Translucent or transparent topical skin preparation

Abstract

To provide a topical skin preparation with improved stability in which a solid or semisolid oil solution is blended in a transparent or translucent soluble system.SOLUTION: A translucent or transparent topical skin preparation contains (A) a solid or semisolid oil solution, (B) an oil solution of hydrocarbons that is liquid at normal temperature, (C) polyoxyethylenated (1-40 E.O.) and polyoxypropylenated (1-30 P.O.) alkyl (C16-C24), (D) a C18-22 higher alcohol, (E) a polyhydric alcohol, and (F) water.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a translucent or transparent external preparation for skin, and in particular to an external preparation for skin with improved stability, which is obtained by blending a solid or semi-solid oil agent into a transparent or translucent solubilizing system. [Background technology]

[0002] Transparent or semi-solid topical skin preparations are formulated by dissolving various moisturizers in water to moisturize the stratum corneum. However, preventing moisture evaporation is essential to improving skin texture. However, moisture applied to the stratum corneum evaporates over time, making it difficult to expect texture improvement. Therefore, formulations such as diluted water-in-oil (O / W) emulsions have been used, but these are thermodynamically unstable and have drawbacks in terms of usability, such as stickiness and a lack of refreshing feel.

[0003] To solve this problem, it is desirable to use an oil with high occlusive properties, specifically a solid or semi-solid oil. For example, Patent Document 1 discloses an oil-in-water microemulsion containing a polyglycerol fatty acid monoester having a degree of polymerization of 3 to 7 and 10 to 22 carbon atoms, a diester of a fatty acid diglycerol and a saturated dibasic acid, squalane, beeswax (solid wax), and jojoba oil, with the aim of moisturizing the stratum corneum and improving its barrier function. Patent Document 2 also discloses a composition containing a branched fatty acid phytosteryl, a fatty acid triglyceride having 10 to 22 carbon atoms, squalane, beeswax (solid wax), and jojoba oil.

[0004] Furthermore, Patent Document 3 discloses a method for producing a thermodynamically unstable water-in-oil (O / W) emulsion, which is a cloudy oil-in-water (O / W) emulsion containing an oil agent that is liquid at room temperature, a nonionic surfactant that is a hydrogenated phospholipid (HLB: 9 to 16), a divalent glycol, and water. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2008-056586 [Patent Document 2] Japanese Patent Application Laid-Open No. 2009-234920 [Patent Document 3] Japanese Patent Application Laid-Open No. 2007-254405 Summary of the Invention [Problem to be solved by the invention]

[0006] However, the techniques described in Patent Documents 1 and 2 were unable to provide a refreshing feel due to the stickiness of the emulsion, which is a surfactant. Furthermore, because it is an emulsion, coalescence of oil droplets over time is unavoidable, and the oil droplets are not sufficiently stable over time.

[0007] Furthermore, Patent Document 3 discloses a method for producing a milky white oil-in-water (O / W) type lotion and emulsion in one product that is stable even at low viscosity in order to provide a refreshing feeling when used. However, because the product requires the incorporation of an oil that is liquid at room temperature, the skin-improving effect of Patent Documents 1 and 2 is minimal, and improvements in this area have been desired.

[0008] Therefore, an object of the present invention is to solve the above-mentioned problems of the prior art and to provide an external preparation for skin with improved stability, which is a transparent or translucent solubilizing system containing a solid or semi-solid oil agent. [Means for solving the problem]

[0009] As a result of intensive research to solve the above problems, the inventors have found that the above object can be achieved by combining a solid or semi-solid oil agent with a specific surfactant, and have thus completed the present invention.

[0010] That is, the translucent or transparent external preparation for skin of the present invention is (A) a solid or semi-solid oil solution; (B) A hydrocarbon oil that is liquid at room temperature; (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24); (D) a higher alcohol having 18 to 22 carbon atoms; (E) a polyhydric alcohol; and (F) water, wherein (1-40 EO) indicates that the number of moles of oxyethylene added is 1 to 40, (1-30 PO) indicates that the number of moles of oxypropylene added is 1 to 30, and (C16-C24) indicates that the alkyl group has 16 to 24 carbon atoms.

