needle RB and the inner surface 125a of the first barrel 125 is suppressed, so that the liquid Lq collected near the intersection P1 can be efficiently sucked up.

[0110] Here, if the length Lx1 of the imaginary straight line IL1 from the intersection point P1 to the insertion surface 33 of the recess 31 becomes too long, it becomes difficult to place the injection needle RB in a stable position. In other words, if the length Lx1 of the imaginary straight line IL1 is equal to or less than a predetermined length, the injection needle RB can be placed in a stable position even when the injection needle RB is inserted to the deepest point into the container body 110 (11). Here, as shown in FIG. 32, when the injection needle RB is inserted to the deepest point into the container body 110 (11) and placed in a stable position, the length Lx1 of the imaginary straight line IL1 can be expressed by the following formula (1): Lx1=Lr-(Gr / tan(12°))-Gr×tan(12°)...Equation (1) Therefore, by setting the length Lx1 to be equal to or less than the value of the above formula (1), the injection needle RB can be placed in a stable position, and the contents can be efficiently sucked in. As a result, the amount of liquid remaining in the liquid storage container 10M can be reduced.

[0111] Incidentally, in the case of an injection needle RB with a gauge of 18 (18G, needle outer diameter (Gr): 1.20 mm), an injection needle with a needle length (Lr) of 38 mm is commonly used. Therefore, by setting Gr to 1.20 mm and Lr to 38 mm and substituting each value into equation (1), we obtain Lx1 = 32.10 mm.

[0112] Therefore, the angle α1 formed by the imaginary straight line IL1 and the inner surface 125a of the first barrel portion 125 is equal to or greater than 168° and less than 180°, and the length Lx1 of the imaginary straight line IL1 from the intersection point P1 to the insertion surface 33 of the recess 31 is equal to or less than 32.10 mm, so that when an injection needle RB with a gauge of 18 (18G) is used, the contents can be efficiently aspirated.

[0113] 32, even when a short-bevel injection needle SB is used, the injection needle SB can be placed in a position (hereinafter simply referred to as a stable position) where the base end S3 of the injection needle SB comes into contact with the intersection point P1 and where formation of a gap between the blade surface S2 of the injection needle SB and the inner surface 125a of the first barrel 125 can be prevented. Therefore, even when the injection needle SB is used, the contents can be efficiently aspirated.

[0114] Here, as shown in FIG. 32, when the injection needle SB is placed in a stable position, the length Lx2 along the longitudinal direction of the injection needle SB from the intersection point P1 to the insertion surface 33 of the recess 31 can be expressed by the following equation (2): Lx2=Lx1×(cos(12°) / cos(18°))...Equation (2) That is, Lx2 can be expressed by the following formula (2)'. Lx2={Lr-(Gr / tan(12°))-Gr×tan(12°)}×(cos(12°) / cos(18°))...Equation (2)'

[0115] On the other hand, if the above-mentioned length Lx2 becomes too long, it becomes difficult to place the injection needle SB in a stable position. In other words, if the length Lx2 is equal to or less than a predetermined length, the injection needle SB can be placed in a stable position even when the injection needle SB is inserted to the deepest point into the container body 11 (110). Here, as shown in Figure 33, when the injection needle SB is inserted to the deepest point into the container body 11 (110) and placed in a stable position, the length Lx2 can be expressed by the following formula (3): Lx2=Ls-(Gs / tan(18°))-Gs×tan(18°)...Equation (3) Therefore, by selecting an injection needle SB whose length Lx2 is equal to or less than the value of the above formula (3), even when a short-bevel injection needle SB is used, the injection needle SB can be placed in a stable position and the contents can be efficiently aspirated.

[0116] Incidentally, in the case of an injection needle SB with a gauge of 18 (18G, needle outer diameter (Gs): 1.20mm), an injection needle with a needle length (Ls) of 38mm is often used. Therefore, by setting Gs to 1.20mm and Ls to 38mm and substituting each value into equation (3), we obtain Lx2 = 33.92mm. Therefore, by setting the length Lx2 to 33.92mm or less, when an injection needle SB with a gauge of 18 (18G) is used, the contents can be efficiently aspirated.

[0117] Furthermore, substituting Lx1 = 32.10 mm into the above formula (2) yields Lx2 = 33.01 mm. That is, Lx2 is 33.92 mm or less. Therefore, since the angle α1 between the imaginary line IL1 and the inner surface 125a of the first barrel portion 125 is 168° or more and less than 180°, and the length Lx1 of the imaginary line IL1 from the intersection point P1 to the insertion surface 33 of the recess 31 is 32.10 mm or less, the contents can be efficiently aspirated both when an 18-gauge (18G) injection needle RB is used and when an 18-gauge (18G) injection needle SB is used.