[0011] Furthermore, the translucent or transparent topical skin preparation of the present invention preferably contains (G) polyoxyethylene hydrogenated castor oil, and the (G) polyoxyethylene hydrogenated castor oil is preferably one or more selected from the group consisting of PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-80 hydrogenated castor oil, and PEG-100 hydrogenated castor oil.

[0012] Furthermore, in the translucent or transparent topical skin preparation of the present invention, the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) is preferably one or more selected from the group consisting of PPG-6 decyltetradeceth-30, PPG-6 decyltetradeceth-12, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-4 ceteth-1, PPG-8 ceteth-1, PPG-4 ceteth-10, PPG-4 ceteth-20, PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34. [Effects of the Invention]

[0013] According to the present invention, it is possible to provide an external skin preparation with improved stability, which comprises a transparent or translucent solubilizing system and a solid or semi-solid oil agent. DETAILED DESCRIPTION OF THE INVENTION

[0014] The translucent or transparent external skin preparation of the present invention will be specifically described below. The translucent or transparent topical skin preparation of the present invention is characterized by comprising (A) a solid or semi-solid oil, (B) a hydrocarbon oil that is liquid at room temperature, (C) a polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24), (D) a higher alcohol having 18 to 22 carbon atoms, (E) a polyhydric alcohol, and (F) water. The solubilized topical skin preparation has a transparent or translucent appearance, has a skin texture improving effect, and is non-sticky and refreshing to use. Furthermore, by incorporating an oil that is solid or semi-solid at room temperature and has a high occlusive effect in a thermodynamically stable solubilization range, the topical skin preparation has an improved skin improving effect and a non-sticky and refreshing feel to use. The term "translucent or transparent" in the present invention refers not only to visual observation, but also to the determination of lightness (L * a * b * Lightness refers to a state in which the L value (in a color system) is 99.0 or higher, more preferably 99.4 or higher, and translucency refers to a state in which the L value is between 1 and 99. Lightness is one of the attributes of color, and the degree of lightness or darkness of the color is expressed on a scale of 0.0 to 100.0, with the higher the L value, the more transparent the color. Measurement can be performed using a spectrophotometer or the like, but is not particularly limited as long as it is a method that can measure other ordinary lightness. For example, using a spectrophotometer, the transparency can be measured by placing 5 mL of purified water in a glass cell and transmitting light, with the transparency being 100, and by completely blocking light and no transmitted light being 0.