[0118] In this modification, it is preferable that the imaginary line IL1 intersects with the insertion surface (bottom surface) 33 of the recess 31. This can prevent the injection needle RB from interfering with the recess 31. Referring again to FIG. 31, in the cross section in the plane including the central axis CL, when an imaginary line IL11 is drawn from the intersection point P1 toward the first portion 10a (left side of FIG. 31) through a point P11 away from the intersection point P1 by the length of the blade surface R2 (i.e., Gr / sin(β1)), and the angle α11 it forms with the inner surface 125a of the first barrel 125 is 180°-β1, it is preferable that the imaginary line IL11 intersects with the opening edge 31a of the recess 31. This can prevent the injection needle RB from interfering with the recess 31. In this case, for example, in the case of an injection needle RB with a gauge of 18 (18G, needle outer diameter (Gr): 1.20 mm, blade angle β1: 12°), the length of the blade surface R2 is 5.77 mm. Therefore, the point P11 is a point that is 5.77 mm away from the intersection point P1 toward the first portion 10a.

[0119] 33 again, in the cross section on the plane including the central axis CL, when an imaginary line (second imaginary line) IL2 is drawn from the intersection point P1 toward the first portion 10a, passing through point P2 away from the intersection point P1 by the length of the blade surface S2 (i.e., Gs / sin(β2)), and forming an angle α2 of 180°-β2 with the inner surface 125a of the first barrel portion 125, it is preferable that the imaginary line IL2 intersects with the opening edge 31a of the recess 31. This prevents the injection needle SB from interfering with the recess 31. In this case, for example, in the case of an injection needle SB with a gauge of 18 (18G, needle outer diameter (Gr): 1.20 mm, blade angle β2: 18°), the length of the blade surface S2 is 3.88 mm. Therefore, point P2 is located 3.88 mm away from the intersection point P1 toward the first portion 10a (left side of FIG. 33). In this way, when an imaginary straight line IL2 can be drawn in a cross section in a plane including the central axis line CL so that the injection needle SB does not interfere with the recess 31, it is possible to prevent the injection needles RB and SB from interfering with the recess 31 regardless of whether the injection needle RB or the injection needle SB is used.

[0120] As described above, according to this modification, in a cross section taken along a plane including the central axis CL of the container body 110, the angle α1 formed by the imaginary line IL1 and the inner surface 125a of the first barrel portion 125 is 168° or more and less than 180°. In addition, the length Lx1 of the imaginary line IL1 from the intersection P1 to the insertion surface (bottom surface) 33 of the recess 31 is 32.10 mm or less. This makes it possible to prevent liquid from remaining in the liquid storage container 10M when an injection needle with a gauge of 18 (18G) is used.

[0121] Furthermore, according to this modification, in a cross section on a plane including the central axis CL of the container body 110, the imaginary line IL2 intersects with the opening edge 31a of the recess 31. This makes it possible to prevent the injection needle SB from interfering with the recess 31. In this case, whether the injection needle RB or the injection needle SB is used, it is possible to prevent the injection needles RB and SB from interfering with the recess 31.

[0122] As an example, the values ​​of the dimensions of injection needles that can be used in hospitals are shown in Table 1 below. The values ​​of the above formulas (1) to (3) and the length of the cutting edge S2 (ie, Gs / sin(18°)) of injection needles that can be used in hospitals are shown in Table 2 below.

[0123] [Table 1]

[0124] [Table 2]

[0125] When only a short-bevel injection needle SB is used without using a regular-bevel injection needle RB, the angle α1 (see FIG. 28) formed between the imaginary line IL1 and the inner surface 125a of the first barrel portion 125 may be equal to or greater than 162° and less than 180°.

[0126] (14th Modification) FIG. 34 shows a liquid storage container 10N according to a fourteenth modification. In FIG. 34, in a cross section taken along a plane including the central axis CL, the angle formed between the inner surface 125a of the first body 125 and the inner surface 126a of the second body 126 may change as the distance from the first body 125 approaches the closure portion 30. In the example shown, the second body 126 includes a first region 126b and a second region 126c that is located closer to the second portion 10b than the first region 126b. In the second region 126c, the angle formed between the inner surface 125a of the first body 125 and the inner surface 126a of the second body 126 is larger than the angle formed between the inner surface 125a and the inner surface 126a in the first region 126b. In this case, the liquid Lq can also be efficiently sucked.

[0127] (15th Modification) Fig. 35 shows a liquid storage container 10O according to a fifteenth modification. In Fig. 35, in a cross section taken along a plane including the central axis CL, a portion of the inner surface 126a of the second body 126 does not have to be inclined with respect to the inner surface 125a of the first body 125. In other words, only a portion of the inner surface 126a of the second body 126 may be inclined with respect to the inner surface 125a of the first body 125. Even in this case, the liquid Lq can be efficiently sucked up, and it is possible to prevent the liquid from remaining in the liquid storage container 10O.

[0128] (16th Modification) Figure 36 shows a liquid storage container 10P according to a sixteenth modification. In Figure 36, the closure portion 30 does not necessarily have to be formed with a recess 31 recessed toward the body portion 120. In this case, the liquid storage container 10P includes a container body 110 having a hollow body portion 120 with an opening 120a formed in a first portion 10a, and a closure portion 30 provided in a second portion 10b of the body portion 120. The liquid storage container 10P may also include a protective cover 70 that covers the closure portion 30.

[0129] In this modified example, the liquid Lq contained in the liquid storage container 10P may be sucked from the liquid storage container 10P by inserting an injection needle or the like into the closure portion 30 and sucking the liquid. In this case, the thickness T2 of the closure portion 30 is preferably 0.5 mm or less, and more preferably 0.3 mm or less. By making the thickness T2 of the closure portion 30 0.5 mm or less, it is possible to prevent the injection needle from scraping off part of the closure portion 30 when the injection needle is inserted into the closure portion 30, which is known as coring.

[0130] In this modified example as well, the liquid Lq can be efficiently sucked up, and the liquid can be prevented from remaining in the liquid storage container 10P. In this case, the imaginary line IL11 (see FIG. 31) intersects with the inner surface 30b of the closure portion 30, thereby preventing the injection needle RB from interfering with the second barrel portion 126 of the barrel portion 120. Furthermore, the imaginary line IL2 intersects with the inner surface 30b of the closure portion 30, thereby preventing the injection needle SB from interfering with the second barrel portion 126 of the barrel portion 120.

[0131] (17th Variation) Fig. 37 shows a liquid storage container 10Q according to a seventeenth modification. In Fig. 37, a thin-walled portion 311 may be provided in a portion of the closure portion 30. In this case, the liquid storage container 10Q includes a container body 110 having a hollow body portion 120 with an opening 120a formed in a first portion 10a, and a closure portion 30 provided in a second portion 10b of the body portion 120. The thin-walled portion 311 is provided in a portion of the closure portion 30. The liquid storage container 10Q may also include a protective cover 70 that covers the closure portion 30.

[0132] In this modified example, the liquid Lq contained in the liquid storage container 10Q may be sucked from the liquid storage container 10Q by inserting an injection needle or the like into the thin-walled portion 311 and sucking the liquid. The thickness T3 of this thin-walled portion 311 is preferably 0.5 mm or less, and more preferably 0.3 mm or less. By making the thickness T3 of the thin-walled portion 311 0.5 mm or less, it is possible to prevent the injection needle from scraping off a part of the thin-walled portion 311 when inserting the thin-walled portion 311, which is known as coring.

[0133] In this modification, the imaginary line (first imaginary line) IL1 can be drawn so as to pass through the intersection point P1 and intersect with a portion of the outer surface 30a of the closure portion 30 that overlaps with the thin-walled portion 311 of the closure portion 30 when viewed from the thickness direction (Z direction) of the closure portion 30. In this case, the imaginary line IL1 may be a line that does not intersect with either the inner surface 126a of the second body portion 126 or the inner surface 30b of the closure portion 30 between the intersection point P1 and the inner surface 311a of the thin-walled portion 311 in a cross section taken along a plane including the central axis CL, and has the shortest length from the intersection point P1 to the inner surface 311a of the thin-walled portion 311. Furthermore, in this case, the length Lx1 of the imaginary line IL1 may be the distance from the intersection point P1 to the outer surface 30a of the closure portion 30, and may be 32.10 mm or less.

[0134] In this modification as well, the liquid Lq can be efficiently sucked up, and the liquid can be prevented from remaining in the liquid storage container 10Q. In this case, the imaginary line IL11 (see FIG. 31) intersects with the inner surface 311a of the thin-walled portion 311, thereby preventing the injection needle RB from interfering with the second barrel portion 126 of the barrel portion 120 and the closure portion 30. Furthermore, the imaginary line IL2 intersects with the inner surface 311a of the thin-walled portion 311, thereby preventing the injection needle SB from interfering with the second barrel portion 126 of the barrel portion 120 and the closure portion 30.

[0135] (18th Variation) Figure 38 shows a liquid-filled container 40C according to an eighteenth modification. In Figure 38, container body 11 (container body 110 with opening 120a sealed) of liquid-filled container 40C has, like liquid-filled container 40 described above, a cylindrical body portion (cylindrical portion) 12, a sealed portion 20 formed at one end, a connecting portion 13 formed continuously between body portion 12 and sealed portion 20, and a closure portion 30 provided at the other end. The width of connecting portion 13 gradually increases from body portion 12 toward sealed portion 20.

[0136] In this modification, when an imaginary line (third imaginary line) IL3 is drawn in a cross section in a plane including the central axis of the container body 11 (i.e., the central axis CL of the container body 110), intersecting with the insertion surface (bottom surface) 33 of the recess 31 and the inner edge 20a of the sealing portion 20, the length Lx3 of the imaginary line IL3 from the insertion surface 33 of the recess 31 to the inner edge 20a of the sealing portion 20 may be 38 mm or less. Here, the imaginary line IL3 is a line that does not intersect with either the inner surface 12a of the barrel portion 12 or the inner surface 13a of the connecting portion 13.