[0015] In the present invention, the solid or semi-solid oil (A) refers to an oil having a melting point at room temperature (about 20 to 25°C) or higher, and is not particularly limited as long as it can be used in ordinary skin external preparations and can obtain the effects of the present invention. Examples of such solid or semi-solid oil (A) include highly occlusive ozokerite, ceresin, microcrystalline wax, petrolatum, candelilla wax hydrocarbon, beeswax, mango butter, coconut oil, palm oil, palm kernel oil, cacao butter, shea butter, hydrogenated coconut oil, beef tallow, milk fat, horse tallow, spermaceti, lanolin, reduced lanolin, adsorbed and refined lanolin, acetated lanolin, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohol, lecithin (paste at 30°C, room temperature), phosphatidylcholine, ... Sphingophospholipids such as sphingomyelin, lysolecithin, phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, cholesterol, dihydrocholesterol, phytosterol, cholic acid, sterols such as sapogenins, saponins, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesterol) Phytosteryl / Behenyl / Octyldodecyl), N-Lauroyl-L-Glutamate Di(Phytosteryl / Behenyl / 2-Octyldodecyl), Cholesteryl Hydroxystearate, Cholesteryl Macadamia Seed Oil Fatty Acid, Phytosteryl Macadamia Seed Oil Fatty Acid, Cholesteryl Soft Lanolinate, Cholesteryl Hard Lanolinate, Cholesteryl Long-Chain Branched Fatty Acids, Cholesteryl Nonanoate, Cholesteryl Soft Lanolinate, Cholesteryl Hard Lanolinate, Cholesteryl Long-Chain Branched Fatty Acids, Lanolin Octyldodecyl lanolinate, cetyl palmitate, hydrogenated castor oil isostearate, isopropyl lanolinate, cetyl lactate, hydrogenated castor oil isostearate paste, glyceryl trihydrogenated rosinate, glyceryl behenate / eicosandioate, dipentaerythrityl hexahydroxystearate / hexastearic acid / hexarosinate, glycol distearate (ethylene glycol distearate), phytosteryl / isostearyl / cetyl / stearyl / behenyl dimer dilinoleate,Examples of the dimer acid or dimer diol derivatives include dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl (C16-18) hydroxydimer dilinoleyl ether, cetanol, myristyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, chimyl alcohol, batyl alcohol, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, 12-hydroxystearic acid, coconut oil fatty acid monoethanolamide (cocamide MEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palutamide MEA), and the like.

[0016] Furthermore, in the present invention, the hydrocarbon oil (B) that is liquid at room temperature is not particularly limited as long as it can be used in ordinary skin topical preparations and can achieve the effects of the present invention. Examples of such hydrocarbon oil (B) that is liquid at room temperature include liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, and squalene. In the present invention, "room temperature" refers to the temperature in a typical room (room temperature), and indicates, for example, a temperature range of 20 to 25°C.

[0017] Furthermore, in the present invention, if the effects of the present invention can be obtained, a liquid oil other than the (B) hydrocarbon oil that is liquid at room temperature can be blended together. Examples of such (B) oils other than the hydrocarbon oil that is liquid at room temperature include vegetable oils such as safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, hydrogenated castor oil, jojoba oil, and hydrogenated jojoba oil; egg yolk oil, mink oil; Animal fats and oils such as citrus oil, orange roughy oil, liquid lanolin, acetated liquid lanolin, N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), N-lauroylsarcosine isopropyl and other acyl sarcosine alkyl esters, phytosteryl isostearate, octyldodecyl myristate, 2-hexyldecyl myristate, octyldodecyl isostearate, cetyl 2-ethylhexanoate, ethyl Hexyldecyl hexanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isostearyl neopentanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl erucate, ethyl oleate, avocado oil fatty acid ethyl ester, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, methylheptyl laurate monoalcohol carboxylic acid esters such as methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; diisostearyl malate, glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, and glyceryl diisostearate;Caprylic / Capric Triglyceride, Caprylic / Capric / Myristic / Stearic Triglyceride, Trimethylolpropane Triethylhexanoate, Trimethylolpropane Triisostearate, Neopentyl Glycol Diethylhexanoate, Neopentyl Glycol Dicaprate, Propylene Glycol Dioleate, Pentaerythrityl Tetraethylhexanoate, Ditrimethylolpropane Isostearate / Sebacic Acid Oligoester, Diglyceryl Diisostearate, Polyglyceryl-2 Tetraisostearate, Polyglyceryl-10 Nonisostearate, Methylpentanediol Dineopentanoate, Diisostearyl Dimer Dilinoleate, Diglyceryl Triisostearate, Dimethicone Examples of such fatty acids include higher alcohols such as di(isostearyl / phytosteryl) imidlinoleate, dimer dilinoleyl diisostearate, oleyl alcohol, jojoba alcohol, oleyl glyceryl, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; isostearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, isohexadecanoic acid; and fatty acid alkanolamides such as coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid diethanolamide (lauramide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA).