[0137] According to this modification, when the liquid Lq contained in the liquid container 40C is taken out, it is possible to prevent the liquid Lq from remaining in the liquid container 40C. That is, when the remaining amount of the liquid Lq becomes small, the liquid Lq can be collected at a position that the injection needle can reach. In other words, even if the remaining amount of the liquid Lq becomes small and some of the liquid Lq remains at the corner 15 at the boundary between the inner surface 13a of the connecting portion 13 and the inner edge 20a of the sealed portion 20, it is possible to insert an injection needle with a gauge of 18 (18G, needle outer diameter: 1.20 mm) up to the vicinity of the corner 15. This allows the liquid Lq to be efficiently aspirated even when the remaining amount of the liquid Lq becomes small. Therefore, it is possible to prevent the liquid Lq from remaining in the liquid container 40C.

[0138] (19th Variation) Figure 39 shows a liquid container 40D according to a nineteenth modification. In Figure 39, the closure 30 does not necessarily have to be formed with a recess 31 recessed toward the body 120. In this case, the liquid container 40D includes a liquid storage container 10R and a liquid Lq stored in the liquid storage container 10R. The liquid storage container 10R includes a container body 110 having a hollow body 120 with an opening 120a formed in a first portion 10a, and a closure 30 provided in a second portion 10b of the body 120.

[0139] In this modified example, the liquid Lq may be sucked from the liquid-filled container 40E by inserting a syringe needle or the like into the closure portion 30 and sucking the liquid. Even in this case, the thickness T2 of the closure portion 30 is preferably 0.5 mm or less, and more preferably 0.3 mm or less. By setting the thickness T2 of the closure portion 30 to 0.5 mm or less, it is possible to prevent the occurrence of so-called coring, in which the syringe needle scrapes off part of the closure portion 30 when the syringe needle is inserted into the closure portion 30.

[0140] Furthermore, in this modified example, the imaginary line (third imaginary line) IL3 can be drawn so as to intersect with the portion of the outer surface 30a of the closure portion 30 that overlaps with the inner surface 30b of the closure portion 30 and the inner edge 20a of the sealing portion 20 when viewed from the thickness direction (Z direction) of the closure portion 30 in a cross section in a plane including the central axis line of the container body 11 (i.e., the central axis line CL of the container body 110). In this case, the length Lx3 of the imaginary line IL3 may be the distance from the outer surface 30a of the closure portion 30 to the inner edge 20a of the sealing portion 20, and may be 38 mm or less.

[0141] In this modified example, the liquid Lq can also be efficiently sucked, and the liquid remaining in the liquid container 40E can be reduced.

[0142] (20th Variation) Figure 40 shows a liquid-filled container 40E according to a twentieth modification. In Figure 40, a thin-walled portion 311 may be provided in part of the closure 30. In this case, the liquid-filled container 40E includes a liquid storage container 10S and a liquid Lq stored in the liquid storage container 10S. The liquid storage container 10S includes a container body 110 having a hollow body 120 with an opening 120a formed in a first portion 10a, and a closure 30 provided in a second portion 10b of the body 120.

[0143] In this modification, the liquid Lq may be sucked from the liquid-filled container 40F by inserting a syringe needle or the like into the thin-walled portion 311 and sucking the liquid. In this case, too, the thickness T3 of the thin-walled portion 311 is preferably 0.5 mm or less, and more preferably 0.3 mm or less. By making the thickness T3 of the thin-walled portion 311 0.5 mm or less, it is possible to prevent the syringe needle from scraping off a portion of the thin-walled portion 311 when piercing it, which is known as coring.

[0144] In this modification, the imaginary line (third imaginary line) IL3 can be drawn so as to intersect with the portion of the outer surface 30a of the closure portion 30 that overlaps with the thin-walled portion 311 and the inner edge 20a of the sealing portion 20 when viewed from the thickness direction (Z direction) of the closure portion 30 in a cross section in a plane including the central axis of the container body 11 (i.e., the central axis CL of the container body 110). In this case, the length Lx3 of the imaginary line IL3 may be the distance from the outer surface 30a of the closure portion 30 to the inner edge 20a of the sealing portion 20, and may be 38 mm or less. Furthermore, in this case, the imaginary line IL3 may be a line that does not intersect with any of the inner surface 30b of the closure portion 30, the inner surface 12a of the body portion 12, and the inner surface 13a of the connecting portion 13.

[0145] In this modified example, the liquid Lq can also be efficiently sucked, and the liquid remaining in the liquid container 40E can be reduced.

[0146] (21st Variation) Figures 41 to 44 show a liquid container 40F according to a twenty-first modified example. In Figure 41, the liquid container 40F comprises a container body 11A and a liquid Lq contained in the container body 11A.

[0147] The container body 11A has a cylindrical body 12A, a bottom 15A provided at one end (negative end in the Z direction, first part) 10c of the body 12A, a shoulder 16A provided at the other end (positive end in the Z direction, second part) 10d of the body 12A, and a stopper part 18A connected to the shoulder 16A via a thin-walled part 17A.

[0148] Of these, the body portion 12A has a substantially cylindrical shape, and its horizontal cross section (a plane parallel to the XY plane) is substantially circular. The horizontal cross section of the body portion 12A is also substantially uniform along the vertical direction (Z direction). The horizontal cross section of the body portion 12A is not limited to a circle, but may be a polygon such as a square or hexagon, or an ellipse.

[0149] The bottom portion 15A has a generally circular shape in bottom view, but is not limited thereto, and the closing portion 30 may have a polygonal shape such as a square or hexagonal shape, or a circular shape in bottom view.

[0150] The shoulder portion 16A has a substantially circular horizontal cross section (a plane parallel to the XY plane) that gradually changes in shape from the body portion 12A of the body portion 12A toward the plug portion 18A. In the illustrated example, the shoulder portion 16A has a shape in which the diameter gradually decreases from the body portion 12A toward the plug portion 18A. As described above, the plug portion 18A is connected to the shoulder portion 16A via the thin-walled portion 17A.

[0151] The thin-walled portion 17A is thinned from the radially outward direction. This thin-walled portion 17A is formed over the entire circumference between the shoulder portion 16A and the plug portion 18A. This allows the thin-walled portion 17A to be easily broken. The thin-walled portion 17A includes a breakable portion 17a that acts as a break trigger. The breakable portion 17a is the thinnest part of the thin-walled portion 17A.

[0152] As described above, stopper portion 18A is connected to shoulder portion 16A via thin-walled portion 17A. Stopper portion 18A includes cylindrical portion 18a connected to thin-walled portion 17A, and plate-shaped operating portion 18b provided to surround cylindrical portion 18a in a front view (when viewed from the Y direction).

[0153] 42, the width W4 of the inner surface 16b of the shoulder portion 16A of the container body 11A gradually narrows from the body portion 12A toward the stopper portion 18A. This allows the liquid Lq to be temporarily collected near the intersection P3 between the inner surface 12b of the body portion 12A and the inner surface 16b of the shoulder portion 16A in a cross section taken along a plane including the central axis CLA of the container body 11A. That is, when the remaining amount of liquid Lq becomes low, the liquid Lq can be temporarily collected near the intersection P3, allowing the liquid Lq to be efficiently sucked up. The central axis CLA is a straight line extending in the Z direction and passing through the center of gravity of the planar figure whose outer edge is the bottom portion 15A when viewed from the Z direction.

[0154] In this modification, in a cross section taken along a plane including the central axis CLA, the inner surface 16b of the shoulder 16A is inclined relative to the inner surface 12b of the body 12A so as to fit the shape of the injection needle RB, thereby preventing the liquid from remaining in the container body 11A.

[0155] Furthermore, in a cross section taken along a plane including the central axis CLA, when an imaginary line (fourth imaginary line) IL4 is drawn that passes through an intersection P3 between the inner surface 12b of the body 12A and the inner surface 16b of the shoulder 16A and intersects with a line 17c connecting the planned break portions 17a of the thin-walled portions 17A, an angle α4 formed by the imaginary line IL4 and the inner surface 12b of the body 12A is equal to or greater than 168° and less than 180°. Here, the imaginary line IL4 may be a line that does not intersect with the inner surface 16b of the shoulder 16A and that has the shortest length from the intersection P3 to the line 17c connecting the planned break portions 17a.

[0156] Furthermore, the length Lx4 of the imaginary line IL4 from the intersection P3 to the line 17c connecting the planned rupture portions 17a may be 32.10 mm or less. As a result, the liquid-filled container 40F according to this modification is able to prevent liquid from remaining in the liquid-filled container 40F when an 18-gauge (18G) injection needle is used. The reason why liquid can be prevented from remaining in the liquid-filled container 40F when an 18G injection needle is used is the same as that explained in the thirteenth modification, and therefore will not be explained in detail here.

[0157] Here, in a cross section taken along a plane including the central axis CLA, when an imaginary line IL41 is drawn from the intersection point P3 toward the first portion 10c, passing through a point P31 spaced apart by the length (i.e., Gr / sin(β1)) of the blade surface R2 (see FIG. 29 ) and forming an angle α41 of 180°-β1 with the inner surface 12b of the barrel 12A, the imaginary line IL41 preferably intersects with the line 17c connecting the breakable portions 17a. This prevents the injection needle RB from interfering with the shoulder 16A. In this case, for example, in the case of an injection needle RB with a gauge of 18 (18G, needle outer diameter (Gr): 1.20 mm, blade angle β1: 12°), the length of the blade surface R2 is 5.77 mm. Therefore, the point P31 is 5.77 mm away from the intersection point P3 toward the first portion 10c.