[0018] In the present invention, the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) is not particularly limited as long as it can be used in ordinary external skin preparations and can achieve the effects of the present invention. However, it is preferred that the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) is one or more selected from the group consisting of PPG-6 decyltetradeceth-30, PPG-6 decyltetradeceth-12, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-4 ceteth-1, PPG-8 ceteth-1, PPG-4 ceteth-10, PPG-4 ceteth-20, PPG-5 ceteth-20, PPG-8 ceteth-20, and PPG-23 steareth-34. Specific examples include NIKKOL SG-DTD630 (trade name), NIKKOL PEN-4612 (trade name), NIKKOL SG-DTD620 (trade name), NIKKOL PBC-31 (trade name), NIKKOL PBC-33 (trade name), NIKKOL SG-C420 (trade name), and NIKKOL PBC-44 (trade name), all manufactured by Nikko Chemicals Co., Ltd.

[0019] Furthermore, in the present invention, the (D) higher alcohol having 18 to 22 carbon atoms can improve the solubilization of the (A) solid or semi-solid oil agent and the (B) hydrocarbon oil agent that is liquid at room temperature. The (D) higher alcohol having 18 to 22 carbon atoms is not particularly limited as long as it can be used in ordinary topical skin preparations and can achieve the effects of the present invention, but examples thereof include stearyl alcohol, cetostearyl alcohol, oleyl alcohol, behenyl alcohol, isostearyl alcohol, hexyldecanol, octyldodecanol, decyltetradecanol, arachyl alcohol, arachidyl alcohol, and behenyl alcohol. These higher alcohols may be used alone or in combination.

[0020] Furthermore, in the present invention, the (E) polyhydric alcohol improves the solubility of surfactants, and dihydric polyhydric alcohols in particular can improve the moisturizing feeling of the stratum corneum. The (E) polyhydric alcohol is not particularly limited as long as it can be used in ordinary topical skin preparations and can achieve the effects of the present invention, but examples thereof include glycerin, 1,3-butylene glycol, propylene glycol, isopentyldiol, diglycerin, sorbitol, hexylene glycol, pentylene glycol, and polyethylene glycol. These (E) polyhydric alcohols may be used alone or in combination.

[0021] In the present invention, the water (F) is essential for the skin-improving effect by hydrating and retaining the skin. The water (F) is not particularly limited as long as it can be used in ordinary skin preparations for external use and can provide the effects of the present invention, but purified water, etc., can be used.

[0022] Furthermore, the translucent or transparent topical skin preparation of the present invention preferably contains (G) polyoxyethylene hydrogenated castor oil, and the (G) polyoxyethylene hydrogenated castor oil is preferably one or more selected from the group consisting of PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-80 hydrogenated castor oil, and PEG-100 hydrogenated castor oil. The (G) polyoxyethylene hydrogenated castor oil is not particularly limited as long as it can be used in ordinary topical skin preparations and can obtain the effects of the present invention. Examples include NIKKOL HCO-5 (trade name), NIKKOL HCO-10 (trade name), NIKKOL HCO-20 (trade name), NIKKOL HCO-30 (trade name), NIKKOL HCO-40 (trade name), NIKKOL HCO-50 (trade name), NIKKOL HCO-60 (trade name), NIKKOL HCO-80 (trade name), and NIKKOL HCO-100 (trade name), all of which are manufactured by Nikko Chemicals Co., Ltd.

[0023] Furthermore, the translucent or transparent topical skin preparation of the present invention preferably contains a pH adjuster. Such pH adjusters are not particularly limited as long as they can be used in ordinary topical skin preparations and can provide the effects of the present invention, but examples thereof include citric acid, malic acid, tartaric acid, lactic acid, glycolic acid, glutamic acid, aspartic acid, malonic acid, succinic acid, adipic acid, and 2-amino-2-methyl-1-propanol.