[0158] Furthermore, in a cross section taken along a plane including the central axis CLA, when an imaginary line IL42 is drawn from the intersection point P3 toward the first portion 10c, passing through point P32 spaced apart by the length (i.e., Gs / sin(β2)) of the blade surface S2 (see FIG. 30) and forming an angle α42 of 180°-β2 with the inner surface 12b of the barrel 12A, the imaginary line IL42 preferably intersects with the line 17c connecting the breakable portions 17a. This prevents the injection needle SB from interfering with the shoulder 16A. In this case, for example, in the case of an injection needle SB with a gauge of 18 (18G, needle outer diameter (Gr): 1.20 mm, blade angle β2: 18°), the length of the blade surface S2 is 3.88 mm. Therefore, point P32 is located 3.88 mm away from the intersection point P3 toward the first portion 10c. In this way, when an imaginary straight line IL42 can be drawn in a cross section in a plane including the central axis CLA so that the injection needle SB does not interfere with the shoulder portion 16A, it is possible to prevent the injection needles RB and SB from interfering with the shoulder portion 16A regardless of whether the injection needle RB or the injection needle SB is used.

[0159] 43 , when an imaginary line (fifth imaginary line) IL5 is drawn in a cross section taken along a plane including the central axis CLA, the imaginary line IL5 intersects with the line 17c connecting the rupture portions 17a and the inner surface 15a of the bottom portion 15A. The length Lx5 of the imaginary line IL5 from the line 17c connecting the rupture portions 17a to the inner surface 15a of the bottom portion 15A may be 38 mm or less. Here, the imaginary line IL5 does not intersect with either the inner surface 12b of the body portion 12A or the inner surface 16b of the shoulder portion 16A. Since the length Lx5 of the imaginary line IL5 from the line 17c connecting the rupture portions 17a to the inner surface 15a of the bottom portion 15A is 38 mm or less, the liquid Lq can be collected at a position reachable by a syringe needle when the remaining amount of the liquid Lq becomes low. In other words, even if the remaining amount of liquid Lq becomes low and some of the liquid Lq remains at the corner 19 at the boundary between the inner surface 12b of the body 12 and the inner surface 15a of the bottom 15A, an injection needle with a gauge of 18 (18G, needle outer diameter: 1.20 mm) can be inserted up to the vicinity of the corner 19.

[0160] When using liquid container 40F according to this modification, for example, operating portion 18b is pinched and stopper portion 18A is twisted relative to shoulder portion 16A, causing thin-walled portion 17A to break, and opening 17b is formed on straight line 17c connecting portions to be broken 17a, as shown in FIG.

[0161] As described above, according to this modification, in a cross section taken along a plane including the central axis CLA of the container body 11A, the angle α4 formed by the imaginary line IL4 and the inner surface 12b of the barrel portion 12A is 168° or more and less than 180°. Furthermore, the length Lx4 of the imaginary line IL4 from the intersection P3 to the line 17c connecting the intended rupture portions 17a is 32.10 mm or less. This makes it possible to prevent liquid from remaining in the liquid-filled container 40F when using an 18-gauge (18G) injection needle.

[0162] Furthermore, according to this modification, in a cross section taken along a plane including the central axis CLA of the container body 11A, the imaginary line IL42 intersects with the line 17c connecting the breakable portions 17a. This prevents the injection needle SB from interfering with the shoulder portion 16A. In this case, whether the injection needle RB or the injection needle SB is used, the injection needles RB and SB can be prevented from interfering with the shoulder portion 16A.

[0163] Furthermore, according to this modification, the length Lx5 of the imaginary line IL5 from the line 17c connecting the rupture portions 17a to the inner surface 15a of the bottom portion 15A is 38 mm or less. As a result, even if the remaining amount of liquid Lq becomes low and some of the liquid Lq remains in a corner 19 at the boundary between the inner surface 12b of the body portion 12 and the inner surface 15a of the bottom portion 15A, an injection needle with a gauge of 18 (18G, needle outer diameter: 1.20 mm) can be inserted up to the vicinity of the corner 19. Therefore, even if the remaining amount of liquid Lq becomes low, the liquid Lq can be efficiently aspirated. As a result, the amount of liquid remaining in the liquid-filled container 40F can be reduced.

[0164] In the above-mentioned modified examples, an example in which an 18G injection needle is used has been described, but this is not limiting. For example, the angles and lengths of the imaginary lines IL1 to IL5 may be set based on the dimensions of each example shown in Tables 1 and 2 and the values ​​of the above formulas (1) to (3).

[0165] [Example] Next, a specific example of this embodiment will be described.

[0166] Example 1 One end of the container body (made of polyethylene) was made into an opening and the other end was made into a closed portion, and the liquid storage container (Example) shown in Figures 1 to 4 was produced. At this time, the depth D of the recess at the center point CP was 0.4 mm, and the width W1 was 5.0 mm.