[0024] Furthermore, the translucent or transparent topical skin preparation of the present invention preferably contains a stabilizer. Such stabilizers improve the stability of the topical skin preparation by using a sequestering agent, antioxidant, preservative, or the like. The stabilizer is not particularly limited as long as it can be used in ordinary topical skin preparations and can achieve the effects of the present invention. Examples of the stabilizer include sequestering agents such as hydroxyethanediphosphonic acid, edetic acid and its salts, antioxidants such as dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, erythorbic acid, and L-cysteine ​​hydrochloride, and preservatives such as methylparaben, ethylparaben, benzoic acid, benzoates, salicylic acid, salicylates, phenoxyethanol, water-soluble cationic antibacterial agents, ethylhexylglycerin, bisabolol, and poly-ε-lysine.

[0025] Furthermore, the translucent or transparent topical skin preparation of the present invention can contain surfactants other than the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) and (G) polyoxyethylene hydrogenated castor oil, as long as the effects of the present invention can be achieved. Examples of such surfactants include propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin and fatty acid esters, polyoxyethylene glycerin fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene lanolin-lanolin alcohol-beeswax derivatives, polyoxyethylene sterol-hydrogenated sterol, polyethylene glycol fatty acid esters, polyoxyethylene alkylphenyl ethers, polyoxyethylene alkylamine-fatty acid amides, polyoxyethylene alkylphenyl formaldehyde condensates, and polyoxyethylene alkyl ether phosphoric acid-phosphate salts.

[0026] Furthermore, the translucent or transparent external skin preparation of the present invention preferably contains the (A) solid or semi-solid oily agent in an amount of 1 to 5% by mass, the (B) hydrocarbon oily agent in a liquid state at room temperature in an amount of 0.5 to 8% by mass, the (C) polyoxyethylenated (1 to 40 EO) and polyoxypropylenated (1 to 30 PO) alkyl (C16 to C24) in an amount of 1 to 8% by mass, the (D) higher alcohol having 18 to 22 carbon atoms in an amount of 0.5 to 2.0% by mass, the (E) polyhydric alcohol in an amount of 1 to 20% by mass, and the (F) water to be adjusted to 100% by mass. By using such an amount, it is possible to obtain an external skin preparation that has a refreshing feel when used and has a texture-improving effect, and in particular, the moisture evaporation inhibitory effect of the (A) solid or semi-solid oil agent is improved, and the (B) hydrocarbon oil agent that is liquid at room temperature can be used both as a moisture evaporation inhibitor and as a solvent for the (A) solid or semi-solid oil agent.

[0027] Furthermore, it is more preferable that the content of the (A) solid or semi-solid oil solution is 1 to 3 mass %, the content of the (B) hydrocarbon oil solution that is liquid at room temperature is 1 to 5 mass %, the content of the (C) polyoxyethylenated (1 to 40 EO) and polyoxypropylenated (1 to 30 PO) alkyl (C16 to C24) is 1 to 3 mass %, the content of the (D) higher alcohol having 18 to 22 carbon atoms is 0.5 to 1.0 mass %, the content of the (E) polyhydric alcohol is 5 to 12 mass %, and the content is adjusted with the (F) water to 100 mass %. By using these blending amounts, it is possible to obtain an external skin preparation that has a refreshing feel when used and has a texture-improving effect, and in particular, the texture-improving effect of the (A) solid or semi-solid oil agent is further improved, the (B) hydrocarbon oil agent that is liquid at room temperature is used as an emollient and as a solvent for the (A) solid or semi-solid oil agent, and the (D) higher alcohol having 18 to 22 carbon atoms is dissolved in the (C) polyoxyethylenated (1 to 40 EO) and polyoxypropylenated (1 to 30 PO) alkyl (C16 to C24) pallisade layer, thereby increasing the number of micelles and further reducing the stickiness of the (E) polyhydric alcohol.

[0028] Furthermore, the translucent or transparent topical skin preparation of the present invention preferably contains the polyoxyethylene hydrogenated castor oil (G) in an amount of 1 to 5% by mass, more preferably 2.5 to 3.5% by mass, which can further improve the stability of the translucent or transparent topical skin preparation of the present invention.

[0029] In the present invention, topical skin preparations are those that can be used on the human body, etc., and belong to the classification of ordinary cosmetics, and do not exclude applications as quasi-drugs, pharmaceuticals, etc. Furthermore, the topical skin preparations also include applications as basic cosmetics, makeup cosmetics, hair cosmetics, etc.

[0030] Furthermore, in the present invention, other ingredients may be added as appropriate within the range that does not impair the effects of the present invention. Any ingredients other than those described above may be blended within the qualitative and quantitative ranges, and ingredients that are usually blended in topical skin preparations, such as moisturizers, fragrances, various vitamins, ultraviolet absorbers, powders and colorants, medicinal ingredients, inorganic salts, plant extracts, and other useful ingredients, may be blended.

[0031] Examples of extract components include chamomile extract, parsley extract, honeysuckle extract, rice extract, rice bran extract, hop extract, Phellodendron bark extract, Job's tears extract, Swertia japonica extract, Melilot extract, birch extract, licorice extract, peony extract, soapwort extract, loofah extract, chili pepper extract, lemon extract, gentian extract, perilla extract, aloe extract, rosemary extract, sage extract, thyme extract, eucalyptus extract, tea extract, seaweed extract, cucumber extract, clove extract, carrot extract, horse chestnut extract, witch hazel extract, mulberry extract, tangerine peel extract, pecan nut extract, grapefruit extract, Citrus depressa extract, passion fruit extract, loquat extract, grape extract, rose fruit extract, Sophora flavescens extract, and peppermint extract.

[0032] Examples of moisturizing ingredients include xylitol, maltitol, sodium chondroitin sulfate, elastin, glucosamine, hyaluronic acid, cyclodextrin, collagen, and bile salts.

[0033] Examples of medicinal ingredients include vitamins such as vitamin A, vitamin B, vitamin C, vitamin D, and vitamin E and their derivatives, glycyrrhizinic acid and its derivatives, various salts of urea, creatinine, CoQ10, astaxanthin, polyphenols, and ceramides.

[0034] In addition, in the present invention, the translucent or transparent topical skin preparation can be produced by a conventional method for producing topical skin preparations, and a method of producing the preparation by heating an oil phase component and an aqueous phase component can be used.

[0035] In the present invention, an example of a method for producing a translucent or transparent external skin preparation is a method in which the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) are dissolved in the (E) polyhydric alcohol, and an oil phase prepared by dissolving the (A) solid or semi-solid oil solution, the (B) hydrocarbon oil solution that is liquid at room temperature, and the (D) higher alcohol having 18 to 22 carbon atoms is added thereto and mixed.

[0036] Another example of a method for producing a translucent or transparent topical skin preparation is a method in which the (E) polyhydric alcohol is dissolved in the (F) water to form an aqueous phase, the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) is dissolved in the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) and the (A) solid or semi-solid oil solution, the (B) hydrocarbon oil solution that is liquid at room temperature, and the (D) higher alcohol having 18 to 22 carbon atoms are dissolved in the aqueous phase to form an oil phase, and the oil phase is mixed with the aqueous phase to solubilize the oil phase.

[0037] Furthermore, still another example of a method for producing a translucent or transparent external skin preparation is a method in which the (E) polyhydric alcohol is dissolved in the (F) water to form an aqueous phase, the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) is dissolved in the (C) polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) is dissolved in the aqueous phase, and the (A) solid or semi-solid oil solution, the (B) hydrocarbon oil solution that is liquid at room temperature, and the (D) higher alcohol having 18 to 22 carbon atoms are dissolved in the aqueous phase to form an oil phase, the oil phase is mixed with the aqueous phase, and after solubilization, the pH adjuster and / or the stabilizer is mixed.