[0167] In this case, a protective cover exhibiting easy-peel properties was attached to the closing portion to cover the recessed portion, and then a leak portion that communicated the inside and outside of the recessed portion was intentionally formed in the protective cover.

[0168] (Freezing test) The resulting liquid storage container was immersed in liquid nitrogen to freeze the liquid storage container. The shape of the frozen protective cover was evaluated. Specifically, the evaluation was performed as follows. The results are shown in Table 3. ○: Deformed so as to protrude from the recess ×: Deformed in a concave manner toward the insertion surface

[0169] Example 2 A liquid storage container was produced in the same manner as in Example 1, except that the depth D of the recess at the center point CP was 0.5 mm. Then, a freezing test was carried out in the same manner as in Example 1. Example 3 11 was produced, the depth d of the stepped portion was 0.8 mm, the width W1 was 10 mm, and the depth D of the recess at the center point CP was 2.0 mm. A liquid storage container was produced in the same manner as in Example 1. A freezing test was then carried out in the same manner as in Example 1. Example 4 11 was produced, the depth d of the stepped portion was 0.5 mm, the width W1 was 6.8 mm, and the depth D of the recess at the center point CP was 0.88 mm, except that a liquid storage container was produced in the same manner as in Example 1. Then, a freezing test was carried out in the same manner as in Example 1. Example 5 11 was produced, the depth d of the stepped portion was 1.0 mm, the width W1 was 6.8 mm, and the depth D of the recess at the center point CP was 1.38 mm. A liquid storage container was produced in the same manner as in Example 1. A freezing test was then carried out in the same manner as in Example 1. (Comparative Example 1) A liquid storage container was produced in the same manner as in Example 1, except that the depth D of the recess at the center point CP was 0.6 mm. Then, a freezing test was carried out in the same manner as in Example 1. (Comparative Example 2) A liquid storage container was produced in the same manner as in Example 1, except that the depth D of the recess at the center point CP was 1.0 mm. Then, a freezing test was carried out in the same manner as in Example 1. (Comparative Example 3) A liquid storage container was produced in the same manner as in Example 1, except that the depth D of the recess at the center point CP was 2.0 mm. Then, a freezing test was carried out in the same manner as in Example 1. Comparative Example 4 11 was produced, the depth d of the stepped portion was 1.4 mm, the width W1 was 6.8 mm, and the depth D of the recess at the center point CP was 1.78 mm. A liquid storage container was produced in the same manner as in Example 1. A freezing test was then carried out in the same manner as in Example 1.

[0170] The results are shown in Table 3.

[0171] [Table 3]

[0172] As a result, in the liquid storage containers of Comparative Examples 1 to 3, in which the ratio of depth D to width W1 (D / W1) was 0.12 or greater, the protective cover was deformed so as to be recessed toward the insertion surface. In other words, even when a leak portion that connects the inside and outside of the recess is intentionally formed in the protective cover, the protective cover is deformed so as to be recessed toward the insertion surface, just as in the case where the protective cover maintains the hygiene of the insertion surface of the recess. For this reason, it was not possible to visually determine the hygiene of the liquid storage container.

[0173] On the other hand, in the liquid storage containers of Examples 1 and 2, in which the ratio of depth D to width W1 (D / W1) was 0.1 or less, the protective cover was deformed so as to protrude from the recess.

[0174] Furthermore, in the liquid storage container of Comparative Example 4, in which the depth d of the step portion was 1.4 mm, which was larger than 1.2 mm, the protective cover was deformed so as to be recessed toward the insertion surface. In other words, even when a leak portion that connects the inside and outside of the recess was intentionally formed in the protective cover, the protective cover was deformed so as to be recessed toward the insertion surface, just as in the case in which the protective cover maintains the hygiene of the insertion surface of the recess. For this reason, it was not possible to visually determine the hygiene of the liquid storage container.

[0175] On the other hand, in the liquid storage containers of Examples 3 to 5, in which the depth d of the step portion was 1.2 mm or less, the protective cover was deformed so as to protrude from the recessed portion.

[0176] Thus, in the liquid storage containers according to Examples 1 to 5, the protective cover having the leak portion that connects the inside and outside of the recess could be deformed to protrude from the recess, compared to the liquid storage containers according to Comparative Examples 1 to 4. Therefore, it was found that the hygiene of the liquid storage container can be visually determined when removing the liquid stored in the liquid storage container.