[0038] The present invention will be described in more detail below using examples, but the present invention is not limited to these examples. Furthermore, the numerical values ​​in the formulations below represent mass %. [Example]

[0039] (Examples 1 to 3, Comparative Examples 1 to 5) The topical skin preparations of Examples 1 to 3 and Comparative Examples 1 to 5 were prepared according to the manufacturing methods described below and using the formulations shown in Tables 1 and 2 below. The obtained topical skin preparations were evaluated using the evaluation methods described below, and the results are shown in Tables 1 and 2 below.

[0040] (Manufacturing method) Polyhydric alcohols (pentylene glycol and BG) were dissolved in purified water to form the aqueous phase. Nonionic surfactants (PPG-4 ceteth-20 and PEG-10 hydrogenated castor oil) were dissolved, and the solid and semi-solid oils, liquid oils, and higher alcohols listed in Tables 1 and 2 below were dissolved to form the oil phase. The oil phase was mixed with the aqueous phase to solubilize it, and then phenoxyethanol was mixed and dissolved.

[0041] (Evaluation method) (appearance, stability) The stability of the obtained external skin preparations was visually observed on the day of preparation and one and three months after preparation, and evaluated according to the following evaluation criteria. ◎: Translucent ~ Transparent 〇: Translucent △: Cloudy ×: Cloudy, separation

[0042] (Usability) A sensory test was conducted on the usability of "stickiness" and "refreshing" by a panel (one male and one female sensory testers aged 27 to 75 years). The evaluation was done on a 5-point scale, with a positive "stickiness" being marked (+) and a negative "-" and +2 and -2 added to the center (±). Similarly, for "refreshing," a positive "refreshing" was marked (+) and a negative "not refreshing" was marked (-).

[0043] [Table 1]

[0044] [Table 2]

[0045] The results in Tables 1 and 2 show that the topical skin preparations of Examples 1 to 3 were stable and easy to use, whereas the topical skin preparations of Comparative Examples 1 to 5 were unstable and felt sticky to the touch.

[0046] (Examples 4 to 7, Comparative Example 6) The topical skin preparations of Examples 4 to 7 and Comparative Example 6 were prepared according to the above-mentioned manufacturing method and with the formulations shown in Table 3 below. The stability of the obtained topical skin preparations was evaluated using the above-mentioned evaluation method, and the results are also shown in Table 3 below.

[0047] [Table 3]

[0048] The results in Table 3 show that the external skin preparations of Examples 4 to 7 had good stability, whereas the external skin preparation of Comparative Example 6 had poor stability.

Claims

1. (A) 1 to 5 mass% of a solid or semi-solid oil solution; (B) 0.5 to 8 mass% of a hydrocarbon oil agent that is liquid at room temperature; (C) 1 to 8 mass% of polyoxyethylenated (1 to 40 E.O.) and polyoxypropylenated (1 to 30 P.O.) alkyl (C16 to C24); (D) 0.5 to 2.0 mass% of a higher alcohol having 18 to 22 carbon atoms; (E) 1 to 20% by mass of a polyhydric alcohol; (F) water, and a translucent to transparent solubilized skin external preparation characterized by comprising:

2. (G) polyoxyethylene hydrogenated castor oil, 2. The translucent or transparent solubilized external skin preparation according to claim 1, wherein the polyoxyethylene hydrogenated castor oil (G) is one or more selected from the group consisting of PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-80 hydrogenated castor oil, and PEG-100 hydrogenated castor oil.

3. 3. The translucent to transparent solubilized topical skin preparation according to claim 1 or 2, wherein the (C) polyoxyethylenated (1 to 40 E.O.) and polyoxypropylenated (1 to 30 P.O.) alkyl (C16 to C24) is one or more selected from the group consisting of PPG-6 decyltetradeceth-30, PPG-6 decyltetradeceth-12, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-4 ceteth-1, PPG-8 ceteth-1, PPG-4 ceteth-10, PPG-4 ceteth-20, PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34.

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