[0177] The components disclosed in the above-described embodiment and each modification may be combined as needed, or some components may be omitted from all the components shown in the above-described embodiment and each modification. [Explanation of symbols]

[0178] 10 Liquid storage container 10a First Section 10b Second Part 11 Container body 12 Torso 13 Joint 20 Sealed part 20a Inner edge 30 Closing part 30a Exterior 30b Inner surface 31 Recess 31a Opening edge 32 Side 33 Insertion surface 34 Aperture 38 Landmark 40 Liquid containers 45 Syringe needle 70 Protective Cover 74 Tsuba 110 Container body 120a opening 120 Torso 121 Inside 125 First Body 125a inner surface 126 Second body 126a Inner surface 130 bags 140 Connecting member

Claims

1. A liquid storage container, a container body having a hollow body portion with an opening formed in a first portion thereof, and a closure portion provided in a second portion of the body portion and having a recess formed therein that is recessed toward the body portion; a protective cover that covers the recess of the closing portion, The width W of the recess is 1 mm or more and 10 mm or less, The depth D of the recess is 0.1 mm or more and 2.0 mm or less, the protective cover is deformable so as to be recessed toward the insertion surface of the recess when the pressure inside the recess is reduced by immersing it in liquid nitrogen, a step portion is formed on a side surface of the recess, The depth d of the step portion is shallower than the depth of the other portion of the recessed portion, The depth d of the step portion is 1.2 mm or less, A liquid storage container, wherein the depth d of the step portion with respect to the width W of the recess is greater than 0 and is not more than 0.

15.

2. The liquid container according to claim 1 , wherein the closure portion is formed integrally with the body portion.

3. 3. The liquid storage container according to claim 1, wherein the depth of the recess is gradually deepened as the opening edge defining the recess approaches the center of gravity of a planar figure constituting the outer edge when viewed from the depth direction of the recess, or includes a portion where the depth is gradually deepened as the opening edge approaches the center of gravity.

4. 4. A liquid storage container according to claim 1, wherein the center of gravity of a planar figure in which the opening edge that defines the recess forms an outer edge when viewed from the depth direction of the recess is located at a position that does not overlap with the center of gravity of a planar figure in which the outline of the closing portion forms the outer edge when viewed from the depth direction of the recess.

5. 5. A liquid storage container according to claim 1, wherein the protective cover is provided with a flange portion that extends to a position that does not overlap with the closing portion when viewed from the depth direction of the recess, and at least a portion of the flange portion is located on a straight line connecting the center of gravity of a planar figure whose outer edge is formed by the opening edge that defines the recess when viewed from the depth direction of the recess, and the center of gravity of a planar figure whose outer edge is formed by the contour of the closing portion when viewed from the depth direction of the recess.

6. The liquid container according to claim 1 , wherein the recess is provided with a mark that indicates the position of an area where the thickness of the closing portion is equal to or less than a predetermined thickness.

7. The liquid container according to claim 1 , wherein the width of the inner surface of the body portion gradually narrows toward the closing portion.

8. the body portion includes a first body portion located on the first portion side and a second body portion located on the second portion side of the first body portion, The width of the inner surface of the second body portion gradually narrows from the first body portion toward the closed portion, In a cross section taken along a plane including the central axis of the container body, when a first imaginary line is drawn that passes through an intersection between the inner surface of the first body and the inner surface of the second body and intersects with the inner surface of the closure, but does not intersect with the inner surface of the second body, and has the shortest length from the intersection to the inner surface of the closure, the angle formed by the first imaginary line and the inner surface of the first body is 168° or more and less than 180°, In the cross section, the first virtual line intersects with the bottom surface of the recess, The liquid container according to claim 1 , wherein the length of the first imaginary line from the intersection point to the bottom surface of the recess is 32.10 mm or less.

9. 9. A liquid storage container according to claim 8, wherein when a second imaginary line is drawn in the cross section, the second imaginary line passes through a point 3.88 mm away from the intersection point toward the first portion and forms an angle of 162° with the inner surface of the first body portion, the second imaginary line intersects with the opening edge of the recess.

10. a bag attached to the body of the container body and closing the opening; The liquid container according to claim 1 , further comprising a communication member attached to the bag to provide communication between the inside and outside of the bag.

11. A liquid storage container according to any one of claims 1 to 9; a liquid contained in the liquid container, A liquid-filled container with the opening sealed.

12. The container body with the opening sealed has a cylindrical portion, a sealing portion formed in the first portion, a connecting portion formed continuously between the cylindrical portion and the sealing portion, and the closing portion provided in the second portion, The width of the connecting portion gradually increases from the cylindrical portion toward the sealed portion, 12. A liquid-filled container as described in claim 11, wherein when a third imaginary line is drawn in a cross section in a plane including the central axis of the container body, the third imaginary line intersecting the bottom surface of the recess and the inner edge of the sealing portion, respectively, but not intersecting either the inner surface of the tubular portion or the inner surface of the connecting portion, the length of the third imaginary line from the bottom surface of the recess to the inner edge of the sealing portion is 38 mm or less.

13. The liquid storage container according to claim 10; a liquid contained in the bag; A liquid-filled container in which the communication member is sealed.

14. providing a liquid-filled container according to any one of claims 11 to 13; forming an opening in the container body that communicates with the interior; and removing the liquid from the container body through the opening.

15. 15. The method for withdrawing a predetermined amount of liquid according to claim 14, wherein the opening is formed by a syringe needle, and the liquid in the container body is withdrawn through the opening by the syringe needle.

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